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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
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    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </protein>
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    <organism evidence="1 2">
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="AFH42015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="43" mass="4899" checksum="1E2C6F4B1484D2C1" modified="2012-06-13" version="1">MQNLSDRIESFVTASNTLALFCRISQIELKGESNLDRLKDPML</sequence>
</entry>
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    <name>H9ZZ74_FERFK</name>
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        <submittedName>
            <fullName evidence="4">Stomatin</fullName>
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    <gene>
        <name evidence="4" type="ordered locus">FFONT_0035</name>
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            <taxon>Archaea</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH42031">
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42031.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="285" mass="31554" checksum="5F2C82B28BAB8BFC" modified="2012-06-13" version="1">MYISANLGEIIGISIAVLFVLIFFLSGIKVFKEWERAPYLVLGRFRGFKGPGIVYIVPLISKVPFVISTRLQTQAFKTEQTLTKDNVPVNVDAVMYFQPVDLEKVVLNVEDYILATTLAAQTTLREVIGGITLDELLAEREKIGTIARNIIDQKTEAWGIKVTSVEIRDVLIPTALQEAMSRQAAAERERRARVTLAQAEYEAAAKMIEAAKLYESSKYGLELRWMNILYELGLQGKGTLMLIPTNLMPAGPGAVSPYGIVGLREVAEMGEKKEEKTGKEGLTAK</sequence>
</entry>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0039</name>
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            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0039"/>
    <dbReference type="EnsemblBacteria" id="AFH42035">
        <property type="protein sequence ID" value="AFH42035"/>
        <property type="gene ID" value="FFONT_0039"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0039"/>
    <dbReference type="eggNOG" id="arCOG05870">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062537_0_0_2"/>
    <dbReference type="OMA" id="DVSNWGA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025504">
        <property type="entry name" value="DUF4392"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14336">
        <property type="entry name" value="DUF4392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4392" evidence="1">
        <location>
            <begin position="11"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="329" mass="35421" checksum="D2FFBD45D2E4A6F9" modified="2012-06-13" version="1">MHQYEELGIKLDQLINSDSNGRGVAKKLYPYAFEKAGEPLVYKAARELVENSDKGSPVLIMTGFRTPPLYVQETDGPLGAASISRAFSICLNAKPIILTEQDERSLRIVRAAVEGAGLKISPLEDLLRGDQDLSASVVGFTHSEEYAEEDAKRLIDEVNPRAVIAVKKAGRNFKGVYHSMSGLNVSKYHAKVEYIVDEARKKGILTIGTGDGGNEVGMGAIEDAVRKHVPYGDVCRCPCRGGIASSSKVDVLITSSISNWGGYALSGMISKILEKPNGIHDPEAEELMFSLVAKEGAVDGIKGKAGKSADGLGVEAHKSVLMLIREMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ79</accession>
    <name>H9ZZ79_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParB-like nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0040"/>
    <dbReference type="EnsemblBacteria" id="AFH42036">
        <property type="protein sequence ID" value="AFH42036"/>
        <property type="gene ID" value="FFONT_0040"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0040"/>
    <dbReference type="eggNOG" id="arCOG01875">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107444_0_0_2"/>
    <dbReference type="OMA" id="IGIYVEK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="1">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="220" mass="25621" checksum="69D9E4AF384FF161" modified="2012-06-13" version="1">MSIRSWRNAELLRIDEIIPAEDIEEPRLKYLLASLREKKVLHRPIIVEHRKMLVIDGHHRLRALEASGAKLVPVILADYRSDVRSVGRWMYIGSWSIDRETVLKRGLEELEHLVKRGGSRKIEAKVRNETMNIKADRLDAYISLKYSELLRRVMNELSKVPFDEGKCRSSEICLSFPELEIDDMYRIPYTSLLPPRSTLHETSLKEIEVPFKLNDLGGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ85</accession>
    <name>H9ZZ85_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0047"/>
    <dbReference type="EnsemblBacteria" id="AFH42042">
        <property type="protein sequence ID" value="AFH42042"/>
        <property type="gene ID" value="FFONT_0047"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0047"/>
    <dbReference type="HOGENOM" id="CLU_2461634_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="88" mass="10047" checksum="61103A8B894D5D78" modified="2012-06-13" version="1">MHSGYRFSQSASLSEDAGGFVLKREGGVEDEMKRLESRLKRAEKLLGSHKLPMNRIKNIIETSVDWRVCSPDTIRRISKELKEAQSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ96</accession>
    <name>H9ZZ96_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0059"/>
    <dbReference type="EnsemblBacteria" id="AFH42053">
        <property type="protein sequence ID" value="AFH42053"/>
        <property type="gene ID" value="FFONT_0059"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0059"/>
    <dbReference type="eggNOG" id="arCOG01442">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1063971_0_0_2"/>
    <dbReference type="OMA" id="IGHHEAM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="261" mass="30828" checksum="9342BF9DA7CA6B64" modified="2012-06-13" version="1">MSFWARKGQMLDEHIKKMIDFYEKCYKRRKYTARLSKRLGIPERELDMAMVSTIIFHDMGKIFYHNPETKEPPESFAGHEILSSLVMHIASKKLELKKNMKPDDFSFYAVPISMHLAVRAHHLAMGDRLSTLAIINRFYGRFLNSTYRSKIPFILRDFLAKVVNGMGLEEWLEMREKVEDEELKGLIETYKEFTERYLAWNIFEMHEPKAAKVSMMAQHILKVLIMSDNYSASQVESDMGEERNIKKKFFVDFDLSCIEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ99</accession>
    <name>H9ZZ99_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CRISPR-associated protein Cas5 family. Subtype I-A/Apern subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0062"/>
    <dbReference type="EnsemblBacteria" id="AFH42056">
        <property type="protein sequence ID" value="AFH42056"/>
        <property type="gene ID" value="FFONT_0062"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0062"/>
    <dbReference type="eggNOG" id="arCOG02670">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1154391_0_0_2"/>
    <dbReference type="OMA" id="ERAAWGI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010153">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5a-typ"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01874">
        <property type="entry name" value="cas_cas5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <sequence length="243" mass="27598" checksum="214582251E6BE9AC" modified="2012-06-13" version="1">MNFGIITATKSRTSFRLPPPTTLIGALSYPLAKLKNFPESSEDYMPKLLSSSLRGVYFRSGLSLLPYSTVTKMWFYKKNERELKSDAFAYQRLYVSGESDLSVIYLFDEDAASRNLGHRWKEEVIAASFSMVRLGDKESLISPTKVSYGVAEEICNKEFVTDYTVPLTQIGLKVESFDGGVVEIVEHYDWRKMSGPTSMGMPTIKVAFAYDGSVFTQKKLRVYSDRDICAYAIEENEIKLIEW</sequence>
</entry>
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                <person name="Bidzhieva S.Kh."/>
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        </source>
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    </evidence>
    <sequence length="40" mass="4839" checksum="8D3BEA46593591F9" modified="2012-06-13" version="1">MNLLDRIESNNEAFVLELFQMNLLDRIERLLAQYQLMQVL</sequence>
</entry>
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                <person name="Ravin N.V."/>
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            <end position="379"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF00437"/>
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    </evidence>
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    </evidence>
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    </evidence>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Ravin N.V."/>
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    <accession>H9ZZI2</accession>
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                <person name="Ravin N.V."/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4"/>
            <end position="106"/>
        </location>
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    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="117" mass="13398" checksum="F4CB0CB5864C80AD" modified="2012-06-13" version="1">MRLIDTSVLIEDVKKGVYEEGAISSITLIEVLRGIAPEKRVMVKELLEKSYELKSLDNEAILKYCELYDALKEKENLIRDADLLIASVAIAKNLELMTKDKDFERQKDLGLKLKLEK</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="AFH42148.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="100" mass="11227" checksum="DF82EB4B6D11DDF2" modified="2012-06-13" version="1">MGTIDISLFVRVPEAGYLTSLSDAISSILREKTHVGGTITGLTEEGCVLFAQPHFSSIQWLDEQQKIGFKIRIICEEPISVYKVIKSIRSKIEREIALEF</sequence>
</entry>
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    <accession>H9ZZJ7</accession>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="96" mass="10694" checksum="F7E62B3FDD6B3172" modified="2012-06-13" version="1">MGILRAVLDVLIPIKGIGIDELSLVLERVRGVEGVNITVKEIDVETESILIVIEGRDIDLKEVERELLNYGGVIHSIDQVISGKKIVEIPEFLYEL</sequence>
</entry>
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    <name>H9ZZK9_FERFK</name>
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        <submittedName>
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        <name evidence="2" type="ordered locus">FFONT_0174</name>
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    <organism evidence="2 3">
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="249"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42166.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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    </evidence>
    <sequence length="358" mass="41774" checksum="F91AA06CF54F1AB5" modified="2012-06-13" version="1">MLFDPRPKVNKKDLYDFEKEFEFLKKNIGEPLLVVSGLRRTGKTSLILSTLNDSDIPYVFFDMRSMPNSRRDLYHLLSEGLTDFLTRISNKEKFYKSLTKMLKLIRGISVDGFEVSLSWGKDRASLVEILRALDESCVEHGIKAVIVFDELQRVTGKLSVELANAIAYSYDHLRNLSFIVSGSEMGVLYRFFDEPNAPLYGRAYLEVKTRRLDKEKSIDFLKRGFEESKIRVNDEELEAAVDKLDGIIGWLTYYGYSRTMQNRDFESIWREAVTMARQELENFLKNRVSAERYRAVLKFLANGEREWKELKKKMEDLEGRVLSERVLYDILITLRKYSIIDDQNNFLDPLAEEAARNL</sequence>
</entry>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42201">
        <property type="protein sequence ID" value="AFH42201"/>
        <property type="gene ID" value="FFONT_0210"/>
    </dbReference>
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        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="F:iron-sulfur cluster binding"/>
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        <property type="entry name" value="Elp3/MiaB/NifB"/>
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        <property type="entry name" value="rSAM"/>
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        <property type="entry name" value="Radical_SAM"/>
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</entry>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <end position="61"/>
        </location>
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        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="171" mass="18581" checksum="92BF11A5494CBC5F" modified="2012-06-13" version="1">MIKMQWVESLVGMILYLFGANFFVLGMSLMSNKPDLKSSGVFCEAAAIFNVVAALYAATALNLGTTATFALTFGVIWVALGIILIKGYGLTPVGDYSLYAAIGMIWFLYAFIALVHNYLFAYATTLYIITFIAIFLMTRGKVSLKALGWLLIVFGIIGVLVPALMLFMGLA</sequence>
</entry>
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                <person name="Mardanov A.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42246">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="AFH42246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="100" mass="11496" checksum="BF28BCDBA7599D06" modified="2012-06-13" version="1">MNAEKEIVENSLDVIYEDKDLVVMLAPHVDKLENIILELFKNNCKGFTIKELHELLKGLASEEKIRKTVYKFKKEKIIVLNDGGKYVLNTNNTFATSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZV5</accession>
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        <recommendedName>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42262">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="55"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="164" mass="18411" checksum="F1031CA0D89FDA4E" modified="2012-06-13" version="1">MGIFKIFDEKKIPYIALDMPYGIKNSCEPKDTDMHKNEAFLEEALKKIKKDLKPPLLVGASMGGYLALLYSASNPVSGLLLIGPVGTDDTYVLSSLNKYNFPVCVIIGEKDTIIDFDSVKKFVESLPNGKLKVYESSGHPAYLYKKDRFIEDVLSTYNAIRKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZY8</accession>
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        <submittedName>
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    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0305</name>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="3" key="1">
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0305"/>
    <dbReference type="EnsemblBacteria" id="AFH42295">
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    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0305"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="153" mass="17814" checksum="548AAE9B4A06F1A9" modified="2012-06-13" version="1">MNIMSNDKKSELKKFLEEKIGQLKKEQEYYEFLLAILESGISSQKQNYQEEKEESVEIKVNKKSIAIISMSSSYIKLRPLFDVEKNEDMLKELKKDIELIAEDAKTSVIEDRNLVKEISIEIKKLTPLSIKGISEALKLFITDYYKNINKISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZZ4</accession>
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        <submittedName>
            <fullName evidence="6">Fe-S oxidoreductase</fullName>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0311"/>
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        <property type="protein sequence ID" value="AFH42301"/>
        <property type="gene ID" value="FFONT_0311"/>
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    <dbReference type="OMA" id="CIFCSVD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040088">
        <property type="entry name" value="MJ0103-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11228:SF35">
        <property type="entry name" value="PTHR11228:SF35"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01110">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="35"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="346" mass="39607" checksum="82FE22D73C9456BA" modified="2012-06-13" version="1">MVILESKLGLTKVGKVLEIRKPFPLIGHISFGIIDRGYNNLQVRITTLCSLSCIFCSVSAGPKSNREREFILRDPEWLYEWIKYACNFKSSFHLIFDGMGDPITHKDLPEFVKAVREMKNVKSITVETRLFPANIKTLEKLKDAGIDRLNVSIDTLNEEKGKLLSGNNFYSVKKVKELIKYAHEELGIAIHLAPVWIPTVNDEDIEEIIQFAIKIGLGEKFPPLGIQKYVSHKYGRKVPGIIALSWKEFEKWMRKLEDRYKIKLLLDPKDYGLEKSERIPNGYKKGEIVKLSLVEKGLLKNEYLAIPPKKDRVFTLISRRESLSIGDIVYAKIIHDKDGILIAIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A000</accession>
    <name>I0A000_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide ABC transporter, ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0317</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0317"/>
    <dbReference type="EnsemblBacteria" id="AFH42307">
        <property type="protein sequence ID" value="AFH42307"/>
        <property type="gene ID" value="FFONT_0317"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0317"/>
    <dbReference type="eggNOG" id="arCOG00184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_2"/>
    <dbReference type="OMA" id="GRYPHMF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="32"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="383" mass="44047" checksum="8D915634393202F8" modified="2012-06-13" version="1">MTEIKELEKFFEDHPENLLIVNNLMVWFPIKRGIGEIFRRKPQRYVKAVDNVSFNIKKEETFCLVGESGCGKTTTGKSLLRLVPITSGVGLFRPSDITIERLKKEGIKVNNGYVNIYGLPPKKVKPIRKDIQMIYQDPFGSLNPRYKIMDILTEPLKIHNIGLSEEEERELVYKTLEKVKLKPPEDFADRHPHQLSGGQRQRIAIAKAMIMGPRLIVADEPVSMLDVSIRAEVLELLMNFKNENKLSYLFITHDLAVARYICDRIAVMYLGKIVEMGKARNIIEQPMHPYTRALVAAIPEPDPSNRLKVRKLFIKGEVQSAANIPSGCRFHPRCMAYDENKPILGDICEKEDPGYYITEDGRLVSCWLYKNLKKAEKFEDFYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A009</accession>
    <name>I0A009_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0326"/>
    <dbReference type="EnsemblBacteria" id="AFH42316">
        <property type="protein sequence ID" value="AFH42316"/>
        <property type="gene ID" value="FFONT_0326"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0326"/>
    <dbReference type="eggNOG" id="arCOG01601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058423_0_0_2"/>
    <dbReference type="OMA" id="PCILEIG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="49"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="288" mass="31802" checksum="F70FE31B031AE458" modified="2012-06-13" version="1">MREHVLPGDAACPGCPIPIGLKTVAAAFNGNAVLVIPACCTSVVVGTYPYSSLKMNIVHTPFASSASVASGLREALKQRGLEDTQVIVWAGDGGTADIGMASLSGAAERNEDIIYIMYDNEAYMNTGIQRSSSTPIKAWTTTTPVYGKSEPKKDVARIMIAHNVPYVATASIAYPQDLYQKLKKAQEIRGFRFIQLHSPCPVGWRFDASKTVEVARLAVETGMWILYEYFDNKLRVSGPSMPVIKEGKIKPIEDYIKIQRRFSNINGEGILEIQRMRDNNIEWIKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I0A014</accession>
    <name>I0A014_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Methionine aminopeptidase</fullName>
            <shortName evidence="3">MAP</shortName>
            <shortName evidence="3">MetAP</shortName>
            <ecNumber evidence="3 4">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">map</name>
        <name evidence="6" type="ordered locus">FFONT_0331</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="3 4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="3 4">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0331"/>
    <dbReference type="EnsemblBacteria" id="AFH42321">
        <property type="protein sequence ID" value="AFH42321"/>
        <property type="gene ID" value="FFONT_0331"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0331"/>
    <dbReference type="eggNOG" id="arCOG01001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_7_0_2"/>
    <dbReference type="OMA" id="NEIAAHY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01975">
        <property type="entry name" value="MetAP_2_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028595">
        <property type="entry name" value="MetAP_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="11"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="306" mass="34482" checksum="55682429459B790A" modified="2012-06-13" version="1">MEEEEIQSYINAGKISIEAKKYARSIAKPGMTFFELAEKIEGKIQELGGKLAFPCNLSFGHVAAHYSPLLDSEDIIPENGILKIDLGVHVNGFIADTAFSIDFSGENENLLMASKEALERAIDIIRPGIKISEISEIIEKTIISYEAKPIRNLTGHELQNYKLHSGLVIPNTKNLLVSGRLKPNIAIAIEPFATNGAGVVIDSNFTAIYSLNLKSPHETKKLEPTLRDFYRYIFDEFKELPFNERYFKNYIDKNTFRKNIATLVSKKLAIGYPMLIESGNGEVAQFEESILILEKEVIPYTKEKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A024</accession>
    <name>I0A024_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0341"/>
    <dbReference type="EnsemblBacteria" id="AFH42331">
        <property type="protein sequence ID" value="AFH42331"/>
        <property type="gene ID" value="FFONT_0341"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0341"/>
    <dbReference type="eggNOG" id="arCOG00033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_0_0_2"/>
    <dbReference type="OMA" id="HYYDIQH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="3">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="286" mass="33248" checksum="9D9D1E81BC1609A3" modified="2012-06-13" version="1">MRNDVISDILKELNINEKIEASIDLIGDIAVIKSPVWIKNYELEIFKKIAEKLASRMPYVKSIWLTETPIYGIERTRKYIHLYGERKTVTIYKEHDCSFYVDIEKSYISPRLSYEHIRIAKLVKDNEIIINMFSGIGGFSIVIAKYSNPKIIYSIDINPFSVELQKKNVELNNLTEKIIVLLGDAREIMTRDLKNTADRVLLPLPNIDSSFYNAALTSLRNPYGFLHIYEFEKYDGKKECAINKAYEKVKEKFLSLGWKSELIFGRIVRTVGPRKAQVVLDVYTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A030</accession>
    <name>I0A030_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0347"/>
    <dbReference type="EnsemblBacteria" id="AFH42337">
        <property type="protein sequence ID" value="AFH42337"/>
        <property type="gene ID" value="FFONT_0347"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0347"/>
    <dbReference type="eggNOG" id="arCOG05401">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130233_0_0_2"/>
    <dbReference type="OMA" id="EAEMITY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="172" mass="18982" checksum="0543D9405F269BE9" modified="2012-06-13" version="1">MTENKSNENEEKKITITIRGIDKDLYEKISNKAKQLNTTVGSLVNEAIGNLLASIDIGIEKTSKIVDTTIKAASEAIKTPLSELKSSITTQDYIIISNIGEITVSKNDLESSEKPLIFVNVKRIVFADNVTEELIKNKVRAIKVSDEVIIPKTISSMTIAQKSQFVKKITSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I0A047</accession>
    <name>I0A047_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sucD</name>
        <name evidence="7" type="ordered locus">FFONT_0364</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0364"/>
    <dbReference type="EnsemblBacteria" id="AFH42354">
        <property type="protein sequence ID" value="AFH42354"/>
        <property type="gene ID" value="FFONT_0364"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0364"/>
    <dbReference type="eggNOG" id="arCOG01339">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_2"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="290" mass="31066" checksum="B9D43EFFAB2C40A8" modified="2012-06-13" version="1">MAILVNKDTKVLVQGITGKEGSFHTKLMLEYGTKIVAGVSPGKEGQEVYGVKVYNSVENAMSENPHIDASIIFVPAAFTADAVYEAIKNKIKNIIVITEGIPVHETMKFVNYANEKGIRIIGPNCPGIIVPNETKIGIMPGSVFTRGPVGIMSRSGTLTYEISYALSREGIGQSTVIGVGGDPIIGLNFIEVMKLFNDDKETKAVVMVGEIGGDIEERVAMRFKKGEFDKPIVAYIAGKTAPPGKRMGHAGAIITMGEGTYEGKIKALENAGIPVAKNPFEIPKLISKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A072</accession>
    <name>I0A072_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division protein CdvB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0389"/>
    <dbReference type="EnsemblBacteria" id="AFH42379">
        <property type="protein sequence ID" value="AFH42379"/>
        <property type="gene ID" value="FFONT_0389"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0389"/>
    <dbReference type="eggNOG" id="arCOG00453">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_876037_0_0_2"/>
    <dbReference type="OMA" id="IVKKWIL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="317" mass="36792" checksum="637E7D10C9F65B72" modified="2012-06-13" version="1">MGLSIDRDEKKAGLLGWLKNIFGSPKNYTWEDMIQDVIVRLKDEGEKFDELEYRTKKRIQELTDRIVENLKKYDSPNIKEDEKRTYHNLAKMYAEEVYELRNFLKAILFTKISFERVIQRLQTVRDYKDFQAALGPVSKMLAGVKNEISAIFPKVGETLDEINRNITDMMISTSNSMGGFNTNQTFMINEDVEKIIQEAWKLADSNVEKMLPEPKKLIQQTTQITNLSTQQSTQREINQQKSIVNKTEKIQLEAQTSSSSYNIEIVENIILNEIKKTGGKLNIQEITTNYGIDKEKIYEALYNLKKKGKIEIKDNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A073</accession>
    <name>I0A073_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell division protein CdvA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0390"/>
    <dbReference type="EnsemblBacteria" id="AFH42380">
        <property type="protein sequence ID" value="AFH42380"/>
        <property type="gene ID" value="FFONT_0390"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0390"/>
    <dbReference type="eggNOG" id="arCOG04054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100857_0_0_2"/>
    <dbReference type="OMA" id="MIAVKMS"/>
    <dbReference type="Proteomes" id="UP000007391">
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    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041461">
        <property type="entry name" value="CdvA_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18822">
        <property type="entry name" value="CdvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CdvA" evidence="2">
        <location>
            <begin position="90"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="250" mass="28377" checksum="42DDA5886708B392" modified="2012-06-13" version="1">MKMVIYTVDMLDKYVGQKVKDPYQRVVGSLASIYSNVDGNVNAVEILFGDINFKTLPAERILIQKDDIILLPEWKYSALKVIERLERARRRAKALDELYAKGEITRQSYEEFKANVSKDLDTLKKDANEAKDMIKKRINELEDQIVQIEKAITALKMSYIAGEISERGYKPAADILRLNKDRNLEEKNDAKKIMDLIVKLETSSLDVESVVKEVQNVTPQVPQVEQPIVVELHESAPQSDNANVPAVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A083</accession>
    <name>I0A083_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <end position="149"/>
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    <sequence length="154" mass="17484" checksum="6CD065C250F31750" modified="2012-06-13" version="1">MSAPSQEKKSKELKLEAKQLITRDQVMQNPKLMKLLKLIDIYGEITEKGLNTLIYKLKEKGIQFDYTFFKVGNAIVSKSLKEDILALLYVEFLETAGRAKKLKTTSIGKEALSLVRIPENEMNELKKAVEELRGEIAMVEAEVELQSKHLGSKK</sequence>
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        <source>
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    </evidence>
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    <sequence length="69" mass="7650" checksum="48C5E2502F68CD06" modified="2012-06-13" version="1">MSKRLKSPYKACIKCKALVEPNVEVCPVCGSKEFTNDWEGLVIVLDVNNSKIAQILGITKPGKYAIKIR</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0478"/>
    <dbReference type="EnsemblBacteria" id="AFH42468">
        <property type="protein sequence ID" value="AFH42468"/>
        <property type="gene ID" value="FFONT_0478"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0478"/>
    <dbReference type="eggNOG" id="arCOG01860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036524_3_1_2"/>
    <dbReference type="OMA" id="IDDHDEW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="32"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="200" mass="22959" checksum="0A4989C5C63C7C66" modified="2012-06-13" version="1">MLTELKEEERNVLEVLKLLARSVMPQKDITHGIEHVERVVRLCLYIGEKVEEEVDTFVLLASAYLHDISRVSDDENHEALASEISEDILRKFGIREEKIKKISHAIRAHSFSSGIEPGSIEAKILSDADKIDAIGAVGIARVFAYSGKHERSLNESFEHFSRKILKLKDKMYTKPGKEIAEERSKFVERFLEELDREIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0G5</accession>
    <name>I0A0G5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0482"/>
    <dbReference type="EnsemblBacteria" id="AFH42472">
        <property type="protein sequence ID" value="AFH42472"/>
        <property type="gene ID" value="FFONT_0482"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0482"/>
    <dbReference type="eggNOG" id="arCOG03765">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1346368_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="203" mass="22974" checksum="7CD35622F34D3F36" modified="2012-06-13" version="1">MAKYIKLFLTKVLNLFLKKKLQDDAKMPLNRKIMAADQELAEKLSKLAEKYNTSLFNLTNKAISSYIIMEKSGYGDPVDGAVDLTIFQTLLSFGFKLEIPNLEGDEAKKAGRAVWILISSRVDGADKDKVLLRLLSLFVGEKNVFTETKNGEKRFVVSLPINPKVNEEALKDIIYGFLEEAYGRNRFEIENKAKLLIISIFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0H7</accession>
    <name>I0A0H7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytidylate kinase</fullName>
            <shortName evidence="5">CK</shortName>
            <ecNumber evidence="5">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytidine monophosphate kinase</fullName>
            <shortName evidence="5">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cmk</name>
        <name evidence="6" type="ordered locus">FFONT_0494</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the cytidylate kinase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0494"/>
    <dbReference type="EnsemblBacteria" id="AFH42484">
        <property type="protein sequence ID" value="AFH42484"/>
        <property type="gene ID" value="FFONT_0494"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0494"/>
    <dbReference type="eggNOG" id="arCOG01037">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_1_0_2"/>
    <dbReference type="OMA" id="FIFRDMA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00239">
        <property type="entry name" value="Cytidyl_kinase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011892">
        <property type="entry name" value="Cyt_kin_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02173">
        <property type="entry name" value="cyt_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="189" mass="21542" checksum="38FE4E069BA2BB87" modified="2012-06-13" version="1">MQLPNNVIVIGGPAGSGKTTYSTYIAKKLGFSYVSSGMIFRSIAKERGLSISELNELAEKDSSIDYYIDRRTLEEAMKGNVVLEGHLAPWIVSNIADLKIYFNASLKTRVMRIAEREKRNWKDVLIETAKREYSQAMRFKKMYGIDVLDLSIFDFIVSTEKLTIEQVKFIVDQIIEYAIENKKIQPASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0J6</accession>
    <name>I0A0J6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl29</name>
        <name evidence="5" type="ordered locus">FFONT_0513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0513"/>
    <dbReference type="EnsemblBacteria" id="AFH42503">
        <property type="protein sequence ID" value="AFH42503"/>
        <property type="gene ID" value="FFONT_0513"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0513"/>
    <dbReference type="eggNOG" id="arCOG00785">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_2_0_2"/>
    <dbReference type="OMA" id="TIMREEE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="67" mass="7797" checksum="26002B5346E2CCCB" modified="2012-06-13" version="1">MSMNADEIRKLTPEQRKEKLNELRLELSKLQMQAHVGTVDNPGKIKVLRKTIARILTIENEEKRKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0K1</accession>
    <name>I0A0K1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0518"/>
    <dbReference type="EnsemblBacteria" id="AFH42508">
        <property type="protein sequence ID" value="AFH42508"/>
        <property type="gene ID" value="FFONT_0518"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0518"/>
    <dbReference type="eggNOG" id="arCOG00441">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_898986_0_0_2"/>
    <dbReference type="OMA" id="ALYEWKY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="62"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="313" mass="35639" checksum="28ECF132C66249F9" modified="2012-06-13" version="1">MADSLTSETDPIEVKVRDIYEQAYPRIREVRNPIEAKKILREEYKLIVSEGLITLVFAAFIDGLPVLFEGPPGTGKTEIGEALLSLWAGRKAIILPCSENYDEYRVLGDFHPMKAYKEGFNEESFIPRPLLAALILDSGILIDEIRRSSEEFQNLLLDVIDKRRIIIPELKKVYKAKGIGFQLIFTSNPEDLAQNELSDAFMRRVVRIKLDYPPPDKEIEIIRLRLGTVSSLISEDMMMKGIEAINVLRKSDLMYKPGIADSVRWMGISARIAMLRGHERVSEEDLLEGAKATLLKRNDEEEAVIKIIKRFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0K6</accession>
    <name>I0A0K6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl3</name>
        <name evidence="7" type="ordered locus">FFONT_0523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0523"/>
    <dbReference type="EnsemblBacteria" id="AFH42513">
        <property type="protein sequence ID" value="AFH42513"/>
        <property type="gene ID" value="FFONT_0523"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0523"/>
    <dbReference type="eggNOG" id="arCOG04070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033361_2_0_2"/>
    <dbReference type="OMA" id="HQRTEYN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_A">
        <property type="entry name" value="Ribosomal_L3_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019928">
        <property type="entry name" value="Ribosomal_L3_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="PTHR11363"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03626">
        <property type="entry name" value="L3_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="347" mass="38612" checksum="C811F46AEEE2DD39" modified="2012-06-13" version="1">MGHRKKSAPRRGTLGVRPRQRFEGIVPRVRTWPVLEEKKIFPLGFIGYKVGMTHALVVDDRKTSITFGKQIFTPVTLLETPPMILAGIRGYSFDINEGKQPLTEAWATGDTLKNTNIERLIKSFSPNSTQQKLEELEKSLSEMAELRALLLSQPTLAGGISKKKPELIEVGLSGKDLKAQFSYAVEKLGKTIKISEIFNPGKFVDIIAVTKGKGFQGPVKRFGIKVLPRWHKHRKAARKIGARGPGMGALSTAPQAGQMGFHQRVDYNKRILYIADTEGKDKELLAKINPSSGWHKYGLIRTDFVILAGSIPGSRKRPVILRQPVRPPSWIPEGAPKITYLHKIGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0K8</accession>
    <name>I0A0K8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0525"/>
    <dbReference type="EnsemblBacteria" id="AFH42515">
        <property type="protein sequence ID" value="AFH42515"/>
        <property type="gene ID" value="FFONT_0525"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0525"/>
    <dbReference type="eggNOG" id="arCOG11397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3227663_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="43" mass="4684" checksum="9A396732AB7EE85F" modified="2012-06-13" version="1">MGGRQKTTLFMGVGGPTERVKKTESTQTEEKASKGKKAEKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0L1</accession>
    <name>I0A0L1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MFS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0528"/>
    <dbReference type="EnsemblBacteria" id="AFH42518">
        <property type="protein sequence ID" value="AFH42518"/>
        <property type="gene ID" value="FFONT_0528"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0528"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625016_0_0_2"/>
    <dbReference type="OMA" id="WFALTTI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="438" mass="47139" checksum="96B4C52357050F46" modified="2012-06-13" version="1">MVAVEELKMIEKSLEKAGMKLTPSLLIYISVVLMRAANASFIISLTTAFPDISAWMQGIIQASYSFTEALFGIFSGIIYEYLGSSISIIFSSSLLFISYAIMTVFADMSISAEAFTIPSALAGLSASFLLTSSLAVISEETIKASTKGRLFGVGGLEVSNIIGYAVGFTFAGTLQLILPSAIKGFSPSFLFSFLAFLSSIILSKSMGRRNISEFKNKKITFHLKAKIEGKVLKLVPMWFGFSIVMGVAFISPKFLSELFSPIEVSNPGLKLFSSFMLLFALIILSLGVMGGSYIASILGKVNSLLAGSLSLPSTLVMLSILVSYGSNIKGISMFFFTLILLIFSVLALSIPPTLLSLLADFTDLSRIRGPSSGVYVTSMGIGIALGESLGGKIYDVFGLETLLLILAIVFLPLGLSTWIMLYFERSRKNISSKPIPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0P5</accession>
    <name>I0A0P5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit PurQ</fullName>
            <shortName evidence="1">FGAM synthase</shortName>
            <ecNumber evidence="1">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Formylglycinamide ribonucleotide amidotransferase subunit I</fullName>
            <shortName evidence="1">FGAR amidotransferase I</shortName>
            <shortName evidence="1">FGAR-AT I</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutaminase PurQ</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase subunit I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name evidence="2" type="ordered locus">FFONT_0562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0562"/>
    <dbReference type="EnsemblBacteria" id="AFH42552">
        <property type="protein sequence ID" value="AFH42552"/>
        <property type="gene ID" value="FFONT_0562"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0562"/>
    <dbReference type="eggNOG" id="arCOG00102">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_3_1_2"/>
    <dbReference type="OMA" id="LHFVCRD"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00421">
        <property type="entry name" value="PurQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01737">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="224" mass="24837" checksum="F7C7DF31690F1255" modified="2012-06-13" version="1">MISFPGTNCDLDTVSAIKELTSLDAEIVWHKDFKGKKYDAIIIPGGFSYGDWLRAGAIAARSKAMEEVVEEAINGKPVLGICNGFQILVESSLLPGVLLPNELGRFICRWTRVSIENPKGPWLKLANKKEKIDMPIAHAEGRFYIDSEKFKAISNSSPIIYYENGWNPNGSFYDIAGIGNEEGNVLGLMPHPERAYTEILSPRGFHGNGGLFFKSLEDSLKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Q6</accession>
    <name>I0A0Q6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphate transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0573"/>
    <dbReference type="EnsemblBacteria" id="AFH42563">
        <property type="protein sequence ID" value="AFH42563"/>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0S1</accession>
    <name>I0A0S1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="10">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="10">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hppA</name>
        <name evidence="11" type="ordered locus">FFONT_0588</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH42578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
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            <end position="78"/>
        </location>
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        </location>
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        <location>
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            <end position="759"/>
        </location>
    </feature>
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        <location>
            <position position="514"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="764" mass="81485" checksum="5EEFFD56938FE5AB" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0T7</accession>
    <name>I0A0T7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FFONT_0604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
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        <location>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
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        </source>
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        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="623" mass="69365" checksum="B4DDC3D1CFBC5AB4" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="130" mass="14464" checksum="4CCA78D09CCE7B0C" modified="2012-06-13" version="1">MYLLDASAIINLIKNKKLEAFENASTTDLALYECLNAVWKEAFLLKRLKEETALKLAGSIAKIFSSIEAYSITGFEGEALNLALKEGITVYDAVYLYIAIRNGFTLVTDDEKLKDIASKYIKAMRSAEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
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    <name>I0A0Z2_FERFK</name>
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        <submittedName>
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    </protein>
    <gene>
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    <organism evidence="1 2">
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    <reference evidence="2" key="1">
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                <person name="Kublanov I.V."/>
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                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A110</accession>
    <name>I0A110_FERFK</name>
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        <submittedName>
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        <name evidence="2" type="ordered locus">FFONT_0679</name>
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    <organism evidence="2 3">
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        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
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                <person name="Kublanov I.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    </evidence>
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        <source>
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    <sequence length="398" mass="45924" checksum="71F793F2413D760A" modified="2012-06-13" version="1">MSNFDKIVERRGTGSEKWDFLSRTFGSDDLIPMWIADMDFQSPKPVIDAIIKRAEHGIFGYTDLTEEYYETVVNWFERRYKWSIKREWIVYTPGVIPAISTAIATFTNPGDKIIVQPPVYYPFFRSVESNGRRILANPLVLHDKRYEMNFRDLEEKAKDPRARMIILCNPHNPVGRVWRKEELERLGEIAIENNLIVVSDEIHSDIRYPGISFKNFASISEELADISITCTSPSKTFNLAGIKASNIIVPNRKMREMFRSSLEAMGISKPNVFAEEAVKAAYREGEGWLNDMLNYLKGNLDFLKRFVEENMPEVEVIEPEGTYLVWMDFRKVESDPKKLERLMRDIAKVALDEGYIFGSGGEGFERINIACPRSMLERALVQIADAVKRYKEGLVRFA</sequence>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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            <end position="142"/>
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    </evidence>
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            <dbReference type="EMBL" id="AFH42679.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="220" mass="24923" checksum="B3B4F12A882AA8CF" modified="2012-06-13" version="1">MVVLNDNEPSPGLRNDWGWSLFIEFNGREILFDADTRGEIIAYNSQKLNIDLSSIDFSFLSHYHGDHYGGYEYFEGKKSFKVYVPDKDRILRKLGLLPIVVEKFEEIEEGVFSTGPLSSLGLKEHSMVLKIDDLNILIVGCSHPGIDVIAKKVFERLGKIYFTIGGFHEPPLRALDRLAEVSEYIAPAHCSGSRAKEYVKKKYGKKYVSVRTGSEIILPF</sequence>
</entry>
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    <accession>I0A144</accession>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <text evidence="1">Belongs to the desulfoferrodoxin family.</text>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
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            <dbReference type="Pfam" id="PF01880"/>
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    </evidence>
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            <dbReference type="EMBL" id="AFH42701.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
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    <sequence length="124" mass="13897" checksum="3BEB6551FF62C92F" modified="2012-06-13" version="1">MKKFGEYIYSPEQASGEAISKVETHTPKIEAPESVKANEAFTVKISVGPHPNQVSHFIRSLTVYFVEEGRAFNPVHLATVEFEPEYSEPIITLTLKLKKSGTIYALGYCNLHGVWEGKKEVKVE</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="gene ID" value="FFONT_0739"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    <sequence length="208" mass="23821" checksum="7CB4B515D511B04C" modified="2012-06-13" version="1">MGYLNPTNIKDHLKGKVLSVVSSIYMPNSCIDFVLNPSEQNSAICFNDLFEYYDKEKVGLLSELVQNYKVNRIVELTPAGWIWPENIAIYIHGRFYELKCESDKEMIEITKDNLNKIEKCRGKRIIPVFSRGDEEKIIYSSIRSIMSSELLLVLGKVDIISPGSYLPWIAKNFGGIYIVEINQENSEVDKFADLKLNLSPIDFLKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
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    <gene>
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    </organism>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            <strain evidence="16">DSM 19380 / VKM B-2539 / Kam940</strain>
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    </reference>
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            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP + H(+)</text>
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    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + diphosphate + GMP</text>
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        </reaction>
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            <name>Mn(2+)</name>
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        </cofactor>
        <text evidence="10 11">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Monomer.</text>
    </comment>
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        <text evidence="1 11">Belongs to the RtcB family.</text>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
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    <keyword evidence="10 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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            <end position="397"/>
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            <end position="567"/>
        </location>
    </feature>
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            <end position="663"/>
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    </feature>
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    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="97"/>
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        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
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            <end position="675"/>
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        <ligand>
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        <ligand>
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            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="704"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
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        <location>
            <begin position="798"/>
            <end position="799"/>
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        <ligand>
            <name>GMP</name>
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    <feature type="binding site" evidence="10">
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        <ligand>
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        <location>
            <begin position="847"/>
            <end position="850"/>
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        <ligand>
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        <ligand>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50819"/>
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    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFH42742.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="949" mass="106850" checksum="BB55EBAC1D4F0CA2" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A199</accession>
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    </protein>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0768"/>
    <dbReference type="EnsemblBacteria" id="AFH42756">
        <property type="protein sequence ID" value="AFH42756"/>
        <property type="gene ID" value="FFONT_0768"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0768"/>
    <dbReference type="eggNOG" id="arCOG04320">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053595_0_2_2"/>
    <dbReference type="OMA" id="MNACIPP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00959">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028581">
        <property type="entry name" value="DeoC_typeI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="PTHR10889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF1">
        <property type="entry name" value="PTHR10889:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01791">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001357">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00126">
        <property type="entry name" value="deoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="239" mass="26473" checksum="8A1A960B6773B6FA" modified="2012-06-13" version="1">MIKIDLKSIPKNQEELARRIDHTVLKIDEKKNGIIRGLEEAEKYSFRSLVIPLCYVKEFSSLSKVPISAVISFPFGQDPLEIKQKQIELAFSNGAKEVDVVINVMSYISGDKSYVENEIKKLSDLTHELGGKVKFIIETGYLDNAGIAELSKMIEKSNGDYIKTSTGFGPRGVNIDDILVIRSAVSREQKIKASGGIRSGIQALLLLAFGANILGASQSVKIVNEYPQALRMFESVYNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1B3</accession>
    <name>I0A1B3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ahcY</name>
        <name evidence="8" type="ordered locus">FFONT_0782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0782"/>
    <dbReference type="EnsemblBacteria" id="AFH42770">
        <property type="protein sequence ID" value="AFH42770"/>
        <property type="gene ID" value="FFONT_0782"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0782"/>
    <dbReference type="eggNOG" id="arCOG04137">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_2"/>
    <dbReference type="OMA" id="NKYGCRE"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="7">
        <location>
            <begin position="185"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="214"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="293"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="416" mass="46305" checksum="9B50434FA7798020" modified="2012-06-13" version="1">MPEYWVSDINKAEEGVAQLEWAERNMPVLMSLRKKYSDEKPLRGAKIAACLHVTKETGVLVRTLKAWGAEVYLAASNPLSTQDDIAAALATEGVCVFAKKGESEKEYFWAIEKVASIHPDIVIDDGADLHSLLHEKHPEMLNKIKGGAEETTTGVVRLRALEKEKKLGYPVFAVNDAMTKQMFDNRYGTGQSTIDGLLRATNILISGKTIVVAGYGWVGRGIAARARGMGAEVIITEVDPVKALEAVMDGYRVMKMEEAAKIGDVFITATGDKDVITWKHMEKMKDGAILANSGHFNVEVSVKDLEENSISSRELRRYMKEYKMKNGKVLYLLAEGRLLNLVAAEGHPSEVMDMSFANQALIAKKVWTEPRLEPKVYKVPLDIDQNIAMLKLKSMGIEIDELTPEQKEYLDSWKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1C8</accession>
    <name>I0A1C8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FFONT_0797</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HerA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0797"/>
    <dbReference type="EnsemblBacteria" id="AFH42785">
        <property type="protein sequence ID" value="AFH42785"/>
        <property type="gene ID" value="FFONT_0797"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0797"/>
    <dbReference type="eggNOG" id="arCOG00280">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023842_2_0_2"/>
    <dbReference type="OMA" id="CLVSQRP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018538">
        <property type="entry name" value="HerA_barrel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002789">
        <property type="entry name" value="HerA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="PTHR42957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01935">
        <property type="entry name" value="DUF87"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09378">
        <property type="entry name" value="HAS-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAS-barrel" evidence="11">
        <location>
            <begin position="17"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DUF87" evidence="9">
        <location>
            <begin position="154"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="DUF853" evidence="10">
        <location>
            <begin position="403"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF09378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH42785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="552" mass="62670" checksum="C502834B490A1AB7" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1D3</accession>
    <name>I0A1D3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mevalonate kinase</fullName>
            <shortName evidence="4">MK</shortName>
            <shortName evidence="4">MVK</shortName>
            <ecNumber evidence="4">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mvk</name>
        <name evidence="8" type="ordered locus">FFONT_0802</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0802"/>
    <dbReference type="EnsemblBacteria" id="AFH42790">
        <property type="protein sequence ID" value="AFH42790"/>
        <property type="gene ID" value="FFONT_0802"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0802"/>
    <dbReference type="eggNOG" id="arCOG01028">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017814_0_0_2"/>
    <dbReference type="OMA" id="NTVCTYG"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00217">
        <property type="entry name" value="Mevalonate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022937">
        <property type="entry name" value="Mevalonate_kinase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="PTHR43290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GalKase_gal_bdg" evidence="7">
        <location>
            <begin position="4"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_N" evidence="5">
        <location>
            <begin position="104"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP_kinases_C" evidence="6">
        <location>
            <begin position="238"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="335" mass="36455" checksum="BC095BEB99C972FC" modified="2012-06-13" version="1">MNKKVIASAPGKVTLFGEHAVVYGYPALVVSIDKRIYAIAEKRNDDVIKINARDLRVPGIVISYIGNEVVLETDYGLILPAIAYINKAIEVTSKYIGTKAGVNIEIRSEMPVGAGLGTSAAVAVSTIAAYAYVNEYELKKEEIANLGWQVEKEVQGIASPMDTSITAIGGFLKIKYIDKTVERTPIEVKEEIPLLIGYVERESRTKDMVAMVRKKIESYPEIYMKIMELIGNTVEKAESALLNNNLHELGSFMNLNHSLLDALGVSTRRLNELVYVARDAGAYGSKLTGAGGGGCVIALTPENQDVIETAMKLHGTLTFRTKLGTDGVKIESVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1D7</accession>
    <name>I0A1D7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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                <person name="Gumerov V.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0836"/>
    <dbReference type="EnsemblBacteria" id="AFH42824">
        <property type="protein sequence ID" value="AFH42824"/>
        <property type="gene ID" value="FFONT_0836"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0836"/>
    <dbReference type="eggNOG" id="arCOG00348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075000_1_0_2"/>
    <dbReference type="OMA" id="VGAVHEN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019151">
        <property type="entry name" value="Proteasome_assmbl_chaperone_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038389">
        <property type="entry name" value="PSMG2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09754">
        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="246" mass="26715" checksum="C8529B4B6D127C94" modified="2012-06-13" version="1">MIEKNDTKNLRGKTLIVGFPGMALVGKATADFLISKMKLEEYVEFFPVQSPSSVIVMDGIIQPLSIKLYSSSSLQIAVLTASFQPQGEEAQTALAFDLSKKLVDLGFSKIISAAAYVSPEIKNGRKVFVAATNKEFIDELSKVGCVPMNGGISGLNGLIPALAEMYGIEGAVLLGETSEVYVASNVVDYMAVGEILRVLSSYLKFEIDLEDLTSKAKDIDEKIKKAMEKGFQEVAEEKEEQPSTHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1G8</accession>
    <name>I0A1G8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aspartate--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="6">AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">aspS</name>
        <name evidence="8" type="ordered locus">FFONT_0837</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0837"/>
    <dbReference type="EnsemblBacteria" id="AFH42825">
        <property type="protein sequence ID" value="AFH42825"/>
        <property type="gene ID" value="FFONT_0837"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0837"/>
    <dbReference type="eggNOG" id="arCOG00406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_1_2"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="PTHR43450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="149"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="6">
        <location>
            <begin position="195"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="225"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="412"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="441" mass="50890" checksum="25DCCE92FF10586E" modified="2012-06-13" version="1">MSSSLKERIRIADVFSKNNGEKVLIAGWIEAVRIIGGVIFIVLRDRSGKVQAVIKKNIDEKLFNEASELGSEDVVAIKGEVKEAKTSLGDREIVVEKLYTISRATKPVPIVPEDWEKTNINVRLDWRFLDLRATRNRLIFVVTDEAVNALREFYRSNGFIEVFTPKIVSEATEGGAEVFPVIYFDKPAFLAQSPQLYKQMMMAAGFERVFEVGPAYRAEKHHTNRHLTEYESVDIEMSFIDSHEDVMKMVENAVIYSIKKVNEKYGSYIKQYFPRIPEIPSNVPRITLREAHKLLENKGFKQPDPNDLDTEGERLLGEIMEKEYGSQLFFVTEYSWLYRPFYTMKKPEEPSLTRSFDLIYRGTEIVSGSQREHRADVLENQIKEKGLNVKNFEFFIKFFRYGMPPHGGAGLGLERLVQMMLGLKNIREVRLLPRDPERLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1G9</accession>
    <name>I0A1G9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0838</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0838"/>
    <dbReference type="EnsemblBacteria" id="AFH42826">
        <property type="protein sequence ID" value="AFH42826"/>
        <property type="gene ID" value="FFONT_0838"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0838"/>
    <dbReference type="eggNOG" id="arCOG02103">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1286313_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="214" mass="24567" checksum="A9B3E5FE0C4DD53A" modified="2012-06-13" version="1">MNSSGSSEIHDICSLINTIDEISKNECQVPPDLIFFILYLLSINKSIGRSQISTVFGFSEYYVRRALKCLKDKAYILQTGKIKSLEENLLSVLKSIRIREAFLLRGMNAWERIIIIFIAQSCKRRISLKETVMLRDSAIRWGAEGSIILQYCNMETNIPGIEDLSIRNEIEKEIKKELQKLENGLYIIIGMNYKEREMSVVYGILKTACELSLI</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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    </evidence>
    <sequence length="121" mass="13880" checksum="C80C0D71180C185B" modified="2012-06-13" version="1">MSKDDVVKKSAELLRQGATMLSLTCPICGSPLFKLKNGDIVCPIHGKVIIARDEREVKEKLSVNIYDSIIEIAYKRLKELSKKIIDSEDMENESKIADLLYKWMNIIEKAKRLKEEQSKQI</sequence>
</entry>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="72"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021121"/>
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    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
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        <source>
            <dbReference type="EMBL" id="AFH42847.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="76" mass="8256" checksum="F24424E17DFB0EAD" modified="2012-06-13" version="1">MSDTAHKILSSSMGQTVLVKLKGNKEVRGKLKSYDHHLNIVLEDAEELFPDGQARKLGTVIIRGDNVIIISPASNG</sequence>
</entry>
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    <accession>I0A1J1</accession>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
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            <end position="148"/>
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    <evidence type="ECO:0000259" key="1">
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        <source>
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        <source>
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    <sequence length="154" mass="17599" checksum="5EDAEE8BBA58D57F" modified="2012-06-13" version="1">MRRHYLSKKEKDEILKEVNSKLKISLEPEKVEILESKEFSCYLFDSVPALCKTEDKFFPHLKYLLKHRDTILPKIFVDKGAVKPVSSGADLMAPGIVRIEGDFLPGDIVIVEDLEHKLPIAVMIAEMSSAEMKVTKKGRVARNIHYVGDKFWNV</sequence>
</entry>
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    <accession>I0A1L4</accession>
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    <reference evidence="4" key="1">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01613"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42871.1"/>
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        <source>
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</entry>
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                <person name="Gumerov V.M."/>
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        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42913.1"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="227" mass="25962" checksum="E1CA6B9832B04422" modified="2012-06-13" version="1">MSKSNENGEWVCSCPICRRIVYPLLKKKKKVKEKVEKEPTQNEKNSIDSLKEVVDALKESVAELKATIGDLSNPLFSLSSEAKQKEAKEVEKSTEKQVQMPKEEIRENKEEVEEVKTPVKRREPVLFKETVKMLKILYSLSEKMPGDMIDDYISLMKEIGISEEKTLDVIRLLNQIVQKGIKSNISLQDQLLSIYILSKAMGFSEPEIEEEVAQILIDYIKKGDKQG</sequence>
</entry>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <source>
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    </evidence>
    <sequence length="43" mass="4675" checksum="5CB6AB6A4448C860" modified="2012-06-13" version="1">MGENPITDPKIVYPTADATSDGSITSVSKSFLYIIFLQQEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1S5</accession>
    <name>I0A1S5_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0944</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42932.1"/>
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    </dbReference>
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        <property type="gene ID" value="FFONT_0944"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="39" mass="4385" checksum="12B7D253D498504F" modified="2012-06-13" version="1">MIFDDEKIDEISPYTKWYILGIILGVAAGLSALAFYFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1T7</accession>
    <name>I0A1T7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NERD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0956"/>
    <dbReference type="EnsemblBacteria" id="AFH42944">
        <property type="protein sequence ID" value="AFH42944"/>
        <property type="gene ID" value="FFONT_0956"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG03727">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OMA" id="AVDCKHW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011528">
        <property type="entry name" value="NERD"/>
    </dbReference>
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        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08378">
        <property type="entry name" value="NERD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NERD" evidence="1">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="221" mass="25311" checksum="E513E364CD0B7FEE" modified="2012-06-13" version="1">MESIVNYLLKENKATISYLAEISLTNEFLVKKLIEDLRGINIEDGIVSVENRLELAISAIHKGISPYVVSRYLSWKDFEKELSEILEQYGYEVLRNYRIRKPSRAEIDIVAIKTGLALIVDCKHWSPRSASRGRIEFAANKQVERTKLLLENEEFLLLLGNKACIRRPCEVKLVPVLVTLVSKNYGLLNSVPVVPIKSFLNFLIEIDKLLELIIRISVKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1V2</accession>
    <name>I0A1V2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0971</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH42959">
        <property type="protein sequence ID" value="AFH42959"/>
        <property type="gene ID" value="FFONT_0971"/>
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    <dbReference type="eggNOG" id="arCOG03754">
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    <dbReference type="OMA" id="RSGWIWI"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="537" mass="59278" checksum="D7E7DD6FD66B4C42" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1X2</accession>
    <name>I0A1X2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribose-phosphate pyrophosphokinase</fullName>
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            <ecNumber evidence="3">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
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        <alternativeName>
            <fullName evidence="3">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="3">P-Rib-PP synthase</shortName>
            <shortName evidence="3">PRPP synthase</shortName>
            <shortName evidence="3">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prs</name>
        <name evidence="7" type="ordered locus">FFONT_0991</name>
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    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="3">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family. Class III (archaeal) subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0991"/>
    <dbReference type="EnsemblBacteria" id="AFH42979">
        <property type="protein sequence ID" value="AFH42979"/>
        <property type="gene ID" value="FFONT_0991"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0991"/>
    <dbReference type="eggNOG" id="arCOG00067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_2_2_2"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
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        <property type="entry name" value="Pribosyltran_N"/>
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    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 4" id="KW-0545">Nucleotide biosynthesis</keyword>
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        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="151"/>
            <end position="267"/>
        </location>
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    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="3">
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            <begin position="220"/>
            <end position="224"/>
        </location>
    </feature>
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        <location>
            <position position="189"/>
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        <location>
            <begin position="35"/>
            <end position="37"/>
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        <ligand>
            <name>ATP</name>
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            <end position="95"/>
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        <location>
            <position position="128"/>
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        <ligand>
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        <ligand>
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        <location>
            <position position="191"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:78346"/>
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        <location>
            <position position="216"/>
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            <dbReference type="ChEBI" id="CHEBI:78346"/>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF13793"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="292" mass="32716" checksum="7A420BF211306EC8" modified="2012-06-13" version="1">MDIILCGTKSDWFCDNLSKSLNIKSLKVFHKVFPDGETYIRVPEEVSGKKVILAHSLSPPQNDSIWELILILEALRELDIKEINGYIPYVAYSRQDKIFLNGEPISIKALLQILSQMGMSSIYTIDIHKPNTLSYFNGTSYNIIPFKSMANMIRNMAKHPFVISPDIGALERARRLANELSTDFDYMEKKRDVYTGKIEISFHEVNLKDRDVVIVDDIISTGGTVAEAAKKIYSLGAKKVFVAVSHALLAGDAINKLKEANVYSVLSANTLPPKSGVIYYDVIPELAEILKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Y1</accession>
    <name>I0A1Y1_FERFK</name>
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        <recommendedName>
            <fullName evidence="13">Vitamin B12-dependent ribonucleotide reductase</fullName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">FFONT_1000</name>
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    <organism evidence="15 16">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="16">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH42988">
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        <property type="gene ID" value="FFONT_1000"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="MMATMRC"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:cobalamin binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RIBORED_LARGE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="11 13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="7 12 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="15"/>
            <end position="110"/>
        </location>
    </feature>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFH42988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="853" mass="96912" checksum="ED29435E9722B17D" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Y2</accession>
    <name>I0A1Y2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="13"/>
            <end position="202"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="295" mass="33126" checksum="97544D772443B303" modified="2012-06-13" version="1">MEKSSKFLIFKGRTNVLIVTNDNKEAIIVDTGIDEDSGRKIAKFLNQNSLTPVAIINSHSHADHIGGNSYLEKKFKIQSYSTKNECAFIENPLLEPLYLYEAFPPESLTIKTLAAEPSSCNSIEEFNINEFGIEIIRLPGHSIDMIGLKIGGELLFTADAFFGIDTLIKHKIPYHVNVKNSYLTLLMLKEEVKKFNAVLPSHGDLIQSQSEAEDAILKNINAILEVRDLIVNSFESKKEVESVISQVLNHYGFSNVPLAQYFLLKSAIMSYFAWLLDEKILSLETEDGRLVAKKI</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="MetI-like_sf"/>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="266" mass="28674" checksum="942CACA330AFE711" modified="2012-06-13" version="1">MSTKFSLFLLTFIILSGILLLFFSYPIAVIFAVGISGALSSFKITQFELGLLITIIASSLAALASIVFGIPLAYILARYNFRFKEVIETIVDIPIAVPHMIVGIMIVLSFAQYYGFGALLQTLGIKVIDTIFGAVLAVLYVSSTYAVRIIESAIKGLDPEIENVALSLGAPRAITFFSVVIPNIKKALANAILTSWARASSEAGALLIVAYQVNFAGNFVYPASVAIYEAYVGLGVLEAARFSVAMLILILGIYLATRAVLRWKVE</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="InterPro" id="IPR017006">
        <property type="entry name" value="UCP032756"/>
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    <dbReference type="Pfam" id="PF10051">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="164" mass="19018" checksum="07AC6867FBA7864E" modified="2012-06-13" version="1">MSGNKQSFIIINAHSGKVKDKKIVEGEFEEVVKNAGKEFLLNEWLPSFSDFMILRDIFEVELKSSLPKEVISKYKEYNLKRKDKDTLVATLPVYLIVYESLKISEDSYHDRGVSVVAPYIREEDAQLLSELLIETTKKPTLEEIEKEENIAEELEEEDEDVEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A200</accession>
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        <submittedName>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_1019"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ni-dep_hyd_lsu"/>
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        <property type="entry name" value="NiFe-Hase_large"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="423" mass="48920" checksum="9C21FA8CC4201059" modified="2012-06-13" version="1">MEKSSLSLLTRVEGEGRANIVVGDGKIKRIEVHIFEAPRFIEFGLKGRKPIEAPEITSRICGICSVSYQMASAKAFEYGMGIEVPYEEEEMRKAIFINEHIKSNVLHVLYLQLPDLLNASSSLEVFNKNPEIYKMATDLFMWSRKLMKVLGGRFHNIVNIRVGGVYSMPEKKEVEALSSQSERAITYARKLSEFVLDNQDKFPSYEQKIKPLVLCDSIEYPFISRNICSDEMRFEISKFEEEVVPEQVPYSNSLRYRLRSGENYVVGPISRFNTSFYNLRGEVRRMLKSYGYMPPLKNMSYSIVARIAELYEFILRITDFIDNYRYVQVNEKSFEIKEGTYYGAVEAPRGILYHRYTVNKRGLIEDANIIPPTSQNLISMEAFSMYHLEKIGLINKAEQLEKAHQEVQKIIRLFDPCISCSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A216</accession>
    <name>I0A216_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="4">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">dtdA</name>
        <name evidence="5" type="ordered locus">FFONT_1035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DtdA deacylase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1035"/>
    <dbReference type="EnsemblBacteria" id="AFH43023">
        <property type="protein sequence ID" value="AFH43023"/>
        <property type="gene ID" value="FFONT_1035"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1035"/>
    <dbReference type="eggNOG" id="arCOG01616">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056464_1_0_2"/>
    <dbReference type="OMA" id="CYEATHH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00562">
        <property type="entry name" value="Deacylase_DtdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018033">
        <property type="entry name" value="Deacylase_DtdA_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007508">
        <property type="entry name" value="DtdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34667">
        <property type="entry name" value="PTHR34667"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04414">
        <property type="entry name" value="tRNA_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016210">
        <property type="entry name" value="UCP016210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="262" mass="29816" checksum="B925734B1759107E" modified="2012-06-13" version="1">MRALVTFSYQDPAGVGMAEELKKISGSEIEIKGFDVNDVEFSFLEDFKEYNAFIVLSMHMSEAGIPCLTVHHTGNLTSKALLGGRPREISVSFPRLSGFLIKKIHSLVSYYGLAEKMKVSYEATHHGPTNITRPLVYVEIGSSEKEWKDKELQKLMAEAVYDAYMLLKEDRLPDCEKAIGFGGGHYSERHTKISIENNVCFGHLVPKYAIKEGIDSFVLDQIYDKNYEGINSVYAEKKIGTREFREEIEKKAKERNVKFVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A249</accession>
    <name>I0A249_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transcription regulator, containing DNA-binding HTH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1068"/>
    <dbReference type="EnsemblBacteria" id="AFH43056">
        <property type="protein sequence ID" value="AFH43056"/>
        <property type="gene ID" value="FFONT_1068"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1068"/>
    <dbReference type="eggNOG" id="arCOG04060">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077869_0_0_2"/>
    <dbReference type="OMA" id="KMAGEIT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017271">
        <property type="entry name" value="Tscrpt_reg_HTH_MJ1545_prd"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037724">
        <property type="entry name" value="TF_HTH_MJ1545_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="235" mass="26366" checksum="11E92AC59277F514" modified="2012-06-13" version="1">MISDFIIERISKEIAGEIAWSENPGEAMKKWRRIFNVTQLEISKKMGVFSSVLSDYEKGRRSPGSKFIRKFVISLLEIDEKRGWITVKELARNLRLPATALLDIREFTKEVTLEKVVEAINGEVLYGKDELNKYIYGYTVLDSIATIETLSGYEFLTIMGLTTERALIFTNVGTGRSPMVAVKVSFLKPRAVVVHGPKVVDPLTIKLAQSDGIPFILSRAPDVNTLIKNLKSLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A256</accession>
    <name>I0A256_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt transport ATP-binding protein (CbiO)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1075</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1075"/>
    <dbReference type="EnsemblBacteria" id="AFH43063">
        <property type="protein sequence ID" value="AFH43063"/>
        <property type="gene ID" value="FFONT_1075"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1075"/>
    <dbReference type="eggNOG" id="arCOG00202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="DMVPCEL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="221" mass="24943" checksum="49E77C7A89A6A3C3" modified="2012-06-13" version="1">MNLIAKLLNVSYAYPDGTKAVKNVSLELRRGNVICITGPNGSGKSTLLMILAALIFPQEGEVYLFGKKIDKKNASEVRKKIGFLFQNPDDMLFNPSVIEEISFGLIAKGVNREISNNLALEEMKKLKIENLAYKVPHRLSFGQRRLVSLASILVTDPSLLLLDEPTSNLDEKNRELIIERLMEFFGNRKDDWGAAIATHDNELIYICNEFFYMSEGELSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A284</accession>
    <name>I0A284_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Citrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FFONT_1103</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CitM (TC 2.A.11) transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1103"/>
    <dbReference type="EnsemblBacteria" id="AFH43091">
        <property type="protein sequence ID" value="AFH43091"/>
        <property type="gene ID" value="FFONT_1103"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1103"/>
    <dbReference type="eggNOG" id="arCOG00238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011920_3_0_2"/>
    <dbReference type="OMA" id="SWGYYFK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000802">
        <property type="entry name" value="Arsenical_pump_ArsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00758">
        <property type="entry name" value="ARSENICPUMP"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="CitMHS" evidence="10">
        <location>
            <begin position="7"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH43091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="395" mass="43683" checksum="CCEA6F2BCE8086AE" modified="2012-06-13" version="1">MSFLAFLSVAGGLVNIEEIPSAIDLNVIFFLIGMFSIIALAESSGLLDLLSHYVISKFKSTYAAIIGTFAFFGLLTSVAVNDTMAVMAPPIVYFISKHLKIPYRQLLILLAFSITIGSVMTPMGNPQNVLIAIGSGMSAPFIYFIEYLFLPTIINLVITSFLVIKIYKIPNNSIDIGTIPEEKIKNKKDAILAAIGIFSVIVAMIVNDILRVMGKPSIEQIGFIPFIIASSLYFFVSEPRSLIKEVDWGTIIFFITMFIAMDGVWKSGVASELLRVFIPSKPSDTIAPVLISIISIILSQLFSNVPFVKLFMDYMRELGYTANNIVPWISLAMSSTIAGNLTLFGAASNIIILEISESRYKETIPFSEFFKIGFPVTLLNLTIYLFYIYLTSYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>I0A287</accession>
    <name>I0A287_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1106"/>
    <dbReference type="EnsemblBacteria" id="AFH43094">
        <property type="protein sequence ID" value="AFH43094"/>
        <property type="gene ID" value="FFONT_1106"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1106"/>
    <dbReference type="HOGENOM" id="CLU_3002987_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="56" mass="6661" checksum="09C7015125706CF2" modified="2012-06-13" version="1">MFYIPIIVHIIFINSTVPFKIFIEGIPRENGILIKAYYITILIKKRYENTLINFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A288</accession>
    <name>I0A288_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1107"/>
    <dbReference type="EnsemblBacteria" id="AFH43095">
        <property type="protein sequence ID" value="AFH43095"/>
        <property type="gene ID" value="FFONT_1107"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1107"/>
    <dbReference type="eggNOG" id="arCOG00915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OMA" id="VYSSMDR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="453" mass="50876" checksum="216CE9D6ACEA7465" modified="2012-06-13" version="1">MEQEKRILNEELIEKYWKYIGVGISFKYFPIVIKKSKGCRIWDIEGREYIDFLTSAASFNIGHTNDEVVKAIKQAIDDMIDYDQYLYHEPSIRLAEMLVNIVPGSYEKKVLYELSGGAANDMALKVALAFTGRKYIGSFEDSYHGTHYLVLSSSGSFKPETRYKYNAYPYVYFFKYPDTFRRPRGIEPEEYGEILLGEIERTLQVDAYGKGFAAIIFEPIQGDGGVLVPPKSFIVGLRKIADEYGIVLIDDEIQTGFGRTGKMFAIEHFGIEPDVVTLGKNLGAGFPMSAVVGRKEIIDSGPPNTLGSNASGHYLGSIAAMAGIEYIIKNRLHDRAELMGEYLMKRLNELKDGHEIVGDVRGKGLMIGVEIVDDKDSLKPSSKKAQKIIWRAYENGLIMMTFGKYGNVLRIAPPLTIEREEIDKAVEIMEKAISDVEKGKVGDEVLSKMVAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2C7</accession>
    <name>I0A2C7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ser/Thr protein kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1146"/>
    <dbReference type="EnsemblBacteria" id="AFH43134">
        <property type="protein sequence ID" value="AFH43134"/>
        <property type="gene ID" value="FFONT_1146"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1146"/>
    <dbReference type="eggNOG" id="arCOG01182">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095575_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="254" mass="29821" checksum="DD2F76A520F46696" modified="2012-06-13" version="1">MRLMESLKYVICFPFNDKYAKKCLEIEEVIEKILDLEGRKLTLLAKGTDSIVLSLDEKYALKVVRLDREISLLKEGMSLYILERNFKKTGIKIAPELYSFSKYHVLMERINGISISDFIFSASEDELKDALRSLLIYSLKLDSIRLSHNELSRPYHHVFFIKNREKITPIFLDFGSSTINGNNSNFLQISSALFLSKSRINERITKSFKIDEIKQNKLRELLILYKNCFKKRCMQEEIEKVIEKILNIIFRQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2H4</accession>
    <name>I0A2H4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1193"/>
    <dbReference type="EnsemblBacteria" id="AFH43181">
        <property type="protein sequence ID" value="AFH43181"/>
        <property type="gene ID" value="FFONT_1193"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1193"/>
    <dbReference type="HOGENOM" id="CLU_2461638_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="88" mass="10367" checksum="3809846F28765994" modified="2012-06-13" version="1">MSFSAKKVARSVFVILPILAYGWFGFIAITFLMKVIFLYIQSENVEVVILRFVVFGAFVVFWLYSWWKFTVYYKKKIFVGQKLSSNIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2H8</accession>
    <name>I0A2H8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1197</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1197"/>
    <dbReference type="EnsemblBacteria" id="AFH43185">
        <property type="protein sequence ID" value="AFH43185"/>
        <property type="gene ID" value="FFONT_1197"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1197"/>
    <dbReference type="eggNOG" id="arCOG06101">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2550193_0_0_2"/>
    <dbReference type="OMA" id="VITWIEN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="85" mass="10087" checksum="775CD97DE07AC0F7" modified="2012-06-13" version="1">MQEEYCKEPPCIHVVSNDRKKIFAVFFEDSEGVITWIENRKMKEALQKIREAESKGYREATQDELDNLAREKLGVEPIPEEEEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2I9</accession>
    <name>I0A2I9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protease HtpX homolog</fullName>
            <ecNumber evidence="11">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">htpX</name>
        <name evidence="13" type="ordered locus">FFONT_1208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="11"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1208"/>
    <dbReference type="EnsemblBacteria" id="AFH43196">
        <property type="protein sequence ID" value="AFH43196"/>
        <property type="gene ID" value="FFONT_1208"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1208"/>
    <dbReference type="eggNOG" id="arCOG01331">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_4_2_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 11" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="12">
        <location>
            <begin position="114"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFH43196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="378" mass="42240" checksum="D047F9E16CFB42B2" modified="2012-06-13" version="1">MLLFLISPYFFFGMLIASLLTAGIIGILAVSADKIVRGPPKSLTGLKTSMAVTAIVTFLGSISLIYLVGVYFLGYGFSWLYFTVGLVAIFMILQWLLSPYMIKAVYRASEPKPEESWVSEMVTKMAKDAGLKSIPKAVIAEVPAPNAFAFGSPIAGNYVAITRGLLQLFPKEEIEAVVGHELGHLKHRDVATLLAISLLPSAIYFIGRMLLAWGWLAGDSRERGGGAMFYVLIGAILFVAGFLFQFLVTHFSRLREYFADYHSAKLTGNPRMLQRALARLTLIYESNPNVSNQINKSAAMLFIVNYFVSMSGGMAYENIDYWFPYSKKPYIPKDINIDEAVEKIMNRKESAFLELFSTHPSTPKRLRFLENLRNKVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2J4</accession>
    <name>I0A2J4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase (NDP forming), beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH43201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1163730.FFONT_1213"/>
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    </dbReference>
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    <dbReference type="OMA" id="FGPAIMF"/>
    <dbReference type="Proteomes" id="UP000007391">
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="238" mass="26254" checksum="3E011BB644CE0118" modified="2012-06-13" version="1">MNGGLKMSEQIKKIVENAKSSGRKKLLEHESLAVLEAYNIPVAPYFFAKDENEAQRNIDKIGFPVVVKIVSPDIVHKSDVGGVIVNVNSKDELVNAIKSIRANVQKNAPSAEVTGFLVQKMMPKGGLEVIVGGIRDPVFDATVMFGLGGIFVEVLKDVSFRIAPITKEEALEMINEIKARKILEGYRGEAPRDKEAIADIIVKVSKLLYENQELKEMDVNPVIVYEKGAYAVDARFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2N3</accession>
    <name>I0A2N3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1252"/>
    <dbReference type="EnsemblBacteria" id="AFH43240">
        <property type="protein sequence ID" value="AFH43240"/>
        <property type="gene ID" value="FFONT_1252"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1252"/>
    <dbReference type="eggNOG" id="arCOG00452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478858_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="182" mass="20933" checksum="69C29AF1C0F3CC31" modified="2012-06-13" version="1">MFGKKIDKTKMAKAITQLRLMENKLRMIEDRLQNSIDSKMNELLKYNQLYGVDAAKMIAGEIAEQKKVLFNIRNMRTSVERVRIRFETVMDLNGSVEMLKDVVPLVNDLKKSIVKAYPDLSIMFNDFEEKLNQIGLEIDSSELLNNPQIPMSEGMNEDVEAILKEAEEVAKTREKNRLPSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2W3</accession>
    <name>I0A2W3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FFONT_1332</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1332"/>
    <dbReference type="EnsemblBacteria" id="AFH43320">
        <property type="protein sequence ID" value="AFH43320"/>
        <property type="gene ID" value="FFONT_1332"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1332"/>
    <dbReference type="eggNOG" id="arCOG01185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063953_2_0_2"/>
    <dbReference type="OMA" id="HKLYMEY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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        </source>
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</entry>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_0030"/>
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        <property type="taxonomic scope" value="Archaea"/>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833194_0_0_2"/>
    <dbReference type="OMA" id="DPNVWAF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002808">
        <property type="entry name" value="AdoCbi_amidolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01955">
        <property type="entry name" value="CbiZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="302" mass="32604" checksum="13AC56367DE79EA2" modified="2012-06-13" version="1">MGIDIEESAIFLTAVDLKKYSRGSSSYKGVEAEAFVTYGVDSPSCFEGAERGKFGTINVAVIVDEPLSDVGLLDLFRTVSEVKGMIMSLGGPMCYSSSYVGTPSDATMVASPFGGERFAGSATDVGISASLAVLRALSEQIRNAPVDEHTAKTLGFKDIDEVVKLAVRAYRKAPIPFLSELDAEEEIKEEIDSILKDPNLRIIIRSARLAESFLSFGLLPGIEAEEYSSDSSGIIADEVMGKAIAEYLNGFKGLLAYYWIDRIKEGDKDLEDLSGLPLMTDDVVGAIVGGVLSRIYDKYSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ83</accession>
    <name>H9ZZ83_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0044"/>
    <dbReference type="EnsemblBacteria" id="AFH42040">
        <property type="protein sequence ID" value="AFH42040"/>
        <property type="gene ID" value="FFONT_0044"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0044"/>
    <dbReference type="eggNOG" id="arCOG03333">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143943_2_0_2"/>
    <dbReference type="OMA" id="RMCCLSA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014958">
        <property type="entry name" value="DGC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08859">
        <property type="entry name" value="DGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="151" mass="16513" checksum="10D95B0459F64693" modified="2012-06-13" version="1">MSSEKTSKYQLLPSCSTYAEGLIIVATCDGASSTGQIGNEVARMLTKTFPDKVRMCCLSAVASGSKLHLDIFKKARAVIAINGCQLMCASNVLKQKGIQPTYEITVAKEGINKLPTLDFDEEDVRKIANKITEEFLNRFLSKTGEAQENRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ98</accession>
    <name>H9ZZ98_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0061</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0061"/>
    <dbReference type="EnsemblBacteria" id="AFH42055">
        <property type="protein sequence ID" value="AFH42055"/>
        <property type="gene ID" value="FFONT_0061"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0061"/>
    <dbReference type="eggNOG" id="arCOG05814">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_680789_0_0_2"/>
    <dbReference type="OMA" id="KDITICD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="404" mass="44856" checksum="AE27DD7C42970FCF" modified="2012-06-13" version="1">MVRTMGERGFIMKIPPFEFQTARRLSLYFASFMAGYAPSGVNIAGDSLVFSGSPDLVLNGAFSSITNMYKSKLLATNSERLPCPRIKLNINDYKWVAQRLSSKLGFSISDDDTICSFFKKVVDSMPMYISRIGNIALETELKSINLSGDTLYLGGDMADFAQLQVLKLEKYEYGRNYLSLKFKGDMKISPLWYGILGGGWLASFSGYFGDTLLSLLIDENLILSEIQNIGSASVITSVIEDFSEAPIKVKEPPSHGEAYTLLLFLNMSPQILGRAGVISLSYQRISVGNNAYIVTEEIPISLSSLYQMLQPLITGVEYGTLKKSIEDLLKCTLRSAAGRSSAICQEKWGDLSTMSAMVRSLWNILSGIDPYGNVYRLSRLSGDAEYTFRDPRVLRQLMKLIKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZA3</accession>
    <name>H9ZZA3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated protein, Csa1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0066"/>
    <dbReference type="EnsemblBacteria" id="AFH42060">
        <property type="protein sequence ID" value="AFH42060"/>
        <property type="gene ID" value="FFONT_0066"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0066"/>
    <dbReference type="eggNOG" id="arCOG04195">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905009_0_0_2"/>
    <dbReference type="OMA" id="FAYGYCP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009260">
        <property type="entry name" value="CRISPR-ass_Csa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06023">
        <property type="entry name" value="Csa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01896">
        <property type="entry name" value="cas_AF1879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="299" mass="34478" checksum="0CF1C5393F47DE62" modified="2012-06-13" version="1">MMQMLFSLVKDVPKRLYWLRSNDPVPEDLRGWSYHTYPVRPRAYFGLGVSEVAYKYCETFRDLWMRRKEYVRGEVLESSPLYMGKLIHSLMNYAFRDASEIVSRNLGPLESIRRAQELSRKRASELTKSYYRKAMEFYMTMVLSAISTLWIQQSLTNDPLSYISIKTEFVIDGTPVGLSNTLRVDAYHEGGVIIEYKLGNPDPLLTERHSVGLAGYALAIESSLDIPIDYGAIVYISELSRRPSIKVFPVYISSLYRKKFLENRDEAIEVLMRATPPPRSGNCYQYCPFFKACNGGERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZE1</accession>
    <name>H9ZZE1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vird-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0105</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0105"/>
    <dbReference type="EnsemblBacteria" id="AFH42098">
        <property type="protein sequence ID" value="AFH42098"/>
        <property type="gene ID" value="FFONT_0105"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0105"/>
    <dbReference type="eggNOG" id="arCOG04816">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_426201_0_0_2"/>
    <dbReference type="OMA" id="LGYRFTY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019476">
        <property type="entry name" value="T4SS_TraD_DNA-bd"/>
    </dbReference>
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        <location>
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            <end position="588"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="639" mass="71960" checksum="2517D5BC3CF0F048" modified="2012-06-13" version="1"> </sequence>
</entry>
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="AFH42120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="93" mass="10553" checksum="B4D3245583B24F1C" modified="2012-06-13" version="1">MSYAELKSKKFTHKGEETGATEDTFYVTDENQVTYEMSAAVYYIWKVSDGTKSLEEIVKQASEELNIPVNELEEPIAMIITKLLESNLLAEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZH4</accession>
    <name>H9ZZH4_FERFK</name>
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        <submittedName>
            <fullName evidence="2">GCN5-related N-acetyltransferase</fullName>
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        <name evidence="2" type="ordered locus">FFONT_0139</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    <reference evidence="3" key="1">
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="311" mass="35630" checksum="1E94E10D290748C2" modified="2012-06-13" version="1">MENLELEDSFSKKENSMKNVIVRKARISDVDRIFKIYSENIEYLDEESKNWLKSIIKKKSRRARIYVALKRKKLVGFIIFYKKRKEAYIDAFAVDSRYRGLGIGRKLLNCIEQTLELEGVKRIYLSVKNGNNNALGLYLKNGYKVTNIVFILEAGLDNLNGKLGELEGLKLKVDSVKKHNEINSKIKLLDTSIWSNLTWDIDDSIYKISKEEATYITIYSGKRLIGVARAHIDKNKVVIERLALSYYKATDSLITIASAIKTKIALKPKMKIRIPVDSSKASLLKALIAFGFKIINSEYVLCKDFPSIEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZH6</accession>
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        <submittedName>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="227" mass="26122" checksum="014A8560ABC19B1F" modified="2012-06-13" version="1">MKEPTFKKYQNLYYKFIPEGDFWEKMKPKKDKVALVIVDVQKGFLEEAKMIKEKHGHAYLYDRLVQVTIPNIKKLLDFFRENKLPVVHAVIGSYRTDGKDRSPVQSRPGWNYSLQIIGTSSQEEVDELRPLKDEIVVYKTTDSALNGTSLGHILRWMGIEHVVVTGIVTDQCVAGTVRDLADWGFIVYVVEDATAAISQEYHEMELRIINQIYAKVVSTEEIIEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
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    <protein>
        <submittedName>
            <fullName evidence="6">Ethanolamine transporter</fullName>
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    <gene>
        <name evidence="6" type="ordered locus">FFONT_0142</name>
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    <organism evidence="6 7">
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    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH42134">
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        <property type="gene ID" value="FFONT_0142"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="AA/rel_permease1"/>
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    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
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</entry>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Beletsky A.V."/>
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                <person name="Bidzhieva S.Kh."/>
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</entry>
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                <person name="Mardanov A.V."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0213"/>
    <dbReference type="EnsemblBacteria" id="AFH42204">
        <property type="protein sequence ID" value="AFH42204"/>
        <property type="gene ID" value="FFONT_0213"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="EPLYPDC"/>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="287" mass="32887" checksum="1D308E2201276E29" modified="2012-06-13" version="1">MLNLDGISPIIKKPCVVVSIFSGGPDSFCYTLKWIKEGCDLHLLTFNYGQKASREVEVSKKLYEKLKEFAGESIRIEHKILDISFMKDLWNKTQLIDKSKELSSEYETSIVVPIRNVVMLSIASAYAYSLISEDESLNAYVIYGAHSDDASISEKAGGPKYPDCSSECIESLQASFRICHFPKDRRLEIWSPIREGMSKAENIRKCYDIAENIIYETWSCYRDGDFHCGKCESCINRHKAFLKANIPDCTIYGEPPGNREEFIKVEKGYIHKSCKKFYEFSTNYNKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZS2</accession>
    <name>H9ZZS2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase, family S54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0238</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0238"/>
    <dbReference type="EnsemblBacteria" id="AFH42229">
        <property type="protein sequence ID" value="AFH42229"/>
        <property type="gene ID" value="FFONT_0238"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0238"/>
    <dbReference type="eggNOG" id="arCOG01768">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_5_1_2"/>
    <dbReference type="OMA" id="IAYWAHA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="61"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="241" mass="27008" checksum="F75055230B1E104D" modified="2012-06-13" version="1">MLPATNSEKITERPIVNEILIFVNIGIFVVTYFFPWVILPNATSINDIIEFFGITPYYIINGERLWTIFTAMFIHTDIVHVLGNMLFLYIFGDSIEIALGKVKYLLFYFLSGTGAALFYVTSITLVHVPETSSIISQMNNPWLIPAVGASGAISGVLGAYIMLYPSSMVKTLTLWFWAPVVINFPAIIFIVIWFIYQLVLAVLTTFSAVYTGIAFWAHVGGFLTGIAVIPFFARKKFIKAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZS4</accession>
    <name>H9ZZS4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.</text>
            <dbReference type="EC" id="3.1.21.7"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0240"/>
    <dbReference type="EnsemblBacteria" id="AFH42231">
        <property type="protein sequence ID" value="AFH42231"/>
        <property type="gene ID" value="FFONT_0240"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0240"/>
    <dbReference type="eggNOG" id="arCOG00929">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047631_1_1_2"/>
    <dbReference type="OMA" id="RIHFRQA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043737">
        <property type="term" value="F:deoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06559">
        <property type="entry name" value="Endonuclease_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007581">
        <property type="entry name" value="Endonuclease-V"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28511">
        <property type="entry name" value="PTHR28511"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04493">
        <property type="entry name" value="Endonuclease_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="222" mass="24843" checksum="F3778730108B99EB" modified="2012-06-13" version="1">MDMFMKRRFSIKKAKASQLLFKEKAFAQLSLIKTYLSDNINIAAVDCAFTKGKEIIASAVAYRREENDAFFVAIRDKIRIPYIPGFLGFREVPVAAAAVSILRDFVDIDLLLVDGHGIAHPRFSGSATHLGLALDIPTIGVAKSLLVYDKIDEEGNFFYKGILIGKILSYPENARKLYISPGYKIPLEKAFEIVKNLRKKPGLPFPLNYADKISKKVAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZU9</accession>
    <name>H9ZZU9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-2 type transport system, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0266"/>
    <dbReference type="EnsemblBacteria" id="AFH42256">
        <property type="protein sequence ID" value="AFH42256"/>
        <property type="gene ID" value="FFONT_0266"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0266"/>
    <dbReference type="eggNOG" id="arCOG01469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096331_0_0_2"/>
    <dbReference type="OMA" id="AWINGWI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="244" mass="27184" checksum="1E4F1DCE1C4E0FD0" modified="2012-06-13" version="1">MQLRGAISLGWLNGVVAARRNPLWIISNLIPPITFLILMKIYARPEMVEYALIGGFIMIIASNAIGLMGDTVFYKREVKFQDMIVASPMTPVAYMFGLVLSGAFFSIPGITLFLILMAYYHLLSFVAFGVIILSSILSLVALSGLAFTLATFVKEPRFVWPLSGILSFLISVLPPVYYPWILLNKWLAVISMFIPSSSAAALFQKHLGLTSSLPMNELFIWIILIVESLLLLEVAMKLSNWRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZV2</accession>
    <name>H9ZZV2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        </source>
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        <property type="gene ID" value="FFONT_0269"/>
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    <sequence length="80" mass="8914" checksum="26DA40015D97E9D0" modified="2012-06-13" version="1">MGKIRVIVDRRTCIACGVAPTVCSEIFQLGSDNGKNRVIDKYSMKLTDEISEGEIPEELYECAKRAEESCPVVAIHVERI</sequence>
</entry>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        </source>
    </reference>
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            <end position="98"/>
        </location>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    <feature type="domain" description="CBS" evidence="2">
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    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42283.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
    <sequence length="142" mass="15756" checksum="CAECD4612A78366D" modified="2012-06-13" version="1">MDIKRKEYSVKDLMSFNVVTVDPNTSLDEAVRIMLENNIGSVVVVNEKGVLIGILTEKDLITKVIKGKLDLKDLKVKDIMSAPVVYVEPDTPLYEAVALMQSKKIGHLPVVKNGRVVGIIATGDIISIAPEYLELLRIKKKR</sequence>
</entry>
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    <accession>H9ZZY2</accession>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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        </source>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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            <end position="174"/>
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    </evidence>
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                <person name="Mardanov A.V."/>
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                <person name="Ravin N.V."/>
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                <person name="Gumerov V.M."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
    <sequence length="108" mass="12748" checksum="880E94E8B148C684" modified="2012-06-13" version="1">MNIDLEKIKKTVTLNDEEILVLKILQKYGQIDEQILEKETSLDKSKIRKILDLLIIKNVLIPQKRSKSFCDGCPFKNICYTSKNLNDENFIYTLNNNFITKNENNFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A028</accession>
    <name>I0A028_FERFK</name>
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                <person name="Mardanov A.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + CO2 + H2O + L-methionine</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
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            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
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            <name>[4Fe-4S] cluster</name>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="tRNA_wybutosine-synthase"/>
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        <property type="entry name" value="TYW1_archaea"/>
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    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42335.1"/>
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        <source>
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    <sequence length="274" mass="31934" checksum="B684A2503A7FE0F9" modified="2012-06-13" version="1">MSPAAFWCWNACVHCWRLRPSDTGLKWNEVKMPDYNDDVKRVVDRLIEEQRKMLSGYKDHKNVDKKMFEEAMDPKHVAISLTGEPTLYNKLEDLIMEFHRRGMTTFLVTRGVRPDVILNLKEKPSQLYISMEAYNKEMYEWLNQPLVPNAWELTMETLKGLPEYGRPTVLRITLMKGINMDEKAINGFAKIVEIMQPTYIEPKGYMYVGASMLRLSRDNMPTHDEVRKFAEELSKATGYPIRSESKPSRIVLLSKLDKPIRFGKGCPEGWNSEY</sequence>
</entry>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:antiporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
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        <property type="entry name" value="MATE_fam"/>
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        <property type="match status" value="2"/>
    </dbReference>
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            <end position="38"/>
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    </feature>
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        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="450" mass="50405" checksum="0A455B74839F4026" modified="2012-06-13" version="1">MKTIDKEEIFSENIGSTLIKLSIPLIVSDLVQVIYNFVDTFWLSRLGTEALSAPVVSWPPVYFLISFGAGLLSSGIATISQDYGKGDYKSAREYSGVLFLFTLVFSLIVSVIPAIFSYYILKIMNIPEDLIPFANIYLRTILLATPFAYIGITFTTITSALGDVGLTMKINLLSVVINVILDPFMIFGIYPFPKMGVFGSALATLVSEVVVAIYSIFMLFYKYKKLNIGVKDLKFDMKWLKEIFRIGVPLGIHRSSNSLAQTFSISLLSFYGADVIAAYGITTRIIDFVQSITTGYARATAIMVGANLGRKFIDRSKEVVKKSLLDLSLILVFIGVILVLFRDQLIGIFTQDPSVFKYAVDYLFISSITLPFYGWFFISYGVANGSGNTYFFGLLSVLRMWVFRILPMFICIYILTFNVIYIWLVIAVSNIISGITGLMWVNKKTWIVIK</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="45" mass="5350" checksum="E1767E5C387964BD" modified="2012-06-13" version="1">MEWTTFNTGGPEKICEEPKRENNVIQLAFKYKIYPTREDVKKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A079</accession>
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        <submittedName>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="252" mass="28385" checksum="576CC11510D1894E" modified="2012-06-13" version="1">MIGKSMQLPLVSDLMEGNLSEGIYVIAGPPGIGKSVFVKRLIANSIADSYILYVSVDSSIKDMLEFLEKMNISKYKDHIQFLDAFSTTFTGIKQDIQYEKINLESASDSLFTIYSKLSQMDGNKILVIDSITEMLIGTDPDTSISFIKGLKQITESTHTLGVITIHTGPDSLKDILWILEYLSDGYIELAFEPNFEAVGILLRRIRIKKMRNKFHDSNWYPYKIVKDYGLQFMSPQELKAIADVVTGKKSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0A8</accession>
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        <alternativeName>
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        <name evidence="17" type="ordered locus">FFONT_0425</name>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 14">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
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        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
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    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>[4Fe-4S] cluster</name>
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        <text evidence="14 15">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
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    <comment type="subunit">
        <text evidence="4">Heterodimer composed of an alpha and a beta subunit.</text>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
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        <property type="entry name" value="THDP-binding"/>
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        <property type="entry name" value="TPP_enzyme-bd_C"/>
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    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
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        <property type="entry name" value="TPP_enzyme_C"/>
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        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
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    </dbReference>
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        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="582"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="613"/>
            <end position="642"/>
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        <source>
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        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00030514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR006439-50"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFH42415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="645" mass="70371" checksum="12874EA01ED74789" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
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    <name>I0A0B1_FERFK</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="4 5">
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="312"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="422" mass="46754" checksum="8581A3FC741273CD" modified="2012-06-13" version="1">MNKTSNIPKELLDKVESLKDEMVNTLVELIKIPAISPSSGGEGELDKAKKLLEIIKKWKFDDIIEVNAPDPRAKGGIRPNIVAIYKGKNEKDKIWFLTHMDVVPPGELSKWTECKPFEPVVKNGKVYGRGSVDNGQSLVASLYAVKALMDLGIRPSRTVALAFVSDEETGSEYGAQYLLKARPDLFGENDWIVVPDGGNSEGSFIEIAEKGILWLRVKVTGKQVHGSMPDKGLNAHRVAADFVITLDKKLHEKFNKRNDLFDPPRSTFEPTMVRGSAGSVNIIPSDHEITFDCRILPEYTIDEVLNVVNQTKNEIIAKHKKVIEGESLPKIEIEIVNRSDSTKPTDPNSEIVKKLTESIQKLRGITPKTGGIGGGTVAAFFRQKGIPAVVWCTIDEVEHQPNEYASIKNMVEDAKVFLSLMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0C0</accession>
    <name>I0A0C0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RPOL9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0437"/>
    <dbReference type="EnsemblBacteria" id="AFH42427">
        <property type="protein sequence ID" value="AFH42427"/>
        <property type="gene ID" value="FFONT_0437"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0437"/>
    <dbReference type="eggNOG" id="arCOG00580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166550_0_0_2"/>
    <dbReference type="OMA" id="EYDQEEM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="DNA-dir_RNA_pol_M/15kDasu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="PTHR11239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RPOL9" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="87" mass="10011" checksum="3836450A56E3A292" modified="2012-06-13" version="1">MVPVKKDGETVLRCTKCGYEMKAKKKESYVIKEKVKEKDKPKTTSLVSEPSKFGVSDEEQQQRVEDYYEIALELMQEESEGSDEGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0F7</accession>
    <name>I0A0F7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0474"/>
    <dbReference type="EnsemblBacteria" id="AFH42464">
        <property type="protein sequence ID" value="AFH42464"/>
        <property type="gene ID" value="FFONT_0474"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0474"/>
    <dbReference type="eggNOG" id="arCOG05585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_320712_0_0_2"/>
    <dbReference type="OMA" id="GAHYIWG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="857"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="893" mass="93888" checksum="2AD591A9C3D85C0C" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0J4</accession>
    <name>I0A0J4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps17</name>
        <name evidence="4" type="ordered locus">FFONT_0511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0511"/>
    <dbReference type="EnsemblBacteria" id="AFH42501">
        <property type="protein sequence ID" value="AFH42501"/>
        <property type="gene ID" value="FFONT_0511"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0511"/>
    <dbReference type="eggNOG" id="arCOG04096">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_0_3_2"/>
    <dbReference type="OMA" id="DPECPWH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_A">
        <property type="entry name" value="Ribosomal_S17_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_S17_arc-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019978">
        <property type="entry name" value="Ribosomal_S17_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="116" mass="12810" checksum="0205931B8A95142F" modified="2012-06-13" version="1">MGVKKEVKNPGIPGVSIPEKKCNDPNCPFHGTIKVRGMLITGKVVSDKMDGTVVVVHDYLYYDKKYKRYEKRKSKIHAHVSPCLDVKIGDTVIIGETRPISKTVSFVVLGKPTAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0L7</accession>
    <name>I0A0L7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0534"/>
    <dbReference type="EnsemblBacteria" id="AFH42524">
        <property type="protein sequence ID" value="AFH42524"/>
        <property type="gene ID" value="FFONT_0534"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0534"/>
    <dbReference type="eggNOG" id="arCOG02742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_714960_0_0_2"/>
    <dbReference type="OMA" id="EYYETRE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF58" evidence="1">
        <location>
            <begin position="158"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="386" mass="44256" checksum="8EDDF1A789145092" modified="2012-06-13" version="1">MLVASLFQAFLLRREKCEVNIKDVKAGEKFLVYETPKINIKIDKCKNFKEAIFSSFVKVEEIKKARDKVSISAKLLFNSSGEYDIISGNIFQSSIFDVFRLEKSFERELAIKVLPQTLVWIVRGLRLLGLASSGKTSYFEVTYLGEGIALIPNVRSGEYIRNRFFEPGDVPKRIDWKSSMKNLRLIIREYGENPHGSVMLLVDYTCAGLRNCDLLASSILSISQLIYEEGINDIQLYENDSSKVMRFDSPLKLLGYLTGKILEKKIVPVEDMKLHEYVYPLTLQELYEILSRFYKGSLLIDEKGEKLSSSSDTAIFVSNIFHDPSRILDLISRIKRYNAVVITPDSPWKDEVDIEDAYRIFTSYSLAKKKIEKLGVKVISWKGLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0M5</accession>
    <name>I0A0M5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L(+)-tartrate dehydratase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0542"/>
    <dbReference type="EnsemblBacteria" id="AFH42532">
        <property type="protein sequence ID" value="AFH42532"/>
        <property type="gene ID" value="FFONT_0542"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0542"/>
    <dbReference type="eggNOG" id="arCOG04406">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098588_0_0_2"/>
    <dbReference type="OMA" id="IYHCGPL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase_C" evidence="3">
        <location>
            <begin position="7"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="208" mass="22959" checksum="198FBB3F4207666E" modified="2012-06-13" version="1">MSSESKIIIKTPVIDSSQLEELRIGDMFYLSGILVTARDAVHKRFLIDGESLPIDLKDLAILHAGPVMKKVGEKWQCISIGPTTSRRMEYYEDEFIEKTGVKIIIGKGGMGKKTADACSKHKAIYAIFPGGCGVLGASEVEEVIDVKWEDLGMPEALWILKVKEFGPLIVSIDTRGNNLSDAILEESIMNGRVTGEKLEKKLKEMGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0N8</accession>
    <name>I0A0N8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0555"/>
    <dbReference type="EnsemblBacteria" id="AFH42545">
        <property type="protein sequence ID" value="AFH42545"/>
        <property type="gene ID" value="FFONT_0555"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0555"/>
    <dbReference type="eggNOG" id="arCOG02231">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046973_1_0_2"/>
    <dbReference type="OMA" id="SVYSFCM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="474" mass="51732" checksum="0FBD847211071804" modified="2012-06-13" version="1">MNDFDVAIVGAGPAGLFAAIELVKTGSGKLNIALIDKGFKVEKRICPITVKREKSLVSNNDRSINCQACPICHIMYGIGGAGTLSSGIINLRPDVGGDLDKLLGDWMKAEELINYIDKLFMEFGAPEDSLIVPNDKKSRIIERLAAKAGAKYIPTPQRVLGTDVMVKVISNITGFLEKNEVKIMEGTDVKDLKKENGQIKLITDKGEIFAKKVLLAPGRGGARWFHDLAQKIGIDIEPGPLDIGVRVEIPYYITEHITSINHDPKIVMYTKFYDDKVRTFCTNPHGFVLKEYYDDGTVGVNGETYKNLKSKNTNFALLVTLKLTDPYSDVLEFGKSIAKMATKVGMGKPIVQRVGDLEKGRRSTWERIGRSVITPTLKSVTPGDISLILPYRVVSNILEALSRLEEVYPGVSSPQTLLYAPEIKYYGVKAKVTPSLETNIDNIYVAGDGAGLSRGINVAASTGVIAARAILGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0R1</accession>
    <name>I0A0R1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator, Fis family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0578"/>
    <dbReference type="EnsemblBacteria" id="AFH42568">
        <property type="protein sequence ID" value="AFH42568"/>
        <property type="gene ID" value="FFONT_0578"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0578"/>
    <dbReference type="eggNOG" id="arCOG00021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054903_0_0_2"/>
    <dbReference type="OMA" id="GGMGIEP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="300" mass="33733" checksum="9F1059B69C98EA18" modified="2012-06-13" version="1">MIPEELVSKYVTPSIKGLIIHNLVKRGYGQFKVGKLLGISQPMVNKYLSVNESIYIEKLKKVGINEEEVSRLVEVLSETLHDNRPFDYIKLLHSYTASLLERGVLCNFHRKIYPIIPGDCNICLTSHKEKKDILIDEVRTAFELFNSNPNSYLLIPEVGSNIVAFPESGRSYIEAVGFSGKIVNIGSRVIAVGEPMRGGSRHTATVLSKVKNRFNEVCGVIVIRYDRKIIEKMDRLGYKISKVKPHSSMEEFYLYLDELLGELKDPPDVIVDEGGEGIEPVCYIFGKNAIDAVKKALNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0W5</accession>
    <name>I0A0W5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methylase involved in ubiquinone/menaquinone biosynthesis-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0632"/>
    <dbReference type="EnsemblBacteria" id="AFH42622">
        <property type="protein sequence ID" value="AFH42622"/>
        <property type="gene ID" value="FFONT_0632"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0632"/>
    <dbReference type="eggNOG" id="arCOG01773">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1965455_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="127" mass="14129" checksum="45E7A71E0DA4903E" modified="2012-06-13" version="1">MYGGRIDSIIELGFGDGSILSEVAKHVRVRALYGCDINYEALNKASEKGIITVKADLNTDKLSFPDNYFDAVIMEEVIEHLVNPDNALEEAYRILKPDGIFILTTPNLAWWVNRFILLLGSSLIGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0W7</accession>
    <name>I0A0W7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="471" mass="50851" checksum="C4267F327ED0A75B" modified="2012-06-13" version="1">MSNNNNDNLIIEKLFKPKSIAVVGASRNLEKIGGVILSNLVKNKFNGKIYAVNPSAKEILGVPSYPSLLDIPDEVEHIVVAIPAEKVPEIIEEAGKKGVKVATIIASGFKEVGRADLEEKVVNIAKKYGIRILGPNVFGVVYTPMNLNATFGAEHIHKGKIAFLTQSGALGIALMHWTSMEKIGLSSIVSMGNMTDIDAIDLAKFFEKDENTKVIGLYLEGLGTGKGHEFIEVFSEITKKKPVIALKAGRSERGTRAVASHTGSLAGSDAVYDSALKQAGVLRASDVEQLFNWAKMMAFSESFEINGKGFVIITNGGGMGVMATDASEFNGLPLLEVPEELKKEFRKTMPWFGSPNNPVDLTGQSNVQNYIEAIKVALESELVSGITVMYGEVAFLDPVELANGIAKTLKEYNKSRKPVNVVMLGGEKTKMGTEILEENGVPVYPIPEKAISSMAALYKYSKIIGKANLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A175</accession>
    <name>I0A175_FERFK</name>
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        <submittedName>
            <fullName evidence="6">ABC-type iron(III) transport system, permease component</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42732">
        <property type="protein sequence ID" value="AFH42732"/>
        <property type="gene ID" value="FFONT_0744"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0744"/>
    <dbReference type="eggNOG" id="arCOG00163">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="QAFWRVA"/>
    <dbReference type="Proteomes" id="UP000007391">
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="604" mass="66361" checksum="14DD5F7C65377582" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A188</accession>
    <name>I0A188_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0757</name>
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    <organism evidence="2 3">
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFH42745"/>
        <property type="gene ID" value="FFONT_0757"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0757"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="58" mass="6819" checksum="CF5561A2FCC544B8" modified="2012-06-13" version="1">MNAFFQLKYIRMVKEPLQIFSLSRQSFIFSIGSIINKAFAISIFIILIIKAKIYYVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1C6</accession>
    <name>I0A1C6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rad50 zinc hook domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ordered locus">FFONT_0795</name>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0795"/>
    <dbReference type="EnsemblBacteria" id="AFH42783">
        <property type="protein sequence ID" value="AFH42783"/>
        <property type="gene ID" value="FFONT_0795"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0795"/>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013134">
        <property type="entry name" value="Zn_hook_RAD50"/>
    </dbReference>
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        <property type="entry name" value="AAA_23"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04423">
        <property type="entry name" value="Rad50_zn_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51131">
        <property type="entry name" value="ZN_HOOK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc-hook" evidence="6">
        <location>
            <begin position="436"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="230"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="363"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="656"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="481"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="930" mass="107620" checksum="030CD0BBBC46B70C" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1D0</accession>
    <name>I0A1D0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0799"/>
    <dbReference type="EnsemblBacteria" id="AFH42787">
        <property type="protein sequence ID" value="AFH42787"/>
        <property type="gene ID" value="FFONT_0799"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0799"/>
    <dbReference type="eggNOG" id="arCOG00349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_9_1_2"/>
    <dbReference type="OMA" id="DVFEMND"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="78" mass="8032" checksum="DDBE3B1C5F5505D2" modified="2012-06-13" version="1">MAKVKVTIDRNTCIGCGVCANLCPDVFELNPNDGKSSIVEKFRVGGDLGAGEVDESLEECANSAAGSCPVSAIKVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1D5</accession>
    <name>I0A1D5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0804"/>
    <dbReference type="EnsemblBacteria" id="AFH42792">
        <property type="protein sequence ID" value="AFH42792"/>
        <property type="gene ID" value="FFONT_0804"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0804"/>
    <dbReference type="eggNOG" id="arCOG13981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2519609_0_0_2"/>
    <dbReference type="OMA" id="ATFIMYF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="84" mass="9336" checksum="0A2EDE61210B2AAC" modified="2012-06-13" version="1">MDEDAETYIELYGEYVSLKELTIASLISIAFAFLLYYFAPYIAMRSNPSLINALKITLGAIGASIGFLISIPITKVKRVIIEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1G0</accession>
    <name>I0A1G0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor E</fullName>
            <shortName evidence="4">TFE</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">TFIIE subunit alpha homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Transcription initiation factor TFIIE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tfe</name>
        <name evidence="6" type="ordered locus">FFONT_0829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The winged helix domain is involved in binding to DNA in the preinitiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TFE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0829"/>
    <dbReference type="EnsemblBacteria" id="AFH42817">
        <property type="protein sequence ID" value="AFH42817"/>
        <property type="gene ID" value="FFONT_0829"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0829"/>
    <dbReference type="eggNOG" id="arCOG04270">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100097_0_0_2"/>
    <dbReference type="OMA" id="FENDFLC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01909">
        <property type="entry name" value="TFE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016481">
        <property type="entry name" value="TF_E_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="PTHR13097"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
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    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="7"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="180" mass="21396" checksum="339948466CE04848" modified="2012-06-13" version="1">MPENVVPNDPLEEFISKMATNPSLLIFRFLAKENSEATEDTLSEKLGMSKNLVRKLLYKLHDINVVVYRRVRDEETNYYIYYWKINWEGLAATLLERKKEVLKKLKEKAASEEGKVGIYYCKKCGREYTFDEALENDFRCKICNEPLEFTQKGKYEEFLQKYIKKLEEEIKIESERNYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1I4</accession>
    <name>I0A1I4_FERFK</name>
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            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
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    </protein>
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH42841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_0853"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="76"/>
        </location>
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        </ligand>
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        </location>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="407" mass="45951" checksum="04E10F6696FE9494" modified="2012-06-13" version="1">MLKLQNEDFLDEVFKSIKRASIFLDRDKLTPDYVPENLPFREEQIKKIASILAQALRNSRPNNIFTYGLTGTGKTAVVKLVTKKLQERAVELKLPIQTVYVNCRQRDTSYRVLADIIESLGGHVPFTGLSLAELYRRLISKLESLGGRFIVILDEIDFIIKKQGDDLLYKLTRINEELKNSSLSMIGITNDLNFIDNLDPRIRSSLGEEEIVFPPYNALQLKSILEDRAKIAFRTGALDEGVIDLCAALAAREHGDARKALDLLRVAGEIAEREGDEKVRKEHVEKARKELEKDKVYEVVSTLPLHAKLILASIVDLTRRGKDSATTGEIFVEYSKKTSELRLETLTQRRVTDIISELDMMGLVSARVISRGRYGKTKVVKLIANLNTVLNALKDDEILESVVDVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
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    <name>I0A1I7_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Ferredoxin domain containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0856</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42844">
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        <property type="gene ID" value="FFONT_0856"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG04483">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111491_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="entry name" value="DUF2148"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09918">
        <property type="entry name" value="DUF2148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2148" evidence="1">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="114" mass="12472" checksum="663BBE7360339DD5" modified="2012-06-13" version="1">MEELSSYFGSFFSRDTNNVRNSDAIVLIGCKIIDQGLKRSEKWKIDPNTACFLVNLGISLGSAVKMASLLNIDNRIMYSIGVAAIKLGLIDADVAFGIPISAKAKNIYFDRPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1L0</accession>
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        <submittedName>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFH42867"/>
        <property type="gene ID" value="FFONT_0879"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01924">
        <property type="entry name" value="A_A_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="A_A_dipeptidase"/>
    </dbReference>
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        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_M15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026671">
        <property type="entry name" value="AA_dipeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="258" mass="30008" checksum="FBA574DCB8A05CDC" modified="2012-06-13" version="1">MVSQLKKIDTSIIERAIPIPSEEWNWNKIRSIKIIESNEPLVPLSLVPEHILCRPQYYIQGIGNSLPECYSRKGVLLRLLKASSRLPSEYKLVILDAWRPITVQQSLFDTLKERIMKENPLISEEEAIKETLKFVALPSKDPNKPSPHNTGGAIDLTIADENGLFLNMGTDYDDTTEKARTTYFEEKVRRGEKLSEEEEEALKNRRLLYNIMIDAGFTNYFDEWWHYDYGNQNWAWLSGKDNAIYGKAKVKFTWKEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1P2</accession>
    <name>I0A1P2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrate transport ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0911"/>
    <dbReference type="EnsemblBacteria" id="AFH42899">
        <property type="protein sequence ID" value="AFH42899"/>
        <property type="gene ID" value="FFONT_0911"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0911"/>
    <dbReference type="eggNOG" id="arCOG00193">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="THCEKSH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="213" mass="23648" checksum="443A5907CE3EFB44" modified="2012-06-13" version="1">MDELIAVRNLTKSFSDGPVISNISFKLNRGEVLGIMGPNGCGKTTMLRTILGLENKDSGEVKIRGKIGYVPQDNLLLPWLKLRENIVIGLKISGAGEREIEERLSYVSELLSLNDHLDKYPNRVSGGTARKASIARALIIMPDILILDEPYTGLDSSSISILQTLLKNLKKEIRLGIIIVSHQVDELMEISDRIIVLTHRPARIKDVIEANKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1P4</accession>
    <name>I0A1P4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0913"/>
    <dbReference type="EnsemblBacteria" id="AFH42901">
        <property type="protein sequence ID" value="AFH42901"/>
        <property type="gene ID" value="FFONT_0913"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0913"/>
    <dbReference type="eggNOG" id="arCOG01803">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_865015_0_0_2"/>
    <dbReference type="OMA" id="ENILAVW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="326" mass="36310" checksum="D90AB8E29F028EF5" modified="2012-06-13" version="1">MNTKYILIIIVVVAVALGASYAFYREKESSPMIIRAGTLQGGISTLDIMQYYNLSEKYGYELQVYRFDKTTDIINALASGSIDVAVIPSEMAANMLLQNISVKIIAPEMLQNQAILTVKGNISAQELKGKTVATLLSTGTYMMFKAYMKYIYNITVSEQGKGNDTIYAINTLPGSFLDVMRENDIYAIIAWEPFVSEAVVNYNASIIADYQTFWKEANMSGEPVMLIWVASPSASNNKELINSFLKTREDAVNIWNGNENETISALMSIYNLNEKTAEYLYSRVTVLDNNLSQGVIDGIRSSWKLAWIGGYLTSDPSSIGDQVFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1R8</accession>
    <name>I0A1R8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proline--tRNA ligase</fullName>
            <ecNumber evidence="6">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="6">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">proS</name>
        <name evidence="8" type="ordered locus">FFONT_0937</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0937"/>
    <dbReference type="EnsemblBacteria" id="AFH42925">
        <property type="protein sequence ID" value="AFH42925"/>
        <property type="gene ID" value="FFONT_0937"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0937"/>
    <dbReference type="eggNOG" id="arCOG00402">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_4_2_2"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PTHR43382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
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        </source>
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            <dbReference type="EMBL" id="AFH42925.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="482" mass="55887" checksum="4344C9BE6682E872" modified="2012-06-13" version="1">MRYLDDINPEEFSEWFDTVIKEAEIYDYGRYPVKGMGVWMPYGFALRKNIIELIRKEHDSKGHEEILLPLLIPEDLLIKEEEHIRGFRDEVYWVTHGGLDELDVKLALRPTSETSISLMESYWLNSYKQLPKKFYQIVSIFRYETKATRAMIRLREVSTFKEAHTAHSTFEDADRQVREAIEIYSTIFDQLGIPYVISKRPDFDKFAGALYTIAFDTVMPDGKVLQVGTVHHLGQNFSKSLDVKVLQENGENDYVWQTSYGLSDRVIASTISIHGDKRGLILPYIIAPIKVVIIPIYFNDEEKKGVIEYSEEIRNELENCGIRTVIDTRTELTPGKKFYDWELRGVPIRLEIGKREISSKTVVIVTRDELKKKSIAREKICESVRKEGEEIDKRLRERAKKKMEEKISKVEKLELTMEYGERVRGIIEVPWCGSEDCALKIQERTGIRVLGSPIEKPEWIKGKTCPVCGRNAVTSLRLAKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AFH42937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="124" mass="14054" checksum="CC414F60839A4803" modified="2012-06-13" version="1">MVEKKLPLLASGKLGANYELIFKYWEIAKRESPEKEKDVVLSTDDLDYAEKLIREKKTRLKVSEIIDELVAKIINRIDSGIALKAYESVYGIKTDPFSARKEVATVVALWILEALENEGKLVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1W5</accession>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
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            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
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    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0984"/>
    <dbReference type="EnsemblBacteria" id="AFH42972">
        <property type="protein sequence ID" value="AFH42972"/>
        <property type="gene ID" value="FFONT_0984"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="21"/>
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        <source>
            <dbReference type="EMBL" id="AFH42972.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="986" mass="114239" checksum="367A3E045A78A64E" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Z7</accession>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_1016"/>
    </dbReference>
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    <dbReference type="OMA" id="THKLGTW"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17179">
        <property type="entry name" value="Fer4_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="229"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="347" mass="39355" checksum="3F191BDE7034921B" modified="2012-06-13" version="1">MKFYVGGVSALEKLFLYFKSNGLNIYGPKKDRNSIIYGELNDFSQLCLSPEGISSKTPQSIKNIVHPSSQLFLKTKSDYSSYAVYDNESGDKVLFGIRPCDLNSLYILDKMLSEDPYYSHRRETIKGIVVQECTIPGKYCFCSKVGTGPNTESGFDISYAFIGEYLVVFKSGSKLGESVLSKLFLREANEEEVKLYNEKIKNAKDTIEKNFPLDVKDIEGALEKSINDAELWKEISKDCIGCSNCNMVCPTCTCTEFIDDIRMNGNAERKRIWVGCLSPVYGQIAGMHFRKEQYMRYRHFVLHKFLFSKKEIGTKICVGCGRCIAFCPLRLDLRKTLNSVVSIYGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A213</accession>
    <name>I0A213_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1032"/>
    <dbReference type="EnsemblBacteria" id="AFH43020">
        <property type="protein sequence ID" value="AFH43020"/>
        <property type="gene ID" value="FFONT_1032"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1032"/>
    <dbReference type="eggNOG" id="arCOG04238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965071_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046917">
        <property type="term" value="F:triphosphoribosyl-dephospho-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002736">
        <property type="entry name" value="CitG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01874">
        <property type="entry name" value="CitG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="288" mass="33107" checksum="AD8EAEF9397A054C" modified="2012-06-13" version="1">MKKIERKTIDDVKFSISLSMMLEPTGWGIGGNVSRMKDHLDKTLQDYIYIGFLSGDILIDNILRFNSDLGEGFLKSMKSIIEKTGTNTSFGTVFLIFFNAASIILKNKRDLNEIGEGAFSYLISIKPSIYFKSLMLTNSSFLHRFSSSLYPSLTDVFTNYEKWDDKKLIDFLRLNIFDPVSQEASTCFTNSIREAEKLIKEEHCSIPTSEEIDKLFRSFCCKYNDYIVYRKYGLERSESCARSCCEGKSPDELCSMGSLSDLVALTLFFYFYKCKSNNIMRKSNFPQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A225</accession>
    <name>I0A225_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Cysteine desulfurase</fullName>
            <ecNumber evidence="3 5">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_1044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3 5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1044"/>
    <dbReference type="EnsemblBacteria" id="AFH43032">
        <property type="protein sequence ID" value="AFH43032"/>
        <property type="gene ID" value="FFONT_1044"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1044"/>
    <dbReference type="eggNOG" id="arCOG00065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_2"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="25"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH43032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="421" mass="47653" checksum="1EEF094F250EC191" modified="2012-06-13" version="1">MIYDVNSIREDFPILKRKIHGRELVYFDNAATTQRPKQVVEAIAKFYLYYNANVHRGFHTLSQEASQLFEESYEEIAKFINGNMEETILTINTTDAINIVAYGWGLRNLKKGDEIVTTVMEHHSNMLPWRELAELTGAKIKYVDITEDGELNYKDLESKITERTKIVAFTLASNVVGTINDYKKIVNLAHSVEAIVIADGAQYVPHVETDVKKMDVDFLAFSGHKMLGPTGIGILWGKKEILEEMKPFRVGGDTIKDVTLDNVVWHDLPWRFDAGTPHIAGVIGLAEAVRYLKKIGMDGVRAHDIELVKHTIKLMKEIDDIEILGPLDPEKRTGLVAFNIKGLHHHIVAKALDMYGIAVRSGGHCAHPLHYRLNYQGSVRASYYIYNTKEEVDYFVEKLQKIISVKERLATEPVENVCTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A232</accession>
    <name>I0A232_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH43039">
        <property type="protein sequence ID" value="AFH43039"/>
        <property type="gene ID" value="FFONT_1051"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1051"/>
    <dbReference type="HOGENOM" id="CLU_2534514_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="83" mass="9832" checksum="8D432286B476CA35" modified="2012-06-13" version="1">MIIKMGKLRMTMPKNEQDIQKVVDEVMSTHPEMAHEHHHEEEGEELVEYMQAIAHALEHLEEHIVRIEEKLALLEKKINELNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A237</accession>
    <name>I0A237_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron (III) ABC transporter, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1056</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH43044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH43044">
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        <property type="gene ID" value="FFONT_1056"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="229"/>
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    <feature type="binding site" evidence="3">
        <location>
            <begin position="33"/>
            <end position="40"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="250" mass="28271" checksum="91E7A62740886627" modified="2012-06-13" version="1">MRLAFSGTLGYGKAITKRVELEIKEGKLFCVLGPNGAGKTTFLKTLAGIIPPFEGKVSVEDSSKKLYISPDPPYLPSLRIIDVILNFIIGDRKFFLYSISDDNVTKRTIMAEEILNTFGLKYGMDYEYEYLSTGEKSKVMLTGALVSEANLLFLDEPNSHLDLRSRIILYQLLKNESNRRIILISLHDLNESLNFCDSILLIGKDEGIFGPYYSGRSIEIALFEKIYGVSFDVFEKDNKIFLFPKDKTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A264</accession>
    <name>I0A264_FERFK</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    <organism evidence="3 4">
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Beta_Casp"/>
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        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
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        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
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        <property type="entry name" value="Lactamase_B_6"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="19"/>
            <end position="201"/>
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        <location>
            <begin position="235"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="SMART" id="SM00849"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM01027"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="428" mass="47645" checksum="4D4B9DDB109E2AEF" modified="2012-06-13" version="1">MKEREKMQIKILGSGKEVGRAAISVEYNNRSVLLDYGVNFDENDNPVMPLHISPIKLDGVVLSHVHLDHIGAAPLLYSSVKPKAFSTRVTRHLARLMLEDFLKLSGYYLDFEINEVNSLLSSIQDVKAGDFVKLSEFFSLDFYHSGHIPGSLSVKVSTPDGSLIYTADINSIDTKLVESAKIDGAEADVLIIESTYGNANHPERKDVEKRLTESVNEVLEKGGTVLIPVFSVGRGQEIMTILAENDVSPVYIDGMVKQATEIMLENKVFLKNSELLEKAYSEQIFLKGWQDRRKVWKKPCVIVSSSGMLKGGPSRYYLRKIADDEKNAVFLVSFQGKNTPGRSIIERGIYEDGGKPVKARVEWMDFSSHAGKNGLIEIIKSIRNLEKIILVHGEPESQNVLADEIKQQTGIVPVIPNTGEVISFSKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A277</accession>
    <name>I0A277_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA-directed RNA polymerase, subunit M</fullName>
        </submittedName>
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        <name evidence="7" type="ordered locus">FFONT_1096</name>
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    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
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    <dbReference type="EnsemblBacteria" id="AFH43084">
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        <property type="gene ID" value="FFONT_1096"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="TFS"/>
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    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
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        <property type="entry name" value="PTHR11239"/>
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        <property type="match status" value="1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="6">
        <location>
            <begin position="61"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH43084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="104" mass="12331" checksum="062DE55552EB1894" modified="2012-06-13" version="1">MKPKKIDGKDVYVCPKCGYTEEVEPKKNEYKIVNKIKHGEKDKLIIVDENKIPETLPKLKDVVYCPKCGNNEVYYWTMQTRAADEPPTRFYKCTKCGYVWREYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A285</accession>
    <name>I0A285_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L10e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl10e</name>
        <name evidence="6" type="ordered locus">FFONT_1104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1104"/>
    <dbReference type="EnsemblBacteria" id="AFH43092">
        <property type="protein sequence ID" value="AFH43092"/>
        <property type="gene ID" value="FFONT_1104"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1104"/>
    <dbReference type="eggNOG" id="arCOG04113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084051_0_2_2"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00448">
        <property type="entry name" value="Ribosomal_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_L10e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022981">
        <property type="entry name" value="Ribosomal_L10e_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="PTHR11726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L16" evidence="5">
        <location>
            <begin position="14"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="170" mass="19325" checksum="B740744945224A32" modified="2012-06-13" version="1">MPIRPARCYTHFSSPPYTRKEYIPGVPQPKITKFEMGNPKLDADYILSLIVLEDGQIRHNALEAMRVAAHKYLTANVGEGNYYLKVTRYPHHVLRENKMMAFAGADRLQDGMRLSFGKPIGTAVRVYKGYDVLVVKVKKEHLEHAKKALKVCSSKIPFPTMIKIEPAKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A298</accession>
    <name>I0A298_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1117"/>
    <dbReference type="EnsemblBacteria" id="AFH43105">
        <property type="protein sequence ID" value="AFH43105"/>
        <property type="gene ID" value="FFONT_1117"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1117"/>
    <dbReference type="eggNOG" id="arCOG01734">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135561_2_0_2"/>
    <dbReference type="OMA" id="RAIIGEF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="168" mass="19137" checksum="7759282016DE0CFB" modified="2012-06-13" version="1">MFSPQTKALQKAMSLESIYIFSIRPEYAEAIFSGRKKFELRRGKGKDLIKGGLAIVYVSGRVKAISGEFTIGRIIRGPPEKIWRYVRKKNEKGISPESWKFIAGAKTAIAIEVLSPKLYEKPVSLREIREVLPTWTPPMGYSKINKNEPIYQIFLSKLLTSKEVKTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2B6</accession>
    <name>I0A2B6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1135"/>
    <dbReference type="EnsemblBacteria" id="AFH43123">
        <property type="protein sequence ID" value="AFH43123"/>
        <property type="gene ID" value="FFONT_1135"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1135"/>
    <dbReference type="eggNOG" id="arCOG07518">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1840479_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="139" mass="15553" checksum="7AAF9B82C22F56DC" modified="2012-06-13" version="1">MLSASQIQVPSDSYSTKIYAYKPKITLILDWSYESSETIKNVLKAKKTLFMNYLIDIDVDMINLQLIAPSENLNNNYNPPAVFLNGKLLSESRTVSEEEIIDLVLSESISENKDLQIEIPSSIKQNPVFGSSALAYSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2C9</accession>
    <name>I0A2C9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_1148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1148"/>
    <dbReference type="EnsemblBacteria" id="AFH43136">
        <property type="protein sequence ID" value="AFH43136"/>
        <property type="gene ID" value="FFONT_1148"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1148"/>
    <dbReference type="eggNOG" id="arCOG01736">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081251_3_4_2"/>
    <dbReference type="OMA" id="HITLRFL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
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    </dbReference>
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        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="95"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="37"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="184" mass="20681" checksum="14B8D66C9788135E" modified="2012-06-13" version="1">MAIEVNDPNVVSKIINIEEQMLSLKVPMKVVEKENLHITLAFIGEISEDTLQDAIEAIKEIEHTKIKAKLKGIGAFPNSNSPRVVWIGVDDKASISIMELYKKVSSSLVAHKVPFEREKDFTPHLTIARIKGRENIKRLASFINEFSSIEIGEVVFDKLKLKKSTLTPKGPIYDDILSKDLREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2D6</accession>
    <name>I0A2D6_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">FFONT_1155</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH43143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1155"/>
    <dbReference type="EnsemblBacteria" id="AFH43143">
        <property type="protein sequence ID" value="AFH43143"/>
        <property type="gene ID" value="FFONT_1155"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1155"/>
    <dbReference type="eggNOG" id="arCOG01430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3038892_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="54" mass="6149" checksum="245CD051F7C7653E" modified="2012-06-13" version="1">MHKDIPGLLDKKILDGLIEVKFSDAKEMTEKLAKEEKGFLPVIPLVLMCMLHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2E1</accession>
    <name>I0A2E1_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Putative transcriptional regulator consisting of an HTH domain fused to a Zn-ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH43148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43148">
        <property type="protein sequence ID" value="AFH43148"/>
        <property type="gene ID" value="FFONT_1160"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1160"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162441_0_0_2"/>
    <dbReference type="OMA" id="CLACGFT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038767">
        <property type="entry name" value="Transcriptional_reg_pdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40663">
        <property type="entry name" value="PTHR40663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="119" mass="13658" checksum="B3AA798CF39BCBC3" modified="2012-06-13" version="1">MSGEENFLTTREKIYLILKNSPIPLTVEDIINMLGYSVREKRKVEEDIEHLALSLKSRSNGKERIAILPARCLNCGYTFKDNRKAKRPSKCPKCKSFRIEGPWFYITESSSSMKGSILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2E9</accession>
    <name>I0A2E9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA(Met) cytidine acetyltransferase TmcA</fullName>
            <ecNumber evidence="10">2.3.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tmcA</name>
        <name evidence="15" type="ordered locus">FFONT_1168</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>acetyl-CoA + ATP + cytidine(34) in elongator tRNA(Met) + H2O = ADP + CoA + H(+) + N(4)-acetylcytidine(34) in elongator tRNA(Met) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:43788"/>
            <dbReference type="Rhea" id="RHEA-COMP:10693"/>
            <dbReference type="Rhea" id="RHEA-COMP:10694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TmcA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.193" evidence="10"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1168"/>
    <dbReference type="EnsemblBacteria" id="AFH43156">
        <property type="protein sequence ID" value="AFH43156"/>
        <property type="gene ID" value="FFONT_1168"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1168"/>
    <dbReference type="eggNOG" id="arCOG01951">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004652_1_0_2"/>
    <dbReference type="OMA" id="NEPDDLG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01886">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="Helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024914">
        <property type="entry name" value="tRNA_acetyltr_TmcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="PTHR10925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="DUF1726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="Helicase_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0819">tRNA processing</keyword>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2G2</accession>
    <name>I0A2G2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1181"/>
    <dbReference type="EnsemblBacteria" id="AFH43169">
        <property type="protein sequence ID" value="AFH43169"/>
        <property type="gene ID" value="FFONT_1181"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1181"/>
    <dbReference type="eggNOG" id="arCOG04349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1363701_0_0_2"/>
    <dbReference type="OMA" id="HIEGWRS"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009324">
        <property type="entry name" value="DUF981"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06168">
        <property type="entry name" value="DUF981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="199" mass="21633" checksum="EC0A482BF82D0A4E" modified="2012-06-13" version="1">MAITYTDPLTAQLFGITGSTILVAYAMLRMAMGQDIKTVLKGLYAPLLAMGVYVFFSGLYGYFIWPLPGSYDILFYDMYAVLGVGLIAIALCIKHDTKLEYIGFLALIYGVITIFYGYSGYSLGMTKEPAGMFALYALVGLSSIVFYFVSFGIDSGKVNKPLLYIEALLLILGGLAAAYIAGSAVPSHLKMFGQYVPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2I3</accession>
    <name>I0A2I3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="7">Glu-ADT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gatA</name>
        <name evidence="9" type="ordered locus">FFONT_1202</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1202"/>
    <dbReference type="EnsemblBacteria" id="AFH43190">
        <property type="protein sequence ID" value="AFH43190"/>
        <property type="gene ID" value="FFONT_1202"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1202"/>
    <dbReference type="eggNOG" id="arCOG01717">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_2"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="54"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH43190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="480" mass="53167" checksum="D1BDFE68098620D9" modified="2012-06-13" version="1">MTFTKKETKVIEQVQMIKEGTLDPEKPFEDAVEQAIKNDPKYNIFITLTSNEDKSIFKKGKLSGIPIAVKDNISTKGIRTTCASKILEDYVPGYSATVVERIEAEGGIIFGKTNMDEFAMGALGTTSAFGPTLNNLNIELSPGGSSSGSAVAVSSGTVKLALGSDTGGSIRLPAAWTGIYGFKPTYGFVSRYGLISYADSMDQIGPLATNISDLILLFSIISGSDERDPTSQFPGINKEKMLKLAYSEADVDILKKLKLIVIKNLIEHPQADEGLINEFWKDLKMLESYGASIELIDEPLILKIPQIYYIIAFSEASSNLARFDGLRYGKRISNVEKNDYDSFYMENRTLFGWEVKRRILLGTFILSKGYYETYYVKALKARTYLRKRIDRILNEETKFIVTPGSLIRPLPLKYDARDLSKLNAVDAPLMLANLIGSPAIVIPTGFSQSSPKSLQLIGRVWSDYTLLSIAKAIELVMKHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2I4</accession>
    <name>I0A2I4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="8">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="8">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gatB</name>
        <name evidence="10" type="ordered locus">FFONT_1203</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer of A, B and C subunits.</text>
    </comment>
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        <text evidence="2 8">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
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        <property type="entry name" value="Asn/Gln_amidotransferase"/>
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        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
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        <property type="entry name" value="GatB_Yqey_C_2"/>
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        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="GatB_Yqey"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="316"/>
            <end position="463"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016923"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH43191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="474" mass="53981" checksum="031D20B9D88DD1D9" modified="2012-06-13" version="1">MTSLKTKLFCGCSSDYRNSPPNTNVCPVCLGLPGSLPMINKKAVEKAIQVAIALNMEISKTLSWTRKHYFYPDLPKNYQITQYDGKGVSTIAKNGYVSYTVNGNSYVARIRRINIEEDPGKILYPSGSMITSDYILIDYNRSGIALLEIVTEPDFKTHQQVSSFLKKLRSILEHLGIADFSLEGSMRVDVNISIGGGKRVELKNISSIAEIENAIVYEITRQRTLLNLGREVEMETRHWDQERKVTFATRAKETEEDYRYFPDPNLPSIEISEELVKKIRESLPELPDKRKERFIKDYKLSEYIASVLVSDKKLSDYFEEVMKSTSIDTQKAASFIVNDVLGWIPSGDTNELNKYIPPQKIAELLEMLREGKITIKMAKELIPELINGKSLKGAVEEKGWFEVIYSEEEILKVIESIMNEYPEAVKDSIKDKKAVQFLVGKVLEATNKRADPKKVYDLICKKIEKISSKLQEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2J0</accession>
    <name>I0A2J0_FERFK</name>
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        <submittedName>
            <fullName evidence="2">GTP-binding protein, HSR1-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000007391">
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="47"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="270" mass="30424" checksum="D1CEAECD681833E2" modified="2012-06-13" version="1">MKDSMKFLRKEKMLEMIRESDFVLETVDARNSLGTRSIKLEKLAFQLNKQFAILLNKIDIVPAEVVAECIKYFKDKGIIVIPISAEKNIGRGEVVNFLLEIKEKLGKEKIVGMIAGVPKTGKSSVINMLKKKDSANISPLPGKPGYTKSTSIYKISSGIYIYDTPGVFPDARDYIEKTIRSSPPEKLKDPVSIAVELIQKASNISKNALSKIYKIEWSGDPYSFLEALAKKRGWIERKSKEPIIDEAARTIIIDYLKGKLKIYKKCMQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2J2</accession>
    <name>I0A2J2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1211"/>
    <dbReference type="EnsemblBacteria" id="AFH43199">
        <property type="protein sequence ID" value="AFH43199"/>
        <property type="gene ID" value="FFONT_1211"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1211"/>
    <dbReference type="eggNOG" id="arCOG01580">
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    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736935_0_0_2"/>
    <dbReference type="OMA" id="YIQYYIP"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="375" mass="43816" checksum="0FA70FB697AB441F" modified="2012-06-13" version="1">MRVIDEAFFLKRYDVNLLIEQIMRTDPPIRISKIAEDLNEPISQIRRKISKLYNLGYGFKGDFDLRRIGLSTLVLGFNEPIDDVIKKLPRNFSQYLPFLRRWQGETFSPKHLSIALMYIPYNYDVLANAYGILEKANISLEIKPFIADISIIGKPRTKYFGLPDYLTNWELLYNDLKKEEDEENIKEILKIDPINLDLIDVLILASYQKDAFTPVSKIASDLKLSISKINRHLKTHIEKRKIFNGCSIKQLISKLDIQNRIMMLLIGKNEDLSTLLKFISIVKNSPEFYSALVDSNNNMYMMLFSIMFSEIDLFSKFIKNVKEYLGEYNIFILNPSTIKSYTIPFLAYNREIKNWDFKISVIDIMKEKLEALLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2J3</accession>
    <name>I0A2J3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1212"/>
    <dbReference type="EnsemblBacteria" id="AFH43200">
        <property type="protein sequence ID" value="AFH43200"/>
        <property type="gene ID" value="FFONT_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1212"/>
    <dbReference type="eggNOG" id="arCOG07493">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176733_0_0_2"/>
    <dbReference type="OMA" id="MMYEIEM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="87" mass="9507" checksum="533DEE0B52BA31EC" modified="2012-06-13" version="1">MSEGIADGTIKKLLKTLDEKGTANPGEIASITGLPRYYVLAAFQILKELGYVELIYSKGSHKVYKLSEKGSSILEDNIVTKKETAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2M6</accession>
    <name>I0A2M6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA-free ribonuclease P</fullName>
            <shortName evidence="5">RNA-free RNase P</shortName>
            <ecNumber evidence="5">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protein-only RNase P</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1245</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HARP family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1245"/>
    <dbReference type="EnsemblBacteria" id="AFH43233">
        <property type="protein sequence ID" value="AFH43233"/>
        <property type="gene ID" value="FFONT_1245"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1245"/>
    <dbReference type="eggNOG" id="arCOG00720">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109672_0_0_2"/>
    <dbReference type="OMA" id="YIIKKPP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01078">
        <property type="entry name" value="RNA_free_RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014856">
        <property type="entry name" value="RNA_free_RNase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41173">
        <property type="entry name" value="PTHR41173"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08745">
        <property type="entry name" value="PIN_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03875">
        <property type="entry name" value="RNA_lig_partner"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="186" mass="21657" checksum="D3B47A355DA8874F" modified="2012-06-13" version="1">MNDVIIKLTQLISKLKLSLGVSFFVTNSIAKEMKNYMLANGVEESTINEFFMWVTVKMPEKLSIKIPAVIFSEYLKEMRMREIKALKISEDFIKKAYDLNYDEKNISELIHDLREKFREAMRKGIIDSPEDFDAVLLSYELKGVLVTNDEGMRKVSEIMGVITIDPLAFLENLRRLMIYLNNEEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2N0</accession>
    <name>I0A2N0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1249"/>
    <dbReference type="EnsemblBacteria" id="AFH43237">
        <property type="protein sequence ID" value="AFH43237"/>
        <property type="gene ID" value="FFONT_1249"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1249"/>
    <dbReference type="eggNOG" id="arCOG04874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040452_3_1_2"/>
    <dbReference type="OMA" id="TNTEPAM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="PTHR11091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="SSF89733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="382" mass="41658" checksum="1D4EFC177EC08EB4" modified="2012-06-13" version="1">MNNNSYYELYEKETPKSSGEYVRIKEEELRALVENIFENNGLSKEHSKIVTDVLVSADLMGISSHGVQRVNRYIMGLKKCCVNPRPEIKVVREIGATAVIDADAGLGHIAGLKAMDLAIEKAKTYGTSLVLVKNSQHFGIAGYYALKAIEKKLIGVAMTNSESLVSYVNTVGKTLGTNPIAIAIPKASLPPILFDAATSIIPVGKVEIYAKEEKELPHGWVLGDDGKVISKDSKKALEMIKNNRASLLPLGGIGEEFGGHKGSGLAFIIDIITGVLSGAAWGIHVGYTVGEKPANVGHAFAAVNIESFMELAEFEKRLEKYIEEIKSLRKIPNADSIWIPGEKAWYTMQTRKKIGIPLHKNVCNELNKIALDSGINERLNCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2P3</accession>
    <name>I0A2P3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein L20e</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">50S ribosomal protein LX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl18a</name>
        <name evidence="3" type="synonym">rpl20e</name>
        <name evidence="3" type="synonym">rplX</name>
        <name evidence="5" type="ordered locus">FFONT_1262</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Binds 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1262"/>
    <dbReference type="EnsemblBacteria" id="AFH43250">
        <property type="protein sequence ID" value="AFH43250"/>
        <property type="gene ID" value="FFONT_1262"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1262"/>
    <dbReference type="eggNOG" id="arCOG04175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177460_0_0_2"/>
    <dbReference type="OMA" id="WQKFTKE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_L18Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="50S_L18Ae/Ribosomal_L18a/L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_L18a//L18Ae/LX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18A" evidence="4">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="86" mass="10094" checksum="A218AE28966119B9" modified="2012-06-13" version="1">MTQVKVYRISGEMLISHDHFPKWQKFNLELTGTSEKDAINKTYSLLGSKHKLRRFHIKINKVEEVANKEAVSKNIQDLLAIDRWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2P8</accession>
    <name>I0A2P8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA small subunit methyltransferase Nep1</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">16S rRNA (pseudouridine-N1-)-methyltransferase Nep1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nep1</name>
        <name evidence="6" type="ordered locus">FFONT_1267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a pseudouridine in 16S/18S rRNA + S-adenosyl-L-methionine = an N(1)-methylpseudouridine in 16S/18S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:46696"/>
            <dbReference type="Rhea" id="RHEA-COMP:11633"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1267"/>
    <dbReference type="EnsemblBacteria" id="AFH43255">
        <property type="protein sequence ID" value="AFH43255"/>
        <property type="gene ID" value="FFONT_1267"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1267"/>
    <dbReference type="eggNOG" id="arCOG04122">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055846_1_3_2"/>
    <dbReference type="OMA" id="VYVHTRN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00554">
        <property type="entry name" value="NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023503">
        <property type="entry name" value="Ribosome_NEP1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="PTHR12636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="218"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes Arg-xx" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate rRNA" evidence="5">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="240" mass="28242" checksum="12CE4014CF614FB0" modified="2012-06-13" version="1">MEASSIINKHEEKKFGGPLYIIGLVESSLEPLPKELVNSKKAVILSRRFNIEPKYLILDKSLFYEEMKVLKEKEKRGRPDIIHQFLLATQYSYLNLKGKLKVFIHTINNDIIEVNPITRIPKNYFQFVSLIQNLYKYKKVPRSGEALLILRKNVKLSEYLKEKNIEKPILLHEKAEKVEYNELEKFYFPPCSFLIGGFPHGDFSKDTKMVAWRSISLKKDFIMDAWMVADRIICHLEKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2S0</accession>
    <name>I0A2S0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Component HyfC of membrane-bound [Ni,Fe]-hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1289"/>
    <dbReference type="EnsemblBacteria" id="AFH43277">
        <property type="protein sequence ID" value="AFH43277"/>
        <property type="gene ID" value="FFONT_1289"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1289"/>
    <dbReference type="eggNOG" id="arCOG01545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_2_1_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="310" mass="34814" checksum="BC205DCD83B002D1" modified="2012-06-13" version="1">MWEIIIVSLLQITIVLFMSLFLEGVRRKLIARLHSRIGPPISQPFRDLVKLWRKREEIKPECSSWIFEKAPIIALAVLLTLSIMIPIISSIGFSLRDIILIIYSLIIFRFILSLAAFDASSPYGIPSAWRETYLGILGEVALILPVLCLVVTTGTTDLGKISYYVESNLQLLSYPSFYLAAIAGFIALLLETGVQPFDVAEAEQELQEGISVEYSGKTLALFKLDQMLKRVVIPSLFLSLFVPWGISSTFSLAGLLVGTLSFMAKIFIIHMIFLTLSVSNARIRFVEMPQYFEVSIFLSIIALVLAIWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2T0</accession>
    <name>I0A2T0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L40e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl40e</name>
        <name evidence="5" type="ordered locus">FFONT_1299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="3"/>
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        <source>
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        <source>
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    <sequence length="56" mass="6308" checksum="922EE1EBB80E5C4B" modified="2012-06-13" version="1">MPIKDPELVEIVTKRVLDKMICRNCGAINPPNATKCRRCGSKNLRPKKKKLGMKKG</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <sequence length="306" mass="34441" checksum="EB8D2D4B33F4B9A5" modified="2012-06-13" version="1">MEKRYNLMKIAIAHMTLKLLSKKLNFERAKKVVHEAKQKGAKVVILPSMINLGPAISFTSPAQLKSILKNHAERIPSGGTAYFLSTLAVQNSIFIISGPILERAGPKVFLTSLAISPTGNIVGKYRKIVLSHSDISIGLSSGKSLEVVDMKEKYGIMAEWDSYHPEIARGLTILGSTVLINFPRIEPVFDKKLKKILETRSIENNVPIMSIGGIIKSQDQFLAEFPSLIYDPYEGLLEEITLESKKEEKTMKVSDEDKVVLLELQNYTQKPQLQEQKYLMELFTTVYKDLKKKMEGQEEEATKHSE</sequence>
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    <accession>I0A2U0</accession>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <location>
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        <source>
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    <sequence length="111" mass="12985" checksum="AA4B9F659098C274" modified="2012-06-13" version="1">MKRISESIKIITDFEKDVEELKSTYEKKFSNLIEVAERNAKMLNEVANAIVISAKKEIDEKLKNESKEVEEEYNKKLKEELAKIEEAKERKFKLAVEEALKSFLGKFDERA</sequence>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <source>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="345" mass="39451" checksum="1A0CD7FF43B7E1D2" modified="2012-06-13" version="1">MRELDYSYLTPKLYYWKSKLLNFNSYKSIIETNELEKIISILEQSGIKISGEKSEINVDMIATQIEKFTLSMIEEIIKIAPEETSSLVGSFYNWLNMSALLSVVKIYQNKKNISYAGFILSDETFSKLKKGIDSGSVTLNEDPNSIALLMKYFFGYEIVAELGKYKQLAEQSSCFSLYQILGTMFYAKKIKSAFSEIDTFNYMMVRELLGAYMDMKAVEEFINAHKMCNDKKSIEHIALEYNGFFINGKDISNSLISGSYESSFELLASKLNIKSEKDEKKDVSFNIKRKIRNLAEHQFGKYPFSPALSLGYVLLLLIQRDNLMSILIGKSSNISEEIILENLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2U4</accession>
    <name>I0A2U4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1313"/>
    <dbReference type="EnsemblBacteria" id="AFH43301">
        <property type="protein sequence ID" value="AFH43301"/>
        <property type="gene ID" value="FFONT_1313"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1313"/>
    <dbReference type="HOGENOM" id="CLU_599370_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="456" mass="52453" checksum="950AB84942BE3D20" modified="2012-06-13" version="1">MSEELSNKSIICKSIGYLNICENDVIEYKKEELVLSDVLRKIEECIDRNRCSKGVLLAEDFMPIRKVDKWKYLEKAEESLENVISSGKEKLVMKGKINLSEILKSSKYSKIKNFEPVSIPFGIILGVRYKNSVLIPSESFSDFRQSDQRAVQSFFEIRNYFPLLSYAAFSLLKVYRKLLYVIDLPVTIKGNRCPEKGFKLQCYSYSGSARCIFDPNIICPLRVLYRRPNRELYGGVFYWLNTLRMIIEDKEVRSSTKPIDTIVTSFLTYYLYGIALSLSESLFSLIGKKEYIDRGSYSFSEIESGITQLKGMTNNYKLKEFMDLSMKELREIKNSSNPYEMRTRSIISLDNLMLKTKILRKTIVNDSIYSSCHPAELHAGIIEGYINTYFPLLRGSISKIVSEKISMLLRINGCIEPSDLSSILESNLSSVLLNMLTEKNLLSKKKGIEGYVYFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2X1</accession>
    <name>I0A2X1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L37Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Ribosomal protein L43e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl37ae</name>
        <name evidence="3" type="ordered locus">FFONT_1340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1340"/>
    <dbReference type="EnsemblBacteria" id="AFH43328">
        <property type="protein sequence ID" value="AFH43328"/>
        <property type="gene ID" value="FFONT_1340"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1340"/>
    <dbReference type="eggNOG" id="arCOG04208">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141199_2_0_2"/>
    <dbReference type="OMA" id="ISTGIWQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_L37Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_L37ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="86" mass="9588" checksum="DEAC8DC8CFD6D892" modified="2012-06-13" version="1">MGRTKIVGIAGKFGARYGSTLRKQYKEIMEKRYAPHVCPFCGMSGKVTRISIGLWKCEKCGNVWAGGAYVPRTGLNKMFPKSINTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2X4</accession>
    <name>I0A2X4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1343"/>
    <dbReference type="EnsemblBacteria" id="AFH43331">
        <property type="protein sequence ID" value="AFH43331"/>
        <property type="gene ID" value="FFONT_1343"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1343"/>
    <dbReference type="HOGENOM" id="CLU_3093951_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="51" mass="5851" checksum="73B68C5EC3A0E690" modified="2012-06-13" version="1">MEYGLVLRQNNRVHSMVKKESLIALAFIKMKDPIANRCRNIPAILRKGGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A310</accession>
    <name>I0A310_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1379"/>
    <dbReference type="EnsemblBacteria" id="AFH43367">
        <property type="protein sequence ID" value="AFH43367"/>
        <property type="gene ID" value="FFONT_1379"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1379"/>
    <dbReference type="eggNOG" id="arCOG01641">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155660_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="35"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="98" mass="11609" checksum="D82FB786324BF784" modified="2012-06-13" version="1">MTKYRDHKEVYTRDYSRWSVYPKIPKPEEYQAQEKLRPGSEITIEIRDIDEKGRGVGYYNRTVIRVNGGGTVGDKVRVKITERRDNEAYADIVEWLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ56</accession>
    <name>H9ZZ56_FERFK</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">FFONT_0017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42013">
        <property type="protein sequence ID" value="AFH42013"/>
        <property type="gene ID" value="FFONT_0017"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0017"/>
    <dbReference type="HOGENOM" id="CLU_3112894_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="50" mass="5566" checksum="13EE23C8B609F7FA" modified="2012-06-13" version="1">MKVGSTASKYLPAHRISQIELKDVNIASSAATLNVNLSDRIERKRQKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ60</accession>
    <name>H9ZZ60_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0021"/>
    <dbReference type="EnsemblBacteria" id="AFH42017">
        <property type="protein sequence ID" value="AFH42017"/>
        <property type="gene ID" value="FFONT_0021"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0021"/>
    <dbReference type="eggNOG" id="arCOG07237">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_623496_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="439" mass="49646" checksum="2297BE2452F636DD" modified="2012-06-13" version="1">MDLIIPYSPSNQVLIGTLGYELLASDNIERVIVLSENDAGSQAEALRSIGKKLGISVEIKNLGTELHSWSSFSMTPDSVLDITPGRKIYASLLLQSCMKREGCRARYLYLEDEKKYGYNYFGYMPMWAFKFIEFHPELHQADLSVRRLEKVLHAEGIEEKEASVIPETFQSIINLHSYSGDEEFSIEACGGRAEFRFGDKGLFLKDFSFLGKGDEEAFDEALKSFLEIENRDEAAEKAKKCIDEGGVIALDTNVLIQGRMFNFLRSHSKNVEILKPVWSEIIPYALEEKISSVGRRRLAALSRAAALNNSVPAMRDYRRGDQEIINSLKNMKNEKMKVCFMSSDRRLSAIVSTVLGDDTIFLESPELREESRTCAEEVAGFMMNLAFYCNEGKLRIGREEYMFKLGKISNKTLQMPELRVSSESMSVLKAIDLLVRATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ65</accession>
    <name>H9ZZ65_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Probable cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cobD</name>
        <name evidence="13" type="ordered locus">FFONT_0026</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 12">Cell membrane</location>
            <topology evidence="3 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the CobD/CbiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0026"/>
    <dbReference type="EnsemblBacteria" id="AFH42022">
        <property type="protein sequence ID" value="AFH42022"/>
        <property type="gene ID" value="FFONT_0026"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0026"/>
    <dbReference type="eggNOG" id="arCOG04274">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054212_0_2_2"/>
    <dbReference type="OMA" id="ARWPISA"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFH42022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="319" mass="35903" checksum="99EC739A293C6F42" modified="2012-06-13" version="1">MDLSWLYPPGFSYFSIILLSALLLDWMYPKHEGFLYYMHPVHTSYALALFLHRRLPKSKAAGVAIWICSVGIHLVAYGLAMFILRPVSQLVWMILSIYIMKVSISQRLLIDYVREASDCLKRGDIQCARESASNIVRRDLSRLGEGYIASAGIESLFESMVDGFISPLFFYLLLGPLGALLQRLANTMDSALGYKDDEFREKGWASAKMDTILNFIPARIGSLITVLLCPCVGGKVKEAWAAFRKYRNCTESINAGNPMSAASGCLRIKLEKHMHYTIGKEFPLPSYHDLERALRLALCESLAFTATLLALSLFLYILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ66</accession>
    <name>H9ZZ66_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="primary">cobS</name>
        <name evidence="20" type="ordered locus">FFONT_0027</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="21" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
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    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_0027"/>
    </dbReference>
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    <dbReference type="OMA" id="YIAIHIA"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
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        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
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    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="108"/>
            <end position="126"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
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            <end position="220"/>
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    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="232"/>
            <end position="255"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="AFH42023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
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        </source>
    </evidence>
    <sequence length="256" mass="27817" checksum="D19D529ADC67D5C0" modified="2012-06-13" version="1">MKDFFSLLSFLTPIPVPRKYREGGLSFGSVYLLPIIGLLRGGIAIIPAAVLLSLKIKLVPLIAFSIVALHFIMQGFLHADGFIDFTEALLAGRFGVDAKKVLKDKYRGSYAIASFSVFTLWLYSSLSSFQEPGYALILFPISAEVWSPSSMILTSLLSGEPPEGMGREFKRSSSPSSLAASLLISFPFTLMLSFSLKLSLIITALSLSSLLLSSLLSYYMGKKALGYANGDVLGFSNELCYALLLTVYAAGAYLWI</sequence>
</entry>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="66" mass="7797" checksum="A29787190A283608" modified="2012-06-13" version="1">MNLSERIESQNPSIFLSDLKKLNGNRNFQTFLLNLRKELSVHKKLKYSMDPMDVAPMVYQVYDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZE7</accession>
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    <reference evidence="2" key="1">
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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    </reference>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZI1</accession>
    <name>H9ZZI1_FERFK</name>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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</entry>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
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</entry>
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                <person name="Ravin N.V."/>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    <sequence length="563" mass="63196" checksum="9CDCDCD70F04DC98" modified="2012-06-13" version="1"> </sequence>
</entry>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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            <end position="206"/>
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    <feature type="transmembrane region" description="Helical" evidence="5">
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            <end position="325"/>
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            <begin position="346"/>
            <end position="368"/>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="369" mass="40496" checksum="0483FFC99FD9DFD6" modified="2012-06-13" version="1">MNDVVLTVVAIVTYWVIALAIGYALRKKFKGLEVSPFFIIFKKPSALSFLDKYEKNKFLRGLIYASVILTFISLFMFYYYMIEAVALRFSGYSSGGLVPIIPGITIKGTAIIYILISIGIAALIHELSHAFASRVAHIPVKNVGFILAVFIPAAFVEPDEEAFKKASFKDKIKILSAGPSSNLIIAFIFLILILLMTVNAVGATVVSVESGSPAQIYGIKPGYTILEINGTKIGSPYDIGPIIENYTNSGVWFNITYRSPSSENLSWLLVYKPSNVSKIGITIEQAKGIQSLPDSVYFPMLEFFTFMYVINFSLAIINAAPIFITDGGRIISEIISLKIPGNKGKALNFFIQTFTLLLVLSAITFTPIA</sequence>
</entry>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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            <dbReference type="Pfam" id="PF07969"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="525" mass="59870" checksum="AFA3E23EA97A0B32" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZK5</accession>
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        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
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    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccales</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="258" mass="28112" checksum="A841341A183C4B4B" modified="2012-06-13" version="1">MCERLKDRVVVITGAARGIGYATAMLAAKEGAKVAVCDVLEDEGKKAAEEIKRTTGNQNVKFYRLDVTNEDEVKRTFEQISKDLGDVYGLVNNAGIAGVSKPTHEITLEEWNKVINVNLNGVFLCTKHAVPYMIKNNRGSIVNLSSIYGIVGAPDVPPYHASKGAVRIMTKVDALFYAKYNIRVNSVHPGFIDTPMVRGYAEGTGNRDAVYEALKKLHPLGRLGRPEEIASVIVFLLSDESSFMTGSEVVVDGGYTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZN4</accession>
    <name>H9ZZN4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Arginine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccales</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0200"/>
    <dbReference type="EnsemblBacteria" id="AFH42191">
        <property type="protein sequence ID" value="AFH42191"/>
        <property type="gene ID" value="FFONT_0200"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0200"/>
    <dbReference type="eggNOG" id="arCOG04756">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_935739_0_0_2"/>
    <dbReference type="OMA" id="RLPIVMI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="302" mass="34472" checksum="1471DCBC1FE3DA03" modified="2012-06-13" version="1">MAFDLVPVLESIALLFAIMFAGFFYKRLFINYNWYPATAKILFNIVYWVLTPLTFINNFSESGIMSVLIFPFVAITTFVLIAGVIICKMSFKDKETKYVVLINSVNQNNLFIGYPVLYSAFRNATMSLYFGLISFIYAILIPDIIGSGKVLSKRIILNPVILGFFMGNVIHYATPYIASNIPILLFWAPKALVYLSIFVMGMQLTFGTDVFRGSFRKAFYVMAFMRFVLNPIVYLPYIYIFHISQLYRYETILLGIMPPATLNTIMALKYNWHPNFTASSTLILTIISLILATILIMLFGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZN5</accession>
    <name>H9ZZN5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Agmatinase (Agmatine ureohydrolase) (SpeB-1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="297" mass="33635" checksum="753CE33274395BE2" modified="2012-06-13" version="1">MWKLRALKKFPFGGLYKNKEETKISLIGAPLDLTNSHAPGTYLAPEAIRRIAESLEWYSLLYEGDFSENGIYDEGDLVLFPGKVRENIDLISESLLDIKEEKRIPFMLGGEHTVTLASSKLLDEDTLLVVFDAHFDLRDEYLNSNITHATVMRRIVDNFEPKNLLFIGTRAVSQEELDFVKKNQIEYITSRRIWLYGISEFARNIERKLEKFGKIYVSIDIDAVDPGYAPGVSTPEPLGIDPHMFFGLLDPLVNEKLIGLDIVEVNPIRDAGEATSALAAKIVIESAIKLNKIYNKR</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH42225">
        <property type="protein sequence ID" value="AFH42225"/>
        <property type="gene ID" value="FFONT_0234"/>
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            <dbReference type="EMBL" id="AFH42225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="47" mass="5567" checksum="53D4821A701CE7C5" modified="2012-06-13" version="1">MNPEKRFTSRLENSKHRASLSLMLFMESFFSKDHSYQLNEEVMLEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZW0</accession>
    <name>H9ZZW0_FERFK</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0277</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccus</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Skryabin K.G."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <location>
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            <end position="39"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="193" mass="22506" checksum="713D1669041E34B4" modified="2012-06-13" version="1">MNPLAEVIKAKEIDTWLHKEKSFYLKIFLLFFTVFGAFYPNRIDVMIFDSILLASLFISGKLYDLFISLIFLYSMTILPIELISFLSGTNVSYLIFLAIYTLSTVLSFFLFTSTTKNETIEEKIKIKVLIYSFNFIYYAIYELQEIINSFKVRGYQVSYLKPWKAVPILVSYVYLLSQRLDMIEISVEARGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0300"/>
    <dbReference type="EnsemblBacteria" id="AFH42290">
        <property type="protein sequence ID" value="AFH42290"/>
        <property type="gene ID" value="FFONT_0300"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
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        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="match status" value="4"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="3"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="20"/>
            <end position="76"/>
        </location>
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    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="88"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="274" mass="31183" checksum="6F45E467C6FB97CE" modified="2012-06-13" version="1">MGKMACDIKNLLNENVSFLLRTDFPTIDKNQTLTQAFKLMEKYRIDRVVVTENKIPIGIMTKKDVLNKLMVERTRLVSASRLHVSSFYTPNLYHVDERSTVADAGREMKEKKISSVAVMKDDALVGIVIRMDYSKLLSSCEEISSKSFASSLKKVVRFGERITSLREIFLKEDVVYLPVVDPNNYLAGYITVNNIADALLFYQKDTKESLRKVARKEIVVEEVMSRPPLFVYSSDPISKASKLIIEHQSRGVSVIEKDLLIGIIDDNDILRNII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZY7</accession>
    <name>H9ZZY7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 13">DNA ligase</fullName>
            <ecNumber evidence="13">6.5.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polydeoxyribonucleotide synthase [ATP]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">lig</name>
        <name evidence="16" type="ordered locus">FFONT_0304</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="13"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0304"/>
    <dbReference type="EnsemblBacteria" id="AFH42294">
        <property type="protein sequence ID" value="AFH42294"/>
        <property type="gene ID" value="FFONT_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0304"/>
    <dbReference type="eggNOG" id="arCOG01347">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005138_6_0_2"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00407">
        <property type="entry name" value="DNA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022865">
        <property type="entry name" value="DNA_ligae_ATP-dep_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="SSF117018"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 13 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_LIGASE_A3" evidence="15">
        <location>
            <begin position="340"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="13">
        <location>
            <position position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFH42294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="599" mass="67836" checksum="573DF58B5B061B2C" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A011</accession>
    <name>I0A011_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-oxoacid:ferredoxin oxidoreductase, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0328</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0328"/>
    <dbReference type="EnsemblBacteria" id="AFH42318">
        <property type="protein sequence ID" value="AFH42318"/>
        <property type="gene ID" value="FFONT_0328"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0328"/>
    <dbReference type="eggNOG" id="arCOG01605">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_1_1_2"/>
    <dbReference type="OMA" id="NYEYCKG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011898">
        <property type="entry name" value="PorD_KorD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43724">
        <property type="entry name" value="PTHR43724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02179">
        <property type="entry name" value="PorD_KorD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="3">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="98" mass="10862" checksum="A5E1F3223AF2DF44" modified="2012-06-13" version="1">MSNLKIIPSKSKLPISYPKEGAAGKTGEWRTERPIVDIKKCTRCMLCETYCPVNAIRVEKDTGATINYEYCKGCGICMNVCPVKAITMVPEQSSEVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A040</accession>
    <name>I0A040_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription elongation factor NusA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0357</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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        </source>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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</entry>
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    <accession>I0A052</accession>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
    <sequence length="185" mass="19455" checksum="B74989331803B15A" modified="2012-06-13" version="1">MKTYKLLIPVILGVALAVVYASVFVYNPVTLSLSPVSNPIQLLAGTNAGSHDLVSGNTITVTPGNNQSSLSITIHPTYQYTDYENIAIIKNTDSQSYNVWISVNNPISGLPSGSHVYLIVNGTIKGDLLTLSSSSPLNLGTLSGGNEYVIGLHVYIPEGSTLPSSASGSLYIIYSPSPETPNSTP</sequence>
</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <property type="entry name" value="ATPase_NBD"/>
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        <property type="match status" value="1"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="378" mass="42908" checksum="F1600E283ED98016" modified="2012-06-13" version="1">MTLKSIGIDPGTKSFDIVVMDEEKIIEEKSIPTEIIASNPDILIDEILKIKDFDVIIAPSGYGSPFVCNENIKDIRLFASEILLLSKYKELLNLKDEGSMVYKALYKTSVKLWKNKINACYIPSVKLLNSVELKFKINTIDCGTADKLASAFYVINYLRDRESFDIDKINFTMLEIGYGYNALIKVRRGRIVGGIGGTKLGIGHLTIGPIDAEITAYKRRWKRNDIFYGGLKDYCKTSSLDDALKSTEPICRAAVEQMFDSIFEKILILNEDTKDILIVTGRYSSSNELKEKLSSNLSKKFERIIFHPKYFENSFVKESALGQAMIGLGFMGSKYKETFDVLGIKESKGTVLDYIMHPKILELRERLLQIYEKALVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A080</accession>
    <name>I0A080_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0397"/>
    <dbReference type="EnsemblBacteria" id="AFH42387">
        <property type="protein sequence ID" value="AFH42387"/>
        <property type="gene ID" value="FFONT_0397"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0397"/>
    <dbReference type="eggNOG" id="arCOG01395">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067068_1_0_2"/>
    <dbReference type="OMA" id="NSSYCNG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007152">
        <property type="entry name" value="DUF354"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39662">
        <property type="entry name" value="PTHR39662"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04007">
        <property type="entry name" value="DUF354"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005357">
        <property type="entry name" value="UCP005357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="344" mass="40285" checksum="0123671D4AD42164" modified="2012-06-13" version="1">MKIWLDALTPKQLLLFSYTAKKVEEELNVEILLTSRNTEEIERLNRIIPFRAKLIGSYGKNFEEKLILDSKRIIDLYEVVRRFEPDILVAYPNPTASRVAFGLKKKILIFSDTPHADHAHRLSVPLADWLVFSKFLDKNLFYRYILPKFTKIVTYRGVEELAWTKDYFPNDEPIKKIGLNPFEYVVFRPPERYASYYIWDRNNLTKKIIQEIAELDKKVVLFPRYEEDSLLFKSENVIIIDVPVFGLDLEYFSALTISGGGTMAREASLLGVPSFTFFPGKIHINTALAKEGFPIYRFFELEETLKFIEMILKEPEKYRVDTKKLIKDMEDPSVVVKKLFKNNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A091</accession>
    <name>I0A091_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6 9">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1 6 9">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pgk</name>
        <name evidence="10" type="ordered locus">FFONT_0408</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 9">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1 6 9"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0408"/>
    <dbReference type="EnsemblBacteria" id="AFH42398">
        <property type="protein sequence ID" value="AFH42398"/>
        <property type="gene ID" value="FFONT_0408"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0408"/>
    <dbReference type="eggNOG" id="arCOG00496">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_2"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6 7">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 8">
        <location>
            <begin position="358"/>
            <end position="361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="415" mass="45713" checksum="B51B6D58650834AE" modified="2012-06-13" version="1">MSIKVATLDSVDLNGKKVLLRVDFNSPLNENKKIIDFSRIKIHVKTIGELIDKNASVVILTHQGRPGMEDFSDLSEHSLLLEKELGYKVNFIDDIIGPHARNSIFMLKDGEVLMLDNVRFLSEENIEASGDFHSKSYMVRKLAPLFNYFINDAFATAHRKHASIVGFPYVLPSLAGRVMESEVIALKEIRDPKISPKIFVLGGTKINDSIRIINNILKNSNSSTRVLLTGLVSELFLFASGIDIGKSNKEKLEKLGGISLLSNAKSILLNYKDRILLPEDFVIEGGGVVDIKELPKKEGLIKDIGEKTIEEYSNIMREAKVIVLRGPAGVIEEKEYMKGSIELVKNAASTNAKVILGGGHLTAVLDFIPENLRTRIHNSSGGGALLLYLSGEMLPGIEALSFSASKFNLDGIQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0B0</accession>
    <name>I0A0B0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase U62, modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0427</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="AFH42417"/>
        <property type="gene ID" value="FFONT_0427"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0427"/>
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        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
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        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
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        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="116"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="238"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="479" mass="53964" checksum="07EE9242620E235C" modified="2012-06-13" version="1">MDEDLLRKALDYALTQGAKYAEIRFHKNEENYVILRNGNLISAGKSSRKGIAIRVLYNGNLAFSSTNDISKESIFTGIDKAIANAKALNINKKENFSLSEERSLGKSKYEVYVKESFDQLPIDEKISYLKNLYMVALDSMKNAKLNAMFESYSDEIEEKVIVNSDGGYVESKIPRLYFFGNIIIYDPQKGSMQKMIEKGASGGLELLKGWRLEDEIKNDLKSLEKVLLEGKSPPKDAVDVVVGSEIVGLIVHESAGHPMEADRIWGRESAQAGESFVKPEMIGKVYIGNSNATVIDDPTIPESNGFYLYDDETVPARKRYIYYKGLLNEPLHNRWTASVFKTNSNGGARAMDYTSEPIVRMSNTYLEPGDMTFEELIEDINFGIFIKSYMEWNIDDIRWGQRYVGLESYLIERGEISEPVLNPVLQFNTREFYSSIISKDKNLEFSSGTCGKGEPHQGVPVWHGGPNIRLSKMKVGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0D0</accession>
    <name>I0A0D0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">infB</name>
        <name evidence="9" type="ordered locus">FFONT_0447</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6 7">Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42437">
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        <property type="gene ID" value="FFONT_0447"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG01560">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002656_3_3_2"/>
    <dbReference type="OMA" id="FRQSKPA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="IF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004544">
        <property type="entry name" value="TF_aIF-2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
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        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aIF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="15"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="606" mass="67315" checksum="7C6FF79A0DF68722" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0D1</accession>
    <name>I0A0D1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 3">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1 3">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name evidence="5" type="ordered locus">FFONT_0448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1 3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0448"/>
    <dbReference type="EnsemblBacteria" id="AFH42438">
        <property type="protein sequence ID" value="AFH42438"/>
        <property type="gene ID" value="FFONT_0448"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0448"/>
    <dbReference type="eggNOG" id="arCOG04313">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <feature type="domain" description="NDK" evidence="4">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
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        </location>
    </feature>
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        <location>
            <position position="11"/>
        </location>
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        <location>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:30616"/>
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        <location>
            <position position="93"/>
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        <ligand>
            <name>ATP</name>
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        <ligand>
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        <ligand>
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        </ligand>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42438.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="141" mass="16169" checksum="868C3FDF7C443FD8" modified="2012-06-13" version="1">MAIERTFVMIKPDAVERKLIGEIISRFERKNLKIVAMKLIKMTKEQAKELYIPHKDKPFYNDLVNFATRGPVVVMVLEGDSAVEVVRTLIGSTDGRKALPGTIRGDFALDIQENVIHASDSKESYEREHKIFFLESELLKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0D5</accession>
    <name>I0A0D5_FERFK</name>
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            <shortName evidence="6">GluRS</shortName>
        </alternativeName>
    </protein>
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
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            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="6"/>
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        <property type="protein sequence ID" value="AFH42442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0452"/>
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        <property type="protein sequence ID" value="AFH42442"/>
        <property type="gene ID" value="FFONT_0452"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
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        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="8">
        <location>
            <begin position="101"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="9">
        <location>
            <begin position="415"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="6">
        <location>
            <begin position="108"/>
            <end position="118"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="580" mass="66537" checksum="FD6AA00DA0FE48EC" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0G6</accession>
    <name>I0A0G6_FERFK</name>
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        <submittedName>
            <fullName evidence="3">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42473">
        <property type="protein sequence ID" value="AFH42473"/>
        <property type="gene ID" value="FFONT_0483"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="PHAALWR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="4"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="157" mass="17543" checksum="C8A0C0EACA92A8BF" modified="2012-06-13" version="1">MSARPLVGVGAVVFNEKGEILLVKRIYPPQEGKWAIPGGHLELEETIFDGAKRELYEETGLIGDAKCIVNVDELIVLKEDKSVWRHYILIDVLFENVRGELKAGSDAGDAKFFSPSEAINSKDTSYSTINFLKKYINGDIICGLPVLNKYIEKIDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0H1</accession>
    <name>I0A0H1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42478">
        <property type="protein sequence ID" value="AFH42478"/>
        <property type="gene ID" value="FFONT_0488"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0488"/>
    <dbReference type="eggNOG" id="arCOG04189">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1623401_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="163" mass="18045" checksum="D9844055DEA85144" modified="2012-06-13" version="1">MSKDKYIGILLIAVSAIVIVLYGYILFLTSYSGILIELTAFIAILGIFGIVGWIGYTLATTPPPKPIEEIEKEIDEELKKLEQEQNVEQKTRSEGNAQGEKKENIVGNYSDQTAKAVEQKEVSSLLKDEEKDSNSGKGNEDAVGEVVKKEKGHIRKSRKSKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0H2</accession>
    <name>I0A0H2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bifunctional phosphoglucose/phosphomannose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PGI/PMI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0489"/>
    <dbReference type="EnsemblBacteria" id="AFH42479">
        <property type="protein sequence ID" value="AFH42479"/>
        <property type="gene ID" value="FFONT_0489"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0489"/>
    <dbReference type="eggNOG" id="arCOG00052">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059687_0_0_2"/>
    <dbReference type="OMA" id="FPELNHN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SIS_PGI_PMI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019490">
        <property type="entry name" value="Glu6P/Mann6P_isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
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        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10432">
        <property type="entry name" value="bact-PGI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="3">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="331" mass="37236" checksum="49AF1AFC9178E23B" modified="2012-06-13" version="1">MNKLNKIFEKWYELAKIGLEKGLNEECIDFSPREIVIVGMGGSGIVGNTLEDISHFYGMNAKVTTVKSNVIPFKPDERSLFIVISYSGNTIETLSAYKQLLEENAKTLVITSGGLLEKFAIENKSCMIKLTPKLLPRGDFPEIFYSILGLLVKNNVLRAINNEKLHSSIEVLKEDLENYAKNIANEAKDKIVIFISSKPYLSVAIRFKNDFAENSKSISFVEEIPEFLHNSIEGINRLLMFYKDRIKILSIGGKMLFNNIFYESFKEALNLKITEVDLGSDGVLNEIVRGFKLSGLVSLKLASIYDIDPDETSSIDVYKEKLSSVLGNRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0H8</accession>
    <name>I0A0H8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0495</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0495"/>
    <dbReference type="EnsemblBacteria" id="AFH42485">
        <property type="protein sequence ID" value="AFH42485"/>
        <property type="gene ID" value="FFONT_0495"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0495"/>
    <dbReference type="eggNOG" id="arCOG04168">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3002986_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_L34Ae"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="56" mass="6150" checksum="E5FFEC748D7BE3F3" modified="2012-06-13" version="1">MYCGRPLGGTPNGSYVEIKRLSKTKKRPNRIFGGVVCPECLAKIIKNEARKLVATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0J5</accession>
    <name>I0A0J5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component 1</fullName>
            <shortName evidence="6">RNase P component 1</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Rpp29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rnp1</name>
        <name evidence="7" type="ordered locus">FFONT_0512</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <text evidence="6">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
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        <property type="protein sequence ID" value="AFH42502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:ribonuclease P activity"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
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        <property type="entry name" value="RNP1"/>
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        <property type="entry name" value="Rof/RNase_P-like"/>
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    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="94" mass="10871" checksum="30FF1B49FA55D767" modified="2012-06-13" version="1">MKKSNITFGDLFGSEVEVLMYPDRNVIGLIGIVENETQKTISIYRNEKTITLFKDYIVFKIRSKNSETVIYGNEIVGRPEDRTKEVIKKKIGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0M2</accession>
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        <submittedName>
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    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42529">
        <property type="protein sequence ID" value="AFH42529"/>
        <property type="gene ID" value="FFONT_0539"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="224" mass="24576" checksum="55CC6121D2D850CE" modified="2012-06-13" version="1">MNIYRGIGLSLMISGIPAAIFIFLLTRNTPFTALFVGISILGASMFLTPEEESWVSKDLSLMLYSEFSNIASLLETFRISSFNKFVAYGEKVYLFLSEGSLEKAPDEPPNFLISVLDGKTVLSLESPINREIIEGNTSFCSAADFVLVEKLNVADKIECAEGNDIYSVKVYGTLIKDPLRTAKAFGGFYGLILGSIASILKGEASVVSFDESENYKIIKVSIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0M8</accession>
    <name>I0A0M8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="1" type="ordered locus">FFONT_0545</name>
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    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0545"/>
    <dbReference type="EnsemblBacteria" id="AFH42535">
        <property type="protein sequence ID" value="AFH42535"/>
        <property type="gene ID" value="FFONT_0545"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0545"/>
    <dbReference type="HOGENOM" id="CLU_3093950_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="51" mass="6096" checksum="67875EB13B45B40E" modified="2012-06-13" version="1">MHLFVFTSYIYGTERAVRDLFSKDKILKIFKNHSALKSWAFGCFYEVPENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0N1</accession>
    <name>I0A0N1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-fuculose phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L-fuculose-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0548</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:12933"/>
            <dbReference type="ChEBI" id="CHEBI:18041"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57846"/>
            <dbReference type="EC" id="4.1.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; coenzyme F420 biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.17" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0548"/>
    <dbReference type="EnsemblBacteria" id="AFH42538">
        <property type="protein sequence ID" value="AFH42538"/>
        <property type="gene ID" value="FFONT_0548"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0548"/>
    <dbReference type="eggNOG" id="arCOG04226">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="ICRYGRS"/>
    <dbReference type="UniPathway" id="UPA00071"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008738">
        <property type="term" value="F:L-fuculose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="6">
        <location>
            <begin position="7"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="216" mass="23813" checksum="96234B44D1CF5180" modified="2012-06-13" version="1">MYDDLKKKVVEVMKFMEQHELNYGRSGNVSIRIQDTGHILITPTGVKKSALAEDDIAVVDLSGKTIEGKRKPSVEMPLHLAIYKNYDYINAVIHAHGIYSTALAVAREPLPPLVEEMVSLTGGDVKVAEYAPSGTDELAENAVKALHERKAVLLANHGIVACGETIDEALEILVLVERISKVYILSKVAGVPKVLPFESLEKQVQDFRKRIKRNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0P3</accession>
    <name>I0A0P3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3">N5-CAIR mutase</shortName>
            <ecNumber evidence="3">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purE</name>
        <name evidence="6" type="ordered locus">FFONT_0560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0560"/>
    <dbReference type="EnsemblBacteria" id="AFH42550">
        <property type="protein sequence ID" value="AFH42550"/>
        <property type="gene ID" value="FFONT_0560"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0560"/>
    <dbReference type="eggNOG" id="arCOG02464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_2_2"/>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="5">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="134" mass="14290" checksum="1682A1165A57B9B9" modified="2012-06-13" version="1">MTCKGKVSIIVGSERDLPFSERASKILKENSIEFEIKVLSAHRNPKDLENYISNSDVDVFIAMAGLSAHLPGFIASRTNKPVIGVPLNVSLGGLDSLLSIVQMPKGVPVATVGIDNPENAAHLAVRIISLCRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0R5</accession>
    <name>I0A0R5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MS_channel domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0582"/>
    <dbReference type="EnsemblBacteria" id="AFH42572">
        <property type="protein sequence ID" value="AFH42572"/>
        <property type="gene ID" value="FFONT_0582"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0582"/>
    <dbReference type="eggNOG" id="arCOG01568">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1092418_0_0_2"/>
    <dbReference type="OMA" id="HIWNYRK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045275">
        <property type="entry name" value="MscS_archaea/bacteria_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30221">
        <property type="entry name" value="PTHR30221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="249" mass="28585" checksum="B2B4CCCA78B02EC0" modified="2012-06-13" version="1">MILFGLSNEFVIRVIISVIFIIFIYFFVKYLDKLINKVFSRIDPSLRLEVKSVFSYAIYVLGALIAISIISPQTSILDVIILLLGLAIVISFADVLRNWGIQFLLRGTKSFKIGDWIEVDGIFGRVISIEDNGIFLETARRERIFISNIRLSNSIIINRTTPIGYMYRVRIYIPQTVKPLEALERVKEIVSKIKGELSSEPTVLLGLEKNMTVVDLTMEFLNVYKLEVFSEKVLEEVLREFPEAVIKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0S5</accession>
    <name>I0A0S5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps10</name>
        <name evidence="6" type="ordered locus">FFONT_0592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0592"/>
    <dbReference type="EnsemblBacteria" id="AFH42582">
        <property type="protein sequence ID" value="AFH42582"/>
        <property type="gene ID" value="FFONT_0592"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0592"/>
    <dbReference type="eggNOG" id="arCOG01758">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_0_1_2"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_S10_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S10" evidence="5">
        <location>
            <begin position="12"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="108" mass="12484" checksum="C0C723D8B3A259D1" modified="2012-06-13" version="1">MGVKLMPATMARIRLWSANVESLDKVTSQIKAIAEKGGVKMRGPVPLPTKRLVVPVLRLPHGEGSKHWEHWEMRIHKRLIDIASDERIMRQIMRVRVPEDVYIEIELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0S6</accession>
    <name>I0A0S6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor 1-alpha</fullName>
            <shortName evidence="5">EF-1-alpha</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Elongation factor Tu</fullName>
            <shortName evidence="5">EF-Tu</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tuf</name>
        <name evidence="7" type="ordered locus">FFONT_0593</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0593"/>
    <dbReference type="EnsemblBacteria" id="AFH42583">
        <property type="protein sequence ID" value="AFH42583"/>
        <property type="gene ID" value="FFONT_0593"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0593"/>
    <dbReference type="eggNOG" id="arCOG01561">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_3_5_2"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="9"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="18"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="441" mass="48947" checksum="D594B4C4CCE26225" modified="2012-06-13" version="1">MRVIPMSEKPHLNLVVIGHVDHGKSTTVGHILYRLGYVDPKKLAELEEEAKKKGKESFKYAWLLDNLKEERERGVTIDLSFMKFETKKYYFTIIDAPGHRDFVKNMITGASQADAAILVVSARKGEFEAGMSPEGQTREHLILAKTMGIEQIIVAVNKMDATEPPYSQERYKQVIDTLQKFMKGLGFDISKIPFIPISGWNGDNLIERSPAMPWYNGPTLVEALDNIQIPPKPIDKPLRIPIQAVYAISGIGTVPVGRVESGVLKKGDRIVFMPPAIVGEVRSIEMHHTQIEKAEPGDNIGFNVRGVTKTDIKRGDVAGHLTNPPTIAKEFTARLFIIWHPSAVTVGYTPVIHAHTASIAAKITELVSKLDPRTGKEAEKNPQFLKQGDTAIVKFQPIKQMVVEKFSEFPALGRFAMRDMGKTIGIGVITDVVPEQVQIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0U8</accession>
    <name>I0A0U8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein-alanine acetyltransferase RimI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0615"/>
    <dbReference type="EnsemblBacteria" id="AFH42605">
        <property type="protein sequence ID" value="AFH42605"/>
        <property type="gene ID" value="FFONT_0615"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0615"/>
    <dbReference type="eggNOG" id="arCOG00833">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_0_2"/>
    <dbReference type="OMA" id="YFGPGED"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="151" mass="17528" checksum="89735ECDA5808667" modified="2012-06-13" version="1">MTAEISFSIESASMRDLKEVYEIELSSFPRYPYSISVLVSFLTLFPELFLIARHEERIVGYIAGFMEKEDRGHIASIAVRQEYRGRGIGRKLLEEEENKMRNLDVKEVVLEVSENNEVAIRLYTSMGYKKIKRVKNYYPDGSAAFIMKKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0V5</accession>
    <name>I0A0V5_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0622"/>
    <dbReference type="EnsemblBacteria" id="AFH42612">
        <property type="protein sequence ID" value="AFH42612"/>
        <property type="gene ID" value="FFONT_0622"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0622"/>
    <dbReference type="HOGENOM" id="CLU_1145181_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="242" mass="26532" checksum="0FA64BE360E62E06" modified="2012-06-13" version="1">MSSIFSLYQAQQYSYQMPFGAKLGEGYYLSVICSGGGNEGILLPDYMREEFPVNSTVEINGDGYRVLGYTGSNSSLAVLYSRSCNSFSQQLSPMQVLLNSALKEAFGISILWISFSLILSSLTTALLMLKNRERAEGEIKALISMGIRRRHFLLSSILYSLILSLLSSFMALSIGIFSMKLVAYASSSLFNLSILQPYITLDHALSLLSVSALSVFVPSFSISWAEFRMCMKNATEQGGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0W1</accession>
    <name>I0A0W1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0628"/>
    <dbReference type="EnsemblBacteria" id="AFH42618">
        <property type="protein sequence ID" value="AFH42618"/>
        <property type="gene ID" value="FFONT_0628"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0628"/>
    <dbReference type="eggNOG" id="arCOG01369">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_2"/>
    <dbReference type="OMA" id="NLGNEDW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="323" mass="36173" checksum="11813F0971FCA1D9" modified="2012-06-13" version="1">MNSRILVTGGAGFIGSHLVDRLIERGEEVLVIDDLSSGKTENLERWFGEKKFKFIKADLSEPGKWIDELKGIEAVFHFAANPEVRVSTTNPEVHYRANVQATFNVLEASRANGAEIFIYASSSTVYGEARVIPTPEDYEPKEPISIYGASKLMGEVLVSTYSRIYGVKSAMLRFANVVGKRSNHGVIFDFIAKLKRDPERLEILGDGKQRKSYIYIDDAIEATLKVMEHMESSQEMSEAFNVGSLDAIGVDDIAYIIEEEMGLGKVEHVFKSATHDGRGWIGDVKVMQLDVSKIMGKTNWKPKMNSREAVRKATKDLLERMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Z5</accession>
    <name>I0A0Z5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0663"/>
    <dbReference type="EnsemblBacteria" id="AFH42652">
        <property type="protein sequence ID" value="AFH42652"/>
        <property type="gene ID" value="FFONT_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0663"/>
    <dbReference type="eggNOG" id="arCOG05120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080107_0_0_2"/>
    <dbReference type="OMA" id="YVILYPH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="34"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="257" mass="29516" checksum="1D6D52FF3FC6102B" modified="2012-06-13" version="1">METGYDPIALGKIIEEVVTRREGGSLYRKYYRFRGGRWYGGIATADAVGCNLKCKFCWSWRQRDSPRSYGEFYSPEAVAERLSLIAEEKGYSYVRISGGEPTLGFEHLLGVLRTFRDRDKTFILETNGIYLGYSRELAQELSPFVNLHVRVSIKGCNSEEFFEITGARQEFFELQIRALENLLDAGVEAHPAVMMSFSGEESCRELKERLGSIDPSLEESFEEEYVFLYPHVVELMNRHGIWPKKAFSPDGIPREFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I0A152</accession>
    <name>I0A152_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Plasma-membrane proton-efflux P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FFONT_0721</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0721"/>
    <dbReference type="EnsemblBacteria" id="AFH42709">
        <property type="protein sequence ID" value="AFH42709"/>
        <property type="gene ID" value="FFONT_0721"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0721"/>
    <dbReference type="eggNOG" id="arCOG01578">
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</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="99" mass="11472" checksum="69FD029B143469DD" modified="2012-06-13" version="1">MEEKRKLVVYGLKGCSPCERAFLFLKKAGIEFEYVEISNCDDANIEEVLFYEDGEALLPLILDKKTESILIGCPKSYERFIEELRKSIKIYAINDKQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
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    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <ligand>
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    </evidence>
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        <source>
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</entry>
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                <person name="Bidzhieva S.Kh."/>
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    <sequence length="43" mass="5172" checksum="C13B679EEB6D6123" modified="2012-06-13" version="1">MKYLNFKSFKNILKLFELSEGIEERTAYNEINRAFKEMKLIGN</sequence>
</entry>
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            <begin position="6"/>
            <end position="76"/>
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    <evidence type="ECO:0000256" key="1">
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</entry>
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</entry>
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        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Proteasome regulatory particle</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pan</name>
        <name evidence="8" type="ordered locus">FFONT_0825</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0825"/>
    <dbReference type="EnsemblBacteria" id="AFH42813">
        <property type="protein sequence ID" value="AFH42813"/>
        <property type="gene ID" value="FFONT_0825"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0825"/>
    <dbReference type="eggNOG" id="arCOG01306">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_2_4_2"/>
    <dbReference type="OMA" id="YNMTTFE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022623">
        <property type="term" value="C:proteasome-activating nucleotidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036402">
        <property type="term" value="F:proteasome-activating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00553">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005937">
        <property type="entry name" value="26S_Psome_P45-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023501">
        <property type="entry name" value="Nucleotidase_PAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01242">
        <property type="entry name" value="26Sp45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="198"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="19"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="209"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="424" mass="47895" checksum="B8DA00955727952E" modified="2012-06-13" version="1">MESADDISNANSTNVLAHIKYLEEKLKVLEEEKARLEKDINSYKEEKEKYIKYLEEKIKELEEEKLMLNREVKYYKEEMEKLLAPPLIEASVLDILPDKRVVVRSSTGPNLIVTVSGNISVDQLLPGTIVAINQRGSSIVEVLPQREDPYVKAMEVIERPNVKYKDIGGLSKQIQEVRETVELPLKKPELFKKIGIEPPKGILLYGSPGTGKTMLAKAVASETNATFIRVVGSEFVQKFIGEGARIVREVFELAKRKAPAIIFIDEIDAIAARRIDIGTSGEREVQRTMMQLLAEMDGFDPLDNVKVIAATNRIDILDPAILRPGRFDRIIEVPLPDKQGRIEIFKIHIKKMNVEKNLDIRKLSELTEGFVGADIKAVCVEAGYNAIREERDLVTMEDFIKAIEKIKGRKKEVEPEVPQVSTAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1G3</accession>
    <name>I0A1G3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0832"/>
    <dbReference type="EnsemblBacteria" id="AFH42820">
        <property type="protein sequence ID" value="AFH42820"/>
        <property type="gene ID" value="FFONT_0832"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0832"/>
    <dbReference type="eggNOG" id="arCOG01260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_2"/>
    <dbReference type="OMA" id="GICEFKE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="263" mass="28695" checksum="E6AA1FD1DE3323A7" modified="2012-06-13" version="1">MSAFNIGNTKVLVTASTRGIGFGIAKVLLENGAKVVINGRSEEGVIKAIEKLQYPYKNNAKGIVADISNKDEAIRLVKESAKSLGGLDSLVYVTGPPKPGYFNELNYDDWEEGVNLLINSAIVLAKESIPFLKESKNPSMIFLTSIAVKEPIPNIALSNVLRISVHGLVKTLSKELARYKIRVNAVLPGHIETERSLQLASDRAKRENRTIEEVLNDMTKEIPLGRLGKPEEIGYTVAFLISPYSSYITGAFIPVDGGVLRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1H0</accession>
    <name>I0A1H0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0839"/>
    <dbReference type="EnsemblBacteria" id="AFH42827">
        <property type="protein sequence ID" value="AFH42827"/>
        <property type="gene ID" value="FFONT_0839"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0839"/>
    <dbReference type="eggNOG" id="arCOG11396">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2597546_0_0_2"/>
    <dbReference type="OMA" id="WLYESAG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="79" mass="9372" checksum="EA8B9E84D1513676" modified="2012-06-13" version="1">MKSEKDREIKEILLRDLFSIKKDSLEEISEWLYEEYGIKAEPKEEVLKKKILSSKEITSHDIALLIIENGGYVNEQLWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1J4</accession>
    <name>I0A1J4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0863</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
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                <person name="Perevalova A.A."/>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
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                <person name="Bidzhieva S.Kh."/>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:57743"/>
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        </reaction>
    </comment>
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            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <location>
            <begin position="33"/>
            <end position="173"/>
        </location>
    </feature>
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        <location>
            <begin position="179"/>
            <end position="332"/>
        </location>
    </feature>
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        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
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            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
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            <end position="260"/>
        </location>
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        <location>
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            <end position="296"/>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
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        <ligand>
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        <ligand>
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        <ligand>
            <name>L-ornithine</name>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="255"/>
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        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:46911"/>
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    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="323"/>
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        <ligand>
            <name>carbamoyl phosphate</name>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
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        <source>
            <dbReference type="RuleBase" id="RU003634"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02729"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="336" mass="37837" checksum="87C7770D3F247B8F" modified="2012-06-13" version="1">MRENNLKISKILKNLLYFINYKNKWRSFYFMAKSLLSVADLSKDEINEILDRAKELKKSIKSRQELNILKNKVVGLLFEKPSTRTRTSFEVAALRLGGSAVYLSANELQLSRGEPIKDTARILGSFLDAIVARVYSHNTVVELAKYANVPVINGLSDLEHPTQILSDMLTIIEAKGKLEGLNFVFIGDGNNMCNSWLLGSAIVGMNMTAAIPKGYYPDQKILDKALEIAKKTGSKIKIVNDPKEAAKDADILYTDVWVSMGQEKETEKRMKDFQGYQINKELLRLAKKDVVVMHCLPAHRGLEITDDVIEGEQSIVWVQAENKLYGAAAVLEYYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1N9</accession>
    <name>I0A1N9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable inosine/xanthosine triphosphatase</fullName>
            <shortName evidence="2">ITPase/XTPase</shortName>
            <ecNumber evidence="2">3.6.1.73</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Non-canonical purine NTP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Non-standard purine NTP phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Nucleoside-triphosphate phosphatase</fullName>
            <shortName evidence="2">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + ITP = H(+) + IDP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28330"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58280"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + XTP = H(+) + phosphate + XDP</text>
            <dbReference type="Rhea" id="RHEA:28406"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59884"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.73"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="2">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YjjX NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.73" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0908"/>
    <dbReference type="EnsemblBacteria" id="AFH42896">
        <property type="protein sequence ID" value="AFH42896"/>
        <property type="gene ID" value="FFONT_0908"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0908"/>
    <dbReference type="eggNOG" id="arCOG01221">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087417_0_1_2"/>
    <dbReference type="OMA" id="ADYWVGI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103023">
        <property type="term" value="F:ITPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00648">
        <property type="entry name" value="Non_canon_purine_NTPase_YjjX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002786">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026533">
        <property type="entry name" value="NTPase/PRRC1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01931">
        <property type="entry name" value="NTPase_I-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00258">
        <property type="entry name" value="TIGR00258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 2" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTPase_I-T" evidence="3">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="177" mass="19899" checksum="A4E2A501E574AC02" modified="2012-06-13" version="1">MVFVCIGTKNVSKITGIERAFSSFYEEVQLLAIDLSYKLPPQPIGIKEIMSGAEKRAKEAIKSSEMCEFGVGVEAGLIKIEESYYDIQASFVINKDGRGYFGFSPSFIIPKSFSEGIITKKYRELEEVTDAYFNTENVGEKGGVIKLLTKGRVTREDLTYYAVMMSLIPFQNSNLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1P7</accession>
    <name>I0A1P7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42904">
        <property type="protein sequence ID" value="AFH42904"/>
        <property type="gene ID" value="FFONT_0916"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0916"/>
    <dbReference type="eggNOG" id="arCOG05941">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143937_1_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="141" mass="16706" checksum="6FA16C706C56579A" modified="2012-06-13" version="1">MVKATKLVVRNEKIVKAFECYKEKIKEYNKKVSGMGYYLKPVHIVTKKVGEEIRIYRYFGKYWWKIEYLGLKGNKPVIKWIYIGKNKPIESLPDPPINPLEGFSFYTLKGDKDHIYVSERTYTKFQNKIEKILLGEKICSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Q0</accession>
    <name>I0A1Q0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-octaprenyl-4-hydroxybenzoate carboxy-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0919</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0919"/>
    <dbReference type="EnsemblBacteria" id="AFH42907">
        <property type="protein sequence ID" value="AFH42907"/>
        <property type="gene ID" value="FFONT_0919"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0919"/>
    <dbReference type="eggNOG" id="arCOG01671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_4_1_2"/>
    <dbReference type="OMA" id="SYQQFWG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="496" mass="55747" checksum="7FAFF41F8837F725" modified="2012-06-13" version="1">MILLNPLLGIKEYVEWLEERELLVRVKEPLSPILEIPYFLRKVMYSSGPAVLFESVKGFEGWRVCGNLFPSVFTISSALGINSFEEISERLISLITHQQAQGITEKIKAFSDASKLLGYFPKKVNKAEFEEKVIEGKDNPLDKIPFFKTWPMDGGRYATFPMVITKDPAKGIINMGVYRVMIVNGRKGIIHWQVHKRGAMAYSVTKEMKAKEMPVAIIIGSDPGTMISAVSPVPYPIDKMLFAGMVRGRGVELFELDNGIPVPSNSEIVIEGSVRVDELASEGPFGDHWGYYDTPTEMYPVFTVERVYMRENPIYYGSVTGLPPLEDAVMGKIVEKMFKPFIKLLLPEVVDISYPVYGIFQGMVVVSIKKRYPGQAKKVMNALWGLAQSSLTKIVIVVDEDIDVNNLDKVIWAVSSNVEPQRDVVVIPYTHTDALDPASISHSYGGKLGIDATRKLPEENFGREWPKIVEDDKNVKEKIDPLVEKLLKSFKGLDRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1T5</accession>
    <name>I0A1T5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0954</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Ravin N.V."/>
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    <keyword evidence="2" id="KW-0946">Virion</keyword>
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        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43041.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="146" mass="16413" checksum="416803BDE2006EEF" modified="2012-06-13" version="1">MASKRVFSELNALLDKQVTIKLKDGRTIKGTLYGFDDKLNILLKNATENEGNSSVPTMLIYSDYIAYLSAIEAPIFNPDEFARLIVSKLNIREADIKTYPEAGVLVILNNIRVSDKGVEGSGPLAHKIYGLYTEYIENKKKEIEKR</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="248" mass="26762" checksum="86FB5C74D8C12EBD" modified="2012-06-13" version="1">MGKMSFKNRTSIVTGSAMGIGKGIAQKLASLGSNLILFDISDKIFETAKEIEHLEVEVLPFKGDVTNKEDVERSVEEGISKFGKIDILVNNAGIYPSKPFIEMTESDWDRVLNINLKSMFLFSKAVLPNMMKNSYGRIVNISSIAAIVGFPGLIHYSASKGGVVGFTKALALEVAKFGITVNAIAPGPIETSGTKVDEQTAEIYKRLIPVGRMGKPEDIANAVAFLASEESQFITGHLLVVDGGYTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="AcnX_sub2_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002840">
        <property type="entry name" value="AcnX_swivel_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01989">
        <property type="entry name" value="DUF126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004966">
        <property type="entry name" value="UCP004966"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF126" evidence="1">
        <location>
            <begin position="24"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="129" mass="14297" checksum="AA1FCFBC71E35C3C" modified="2012-06-13" version="1">MRIRVKILNEGDAEGEIVAYNFPISFLGEVNAKNGEIIFKDKKISIKDKILIFPNTRGSTVGSYVIYALKYYNNAPKAIIVEKAEPILIAGCVLSGIPLAEDLEGNLLKEAKKYSKAKLDSKEGILFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A263</accession>
    <name>I0A263_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH43070">
        <property type="protein sequence ID" value="AFH43070"/>
        <property type="gene ID" value="FFONT_1082"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1082"/>
    <dbReference type="HOGENOM" id="CLU_2534515_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="83" mass="9540" checksum="418A9777219C3996" modified="2012-06-13" version="1">MPYEVLFKNLDEANEKVKKLVKEPDLCLIKVNKENVKLKIRDKNKLYTLVFSKENVGVSSVEELKKVATDIATKISCKETKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A266</accession>
    <name>I0A266_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase</fullName>
            <ecNumber evidence="2">2.7.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_1085</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15669"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:13184"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:136416"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end dephospho-ribonucleoside-RNA + ATP = a 5'-end 5'-monophospho-ribonucleoside-RNA + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54580"/>
            <dbReference type="Rhea" id="RHEA-COMP:13935"/>
            <dbReference type="Rhea" id="RHEA-COMP:13936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:138284"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.78"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.7.1.78" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1085"/>
    <dbReference type="EnsemblBacteria" id="AFH43073">
        <property type="protein sequence ID" value="AFH43073"/>
        <property type="gene ID" value="FFONT_1085"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1085"/>
    <dbReference type="eggNOG" id="arCOG04127">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051301_1_0_2"/>
    <dbReference type="OMA" id="RKIHREM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="PTHR12755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLP1_P" evidence="6">
        <location>
            <begin position="108"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH43073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="414" mass="46930" checksum="996C16580B3D7BEF" modified="2012-06-13" version="1">MEKILETNEIEKFYFIKGPAKINVLRGKVEINGILFDKGESVVIHKSRSYILRIEKNSKISVIGENDFCIRDAINEEIEVYTDWKKYSSLIVEECANKEKTCKVIVLGKVDSGKTTFSSMIANTAYLKGMETYYVDTDLGQKTFGYPGSVTISKNSGKLFWSTASKSDKFIFIGKLSPVGKESDVIQATEELIAGIEKGIIIIDTDGWFGDPLSLNYKFRMIQKIKPDYTVIIRSGQKIDLFVKSIFPITKIITLNTPPNKASRSKIERKMIRGDKVLSLIESKKSRLLTYGSFFTLGEITIGFGNPLSYNELTELSNKIGDKVLYGEDYDEKTVVIVERLKRNNFKDFYVINTNNLKGKIVSVLNDKGEHIDIGFLTDINEYGFLIKTSYEKEIKGLYIGNITIFDFKLENSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A281</accession>
    <name>I0A281_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exosome complex component Csl4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">csl4</name>
        <name evidence="5" type="ordered locus">FFONT_1100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1100"/>
    <dbReference type="EnsemblBacteria" id="AFH43088">
        <property type="protein sequence ID" value="AFH43088"/>
        <property type="gene ID" value="FFONT_1100"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1100"/>
    <dbReference type="eggNOG" id="arCOG00676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067135_1_1_2"/>
    <dbReference type="OMA" id="CGNVETR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00975">
        <property type="entry name" value="Exosome_Csl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030850">
        <property type="entry name" value="Exosome_Csl4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="PTHR12686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0271">Exosome</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="66"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="191" mass="21000" checksum="EE43B79F6F296011" modified="2012-06-13" version="1">MMKEENLAFPGDELAILEEFIPVSGVYSDENGKLRSTLIGKVVKDIINKNLKVIPFKKKYDFPRLKSVVIGYVNSVKSDIALITILYDGNLKPISAPLAGFLHVSQVDEEGKNISDYVLPGDLVKAKIISSENPFQLSFKHSSLGVILASCSKCGAIMQKLENGKLKCPKCGNIENRKLSSDYINLKDHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2A5</accession>
    <name>I0A2A5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase small</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1124"/>
    <dbReference type="EnsemblBacteria" id="AFH43112">
        <property type="protein sequence ID" value="AFH43112"/>
        <property type="gene ID" value="FFONT_1124"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1124"/>
    <dbReference type="eggNOG" id="arCOG00109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_2_2"/>
    <dbReference type="OMA" id="AWDAGHD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="31"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="207" mass="23371" checksum="9C103CCB9F867862" modified="2012-06-13" version="1">MTHVLLSRITKLFKYKGLYVYIPEGVFNPTFTLSTSLIIDYLNEFKPKGKVLEIGCGTGAISIYIAKKFGLKSYCTDISEVALATAKINSKINGVEKNIEVLKTEKLRYVASFDLVITNPPYLPLEPIDSLDLNWCGGRDLNLLKEAILLGRKALRKKGEMIITLSSLTDLTLLDDFLKKQGFFMVGIKRRVSPFDLVFLYHLKLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2B8</accession>
    <name>I0A2B8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holliday junction resolvase Hjc</fullName>
            <shortName evidence="10">Hjc</shortName>
            <ecNumber evidence="10">3.1.21.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">hjc</name>
        <name evidence="11" type="ordered locus">FFONT_1137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the Holliday junction resolvase Hjc family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="10"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1137"/>
    <dbReference type="EnsemblBacteria" id="AFH43125">
        <property type="protein sequence ID" value="AFH43125"/>
        <property type="gene ID" value="FFONT_1137"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1137"/>
    <dbReference type="eggNOG" id="arCOG00919">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139546_1_0_2"/>
    <dbReference type="OMA" id="RITRFMR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01490">
        <property type="entry name" value="HJ_Resolv_Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002732">
        <property type="entry name" value="Hjc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014428">
        <property type="entry name" value="Hjc_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39651">
        <property type="entry name" value="PTHR39651"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01870">
        <property type="entry name" value="Hjc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004985">
        <property type="entry name" value="Hlld_jn_rslvs_ar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH43125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="145" mass="16674" checksum="2EFDF269DEF51F84" modified="2012-06-13" version="1">MKKMDIEKRKNRIRGFQKERDLVRKLWEMGFATIRAPASGAKAKKTYQPDIIAAKNNRIFVIEVKTRRATDTVYVDSFQVSKLKEWSSRAGSNARCFIAVYFDRKIGWKFVPLEKAEVTKDGNIKVTKDLASNSLSLDDLNNLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2B9</accession>
    <name>I0A2B9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylacetic acid degradation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1138"/>
    <dbReference type="EnsemblBacteria" id="AFH43126">
        <property type="protein sequence ID" value="AFH43126"/>
        <property type="gene ID" value="FFONT_1138"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1138"/>
    <dbReference type="eggNOG" id="arCOG01845">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091588_2_2_2"/>
    <dbReference type="OMA" id="LRMIIDP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeS_assembly_P" evidence="1">
        <location>
            <begin position="11"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="132" mass="15183" checksum="0B7AD246BAFE5EC4" modified="2012-06-13" version="1">MSEAINKSEIREKIIEALKGVYDPEIPVNIYDLGLIYEIQVNDDMSVYIRMGLTTPFCPMVSSIVSVVEEEVEKKLSSLGFKKVYVDIDISKPWSAKMITKEGREQLKSIYGYDIVEEMIKREEEMMSSEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2C3</accession>
    <name>I0A2C3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0201 protein FFONT_1142</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0201 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1142"/>
    <dbReference type="EnsemblBacteria" id="AFH43130">
        <property type="protein sequence ID" value="AFH43130"/>
        <property type="gene ID" value="FFONT_1142"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1142"/>
    <dbReference type="eggNOG" id="arCOG01043">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134829_1_0_2"/>
    <dbReference type="OMA" id="VARSKCI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01112">
        <property type="entry name" value="UPF0201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39652">
        <property type="entry name" value="PTHR39652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="142" mass="16290" checksum="B9B8AF2E2030D43C" modified="2012-06-13" version="1">MEIPVKPTESEKNLALLVEKIMEPEEIYSEDLGIEKKIVARSKCISSLKKMHYLLRSERILDSARRYLKEGVADKMIVVMLHKQALAAGRISFVSEERESPLGAVKLYIYHDNPHDVIDWLAPPTRKGRPVFERGVPEPDCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2F2</accession>
    <name>I0A2F2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable tRNA sulfurtransferase</fullName>
            <ecNumber evidence="6">2.8.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sulfur carrier protein ThiS sulfurtransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thiamine biosynthesis protein ThiI</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA 4-thiouridine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">thiI</name>
        <name evidence="9" type="ordered locus">FFONT_1171</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + a uridine in tRNA + ATP + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] = [ThiI sulfur-carrier protein]-L-cysteine + a 4-thiouridine in tRNA + AMP + diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24176"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:13337"/>
            <dbReference type="Rhea" id="RHEA-COMP:13338"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:136798"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[sulfur-carrier protein ThiS]-C-terminal Gly-Gly-AMP + AH2 + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH + A + AMP + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:43340"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12910"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:90618"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ThiI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.4" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1171"/>
    <dbReference type="EnsemblBacteria" id="AFH43159">
        <property type="protein sequence ID" value="AFH43159"/>
        <property type="gene ID" value="FFONT_1171"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1171"/>
    <dbReference type="eggNOG" id="arCOG00038">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037952_4_1_2"/>
    <dbReference type="OMA" id="SMPEFCG"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140741">
        <property type="term" value="F:tRNA U4 sulfurtransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01712">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00021">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003720">
        <property type="entry name" value="tRNA_STrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00342">
        <property type="entry name" value="TIGR00342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="8">
        <location>
            <begin position="67"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH43159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="401" mass="44586" checksum="9104B474DA2B73D6" modified="2012-06-13" version="1">MSWKKMDANCIIARFGEIGIKGKITRGRMQSILAKNIENALKSNGFERSIVRVIPGRVLVTTPEDPRKEAELISRVFGVTSSSPALMGEYRDLDDLVDKVSEASIEDVRGKVFMVRGRRADENRFTSKDIERRIGAKLQEMGAGKVNLESPEISIYVEARKGLFFVYKDIINGVGGLPLGSELKILSLVSGGFDSPVAAWMLMKRGSPVDILFFNIGGKEHKEYFLDVAKKLICGWSYGPNQNVYIVEHRWIFPYLFNYFPEGYRTVALKVSMYVGAEALAKSLGIKAISTGENLAQVSSQTVHNLAVTESFIDIPVFRPLIGFDKEEIIELSKKVGTYEVSSRVPEFCAIASSKASTAVDGKKLETFFEKYLPLNEIKQNVLDNVKKIEKKDLCSSGPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2G5</accession>
    <name>I0A2G5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA primase DnaG</fullName>
            <ecNumber evidence="3">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dnaG</name>
        <name evidence="5" type="ordered locus">FFONT_1184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1184"/>
    <dbReference type="EnsemblBacteria" id="AFH43172">
        <property type="protein sequence ID" value="AFH43172"/>
        <property type="gene ID" value="FFONT_1184"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1184"/>
    <dbReference type="eggNOG" id="arCOG04281">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034626_0_0_2"/>
    <dbReference type="OMA" id="KYMIVAQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01029">
        <property type="entry name" value="TOPRIM_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00007">
        <property type="entry name" value="DNA_primase_DnaG_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020607">
        <property type="entry name" value="Primase_DnaG_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034154">
        <property type="entry name" value="TOPRIM_DnaG/twinkle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1 3" id="KW-0271">Exosome</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0639">Primosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Toprim" evidence="4">
        <location>
            <begin position="165"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="410" mass="45673" checksum="E8B0314AC7CC3521" modified="2012-06-13" version="1">MKYLIKAKIEIDGVVDKNDVIGALFGQTEGLLSPDLDLRELQDKGRIGRIAVDLKPQNGKIKGEIKIPSNLDKAETALIAALIETVDKVGPYNAKVQVTRIVDLRIEKLKKAVERAKELLKTWQSAEAPDVKDLLKEIQSSLKPAEIIEYGPEKLPAGSEIEKSDTLIIVEGRADVLNLLRYGYNNAIALEGAKGTIPESVKQLASKKQKVIAFTDGDHAGELILRTLLNNVKIDLVAKTPQGKEVEDLTGKEIEMALQNAVPPQQFLSELEKREEKEEVTQKELEKKEEKLAPQITVTEEQQKPSMPLSIEIPENVMKDMNELKGTLEAILYDDNWNVVARVPVRDLYDTLSKLEANKVKTVVFDGIITQRLIDIASQKNVSYLIGARIGNVLKRDEKVVLLSMYDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2G9</accession>
    <name>I0A2G9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transcriptional regulator, AsnC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1188"/>
    <dbReference type="EnsemblBacteria" id="AFH43176">
        <property type="protein sequence ID" value="AFH43176"/>
        <property type="gene ID" value="FFONT_1188"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1188"/>
    <dbReference type="eggNOG" id="arCOG01580">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091233_5_4_2"/>
    <dbReference type="OMA" id="FVEIYCR"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000485">
        <property type="entry name" value="AsnC-type_HTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019888">
        <property type="entry name" value="Tscrpt_reg_AsnC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019887">
        <property type="entry name" value="Tscrpt_reg_AsnC/Lrp_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01037">
        <property type="entry name" value="AsnC_trans_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00033">
        <property type="entry name" value="HTHASNC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00344">
        <property type="entry name" value="HTH_ASNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50956">
        <property type="entry name" value="HTH_ASNC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH asnC-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="161" mass="18464" checksum="71AC0961FCDAE32A" modified="2012-06-13" version="1">MAKKEKNTIYQLDEIDLKILTHLSNSSKTSLNQLSNILGIPVSTVFARIKKLEEKGIIDKYTLSVDPKKLGFNVTAIINFSVEGSHIEEFEKQISNHPNVLFLYDITGDFDVIAVTRFRNIEELDYFIKNVLKNPYVKRTITNIALRVVKESYPHVPLLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2I5</accession>
    <name>I0A2I5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1204</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="318" mass="35371" checksum="CAAD828D2324D583" modified="2012-06-13" version="1">MSSESKQLKNIFDIPREELFVGGHSMCAGCTAPIIIRHLLKVAGKNTIIVNATGCLEVSTTSFPYTAWKVPWIHVAFENTGAVASGVESAIKAMKMKGILDPNEEINIIAVAGDGGTFDIGFQALSGMLERGHKVMYVLYDNEAYMNTGVQRSGGTPFGAWTTTTPVTKRIRGEWRNKKDIFDIVIAHGVKYAAVANPAYTVDMMNKFKKGLEQEGPSFMHVLMPCTTGWRFDPKYGITIARLATETAIWINYEYDNGKLDVTIPVKKRKPVKEYLKMQGRYAHLNDVEISYIQEQVNKKVEEVNKKVGREVIGPLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2M0</accession>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </evidence>
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    </evidence>
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</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="51" mass="6250" checksum="CAB837E042FBF281" modified="2012-06-13" version="1">MAHYKPLARKLRLSKALKSNSPIPVWVAVKTKRKVRFNFKRRFWRRNKLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="8 9">
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        <lineage>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the archease family.</text>
    </comment>
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    </dbReference>
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        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="51"/>
            <end position="397"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH43313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="466" mass="52370" checksum="9DEC080EF0835130" modified="2012-06-13" version="1">MKEYAKVASYIITVAFTAFATYMLHLSLQQIVSVTVLAIFIAGSFIYWNFRVAFAFLGITLLFVFNVLDIQHFINYSNIDVLTLIIAMMIVVGFLEEYKFFDWLTARIIVNFLDRPMVVIFLLLLLSFIMSSLVNEVASIIFMLAIAVRVCKYYEMNPIPLSIFLVFTTNLGSSATVIGNPIGVLIAFKAGLSFMDFMRWAFPISLLATLVTIAISRYYLEGELKKAKTVKHPEEVKNEIKRMAKFHKKLIVPTIVFFGVILGLALHHYIEEYLRLETNTMLLGMSLLGASASLFIAHDRAIDIVEKKVDWWSILYFLLLFASVGTLEYTHVSDIITSAVMSVTKGNILYIMLILSAVAGAITSVMDNVLAIAIVIPVIDSLKGVINVFPIWWAILFAGTYWGNATLIGSTANIVMAGYMDKLKKRGELERSVGMWEWIKIGVPVSAITFFLAFLLLYLQLGIMPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2W1</accession>
    <name>I0A2W1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Formylmethanofuran dehydrogenase, subunit E region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1330"/>
    <dbReference type="EnsemblBacteria" id="AFH43318">
        <property type="protein sequence ID" value="AFH43318"/>
        <property type="gene ID" value="FFONT_1330"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1330"/>
    <dbReference type="eggNOG" id="arCOG00762">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087508_0_0_2"/>
    <dbReference type="OMA" id="HGHVCPY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026328">
        <property type="entry name" value="FmdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003814">
        <property type="entry name" value="FmdEsu_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02663">
        <property type="entry name" value="FmdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006578">
        <property type="entry name" value="FwdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FmdE" evidence="5">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="DksA C4-type" evidence="4">
        <location>
            <begin position="170"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="225" mass="25415" checksum="D447283A526708FD" modified="2012-06-13" version="1">MVSKTLIEKAREFHGHICPYVVLGLRASEIAMQRLNIKKASEAETVNEDIIAIVECNNCFADGVQVATGCTFGNNGLIYMDTGKNAVTLVRRRDWKGIRVYVDSEKMKKRYFSEEASRLFEKVIARREGTSEDQERLRKLWNEIGFALRDAPEEIFKIEEVKISPVERAPIFETVKCDLCGELVMKTRAKVVNGKTLCQTCAGSCNAVVGRGIVLDFKTPFEKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2W2</accession>
    <name>I0A2W2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleoside-triphosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1331"/>
    <dbReference type="EnsemblBacteria" id="AFH43319">
        <property type="protein sequence ID" value="AFH43319"/>
        <property type="gene ID" value="FFONT_1331"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1331"/>
    <dbReference type="eggNOG" id="arCOG04184">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_1_0_2"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside-triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="174" mass="19787" checksum="8FE29D000C402E9F" modified="2012-06-13" version="1">MEISKILKAYGIHVEHLEREKVEIQAESVEEIALFAGENLFLKEKKPILVDDTGLYIEALNGFPGPYAEYFLKTVGLDGLLELLKNSENRKACFKTAICFCYYDIKKIFVGELCGEIGMEKKGYFGFGYDPVFVPNGYSKTLAEMSIEEKNKISHRGIAARKFAEWFTTETLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2X2</accession>
    <name>I0A2X2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable Brix domain-containing ribosomal biogenesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_1341</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Probably involved in the biogenesis of the ribosome.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1341"/>
    <dbReference type="EnsemblBacteria" id="AFH43329">
        <property type="protein sequence ID" value="AFH43329"/>
        <property type="gene ID" value="FFONT_1341"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1341"/>
    <dbReference type="eggNOG" id="arCOG03247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1323977_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00699">
        <property type="entry name" value="BriX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023548">
        <property type="entry name" value="Brix_dom_Rbsml_bgen_prot"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="3">
        <location>
            <begin position="6"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="207" mass="22977" checksum="C367C8DC2C20D5EA" modified="2012-06-13" version="1">MLNLVNKVIFSTSREPSLRVRSFLKDIISLAPWLVKVNRGKLTFKDLVDITISEKSTTFVIIGEKNGNPSIMRIYDVSDYLIKNAVLHAYTLFIKGVTLAREANRPSSPGYVDDAIIEGSLPPDEEHRNLTFALIKMFGSSIIPNAESSNVLKIQIKGYPNSGWMLNFKKSGSNEYVGPRIFIGKVKKVGEYMSVSESESDGKEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Z5</accession>
    <name>I0A2Z5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cobalamin B12-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="3 10"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0069"/>
    <dbReference type="EnsemblBacteria" id="AFH42063">
        <property type="protein sequence ID" value="AFH42063"/>
        <property type="gene ID" value="FFONT_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0069"/>
    <dbReference type="eggNOG" id="arCOG00786">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1405931_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="11">
        <location>
            <begin position="12"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH42063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="193" mass="22392" checksum="B80CD3EACA31191B" modified="2012-06-13" version="1">MKELKGSISLSLIRNLPYCERMVWFKLNSDIEEPPTPSMILSSERHRDLKRIAESLMLPQPMQFNKKLCHPQIPVCGSPDIISGEERKIIVEYKHFSRERGDFQDFRAQLLTYGWLVQEVEGRVWKLVLMVGREVVWEQEYSYELHISARHLVERLLKILDSPTPPSASYGGKCSYCFFKSVCSSSNQPAEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZB2</accession>
    <name>H9ZZB2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRISPR-associated RAMP protein, Cmr6 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0075"/>
    <dbReference type="EnsemblBacteria" id="AFH42069">
        <property type="protein sequence ID" value="AFH42069"/>
        <property type="gene ID" value="FFONT_0075"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0075"/>
    <dbReference type="eggNOG" id="arCOG02661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053305_3_0_2"/>
    <dbReference type="OMA" id="YFITEVP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010172">
        <property type="entry name" value="CRISPR-assoc_prot_TM1791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005537">
        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39965">
        <property type="entry name" value="PTHR39965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01898">
        <property type="entry name" value="cas_TM1791_cmr6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="301" mass="34186" checksum="3653913F5B928652" modified="2012-06-13" version="1">MRKQGSGFDRSREQEGVEERNMHDILNERFKSLVNRNLYSSIVRSILEYYEVTSEKSGEVELTQFYGKIVKHIQQLKSREKTDLNLVNEYLKDVENGLKEACPRVYSLEIETKSRFIVSMKYPYMPLNLGLAIDPYMNVPFIPASSLRGALRMQLSLNNNDISHNNISLLFGKSEGEEGKHPGILSIFDAYPVKAQNGLFEADVITPHYRESDHKIGKREVDYGIGEHESKPNPILFLTVPSGVTFRAFSAVCDELDEQEKQALTKFVGAFKNFREFPLGLGAKTMTGYGVVEVSFIPIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZB6</accession>
    <name>H9ZZB6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0079"/>
    <dbReference type="EnsemblBacteria" id="AFH42073">
        <property type="protein sequence ID" value="AFH42073"/>
        <property type="gene ID" value="FFONT_0079"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0079"/>
    <dbReference type="eggNOG" id="arCOG02665">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081189_0_0_2"/>
    <dbReference type="OMA" id="IYYIDAD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="341" mass="37469" checksum="01C4168E0D3C465C" modified="2012-06-13" version="1">MILRIKPITNPIFSRRPFSSPDYIASHSVWEIPPPTTVAGTLGDALGITIPTNESSKLLGLDKLSEKLNEKLTEPCGIPFSITGPLLETEGRYFVPIGEGVFLPVQYDNVKKIAVIGDQNKAKLIHGTERRVGVSLKRGYNQSEEKVGRSGMHYRYLVSVYEMVENEKKRPVLPNYVYKLTGCQGSGNIQQKRAIRFGGEGGIAFLEINRSKEEDSIFSAMFSPLSNLEQGCYLALSPIPLIPKHGNSSHISEVTGLEPFGGPSSVRGICDERSCKVKVVRMGLGFSEVYKSRRPQILALPQGTLLEVSDKHGSNNSKVLKVLYSLGFASLLKVGDELCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZF4</accession>
    <name>H9ZZF4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like (HAD) hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0119"/>
    <dbReference type="EnsemblBacteria" id="AFH42111">
        <property type="protein sequence ID" value="AFH42111"/>
        <property type="gene ID" value="FFONT_0119"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0119"/>
    <dbReference type="eggNOG" id="arCOG02292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104492_0_0_2"/>
    <dbReference type="OMA" id="DFYEAYS"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="212" mass="24594" checksum="51FFA9DB200A06A5" modified="2012-06-13" version="1">MQKTLYILDLDMTLIDSLKVFYRVYSQLLKKYFNEDISFEDFYEKFCTNSLDNYKNYPKDFWKDFKEMYYAKDRSEIKPIDGAEELLRFLNERGIVVVLSGRGVDGDEVLKELEYFSLSKYVSEVYTLKIYDSDKPFLKDDAVRKIINNHRGFSKCILVGDYVDDVSAGPKNGCISIGITINGCKSGEELLRAGADYVVEDLFELKSILEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZG5</accession>
    <name>H9ZZG5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HhH-GPD family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0130"/>
    <dbReference type="EnsemblBacteria" id="AFH42122">
        <property type="protein sequence ID" value="AFH42122"/>
        <property type="gene ID" value="FFONT_0130"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0130"/>
    <dbReference type="eggNOG" id="arCOG00459">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_4_2"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="7">
        <location>
            <begin position="49"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="225" mass="26485" checksum="BDF5D2306D7E021F" modified="2012-06-13" version="1">MQKDTNDFLREKINKALRDLNLEKGQRFIVKEVSKNFDDPFYLLISIILSQNTTDRNAIEAFLNLVERGLDFRKLNSMSLGELEEIIRISGLYKSKAETIKRLAGFLSKDELFLKNLCKKPPEEARRELTSIKGIGKKTADLFLSVYCNMPLFPVDRHIKRVTERLLDKKMDYEEVSQFWREVLDRNLLKEAHYKLIYVGRKFCRPKGEKCDLCPLADICRWRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZJ3</accession>
    <name>H9ZZJ3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0158"/>
    <dbReference type="EnsemblBacteria" id="AFH42150">
        <property type="protein sequence ID" value="AFH42150"/>
        <property type="gene ID" value="FFONT_0158"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0158"/>
    <dbReference type="eggNOG" id="arCOG00585">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024839_0_1_2"/>
    <dbReference type="OMA" id="QHITFKD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="PTHR42961"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="55"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="300" mass="33304" checksum="74EC832E41C7C867" modified="2012-06-13" version="1">MSESRSGKNDLRIREMKAGSTTTNPKKAAEEIDQYISMMQKKFEKIKNRIMIFSGKGGVGKTFIAASIAMYLSKMGYKVGVYDADETGSVIPFVLGNSDAEIYMEESSGELIPANIKGIQVMSLELMLKEKDSPLIWQGALRTKFILQTLALTRWEDLDFLIFDMPPGTGDEAITISQYVPSPKYAIIVSSPGKLSEGVVRKAVVFLKKMEIPILGIVENMSHYTCDDGSKIEVFGKSYIEEIARDHGIEALGKIPLDERIRESQDKGVPIYELASGSEIDRSLELLAKKIIEKLSSKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZJ9</accession>
    <name>H9ZZJ9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_0164"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:L-lysine efflux transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="LysO"/>
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    </dbReference>
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        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="198" mass="21724" checksum="8269AF3456A971AB" modified="2012-06-13" version="1">MMKFYQAVILAFIAGFIAGKLFRPENVSLLMENSFLVMLVFFASIEASLRIREIKSFRKAFLGVRTLLFGILGSLITGLLFFFVLGKGSIPACMGLGWYTFTGPYLSALGGSTLGTIGFFSNLSRELFGIIAFPSIQKYFGDFGAVTYAGDPVYDVLFPFVLKYCKSEDSVIAAFVQGFLTGFVVPIIVPLSFILVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZK3</accession>
    <name>H9ZZK3_FERFK</name>
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        <recommendedName>
            <fullName evidence="1">UPF0273 protein FFONT_0168</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0168</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0273 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0168"/>
    <dbReference type="EnsemblBacteria" id="AFH42160">
        <property type="protein sequence ID" value="AFH42160"/>
        <property type="gene ID" value="FFONT_0168"/>
    </dbReference>
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    <dbReference type="OMA" id="FSQQFLW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
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        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="thermo_KaiC_1"/>
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    </dbReference>
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        <property type="entry name" value="KAIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="2">
        <location>
            <begin position="6"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="247" mass="27475" checksum="DE6EB8F2D856B289" modified="2012-06-13" version="1">MSFTIERVKTWIPGLDELLNGGIPKRNVVIITGGPGTGKTILSQHFLYNGLVRGEASVYVSLEEHPVQVRRAMATFGWDVKKFEEEGKFAIVDAFTSGIGEAAKREKYVVKSVDDVGELIDVIRMAIKETNAQRVVIDSVSTLYMTKPAIARNTVMQLKRILSGLGTTSFLISQVSVTERGFGGPGVEHAADGIIRLDLDEYDGQLLRSIIVWKMRGTAHDMRRHPFDITDKGIIIYHDKVFKSHVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZL8</accession>
    <name>H9ZZL8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcriptional regulator MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42175">
        <property type="protein sequence ID" value="AFH42175"/>
        <property type="gene ID" value="FFONT_0184"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0184"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053800_0_0_2"/>
    <dbReference type="OMA" id="AIAIWEP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
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    <dbReference type="Gene3D" id="1.10.10.10">
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    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="335" mass="38430" checksum="0CE1FDF93B852CEF" modified="2012-06-13" version="1">MSKGELKEKILELLANFQGESIPQSYIHRSISASKSRVSEILYELEREGLIKRKQIGRSKFIYAYTGIKEKAHEKDEMRMTIGIVYSSEYLFLGYFLKKMNEMKHKVNVKVFSDGLEALDALVHGRIDLAISPFIGQLIFSTIYESYKILPRGMGRGYEILYLDGGNKVHSSKLSTMDYIRSLSIKNGIIDAENTVYYSSPDELLYMAKKEKGYVITWHPLYKKVESMGFKVVKDAGIMENELCCSLAISNIVAESVREKITWMYRESLEAYSKDRSRYLELYSIITGIDIDLIKDAMYVYEPFNGDSMKATEEVLDIISPSVPDKSVYLKSIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZM2</accession>
    <name>H9ZZM2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A reductase</fullName>
            <shortName evidence="3">HMG-CoA reductase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0188</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HMG-CoA reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0188"/>
    <dbReference type="EnsemblBacteria" id="AFH42179">
        <property type="protein sequence ID" value="AFH42179"/>
        <property type="gene ID" value="FFONT_0188"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0188"/>
    <dbReference type="eggNOG" id="arCOG04260">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033422_0_0_2"/>
    <dbReference type="OMA" id="GHMKMHL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004420">
        <property type="term" value="F:hydroxymethylglutaryl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015936">
        <property type="term" value="P:coenzyme A metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00644">
        <property type="entry name" value="HMG-CoA_reductase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.770.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002202">
        <property type="entry name" value="HMG_CoA_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004553">
        <property type="entry name" value="HMG_CoA_Rdtase_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023074">
        <property type="entry name" value="HMG_CoA_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023076">
        <property type="entry name" value="HMG_CoA_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009023">
        <property type="entry name" value="HMG_CoA_Rdtase_NAD(P)-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009029">
        <property type="entry name" value="HMG_CoA_Rdtase_sub-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10572">
        <property type="entry name" value="PTHR10572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00368">
        <property type="entry name" value="HMG-CoA_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00071">
        <property type="entry name" value="HMGCOARDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55035">
        <property type="entry name" value="SSF55035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56542">
        <property type="entry name" value="SSF56542"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00532">
        <property type="entry name" value="HMG_CoA_R_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00066">
        <property type="entry name" value="HMG_COA_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01192">
        <property type="entry name" value="HMG_COA_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="427" mass="46813" checksum="63F8F5D6D85C3092" modified="2012-06-13" version="1">MEKMGEKSSRIQDFHKMSFEEKLKIVKEFSNLSDEEVNLLKSMGSLDRKIAETMVENVVGVMPLPFSVAPNFRINGRDYLIPMVIEEASVVAAASNAARFMRDGNGIISIATDSIMIGQIYIYGVKNISFASQIIYENKDEILKLANETDKYLVNIGGGAKDVEVRAIDTRNYGKVLCVHLLVDVKDAMGANTVNTMAEKVAPFIEKLTEGRAILRILSNLADRRIVRTRAIVKKEMLGEEAVELIAMASEIAASDPYRAATHNKGIMNGVIAVALATGQDHRAIEAGAHSYAARTGRYTTLSFWEKDREGNLVGTLEMPLAVGIVGGSIKVHPITKIALKILNISTAKQLAEIMGAVGLAQNFAALRALTTEGIQKGHMRLHAKNIAVMAGASYEEAEKIAEIMVNEKNISFYRAKEILEDIRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZQ4</accession>
    <name>H9ZZQ4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0220"/>
    <dbReference type="EnsemblBacteria" id="AFH42211">
        <property type="protein sequence ID" value="AFH42211"/>
        <property type="gene ID" value="FFONT_0220"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0220"/>
    <dbReference type="eggNOG" id="arCOG02441">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_527494_0_0_2"/>
    <dbReference type="OMA" id="RTTIIMI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032688">
        <property type="entry name" value="ABC2_membrane_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12679">
        <property type="entry name" value="ABC2_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="511" mass="55293" checksum="ED0733D86B511D0C" modified="2012-06-13" version="1">MGALLYDFKRSFLRPATLIALIVFILAGIGLSYMLSATLSMSSGTVSFDGYGSLNISSSVLNVQLYAYDADLNPARGTVNVTLSLVNLTQQANSPRTPYSSILVKSETFPISGYGNYSISLGTQDISMLNTSGLTPVLEIDLSTNIGSLMYLSTFNERGGNLYWCTSCLTFSGINNTEKIYGSGSVYSNENLSKAFLILDLPSGGYSLYYELVNSTILSSLSQINLSSAKYIGNVSPGANIFSLSENLSNQSLALLVMKDPQGNEYYSTIPVEQYTPGSVQRTVTSLALGASGISLFAEFFPIIVLYIVYALIAKPRGMGALEFLLARPVTRWDIYYTRYAAGVLTTITSTAVFFTSFVLGSIALIGYTLRAGQMVLLFLGVTGALVAFYSLCYFISTVASSGRYLALSVFLYIFFTIILSIIASVVAFELYGTSGNLFDMLQKLRYELDYFSPLGLTEFASYFVSRSLSLAPSVASSVINPALVIASGILWIAVPFVAGWFIFKKANLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZQ9</accession>
    <name>H9ZZQ9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dihydrodipicolinate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0225"/>
    <dbReference type="EnsemblBacteria" id="AFH42216">
        <property type="protein sequence ID" value="AFH42216"/>
        <property type="gene ID" value="FFONT_0225"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0225"/>
    <dbReference type="eggNOG" id="arCOG04172">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_5_1_2"/>
    <dbReference type="OMA" id="YYGYGGF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008675">
        <property type="term" value="F:2-dehydro-3-deoxy-phosphogluconate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="301" mass="33654" checksum="425BF02DF6A918FB" modified="2012-06-13" version="1">MRPKFYGVITPFITPFKEDLSLDLDSARWLARYQAEGGVHGIFPNSTTGEFVHLSKEEAVKLTGTVLEEVGGKVWIIPGISANSTEDSISLGRIFKNMGVSGTIITPPFFFKVSGERLKLHFSMVAERVDLPIIIYNIPSATGINIPISLYRELSEEYSNIVGAKVTYENFTYLRGLIQEVKSVREDFSILVGFDDMLLPNLMMGGDGGIMALANAAPKIHRNVYDFWREGSFEKALEWWKKLLELTKVYDISTSFPTAVKTLLSVMGSPVKPYVRPPLTPERDEVVQKVRKIAESLGLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZT4</accession>
    <name>H9ZZT4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ATP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0250"/>
    <dbReference type="EnsemblBacteria" id="AFH42241">
        <property type="protein sequence ID" value="AFH42241"/>
        <property type="gene ID" value="FFONT_0250"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0250"/>
    <dbReference type="eggNOG" id="arCOG01225">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037460_3_0_2"/>
    <dbReference type="OMA" id="CFEYLLQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="PTHR21231"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="256" mass="28668" checksum="A772AAEE1953611A" modified="2012-06-13" version="1">MECKYVVFMGPAGSGKTTLTATFSDWLSSQGIDNVKVNLDPAVEYLPYDPDIDVRNYVDAREVAKKYSLGPNGALLASMDLLYGKLEDIKKELMEIEGEYVLIDMPGQLELFSFRSTGPLIVDRLSSKNRTAVVFLMDANFTASVENFLSILMLSHSIRIRHYFPQINAISKIDLLSPELLEELLTLKESPELLKEKVIDKGDPKYHDYINSIADFLIEEGIDFIPVSSTTGEGLDELFASIQNLISNLDEIETNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZT8</accession>
    <name>H9ZZT8_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0254"/>
    <dbReference type="EnsemblBacteria" id="AFH42245">
        <property type="protein sequence ID" value="AFH42245"/>
        <property type="gene ID" value="FFONT_0254"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0254"/>
    <dbReference type="eggNOG" id="arCOG02579">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1465075_0_0_2"/>
    <dbReference type="OMA" id="PARPMRC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="186" mass="21654" checksum="BA63725DB0B2CA1A" modified="2012-06-13" version="1">MNYIRVGEKFKFKCTRCTLCCGTGPNVSITVFDVIRMSKYLDVNPIQFLKIFTNVIIADLIPVIALKGDIAGRCEFLGFDSNGKTFCKIYKYRPLKCRLYPVKLISPKSNHVYLDTDCPGLYAEDAEFIDFPVDIYKRNAYEVEWQYKKLYEKIFNEGKEPLNALLELIEELYEEAKNKNPSWLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZV1</accession>
    <name>H9ZZV1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0268"/>
    <dbReference type="EnsemblBacteria" id="AFH42258">
        <property type="protein sequence ID" value="AFH42258"/>
        <property type="gene ID" value="FFONT_0268"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0268"/>
    <dbReference type="HOGENOM" id="CLU_3162951_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="47" mass="5649" checksum="F02EE60E98997D24" modified="2012-06-13" version="1">MISRVELLCEGKRALPESSDKKIVEFLWMLRDKIYRALRCFRILLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZV6</accession>
    <name>H9ZZV6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase nickel incorporation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0273"/>
    <dbReference type="EnsemblBacteria" id="AFH42263">
        <property type="protein sequence ID" value="AFH42263"/>
        <property type="gene ID" value="FFONT_0273"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0273"/>
    <dbReference type="eggNOG" id="arCOG04426">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126929_2_0_2"/>
    <dbReference type="OMA" id="EREMIHF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="127" mass="14617" checksum="61D3EF2671456C7D" modified="2012-06-13" version="1">MNMHEIAIAQGIIEAIKEKAFHEKISEVKVLFGELQNIDINIVMNYVTMTLESLNIKVKLSYEIREARFKCNKCGYEWSLSDVSLSEDEREMIHFMPEAVHTVVSCPNCKSSDFEVLDGKNVMMLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZW4</accession>
    <name>H9ZZW4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxidoreductase FAD/NAD(P)-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="5">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0281"/>
    <dbReference type="EnsemblBacteria" id="AFH42271">
        <property type="protein sequence ID" value="AFH42271"/>
        <property type="gene ID" value="FFONT_0281"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0281"/>
    <dbReference type="eggNOG" id="arCOG02199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_1_2"/>
    <dbReference type="OMA" id="RYMKCGI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
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        <location>
            <begin position="229"/>
            <end position="259"/>
        </location>
    </feature>
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        <location>
            <begin position="85"/>
            <end position="86"/>
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        </ligand>
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        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
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        </ligand>
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        <location>
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        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="238"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
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        <ligand>
            <name>[2Fe-2S] cluster</name>
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        <source>
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        <source>
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        <source>
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        </source>
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        <source>
            <dbReference type="Pfam" id="PF10418"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42271.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="268" mass="30273" checksum="546C11E011E8ED32" modified="2012-06-13" version="1">MQNLRGIGKMEKKKFEIKPVKIERNEEVAENTFLISFLPLEDLSLEVKPFNFFMVWIPRIDFIPLSVSDYDGNSLTFLYKIKGNGTKALSLKKKNEILGIMGPLGKEFFFKNGEKILVVAGGIGIAPIPYFVKFSKGSEIDLVWGVKKGSELFEVTKIYGKMNNLKNFIIYTEDCSYGKCGKALDALREIRLNEYNRILSVGPEVMMKNFCNLCNKKNDCYVALENLTKCGMGICGSCYIKGTTKLMCSDGPVFECSEVKYHFESIIA</sequence>
</entry>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
            <begin position="4"/>
            <end position="214"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="229" mass="25027" checksum="82686D6565027074" modified="2012-06-13" version="1">MVKIIIIALDPPPNVDEVEWIENRFYELNGLVSGFKIGLPAVLKNGLESYKRIFKDYKGLLIADFKLADIGDIMSMSAEIIKSYGFNAMIAHSFVGYSNAIDKLSKKAKDLGLKLILVVSMSHEGSKEYIDGHLNDFLQIAVKANAWGVVAPATRVDVIRNVRSKVGKDIKILSPGVGAQGADFGSAICNGADYEIIGRSITGAENIKEKATQIIKTIEERVKICRGLQ</sequence>
</entry>
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    <accession>H9ZZX5</accession>
    <name>H9ZZX5_FERFK</name>
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        <submittedName>
            <fullName evidence="3">Putative RNA-binding protein, eukaryotic snRNP-like protein</fullName>
        </submittedName>
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        <name evidence="3" type="ordered locus">FFONT_0292</name>
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    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42282">
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        <property type="gene ID" value="FFONT_0292"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG01695">
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    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT-R_1" evidence="2">
        <location>
            <begin position="425"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="371"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="629" mass="72809" checksum="7ED27CE789192452" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZY9</accession>
    <name>H9ZZY9_FERFK</name>
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        <submittedName>
            <fullName evidence="4">Serine protease-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ordered locus">FFONT_0306</name>
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    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    <reference evidence="5" key="1">
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0306"/>
    <dbReference type="EnsemblBacteria" id="AFH42296">
        <property type="protein sequence ID" value="AFH42296"/>
        <property type="gene ID" value="FFONT_0306"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0306"/>
    <dbReference type="eggNOG" id="arCOG01937">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453895_0_0_2"/>
    <dbReference type="OMA" id="VMMTGMI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
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</entry>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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    </evidence>
    <sequence length="145" mass="16400" checksum="2D54D03A6309FB92" modified="2012-06-13" version="1">MTSKLTWGSIVIADLDNFEEVVREKGLNEYVKNSITNALTEGVIFLAIKFRGIIIYGVNKERGTEEAVLEFPMMRCSDLESDLYSIKEEINKNGANITVVCLEGYVLGKNANSRKEAYYGTPWRSFARKILEEAKRKGGNRIIII</sequence>
</entry>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Perevalova A.A."/>
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</entry>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42332">
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="54" mass="6371" checksum="25CF3465F5ED8722" modified="2012-06-13" version="1">MEYSIETEKFTDGTKRIKSFYKCPVCNYKVNDQQISVSKVDGTEKLIIKIEKFF</sequence>
</entry>
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    <name>I0A029_FERFK</name>
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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                <person name="Mardanov A.V."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
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    </evidence>
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    </evidence>
    <sequence length="452" mass="50496" checksum="1E48A663A65B7D62" modified="2012-06-13" version="1">MKYHPWIPNDNEELLNIMLKTIGINNWDELFTSIPEEIKLKKKLKIGAERPLNTIELEKHMKEVVRAQNIVDLERVFSGGPVAPHFVPQVTTYLINRGEFLTAYTPYQAEISQGLLKALYEYQSLMAILYDIEIVNAGMYDGGTALAEASLLSIRIKKNKKIAISSTLFEEYKSVIKTYLYGQNATLIEYDFDKDTGEITGETIEKIKNEKPSGVIIDYPSNFGPIRKSTKELIEEVHKYGSLAITFSDPSSLPILTPPGELGSDIIVGEGQSLGLPMSGGGSLLGILGIKNDKELLRNLPGRLIGETVDADGKKGYMMILQTREQHIRREKATSNITTATTLNAIAVAINVLLYGEKGLKTRAEKILENTKMLKQALEKNGIEASYKKALHFKNISYKIDDPFTEGREIIEKYKIIPFTPYQNYAISSATEVHNNEDISLFSEAIGGVLRK</sequence>
</entry>
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    <accession>I0A065</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
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            <dbReference type="EMBL" id="AFH42372.1"/>
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    <evidence type="ECO:0000313" key="2">
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    <sequence length="49" mass="5935" checksum="F25D2B299FCE86E3" modified="2012-06-13" version="1">MSFRQAKWNEPIAFDIEHQNRSSLEFEVDEKLELPSELKKKRAKNSWNE</sequence>
</entry>
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                <person name="Ravin N.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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            <end position="212"/>
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            <end position="291"/>
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        </source>
    </evidence>
    <sequence length="291" mass="32531" checksum="CFFD1B2C06ACC80A" modified="2012-06-13" version="1">MRKKIIVLAFIIIFIYSITFISIAQEPSYTNAVISIDSYGIASIKQVIPVNDVSVVNCIGNCLYVLNINTSNVDYYLENNTIVLVPNNFTGNVLLEYISQLAYPNGTIWNVSFSSDINTTVVLPYGAILLSTNPLPIDFNVTSDGRLYFVYMPGNITLSYSYLQSANITNTTGFTSTTPSTAGLHQGISNYALYIIGIILIAIGLLIGYLYFRGPKKGKSLEEKIKYLDDRDRKIVEIIREKGPITPGDLLNQLNIPRSAFYRRINRLKKDGIIEQFEVGGKVYYKLKEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0C9</accession>
    <name>I0A0C9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S6e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps6e</name>
        <name evidence="5" type="ordered locus">FFONT_0446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0446"/>
    <dbReference type="EnsemblBacteria" id="AFH42436">
        <property type="protein sequence ID" value="AFH42436"/>
        <property type="gene ID" value="FFONT_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0446"/>
    <dbReference type="eggNOG" id="arCOG01946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275302_0_0_2"/>
    <dbReference type="OMA" id="FRARAWQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00512">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_S6e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020924">
        <property type="entry name" value="Ribosomal_S6e_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="PTHR11502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="223" mass="24664" checksum="556ADE986A14A38F" modified="2012-06-13" version="1">MKKELDAEVNEVMPEFKLVVSVPKHNNQSIKVKVVGDEKIQLSKEQKEGRKLPIAIVSRALADKLNVNDAVLMLKFSQEGGKVIKMHFKTTIEDGLDENTVKISSDLLGEKIGELQAEAIAMKSKAFQLTLDDSTSRRFVGMKIGDEIDAVIIDLKGKLVVKGGSDNSGFPMRKDLPGAVKKKLLLSGPPGYHPERNGEKRRKMVRGNTIDESFVQINTILVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0D3</accession>
    <name>I0A0D3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">30S ribosomal protein S28e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps28e</name>
        <name evidence="4" type="ordered locus">FFONT_0450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0450"/>
    <dbReference type="EnsemblBacteria" id="AFH42440">
        <property type="protein sequence ID" value="AFH42440"/>
        <property type="gene ID" value="FFONT_0450"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0450"/>
    <dbReference type="eggNOG" id="arCOG04314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178987_2_0_2"/>
    <dbReference type="OMA" id="MHGEASQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_S28e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_S28e_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="PTHR10769"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="79" mass="8986" checksum="20A272F361BF2FAB" modified="2012-06-13" version="1">MSLKEERSAIIEEFGYPAEVIQIIGRTGVTGEIIQVRVRVLEGRDKGRVLTRNVKGPVRIGDILILRETEREARRLSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0D6</accession>
    <name>I0A0D6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0453"/>
    <dbReference type="EnsemblBacteria" id="AFH42443">
        <property type="protein sequence ID" value="AFH42443"/>
        <property type="gene ID" value="FFONT_0453"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0453"/>
    <dbReference type="eggNOG" id="arCOG01724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1782442_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019217">
        <property type="entry name" value="DUF2118"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09891">
        <property type="entry name" value="DUF2118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="145" mass="16923" checksum="2AEB6B9D7F083099" modified="2012-06-13" version="1">MVNICYRLEDDKKIPSVKNYLKSNENIESKLDISLDRIACEEIIFNNISFGERNICVSKGNFIIKTPKNSFLIERNEELKYFIIEASQINTRKKPGDSVKKWDEIAVSKSKKGILRRIKIPFEGQIILVEQDPTYKPERIVFILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0F0</accession>
    <name>I0A0F0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps13</name>
        <name evidence="6" type="ordered locus">FFONT_0467</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0467"/>
    <dbReference type="EnsemblBacteria" id="AFH42457">
        <property type="protein sequence ID" value="AFH42457"/>
        <property type="gene ID" value="FFONT_0467"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0467"/>
    <dbReference type="eggNOG" id="arCOG01722">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_0_0_2"/>
    <dbReference type="OMA" id="IRAYRGI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019977">
        <property type="entry name" value="Ribosomal_S13_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03629">
        <property type="entry name" value="uS13_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="164" mass="18385" checksum="7CEEB81FD34233AE" modified="2012-06-13" version="1">MAEEAGQFRYIVRVAGTDLDGRKKLAYGLAGIKGIGYTTAVCLLRMLNIDPEKRTGFLSDEEISRIEKAISEISASNLLPKWMLNRRKDYETGDDIHLIGSELIFKVKQDIEREKKIKSWRGIRHSLGLKVRGQRTHTTGRLGVTVGVSKKKTAAKPQSSEQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0F4</accession>
    <name>I0A0F4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na+ symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0471</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0471"/>
    <dbReference type="EnsemblBacteria" id="AFH42461">
        <property type="protein sequence ID" value="AFH42461"/>
        <property type="gene ID" value="FFONT_0471"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0471"/>
    <dbReference type="eggNOG" id="arCOG01316">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_15_0_2"/>
    <dbReference type="OMA" id="IYSIGTM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="451"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="496" mass="54366" checksum="8B6E65734E5C2321" modified="2012-06-13" version="1">MEFSTFDIALFFLIVASTIIVAFLGARWRAADMSKISEWSIGGRKFGTLIVWFLMGGDIYTAYALISVPGGAYGQGGFILYSAVYGAMAYPFLYYVAPRLYLIAKKKGMITGGDYVRERFKSDTLSLLISLTGIIAMLPYIALQIVGIKYVLQAMNFPIVESYIIAFLIVAAFTVVAGLRGPALGAIIKDILLWAVIITITVVLAIRFDGFSLVFKSLDAQGLNYMIPPNLMIGYMTLAFGNGIAWLLFPNLLTGILGSKDAKTIKKNSVLLPVYQVWMLILAIFGLVALSENLVPNKVSSLAFPSVLTTYFSPTFVSIAFAAIIIGAMIPASLQALSAANLITRNIYLQYINKQASERKQVLVGRISVFIMIVASLIFVLTPAASGLIFYLLTMSYAWLLQTLPAIILSMYWHSLDKYSVAAGWAVGVTFTTYGLYTVKFASSLLPWFKYAYVGLVGLALNLVVLLAVYAIVRMAKIKYESGIAPEEFTDYDVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0G0</accession>
    <name>I0A0G0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0477"/>
    <dbReference type="EnsemblBacteria" id="AFH42467">
        <property type="protein sequence ID" value="AFH42467"/>
        <property type="gene ID" value="FFONT_0477"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0477"/>
    <dbReference type="eggNOG" id="arCOG01943">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_8_4_2"/>
    <dbReference type="OMA" id="ICGTLAN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008908">
        <property type="term" value="F:isochorismatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016291">
        <property type="entry name" value="Isochorismatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01398">
        <property type="entry name" value="ISCHRISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="185" mass="21079" checksum="8D19B15EA4257075" modified="2012-06-13" version="1">MKFSLIIIDMIHDFVDGKFGNENVKKIIPCIRELKEFAKKNSIPVIYAVDSHIKGVDREIEVWGEHAIEGEWGSKIIEELEPQNGEFIIKKRRYSAFFSTGLDLLLRELDVDTLILTGTSTHICVLHTAADAFFRGYKIIIPKECVAAFSESDHGYALVYMSQVYGAKVLSKDEIKRIIEENQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0G7</accession>
    <name>I0A0G7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent FMN reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <end position="160"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <dbReference type="EMBL" id="AFH42493.1"/>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="129" mass="15206" checksum="36081658073EE4F8" modified="2012-06-13" version="1">MSKEMKKLLLKLKKSKPEFKRHLFHMFIKFRNQDSWRKPKGIDNKMRLKYKGYAKPVEIGYKNPEIVRGVHPSGLRPVVIESRSQLENLDPKIHIVYLSSKLGLKKKIELMKLAREKGLRIANEVKVIE</sequence>
</entry>
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    <accession>I0A0J7</accession>
    <name>I0A0J7_FERFK</name>
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        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S3</fullName>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    <comment type="function">
        <text evidence="5">Binds the lower part of the 30S subunit head.</text>
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        <text evidence="5">Part of the 30S ribosomal subunit.</text>
    </comment>
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        <location>
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            <end position="87"/>
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    <evidence type="ECO:0000259" key="8">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
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    <name>I0A0M9_FERFK</name>
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        <submittedName>
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        </submittedName>
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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    </evidence>
    <sequence length="91" mass="10583" checksum="1C71D1BC0241AA77" modified="2012-06-13" version="1">MNISVLKRNGEKEEFMPEKIIVSLVKTGATPEVARKIAKIIEGRLLERGVSEIATKDLMKEVLELLKKENEEWYNNWLVFDRAVKKRKIEA</sequence>
</entry>
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    <accession>I0A0V8</accession>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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            <dbReference type="Pfam" id="PF00535"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="351" mass="40129" checksum="554788833BEBDDB3" modified="2012-06-13" version="1">MITMCEKEASTCVSIVLTTYNDEDTISAVLNSIYTLGLDLNHIELIIVDGGSTDKTLSIINDFLSNNAIYFKRNLLIVHDKNYGISRARNDGIREARCPYVLILDSDIVLPSNALETMLQYLISERKTKKVVGVKPLIDTAPFIFKVIAQGKIHRKNLGACEAFLASTEILMKNMYDETMGPPHSSDEDIELGARLLKQGLEIHMLGFITAHHIKSPQSLYVTTTRSKKKYLIKILKIIRSYYTPYVKYGFKRYFKSLPILIKFSYILDMITYMTMIMIIALSVITISWHTQFSYCSGLLSIMFTSSIISSLIIKIIFELKGLFDYRTLHYIVLYAFLQSINRFLRMLSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0X1</accession>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="204"/>
            <end position="344"/>
        </location>
    </feature>
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            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="381" mass="44084" checksum="967A3E0917209283" modified="2012-06-13" version="1">MKIAVIHDSLNNGGGAERLAVYMAKTLSESGYDVYLVTMEKTNWLRLRGIMGDDVESYFKGEVIIPYLKLPLSLYDRFNAWLIRDIVAFSLKVRSRYDLTIVTKQYGIPILADIAYIHFPDFYPGVESLYYPERYVKNTFLRIYSMPYRLILKALLELYKVIDYRPLILTNSSFSKAVIERWLRTPAIVLYPPVNVEKYLKYSSNKQRDNLVVSIGRIERAKGLHVIPYVAKETSGIKYAIVGLVSDHKYLAEINELIKKLNVEDKVKILNNLNEDKKLKILSRAKVYFHPMKYEHFGISIIEAMAAGLVPVVNRMSGSWSDIIKFGKYGLGCDGQDDCANMITYAVNKYDQLSKIATMRVRYFNYERFKDNLTRILKKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0X3</accession>
    <name>I0A0X3_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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    </gene>
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        <lineage>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42630">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="327" mass="37331" checksum="DDC56A356CF9795E" modified="2012-06-13" version="1">MLFFSPEYKYWYGTQDVERKYPFPAIMLAIVKIVTDIPLGTLPLLPLPGIVIVIIFYLILKLAVREFKNILNKFVLISFLTMYLAVFTLLGLHAFYVGRATLGVALVMLYVFVLIKLHVFKGIEVPSVVALIFLMLASTFTYYTTSLAVFVLPTTLLMSGLISKNSKGYNSNINMNVLKTLAIIGLILIYFQPIVSSLVKSASPSTFFYNLYKFVLAQLKFEKESEAYLLNVGYVEIDLFTRITGVWFSYFIRIAIVVIVTYTFMYLYAISTIADYENDRMGDRRHSNRWLGSRTAIYLTCAYSIVKVCNNIWSATTPVNCRKRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Y0</accession>
    <name>I0A0Y0_FERFK</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0647"/>
    <dbReference type="EnsemblBacteria" id="AFH42637">
        <property type="protein sequence ID" value="AFH42637"/>
        <property type="gene ID" value="FFONT_0647"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0647"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="198" mass="23031" checksum="79697303D27EDC58" modified="2012-06-13" version="1">MLNKILPYAHRPHEIEAYSRQRRLSELIKHYLGKSGKLIMRVLRTLKNNVELEHPQWFSTQSIDTRDEFSAGSLFETLENFGVNEVVVDPDLSKEPGEAQIYVLTDKGVAIKYLGREDPQRDIYIPLKPVSIRLPRGKYQIKHVKASYDFLESTRRSKDQDVEYNVLKPAEVESYIINNTCRFKQKAIRAKDLISLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Y5</accession>
    <name>I0A0Y5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PstS family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH42642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42642">
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        <property type="gene ID" value="FFONT_0652"/>
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        <property type="taxonomic scope" value="Archaea"/>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
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        <property type="entry name" value="ABC_phos-bd_PstS"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="6">
        <location>
            <begin position="66"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="31"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
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    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="400" mass="42965" checksum="96CDF9B02127B0BF" modified="2012-06-13" version="1">MKERAISYLAVTVIIAVLVLASVGAYLALSKGSSSTPTSTPSQTSTPSQTTSAPIQTTTQKPPATTTTSQLSVTLKAGGATFPLPQYIAWINEFMKNYPNIKISYEGVGSGAGQSNFFAGVFDFAGSDPPLSKSQWSNYTGRVMQIPIVAGAIVIVYNVPNLNGQLKVTPEILAMIYNGTIEYWDDPAIRQVNPNLNLPHQKIFVVFRSDASGTQEIFTTYLNVAAPQYWPTSLVGKAPDYPVKATGRAAGGQGNPGVAAILNQTPYSIGFVEWNYAIQQNMTMALLRNANGNYVLPTTQGIIEALNSAGGSIPLDPFADFSQDIKAFLNLPGNDSYPIIAATHLLVWGKYQNKDIAKGIATFLEWILKYGDNYIVPGYAPVGSTLKQIGYKAVDVLNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Y8</accession>
    <name>I0A0Y8_FERFK</name>
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        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0655"/>
    <dbReference type="EnsemblBacteria" id="AFH42645">
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        <property type="gene ID" value="FFONT_0655"/>
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    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
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    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Phosp_transpt1"/>
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        <location>
            <begin position="5"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="256" mass="29163" checksum="0BE757529A172E43" modified="2012-06-13" version="1">MREVIRTERLSFWYGSKKVLHDVELSIMENSITAILGHSGSGKSTLLKVFNRMTDLIPGARMSGKVEVFGKDVREWDPYELRRRMGMLFQIPNPFPHLSIYDNVAIAAQVSRNIKDKKEIQATVEWALRAAALWDDVEDRLDDFPYKLSGGQQQRLCLARALAMKPEILLLDEPTANIDFENTIIIENALKDIAKSSGITIVIVTHLPDQAVRVSNYMIIMNRGVVVEGGKTEEIVRNPKEKFTKLLFNGFFREKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A114</accession>
    <name>I0A114_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0683</name>
    </gene>
    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_0683"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016740">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
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    </dbReference>
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        <property type="entry name" value="SSF53448"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="309" mass="35031" checksum="6DAC2B02D6C94060" modified="2012-06-13" version="1">METCVVITTYKRAWALPYSIASLKDQSIPPSKVVFVLKPSGDESEKVIEECAEGLNYEIVIQNEGNVAMAVELGIKACKEHDLILFLDDDALASKNWIEKYTEFFERNKSAGGASGIVYKAVLEDNKVSLIDEPFYGKENYTVRSGIHRRPLPEYKDYCEWLSTSGLIGTKQCNSSFIPSVILIGVNMAFKTNAVEKCPLSALYKNSRKCLHYEVMLSYCAKKKGFETYRIVEKGLSPKVYHIANVESLTRGKGLSHQFWIQYDFSKDYWRLRKLGARVNFLHYLIAMGIIARGNLFIKIPATLYAIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A120</accession>
    <name>I0A120_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_0689"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="143" mass="16504" checksum="C5C3CF4460F36726" modified="2012-06-13" version="1">MGDIKMISIRDTVAYILSIAGCTSPFRISRMLVLANWKMLKEKGTIALRFKVDGFQAGFAVPEIEEIKRRIKDGSERCIKINEQKKCFEYVCEEKVELPREVSDVIQKVFDEIRSLDDISLNRIVVRDPHYPELLKRGGFHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A137</accession>
    <name>I0A137_FERFK</name>
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        <recommendedName>
            <fullName evidence="2">DUF2070 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="81"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2070" evidence="2">
        <location>
            <begin position="150"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="530" mass="58921" checksum="F7C85D252837784F" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A138</accession>
    <name>I0A138_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Short chain dehydrogenase</fullName>
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    </protein>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="protein sequence ID" value="AFH42695"/>
        <property type="gene ID" value="FFONT_0707"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="GDHRDH"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="258" mass="27276" checksum="C8FADAF23AFC8BE2" modified="2012-06-13" version="1">MEILSLKNKISIVTGGGSGIGRAIAEKLSSLGSTVIIFDVSEEGGLSTVREINSKGGSSYFFKVDVSNEESVKRGIENAVEKTGGIDVLVNNAGIEPPSKSLLELSVEEYDRVLNINLKGVWLMTKYATPYIAKRGGGSVINIASVAGIMPLAGAMPYSVSKAGVIMLTKVSAVELGKLKIRVNAIAPGWVDTPMIERAARNLKLTPEEFKKINSQRIILGRFASPEEIANAVAFLASDESSYITGSLVVVDGGISIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I0A154</accession>
    <name>I0A154_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cysteine--tRNA ligase</fullName>
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        <alternativeName>
            <fullName evidence="8">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="8">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysS</name>
        <name evidence="11" type="ordered locus">FFONT_0723</name>
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    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="8"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0723"/>
    <dbReference type="EnsemblBacteria" id="AFH42711">
        <property type="protein sequence ID" value="AFH42711"/>
        <property type="gene ID" value="FFONT_0723"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0723"/>
    <dbReference type="eggNOG" id="arCOG00486">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_2"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
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    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
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            <position position="30"/>
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        <ligand>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    <sequence length="475" mass="55711" checksum="A33577B1159F24EB" modified="2012-06-13" version="1">MPKIKIYNTLTRQIEEFVSSEEGIVKMYVCGPTVYDYSHIGHARTYISFDAIKKYFQLRGYKVIHVQNVTDIDDKIIKRANQEGKSWKEIADFYTEDYINAIEKLRIEPDILPRVTHHIEDIIDAVKRLIEKGYAYESNGSVYFDVSKYDAYGELSKKTGGENWRQEEEVIKEKKNPFDFALWKKMKEGEPYWESPWGYGRPGWHIECSVMSSKYLGVPIDIHGGGGDLIFPHHENERAQSEALFGIKPWVRYWLHTGMLTIRGEKMSKSLGNIVFLKDLLSKYKPEVIRLWVLSAHYRNQIEFNEELLRQAEANYKRITTAYIEIENQMKSAKPRFSLSKEEIETMNEIINLHREFHRAMSEDFNTTLAFKYWMEATSIYYKKVSNSENLSLFQSLKFLFDEIDRVFDILPQKVRSEGESELAESLIRLLIDVRKALREKGNYELADKIRSELGNIGIQLMDKGSETKYLVTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A157</accession>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="290" mass="33241" checksum="C2D13F4BDF779308" modified="2012-06-13" version="1">MNEEKLIFSDSHAHNNPIKGIGAKKIAEKFRENNGWFIAFLNNPAWDYSDSYIFDVDEYLKLVNLHMRDCKSATETGLKVKCFAGIHPAEIDKLAEYGLPTLKVRDFALKTIEKIFDMCKEGLLDGIGEIGRQHYKIRMDVAVITQEILESSFTFAKDYGCKIQLHLENIKGFTVENIASLAYKTGLKSDQFLIHHATSSIVEEAKNRRVWTTYPGIIEGLKSLFTTIRNPEYVLIESDYVDSKKEGGRITYPWNLPDIQLSLLEKGDVSKYFLEKINIDNVESFFDVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A171</accession>
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        <submittedName>
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    <reference evidence="3" key="1">
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0740"/>
    <dbReference type="EnsemblBacteria" id="AFH42728">
        <property type="protein sequence ID" value="AFH42728"/>
        <property type="gene ID" value="FFONT_0740"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0740"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="105" mass="11554" checksum="B94E4CBA81D125A5" modified="2012-06-13" version="1">MVFAMQFSSGTSIFSPEVQGILTLVLLAATLALFYYAMIQMSPKKTQEEVEVKTVITCTSTGQTTERAFQKGDYVGKILGECENSGQSVITSIFEVKKEINKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A180</accession>
    <name>I0A180_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0749"/>
    <dbReference type="EnsemblBacteria" id="AFH42737">
        <property type="protein sequence ID" value="AFH42737"/>
        <property type="gene ID" value="FFONT_0749"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0749"/>
    <dbReference type="eggNOG" id="arCOG00874">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008213_6_0_2"/>
    <dbReference type="OMA" id="IIVFTQY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="179"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="409"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="559" mass="63340" checksum="1AB6904FE5859ED3" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1A5</accession>
    <name>I0A1A5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphate transport regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0774"/>
    <dbReference type="EnsemblBacteria" id="AFH42762">
        <property type="protein sequence ID" value="AFH42762"/>
        <property type="gene ID" value="FFONT_0774"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0774"/>
    <dbReference type="eggNOG" id="arCOG02640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217531_0_0_2"/>
    <dbReference type="OMA" id="LGEEIRY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="227" mass="26527" checksum="D7ED6DAF392D40DA" modified="2012-06-13" version="1">MPQEIIRDDEILNMNLAEMNLAEQITNILLTINQEGKMAQELISGFIQGKMELVKKGYEPIKKIKDDAQRMKESTMEYVVRVSPTLMTKELYMFSLSHLDRISQIIDSIIYRLSILAHSGFTLDQSIAELFSQFSSTSFNMVELLYTESKYLSSNSKKVGEIHDEINRKEDLVDQLYRRLELEIIRKYSNDLFHLLLLKEVVDLIEELSDKIRDASHDFRYISLYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1B8</accession>
    <name>I0A1B8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator of molybdate metabolism, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0787"/>
    <dbReference type="EnsemblBacteria" id="AFH42775">
        <property type="protein sequence ID" value="AFH42775"/>
        <property type="gene ID" value="FFONT_0787"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0787"/>
    <dbReference type="eggNOG" id="arCOG00223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064037_1_0_2"/>
    <dbReference type="OMA" id="DYYFACD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12727">
        <property type="entry name" value="PBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="141"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="345" mass="39677" checksum="D99F7DEECDE44643" modified="2012-06-13" version="1">MEENEIKIKFEPILIFRGESILDSNGADILKAIEREESMISVSKKLGIPYSRVWELIVRIERVTGKKVVITQKGGKRGGKTKLTDFGKKLVSMYESALAYINKNIGPLSQYISISINSQLTMARSSDYIMDIVVNNAIKKGCKIDDLIIGSGLSLAMLALEKADIACMHLYDPITDDYNKSFIERFWLKDRVEKIISFKRELVFAYRRDLPHMELKDIIHKLLNGELKLINRNRGSGTRDLLDLLLKEEAKHLNKEVEKVVGYESEYQTDDEIIKMISSGKGDIGLTLRYLAEKHNLKYTHVKWETYECFSLKNIANKEEVSKLKDIYENTVKSYKDNIIGYIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1D2</accession>
    <name>I0A1D2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-superfamily hydrolase, subfamily IA, variant 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAD-like hydrolase superfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH42789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFH42789"/>
        <property type="gene ID" value="FFONT_0801"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0801"/>
    <dbReference type="eggNOG" id="arCOG02291">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_045011_8_3_2"/>
    <dbReference type="OMA" id="GNVMFWP"/>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
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        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
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        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="238" mass="26993" checksum="931756BDBEFA9C01" modified="2012-06-13" version="1">MVIPLIKALTFDVWDTILNEDKFYQLLSINIGKKLGKSGEEVFKNIMSIDRDAIKIRLEGGFKNIIYDTAEYFSNRLGLKNQEDLFNSVIEIIESEEICSLAFEDSISSIHEIKKMGMKIGLVGNVLFWPGMITRLILKRNGLLDYFDATIFQDEVGYQKPSKEIFQIASKRLNVSLNELGHIGDSLENDFVGAISSGMYGFLIKRDLNANYIELGKKAYAIRSLSFLSEIIKKINKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1E7</accession>
    <name>I0A1E7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42804">
        <property type="protein sequence ID" value="AFH42804"/>
        <property type="gene ID" value="FFONT_0816"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0816"/>
    <dbReference type="eggNOG" id="arCOG04811">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152986_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="85" mass="9287" checksum="201241BB3F298D10" modified="2012-06-13" version="1">MGILLGYILAKAFKYIIAFVLVIIAGAILNVWSISGSNGNLFGNLTEAKEYMQYVIQFAKFLSILLIGPVLAGFIIGLIIGWLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1F9</accession>
    <name>I0A1F9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">tRNA (cytidine(56)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="6 10">2.1.1.206</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">tRNA ribose 2'-O-methyltransferase aTrm56</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FFONT_0828</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>cytidine(56) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(56) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42968"/>
            <dbReference type="Rhea" id="RHEA-COMP:10308"/>
            <dbReference type="Rhea" id="RHEA-COMP:10309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.206"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the aTrm56 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.206" evidence="6 10"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0828"/>
    <dbReference type="EnsemblBacteria" id="AFH42816">
        <property type="protein sequence ID" value="AFH42816"/>
        <property type="gene ID" value="FFONT_0828"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0828"/>
    <dbReference type="eggNOG" id="arCOG01857">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123709_0_0_2"/>
    <dbReference type="OMA" id="VVHLTMY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00077">
        <property type="entry name" value="tRNA_methyltr_aTrm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002845">
        <property type="entry name" value="tRNA_mtfrase_aTrm56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42197">
        <property type="entry name" value="PTHR42197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01994">
        <property type="entry name" value="Trm56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016123">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 10" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="10">
        <location>
            <begin position="117"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="10">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH42816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="195" mass="21939" checksum="C07DAADC64A0E716" modified="2012-06-13" version="1">MEGIEPQAGILRLGHRPKRDKRITTHTALVARAFGASYYFLSEVCDMSVMDNVLSVEKRWGRGFKLVSCGLSYKDYISIWRNYMKGVIVHLTMYGLELEREIDGIKKAGKPVLIIIGSEKVPGEIYKIADFNISVGNQPHSEVAALAIFLDRLYNGQELYYKFEDAKVQIEPSASGKKVISIGGNKDEKEKYNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1G4</accession>
    <name>I0A1G4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative asparagine synthetase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0833</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O + L-aspartate + L-glutamine = AMP + diphosphate + H(+) + L-asparagine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0833"/>
    <dbReference type="EnsemblBacteria" id="AFH42821">
        <property type="protein sequence ID" value="AFH42821"/>
        <property type="gene ID" value="FFONT_0833"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0833"/>
    <dbReference type="eggNOG" id="arCOG00071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_3_3_2"/>
    <dbReference type="OMA" id="IEHSHQP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="2 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="1 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="2"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="641" mass="74221" checksum="5132013F3F5DAA10" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1H2</accession>
    <name>I0A1H2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantoate kinase</fullName>
            <shortName evidence="1">PoK</shortName>
            <ecNumber evidence="1">2.7.1.169</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP = (R)-4-phosphopantoate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28246"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. PoK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.169" evidence="1"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0841"/>
    <dbReference type="EnsemblBacteria" id="AFH42829">
        <property type="protein sequence ID" value="AFH42829"/>
        <property type="gene ID" value="FFONT_0841"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0841"/>
    <dbReference type="eggNOG" id="arCOG04263">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081191_1_0_2"/>
    <dbReference type="OMA" id="MLGETVF"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02223">
        <property type="entry name" value="Pantoate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012043">
        <property type="entry name" value="PoK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42282">
        <property type="entry name" value="PTHR42282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016896">
        <property type="entry name" value="GHMP_arc_MJ0969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="291" mass="32698" checksum="6FC9B8A9FA437398" modified="2012-06-13" version="1">MLLVKLLRRNGEDRCIKIAHHISTFWAPVYKDNELYTGSIGAGILISPYAIACLNEESSFEEPSDLIKEIDKMMGREKSLHFKYIDELPPAYGYARSASLAIGYTFLSFIYENKKFTLFDIGRIAHVAEVRSKTGLGDVSAILGGRKIPIRLKAGAPGISLVDSLMIREKISIITIPLKKISTKDMLKNKEREFYNAGMEAMRLFLDEPDFEKLVTLAYDFSKKTGMLSEEVESVIKEVTKSVGIIGYFIKKGIVVLFAEEGTEDDVIEMAKKKLKTQPFKHKLLDTGIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1M2</accession>
    <name>I0A1M2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0891"/>
    <dbReference type="EnsemblBacteria" id="AFH42879">
        <property type="protein sequence ID" value="AFH42879"/>
        <property type="gene ID" value="FFONT_0891"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0891"/>
    <dbReference type="eggNOG" id="arCOG02008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100105_0_0_2"/>
    <dbReference type="OMA" id="IGIYHEG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009339">
        <property type="entry name" value="DUF998"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06197">
        <property type="entry name" value="DUF998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="190" mass="22059" checksum="4AF9CD9507BA37FB" modified="2012-06-13" version="1">MRKNPSKWIRYFKYQGIIAFLIAFIGILIAVKLNPWFDVSKNALSDLGRIGLKYSSIFNITLIISSLFAISYIPYMLKLLSNKFGAFSVGVYTVGAFHLFLIGMFPEGTKFHWFVSLEFFILMSISLLLFSITMLTLKRKTSFFLFLILFLLSLLGSLFVRWPSTALLEIYNITIYFFGFLILYFSEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Q3</accession>
    <name>I0A1Q3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42910">
        <property type="protein sequence ID" value="AFH42910"/>
        <property type="gene ID" value="FFONT_0922"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0922"/>
    <dbReference type="eggNOG" id="arCOG05969">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989030_0_0_2"/>
    <dbReference type="OMA" id="IFAYLTM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="281" mass="32579" checksum="E3E76E39441EA1AB" modified="2012-06-13" version="1">MILDSSIEEKLRTLKRLDGVIDFSKSSVQIEIVFLFLIYGRDLTPTEISESANERRKAVLDALRKLQLKGIVKKVGEKDGEPLYGLSEEGKKYSEELLRALGLEGFKLASHVSEEESIRERLIVQKKIIEANYIYNAICYLATSKDQTLSLKTISRLLNLSEERAKEYLDIYSRPPERLFRKIIKPDTRETYYKLEKEGLSIFYRTQNYLSFKNSPIYKLKQKLYAKIPHPNNLKRLFSISSFLSFLLSFLLSILNLCSLFFSVLMFVLGSVVFVIKEVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Q5</accession>
    <name>I0A1Q5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Archaeal flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the archaeal flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0924"/>
    <dbReference type="EnsemblBacteria" id="AFH42912">
        <property type="protein sequence ID" value="AFH42912"/>
        <property type="gene ID" value="FFONT_0924"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0924"/>
    <dbReference type="eggNOG" id="arCOG01829">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084671_0_0_2"/>
    <dbReference type="OMA" id="AYPLERN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097589">
        <property type="term" value="C:archaeal-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013373">
        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002774">
        <property type="entry name" value="Flagellin_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35903">
        <property type="entry name" value="PTHR35903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01917">
        <property type="entry name" value="Arch_flagellin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0974">Archaeal flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="224" mass="23288" checksum="91545AFCC08151E9" modified="2012-06-13" version="1">MGKKRGIVGIEAAIVLIAFVIVAAALAFVALNMGLFTTQKAKETISQGLGEASTALEVDGYVVGISNGTTVNTVSIPIRTSAGVSSVDLAPSRTSIDAIVGNQSFENIYKAIFYVYPNGTLAYANNGTLTNLTTDFSTHNLTADIESVLGSPSTPTAYVVIIQNVNYNSVLETGEKAVVLIDLENNGLGPYGQLSVEIRPPEGAPLTVERNMPANIPAGAVNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1R5</accession>
    <name>I0A1R5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0934</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0934"/>
    <dbReference type="EnsemblBacteria" id="AFH42922">
        <property type="protein sequence ID" value="AFH42922"/>
        <property type="gene ID" value="FFONT_0934"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0934"/>
    <dbReference type="eggNOG" id="arCOG01601">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058423_0_0_2"/>
    <dbReference type="OMA" id="CESAMVL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="4">
        <location>
            <begin position="52"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="319" mass="35361" checksum="F465CC6EDB2C5240" modified="2012-06-13" version="1">MIMQSEFKSLREIPPIDYYTAGRRTCAGCGPAIGYRLISKAAGPNTIFIGPTGCMYVANAHQFLTSPYSVPWHHTQLGGGGAAAIGIASALRTLMLKGKRKPEDINVIVMGGDGAMADIGLSGLSMGLSYDYQRLLYIVYDNEGYMNTGVQASSTTPWGATTTFTPSGKVKPLGNTRYKKNVALIAASHPNVKYVATATLWPPLDLMNKVVRALNSGGPSVIHALFPCPKGWFTSPADTVMLSKLAVETGMWVLWELIEGQFKLNYRPNPRKHVREYLSLQGRFRHLKDEDIDKMDKMIEEEWFYWNESAKQEKLILPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1S7</accession>
    <name>I0A1S7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor IIB</fullName>
            <shortName evidence="5">TFIIB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tfb</name>
        <name evidence="8" type="ordered locus">FFONT_0946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0946"/>
    <dbReference type="EnsemblBacteria" id="AFH42934">
        <property type="protein sequence ID" value="AFH42934"/>
        <property type="gene ID" value="FFONT_0946"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0946"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="RTQKDFA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00383">
        <property type="entry name" value="TF2B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023484">
        <property type="entry name" value="TFIIB_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023486">
        <property type="entry name" value="TFIIB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="TF_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
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    <keyword evidence="2 5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="1" evidence="5">
        <location>
            <begin position="131"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="7">
        <location>
            <begin position="131"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="5">
        <location>
            <begin position="225"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="7">
        <location>
            <begin position="225"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="316" mass="35927" checksum="B594A60BD6E169B1" modified="2012-06-13" version="1">MKLLKKKKKEEARKSENESGCPPNAIVFDPERGEYICTETGEVLEQKLVNQGPEWRAFTPEEKEKRSRIGGPLSPTVHDRGLTTLIDWRDRDASGKKLEPKKRLEFLRYRKWQIRSRIQSSIDRNLAQAMNELDRLSNQLHLNRAVREEAAVIYRKAVEKGLVRGRSIESVIAASVYVACRLKKLPRTLDEISLHTRANRKEIARCYRLLVKELQLKVPIADPIDYIPRMGSLLDLSGKAMNIAARIVKIAKQKALTAGKDPAGLAAAAIYVATLLENEKRTQKEIANIAGVTEVTVRNRYKELVNELKLDIPEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1V7</accession>
    <name>I0A1V7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein UspA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0976"/>
    <dbReference type="EnsemblBacteria" id="AFH42964">
        <property type="protein sequence ID" value="AFH42964"/>
        <property type="gene ID" value="FFONT_0976"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0976"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="SEICLIT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
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    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="5"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="151" mass="16661" checksum="E1DC104EF66BB83C" modified="2012-06-13" version="1">MKNIYEKIVIGFDGSASSRLALQKACELGERFGSELNVVLVIEPLDVYYGEPIPDVEISKQKEAANMIIEKAKKIAANYKIKNVNYMVKYGVPANEIMKTATDIKADLIVVGRKSKKGLLEKVLLGSVSQSIVNLSKDIDVLITPYIEPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1X0</accession>
    <name>I0A1X0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease Z</fullName>
            <shortName evidence="9">RNase Z</shortName>
            <ecNumber evidence="9">3.1.26.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA 3 endonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">tRNase Z</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnz</name>
        <name evidence="11" type="ordered locus">FFONT_0989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="9"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0989"/>
    <dbReference type="EnsemblBacteria" id="AFH42977">
        <property type="protein sequence ID" value="AFH42977"/>
        <property type="gene ID" value="FFONT_0989"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0989"/>
    <dbReference type="eggNOG" id="arCOG00501">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_2_1_2"/>
    <dbReference type="OMA" id="GTQRQMM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07717">
        <property type="entry name" value="RNaseZ_ZiPD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01818">
        <property type="entry name" value="RNase_Z_BN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013471">
        <property type="entry name" value="RNase_Z/BN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0819">tRNA processing</keyword>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="261" mass="28994" checksum="557A2FFDA26AAE6E" modified="2012-06-13" version="1">MSEAWILFLGTAAGTPSKKRGLPSILLQYRGKYILLDIGEGSQRSLIKNGIGVNRIDHILISHLHGDHIFGLPGIIQTMSMEGRERKLSIISPEGIEKILNAASQITSYQLEFPIEIIKPEGEISLEQYISVYPFKTCHTNIESFGYIIKAFGTGKEKKERFSLAYTGDTAPCEELIEKIKGADVLIHDSTFDSSMVEKAIAFGHSTSSIAAKVAKMAGVKSLILFHISNRYNDKSEMILDNALKIFKNTFLAEDGMKFYI</sequence>
</entry>
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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    <sequence length="106" mass="12918" checksum="F01095B207EFCFE2" modified="2012-06-13" version="1">MRAKFTANIDILDYYIGGLVDRIVMKGYYDIDLDREYDHLMWYIYEKLVVILFKGKEPTREEFEEKMKKIRRRDADKLKVLISYLISKYMKMRNIQSTGKRSQDDF</sequence>
</entry>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <location>
            <begin position="17"/>
            <end position="82"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
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    <sequence length="177" mass="20789" checksum="4222FC2A831CD2CE" modified="2012-06-13" version="1">MKAKKTLKDFLKGEKEEETHNDEIEEIIKRMDILEMKVSELEKKIEELREKINEIENVFGRSKEASGKIEQINMLLDKLRNKGYLKESEDLARVKDKDFVADRIKKLGAIEVIGTKDRYLIYPRKWKEFLEKLSSISDSDPSSAAEKIGDLKELFFELLKEGLIYFDAKNRKWKSIS</sequence>
</entry>
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                <person name="Mardanov A.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
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                <person name="Perevalova A.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </evidence>
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        <source>
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    <sequence length="408" mass="44679" checksum="1D609F63DAE6EBC1" modified="2012-06-13" version="1">MAQSGQKESKTTLYVLILVGIIAIGSIIISYQNTRGISQINNDIEKMTQITLNLSNQIDSIQQSLNEYKLMSQQISSLNQSLSQQIQSLNNMIAQMNYPIQVYDALNRTVVITQQPTRIVSLAPSTTEMLFDIGAGNLVVGVDDNSNYPPIVNELVINGTIQRVGGFDSISLEKVISLKPDLVVGSTGVQFKYIYQLSQYGITALSLNDESISDILTDILLLGKITGHYQQALNLTNNLKNEIISIYSKVSGSQNKPTVLFIVWVNPYYAAGGSSFWNDLISLSGGLNSLENVSQAWPAISWEDVVKLNPQVIIATEYAGGFSNATQLINWLESQPGGANISAVETGRVYMLHGNLSDIASRPSPRIVEMQEVLAAILHPEDFGNIQLPNDLNDTILAQISQYVQSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_1079"/>
    </dbReference>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="583" mass="64744" checksum="B6C6895B421C7D88" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A279</accession>
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    <protein>
        <submittedName>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
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                <person name="Kublanov I.V."/>
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                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <source>
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    <evidence type="ECO:0000259" key="3">
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    </evidence>
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            <dbReference type="EMBL" id="AFH43086.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <sequence length="98" mass="11523" checksum="F6BE48D876499982" modified="2012-06-13" version="1">MEMNRKMKYSIKQMNEKELEIVLYDEDHTFGNLMAKTLMKIDGVVMSYYRIDHPLKNEMVLYLKTDGSIKPVEALKKGIGLLKDEIRELETKIKEVQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A283</accession>
    <name>I0A283_FERFK</name>
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        <recommendedName>
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    </protein>
    <gene>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
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            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DPH1/DPH2 family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1102"/>
    <dbReference type="EnsemblBacteria" id="AFH43090">
        <property type="protein sequence ID" value="AFH43090"/>
        <property type="gene ID" value="FFONT_1102"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1102"/>
    <dbReference type="eggNOG" id="arCOG04112">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037146_0_0_2"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022428">
        <property type="entry name" value="Dph2_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="PTHR10762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03682">
        <property type="entry name" value="arCOG04112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH43090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="342" mass="38582" checksum="80CA8F4F9808418A" modified="2012-06-13" version="1">METLDYDFNLPDLVSKISNLNPKSIILQFPDGFKLFSIAIADYLKNYLKDVKIYISAESTWGGCDIAIEEAKMLGAELIVHFGHTPYSLAEYKSILEKVPVIYVPGKFKKELSKSSLISLLFELNKIGASKPALVSTIQHVDALKQIRDFLNERGISATIPKSPLMEEGQIVGCDYSPLINEKNYDSVVVVSGGYFHAFGAGLMTMKPTIKIDPYTDKVENVTENVKKILKKRYATMERSKSAEVWGIIIGTRTGQYRPITIRALESLIKNKGKKYYLFFSKSLTINELRNIDQPKIDAYVVTSCPRIPIDDISEKEFEKPVLTPGEAFMVLKGELERYRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A289</accession>
    <name>I0A289_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L21e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl21e</name>
        <name evidence="6" type="ordered locus">FFONT_1108</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1108"/>
    <dbReference type="EnsemblBacteria" id="AFH43096">
        <property type="protein sequence ID" value="AFH43096"/>
        <property type="gene ID" value="FFONT_1108"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1108"/>
    <dbReference type="eggNOG" id="arCOG04129">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103610_1_1_2"/>
    <dbReference type="OMA" id="KGMPHRR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00369">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_L21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_L21e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022856">
        <property type="entry name" value="Ribosomal_L21e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_L21e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="PTHR20981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="101" mass="11680" checksum="29624F17D0BFD3D1" modified="2012-06-13" version="1">MVKAPKGYRHRTRKLFKKDIRERGGVPSLSLLMIKYNVGDKVMIYINPSIHKGMPHRRFHGRTGVIVGRRGRAYIVELYEGSVKRTLFVRPEHIRPLTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2A3</accession>
    <name>I0A2A3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative replication protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1122"/>
    <dbReference type="EnsemblBacteria" id="AFH43110">
        <property type="protein sequence ID" value="AFH43110"/>
        <property type="gene ID" value="FFONT_1122"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1122"/>
    <dbReference type="eggNOG" id="arCOG07629">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1122585_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="247" mass="29433" checksum="8AF3E5ADFC68D191" modified="2012-06-13" version="1">MDNILISEAVYFLKKIWNYQSELANCFSLVWIKKDNQRDLGYIHFCKQIYGKDLFSKIYEWLRQNLSNLAMEGYDIYYQVLPLWRKPEKGRGTKNEVKISKWLWCDLDFKEEVLDVELDDNLKEKLKFKDYYCEEKDNYGLFCTYRKNKYSWYVVKRPALAEILEKAAKSFRLPDIVVDSGNGYHLYFELNKEESALKILSLEENVVELLGGDEKSKDLARILRLPGTVNQKNKRISKVIYRKNNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2B3</accession>
    <name>I0A2B3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">nnrE</name>
        <name evidence="14" type="synonym">nnrD</name>
        <name evidence="18" type="ordered locus">FFONT_1132</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1132"/>
    <dbReference type="EnsemblBacteria" id="AFH43120">
        <property type="protein sequence ID" value="AFH43120"/>
        <property type="gene ID" value="FFONT_1132"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1132"/>
    <dbReference type="eggNOG" id="arCOG00018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_2"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01049">
        <property type="entry name" value="YJEF_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="18" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="11"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="136"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AFH43120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="515" mass="56047" checksum="885BAAD3C29B6ED8" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2C1</accession>
    <name>I0A2C1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Competence damage-inducible protein A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1140"/>
    <dbReference type="EnsemblBacteria" id="AFH43128">
        <property type="protein sequence ID" value="AFH43128"/>
        <property type="gene ID" value="FFONT_1140"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1140"/>
    <dbReference type="eggNOG" id="arCOG00215">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_0_5_2"/>
    <dbReference type="OMA" id="IGNVIVM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="1">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="280" mass="31499" checksum="9C00E62000CA441F" modified="2012-06-13" version="1">MKEKVMYNMERFFSPPQNENVWIINTGTELLNGITVNTNASWLARKLSFLGFKVKRIIVVPDEFEEFSNELKRALENKAGIVITTGGLGPTYDDNTLLFISKSLKIPYEVNEDALNMVKKVYEAMSEPLTKEREKMAKMPKGSIPLKNPVGTAPGMMLYYSGSYIISLPGVPSEMKAIFEEDLESVLKMWSKKKVSENIIKVRGIMESAIAPLIEKASKKYLNAYIKTHPKGKESNEPYIEIQILATGNTEEEANKLASEITSDIINEIETKFSGGKIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2E7</accession>
    <name>I0A2E7_FERFK</name>
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        <submittedName>
            <fullName evidence="5">AAA family ATPase, CDC48 subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1166</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. CDC48 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1166"/>
    <dbReference type="EnsemblBacteria" id="AFH43154">
        <property type="protein sequence ID" value="AFH43154"/>
        <property type="gene ID" value="FFONT_1166"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1166"/>
    <dbReference type="eggNOG" id="arCOG01308">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_12_2_2"/>
    <dbReference type="OMA" id="HACHDIK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="SSF54585"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
        <location>
            <begin position="111"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="222"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="496"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="729" mass="81562" checksum="D0A1FF5594484F40" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2G7</accession>
    <name>I0A2G7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1186"/>
    <dbReference type="EnsemblBacteria" id="AFH43174">
        <property type="protein sequence ID" value="AFH43174"/>
        <property type="gene ID" value="FFONT_1186"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1186"/>
    <dbReference type="eggNOG" id="arCOG05993">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1329415_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="206" mass="23803" checksum="51B208CFA89A84E1" modified="2012-06-13" version="1">MLAQSVCNIYKSEGVEVFAVEISPINRNIIEKYIQANCNQASINIIPPHSIEELQMKKNNTNVPIIIFSIGENLDDYINDFLRLKRNVRLLFTHVSKGINRIFGMNILRLEKDYSGFYIKYGGLKKYLKYKNGKLLEADEGESYFLEKAYKVLLDSMLEFGEITLEDATNVLMGRLKISKNEAKKLLYELIKRKKLEFKGGILHIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2J5</accession>
    <name>I0A2J5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1214"/>
    <dbReference type="EnsemblBacteria" id="AFH43202">
        <property type="protein sequence ID" value="AFH43202"/>
        <property type="gene ID" value="FFONT_1214"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1214"/>
    <dbReference type="eggNOG" id="arCOG01159">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080079_0_0_2"/>
    <dbReference type="OMA" id="DESQACH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="294" mass="34594" checksum="3180D8BEAE53440C" modified="2012-06-13" version="1">MGDSVGETLEKISEDIYNLKQEIATLKEERIGLIEDLKKIKEEKRNLIESSKSVFEEINKKKDEKNAILEEIKKLKSEKDEIAKKIEELKLVIKRYEELINKTPNGQSLSSLKKRIEQLTWKQQTTPMSIDEEKKLMQEIDRLTQLYNRLKDARDAESKLMEVKAEYTSLKIKFKDIKNSMQEKIKKFESIKKEISSLREKINGISQKIDQANKEITEISNRLNQLKASIDEKYEHLKKLQEESAKIKEEESKKKESEILEKKKKIAEEKLKKKERLTFEDLLALYGEEKDSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2L2</accession>
    <name>I0A2L2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1231"/>
    <dbReference type="EnsemblBacteria" id="AFH43219">
        <property type="protein sequence ID" value="AFH43219"/>
        <property type="gene ID" value="FFONT_1231"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1231"/>
    <dbReference type="eggNOG" id="arCOG02466">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165884_2_1_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="93" mass="10513" checksum="FE19B6177B36DA2F" modified="2012-06-13" version="1">MVKVLLKKLGVIEKVATNNLLLVKITDSKNIPNIGNRVLLPDFRGFGKVMDVIGNVNNPYAVIKPFKKEEDLSKYIGQVLLVDERTFTSRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2P2</accession>
    <name>I0A2P2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1261"/>
    <dbReference type="EnsemblBacteria" id="AFH43249">
        <property type="protein sequence ID" value="AFH43249"/>
        <property type="gene ID" value="FFONT_1261"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1261"/>
    <dbReference type="HOGENOM" id="CLU_2730167_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="71" mass="7984" checksum="CBAB2517FF8DBD5A" modified="2012-06-13" version="1">MNIESFKLNKSSFSVENLTFQGGMKIIVFLALSFITDLLAFWGGEAFSCKESIIQLKGTLSREESKLFTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2R9</accession>
    <name>I0A2R9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Component HyfE of membrane-bound [Ni,Fe]-hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_1288</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1288"/>
    <dbReference type="EnsemblBacteria" id="AFH43276">
        <property type="protein sequence ID" value="AFH43276"/>
        <property type="gene ID" value="FFONT_1288"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1288"/>
    <dbReference type="eggNOG" id="arCOG03626">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088957_2_0_2"/>
    <dbReference type="OMA" id="IFFDLLM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038730">
        <property type="entry name" value="HyfE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38601">
        <property type="entry name" value="PTHR38601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH43276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="220" mass="24704" checksum="FB918C82D74E70E5" modified="2012-06-13" version="1">MEVVKMTSNIAIIINGLSALMIFTAIWISETIDLRRAANIYRLQSFLLTLIFAMMSIRDSYFLIWALVAFVTKTLIVPWLVIKSLEKSGERKDIKTSIPSWLTMVIYAILLVFSFWTGGQFKGMIGEDYIPLSVSISLFLIGLKQMVTKKSIFKQILGLCHFENGSHLTLALLAPGIPETIEIGCTTDAVFLIAVCCILAVHIKKVNNTVDVTQLKNLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2T8</accession>
    <name>I0A2T8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="3 10">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FFONT_1307</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="10">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="3 10"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1307"/>
    <dbReference type="EnsemblBacteria" id="AFH43295">
        <property type="protein sequence ID" value="AFH43295"/>
        <property type="gene ID" value="FFONT_1307"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1307"/>
    <dbReference type="eggNOG" id="arCOG00790">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106570_0_0_2"/>
    <dbReference type="OMA" id="DWECRYC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="11">
        <location>
            <begin position="40"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH43295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="210" mass="24845" checksum="AA2B444DAD720979" modified="2012-06-13" version="1">MTENVPFDQLNFSNIVIKKVYEEKLKEFNDRLSEIKNPNIIYVSDLVYCPLKRLFRMQYPEISFIFEPQAIQGELIHKGLQLYLKDLGYEIEKEISEKIYINSEEFVLKGRMDAYKEGEEVIEIKTAKSSLGIPHDHHILQLKIYLSMTNISKGTLIYVSPDRIAEFPIKKDNLDLSKLVFDYLSKKYAPRWDWECKNCIFSKLCPYRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2U2</accession>
    <name>I0A2U2_FERFK</name>
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        <submittedName>
            <fullName evidence="3">Lipoate-protein ligase A (LplA-1)</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">FFONT_1311</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_1311"/>
    </dbReference>
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        <property type="reaction ID" value="UER00595"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
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        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="PTHR12561"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="34"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="258" mass="29663" checksum="F2DD4800B5D70FDC" modified="2012-06-13" version="1">MKLGELRVLLEERPEDPYMNLSIEEALFISRCRDDGDDILRIWRNKNAVVIGVFQVPEEEVDLEYAKNNGIAITRRFTGGGAVYHDLGNINFAFSTKVPEGEKGGVDYLFNYLINGAIYALEKLGFSPKKENYNDIIIDGKKIIGIAGSIRRNCAFIHGAMLYNTNLSVLSSVLKVPLKKLAEKKVSSVKYRVTTISQIRNDIRERDVVNALIYGFMRVKDLKGFYLDFLSEKEFDLSLELYKNKYSTYEWNYERKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2U9</accession>
    <name>I0A2U9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH43306">
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        <property type="gene ID" value="FFONT_1318"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3282698_0_0_2"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="40" mass="4904" checksum="FC16A63E74528B09" modified="2012-06-13" version="1">MQRMQIMRVRTEHKAIELFQRSRKVSELLIFSVDKIPIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Y0</accession>
    <name>I0A2Y0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-bound oxidoreductase, subunit MbxJ</fullName>
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        <name evidence="3" type="ordered locus">FFONT_1349</name>
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    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
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    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43337">
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    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1349"/>
    <dbReference type="eggNOG" id="arCOG01554">
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        <property type="component" value="Chromosome"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="52"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="175" mass="19836" checksum="B343B940DCB66142" modified="2012-06-13" version="1">MEIAIEIANSISNKIMRFTIKLVKRILKPFSGMIDWANSYSLWPVHFTTSCCGCEFAATYDPRFDSERYGSLPFTHVRDTNTIIIEGTISKKMAKALKVVYDQMPSPKYVIAMGACAIDGGIFYNSYNVVKPRDFLPVEVYIPGCPPRPEAVENAILTMQRRIRELRIASKKVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Y4</accession>
    <name>I0A2Y4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-bound oxidoreductase, subunit MbxN</fullName>
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        <name evidence="3" type="ordered locus">FFONT_1353</name>
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    <organism evidence="3 4">
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1353"/>
    <dbReference type="EnsemblBacteria" id="AFH43341">
        <property type="protein sequence ID" value="AFH43341"/>
        <property type="gene ID" value="FFONT_1353"/>
    </dbReference>
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    <sequence length="665" mass="73518" checksum="11EA8C842AA5130D" modified="2012-06-13" version="1"> </sequence>
</entry>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43366">
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        <property type="gene ID" value="FFONT_1378"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1378"/>
    <dbReference type="eggNOG" id="arCOG04261">
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    <dbReference type="Proteomes" id="UP000007391">
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="215" mass="25143" checksum="8EFB95E9EC0BBAD4" modified="2012-06-13" version="1">MWFLIEQEEKTVVGSVYDRVKMLLLNYGSKAEEVMLAALKRAEELDANGNGFRFGDFDFKGLKEKLTEMEVKYNPNILLRIMERDYLIIETTYKSGNQHWWNFTDRKAVESILLSSGKSSREKSGEDLKYISIKAMYASLEPGKLLEALESISRKRRLDDIDKRLFKKIVFEEMKNIVSLIESMKEMESRFEGELKVLYRIVDLIDSLSNKLIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ49</accession>
    <name>H9ZZ49_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative transporter component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0010</name>
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    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42006">
        <property type="protein sequence ID" value="AFH42006"/>
        <property type="gene ID" value="FFONT_0010"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG05331">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591375_0_0_2"/>
    <dbReference type="OMA" id="RMANGCA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="94"/>
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        <location>
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        <location>
            <begin position="191"/>
            <end position="211"/>
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            <end position="291"/>
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            <end position="406"/>
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        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
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        <location>
            <begin position="66"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="453" mass="49975" checksum="2BB4BC81B54027DD" modified="2012-06-13" version="1">MEKDEKIFLGATVTLLIISLLMLFGGIYMQIVLHETKAPLLLGIVAGMLLAIPLELWNFSDPDTLYRVMAFQDRFLMVCFGFAIGFGAILLYALNLIVPSPNFGIKSFFVPGVIIGGIIFGIGVGIAGYFPGTVWIALGQGRRDAIWALLGGLLGAFTWSLIFGYAKPFFWDTLNYGPITWADILGKTSKIGMFEVSLIFGTVLILLFLILPRYPGEKIKDSCGAHILGLSKSVIQFNDLINEEKEKYPHARPFITRITNESSIKNARYILILGAEFTITAVAVIILHQIFGESTTYSWIGAQLSYLLNPMWAASNLYFQLFGGMHLVNGVPVNNPFSEIGWEPLSDLGTFLGGLISATLISKRFMAFKPLVPKVWERRFGPSETKRAIGSFIGTFLVLFGARMANGCASGHILSGNIQMAVSSFVFMVTVLLSAWIVLYGMLRLKINKIGYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ55</accession>
    <name>H9ZZ55_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0016</name>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="eggNOG" id="arCOG02217">
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    <dbReference type="OMA" id="RVNWAEE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039709">
        <property type="entry name" value="VapB3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42244">
        <property type="entry name" value="PTHR42244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="76" mass="9078" checksum="2D4822967325DE40" modified="2012-06-13" version="1">MSVFSLKLRRDIKEKMNRYKDKVNWAEEIRKFIEEKLRTLEAEDNIKKIVEELSQIPIESPRGSSTSSVREDRESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ76</accession>
    <name>H9ZZ76_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TsaA-like domain-containing protein</fullName>
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    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0037</name>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
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        <property type="protein sequence ID" value="AFH42033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1163730.FFONT_0037"/>
    <dbReference type="EnsemblBacteria" id="AFH42033">
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        <property type="gene ID" value="FFONT_0037"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG00761">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OMA" id="VCRLEIF"/>
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    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="4">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="178" mass="20686" checksum="DECDA498EDCE61B6" modified="2012-06-13" version="1">MEEICLKPIGFVRHEKDEELRRRWEGVEGEIEILPEYEEGLKGIEGFSHIILIAYLHLVEGEKRRVLKVKPRRLRNFGISIDDLPEVGVFSSDSPHRPNPIAISIVKLKGVQGRVLEVEGLDLYSGTPILDIKPYGYERRIEEIRVPWWSDEVKRRVEEKMGREKKRGKADESPDLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ90</accession>
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            <fullName evidence="1">Anaerobic ribonucleoside triphosphate reductase</fullName>
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    </protein>
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    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0052"/>
    <dbReference type="EnsemblBacteria" id="AFH42047">
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    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002707_0_2_2"/>
    <dbReference type="OMA" id="YSYDRVP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008998">
        <property type="term" value="F:ribonucleoside-triphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012833">
        <property type="entry name" value="NrdD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13597">
        <property type="entry name" value="NRDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02487">
        <property type="entry name" value="NrdD"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="635" mass="73458" checksum="21DF66825FF59F93" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ92</accession>
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        <submittedName>
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    <reference evidence="2" key="1">
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42049">
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        <property type="gene ID" value="FFONT_0055"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="CIGATHS"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002808">
        <property type="entry name" value="AdoCbi_amidolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01955">
        <property type="entry name" value="CbiZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="215" mass="23300" checksum="44F5CD1C98E6E2E8" modified="2012-06-13" version="1">MAKVIDESSDFLLIDLEGELMSLSTSGCPKVYERARYLAFKRVPKGFEHVDLDEYCREVSRSLGVDIEETALFFTAVDLRNYSKGSYSHRGVKAEAFVTYGVDSPSCFEERRREIGTINVAVIVEKPMSRVGLLDLFRTVSEIKGMSISLGGPMCPSHSSVGTASDATMVASPQGDESFGGIATDVGISASLALLEAISQQIASIPLTFNFCPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ93</accession>
    <name>H9ZZ93_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0056</name>
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    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42050">
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        <property type="gene ID" value="FFONT_0056"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG01440">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929440_0_0_2"/>
    <dbReference type="OMA" id="MIDWDLL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="279" mass="31183" checksum="A8E940B62D15C60C" modified="2012-06-13" version="1">MNIKGYRVIVEVESSQPVVEFTGRLVKSFVFALNPHLELMKGFEGILSPLHISPLFKVKLDHDFGEPAYTFAVVSKKEEREIEPLNLNGEFVFHVGGDESTVNNVVDKIGKINGSIFLRIHDALVKYKVEKIVDVTEEVFGKVYQITDKVKVYLKSPAQIFNPYASTKLPKFTPSAIEVLIAPYAILNRNYTITESLVVSSFPTIGKLVETWYSIKTLRPIAIFFKGKKQVNLAGSITYLIQNENAKELEMVQKTLAVAELAGIGRSRQNGFGTTVVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ94</accession>
    <name>H9ZZ94_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRISPR_Cas6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0057</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0057"/>
    <dbReference type="EnsemblBacteria" id="AFH42051">
        <property type="protein sequence ID" value="AFH42051"/>
        <property type="gene ID" value="FFONT_0057"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0057"/>
    <dbReference type="eggNOG" id="arCOG01439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929391_0_0_2"/>
    <dbReference type="OMA" id="KVRAFKF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="1">
        <location>
            <begin position="153"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="299" mass="33277" checksum="73E6D63DF72E5141" modified="2012-06-13" version="1">MLKKVNAIVEEFLRTRSLIRISYRVKSRDFIMLPPLSSNLLKAAVASSEDLHNIWEMYAESKRPRKVLYKALRLPGSGGRLVALEGKKGLLHMDPDKFYEAEIVLISDSNALMSYLPKPYVSVKTPYGEVELEVTTIDIIREVPASTAGSVRVRFLTPTILSKKIATPPWLSKRASALKDSYSLLPTPGLLAGSVLKNLLEHLGEIGKKDQRVPYMALRFFDLFVEEVDHELKPVTVLLGKDDKGNMRRGRGIIGWINYRAMNEGVAGAFVRLLKIAEIVGVGKSRGIGLGEISLFLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZA8</accession>
    <name>H9ZZA8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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                <person name="Gumerov V.M."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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    </evidence>
    <sequence length="190" mass="21812" checksum="40D2B4C3F88770FB" modified="2012-06-13" version="1">MDAHSALSEIRRKKIFGVELKGGKAMKFAFKPCLRNAQLEDDAIVLPDLYSANGELDFFPAYPYLFFPNFRDLDISYIGSYAHDALKFFPKFRTIEEKQGDQWELLVEREDGVKFLSKSTALSQILANIEVNPGIRWGELLGIFLEKADEMDLKDEEERKEVLSWIEKGYIAPRLGMLWHEADLIDADSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZE2</accession>
    <name>H9ZZE2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0106"/>
    <dbReference type="EnsemblBacteria" id="AFH42099">
        <property type="protein sequence ID" value="AFH42099"/>
        <property type="gene ID" value="FFONT_0106"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0106"/>
    <dbReference type="eggNOG" id="arCOG03681">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153630_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="144" mass="15769" checksum="184384BBF58306AB" modified="2012-06-13" version="1">MTEELPFISLLKLELIKRNPHEEVMIQKSVLPDPEAVGFKKALGEPKGQRADYSYPLENGGRIHLLDYGDHYRAHRDNVDPDRDPIGHLIYDSPRIALALGAIVGGLLGKSSSKGDKTEGFLCGALIGLLLTSIFLVGSPPLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZE9</accession>
    <name>H9ZZE9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Haloacid dehalogenase-like (HAD) hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0114"/>
    <dbReference type="EnsemblBacteria" id="AFH42106">
        <property type="protein sequence ID" value="AFH42106"/>
        <property type="gene ID" value="FFONT_0114"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0114"/>
    <dbReference type="eggNOG" id="arCOG02293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_1_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="198" mass="22558" checksum="751FB94A9B622918" modified="2012-06-13" version="1">MIRAVMFDFDGTVIDTMNEYAGLASEIIEEIAGIDREKAKSLYLSTAGMSFKEQLKIMGIEGGKAEEIYRRFIEGKMVILKSKRISPHVEILIGNLKERGIISSLSTNNECSVVYLIEGIRAFDEVLCFNGSDSYKGEPHLKFLMEKYGLRKEEIVFIGDSDYDIRTYSVLGIKSIKTRGIFSEEERERIIREILEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZG6</accession>
    <name>H9ZZG6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0131</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0131"/>
    <dbReference type="EnsemblBacteria" id="AFH42123">
        <property type="protein sequence ID" value="AFH42123"/>
        <property type="gene ID" value="FFONT_0131"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0131"/>
    <dbReference type="eggNOG" id="arCOG04059">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_184178_0_0_2"/>
    <dbReference type="OMA" id="WEEAYEF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="79" mass="9420" checksum="2C3B27DB96749CFA" modified="2012-06-13" version="1">MSETKNKVRSISVVKVKDREIPIDERLLKVLRKYVYTQMTLEELAKEIGLNGWEEAYEFVKNAPAWLMWTPFTLWEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZG7</accession>
    <name>H9ZZG7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0132"/>
    <dbReference type="EnsemblBacteria" id="AFH42124">
        <property type="protein sequence ID" value="AFH42124"/>
        <property type="gene ID" value="FFONT_0132"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0132"/>
    <dbReference type="eggNOG" id="arCOG00452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095961_0_0_2"/>
    <dbReference type="OMA" id="VAPDIWI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="222" mass="24857" checksum="3AC5FE0EC7D92100" modified="2012-06-13" version="1">MSAIDKFGKRWSPQDSEGMWSKIKDRIVPPPPVRYRITMALFKIRIEKNKLEYTLNKLQERANGLFEKVVDAQVKKDSERAAMYANEVAEVRKVAKTIMSSIFALERIGLRLETVRDVGDLVSAMGPVVGVVKEVRNNLMGIMPEVAFELGEVDEILQSTVTELGEFTGIQMNNIYVTDEAKKVMEEAATIAEQRMKEQFPELPGGSMNLPAPPSANASDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZH2</accession>
    <name>H9ZZH2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cationic amino acid transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0137</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="245" mass="26618" checksum="F901C401F8ACD106" modified="2012-06-13" version="1">MKVNIVRFAVFTALVYVFTVVVQFAQPFTGGYFNLGEAAIYVCALISDPLTTGLAGGIGSALADATTGYGIFAPATLLIKFTEGYVASLLFKKMGRSNSSIANWLVSLIYFVAISAIGIKFFSGNLTLSLSSYSFSFNIPWEFWVLVGAIIMIIPFIIERRTKAGARYASLLLAGMIMVTGYFLYEFFISNPLTGRPSIAAVFEVPVNFGQALVGAAVAIPVYSFLRKGGYIEDEEDKSEDKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZQ2</accession>
    <name>H9ZZQ2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0218"/>
    <dbReference type="EnsemblBacteria" id="AFH42209">
        <property type="protein sequence ID" value="AFH42209"/>
        <property type="gene ID" value="FFONT_0218"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0218"/>
    <dbReference type="eggNOG" id="arCOG10315">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1318483_0_0_2"/>
    <dbReference type="OMA" id="TIASCEW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="230" mass="26626" checksum="3F03267D88E8A678" modified="2012-06-13" version="1">MASLKEILNSYLNKIPGIREYCDKVLKSDRWGGSALMMVIDASFTSTGLNYFNSILPRALEFKEKFVDAGKIKGLRDLAGADIDNLRAVWKNERSWNVAKEIAFYLSSINREDREALRLWAKSAVLEKWREDLIGRMKGMGIVTFQYLRMMGGVDTIVPDRVVKRFLNETLYKSGEIAEINTKRDIEFVREAERIAISYGYRPIELTWTAWLAQFGEDKIKKYTELLLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZS7</accession>
    <name>H9ZZS7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0243"/>
    <dbReference type="EnsemblBacteria" id="AFH42234">
        <property type="protein sequence ID" value="AFH42234"/>
        <property type="gene ID" value="FFONT_0243"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0243"/>
    <dbReference type="eggNOG" id="arCOG05960">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_907940_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="311" mass="35616" checksum="D3CAFCB6C90D6AC0" modified="2012-06-13" version="1">MQESKHGASVNFDEKETISILNDAVKKSKEIFNRVFDFLKEGNIIISYSGYGVIPATIFFNYLRVLTQEARFELVPSTELYLNVIPYRESTFKIFYIMASLKERNQFARLASSSSVMLVPSLFLIPYIDDPVISRWINEENSIEIDARENQILYSSILASLLGIEVAKELTNRSDMRISNAKRDLESLSEGFSFISERYAEYLESIKELESSGESCDVIYTPSLEPGAIYLMYILQEKGIACRLLRGDIAIGMQDIQRRNILLSTTVEEDIAKEIMFRFKLNSNEKSIKIVFNTDPLLAQLYSVILFSFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZS8</accession>
    <name>H9ZZS8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="3">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="3">MTA phosphorylase</shortName>
            <shortName evidence="3">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtnP</name>
        <name evidence="5" type="ordered locus">FFONT_0244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0244"/>
    <dbReference type="EnsemblBacteria" id="AFH42235">
        <property type="protein sequence ID" value="AFH42235"/>
        <property type="gene ID" value="FFONT_0244"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0244"/>
    <dbReference type="eggNOG" id="arCOG01327">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_2_2"/>
    <dbReference type="OMA" id="ADPFCPE"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018099">
        <property type="entry name" value="Purine_phosphorylase-2_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01240">
        <property type="entry name" value="PNP_MTAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="3">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="279" mass="31311" checksum="164B23F231F61DDC" modified="2012-06-13" version="1">MENWLNKTSSKIKEKADIAIIGGSGLYSAEFLEDAKELLINTPYGAPSDAFTIGTLKGKKVAFLPRHGKGHRIPPHKINYRANIWAIKQLGAKWVLSVSAVGSLRTDVKPGDFIVPDQFIDFTKSREYTFFDGPRVAHVSMAYPFCESLRRKVVETARKLNINIHTKGTYVCIEGPRFSTFAESRIWKEVFKADIVGMTLVPEVNLACEMELCYATLAMITDYDVWAERPVTADEVERVMSENVKKAREILYNLIPELPENPEENGGCSCCRSLNTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZS9</accession>
    <name>H9ZZS9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0245"/>
    <dbReference type="EnsemblBacteria" id="AFH42236">
        <property type="protein sequence ID" value="AFH42236"/>
        <property type="gene ID" value="FFONT_0245"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0245"/>
    <dbReference type="eggNOG" id="arCOG00040">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080904_0_0_2"/>
    <dbReference type="OMA" id="VVYPWNF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="18"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="224" mass="25910" checksum="357B60F76CF5E490" modified="2012-06-13" version="1">MVKIPIKLVTWSEVESWSRDLARKIIDSGYQPDVIIAIARGGVVTARILCDYLGVLDLLSIKIEHWIETAAHTENATVKYSFNTDLSSKRVLLVDDICDTGKSIVVAKEHITEKSRPLEIKTATMQYISSVAKYKPDYYIDDVKDWIWYLYPWNYMEDSINLVKKILQSDPFRKWSVDEISKGFKEAYGIDPPIELNQVIEEGIRRGIFYHENGEVKIKKQYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZU3</accession>
    <name>H9ZZU3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0260"/>
    <dbReference type="EnsemblBacteria" id="AFH42250">
        <property type="protein sequence ID" value="AFH42250"/>
        <property type="gene ID" value="FFONT_0260"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0260"/>
    <dbReference type="eggNOG" id="arCOG01618">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_2_3_2"/>
    <dbReference type="OMA" id="HVDREGT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="16"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="318" mass="36120" checksum="A3DCD07815FE6E0F" modified="2012-06-13" version="1">MEYRSLGSTEEKISAVSLGAWQFSESWGLLDYEMIKKIISTAVDNGINMIDTAIAYGRGKSEDFVGRALEELNLKEKVFVATKIPGEMLGYHDVLRAVRGSLRRLRKESIDLLQVHSPPLWNNIPTCEYMRALEKLVIQGLVRYIGVSNFPSILVEEANFCLSREEVVSNQVRYNLIERDAEKEIIPHALQNDMSIIAWSPLAKGALSGKYTAENLPKFSDVRQNEPIFYPENFKNIMPLIDLVKGIAEKYGKIPSQVSLNWLLTSYDNVIVIPGAKNPEQVIENVGAADWKMSYDDWLLLEEESRKITIYRSLNVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZU7</accession>
    <name>H9ZZU7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0264"/>
    <dbReference type="EnsemblBacteria" id="AFH42254">
        <property type="protein sequence ID" value="AFH42254"/>
        <property type="gene ID" value="FFONT_0264"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0264"/>
    <dbReference type="eggNOG" id="arCOG04165">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151699_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="141" mass="16624" checksum="916045EE47813EF7" modified="2012-06-13" version="1">MAILYILVFQYFSWKGKTMPTVHLSISDKLYDELREIAEEYGIQITDLIKVFIKNNLKAARRGTLSPDNEDTEKLEELEEKIEQISSQIIQLNKFTERQLKIQNSMIKALEEKVSNLELIIDELEEKMDNEKPYIEPEIMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZV4</accession>
    <name>H9ZZV4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutamine amidotransferase, class II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0271</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0271"/>
    <dbReference type="EnsemblBacteria" id="AFH42261">
        <property type="protein sequence ID" value="AFH42261"/>
        <property type="gene ID" value="FFONT_0271"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0271"/>
    <dbReference type="eggNOG" id="arCOG03639">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_985544_0_0_2"/>
    <dbReference type="OMA" id="PAWEDPT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="282" mass="32691" checksum="6948E49908C15EC6" modified="2012-06-13" version="1">MFGFIGDPGFEDTLYKPTLHAFVSSSYEDPYAANIFKRANFSHKEGWGVFTALINGRKVSYSIRKSLHPVYIDKPNDKLLNSEDERYYRPFAVKIFHARATSEKSTVNILNVQPFEFMTTSGSRLIIAHNGAVDKQKLIGMIDEKESYKKIFEKYSDTYVMGKYLSSIIQDDIKHEQIKNLKEFTLSALNISLVLLNEEKIQVVFGNYYVNDEEKDYYKLYVKNLRDALVFSSSTAVDFYLSADDKQNSGWFTLNNGDFYKFEVNYSKKIPKLEDLTVFNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZX2</accession>
    <name>H9ZZX2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Like-Sm ribonucleoprotein, core</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0289"/>
    <dbReference type="EnsemblBacteria" id="AFH42279">
        <property type="protein sequence ID" value="AFH42279"/>
        <property type="gene ID" value="FFONT_0289"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0289"/>
    <dbReference type="eggNOG" id="arCOG00998">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076902_11_0_2"/>
    <dbReference type="OMA" id="QSDGTMN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="LSM_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="PTHR11021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0543">Viral nucleoprotein</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="17"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="89" mass="9988" checksum="90160921E4130E9F" modified="2012-06-13" version="1">MYKGANLMSSKTQLPLKYLQDAKGNNVLVKLKDGGEYIGELDFSDSTMNVILKNCTEVKERTGEPKAKYGTILIRGSQILFISLEHTQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZY5</accession>
    <name>H9ZZY5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein FFONT_0302</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0302"/>
    <dbReference type="EnsemblBacteria" id="AFH42292">
        <property type="protein sequence ID" value="AFH42292"/>
        <property type="gene ID" value="FFONT_0302"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0302"/>
    <dbReference type="eggNOG" id="arCOG01336">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095686_1_1_2"/>
    <dbReference type="OMA" id="RGCIGFP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00645">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023472">
        <property type="entry name" value="Uncharacterised_MJ0810"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="12"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="206" mass="24031" checksum="427997B5590DDF08" modified="2012-06-13" version="1">MKQIEPEELTLEDGRILVKKARESVEKAFIYEEAKINDVPEKLRRPGAAFVTINIIKNRKKELRGCIGYVKPVYPLIQTVIEVAREAAFNDPRFPPLQRREYPFTHFEVSVLSGMRELPRDPEERLKSIVMGKMGLMVVRGIFSGLLLPQVPIEEGWDKETFLEYTCYKAGLEGSCWKDEKTEFYYFVARVFEEKYPFGEIIEKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A015</accession>
    <name>I0A015_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine protease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0332"/>
    <dbReference type="MEROPS" id="S16.A12"/>
    <dbReference type="EnsemblBacteria" id="AFH42322">
        <property type="protein sequence ID" value="AFH42322"/>
        <property type="gene ID" value="FFONT_0332"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0332"/>
    <dbReference type="eggNOG" id="arCOG01937">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027628_0_0_2"/>
    <dbReference type="OMA" id="YIANQAT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="638"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="56"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="670" mass="73689" checksum="310384E56F1DCE9A" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A018</accession>
    <name>I0A018_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="8">AdoMetDC</shortName>
            <shortName evidence="8">SAMDC</shortName>
            <ecNumber evidence="8">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="8">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="8">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="8" type="primary">speH</name>
        <name evidence="9" type="ordered locus">FFONT_0335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="8">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="8"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0335"/>
    <dbReference type="EnsemblBacteria" id="AFH42325">
        <property type="protein sequence ID" value="AFH42325"/>
        <property type="gene ID" value="FFONT_0335"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0335"/>
    <dbReference type="eggNOG" id="arCOG00279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125470_2_1_2"/>
    <dbReference type="OMA" id="HTWPEKG"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006557">
        <property type="term" value="P:S-adenosylmethioninamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017716">
        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="1 8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 8" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="8" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023457362" description="S-adenosylmethionine decarboxylase beta chain" evidence="8">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023457361" description="S-adenosylmethionine decarboxylase alpha chain" evidence="8">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="8">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="8">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="8">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="8">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="8">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="130" mass="14461" checksum="904C233E9B316DD3" modified="2012-06-13" version="1">MESGLLIKENIRENVSVKVYGSHIYGNLKNCNRAKLSDEGELKNIVANAAKIGKMTMLDLRSWKIGEGVSVVAVILESHITVHTWPEYNFATVDVYSCGTHTNPKAAFEYIARELEAEEVEYGEADRSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A034</accession>
    <name>I0A034_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH-type transcriptional regulator lrs14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0351"/>
    <dbReference type="EnsemblBacteria" id="AFH42341">
        <property type="protein sequence ID" value="AFH42341"/>
        <property type="gene ID" value="FFONT_0351"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0351"/>
    <dbReference type="eggNOG" id="arCOG02242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150444_0_0_2"/>
    <dbReference type="OMA" id="KESIRCC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="132" mass="15461" checksum="AA605F39066B3CBE" modified="2012-06-13" version="1">MTSDELKEEEIKLPSGKELTLYELVKFCYDFSETDLMILFKIIDKKTTIEELSNDLKLSKATISRSLTNLLNLGFVVRNREIENYGVGRPKYTYYSSKEIIESKLRKDMDKCAKIIRDFIGKILESKELKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A056</accession>
    <name>I0A056_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0373"/>
    <dbReference type="EnsemblBacteria" id="AFH42363">
        <property type="protein sequence ID" value="AFH42363"/>
        <property type="gene ID" value="FFONT_0373"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0373"/>
    <dbReference type="HOGENOM" id="CLU_1096684_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="253" mass="29772" checksum="117A53365F7830C4" modified="2012-06-13" version="1">MIFINENILKLSYRRKSSLLSGFYLFILFALNALFFGYVGIVDLKYREIDDKAFYCFIPIILILSIYSYFQNEIIEIVNIIIGAFLFIFAFFMSRSGFIGSADAFITSYVFFLNPYVLLIRHYVMPAGIFIIITSLLLSLLLIFKNIIINLKRVKYFRDITNGLGLLVKIYYFLFCETLNKEEFKKKKFYFVVATKSKKRIYANVEKEPFSFEEKGIKTDWIIAMYGIPLGFFIFLGLLLTYMMIFLKIILVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A060</accession>
    <name>I0A060_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase S26B, signal peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0377"/>
    <dbReference type="MEROPS" id="S26.017"/>
    <dbReference type="EnsemblBacteria" id="AFH42367">
        <property type="protein sequence ID" value="AFH42367"/>
        <property type="gene ID" value="FFONT_0377"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0377"/>
    <dbReference type="eggNOG" id="arCOG01739">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089996_4_0_2"/>
    <dbReference type="OMA" id="WFPEPVI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027245">
        <property type="entry name" value="Sec11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="PTHR10806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="PTHR10806:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase_S24" evidence="4">
        <location>
            <begin position="44"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="160" mass="17582" checksum="FF7A19FEC8EEB4D6" modified="2012-06-13" version="1">MSYSNRKGFLSKYKSDMIFIIVLIILVISIRPALSEATGLSNPVAVVKGTSMLPLLKEGDIVFLIHKSPDQIKVGDIVVYERLGGGYIIHRVVAIENISGVVYYTTKGDNNPIDDSALGQFPSGLGITYDRIIGVVWSPDNRTFVIPYLGYVTIFIESIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A082</accession>
    <name>I0A082_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribonuclease</fullName>
            <ecNumber evidence="8">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FFONT_0399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="8"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0399"/>
    <dbReference type="EnsemblBacteria" id="AFH42389">
        <property type="protein sequence ID" value="AFH42389"/>
        <property type="gene ID" value="FFONT_0399"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0399"/>
    <dbReference type="eggNOG" id="arCOG04121">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_0_4_2"/>
    <dbReference type="OMA" id="REECRFF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004649">
        <property type="entry name" value="RNase_H2_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00729">
        <property type="entry name" value="TIGR00729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_HII" evidence="9">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="200" mass="22846" checksum="5DCF7286D627DB4D" modified="2012-06-13" version="1">MKFLPITLGIDEAGRGCMIGSMFVAGVVIDDRAEKVFKKYGVKDSKKLSKNKREKLYDIITSNALWFEVVEVTPLEIDNQNINYLTIRAMRKIANDATKEIKYLNRIIADIVGKGDFKLVESDNIEQLVLKKADENFIAVAAASIVAKVQRDRALEQIRNNFGLIGSGYPGDKKSVEWLKLHYSKIPREYIRTKWKTFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A088</accession>
    <name>I0A088_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0405"/>
    <dbReference type="EnsemblBacteria" id="AFH42395">
        <property type="protein sequence ID" value="AFH42395"/>
        <property type="gene ID" value="FFONT_0405"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0405"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_2_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="258" mass="28672" checksum="37034BEA6523EC9E" modified="2012-06-13" version="1">MDMNLRNKKIIILAGSTGMGFEITKNLVNEGAKVVFCSSNENNLKRAISLLGNPINLKGELCDLSSTNSIKNFFEKAKEYLENFDGMVYNTGGPKTGNINSLSEEDYYYAYKLLSESAFVSTKEFLKYANKGASVVYMTSTAVKEPIYNLLLSNTMRLTVIGLAKSLSREYSDFARFNVVMPGYILTEKLKQLLEEEAKEKATTFDSIVSQYIKEIPMKRLGDPKEVANLVLFLLSDLSSYINGVAIAVDGGMLKSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0B3</accession>
    <name>I0A0B3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0430"/>
    <dbReference type="EnsemblBacteria" id="AFH42420">
        <property type="protein sequence ID" value="AFH42420"/>
        <property type="gene ID" value="FFONT_0430"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0430"/>
    <dbReference type="eggNOG" id="arCOG04291">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1192595_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002763">
        <property type="entry name" value="DUF72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036520">
        <property type="entry name" value="UPF0759_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30348">
        <property type="entry name" value="PTHR30348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01904">
        <property type="entry name" value="DUF72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117396">
        <property type="entry name" value="SSF117396"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="240" mass="28179" checksum="437C5B583C991D9B" modified="2012-06-13" version="1">MKRVFSLVDVVEIQKSFYDLLSDKEISNILKNKRNENKITLKCWQVITHPSTSPTWKKMKNKINGEINNYGYLKPTKENFEAFSKVVDQARKLNAEVIVLQSPPSMPYDEYTKDRISSFFKEITSIVEKNIKIAWEPRGKYAEDDSFLEKIENEKVEIVTDALRRGKIFYEHFLYIRLHGLGGKRETNYKYKYTDEDLISLSKLIGKAIVHNKNIYVLFNNIFMLEDAVRFKKLMTGAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0B6</accession>
    <name>I0A0B6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S3Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Ribosomal protein S1e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps3ae</name>
        <name evidence="5" type="ordered locus">FFONT_0433</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0433"/>
    <dbReference type="EnsemblBacteria" id="AFH42423">
        <property type="protein sequence ID" value="AFH42423"/>
        <property type="gene ID" value="FFONT_0433"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0433"/>
    <dbReference type="eggNOG" id="arCOG04186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062507_1_0_2"/>
    <dbReference type="OMA" id="GQNAYTK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00359">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030838">
        <property type="entry name" value="30S_S3Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_S3Ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_S3Ae_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="214" mass="24527" checksum="5CEE581EAE9E0B15" modified="2012-06-13" version="1">MSSVKGKRRELKETWKMKKWYEVIAPSVFGEVSIGSIPALTPEQLIGRTVEATLYDITGDYTQVHIKLNFQIIKVEGHNAHTRFKGHELARDYIKVLTRRKSSKVQGIFNVETKDGYKLRIIAITFTSYKANTSQKRAIRKIMEKIITERIKEKSFDEVIQLLVGNDLSTEIFSEAKKIYPIRKVEIYKSKLLFIPGPHGPEKATITSSIKANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0C8</accession>
    <name>I0A0C8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translation initiation factor IF-2 subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0445</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0445"/>
    <dbReference type="EnsemblBacteria" id="AFH42435">
        <property type="protein sequence ID" value="AFH42435"/>
        <property type="gene ID" value="FFONT_0445"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0445"/>
    <dbReference type="eggNOG" id="arCOG01563">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027154_0_1_2"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022424">
        <property type="entry name" value="TIF2_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03680">
        <property type="entry name" value="eif2g_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="8"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="416" mass="45658" checksum="B04AA84B1D793342" modified="2012-06-13" version="1">MAYEKKEQPEVNIGTAGHVDHGKTTLVYSLTGIWTSKHSEELKRGMTIKLGYADGGIYRCSNCPFPEEYQPLPECKECPSGSEPELLRRISYVDAPGHEILMTTMLSGAAIMDGALLVIAANEKCPQPQTFEHFKALEIIGIKNLIIVQNKVDVVSRERARESYNEIKRLIEGTWAENAPIIPISALKGANIDVLMAAIQKYIPTPERDLTKPPLMHIVRSFDVNKPGTPPEKLAGGVVGGTLSQGELKIGDEIVILPGMKVKKSGGREEYQAIYTEVTSLRFGEIEVEKALPGGLLAVGTKLDPSITKRDQLIGNVLTIPNNKLPIIDHIEMEYHLLERVVGAKEFITARPIQAKERLMITIGTALTKGVVERVSSNVIEISLSKPIVGISGSRAVFSREINGKWRLAGWGILKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0D9</accession>
    <name>I0A0D9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isopentenyl phosphate kinase</fullName>
            <ecNumber evidence="3">2.7.4.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FFONT_0456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + isopentenyl phosphate = ADP + isopentenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:33963"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:65078"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isopentenyl phosphate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.26" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0456"/>
    <dbReference type="EnsemblBacteria" id="AFH42446">
        <property type="protein sequence ID" value="AFH42446"/>
        <property type="gene ID" value="FFONT_0456"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0456"/>
    <dbReference type="eggNOG" id="arCOG00860">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070213_0_0_2"/>
    <dbReference type="OMA" id="HHNASEH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102043">
        <property type="term" value="F:isopentenyl phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024192">
        <property type="entry name" value="Fosfomycin_R_FomA-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF1">
        <property type="entry name" value="PTHR43654:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016496">
        <property type="entry name" value="Kin_FomA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="6"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR016496-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="264" mass="29106" checksum="71869F5A0DEE6576" modified="2012-06-13" version="1">MKVVIKLGGSLITDKSKPYSFRKEVVIRIAKEIKRAIDEKIDLVVIHGGGSFGHVEAKRAIDIYGRISNETISPIAFSMQELNYMMTSILVSNRIKAVSFPPHSLCVNLCNIGERFSCDLKIVKTAIEKGSVPILFGDIVYGDNFCDPAIISGDDLALMIGSYINAERIIFFTDVDGVFLELGHPETILKEIRLNEIDSVIKKASIYNNVVDVTSGLLGKLKKTYQYLSTSSSIKEVWISNGLIEGNIYNLISGKTVNGTKIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0K3</accession>
    <name>I0A0K3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl2</name>
        <name evidence="7" type="ordered locus">FFONT_0520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0520"/>
    <dbReference type="EnsemblBacteria" id="AFH42510">
        <property type="protein sequence ID" value="AFH42510"/>
        <property type="gene ID" value="FFONT_0520"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0520"/>
    <dbReference type="eggNOG" id="arCOG04067">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_0_3_2"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_A">
        <property type="entry name" value="Ribosomal_L2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_L2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L2_C" evidence="6">
        <location>
            <begin position="92"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="246" mass="26729" checksum="4412DD6A58F475E3" modified="2012-06-13" version="1">MENMGKKIRQQRAGRGSPTFRSRKHLHEAPAAYPAIKEDETFKGHIVEIIHDPGRWVPLAKVKLENGVEFYTIASEGSYIGQEIEIGPNAKPVNGNILPLQSIPEGTQVFNIEIKPMDGGKLVRTGGGYAQIISKGVNTVTVVLPSGKSKEIDGRSRATIGVAAGGGRIEKPLLKAGNSYWKWKPKARKYPKVRGVAMNVVSHPFGGGHHQSESKPTTVSRNAPPGRKVGHIAARRTGRRKGKVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0M4</accession>
    <name>I0A0M4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0541"/>
    <dbReference type="EnsemblBacteria" id="AFH42531">
        <property type="protein sequence ID" value="AFH42531"/>
        <property type="gene ID" value="FFONT_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0541"/>
    <dbReference type="eggNOG" id="arCOG00238">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_7_0_2"/>
    <dbReference type="OMA" id="NFSICLM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030676">
        <property type="entry name" value="CitT-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42826">
        <property type="entry name" value="PTHR42826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002457">
        <property type="entry name" value="DASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="477" mass="52005" checksum="B9871930DF3C9A2F" modified="2012-06-13" version="1">MVVLVDREKLLKAIIPIIIGIIIAIIPHPSALTSNAWYYFALFATVIAATILEPMPIAAISLIGVVVAVVARLVYSSPSSSISWGLTGFSNSIVWLIFAAYLFALGYSKTGLGRRIALIFIKYLGKKPLGLGYAIALSDLVLAPFMPSNTARSGGTIFPIVSNIPPMYGSSPREGTEKKIGSYLMWTAFAATCITSSMFLTGLAPNVLVQSLAAKQGIQFSWITWFIGFAPVGIFLFIITPYLIFKIYPPEIKESPEAPKWAQEELNKMGKIKGREIAFLIEVILALVLWIVGSNYIDATAVALLVVALSLLSNVYSWKDVLTYESAWNTLVWFATLFTLADGLSRVGFVSYVGKEIATSIGWMSPTIALIVIVSLFYWLHYMFASLTAHATALFPIFLATAMGISGMNPVVAAYALSYTLGIMGIISPYATGPAPVYYGSGYIKGNDFWKLGLIFGIIYYVIFIAIGMPWLLFVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0N4</accession>
    <name>I0A0N4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="6">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FFONT_0551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0551"/>
    <dbReference type="EnsemblBacteria" id="AFH42541">
        <property type="protein sequence ID" value="AFH42541"/>
        <property type="gene ID" value="FFONT_0551"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0551"/>
    <dbReference type="eggNOG" id="arCOG01599">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_0_0_2"/>
    <dbReference type="OMA" id="PEWCPGC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011896">
        <property type="entry name" value="OFOB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032686">
        <property type="entry name" value="PFO_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12367">
        <property type="entry name" value="PFO_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02177">
        <property type="entry name" value="PorB_KorB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="9">
        <location>
            <begin position="50"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PFO_beta_C" evidence="10">
        <location>
            <begin position="200"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="311" mass="34478" checksum="B358E1DBA908DAB9" modified="2012-06-13" version="1">MEHNPGKYRTDLWIDWCPGCGNFGILASEIKALEELNLEPSKIAIVSGIGCSAKIIHYINANGVHSLHGRAIPFAIGIKLVRPDLTVIVNGGDGDLLGIGAGHFVALGRRNLQMTIILHDNRVYGLTKGQAAPTLPLGVKTKALAIPNIYTDINPIALAISSGYTFVARAYAFDSEHLKEIIKKAIMHRGVSLVDVLQPCVTFNDIHTADYFKKKIYKLEDEGWDPVVRDPKDIEEKALNAIRKSFEEEKIPVGIFYENSLLPTYEERLKNVIKSYPSISPGTTKIEVNGKSIFDRKLFESVFSDFIIDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0P8</accession>
    <name>I0A0P8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="2">6.3.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0565</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
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    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1163730.FFONT_0565"/>
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    <dbReference type="eggNOG" id="arCOG00639">
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_2"/>
    <dbReference type="OMA" id="EPLFMTD"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
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        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
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    </dbReference>
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        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="6">
        <location>
            <begin position="54"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="7">
        <location>
            <begin position="163"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="336" mass="37119" checksum="95DFE0872699D887" modified="2012-06-13" version="1">MRYKDAGVDLQKHNNIHEIAKMHVFKLSNELGSIIGGVGGYSPYMRIFGRELTLHVDGVGTKVQILSKFKKLDVAGWDCIAMNANDMACEGFRTLAFSDYIAMDSADEEGFEEIIKGMIDALRKVKAPLLSGETAIMPGIVSGKDVVCFALGSREIEFKNKAKEGDVVVGVESNGLHSNGYSLVRKVVEEKIGGYDREIEGLDLKVELTKPTFLYYNLIIESIKKDLINSAAHVTGGGWKKLKRVLGEVLDMNLSPPPPPQIFEVLLKYGEIPIEEAYSVFNMGVGLVFTTEKESLEELIELIERHSFRPVILGEVSKGSGLLKIEANKYGKNFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Q0</accession>
    <name>I0A0Q0_FERFK</name>
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            <fullName evidence="6 9">Adenylosuccinate lyase</fullName>
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        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FFONT_0567</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="5 9"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0567"/>
    <dbReference type="EnsemblBacteria" id="AFH42557">
        <property type="protein sequence ID" value="AFH42557"/>
        <property type="gene ID" value="FFONT_0567"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0567"/>
    <dbReference type="eggNOG" id="arCOG01747">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_030949_0_1_2"/>
    <dbReference type="OMA" id="ASSCEKI"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
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        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
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        <property type="entry name" value="L-Aspartase-like"/>
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        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
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        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7 9" id="KW-0658">Purine biosynthesis</keyword>
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    <feature type="domain" description="ADSL_C" evidence="10">
        <location>
            <begin position="362"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="451" mass="51240" checksum="A03929B101BB0084" modified="2012-06-13" version="1">MREMNKDVICVFDWRYGSDEMREIFSLKNIVKTYIKVENALMNGLIDAGFAPPACRDSVVKCGGNISPEEVYEKEKVLGHDIASLTYILGEVCGECGKYVHLGATSYDIVDTTWSLLIKQADDVLISKLKKIIEKLIELAKNYANYVEPGRTHGQHADPITFGFKFANYIYELTRSLERIKDAEKRTVKIKMSGAVGTMAAWNGKGLEIEESVSKQLNIEPHLISTQVAPRDGLAEVISSLAILASQLDRFALEVRELSRTEINEMYEYAERIGSSTMPHKRNPVTAERISGLAKIMRAFVISTLENIPLMHERDLTNSSSERVILPHAYLTMDQMMDDMIKLLNTLYINTEAAKKNLEITKGATLSEKLMLLLVERGFARHEAHKKVMQISRALKEGESLIDAALRDEDISKLFTREELERELKPEKYLGNYRELIERTISYAEKRLHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0S0</accession>
    <name>I0A0S0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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            <end position="93"/>
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            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
    <sequence length="106" mass="11906" checksum="8C16A497F5A0CD35" modified="2012-06-13" version="1">MVKMFKYYVCEKCGKGYYPKKVRCRCGSTSFKEVIDENAEGKIYTYTIIYVPPKGFTPPIAVAIAEYNGMRFLGKYNGDPGKIKIGEKVRLDTSEDGSILISPIES</sequence>
</entry>
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                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </feature>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="380" mass="40776" checksum="42B16067623839C5" modified="2012-06-13" version="1">MKRLVLKSFGMRGFAIEVLSLFFILIFSYSLISITSSVAYAPFYIAEAGGGGELLYSSSSTLVYTGLVPSSLYTYLLNVTGGQGISPEVSVPILIDGKAVLARGIEVGRFVKCTDLKVIEGGLNLSNGGALVGERVAEGFKLKVGDQFTALSAMSNRSLTFFVVGIISGSAVSDEVLISIDDARYLRGINDEMLSYIRVCSQSPEVMNAIGEIGNSSQEREGISVPSWLLSLASRFSVSSTLSGYSTRISKNIEEAERVTLIASLSVSVALSSILAFSLSGASISSSSSAIKALRDMGMRKRDVLKSVAVEKSIAFSSSLILSIASYLLMEKMGIIYAYVLEHRIPPSLSWIDAMIYTIAVFSIYIAISLRRAEVILNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
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    <name>I0A0W3_FERFK</name>
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        <submittedName>
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    </protein>
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Glyco_trans_1"/>
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        <property type="entry name" value="Glyco_trans_4-like_N"/>
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    </dbReference>
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        <location>
            <begin position="9"/>
            <end position="181"/>
        </location>
    </feature>
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        <location>
            <begin position="190"/>
            <end position="330"/>
        </location>
    </feature>
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        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="332" mass="37855" checksum="DC57B9A59FA19BD4" modified="2012-06-13" version="1">MSPSYYPHIGGVEYVVKSIAERLARMGHDVIILAGKPDSEKPYEEVVNEVNVIRWPVWSPSGAYHIPKMHSKLDKQLRDVLNYLDVVHVHSAHSIFSVYTGLAVKKLKPDIRLVFTPHYHGGGHSFTRNALWFLWRRRMSKLVEISSMVHAVSKPEASRILNHYPKANEKLVVIPNGIEEDVLEYKWIGKDSDYMIYAGRIEKYKNLEKAIEVARQLGLKLLLIGNGPYKKRLEAKAERTYPNAVAFKNFLPRAQYLDLLSKARYVINPSEREAFSIFIAEALAMGVPAIISRNIAENLDVNGSEMVEGLVVVEKGLVETWNNVLRKYLSIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0W4</accession>
    <name>I0A0W4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0631"/>
    <dbReference type="EnsemblBacteria" id="AFH42621">
        <property type="protein sequence ID" value="AFH42621"/>
        <property type="gene ID" value="FFONT_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0631"/>
    <dbReference type="eggNOG" id="arCOG01408">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1574909_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="169" mass="18373" checksum="05698D8D717D01C8" modified="2012-06-13" version="1">MDIGAIYFTILATREELNLRAVIVGPGDQRLYRELADKLGISNKVLFTGFVDEDTKIGAIDASIALTLPSLSNYVEAYSLAITEAWAREKPVIASATGEIPYRVKHMINGLVVPPRDPKALAEAIKILIQDRGLGEKLGEIGKSGVITWSNVVDMLLKIYGEVFNASKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A102</accession>
    <name>I0A102_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protoheme IX farnesyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FFONT_0671</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0671"/>
    <dbReference type="EnsemblBacteria" id="AFH42659">
        <property type="protein sequence ID" value="AFH42659"/>
        <property type="gene ID" value="FFONT_0671"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0671"/>
    <dbReference type="eggNOG" id="arCOG00479">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1357865_0_0_2"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFH42659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="201" mass="22342" checksum="6CEE51DF50668B5C" modified="2012-06-13" version="1">MKMKAIFADLFKPIQTAFLVLSGLISYTVSSDGSPDWRVLLMLTFSLYFTISGTTGLNMYLDRDIDSMMERTKKRALPSRKLNEGDAVYASALFLSIGLLLFASINWGVFIAGLLGAIVDLAIYTRMLKRRTPPQRHFREHSWGNARAGGLARTPQLPHNRRDPHSLSSCPMVSEPHMVHSLILFGGLHKGQSPHAPRSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A126</accession>
    <name>I0A126_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative, serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0695"/>
    <dbReference type="EnsemblBacteria" id="AFH42683">
        <property type="protein sequence ID" value="AFH42683"/>
        <property type="gene ID" value="FFONT_0695"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0695"/>
    <dbReference type="eggNOG" id="arCOG03871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Flagellin/pilin_N"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02537">
        <property type="entry name" value="arch_flag_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="157" mass="16066" checksum="A6873D9CDFE5F9E7" modified="2012-06-13" version="1">MITNGGNMEKRGISPIIATVILVVITIALAVGVALWMSGIIGGAGRGEQLGILPDSNMTLLSSTNNTNATIWLHVKNSGSADAQIIAVKLNGVNLPSSDIQTSAPITVKAGSDFNFIINVTSSDVGLTSFTPGTSYQVTIITSAGGSYSTQLTAISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A134</accession>
    <name>I0A134_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC-2 type transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0703</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
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    <sequence length="428" mass="47412" checksum="227154E84D6DD485" modified="2012-06-13" version="1">MRLLFLEKKELLVAIALLSLIFLTATASIMHAEQTSSYVKFFVYGETRCPYCMHQISFFNTTFSQNYYFCDISSNTTCLTNFANWLRFSNMSLSVPQTFVIYNNTNLLAIVIGDVENTTFWNLFLSSPPNQTGFPVYVATDTGEVLAGYVNANTQQQEYIIYRFILGQNVTFTTTSTLTNTTTAPANTTTSITNTTIPNSYQYSGNSFIATLVSLAASDAVNICIISVYSLLIVTIAVNKSRKRAAISGLGFALGIFTGYLALGLGLLKVISSLGTLPSTIARYILAFYGIILIIYSAYSYLTQKRNCIICKENEGKNNKSFLNIKSWMNKSPALHYILGLILSISLIPCSAGPYIVFILLLSTVSGMLTKILYLLIYDIIFVAPLLILLEIIVLTLKKVNERKVAIVRELVFIIAGLLLIVLAIRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A193</accession>
    <name>I0A193_FERFK</name>
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        <submittedName>
            <fullName evidence="3">Threonyl-tRNA synthetase-like protein (ThrS-like)</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">FFONT_0762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0762"/>
    <dbReference type="EnsemblBacteria" id="AFH42750">
        <property type="protein sequence ID" value="AFH42750"/>
        <property type="gene ID" value="FFONT_0762"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0762"/>
    <dbReference type="eggNOG" id="arCOG00401">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_712936_0_0_2"/>
    <dbReference type="OMA" id="IIYPYAH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015011">
        <property type="entry name" value="Threonyl-tRNA_syn_edit_dom_arc"/>
    </dbReference>
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        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08915">
        <property type="entry name" value="tRNA-Thr_ED"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-Thr_ED" evidence="2">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="HGTP_anticodon" evidence="1">
        <location>
            <begin position="309"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="403" mass="46592" checksum="D00871CBC1883F03" modified="2012-06-13" version="1">MGENMRILQIHAKKFSFRTVSEALQKKDETPIHELSKENVLVAFISVERGDDEKVIENATESIAEHAKKVNANSIIIYPYAHLSSNLEKPDQSIKILDELSERLKDKKLEVARAPFGWYKEFELSSFGHPLAELSREFSSAVSLQIKLSKNSYDKLVNDYLKRFGFEVYSNGFNIKEPWDSLVKEFCMLKAENEFYETLNGVTLKEGSRSFFKAKILPGNNEIFDCTMDIDFSIIRNNIKNLKLENEEGIAFYRSENVDSIPVATIINNRYFPFFNGSLFSLILDRLIELEEKKALSPYLPMLFSPYQSVILKVGNVNEEKIIEVKRLLESIGLKRVYLDLSNEKIGSKLRKWGMKWVPLVFIYGEREEETNTIILRERKTNVQYTISLSELEGAVKKFLETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1A9</accession>
    <name>I0A1A9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0778"/>
    <dbReference type="EnsemblBacteria" id="AFH42766">
        <property type="protein sequence ID" value="AFH42766"/>
        <property type="gene ID" value="FFONT_0778"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0778"/>
    <dbReference type="HOGENOM" id="CLU_2856948_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="64" mass="7301" checksum="8921EFD75EF3CCED" modified="2012-06-13" version="1">MKSKSQRIQTVKFVHIEGFQILYKFILVDASLLGSAYGLKAFESKVFGEHVYACNNILKHLRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1B1</accession>
    <name>I0A1B1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exopeptidase, family M28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42768">
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        <property type="gene ID" value="FFONT_0780"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0780"/>
    <dbReference type="eggNOG" id="arCOG02959">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035477_0_0_2"/>
    <dbReference type="OMA" id="CHPKPGA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="263"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="601" mass="67930" checksum="44EDA71C2F36713C" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1K5</accession>
    <name>I0A1K5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Exopeptidase, family M24B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0874</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0874"/>
    <dbReference type="EnsemblBacteria" id="AFH42862">
        <property type="protein sequence ID" value="AFH42862"/>
        <property type="gene ID" value="FFONT_0874"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0874"/>
    <dbReference type="eggNOG" id="arCOG01000">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_2_2"/>
    <dbReference type="OMA" id="PGMCFSV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Creatinase_N" evidence="3">
        <location>
            <begin position="15"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="2">
        <location>
            <begin position="145"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="362" mass="41106" checksum="4E414531B26D7F11" modified="2012-06-13" version="1">MKEVKRGRVKKILSYGLDSIVVTSGSNFFYLTGLKIETFERPLLLFMSEDYSFLLAPKLEMERLGDLNVTESLFYDDATDPFKIIESTPTLKNILRKGVKIGVDPNLRFSFFYKLNNIFKDVNFVDASEEIQLARMIKEEEEIKNIEKASNILSKIFETAQESISPGISEAEVRFNLMKKASELGASSYDFIAIQSGENTAIPHHEFSSRKIRRGDLIVIDAVVSYNWYNADLTRVFSLGKPNEEVLSIYSFVRQAQKIGIESSISNVTAKSIDEKVRNYFKEREIDQFFIHRTGHGLGIDAHEKPFISSTSNDVIENGQVFTIEPGLYFPGKFGIRLEVDVVIKEGKPHIIGDFPLDIVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1K9</accession>
    <name>I0A1K9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxal phosphate-dependent aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0878"/>
    <dbReference type="EnsemblBacteria" id="AFH42866">
        <property type="protein sequence ID" value="AFH42866"/>
        <property type="gene ID" value="FFONT_0878"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0878"/>
    <dbReference type="eggNOG" id="arCOG00915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OMA" id="NLMPGVQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="446" mass="50185" checksum="8619402A6C0B234B" modified="2012-06-13" version="1">MENSIFDRYWKSISRASSYKYFPLIVKKIEGSRIVDVNGKEYIDFLSSAALYNAGLNNDEVVTSLLEELKNMLHYTQYLYHEKSIKLAEILKEITPGTFEKKVAFELSGGAAVDIALRSSLYFSGKKLLGSFENSYHGTTYLSISVSGSFRPEIREKLNAYPYVYFFKYPDTFRRPRGIEPEEYGEILLGEIERTLQVDAYGKGFAAIIFEPIQGDGGVLVPPKSFIVGLRKIADEYGIVLIDDEIQTGFGRTGKMFAIEHFGIEPDIIVLGKSLGSGMPISAVIGRREILDSPEPMTYMSTYSPHYLSCIAAMAGIEYIIKNRLHDRAELMGEYLMKRLNELKDGHEIVGDVRGKGLMIGVEIVDDKDSLKPSSKKAQKIIWRAYENGLIMMTFGKYGNVLRIAPPLTIEREEIDKAVEIMEKAISDVEKGKVGDEVLSKMVAWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1N3</accession>
    <name>I0A1N3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydrodipicolinate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0902</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0902"/>
    <dbReference type="EnsemblBacteria" id="AFH42890">
        <property type="protein sequence ID" value="AFH42890"/>
        <property type="gene ID" value="FFONT_0902"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0902"/>
    <dbReference type="eggNOG" id="arCOG04374">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050509_1_1_2"/>
    <dbReference type="OMA" id="GFNWTMG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="4"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="136"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="332" mass="36309" checksum="A26FDF5518E6D242" modified="2012-06-13" version="1">MIRIKLGIYGFGAIGKLVANVALERGYEISGAVDVNKEILDKDIGEIVGKEKIGAKVTNNLNILENSDVIIHTTGSFLDSVFEQLANIIKLGLPIVSSCETLSFPYYRYPILALKLDKLASSYMIPIIGTGINPGFIFDTLVATLSSSVSLVKKIKAIRSLDASKRRESFRKKIGVGEPPEVVLEKLMKKEISGHVGYAESVYLVALSGGVNLSKVEESSELILAEDDIEQNGIKVKKGMNKGMRGYGVGYLNDKDIVRIDFQAYVGAPEFEEISIEGKDYNITWKSTGTPGDLGTVSMLLNVAEKILYMPPGLHLMTELLPFGTKFDMSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1P9</accession>
    <name>I0A1P9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetyl-D-mannosamine dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.336</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">UDP-ManNAc 6-dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FFONT_0918</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 2 NAD(+) + UDP-N-acetyl-alpha-D-mannosamine = 3 H(+) + 2 NADH + UDP-N-acetyl-alpha-D-mannosaminouronate</text>
            <dbReference type="Rhea" id="RHEA:25780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:68623"/>
            <dbReference type="ChEBI" id="CHEBI:70731"/>
            <dbReference type="EC" id="1.1.1.336"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.336" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0918"/>
    <dbReference type="EnsemblBacteria" id="AFH42906">
        <property type="protein sequence ID" value="AFH42906"/>
        <property type="gene ID" value="FFONT_0918"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0918"/>
    <dbReference type="eggNOG" id="arCOG00252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_2_2"/>
    <dbReference type="OMA" id="WDVIRCA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089714">
        <property type="term" value="F:UDP-N-acetyl-D-mannosamine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="335"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="455" mass="49493" checksum="9074D7F736B6CD5F" modified="2012-06-13" version="1">MVLLGKSRNEASNLLLNGELTVSVFGLGKMGLPLALVFASKGAKVYGVDLNENVVEMVNRGENPISFEPGVGELLEKAVKEKRLTAVTDGALASSKSDLIVLLVPVYANAKGIRMELMEKAIDEVSNGIRKGAIVVTETTLPPGTTESFIPKIENVSGFKAGIDFGIAHAPERTMSGRVIKDITESYPKIIGAINEATLEPLIGIYSAINKKGVVPVSSIRVAEAVKVFEGVYRDVNIALANELALISERLGINVNEAIDSANTQPYSHIHRPGAGVGGHCIGVYTWFLIHSFPELSKIMKIARETNDSMPLHIVELTVKALNLVRKPVNGARIIVFGLSYRGGIKETINSPSFPLINEFLKWGANVEVYDPYFSNEEIMSYGFKPFNGNFEGADAVVVVTDHPQFKEVDLRDLKDKMATPIIIDGRYIYATAKGIENFIYASPGIQIRCPKSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1R0</accession>
    <name>I0A1R0_FERFK</name>
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        <submittedName>
            <fullName evidence="3">Archaeal flagellar protein FlaI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0929"/>
    <dbReference type="EnsemblBacteria" id="AFH42917">
        <property type="protein sequence ID" value="AFH42917"/>
        <property type="gene ID" value="FFONT_0929"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0651">Protein splicing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INTEIN_C_TER" evidence="2">
        <location>
            <begin position="656"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="845" mass="95700" checksum="1B21D05BFFABBD96" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1W3</accession>
    <name>I0A1W3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphohydrolase, DHH superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_0982"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="DHH_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="240"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="335" mass="37963" checksum="DC2C9B911B47F420" modified="2012-06-13" version="1">MSELQLYTHGDLDGIASASIYIKIAKEKLSNINYSVNFVEPTNLDKALSSTISPYKSGSIIAIMDIGVNRSNFEKVLSILSELTKRFTVEWYDHHIWPKEFKDAINSIGVKLFVEEDTCAAGVVSRHAFGGLSPEDDNTRFFVDSVCSADLWKWEEWFSPFLYRILGSGDIDVGSNKWKRFLIEEFSNGRYWSDSFDDIVEKYINLELEGYNKALREVFTEQCKRINVAYLYKKPGPPNASLLGHYLLSKTGADIVVIYRESGVLSFRSKQVDVSSIARCIGGGGHKLASGAEIKLPFYYFPLKIILKPLFDYLIKKKVMKKVNYCISETDIAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Z4</accession>
    <name>I0A1Z4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_1013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PurM-like_N"/>
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        <property type="entry name" value="PurM-like_N_sf"/>
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    </dbReference>
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        <property type="entry name" value="hypE"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="172"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="352" mass="37987" checksum="6DBEB7F6119FE888" modified="2012-06-13" version="1">MKILEEGKTVKLSHGNGGPETSEILNSILFSKVEETLKRVEGGVGIDVLDDGATIPIGDLGYVVISTDSYTVKPLFFPGGDIGKLAAAGSINDVVMMGGRPVAILDSIVVQEGFEINELEKIMESFISTLKEEKVSIIGGDFKVLPREELDGIIITTTAIGIAKKPIIDRPKVGDKIIVTGNLAEHGVLISLYRLGLEDKAGNAGLLQSDVMPLSKYLLPIFEKYGEKINAARDPTRGGLSEVLNEWALQNKLIIEIDEKSIPLREPVVKYTEMLGIDPLHLASEGVAVLSVEESVSEEILDELQKNGLSDAKIIGEVKKEAKEMGIVLMKTAIGGRRVVEPPRGELVPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A204</accession>
    <name>I0A204_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Indolepyruvate oxidoreductase subunit IorA</fullName>
            <shortName evidence="14">IOR</shortName>
            <ecNumber evidence="14">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">FFONT_1023</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="18" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 14">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 15">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="14 15">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Heterodimer of the IorA and IorB subunits.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="14"/>
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        <property type="protein sequence ID" value="AFH43011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1023"/>
    <dbReference type="EnsemblBacteria" id="AFH43011">
        <property type="protein sequence ID" value="AFH43011"/>
        <property type="gene ID" value="FFONT_1023"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1023"/>
    <dbReference type="eggNOG" id="arCOG01609">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017727_0_0_2"/>
    <dbReference type="OMA" id="IGDSTFM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017721">
        <property type="entry name" value="IorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006439">
        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03336">
        <property type="entry name" value="IOR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14 15" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 14 15" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14 15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="577"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="16">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR006439-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFH43011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="636" mass="70208" checksum="35A8575EA1D4FCDC" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I0A214</accession>
    <name>I0A214_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1033"/>
    <dbReference type="EnsemblBacteria" id="AFH43021">
        <property type="protein sequence ID" value="AFH43021"/>
        <property type="gene ID" value="FFONT_1033"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1033"/>
    <dbReference type="eggNOG" id="arCOG04458">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1302582_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="211" mass="24732" checksum="FF3E6D8EB669E507" modified="2012-06-13" version="1">MAWKKIAIDRLIKNLDNIDKTYTESIAVLNKLTNHPFFLGVYLDTEHLKGTARLFPGSYIYSLIEKKKVKAGDIITLNYSNSFDEIFQLFYLKKLKIVKGKKVPPHTNRSYFLIPTTIEEITLKDGLIYLKLSIEENVWIKIENLLPPYRPVNLLIEAIISHSRLYLGISDSEEINYIKRLLSNIRRTTENERLLSYIKFIEEMIEGYEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A218</accession>
    <name>I0A218_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Metal-dependent carboxypeptidase</fullName>
            <ecNumber evidence="1">3.4.17.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_1037</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of a C-terminal amino acid with broad specificity, except for -Pro.</text>
            <dbReference type="EC" id="3.4.17.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M32 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.17.19" evidence="1"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1037"/>
    <dbReference type="MEROPS" id="M32.002"/>
    <dbReference type="EnsemblBacteria" id="AFH43025">
        <property type="protein sequence ID" value="AFH43025"/>
        <property type="gene ID" value="FFONT_1037"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1037"/>
    <dbReference type="eggNOG" id="arCOG04247">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032916_1_1_2"/>
    <dbReference type="OMA" id="EFGHALY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001333">
        <property type="entry name" value="Peptidase_M32_Taq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34217">
        <property type="entry name" value="PTHR34217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02074">
        <property type="entry name" value="Peptidase_M32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006615">
        <property type="entry name" value="Zn_crbxpep_Taq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00998">
        <property type="entry name" value="CRBOXYPTASET"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR006615-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="499" mass="58601" checksum="2FA2AAD485D13831" modified="2012-06-13" version="1">MGEVFENSVIKEIINRYKFIWSIDYAMGLLEWDMETYMPKEGIIERSIANRHLSVLEHRLLLDPELVSLVEKAKSIETLNDYEKGVVRVLDREITKAKKIPESLIAELREVTIRAHEAWVTSREKNDFSIFKPYLEKIVELEKRMADYLGYVEHPYDALIDYYEEGWTTKDVERMYDSIIPELKSILEKVMSDSRYPKCHYLESYKYDITKAVEINNRLLDILGFPRTRARIDVSEHPFTINFGIRDARITTRYEGYDIKRTIYSAVHEFGHATYELQIDESLSGTPLARGVSMGIHESQSRFWENVVGRNFAFTKIVGSLIREYFPELKNFSDEDIYYYINTVKPSLIRVDADELTYNFHVALRFRIEKMLIGNEIKVSDVPDIWNNTMEEYLGIRPKDYKSGVLQDIHWSQGSIGYFPTYSLGTIISAQVGYAIEKDLGKKLGDIIDSRNFAEIKEWLKRKIHRFGATYAPKELIRRNLNEDVNPEYYISYLKNKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A236</accession>
    <name>I0A236_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HutC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_1055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1055"/>
    <dbReference type="EnsemblBacteria" id="AFH43043">
        <property type="protein sequence ID" value="AFH43043"/>
        <property type="gene ID" value="FFONT_1055"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1055"/>
    <dbReference type="eggNOG" id="arCOG01007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013016_0_2_2"/>
    <dbReference type="OMA" id="MQGVFGN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000522">
        <property type="entry name" value="ABC_transptr_permease_BtuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30472">
        <property type="entry name" value="PTHR30472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01032">
        <property type="entry name" value="FecCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH43043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="329" mass="36486" checksum="33F45B4A9256CE0F" modified="2012-06-13" version="1">MIKKFVKLRKMIKLKFFSFIFFFAILVSSLLSLYLGSSGSIAFDEWKWENVIFQIRMYRTLTVIFTSETLAIIGLILQTIFSNPLVDSSILGISSGSSLGAVIGLLLVSRMGYSAIFIFSFIFSLLAFIVILFLSKITGYKTISMVLSGVIISTLFNSFLYLLFMTNTILARVHSVSWMFGTFEFSNSSSFYASFISFLIVFVFLYVKGPRLRQLLYGDDFAIARGADPKNLRREVLIVTSISISLISVYEGPIGFIGLIVPHIARMMLGGDISVASLGSLFISPVILLLSDVVARVLLAPSEIPIGIITSLIGAPFFLMLLVKSYRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A244</accession>
    <name>I0A244_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1063"/>
    <dbReference type="EnsemblBacteria" id="AFH43051">
        <property type="protein sequence ID" value="AFH43051"/>
        <property type="gene ID" value="FFONT_1063"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1063"/>
    <dbReference type="HOGENOM" id="CLU_3056967_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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</entry>
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                <person name="Mardanov A.V."/>
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                <person name="Kublanov I.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <sequence length="115" mass="13488" checksum="02A02DAA0485D8F1" modified="2012-06-13" version="1">MKNDEKRILELFIKEDLVVGGVLRNKILEHLIIEKNDENFLNRLEKRSFIKEVRFIDVMNIGGKNEEILVKALKANIKKELVYKELYESIVNGLKEVKNCEVLSKVWNSNEAEEN</sequence>
</entry>
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    <name>I0A286_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1105"/>
    <dbReference type="EnsemblBacteria" id="AFH43093">
        <property type="protein sequence ID" value="AFH43093"/>
        <property type="gene ID" value="FFONT_1105"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1105"/>
    <dbReference type="eggNOG" id="arCOG00492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_2"/>
    <dbReference type="OMA" id="GGCFNNY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="12"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="379" mass="42422" checksum="AF0942D76E5F4AD4" modified="2012-06-13" version="1">MSKISDLSRKREVISFAAGEPDPSVLPRKIFGELMKEVFEKVELVGNYTPADGAFELREEIAKFMKKYDDVKTDPNKIVVTIGGSQALDLLGRIFLDAGDIAISESPSYVNTLIDWKQYGARIVGVPVDDSGMITDELEKTVKKLKGERKRVKLVYTIPTGQNPSGVTMIEERRKHLLEIASQYDLILVEDTAYNHLLYEGQPPKTLRSMDKEGRVIYSGTFSKILGTGLRIGWLEGPSEVMDLIKMVKGPTDMCASTPMQYLVIESLRRGIFEDAKKKALENYKMKRDIMIKSIEEKLKGLKFTKPIAGMFILVWLKKGMDGYAFAEELLEKKGVAVVPAAAFYTDDSGKEVIRLNFSMVPPEKIEKGISSIAELLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I0A299</accession>
    <name>I0A299_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polyamine aminopropyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Putrescine aminopropyltransferase</fullName>
            <shortName evidence="2">PAPT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Spermidine synthase</fullName>
            <shortName evidence="2">SPDS</shortName>
            <shortName evidence="2">SPDSY</shortName>
            <ecNumber evidence="2">2.5.1.16</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">speE</name>
        <name evidence="5" type="ordered locus">FFONT_1118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>putrescine + S-adenosyl 3-(methylsulfanyl)propylamine = H(+) + S-methyl-5'-thioadenosine + spermidine</text>
            <dbReference type="Rhea" id="RHEA:12721"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="2.5.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer or homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.16" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1118"/>
    <dbReference type="EnsemblBacteria" id="AFH43106">
        <property type="protein sequence ID" value="AFH43106"/>
        <property type="gene ID" value="FFONT_1118"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1118"/>
    <dbReference type="eggNOG" id="arCOG00050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048199_0_1_2"/>
    <dbReference type="OMA" id="LWPGQSF"/>
    <dbReference type="UniPathway" id="UPA00248">
        <property type="reaction ID" value="UER00314"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="1 2 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="4">
        <location>
            <begin position="10"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-methyl-5'-thioadenosine binding" evidence="2">
        <location>
            <begin position="146"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>spermidine</name>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>S-methyl-5'-thioadenosine</name>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="313" mass="35878" checksum="76364EB7FF887AB5" modified="2012-06-13" version="1">MGMKKLTPWTSWYVEWIDDGDASFKAANQLYAMEKTPYQEVFVVNLLTLGKALIIDGKVQSTLFDEFVYHESLVHPPLLAHGNPERVLILGGGEGATLREVLRYKTVKKAVMVDIDEKVVEFSKKYLQEWHHNSFFDKRAEVVIEDGRKYLENAGKSDEKFDAIVIDLVDPLAGSPAVKLYTREFYQLVKGALKEGGVMVTQATSPVLYQEMFATIHSTIKSVFKIARPYAVYMRSYNGLWGFVFGSEEKDPLQLNESEVERRIRELLVNPEDLRYYDGDAHIGMFKIPKNLKQALKKYTDISTDEKPKYLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2B0</accession>
    <name>I0A2B0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNase P subunit p30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1129"/>
    <dbReference type="EnsemblBacteria" id="AFH43117">
        <property type="protein sequence ID" value="AFH43117"/>
        <property type="gene ID" value="FFONT_1129"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1129"/>
    <dbReference type="eggNOG" id="arCOG00307">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1340696_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="204" mass="23188" checksum="CD68759F321FD57D" modified="2012-06-13" version="1">MKALFADYYIFPKDEEELKKIVKVAQSLNYSLIGIDEKYSTKISSLASEQLKVLTSRRVEAFDEREAKNKLHAAGKKVSITIGVAKGASALRFFSKNKSVDIIEISPKLHRVMDKNQADLMKQGKTSIGINLGEIVRKLELIPFAEFLIKYALKYDIKIAFYSGAEKYSELWHPRSVFHLLKTFGITERVAKSIVLDMRIKNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2C6</accession>
    <name>I0A2C6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="gene ID" value="FFONT_1145"/>
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    <dbReference type="Proteomes" id="UP000007391">
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        <source>
            <dbReference type="EMBL" id="AFH43133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="47" mass="5040" checksum="96DD0313EEDD6F8D" modified="2012-06-13" version="1">MITSLSTAVKKNMLPVSVGGSLYVLSSILDTSVYKGELDKVKIPVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2D0</accession>
    <name>I0A2D0_FERFK</name>
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        <submittedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit beta</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">FFONT_1149</name>
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccaceae</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1149"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_int_endo" evidence="2">
        <location>
            <begin position="65"/>
            <end position="143"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="150" mass="17956" checksum="5EB156B230B0B88C" modified="2012-06-13" version="1">MKECTKAKYLREKRELVCYTGEKLDFYETVYMCKKGKIIITDEDQKTLEWYDIVLDRSQLENNAWILFSVYYDLRERGRILKYGPFQNSFTLYQNNKPISLVFVYEETFEFKVSTLLDLLDAAKRLNREAILAVVDKHGDVSYYTFEKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2D8</accession>
    <name>I0A2D8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-t(6)A37 methylthiotransferase</fullName>
            <ecNumber evidence="9">2.8.4.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FFONT_1157</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[sulfur carrier]-SH + AH2 + N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="9"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1157"/>
    <dbReference type="EnsemblBacteria" id="AFH43145">
        <property type="protein sequence ID" value="AFH43145"/>
        <property type="gene ID" value="FFONT_1157"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1157"/>
    <dbReference type="eggNOG" id="arCOG01358">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_4_2_2"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:N6-threonylcarbomyladenosine methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061712">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="11">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="128"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="10">
        <location>
            <begin position="363"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFH43145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="425" mass="48553" checksum="0C96A2F294199252" modified="2012-06-13" version="1">MKFFIKTFGCALNRSDSELMREILISRGFEEIDNLENADVIIVNTCTVRKDSDQKAIEYIEKVKQLNKNSKIVVAGCIPGSQPYLIKSRFPDAVLISPYETNRIVDAIFYETDFLGYEEFKRYNVPIVKTGNIAIVPLNDGCLSNCNFCITKVARRRLLSRMPKVILKAIKDLVENGVYEIQLSSQDASVYGIDFKGRPLLPDLVETINQEIKGEYMLRIAMMNPDGVKKDLENFVKIFEYEHVFKFLHLPIQSGDDEVLKIMGRDYSIEDALYVVNEFRSRIKDLRIATDIIVGHPGESEEAFENTLKVVVSGLFDRVHIAQYTPRPFTLSARMPQISDSVKKKRSSLLKEELEKVLNKKMEKYVGKIIEGVVVEKDEKRESYIARTKNYISIVLKGGKKVSLGMKVNIEITDYTPYDLRGIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2E3</accession>
    <name>I0A2E3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH_45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH43150">
        <property type="protein sequence ID" value="AFH43150"/>
        <property type="gene ID" value="FFONT_1162"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1162"/>
    <dbReference type="eggNOG" id="arCOG01055">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1375482_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038723">
        <property type="entry name" value="ArnR1-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14947">
        <property type="entry name" value="HTH_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_45" evidence="1">
        <location>
            <begin position="12"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="198" mass="22656" checksum="EB376357D37A2F9D" modified="2012-06-13" version="1">MNVISSGGDFGIKKTHLMYKTNLNSKMLQKYLDILQRNGLIIEESKGKQKIIKMTPKGKSAYFSLKMFSSYLNIVQTPQEIVEIYERLRGLKGENVNISYNSMLLGKSGIEYAALVVITKEKDRYVVGHVLSKNKLDMVVDLMQYIIMMLDTNSKIILIVSDESISKIIPEKLENDIKIIPLEPKENLIERIRNSIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2F3</accession>
    <name>I0A2F3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1172</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1172"/>
    <dbReference type="EnsemblBacteria" id="AFH43160">
        <property type="protein sequence ID" value="AFH43160"/>
        <property type="gene ID" value="FFONT_1172"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1172"/>
    <dbReference type="HOGENOM" id="CLU_1399693_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="194" mass="21663" checksum="690D4E59D480B363" modified="2012-06-13" version="1">MACLSEDDRSRKIFYILGISGLLAVIFLIGAIVYAEIDTPSLKPMYSQPGLKLDYLMNVSFGNFSVQYVRIETVVSRYPPYNYTVNVIVANTTQFPPPPRTIEYNNNVTFPMGNGYAMEGLQLNSLVPIGTVDYELNGVKILGERFLDPQTGSIITVDLDKGIILEVRYSYYGVLNDIKLIDMSGGSLSYAWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2G6</accession>
    <name>I0A2G6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable thymidylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tmk</name>
        <name evidence="4" type="ordered locus">FFONT_1185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1185"/>
    <dbReference type="EnsemblBacteria" id="AFH43173">
        <property type="protein sequence ID" value="AFH43173"/>
        <property type="gene ID" value="FFONT_1185"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1185"/>
    <dbReference type="eggNOG" id="arCOG01891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_0_2_2"/>
    <dbReference type="OMA" id="QMAYLFA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="3">
        <location>
            <begin position="55"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="57"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="242" mass="27826" checksum="C9A3C486B7D98933" modified="2012-06-13" version="1">MIDKYSSEDAIILRPGTKIFLKRILSYNLDMSKILEEPKFSFLKSDEKKGRYVAIEGIDGSGKTTIAEKVCNLLMQGGKRCILVREPWTLEIKKLLENNPKIDPVVEAFLFATDRMILNYNVISNALKEDTYVISDRCYLSSLVYQYIRGAEESIIFALNSLIIKPDAIFLLDVSVETGLKRLMEKKKRELTHLEGFEFLKKVKERYLEISNTLKDQKIFKIDGEAKPEEISEAIFNKIIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2H7</accession>
    <name>I0A2H7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">8-oxoguanine DNA glycosylase/AP lyase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">8-oxoguanine DNA glycosylase</fullName>
                <shortName evidence="4">8-oxoG DNA glycosylase</shortName>
                <ecNumber evidence="4">3.2.2.-</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">DNA-(apurinic or apyrimidinic site) lyase</fullName>
                <shortName evidence="4">AP lyase</shortName>
                <ecNumber evidence="4">4.2.99.18</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4" type="primary">ogg</name>
        <name evidence="6" type="ordered locus">FFONT_1196</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the type-2 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="4"/>
    <dbReference type="EC" id="4.2.99.18" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1196"/>
    <dbReference type="EnsemblBacteria" id="AFH43184">
        <property type="protein sequence ID" value="AFH43184"/>
        <property type="gene ID" value="FFONT_1196"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1196"/>
    <dbReference type="eggNOG" id="arCOG04357">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104937_0_0_2"/>
    <dbReference type="OMA" id="FCILTAN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00241">
        <property type="entry name" value="Ogg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012092">
        <property type="entry name" value="DNA_glyclase/AP_lyase_Ogg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005954">
        <property type="entry name" value="Thrmst_ogg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="5">
        <location>
            <begin position="48"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="site" description="Important for guanine/8-oxoguanine distinction" evidence="4">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="212" mass="25175" checksum="9C21809F379A9949" modified="2012-06-13" version="1">MELVEKVIELKKDEKLRELINGRIIEFRKLKEEGSCEDIFSELSFCILTANFSAERGIFIQKEIGIGFLYLSEEALARRLRELGHRYPEKRAEYIVKARKFKDKICELVKNSDEDRSKQIRKWMADNIYGIGYKESSHFLRNTGFFNLAIIDFHILDILKKYKLLKQEFKTLTRKRYEEIEKVLEKIATTSILSLGELDLYLWYMETGKVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2K3</accession>
    <name>I0A2K3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N2,N2-dimethylguanosine tRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_1222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1222"/>
    <dbReference type="EnsemblBacteria" id="AFH43210">
        <property type="protein sequence ID" value="AFH43210"/>
        <property type="gene ID" value="FFONT_1222"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1222"/>
    <dbReference type="eggNOG" id="arCOG01219">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010862_5_1_2"/>
    <dbReference type="OMA" id="VFYNPVM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004809">
        <property type="term" value="F:tRNA (guanine-N2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="PTHR10631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 7" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH43210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="389" mass="44645" checksum="26CC7149850B0943" modified="2012-06-13" version="1">MDSVLENIELKEGRAKFFLPMSNEFFRSDGKLEPAWLPIFYNPYSSINRDLTVLGIKAFSSLFRKIENFIEPLAGSCVRTIRVVLENDDIEINGYANDISKDAVEYCVKNISLNGLEEKIKVMNEEANFFLHFLLKKGIKQDAVDIDPYGSPINFLDSASKAISNNGLLFVTATDIGTLMGKYKDTSLRRYGSHVYKTDYGREIAARVLIYSVIRAFSSNEKNAYPLFTYYHEHFLKTGFLIKKEKQANKIGFLCIDSNSGYPFDKVILGKDGFKSECSNYIGPIWLGELWNRDFLLKVEDFYRKGKENYSIKLEKDINTMLAESEIENPFYYHIDKIASKLKKNVPKFEKIEEELKKLGYASSRTHFDAKGIKTNAPYDIVFNVIKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2M8</accession>
    <name>I0A2M8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1247"/>
    <dbReference type="EnsemblBacteria" id="AFH43235">
        <property type="protein sequence ID" value="AFH43235"/>
        <property type="gene ID" value="FFONT_1247"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1247"/>
    <dbReference type="eggNOG" id="arCOG01644">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105758_1_1_2"/>
    <dbReference type="OMA" id="LEIVAFF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010397">
        <property type="entry name" value="DUF996"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06195">
        <property type="entry name" value="DUF996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="209" mass="23485" checksum="39082E380ECAB8F5" modified="2012-06-13" version="1">MLKIIFGIFIIFSFYNLDMVTFMTRLNDARLIGGIGSLFYLASFFTGFHFTGSILLLIGLVLIGVAVKYISDETKDSTIFNNFMYFILITIIGSIVAIILGLGTFLLGAITIRRMFFSAILTFIVALIIVWVTFTIASTYLRRSFEQIKEKTNVNLFSTAGKFYFWGALLTIILVGFIILLIGIIFMVVAFFSLPDKLPEQAQTPTQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2P1</accession>
    <name>I0A2P1_FERFK</name>
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        <recommendedName>
            <fullName evidence="3">Translation initiation factor 6</fullName>
            <shortName evidence="3">aIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">eif6</name>
        <name evidence="4" type="ordered locus">FFONT_1260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eIF-6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1260"/>
    <dbReference type="EnsemblBacteria" id="AFH43248">
        <property type="protein sequence ID" value="AFH43248"/>
        <property type="gene ID" value="FFONT_1260"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1260"/>
    <dbReference type="eggNOG" id="arCOG04176">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071894_1_0_2"/>
    <dbReference type="OMA" id="GEDTTGP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="PTHR10784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="228" mass="24695" checksum="B9B1EBB71D6D7F52" modified="2012-06-13" version="1">MQKMNFSKLSVFRNHNIGVYIFSNNKFALVPNGISHGSKKVVEETLGVDAIETTIMDTRIIGVLVSGNDRAILLPYAVKSEEIDRLKESIGGSVKIGIIDSKFTALGNYITANNKFAYISPLLEDEIARKISDLLDVKVSKKSYLGISIIGSIIVSNDYVAFVHPMLSDSDASEIKNDMKVEVVQTTVNEGVPFVKSGIVANNNGVLVGSATTGTEILNITSLLNQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2R1</accession>
    <name>I0A2R1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type Mn2+/Zn2+ transport system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_1280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1280"/>
    <dbReference type="EnsemblBacteria" id="AFH43268">
        <property type="protein sequence ID" value="AFH43268"/>
        <property type="gene ID" value="FFONT_1280"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1280"/>
    <dbReference type="eggNOG" id="arCOG01006">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094088_0_0_2"/>
    <dbReference type="OMA" id="RIDLMAY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH43268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="294" mass="31934" checksum="4C734BE237ACF080" modified="2012-06-13" version="1">MKIEDIYLSMLGLSIPLAIILSISYPSYFNPIWMTVLLGSALIYGIIGPILSAKNLLFLAGSIPHSALLSASMGILLSMMISGSNLVWSIIFNVILIFTIGLVIHRGGDPNKYTSIFIGTTASLTVIVLYYITNHFYLLTSVESILLGDPLLSTRSDAILIFVLTAITLLFFGLTYKEHIYIGITGEEAKLAGLRTEIYEFFFYLFLGITSATLMKIVGFILTHVFILIPGAAGSLVARKSKEAIALSMNIAAYSAIIGLFLGVFFNLSPSGTTGICMIAIYIVINVAKKVYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2R2</accession>
    <name>I0A2R2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator, CopG family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1281"/>
    <dbReference type="EnsemblBacteria" id="AFH43269">
        <property type="protein sequence ID" value="AFH43269"/>
        <property type="gene ID" value="FFONT_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1281"/>
    <dbReference type="eggNOG" id="arCOG01008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113319_3_0_2"/>
    <dbReference type="OMA" id="VAYTHLH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038733">
        <property type="entry name" value="Predicted_DNA_bind_prot_RHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12651">
        <property type="entry name" value="RHH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_3" evidence="2">
        <location>
            <begin position="8"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="NikR_C" evidence="1">
        <location>
            <begin position="60"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
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</entry>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1316"/>
    <dbReference type="EnsemblBacteria" id="AFH43304">
        <property type="protein sequence ID" value="AFH43304"/>
        <property type="gene ID" value="FFONT_1316"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="311" mass="35780" checksum="E362D6FA8B002504" modified="2012-06-13" version="1">MSPTVLSFWGKGGVGKTTLTFSLSLELALRGKKTIYLTTDPTPPLPYWGSKDCDWREYKAKCGDNLELYLMSEKIVRELWIKKFGEEVYEVASSIFPVEREVIDYVAGAPGIADEFLMYFVQNLCRNESADYIVWDTTAAGGSIRLIRLEKEFYEHLGQASKMYLKIKGTLEKIRRGKKDPAELIDSWRKIAEEVLSFLSSSSHKAYIVSIPDYYGLQVTSSIYEELTMNKINVEKVILNMVFGEEVQKECKEIGNMAREQKKYIQEFFKKFEGKADICMVNYYFEELQKESHILEEIGKRIIESCIGGLQ</sequence>
</entry>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="term" value="F:oxidoreductase activity"/>
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        <property type="project" value="UniProt"/>
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        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="60"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43307.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="100" mass="11568" checksum="8358DEE3FA763B15" modified="2012-06-13" version="1">MSTSQIKKEKKTLDEIMKEDKWEVDEKPHIVVDYEQCEKCQSKPCLYLCPAGCYTLSESGKIMFNHEGCLECGTCRVICPLKAIKWEYPEPGKGIHYRYG</sequence>
</entry>
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    <accession>I0A2V9</accession>
    <name>I0A2V9_FERFK</name>
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        <submittedName>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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    <comment type="similarity">
        <text evidence="2">Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.</text>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
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            <end position="31"/>
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            <end position="80"/>
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            <end position="111"/>
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            <dbReference type="SAM" id="Phobius"/>
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    <evidence type="ECO:0000313" key="8">
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="347" mass="38289" checksum="52BA5A6573D121F4" modified="2012-06-13" version="1">MAIFKHRKQLVFFSLLLLVFLSVPLCIYLGYYKASIFEITRVIFRPDNSQLSIVVWDLRIKRILAAIIIGAILGGSGTAVQASMRNPLASPFTLGLSYAASVGVAVGLLALNEGSILRYQINIQNPFIIAFFAFIFSLIQVLIILLLAYKAGLSSISLVLSSIAISFAYQALLYLIQYFFLNEIYVSTVVFWTFGDLERISWEELKLIAIVSLLIVIPYFVYRSIDYDVIIGGDDIAKSSGINPRRLRFETIFIAALGASLATSFVGVVGFVCLLAPHISRFLVGGGHRYLMPTSMAMGSLILLWSDTLGRIIISPVTIPVGIMTSLLGVPLLIFLLIKGEKHGYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2X0</accession>
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        <name evidence="2" type="primary">rrp42</name>
        <name evidence="5" type="ordered locus">FFONT_1339</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family. Rrp42 subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH43327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1339"/>
    <dbReference type="EnsemblBacteria" id="AFH43327">
        <property type="protein sequence ID" value="AFH43327"/>
        <property type="gene ID" value="FFONT_1339"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1339"/>
    <dbReference type="eggNOG" id="arCOG01574">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038194_0_0_2"/>
    <dbReference type="OMA" id="PESVFEM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="RNase_PH_archRRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00622">
        <property type="entry name" value="Exosome_Rrp42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020869">
        <property type="entry name" value="Rrp42_archaea"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="3">
        <location>
            <begin position="36"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="4">
        <location>
            <begin position="198"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="274" mass="30054" checksum="183FFBE3B32A1DD2" modified="2012-06-13" version="1">MSVTPTSYPLIPKMKRETIISVLETGKRIDGRALDEVRKITIVPNYIEKSDGSALVYLGDTLVLVGVKVEPGAPYPDNPNEGVLMVNAEFVPLASPAFEPGPPDENAYELARIIDRSYRESKAIGLGELALVPGQKVLVVWNDIYVLNHSGNLIDASAIASLVALMNTRIPVYEEADGGNFVKKENEYKGNLNVKKKIITATIAKIGNYYLADPTDEEEYVSDARLSVSFTEDGIIAGMQKMGIGYLDENDINQMIDLAWKTAKIYLGEISKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A301</accession>
    <name>I0A301_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MCM family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the MCM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1370"/>
    <dbReference type="EnsemblBacteria" id="AFH43358">
        <property type="protein sequence ID" value="AFH43358"/>
        <property type="gene ID" value="FFONT_1370"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1370"/>
    <dbReference type="eggNOG" id="arCOG00439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000995_6_0_2"/>
    <dbReference type="OMA" id="NAYTCDR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="MCM"/>
    </dbReference>
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        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="PTHR11630"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM" evidence="4">
        <location>
            <begin position="296"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="696" mass="79010" checksum="CC4A7CF9373BE57E" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A318</accession>
    <name>I0A318_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1387"/>
    <dbReference type="EnsemblBacteria" id="AFH43375">
        <property type="protein sequence ID" value="AFH43375"/>
        <property type="gene ID" value="FFONT_1387"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1387"/>
    <dbReference type="HOGENOM" id="CLU_2565561_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="81" mass="8957" checksum="AFEADE4B0E23C67B" modified="2012-06-13" version="1">MPPPVEAPAVLGAPFDPPPNIEHELSHSTRGFLDEPTIRYQLVFKVSAFLFSLSKVSDIIESRTLEESSSGFEKSLKNLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I0A321</accession>
    <name>I0A321_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1390"/>
    <dbReference type="EnsemblBacteria" id="AFH43378">
        <property type="protein sequence ID" value="AFH43378"/>
        <property type="gene ID" value="FFONT_1390"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1390"/>
    <dbReference type="eggNOG" id="arCOG05661">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2327157_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="98" mass="11037" checksum="13D4EF304ECA6763" modified="2012-06-13" version="1">MLADFLGIVGMLLISFAWVTTIKNIPPRSLSGIYSAGSFFLFLYALFSREVLFAMVNLFAVSVSLYQFLASFKKEEYSQHKKESSQESALELKSSPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ59</accession>
    <name>H9ZZ59_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0020</name>
        <name evidence="2" type="ordered locus">FFONT_1394</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
            <strain evidence="1">Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0020"/>
    <dbReference type="EnsemblBacteria" id="AFH42016">
        <property type="protein sequence ID" value="AFH42016"/>
        <property type="gene ID" value="FFONT_0020"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH43382">
        <property type="protein sequence ID" value="AFH43382"/>
        <property type="gene ID" value="FFONT_1394"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0020"/>
    <dbReference type="KEGG" id="ffo:FFONT_1394"/>
    <dbReference type="HOGENOM" id="CLU_2985511_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="57" mass="6808" checksum="88BADAFE1C2B043A" modified="2012-06-13" version="1">MKFRIVGNKADFKLKDKLNIFLLYIFYYNFLEKMGKNISDLAIFAIGPKSFYYNTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ73</accession>
    <name>H9ZZ73_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (cytosine(72)-C(5))-methyltransferase</fullName>
            <shortName evidence="4">tRNA:m(5)C72 MTase</shortName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0034</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>cytidine(72) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(72) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:61988"/>
            <dbReference type="Rhea" id="RHEA-COMP:15996"/>
            <dbReference type="Rhea" id="RHEA-COMP:15997"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0034"/>
    <dbReference type="EnsemblBacteria" id="AFH42030">
        <property type="protein sequence ID" value="AFH42030"/>
        <property type="gene ID" value="FFONT_0034"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0034"/>
    <dbReference type="eggNOG" id="arCOG00973">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00986">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_1_0_2"/>
    <dbReference type="OMA" id="YQGAMLY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02237">
        <property type="entry name" value="NSUN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043699">
        <property type="entry name" value="NSUN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="5">
        <location>
            <begin position="131"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="354"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="414" mass="46619" checksum="53D46752BC3D92B6" modified="2012-06-13" version="1">MYLKRHSDILVQRGRSFLSGGAVEVRCKGGFLRSIKAGEELVEKIEEISSSYMIRAEDVICSLAEPVENYYLRVNIMKGSREYVLSKMPHDSHASQDERFEEMINVKVRGGEKVEEMKRYVIADIKAAERVMLGSDLFMPGALKVVNGKRGEEVAVVSENGYVVGSGILDIDPSEVNPKKRGIAVRIERSPYKMVKLNSLDIFKEGYIYDQSFPSMLLIHASSPREGDVIADLTASPGGKISHAYEFTRGKAEYYAFDHTNAKVEKVEETMRRLGHENVKVYKADSRSLGKEFPWLSPSFTIVDPPCTGLGNRPRLSFSFEEEEQEVLIRLQKALLSEAIRITSPGGKIVYSTCTLTVEENEGVVEWALKNFPVCAEEPLAPYPRTKLSDFPFARFLPGYHKYPGFFFAVLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZA1</accession>
    <name>H9ZZA1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        </source>
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    <sequence length="163" mass="17339" checksum="FD6135E296B870BA" modified="2012-06-13" version="1">MSQEGEGIPEEKGERRSRKGKERGISEIVSVMALLLIAVVAVFALRGWLSTQQSRMTNIDMATASYSVQTTFSGYVISLDVRNNLQGNLAVNQVQVILSNGTALSFSATGITPALPNTISAKSDQIYVITVNAGSGVAVKQINVRVQEPISLQSQWITAIGGG</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="619" mass="69497" checksum="C407E3E35B999DC7" modified="2012-06-13" version="1"> </sequence>
</entry>
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    <accession>H9ZZE5</accession>
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        <submittedName>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="81"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="140" mass="15717" checksum="C78E94D923825B67" modified="2012-06-13" version="1">MSKKFGNFTIESIMSSPPVVVHKETSVHEAARIMFNNRIGSVLVVEDDGRLIGILTERDLVYLVASDKLHTASEMKVWHLMTENPITVKANETIGDALSKMKEVNIRHLPVVNDEGKPIGIVSMRDILDYIISFLDLSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZI3</accession>
    <name>H9ZZI3_FERFK</name>
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        <lineage>
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    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <reaction evidence="1 8">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="8"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH42140">
        <property type="protein sequence ID" value="AFH42140"/>
        <property type="gene ID" value="FFONT_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0148"/>
    <dbReference type="eggNOG" id="arCOG00487">
        <property type="taxonomic scope" value="Archaea"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
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    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="537"/>
            <end position="653"/>
        </location>
    </feature>
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            <end position="146"/>
        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00836"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42140.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="653" mass="75222" checksum="39384ADE2B0F5815" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZI4</accession>
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        <submittedName>
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        </submittedName>
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            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFH42141"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="51"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="221" mass="25355" checksum="4D26B21D65DA5468" modified="2012-06-13" version="1">MIKLNNKGKRITFKIFDERTKEYDSWFDKQQKIYKSEVDLAKRFPCISPCLEIGVGTGRFAKPLNVEFGIDPSVSSLKISAEKGIEVIRATAEYLPLRDESFNTAYLIVTLCFVEDPNRTLLEAFRILKPEGKLVTCVVPLDSQWGSFYEEKKKKEETFFYKEAVFFTKKEIKEMISNAGFILEKFGSVLHYPPNSSPVPEEPSFNENGSFVCYEAKKPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZJ8</accession>
    <name>H9ZZJ8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="352" mass="39786" checksum="BB98E87648AA0325" modified="2012-06-13" version="1">MDDSTLTALLEKKFSGEALSESVVIGESIGGLYRPSKQSVYFHKVKNNSKATLSLLEIGAIFDKQESVKWRIWFDGISVSKQFKPNFILPIGENTYGATVIDITPLVNREAKRRFHKLTVISSTPVFLTHATIIKLIEDNSDTTNWIKYYTGGAIIKSQEIKKISVKSNELRQNNIHFNIFAQKVPQYLEIRVNERYVKRLEISKNCDDYQIPFDKEPIFTLSFKNDGIDVGGKSKSFILITNLIVNSASKKQRSIDLEAEIRGRNESGVIVNVDVFNNSESPLEAPMLVAFSSGILVSKIDLESIQPKSSAKRELVLKLPPNSSSITLRLIWKENSEPQYIEKKIKITNQI</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="AFH42188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="83" mass="9359" checksum="125026D20DEFD0E2" modified="2012-06-13" version="1">MVKVRLFAMLYELTNKKELEVENANTVREIIEKLDSMYPGFKGFLEKGYLILVNGINIVHLNDLDTKVNDTDVVSIFPKVGGG</sequence>
</entry>
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    <accession>H9ZZQ3</accession>
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42210">
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        <location>
            <begin position="20"/>
            <end position="39"/>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="EMBL" id="AFH42210.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="499" mass="54764" checksum="F08C7CB446402508" modified="2012-06-13" version="1">MIVEILWKKIVKKMNKFKTLAILIVPLVGLIAIASVFVYDPVQINVKPTNPSIKFQAPPPSYPMSLQRTSRSAICYTDFEQMPSGWSNIGGNWSISPNEGYKGNALYGKDNDGGIGYASQYYWQTSISNYNSLWVSVKVKLATTNPDVYKGIALIDSNKSQLYEISIYNGELYIWGYSNRWGWNQFNYFSISNYNVNNWYILVVNYVYASSSISISAYVYDTSGALVASTSATIKGRYLFQPSYVGLEIDDVTNNLSGSGVYFDDFITSTTDPRYVNFLNVPQGYKIEVWDNLGNLINSTISTGNNVQLYILSDIVVGTGSGGSIIIGSNAGKYTLNYTVPSTDSILGGDTYTLTSGVLSFSFGANKTSINVSAAISGNTYNITGFILLSIINTDSSSYYVILFLNNMTGNMGSLNANIALYNSTYTSSNYIQISNGAILSNSTGWVSIPPNGYVNATFSGFFTQSSQQATLYLQLEYCTMPNNQGACVFYPVQITVNS</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42223.1"/>
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            <begin position="6"/>
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            <dbReference type="SAM" id="Phobius"/>
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        <source>
            <dbReference type="EMBL" id="AFH42223.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    <sequence length="104" mass="12049" checksum="DC68CC6FF724B1AC" modified="2012-06-13" version="1">MEKEKGNIWYIFAYILTWLSGIIVFITEGQKDKRLKFHSLQSIFLGILGTIIDLVFFFIPFLGPFLLFLVWLYGMYIAFKAYSGVDVKVPVLGDYAAKYSEYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZT0</accession>
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    <organism evidence="2 3">
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0246"/>
    <dbReference type="EnsemblBacteria" id="AFH42237">
        <property type="protein sequence ID" value="AFH42237"/>
        <property type="gene ID" value="FFONT_0246"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0246"/>
    <dbReference type="eggNOG" id="arCOG01940">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_0_0_2"/>
    <dbReference type="OMA" id="AVWKHIE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="79"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="322" mass="36395" checksum="583BBB937C1CBD4E" modified="2012-06-13" version="1">MNEKALNYEVSIFKYLAEKGEASIDELSDVFSLPPSNIIEKIKKLNEIGLFINSEDNKFKIPSSSDFSLIALYLKRMNTFINYNMIFYEECDGSQEIAEEIAKNGAEEGNLVLCEEIKNARGRFGRKWHAPKGGIWFSLILRPPSLEWINLISLAMGASVSIAIEDVLNIKSGLKWPNDVLINEKKICGILSEAKITDDRLDYVIVGVGLNANNELPNELKAQAISLKQIYGRNIPALPLLGRILYLFGWEYKKIIEGRVEAIISDWKLRSLTIGRKVRIENRDEIVYGTAVDIDTDGSLVVNLENGKIEKFYAGDVFHLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZT6</accession>
    <name>H9ZZT6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polyprenyl synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0252"/>
    <dbReference type="EnsemblBacteria" id="AFH42243">
        <property type="protein sequence ID" value="AFH42243"/>
        <property type="gene ID" value="FFONT_0252"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0252"/>
    <dbReference type="eggNOG" id="arCOG01727">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_5_0_2"/>
    <dbReference type="OMA" id="WLIAESI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="290" mass="33110" checksum="A67B7256E3F929B0" modified="2012-06-13" version="1">MEAFFEDKKTLLDKKISELLEEHVEANAIDVSKYIVEGGKRLRGLLTLFITDVLVNDYNRAVRAAVALELVHSCSLAIDDIIDQDVKRRGRPSVWVAKGISKTVLVSNLLIPIAIKEVSYLGTSAVKKVIETWLKVTMGEIYDVFDESSSYLKTIEYKTSSLFQLSLDLAVIASNREDLINVFERYGLYLGYLYQISDDLVDAKKYIENKNEEKPLFLIKMLNWLGASNLISWEELKLMVFKKLNEFYNSAITAINGINDKDLTLILKELPIYIVDKILEEGNLKWNLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZU2</accession>
    <name>H9ZZU2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0258"/>
    <dbReference type="EnsemblBacteria" id="AFH42249">
        <property type="protein sequence ID" value="AFH42249"/>
        <property type="gene ID" value="FFONT_0258"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0258"/>
    <dbReference type="eggNOG" id="arCOG01622">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_10_0_2"/>
    <dbReference type="OMA" id="GWHHARV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="149"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="318" mass="36198" checksum="5EFFCBDB7FED08F1" modified="2012-06-13" version="1">MIPLEKGIGIIGAGYMGQAHIRVLSEIAKKYSLKITFVVEPDINKGMDISAKYQLRYYQTLSEAIKNEENFIAFVSSPTSTHLDYIDELLSNGIEYIFVEKPLGSDINRAKEIFKKYGRNVLEKVMVGHIERFNPAFVEFKKIVKEESVLGDPISITSRRVGPFAGRIRDTGVILDLAIHDIDLSLSLFDNEPKGIDSYKYNVYSKEYEDSCFIILNYGKFLHFIEANRVTPYKERKAIFTGTKGIGIIDYMQQSLEVFTGLWKMERSVNKREPLAVEDEAFLNAVIKKEKVPVTFEDGIRSLEIALKALEIAKNNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZW9</accession>
    <name>H9ZZW9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0286"/>
    <dbReference type="EnsemblBacteria" id="AFH42276">
        <property type="protein sequence ID" value="AFH42276"/>
        <property type="gene ID" value="FFONT_0286"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0286"/>
    <dbReference type="eggNOG" id="arCOG00193">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="YSLFPWR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        <source>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    <feature type="domain" description="MFS" evidence="2">
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        <source>
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        </source>
    </evidence>
    <sequence length="369" mass="41389" checksum="C3215200D456DEE5" modified="2012-06-13" version="1">MYALGSYYYSRISGKLKQDQFAIFSLILMASSILFMAFSPSAIFIILFNGVFGMSIAFISPLMAGMIINYLMKDNIGITRTNVISSLGIIFGYIFAAFGGALFSSKDLMFINTAFTLAVLPLVKYFPEKFKTKGERRALILSLMPQVAGRIRAIPHEIVKYERELSFKALYNDFKKMFYFKKLREMPTVLLGATVLYTAIQIFFTPMPSYLKIFGYTDSDIYTLYLINNFTTLLLYDFMRKRTETESGTWKLLIIAVMVRPILFLFPLLTYLKVPINLIFVIFYIGIGISWSGISVALPVLIMKNADPESKGLALSKMNATTTIGTIVGSFVGGIVSKYYFITGTSILASLMALVSLAIFFKASKIIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A071</accession>
    <name>I0A071_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="2">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0388"/>
    <dbReference type="EnsemblBacteria" id="AFH42378">
        <property type="protein sequence ID" value="AFH42378"/>
        <property type="gene ID" value="FFONT_0388"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0388"/>
    <dbReference type="eggNOG" id="arCOG01307">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_21_2_2"/>
    <dbReference type="OMA" id="ATIMSKW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00745">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="SSF116846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIT" evidence="7">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="136"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="376" mass="42765" checksum="570FD1714D6C07FD" modified="2012-06-13" version="1">MAFPYLQEMATRYARAAVAADKDGDYETAINNYRKAIEILTKIVRMYPDSPLISTYLEMIKSYEKRIQQLQSNTEAIESNTASKSNEKDSFINDIVLTQKPNVKFSDIADLKEAKQAIVEAIVYPVKRPDLFPLGWPRGILLFGPPGCGKTMLAAAVANEVNGYFLYVDAASIMSKWLGEAEKNVSKIFKYARQKSEEGSPAIIFIDEIDALLGTFSGEVGGEVRVRNQFLKEMDGIQDKDKKIHVYVIGATNKPWQLDEAFVRRFNKRILIPLPDLESRRQLFALYTKGLNLSSDVDLDRLAQLTEGYSASDIRDIIQATHTLVIREFFEQKNGEGEPRSITMEDFLNILKERKPSVDPLFVKRYDAWFEKFKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A081</accession>
    <name>I0A081_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Xylose isomerase domain protein TIM barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0398"/>
    <dbReference type="EnsemblBacteria" id="AFH42388">
        <property type="protein sequence ID" value="AFH42388"/>
        <property type="gene ID" value="FFONT_0398"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0398"/>
    <dbReference type="eggNOG" id="arCOG01895">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_992474_0_0_2"/>
    <dbReference type="OMA" id="DGKTHEH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="280" mass="33122" checksum="4BE48A00FB3CB6E0" modified="2012-06-13" version="1">MIFYAFPVWHQKPLRKEEFEAIYSSGFSYAEISIEYPWPFWKSESFYEQIEFIKSSGLKIGVHLPWRDILIISPYDEIREGAANYLKKLVQTLEKINAEYAVMHLTTREEINLKDETYLQNIETVLNQLISEYKMHGIELLFENPPAGILSNRYNFTSLINRLNARICFDAGHLISRFLKGNSSNLQNVINFTNDWLFNLFEYIKVVHIHGATKVNGEVIEHYLIDDYVDFFYNILEKFNQNKKDVIVTLEIFYKNLERKNADLTTLTNSLNLLKRKFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A086</accession>
    <name>I0A086_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hexulose-6-phosphate synthase (D-arabino 3-hexulose-6-phosphate formaldehyde lyase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0403"/>
    <dbReference type="EnsemblBacteria" id="AFH42393">
        <property type="protein sequence ID" value="AFH42393"/>
        <property type="gene ID" value="FFONT_0403"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0403"/>
    <dbReference type="eggNOG" id="arCOG00053">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081825_1_0_2"/>
    <dbReference type="OMA" id="WEQAQEW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04726">
        <property type="entry name" value="KGPDC_HPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041710">
        <property type="entry name" value="HPS/KGPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OMPdecase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="224" mass="24494" checksum="B7BF462177BE8A0C" modified="2012-06-13" version="1">MKFNTLKEPPYLQVAIDVTDLKKALFIVRQVIDLSDKIIIEVGTPLIKSYGMLPVEIISYLYPEKIILADMKTMDVGYLEANLAFKSGATISTVLGAADNETIQGALKASLEYNKFIQVDLINVKDLASRAREVAELGVHIVGLHAGIDQQTNKKLRAIDMIELLKEIKNAVEKTSLVSIAGGIKQGELKRFAENGADIIVVGGAITSSEDPREVAKNMLKEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A096</accession>
    <name>I0A096_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Purine or other phosphorylase, family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0413"/>
    <dbReference type="EnsemblBacteria" id="AFH42403">
        <property type="protein sequence ID" value="AFH42403"/>
        <property type="gene ID" value="FFONT_0413"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0413"/>
    <dbReference type="eggNOG" id="arCOG01324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_1_2"/>
    <dbReference type="OMA" id="PQCLLCG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="4">
        <location>
            <begin position="15"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="239" mass="26148" checksum="2F015538F50299AD" modified="2012-06-13" version="1">MPIHLKIGKNDLAKKVVTVGDPNRASLLANSLLDYPKLINENRGLLSYTGTYKGERISIVTHGIGMPSALIVFEELVSLGAKAIIRFGTSGSLKEQVKIGDIVIAESAGHFNSSAIRQYFDDIIPPNGFSFDLINTLVDNFKRSDFNFHVGPIISSDAFYSESKDLALKLSRLGFFAIEMECAGLAMIGWLRGLKTGCVLYVTNHLLRNGEEMLDSAQINKKMVSVATNIFDALTNFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0B5</accession>
    <name>I0A0B5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="2">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pcn</name>
        <name evidence="4" type="ordered locus">FFONT_0432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0432"/>
    <dbReference type="EnsemblBacteria" id="AFH42422">
        <property type="protein sequence ID" value="AFH42422"/>
        <property type="gene ID" value="FFONT_0432"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0432"/>
    <dbReference type="eggNOG" id="arCOG00488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_1_0_2"/>
    <dbReference type="OMA" id="NASKMKY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="249" mass="27574" checksum="8D1E000F79D733B9" modified="2012-06-13" version="1">MKIILNDASDLKDIIDVLAKVAEEVPLTISEKGISSKTLSEDKTTMSILEIPSEIFNEFELEENISFRVKIRDFNKILKRATKNDVLELSLEKDKGILKIVFKNSKNGAIRSFDLQVSIENVEDIGEPKVDLPIEFEILAGDLKDILDDVSKVGEEVEFEYKNSSIVIKSEGQGRAYIATLTEGNPLILLKSSVSEASSKYGVELLSSVAKKMDSNTTTKVAFGSQLPIKIQVQFTPGGSLTYWVAPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0C2</accession>
    <name>I0A0C2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0439"/>
    <dbReference type="EnsemblBacteria" id="AFH42429">
        <property type="protein sequence ID" value="AFH42429"/>
        <property type="gene ID" value="FFONT_0439"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0439"/>
    <dbReference type="eggNOG" id="arCOG01355">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_3_3_2"/>
    <dbReference type="OMA" id="PESYNWS"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="204"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="463" mass="53452" checksum="6F10BDE55DBE6E2E" modified="2012-06-13" version="1">MDKGKIFQNEVNNIIKKRFDYHIALLYPSTYRSSLSSLGYQLIYFYLNSFEEIFAERVITESRGDYISIETGTPLSKFDIIFASAHYELEYPEIIRTLLRSRISPLKEERNRPILIIGGPSPTANPFPMGKVADFIFRGEFESTGKKFFDSIQYIDNPKKFKEMLSSIEGFWSLENRTEKISIVKDLDSSFFPIIQIQNPHTEPILGKGLMVETSRGCNRGCFFCMESAISLFRRERSENKIIELIEQGLEVNNLNRVIFFSLSFFDSALGEKILKYVVDRGIEASIPSVRIDSLDDNKIELIKKAGQKTLTVAPETGIYELRKSIGKPIKDEMILQIAEKLKALDMGIKLYYMIGLPGERQSDLDAIIAQVEYFWKTLRNKKKIKVSVNPFIPKPLTKMENEKMEEANELQRKIDYLNAKLSKISEFEYYPPKLARLQYTINSLGENAHVFLIEHALKKIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0D7</accession>
    <name>I0A0D7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Geranylgeranyl pyrophosphate synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0454"/>
    <dbReference type="EnsemblBacteria" id="AFH42444">
        <property type="protein sequence ID" value="AFH42444"/>
        <property type="gene ID" value="FFONT_0454"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0454"/>
    <dbReference type="eggNOG" id="arCOG01726">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_1_2"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="333" mass="37108" checksum="F875410226CBFDF8" modified="2012-06-13" version="1">MISLNDFLKSVSINIDSYIKEKLVGEPPDFYESSLYILKAGGKRLRPALVFASGYAFGGSEKYLLPFAAGVELLHNFTLIHDDIMDNDDYRRGVPTVHKLWGIPTAILAGDLLFSYSLYLPLHSCDDFEIKDRCIKASKKLAWASLTVAEGQALDMSFEKKESVSEEEYMNMIEKKTAALIESSAYIGATIGGADEKDLMHISEFGRKIGIAFQIVDDILGIFGKEEETGKPVYSDIREGKKTLLIIRALALSNKEERNKLISILGKKGLGKEEYAVAARIIEELGVLEYANIKARNLAEEAKSHLDEIKGSTNKEYISLLKDIADLVVRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0E9</accession>
    <name>I0A0E9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps4</name>
        <name evidence="7" type="ordered locus">FFONT_0466</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="4">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0466"/>
    <dbReference type="EnsemblBacteria" id="AFH42456">
        <property type="protein sequence ID" value="AFH42456"/>
        <property type="gene ID" value="FFONT_0466"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0466"/>
    <dbReference type="eggNOG" id="arCOG04239">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089738_1_1_2"/>
    <dbReference type="OMA" id="ARQFITH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_A">
        <property type="entry name" value="Ribosomal_S4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_S4/S9_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022802">
        <property type="entry name" value="Ribosomal_S4_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S4" evidence="6">
        <location>
            <begin position="5"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="103"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="168" mass="19568" checksum="CCE1A960B55C6C1C" modified="2012-06-13" version="1">MGDPRKLRKKWEGPGHPWDKTRLENELRLLGKFGLRNKKELWIAQTMARKIRHRARELLALPEDVRKKEEENLLKRLYSQGIVQSNAVLDDLLSINAEHILNRRLQTIVYQKGLAKTIYQARQMIVHGHIGINGRRVTSPGYLVKRSEEDLIDIISSSPFKRELEASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0F9</accession>
    <name>I0A0F9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0476"/>
    <dbReference type="EnsemblBacteria" id="AFH42466">
        <property type="protein sequence ID" value="AFH42466"/>
        <property type="gene ID" value="FFONT_0476"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0476"/>
    <dbReference type="eggNOG" id="arCOG08881">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1544144_0_0_2"/>
    <dbReference type="OMA" id="IESMGYY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="173" mass="19920" checksum="BFBCFAF3A5E12F24" modified="2012-06-13" version="1">MRKNRKSIAADYDLAERLKEFSKNRGMNFSKYLNEILEQCVYAEKQGLYPPNLLKEKRRQYVLEKLGFVLLPSDIIEKAKDVGELEKYGESIGKTISELSDESFEIVEMLVNNMKIGFSQSDSVMLIPSYGYQEFLRIFVVGIAKGAGLRVEKKGEFYLIYRNIDEAMKSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0H3</accession>
    <name>I0A0H3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0490"/>
    <dbReference type="EnsemblBacteria" id="AFH42480">
        <property type="protein sequence ID" value="AFH42480"/>
        <property type="gene ID" value="FFONT_0490"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0490"/>
    <dbReference type="eggNOG" id="arCOG00110">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_7_2_2"/>
    <dbReference type="OMA" id="HMIDVNE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="28"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="197" mass="22400" checksum="33E78FF47BF473DF" modified="2012-06-13" version="1">MSPHYFSKKQKYTYIDYMITYTLNNIQLKLYSSPSVFSSDEIDPGTDLLLKNLIIPEKGNVLDLGTGIGIIGIYLAKANPKLHVYMSDVNPIAIKLSKKNIKENNVEKNTVVVECNLYEKFKENFFVAIYTNPPISAGWETIEKIITDGIKYLQEKGVLQMVLSVGHERALEVGKKIYKSVEIIEKKKGYAIIIFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0H5</accession>
    <name>I0A0H5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">H/ACA RNA-protein complex component Cbf5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0492"/>
    <dbReference type="EnsemblBacteria" id="AFH42482">
        <property type="protein sequence ID" value="AFH42482"/>
        <property type="gene ID" value="FFONT_0492"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0492"/>
    <dbReference type="eggNOG" id="arCOG06042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174504_0_0_2"/>
    <dbReference type="OMA" id="HEVAFWI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
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        <property type="entry name" value="PTHR23127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DKCLD" evidence="2">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="108" mass="11883" checksum="989142659C0A9F36" modified="2012-06-13" version="1">MKTADVINEIENRISEFCGKSEWWNILAEEIVEIEGKASNPFERDINSLIERGIIVIDKPPGPTSHEVVAWVKRMLGVKKVGHGGTLEGLLDGDPGETPKSQVSCLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0K5</accession>
    <name>I0A0K5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl4</name>
        <name evidence="5" type="ordered locus">FFONT_0522</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="function">
        <text evidence="4">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0522"/>
    <dbReference type="EnsemblBacteria" id="AFH42512">
        <property type="protein sequence ID" value="AFH42512"/>
        <property type="gene ID" value="FFONT_0522"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0522"/>
    <dbReference type="eggNOG" id="arCOG04071">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026535_0_0_2"/>
    <dbReference type="OMA" id="WHQKVNV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_A">
        <property type="entry name" value="Ribosomal_L4_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_L4/L1e_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_L4_euk/arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019970">
        <property type="entry name" value="Ribosomall_L4-archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="PTHR19431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03672">
        <property type="entry name" value="rpl4p_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="272" mass="30084" checksum="09C6736A7D00846A" modified="2012-06-13" version="1">MVIVVNNSAKIEVDVFDKNAQPKEKTELPLVFYIPIRKDLIRRAFHAEFTAGLQPKGRDPMAGKRTPAESLGVGRGLARVPRVPGTSEGAFAPMTVGGRVAHPIKTEEKIVEEINKKERLLATASAVAATSSIEFVKKRGHKFTSTALPIVLDSSIEKEITKLSEAKELLKKLGVWEDVERSYSRIRIRSGKGKMRGRRYIEPKSLLFVLSSINTPFAKAVRNLPGVDVVSADNLSILHLAPGGVPGRLTIYTKDSLLKLQERFKNIRVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0K9</accession>
    <name>I0A0K9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
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                <person name="Bidzhieva S.Kh."/>
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    </evidence>
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    <sequence length="229" mass="24660" checksum="7B518A083C477E2E" modified="2012-06-13" version="1">MSTKKSVISKDAIVREGALILGSSIIGSRAFIDTGTVVGYPIRSRIKMLQEGKKGEIESEGATIGDNSVIRSNSIIYERVKIGKNVETGHRILIREDTEIGDNSIIGTDTVIDGRVKIGEFARIETGVYIPPYTIIGKNVFLGPRVVFTNDKYPVSKRLLGAIVEDNVAIGANATIIAGVRIGKGAVIASGAVVTKDVEPNTVVAGVPARKLMSKDEYNRKREKYESEA</sequence>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
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            <end position="25"/>
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            <begin position="102"/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
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            <dbReference type="ChEBI" id="CHEBI:57287"/>
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        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
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            <dbReference type="Pfam" id="PF17147"/>
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</entry>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <source>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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</entry>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
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</entry>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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</entry>
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                <person name="Ravin N.V."/>
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                <person name="Perevalova A.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="132" mass="14564" checksum="0E80AC64E1E3D141" modified="2012-06-13" version="1">MINPLTATGQAIGGLVMGMSRALFEEIIFDDTGGVANPNFSFYYIARAKDVPDDIRVKFLETPQANAPFGARGFSENVMIAVIPAIANAIQRATGVEITELPITNERVWKAIRQQRPDLIEKAMKALKEWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A116</accession>
    <name>I0A116_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0685"/>
    <dbReference type="EnsemblBacteria" id="AFH42673">
        <property type="protein sequence ID" value="AFH42673"/>
        <property type="gene ID" value="FFONT_0685"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0685"/>
    <dbReference type="eggNOG" id="arCOG01411">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017896_3_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="PTHR45919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="196"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="378" mass="43704" checksum="382D351A4BB7476B" modified="2012-06-13" version="1">MNILKICIFFSTLNTLGGGNVVLERMIEISKKRGDFVTLITNEPTNWEGLNRYYANGFPKPDRDLHALPVNVNIFGIYLRILQPLHPSMQKDCDLYINAHGDFMPFPVDVIYLHYPTFSMTSEQFMDVKYNKSLFWKAYFIPYQKIQEAIAGHFKNSGIILTNSKFSQDAIKRHLGKESFVIHPPVDVSDFIPASKNEEREDKVITCGRYSPEKNYEFVLRVASLLPEIKFEIIGSAKEKVSYQYYSKLVKMKEEMNLKNVSLLKDLPRKEQVERYSRAKVYFHAMRGEHFGIAPVEGMAAGLIPVVHKIGGPWTDIVDYGKYGFGYESLEDAKRAIEKAINNYEKMKDSVVERSQYFSSDRFDRKFSIVLEAFEKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A119</accession>
    <name>I0A119_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, ParA/MinD family, containing ferredoxin domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0688"/>
    <dbReference type="EnsemblBacteria" id="AFH42676">
        <property type="protein sequence ID" value="AFH42676"/>
        <property type="gene ID" value="FFONT_0688"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0688"/>
    <dbReference type="eggNOG" id="arCOG04073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067767_0_0_2"/>
    <dbReference type="OMA" id="DVEEPNC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="295" mass="32408" checksum="DC74BDDEA7E89442" modified="2012-06-13" version="1">MKGSIGVTGGKGGTGKSMVAVNIASLLARERELVLADLDVEAPNDHLLLNAKLENEEPVEIMLPFIDYKKCTGCGVCAKICDTGGIIMTREKMPMVLPRLCSGCRACYFACPEKAIVEGKRVEGYIYYTRVRLKDCEFTLVTGMLREGEEHTPPVVLPAKKKAISLSRDLLVIDTSAGTANHVSTALEGSKIALAVTEPTPLGLHDLELILKVLNELRIDAWVLVNRWGIGSSEKMYSIAEKIAKKHNAVIKAKIPYSRDLVEAYVRGIPIVEFYPDHEISKIFRSIAKEILDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A135</accession>
    <name>I0A135_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="1">dTTPase/UTPase</shortName>
            <ecNumber evidence="1">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="1">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0704"/>
    <dbReference type="EnsemblBacteria" id="AFH42692">
        <property type="protein sequence ID" value="AFH42692"/>
        <property type="gene ID" value="FFONT_0704"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0704"/>
    <dbReference type="eggNOG" id="arCOG05007">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_0_0_2"/>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="209" mass="22790" checksum="93389EFCF2A9632F" modified="2012-06-13" version="1">MGALKQLVLASTSKRRIEILREIGVDFLVIEPKYREIIIEKEPLRTVLNNAKNKGMSVLDASPSNSLILSADTVVVAEEGEILGKPDSLSTSISMLKKLNGRYHYVLTGICVIDKDSGSLECSHETTKVKFRKVSDEMIIQYASTLEGMDKAGSYAAQGLGALLIESIEGDFYNVIGLPIGLVYALLAKYGYDLFSNGIKSRIAAIKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A143</accession>
    <name>I0A143_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Proteasome subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">20S proteasome alpha subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Proteasome core protein PsmA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">psmA</name>
        <name evidence="5" type="ordered locus">FFONT_0712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="2">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0712"/>
    <dbReference type="EnsemblBacteria" id="AFH42700">
        <property type="protein sequence ID" value="AFH42700"/>
        <property type="gene ID" value="FFONT_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0712"/>
    <dbReference type="eggNOG" id="arCOG00971">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_4_1_2"/>
    <dbReference type="OMA" id="FQVEYAR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00289_A">
        <property type="entry name" value="Proteasome_A_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019982">
        <property type="entry name" value="Proteasome_asu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03633">
        <property type="entry name" value="arc_protsome_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PROTEASOME_ALPHA_1" evidence="4">
        <location>
            <begin position="10"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="239" mass="26372" checksum="378119746FC3CD81" modified="2012-06-13" version="1">MAFSPAMMGYDRALTVFSPDGRLYQVQYAFEAVKQGWSTVGIKTPGGVVLAAEKAVTKSLMDVVSIEKVSMIDTHIGVTFAGFGGDGRVLIEYARQIAVSHRLTYGEPIPIEYLTKQVSDLKQAYTQHGGVRPFGVSLLIGGIDSSGPQLFKTDPAGQYFGYFATSMGRGEAQIEEKLEKNYRKDMSLEEGILLALKVLKESSDQDLKAQNFDVGIILAEKKEFRKLTLPEIEDYLKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A162</accession>
    <name>I0A162_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0731"/>
    <dbReference type="EnsemblBacteria" id="AFH42719">
        <property type="protein sequence ID" value="AFH42719"/>
        <property type="gene ID" value="FFONT_0731"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0731"/>
    <dbReference type="HOGENOM" id="CLU_2930056_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="60" mass="7232" checksum="1D6ADD0FD84A24B3" modified="2012-06-13" version="1">MAEKGKEKEVWIEEKIKILDEKYKNASEEIDDLFQSTLNEFEHLLKSKGKEYSEKLKERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A172</accession>
    <name>I0A172_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0741"/>
    <dbReference type="EnsemblBacteria" id="AFH42729">
        <property type="protein sequence ID" value="AFH42729"/>
        <property type="gene ID" value="FFONT_0741"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0741"/>
    <dbReference type="eggNOG" id="arCOG04181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062565_0_0_2"/>
    <dbReference type="OMA" id="YGVPLYA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009995">
        <property type="entry name" value="DUF1512"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07431">
        <property type="entry name" value="DUF1512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016495">
        <property type="entry name" value="UCP016495"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="368" mass="40598" checksum="179D2B22787BFE96" modified="2012-06-13" version="1">MSSTITDWINAISQLAFLIVFLLLFLGFNQRFQIYISSRNIKLKLNILEKMALDSQNKTINFLKGLGLEKPEPVVERGINYFVIDPVNVEPTDIIKRMDILFKTREDRIEGLLEQVVPKASKVEKSIAVTALEIASALTLVFKYVRHYLITGQKTNNWILIMQLEMILPMLIKQAEAYSKALDVFLEGKPVGDGAGPLTVFKLAGPNAQPVEIVKDTVYFETIIENRKAYLIKASGPESNVGHPGFAVESLLNKLVNEEGKKVGMIITVDAALKLEGEPTGEVTEGAGAAIGDVGPEKIRIERAAANYGIPLHAIIVKMSMEEAILTMKKEIVDAIDKVTERIKELVKNIPEDSIIIIAGIGNSCGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I0A173</accession>
    <name>I0A173_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0742"/>
    <dbReference type="EnsemblBacteria" id="AFH42730">
        <property type="protein sequence ID" value="AFH42730"/>
        <property type="gene ID" value="FFONT_0742"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0742"/>
    <dbReference type="eggNOG" id="arCOG04234">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142655_0_0_2"/>
    <dbReference type="OMA" id="YVGYPII"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="154" mass="17828" checksum="46142ACE709D53AC" modified="2012-06-13" version="1">MKRLLLPPRIKVLEALSTIGDKRITIIDDKNAIVKSSDGTREYKVYLDLEKKIANSNDNGTFYKGYMGYPIVSFLMLKGIVPYKEDVAELLKGIQWKTLNEKYKSYKIVENIIKRSYKQKGRDPRELDQIMDSVMEALKNLELYTETENPQTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A181</accession>
    <name>I0A181_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Iron-sulfur cluster carrier protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ordered locus">FFONT_0750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42738">
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        <property type="gene ID" value="FFONT_0750"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0750"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="QGWVPVY"/>
    <dbReference type="Proteomes" id="UP000007391">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="PTHR23264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="279" mass="30634" checksum="13BAF998F9FF63AD" modified="2012-06-13" version="1">MSINAEFLKKEAEMKALSIRKTSMIRYKFIVLSGKGGVGKSIVTANLGLAFSKLGFKGKIGILDADIHGPSIPRYLGYENAEVLTDGEKLYPVETKYGIKLMSASFFLKDKELPIIWRGPLKIKLIRDMITSTEWGNLDLLLIDTPPGTGDEIQGIVEYISKITGAVVVTIPSDVSLHVVKRAVSFLKTVNVPLKGIIENMSFVRCNDGSVKRPFGEGGAKVEKELGEKIIARIPMNPLLSNPIDDTNNPYEYDNLNNNEVAISFMEAAKKLIESQSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1A4</accession>
    <name>I0A1A4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0773</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0773"/>
    <dbReference type="EnsemblBacteria" id="AFH42761">
        <property type="protein sequence ID" value="AFH42761"/>
        <property type="gene ID" value="FFONT_0773"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0773"/>
    <dbReference type="HOGENOM" id="CLU_1922694_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="131" mass="15823" checksum="C6852A37A81AD1AE" modified="2012-06-13" version="1">MRDNVLVIIKKSFQEIMEERGKILSTIEEKLKEEQSVENEEEILKLLEMNKNSRADLKNFLKTYHENINSEEEMEYYRTIIDFVRLVYMQIEEDLFERILERAERSIGPLKANKDWILKEAADIDFIYDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1A7</accession>
    <name>I0A1A7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42764">
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        <property type="gene ID" value="FFONT_0776"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0776"/>
    <dbReference type="eggNOG" id="arCOG05464">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138325_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="162" mass="18769" checksum="7C2BABB31165F6F4" modified="2012-06-13" version="1">MSIKKDQKHYDYGKDKYWGDKKGKTGGYEKKERFESGIKQEREGYEHHQNPNPLGEKCNNLCPLFWCTKRAYQIRRDPKTGRKYVFCTWTNDECIGAACQYASCKANYLLPNGECGYAKNKVAMAQPEKEDIVEDIEKEDLDIKTKGLISKKLGKKKLDDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1C1</accession>
    <name>I0A1C1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="321" mass="35400" checksum="D66CB87E08997EB2" modified="2012-06-13" version="1">MFKKDGQLIVIALGGNAFLQKGEKGTVEEQWKNVYVAAKEIVGLIKRGYKVVVTHGNGPQVGNVMEWIEALKDKIPPLTMDIAGAMTQGWIGYMLQQAIQNVLIEEGLDHHYRAVTLINQVIVKKDDPAWNNPTKYVGPYYYNEEEIEKLKKERGWVIKPDPRGGYRRVVASPDVVDNVEKEAIKLLYENDFIVIASGGGGIPVVADEIGRLEGREAVIDKDLGGQLLASVVDADIFIILTDVEGAYINYGKPDQKLLKELKVSEAKKLLEQGIFGAGSMGPKVKAAIRFAEKTGKPAYIGHLYKLQDILEGKSGTKILPD</sequence>
</entry>
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    <name>I0A1M3_FERFK</name>
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    </protein>
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    <organism evidence="2 3">
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42880">
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="88" mass="9765" checksum="EDC9953FBD85589E" modified="2012-06-13" version="1">MGIILLSIGIILLLFSFILAYNSFTNYTLAIPSNYSDLSSAIINSSYELIILAAKIAFLGIMVWISGIFIKYGVDAFRLEKFSQSSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1N5</accession>
    <name>I0A1N5_FERFK</name>
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        <submittedName>
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    </protein>
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    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccus</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AFH42892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_0904"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="62"/>
        </location>
    </feature>
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        <location>
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        </location>
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        </location>
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        </location>
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        <location>
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            <end position="451"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="486" mass="53006" checksum="17D91EAE2C1FFABF" modified="2012-06-13" version="1">MFVSLKRVLSWPQLLALGAAGIIGTSWAYMNTRFYSIYGPGGVILGYAIGTLMAFLVALAYAEMGSTIPKAGGEVAFVFPTLGPLGSFFVGWMFILSSVLAGAAFYVIGISLLLSWWLPSLYTIPIYSIAGVPVYLPALLLGITSAILILILNYRSVSLTGQAQLIMFIMLLLAGATILITALFKGSISNFANPSPFPQGENPLGLGLRFGLISIGYLSGFEGLPALAEEIKIKPRTFGLVIAGSVLVAGAFYMTMMFAGSLFVPWQQSYAIAHRGTIELMSRYSIWLGLIAWLASFLGLVTSWIPTVMTTSRMVFALAREGLFPSQFERIHPKYGTPTIALIFVTIISIIFGSLGEQGLIWFLDISGVGLGTCWLLSTLSMILTRRKYPNIPRYFKVPAGYLVGILGSGITLTVILVSIIPGTSLSLVWPYEYMILILWIVLGMIIYPFAKRRMNKLGIETVARNLLGEYYDVIYGKKEAKTETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Q1</accession>
    <name>I0A1Q1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Prenyltransferase</fullName>
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    </protein>
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        <name evidence="6" type="ordered locus">FFONT_0920</name>
    </gene>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0920"/>
    <dbReference type="EnsemblBacteria" id="AFH42908">
        <property type="protein sequence ID" value="AFH42908"/>
        <property type="gene ID" value="FFONT_0920"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0920"/>
    <dbReference type="eggNOG" id="arCOG00477">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_5_1_2"/>
    <dbReference type="OMA" id="MVVYPYG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HB_polyprenyl-transferase-rel"/>
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        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="299" mass="33489" checksum="122C2D1087966F12" modified="2012-06-13" version="1">MSLKWDPGEVKKKSSLNAILKLLRIEHTLLDLPFTYAGMALTHYPITLREVVLATFAVIGLRIAGMTYNNIADADIDRKNPRTARRPLLTGDVSFRDAWILVALGSLIYFASAFFLSFYAFILSPILYIVIMTYPFAKRFHPFPHLHLGLSLALIVFGGAIATSGEYVNNLMEAIESVPWTYFFAVLFWGSGFDAIYSIMDEEFDKSMKLGSVAARFGSRGALMFSLANYIISSLFLLIAWRLYNLGLLTLASMIISIFIMFYQVASCFIDIKNVPKAFNLNLIVGVIVSICILIDLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1R2</accession>
    <name>I0A1R2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="7">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">metG</name>
        <name evidence="11" type="ordered locus">FFONT_0931</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="7"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0931"/>
    <dbReference type="EnsemblBacteria" id="AFH42919">
        <property type="protein sequence ID" value="AFH42919"/>
        <property type="gene ID" value="FFONT_0931"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0931"/>
    <dbReference type="eggNOG" id="arCOG00810">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_1_2_2"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00098">
        <property type="entry name" value="Met_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="PTHR45765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="SSF57770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="9">
        <location>
            <begin position="5"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="10">
        <location>
            <begin position="408"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="333"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="568" mass="65710" checksum="28869EBF9EFAA5CE" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1R7</accession>
    <name>I0A1R7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="5">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lysS</name>
        <name evidence="8" type="ordered locus">FFONT_0936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 6">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0936"/>
    <dbReference type="EnsemblBacteria" id="AFH42924">
        <property type="protein sequence ID" value="AFH42924"/>
        <property type="gene ID" value="FFONT_0936"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0936"/>
    <dbReference type="eggNOG" id="arCOG00408">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_2_2"/>
    <dbReference type="OMA" id="EIFGEKC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="7">
        <location>
            <begin position="177"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="519" mass="59851" checksum="3F5B1A33C2ECD567" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1S8</accession>
    <name>I0A1S8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Protein translation factor SUI1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0947</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0947"/>
    <dbReference type="EnsemblBacteria" id="AFH42935">
        <property type="protein sequence ID" value="AFH42935"/>
        <property type="gene ID" value="FFONT_0947"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0947"/>
    <dbReference type="eggNOG" id="arCOG04223">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_6_1_2"/>
    <dbReference type="OMA" id="TIRDSWI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00604">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022851">
        <property type="entry name" value="SUI1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="104" mass="11603" checksum="C380181A1C9A29C9" modified="2012-06-13" version="1">MEKKDIDSICGGLPPELCEQLAKEQQLIKIRLEKRKFGKEVTIIEGIDEKEVDIKKLASQLKTKLATGGTAKNGRIELQGDHRSALKEILIQFGFPEESIIVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1S9</accession>
    <name>I0A1S9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="8">V-type ATP synthase subunit K</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0948</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0948"/>
    <dbReference type="EnsemblBacteria" id="AFH42936">
        <property type="protein sequence ID" value="AFH42936"/>
        <property type="gene ID" value="FFONT_0948"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0948"/>
    <dbReference type="eggNOG" id="arCOG02455">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_3_1_2"/>
    <dbReference type="OMA" id="YRYIMIV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_C" evidence="7">
        <location>
            <begin position="47"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="110" mass="11036" checksum="767CDCED6643A508" modified="2012-06-13" version="1">MLELQGKSLNRLRLLLLFASILLISIIGTMAYAQTTTGSETAGYKAIGAGLAIGLAGIGGGIAVGRTGAAGLSVLSEKPEAFGTVLLIVALGEGIAIYGLIIAILVIIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1V5</accession>
    <name>I0A1V5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerate kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42962">
        <property type="protein sequence ID" value="AFH42962"/>
        <property type="gene ID" value="FFONT_0974"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0974"/>
    <dbReference type="eggNOG" id="arCOG04170">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_032279_1_1_2"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:glycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GK-like_C_sf"/>
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    </dbReference>
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        <property type="entry name" value="MOFRL_protein"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="DUF4147" evidence="2">
        <location>
            <begin position="13"/>
            <end position="257"/>
        </location>
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        <location>
            <begin position="342"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="454" mass="49554" checksum="9508D26526A08126" modified="2012-06-13" version="1">MVIKTGKKMPEKLETILKESVRLADIQYYMKKRVRLEGECLIIKNEKENKEYKITIKNKRVHLISFGKASQKMAEFALNLLGSRIIDGIVVKLKFAEKISEFPQNIKVIEANHPVPDSGSIEAAKSILNLISNASEDDLMLFLISGGGSAMVELPIDPITLEDAEKAFSLLIRSGATIHEINAVRKHISQIKGGKLAKKAYPAEVVSLIASDVPGNYIDVIASGPTAPDMSTYSDAYRILEQYEILDKIPKSVLEVIEKGLRGEIEETPKPLDKVFERAHNFLIAAPSDLAKEVSSYVSKIGYNSYVLTSILQGESGEVAKALSSIAIDTKKGNTSFALPTALILAGETNVKVKGSGKGGRAMELVAYFSREIAGIDGISIFAIDTDGMDGSTTSAGAFADCNTWRKIFKKYGLKAFDELRNNNSYELLDSLGYTIYTGPTGSNLNNLICILID</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1W2</accession>
    <name>I0A1W2_FERFK</name>
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        <submittedName>
            <fullName evidence="4">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ordered locus">FFONT_0981</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42969">
        <property type="protein sequence ID" value="AFH42969"/>
        <property type="gene ID" value="FFONT_0981"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
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        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
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        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fe-ADH"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-ADH" evidence="3">
        <location>
            <begin position="14"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="385" mass="42787" checksum="ED83CFB790FB02CD" modified="2012-06-13" version="1">MSSTKDFSLSFRETTLYFGINSTERISRSIKGFRRALIVTGKTSAKKSGALDDILKILNENDIEYTIYDSVTSNPTVDKIEEITEKGKIFDTDLIIAIGGGSVIDSAKFASVILSIGGNPVDYIKRKIKPVSHTFLVAINLTHGTGTEVDRYAVATISETKEKLGSSIAYPNISVDNPRYMVSLSPQQTLFTSIDAFYHALESSIVESSNPYVQDLSEKSAYYIKTYIQVAMKNPSDIEARYWLLYASMLAGISIDLAGTSIIHGMEHGLSGVNPSLEHGAGLAIIGPLFLPLLYKAFPENSWKVMKVLDPSLRPTPEDAEKAGKILDEFQKSIGFNYALKDYGFDKEWLKDAVEAGWRIFEPRIPKDKFILTKEQVYNMLLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1X8</accession>
    <name>I0A1X8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="322" mass="36874" checksum="E5E9259E1D217DAA" modified="2012-06-13" version="1">MKLRKILRSIRNSHIKANCMKCTKCGKKEAIFKVPYTNYFLCADCYSTYFYKRLKRNLSRSNVLSYGGKLSVFVPRSFTAEGLVLIKILRQIERKYNNKLTVIFESSPIVRKSLSVLGKLPSEVFYSLEIVDNEEKDISHEGMLGRLRVVRGMLSLLDKNITGNAIVLPLCQDVLILLELSSILGSIVEGINEGVLVISSSNGTNFINAFSGISCYETSFMAYYNFPEIYEFQIRNLNYEKNIYEKYTERILTDASRMQSGEVIFSVNKSLSWLYKERGSMLKKCKYCGGTSSSEVCRFCKTYLDMYISEKNTPPFKLISLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A245</accession>
    <name>I0A245_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1064</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1064"/>
    <dbReference type="EnsemblBacteria" id="AFH43052">
        <property type="protein sequence ID" value="AFH43052"/>
        <property type="gene ID" value="FFONT_1064"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1064"/>
    <dbReference type="eggNOG" id="arCOG00610">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="PKGGYKA"/>
    <dbReference type="Proteomes" id="UP000007391">
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        <property type="term" value="P:regulation of transcription, DNA-templated"/>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CBS_dom"/>
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        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="UCP005063_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="177"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="239"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="294" mass="32488" checksum="71B7EC9A3D918FF4" modified="2012-06-13" version="1">MYELTQTQREVLLALIKLYEQNNRLVKSIEIAQQIGKDEGTVRNIISSLRSLGLLESKTGPSGGYMPTLKAKELIKSYGIVTYGSLRIKKNGNETNVTAYSIEIMDVLNPAGAKAILKANGNLDELKEGDIIRLGPTDYNRLLIDGEIQHIDRSTGQIAILIKRLVSIPRENVGEVATKNLVTLTSQMPLREASSLLFREKIRGAPVIENERIVGIITTTDIAKAYSEGNVKAKVEDYMRKHVVTIREDEDIMDAVRIMELHGVGRLIVVNAVGEPKGIVTRTDILKRISALGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A248</accession>
    <name>I0A248_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">7-cyano-7-deazaguanine tRNA-ribosyltransferase (Archaeal tRNA-guanine transglycosylase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1067</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1067"/>
    <dbReference type="EnsemblBacteria" id="AFH43055">
        <property type="protein sequence ID" value="AFH43055"/>
        <property type="gene ID" value="FFONT_1067"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1067"/>
    <dbReference type="eggNOG" id="arCOG00991">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PUA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TGT_C2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PUA" evidence="2">
        <location>
            <begin position="88"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="160" mass="18216" checksum="B8039CE1555A470D" modified="2012-06-13" version="1">MRIKREKPSKFELIQLKSVIAYQFGKEAVESIFKSNNSIEVSRYSTGRIRTVYINGEEALYFNPKIGLFSLSMYGASLIFPSIPKETKRIAVITEVFENYTKKTLLAPAVAWSTNDIRDGDEVFIVNENGELLALGKALLCHEEIKKIKRGKVALIKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2A2</accession>
    <name>I0A2A2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-superfamily hydrolase, subfamily IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1121"/>
    <dbReference type="EnsemblBacteria" id="AFH43109">
        <property type="protein sequence ID" value="AFH43109"/>
        <property type="gene ID" value="FFONT_1121"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1121"/>
    <dbReference type="eggNOG" id="arCOG01214">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="MADEECL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="242" mass="27393" checksum="2F3462981BF4255C" modified="2012-06-13" version="1">MTELSVIDMDREEVEALVFDYDGTLSPIGSEAGVSRELLDILNLLKNMYKLIVASTRDCRFLMEKIGFFDAFVCSNGLEAIIGDVVVHKKGVLQIERTKKLEELKKMADEECLKVEEKMSLDGKLIGLGISWRRCGEKPNCIDEIIREAIRGELVIEWYQRPFVEVYVDKAGKMEGLKIANAILNIERFAYFGDSESDLESLKNASISVFVRNSYNSHLNPPTTYTVNEGELSSFLAKKFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2B1</accession>
    <name>I0A2B1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribonuclease P protein component 2</fullName>
            <shortName evidence="2">RNase P component 2</shortName>
            <ecNumber evidence="2">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Pop5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rnp2</name>
        <name evidence="4" type="ordered locus">FFONT_1130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Consists of a catalytic RNA component and at least 4-5 protein subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1130"/>
    <dbReference type="EnsemblBacteria" id="AFH43118">
        <property type="protein sequence ID" value="AFH43118"/>
        <property type="gene ID" value="FFONT_1130"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1130"/>
    <dbReference type="eggNOG" id="arCOG01365">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1582839_0_0_2"/>
    <dbReference type="OMA" id="RYIVFAI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:ribonuclease P complex"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:tRNA 5'-leader removal"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
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    <keyword evidence="1 2" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="168" mass="19390" checksum="1171F149362B5892" modified="2012-06-13" version="1">MGSFEYLAIAEAVAILLLSLGIFIIYIRFKKIERGLTTLNKKFSLISSLENWNKEEMVKKEAKVKRKKRYIVFSITSDADIDYSEIADSILTALGKIYGEPFISKSGYHFIVYYSDIKKGIVRVYREYADNIIAIFPFARRYAKKDFMIVPVKVCGTVKKAKKFLNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2C4</accession>
    <name>I0A2C4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dephospho-CoA kinase, CoaE</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">FFONT_1143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1143"/>
    <dbReference type="EnsemblBacteria" id="AFH43131">
        <property type="protein sequence ID" value="AFH43131"/>
        <property type="gene ID" value="FFONT_1143"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1143"/>
    <dbReference type="eggNOG" id="arCOG01045">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096329_1_0_2"/>
    <dbReference type="OMA" id="DYMIVNE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="195" mass="22147" checksum="0382A1AAC94C9361" modified="2012-06-13" version="1">MLGDMRKLILITGMPGSGKSIVSSYFKSRGYTVYSMGDIVRNIAEERGVEKTLENLLSIAQEIRNKYGPSGVAKLMIPILEKEKSETVVIDGVRSINEIGEFKKVSKCINIIAVYSPPYMRFERLLYRGRPGDPRSFEELIERDLKELSFGIGNVISLSDFMIINDESPSKVIDYLKSKEDEICNCKKESVWKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2E2</accession>
    <name>I0A2E2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FFONT_1161</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1161"/>
    <dbReference type="EnsemblBacteria" id="AFH43149">
        <property type="protein sequence ID" value="AFH43149"/>
        <property type="gene ID" value="FFONT_1161"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1161"/>
    <dbReference type="eggNOG" id="arCOG01481">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043773_0_0_2"/>
    <dbReference type="OMA" id="EVRWTLD"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01571">
        <property type="entry name" value="NAPRTase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035809">
        <property type="entry name" value="NAPRTase_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="11">
        <location>
            <begin position="53"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="10">
        <location>
            <begin position="120"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH43149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="398" mass="45017" checksum="7A13689BE637D83B" modified="2012-06-13" version="1">MKFLRRKFYIATDEEILNGEATDVYFTRVEKILESAGLKDKKVRAEFHTYGLPKDYSWAIFAGLEEALNVLENHKVDVYALPEGILFREREPVMLIEGEYYDFALYESIILGILRHYTSIATKTARIKYAAGNKQVLFFGLRSLHPALAPLADRAALIGGADSVSGVLSKKYLGVEPSGTMPHSLMIIVGDQAKAWKLFDENIDESVPRIILVDTFWDERIETELAMKTLGKKLYGVRLDTPSSRRGNFRKIIEEVRWALDLNGFKNVKIIASGGLNEEDINELKDIVDAFGVGTSIAFPPSVDISMDIVEVYENGEWIPRTKRGKLPGAKKIYRCPGFKDQILPWNKSPEKCEDGSEPKLLLKKYIENGKLIEPLPDLKEIRKLVLSQLNELANITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2E4</accession>
    <name>I0A2E4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1163"/>
    <dbReference type="EnsemblBacteria" id="AFH43151">
        <property type="protein sequence ID" value="AFH43151"/>
        <property type="gene ID" value="FFONT_1163"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1163"/>
    <dbReference type="eggNOG" id="arCOG06100">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173012_0_0_2"/>
    <dbReference type="OMA" id="WALYLRR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="96" mass="11514" checksum="66F21E0F69DAD737" modified="2012-06-13" version="1">MEMEKKYNQNERMKLEIISMIDENPSNWIKAAYFSDSEVSKIMEILYKLWEENNEKGFPIDYASNEQLKALYSKAKRYSSMKEEEAMKTVLERVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2H3</accession>
    <name>I0A2H3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_1192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1192"/>
    <dbReference type="EnsemblBacteria" id="AFH43180">
        <property type="protein sequence ID" value="AFH43180"/>
        <property type="gene ID" value="FFONT_1192"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1192"/>
    <dbReference type="eggNOG" id="arCOG00113">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_2"/>
    <dbReference type="OMA" id="MDTHGFG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="3">
        <location>
            <begin position="43"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="396" mass="43742" checksum="C40E768366057EC0" modified="2012-06-13" version="1">MAKGWVKDLYGKRLKELLERGEYWEIKKLMGPTGPHAIVEGKEVIMFATNNYLNLANDQRLKQAAVEAIEKYGWGPGAVWAIAGFHEILSELEKKIAEFKRTEAGIFFPTGYATNVGTIPTLVETGDLILSDQLNHGSIIDGIRLSRAEKIVYNHCDVADLEDKLRKAHGKYNKILIITDGVFSMDGDIAPLKDISKLAEEYNAIVYVDDAHGEGVLGEGRGTPAHFGVDDKIDIHMGTFSKALGSSGGMVGSDREIIEYVRNTARSWLLSTGPSPGAIAANLKALEIVMSQEGKERVRRLHENANYFRKELQSIGFNTGKSETPMIPVIIGDTKKARELAKALFDDGIFVVPIVYPMVPRGTERTRNEVSAGHTREDLDKTLAAYEKWGKKLGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2I0</accession>
    <name>I0A2I0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TatD-related deoxyribonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1199</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1199"/>
    <dbReference type="EnsemblBacteria" id="AFH43187">
        <property type="protein sequence ID" value="AFH43187"/>
        <property type="gene ID" value="FFONT_1199"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1199"/>
    <dbReference type="eggNOG" id="arCOG00891">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_5_2_2"/>
    <dbReference type="OMA" id="DGPYEYR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="247" mass="28786" checksum="4CDBF5CFC86A3068" modified="2012-06-13" version="1">MISAASFKYIDAHTHAYEYEEKSLSNYEKEFLLIAVSDDAESSKRTVKLSEDFKAVYPCVGIHPWNVSRSSREDIKTIENMLENSESPCLGEVGLDARMHPETFERQKEFFASFLDIAREYDAILNIHTLDAWELVYELITKKEINRAIFHWYNGPIELMQKIQETGYYISINVALKMQKKHEEVARKADLKKLLTESDGPYIYKGTLLKTEMIPEAIKYLAEIKGVGENYLREKIYENFFDLVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2K5</accession>
    <name>I0A2K5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)</fullName>
            <ecNumber evidence="2">2.5.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl diphosphate synthase</fullName>
            <shortName evidence="2">UDS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Undecaprenyl pyrophosphate synthase</fullName>
            <shortName evidence="2">UPP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">uppS</name>
        <name evidence="3" type="ordered locus">FFONT_1224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tri-trans,hepta-cis-undecaprenyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27622"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:60388"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="2.5.1.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1224"/>
    <dbReference type="EnsemblBacteria" id="AFH43212">
        <property type="protein sequence ID" value="AFH43212"/>
        <property type="gene ID" value="FFONT_1224"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1224"/>
    <dbReference type="eggNOG" id="arCOG01532">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_2"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
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        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH43212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="267" mass="32066" checksum="5ACF0E3D0E5F332B" modified="2012-06-13" version="1">MQFLTKVFERFEEEILKPVYKLYEHYLWNQIKDNQMPQHIGIIPDGNRRWAKRHGYEYTFGHKMGYEKVSQVLDWIWNLNVKAVTLYVLSTENCLKRSEEEKQNIFQLLYMGLEQLENDRRIYDSKVKVKIIGNFELIPDWIIKKAKEVEEKTEKNELRILNIAVCYGGRHEIIEAIKKIASDYKKGVISLNEIDENKVSSYLFTSDSPDPDLIIRTSGEERISNFLLWQSAYSELFFTDVYWPEFRKIDLWRAIRSFQKRRRNFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2L0</accession>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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            <begin position="8"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="326" mass="37281" checksum="F1B61EB7851AFADF" modified="2012-06-13" version="1">MEVRKVQRLGSSSLIITLPKSWVNKVGIKAGDSVYIIEREKELRIIAFENEEVYAVVEFEKNQLIEEIKNKAKCLMYAGIPYFILKSNELITDDIAREVMSVKDENKDYEIKKVDPFGISFKLVSKMTDEDIDAILRESLISFEGAINKLLESLTSFNEKSFDELKKVKEAFELRASNIKHFFNIGDLSAEDPILEKKAKLKMTIYYSIYNILRNLLDTLLVLIEIGEEDISKNEVEYFKNIFGLYLSLIWEVAGAITNESLKRIEYANKLFTNISNNISEFLANGSLSSLSLKMASAIVYSLSYVKTVINDSTCYIHLKDAHINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2L6</accession>
    <name>I0A2L6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="175" mass="20709" checksum="C8CEB5F3BE671584" modified="2012-06-13" version="1">MFKFNCLLCGAVCCTFKSEEESPLVFPWEKRRLERLNKSSMFEPYIIYKINNEEIGVLMYRWKIEGRCLFLNREGRCTIHNSKPLSCKMFPLIIGLDDFTLRVSADCEVVKNHINDLETSDPKSSFPAEYPHAMKVFELIIKYDREAKKKGWNREIFKKEYSAHRIIDIDNLIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2M4</accession>
    <name>I0A2M4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Tyrosine recombinase XerA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">xerA</name>
        <name evidence="7" type="ordered locus">FFONT_1243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 'phage' integrase family. XerA subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH43231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1243"/>
    <dbReference type="EnsemblBacteria" id="AFH43231">
        <property type="protein sequence ID" value="AFH43231"/>
        <property type="gene ID" value="FFONT_1243"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1243"/>
    <dbReference type="eggNOG" id="arCOG01242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_2_2"/>
    <dbReference type="OMA" id="ERMVYFD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02055">
        <property type="entry name" value="Recomb_XerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033686">
        <property type="entry name" value="XerA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026870">
        <property type="entry name" value="Zinc_ribbon_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13240">
        <property type="entry name" value="zinc_ribbon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56349"/>
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        </location>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="353" mass="40109" checksum="628F7A1F27B9EBF3" modified="2012-06-13" version="1">MLTKAGDEIKEMSSEQAAEYFLSLLSASGLSEKTIRSYRAAIYDFLNFSKVKRLNEISQNLILNWINYRLKNGFEKRGGKEEKRKIQSTMHYYTLFLRKWLTWAGFDSKIVPIVKKPQSGEISALTKEEIDKLFSSSRDLLDMLIISLLFETGMRANELLSITADDVDLTDGEISVKNAKYGKVRTVFLGENSKFLLAERVKNISSGERVIPLSYNGLYKRIKSLAKRAGIPLEKVRPHILRHTFATEAVRSGMSLPALQKILGHSDIKVTQIYTHLLKDDLKKEYYSKFTSSREKTMSKNDESSAFNDENIHEDIKFCPNCGKKLPPGSKFCPFCGYRLPLVGSDGSNQIET</sequence>
</entry>
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    <reference evidence="3" key="1">
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AFH43239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="237" mass="27758" checksum="48207F1FB35FEB8D" modified="2012-06-13" version="1">MSPMLCFSLTEEQYKKLQNLANSMGYSDVGEFVKQNIFNLQPSKLPLTQQEVKTAQEKIQLERDQFQNLIRTIQDLINPFTAKIDELTRSFAELKEEMERIESKISEVETRKELPKQKFQAKETQSQKVKPKAIERLKSEGVVFQKDLSWLNTPRAFFERLRKDGAVVMTLGNEYVAIDRTFWEDFKNELSKINERNADKVSKMLSEKMAILFKRLLEEGKVMYVENEGWVVEEEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
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        <lineage>
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    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the PDCD5 family.</text>
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    </dbReference>
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    </dbReference>
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    <feature type="coiled-coil region" evidence="3">
        <location>
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            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="116" mass="13870" checksum="B8474194E3D96D49" modified="2012-06-13" version="1">MSDEYNDEELAEIEQRKLLELQRRMEMEERRRRATEAEAQKQEILRKILTPQARDRLNNVKLVRPELAEAIENQLIVLAQSGRITEPITEEQIKELLAEITTRSRKEFNIKIREKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2R6</accession>
    <name>I0A2R6_FERFK</name>
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        <submittedName>
            <fullName evidence="3">Component HyfH of membrane-bound [Ni,Fe]-hydrogenase</fullName>
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    </protein>
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        <name evidence="3" type="ordered locus">FFONT_1285</name>
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        <lineage>
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            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43273">
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        <property type="gene ID" value="FFONT_1285"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="179" mass="19947" checksum="F47D349E76492BA3" modified="2012-06-13" version="1">MSNLKTITKGIKYGIATVKYPFVPEKVEEDYRGKPVLNFDLCIGCGSCSLACPPDAITFTRKENHAEWKIFYGRCIFCGRCEEVCPVGAIIQNEEFELASKKKDDLEVVANLKVAKCASCGKSMNVTEREVKYVIDVLRSSLPQSKAEVISELASLCSECKRKRFIEKIIKTYGKGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2S5</accession>
    <name>I0A2S5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">FFONT_1294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1294"/>
    <dbReference type="EnsemblBacteria" id="AFH43282">
        <property type="protein sequence ID" value="AFH43282"/>
        <property type="gene ID" value="FFONT_1294"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1294"/>
    <dbReference type="eggNOG" id="arCOG05995">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2629540_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="77" mass="8741" checksum="8E603484B6A8CAFD" modified="2012-06-13" version="1">MQKNIKQANFLDIESMALGNKLASVKIENCGEETSKIVAEDNLGNIYETPCEQKKIVSKSYMIINNYIKWSKLVLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2T7</accession>
    <name>I0A2T7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphate regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1306"/>
    <dbReference type="EnsemblBacteria" id="AFH43294">
        <property type="protein sequence ID" value="AFH43294"/>
        <property type="gene ID" value="FFONT_1306"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1306"/>
    <dbReference type="eggNOG" id="arCOG00318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069302_1_0_2"/>
    <dbReference type="OMA" id="SMHRDAT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="3"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="323" mass="36811" checksum="7D03D0571C1DA98D" modified="2012-06-13" version="1">MQIVGGSTYILSLPKSWAEKVDLKEGEELFVEELSNQALLIYAPERREHFSKAEISFTCKESRNFIERTIIAQYLAGKKEIVLHASDVECKKTLSSIADSLKKKVLGLEILEETSNDIVLGAILDTTFSDITHVINSMMKTIIYMLEDLAIGLRKNDLKIIKDIYQRDDYIDRLYLYSIRYLVNIYNMPTQERINPSSSVHYALATKSLERIGDHVSAISKNLEVELVQSNINDKEKEGILNLINSIKDLESQILKLVLKFDGELLNEITEKAINLMNVESELRVSLLKYSVNLSYVAESLRRIIAYSIDLLESVLDINVLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2U8</accession>
    <name>I0A2U8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1317</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1317"/>
    <dbReference type="EnsemblBacteria" id="AFH43305">
        <property type="protein sequence ID" value="AFH43305"/>
        <property type="gene ID" value="FFONT_1317"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1317"/>
    <dbReference type="eggNOG" id="arCOG06075">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125813_0_0_2"/>
    <dbReference type="OMA" id="WYPFVKL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
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    </dbReference>
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        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="65"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="167" mass="19353" checksum="D2C6EA156F2ED4F3" modified="2012-06-13" version="1">MSSNENDIRDLIDRLLTEIASKSSIDRKKFPVGPFSPNGIYYFDNGEWKLLRRDGLPFQPGENGDGIYVVYFDNTQCSACRRFDPEWYSFVEEYKDRGKFYIILCDWFARECDSKAASRTFFINEVRASPTTMIFLVKEGAIVKNERIEGSVKKEELASKFKSFISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2V4</accession>
    <name>I0A2V4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Electron transfer flavoprotein, alpha subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1323"/>
    <dbReference type="EnsemblBacteria" id="AFH43311">
        <property type="protein sequence ID" value="AFH43311"/>
        <property type="gene ID" value="FFONT_1323"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1323"/>
    <dbReference type="eggNOG" id="arCOG00448">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_1_1_2"/>
    <dbReference type="OMA" id="YKHVWVF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="2">
        <location>
            <begin position="9"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="330" mass="36312" checksum="71BF581DA0BB3923" modified="2012-06-13" version="1">MSQEDYSGFMVFAEQHDGVIHPVTFELLGKARELAEKKGSKVYAALLGYNVGSLSSELIYYGADRVYVVDSEKLKVFDVMHYKDAFLKVIEKAKPEAILMGATNTGRTLAPRISAALKTGLTADCTDLFIDEKGNFIQVRPAFSGNIFAHIGTKTKPAMATVRYRTFKAIEKDTSRKGEVEKVEYSGPDDTGYKVLEKIPREKVNISDAEVIVAVGKGLKKKEDLKIIEDLAKLLNATVGASRPLVDDDWISRDHQVGFSGNIVKPKIYIAIGISGSPQHTVGMKDSGIVISINKDPNAPIAEYSDYFIVGDLYEVVPKLIEEIKKKKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2X7</accession>
    <name>I0A2X7_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Phosphoesterase, RecJ domain protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">FFONT_1346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1346"/>
    <dbReference type="EnsemblBacteria" id="AFH43334">
        <property type="protein sequence ID" value="AFH43334"/>
        <property type="gene ID" value="FFONT_1346"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1346"/>
    <dbReference type="eggNOG" id="arCOG01565">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070736_0_0_2"/>
    <dbReference type="OMA" id="CHHNADP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="314" mass="35633" checksum="95378F1C0FE99A4C" modified="2012-06-13" version="1">MIVTHKQADVDAFSSALALKRLIVREFGSQSGEIKVVFPESISSEAERLEKVLLSKQENFEYLNEINEVNGETIIILDTASESQLPNFQEILKGYTFLIDHHYYNSIKKFVSEYYIDRTAYSTSELIASIFPEGLLDEATSCLLLAGIVFDTNRFKRSSESTFICASKLSSRCNYNKLISEIETREEDVSKRMAKLKALQRLSLLRKGELIIAMTHVSSFESDVASSILREGADISLVISDKDFGLRIVLRSKSEVEDEVLRKIREVVERLAEGKFGGHRESMVLESNIRIEKREIESLMKKIKEELQPSLGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2X8</accession>
    <name>I0A2X8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Elongation factor 2</fullName>
            <shortName evidence="8">EF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fusA</name>
        <name evidence="10" type="ordered locus">FFONT_1347</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1347"/>
    <dbReference type="EnsemblBacteria" id="AFH43335">
        <property type="protein sequence ID" value="AFH43335"/>
        <property type="gene ID" value="FFONT_1347"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1347"/>
    <dbReference type="eggNOG" id="arCOG01559">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_11_1_2"/>
    <dbReference type="OMA" id="GVMTQTE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_A">
        <property type="entry name" value="EF_G_EF_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004543">
        <property type="entry name" value="Transl_elong_EFG/EF2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00490">
        <property type="entry name" value="aEF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="18"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="93"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Diphthamide" evidence="8">
        <location>
            <position position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH43335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="736" mass="82118" checksum="81B475A1799BE771" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Y5</accession>
    <name>I0A2Y5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
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        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0029"/>
    <dbReference type="EnsemblBacteria" id="AFH42025">
        <property type="protein sequence ID" value="AFH42025"/>
        <property type="gene ID" value="FFONT_0029"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0029"/>
    <dbReference type="eggNOG" id="arCOG01871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098907_1_0_2"/>
    <dbReference type="OMA" id="PMITLMY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="176" mass="19219" checksum="9C65715D7DAAD52B" modified="2012-06-13" version="1">MAGGRGERLGGLKKPFLIICGKRLIDVSIDAAEKVRGNGKVYVCVRGEDLGKVEGREGVQAVECPGLGYVEDLSLILKRVTFPALILPGDMPFLSREALERFLDKALNSKADVVTLVKMRSGSAEETGISLFNREGGSWENVYFNEDRDLLDIDTPEDLKKAVELCGSTEEGEKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ95</accession>
    <name>H9ZZ95_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HTH_ARSR domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0058"/>
    <dbReference type="EnsemblBacteria" id="AFH42052">
        <property type="protein sequence ID" value="AFH42052"/>
        <property type="gene ID" value="FFONT_0058"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0058"/>
    <dbReference type="eggNOG" id="arCOG01446">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107894_1_0_2"/>
    <dbReference type="OMA" id="EKFCYRA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010163">
        <property type="entry name" value="Csa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01884">
        <property type="entry name" value="cas_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="231" mass="26331" checksum="4345CB2783D15655" modified="2012-06-13" version="1">MKKSVIFTVGFDPKFIFKTILEQPDADLFIAVINNDKNEKVLKALDEITTFIKEYVERSVEVWEIDFSSPHEAFHEISKRLLDLEESSIIIDVSSGMRLIGIITLGAAIASVDPYRLQIRIWTEDLKGRYDISFLTYITVKPFLSSLSLRVLDLISRKEALTLDDISRELGKSKPTVFRSVKLLRQLGLITPEKRGRKDLYKLTPKGMVISRAFRNVLPSEGEKNHSDGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZA5</accession>
    <name>H9ZZA5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas2</name>
        <name evidence="9" type="ordered locus">FFONT_0068</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0068"/>
    <dbReference type="EnsemblBacteria" id="AFH42062">
        <property type="protein sequence ID" value="AFH42062"/>
        <property type="gene ID" value="FFONT_0068"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0068"/>
    <dbReference type="eggNOG" id="arCOG04194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_2_3_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="96" mass="11074" checksum="6F1EDAD1A2CB320F" modified="2012-06-13" version="1">MGFYIIVYDIGDQGKRQRVVEILEKWGLRRIQRSAFVGYVQEGRAKDIAREIEMTIDLEKDVVHIVQIERKEWNRAIVVGTSKWSAGSPEGSVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZA9</accession>
    <name>H9ZZA9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AFH42066">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="439" mass="50036" checksum="27AFCDD7F7ABA055" modified="2012-06-13" version="1">MKLIIPYSPSRQVLLGTLGYEIATGEKFEEIILTSEQEPEEMLEIIEKISRALGAKLSLRVLGRDPRSWARLEIPEDTILDITPGRKIYASVLLQKCLVSRSCRARYLYIEEEKKYGYKFFGYMPKWSFKFIELYPELNLLKLDASKLKEVHISDPQEHLQKVAPETIQAIVNLYSQSGANEFSIEACGGRAEFEFTEESLILKSYSSFGSGDLETFEEVLSSSLELENKEEVYSKLSKCVSEGGIIVPDTNVFIHGRIFDYLKSQYKYVEIMKPIWAELLPQALEEKETSLGRKKLLGVIRATALNKTIPTMDRMLKGDVEIINSLKKLLDERKKVCFLTSDVRLSLAVSNVLRGDEVLMRAPFLEEGRKFCAEELYSFFLNLAFQCKGFKLSMAERTFSFELGRIGELGTGIPNLKLKGPERADDLAFLDMIVRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZG0</accession>
    <name>H9ZZG0_FERFK</name>
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        <recommendedName>
            <fullName evidence="1">PINc domain-containing protein</fullName>
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        <name evidence="2" type="ordered locus">FFONT_0125</name>
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0125"/>
    <dbReference type="EnsemblBacteria" id="AFH42117">
        <property type="protein sequence ID" value="AFH42117"/>
        <property type="gene ID" value="FFONT_0125"/>
    </dbReference>
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    <dbReference type="OMA" id="RERSSHN"/>
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        <property type="component" value="Chromosome"/>
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        <property type="entry name" value="PIN-like_dom_sf"/>
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    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42117.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="129" mass="14915" checksum="31EA32D8C7E7D8F8" modified="2012-06-13" version="1">MKKSSDFKTVYIFDTGAFLTGLHLSFPFQIYTVKEVVDEVKDFENKSKLEYTLSANRIIIEEVEDDLRSLNKKLSKALSKADRKLINLALKKKGEGFNVVVFTDDYKIQEALLSVGIEFKPIRYRSIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZH5</accession>
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    <organism evidence="4 5">
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        <lineage>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0140"/>
    <dbReference type="EnsemblBacteria" id="AFH42132">
        <property type="protein sequence ID" value="AFH42132"/>
        <property type="gene ID" value="FFONT_0140"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0140"/>
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        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OMA" id="PGETKFR"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:nucleic acid binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
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        <property type="project" value="InterPro"/>
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        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
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    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
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        <property type="entry name" value="tRNA_SAD"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="256" mass="29405" checksum="5CE9EEC4AF0060B3" modified="2012-06-13" version="1">MVNLKEEARKFSPTEKVYLENSYLKEINANLLSILMESKNKAYLVFDKTIFHPKSGGQESDTGTIYDNERLFEVKKVLEVDGVAFHYANIQKNSGIQEKGEIFRLKLDWERRYKIMRSHTAGHILDYAVMKVTGKKVNTIEANHASIGSYIKYEHINLSHIQLEMIEKTANEAVKAGISVNVRYVKREELEKFVFNAPNLERLPDVGIYRIVEIQNINSIPCSGTHVKNTSEINYIKIKGVKEEDDGTVIFYETIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZI6</accession>
    <name>H9ZZI6_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
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    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0151</name>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0151"/>
    <dbReference type="EnsemblBacteria" id="AFH42143">
        <property type="protein sequence ID" value="AFH42143"/>
        <property type="gene ID" value="FFONT_0151"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0151"/>
    <dbReference type="eggNOG" id="arCOG00500">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031317_3_2_2"/>
    <dbReference type="OMA" id="HEASCLE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="20"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="253" mass="27950" checksum="E9FA22ADBCCA39C9" modified="2012-06-13" version="1">MEILFIGTGAGGSPGSNRWRASSVVFSEETALLIDCGVGCHYRLGERGLLKEIDAIFITHYHMDHFLGLPELLFQAHIEKRSKPLKIIGPNGIESMIRTAAPHLFSNISFSFSVETVKVHETYKLNDLTLIPAPACHTIESYGLKILDKRGNSLGFSSDTSEPCESLISVLKGVKYLVHEATCDERNKDLCHKYGHSTVLEAIEAAKAIGAEKLILNHIDENFNNLNSSYQILPKSLNGKVIFANDLDRIILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZL0</accession>
    <name>H9ZZL0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42167">
        <property type="protein sequence ID" value="AFH42167"/>
        <property type="gene ID" value="FFONT_0176"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0176"/>
    <dbReference type="eggNOG" id="arCOG10989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1598947_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="166" mass="19675" checksum="6A7265B95B61B1FF" modified="2012-06-13" version="1">MEEFKEYLKCLRDIEYETYFVYNMLYSKIEKEDIKHIFLYIGMDSYKHYLIYDRLLNGESSDEDLCRDILGDLFMDSLNSIKQLKASVFKIDKISDEQIYEIISMLVNYEGGVYEEALSSIITRILGENLKGGIKKIFELIEEDEKKHEKLLMDLLIGKTKKYELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZL2</accession>
    <name>H9ZZL2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thermopsin, endopeptidase A5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0178"/>
    <dbReference type="EnsemblBacteria" id="AFH42169">
        <property type="protein sequence ID" value="AFH42169"/>
        <property type="gene ID" value="FFONT_0178"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0178"/>
    <dbReference type="eggNOG" id="arCOG03439">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03672">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334538_0_0_2"/>
    <dbReference type="OMA" id="WLQNVIQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007981">
        <property type="entry name" value="Peptidase_A5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05317">
        <property type="entry name" value="Thermopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="796"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="820" mass="90178" checksum="B992718C59102458" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZM7</accession>
    <name>H9ZZM7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor synthesis domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0193"/>
    <dbReference type="EnsemblBacteria" id="AFH42184">
        <property type="protein sequence ID" value="AFH42184"/>
        <property type="gene ID" value="FFONT_0193"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0193"/>
    <dbReference type="eggNOG" id="arCOG00216">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_2_2"/>
    <dbReference type="OMA" id="APMPAGC"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="3">
        <location>
            <begin position="181"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="406" mass="44846" checksum="9A9718A0E035CC7A" modified="2012-06-13" version="1">MNFAYEYNFLPIEDAIKILLESVKIRKGGFKTHINESIGMILNESIVSPVDVPEVNRSAVDGFAVCSDEVSLASFNNPIILALKKNGEGFDCSSTVQVNTGMPIPSPYDSVVMKEDARIYEHSVHILKSVPKYGNVSKKGEDLKKGDIIAEKGQILKPWHISLFASVGIKEVEVLEKIKIGIIATGSEVVDINNTHKKGEFYVFDSTSRLIYASLIEHNFLQLTHYGVVEDEKEKIVEVLKKALEENDIVITTGGTGPGERDLTFDAILNLNGQILSRGIAMRPGRPTTIALIEGKPIFLFSGYPVASFVALRFIFLPFLSKYFGTKGLENIEIPAKLTKRVTGGIGYDTFIRVNVFRCGDELCAEPVMLRGSGILSSLLKTNAFMIIPRNVEGFEEGETVWVHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZM9</accession>
    <name>H9ZZM9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdenum cofactor biosynthesis protein C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
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            <end position="143"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01967"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="145" mass="16392" checksum="0AC3030B70EB57BB" modified="2012-06-13" version="1">MCTKMVDISEKESVYREAMATGFIKLKKETLELMKSGRVEKGDVFSVSTISSIIGVKKTPELLPLTHNIPITNVDTKYEFEEDGIRVYVTVRSVSKTGVEMEALVGVASALLNIWDMVKKYEKDENGQYPTTEIREIKVVKKIKK</sequence>
</entry>
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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            <authorList>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        </source>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="111" mass="12647" checksum="CEC05A63C567CDB4" modified="2012-06-13" version="1">MEVSLKTGPVRMSGYALKLRRATNAALRKLYQEKKIEPKIANQMLTDLNKSLYDILINKYNIPKDAVINIELVLDISDSNLNLKDINISIYDKDDILSGNVTKELKQLLKL</sequence>
</entry>
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        <submittedName>
            <fullName evidence="3">5-oxoprolinase (ATP-hydrolyzing)</fullName>
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    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
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        <location>
            <begin position="195"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="656" mass="72293" checksum="843F47B5A5787477" modified="2012-06-13" version="1"> </sequence>
</entry>
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    <accession>H9ZZR1</accession>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="413" mass="45322" checksum="3771CF02FF3E567D" modified="2012-06-13" version="1">MSNWYLYKPVVRQYLQFAYSPEGRTLITTFISPRIFMGLAATPMFASSVSSALKKKRAFIVTDPYIKPMAFGVGRVLQSFGFNTTVWDKVVPEPPISTLKPCAQAMEQFDADLIVAVGGGSAIDTSKVAWALYERPDIDFKLINPMAPLGLRNKALFAAIPTTSGTGSEATSAAVITDESYSPPRKFSVVHPELVPDFAVLDPSFVVGLPPKLTLGTALDAFAHAVDSYLTHSSFEMTDFLAIGAIKLIMRWLPRVLSHSDDIEARLKIHEAATMAGLAFSNGGIALTHSLGHSLGKVFSIHHGFAVGVFIPYVIGFYAEVSDKYTELAKELGVNEEPLQKALVLKFLDFFKQVKAPLTLKDLGVDEAKLREKLDVLAEYAYEDICTPMSPRPISIEEVKELFLNALKGEYGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZT7</accession>
    <name>H9ZZT7_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Dehydrogenase, FixC domain protein</fullName>
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    <organism evidence="1 2">
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0253"/>
    <dbReference type="EnsemblBacteria" id="AFH42244">
        <property type="protein sequence ID" value="AFH42244"/>
        <property type="gene ID" value="FFONT_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0253"/>
    <dbReference type="eggNOG" id="arCOG00570">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066799_0_0_2"/>
    <dbReference type="OMA" id="KPCAWGV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="345" mass="38814" checksum="9ACCDC9031688FE6" modified="2012-06-13" version="1">MEFSRINIIGAGPAGASLAFFLSSLGYSNITVYESSKVLGSKPCGMAVPASIKDLIKLENEHIINEIKGYRLFIDEKLLHEDISGTHWGYIINKQKFLEDLVSDVEVKREHLKINLDELSKRKDELYVIAAGIYWNGSPKERLNAVEATVNVYNWNEPSIIQIWFDTKLMGYYWAFPHSEKKVNIGVGGFEDFFSLKARLIKFIKKIGSVEKMEPEKILGSQIVSTGIVDSILSPAENVFAIGEGVGSVLPLTGEGIRPSIQMAKIFSENISSKELFIQNFKSSALYKTSKIQRKILSILKQMPPFLRNKIMRSIPKDIMIKIGLGSYSENDVNKLKLILKTFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZU5</accession>
    <name>H9ZZU5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zn-dependent hydrolase of the metallo-beta-lactamase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0262"/>
    <dbReference type="EnsemblBacteria" id="AFH42252">
        <property type="protein sequence ID" value="AFH42252"/>
        <property type="gene ID" value="FFONT_0262"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0262"/>
    <dbReference type="eggNOG" id="arCOG00497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070010_3_0_2"/>
    <dbReference type="OMA" id="HFDHNAV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="227" mass="26387" checksum="7CF4F810951C94B1" modified="2012-06-13" version="1">MNNCLKIFYHGHSCFEVKTGSNSILFDPHPGESIGLKPIETKADIVLITHEHFDHNAKENVVKENTQVLSSYFGEKRLNANAEEIFVKGFKLPHDNQGGRKRGFVAAYLVKIRNFKLLHLGDLGSDISNELLNEVKKERIDFLFIPVGGYYTIGPQEAWEISKKINPEYIVPMHYWRKNMNLPISPLSDFLKFVNVKRTETTNPFEYCKDIEKIEREMEVLLFKEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZW2</accession>
    <name>H9ZZW2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydroorotate dehydrogenase</fullName>
            <shortName evidence="8">DHOD</shortName>
            <shortName evidence="8">DHODase</shortName>
            <shortName evidence="8">DHOdehase</shortName>
            <ecNumber evidence="8">1.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pyrD</name>
        <name evidence="10" type="ordered locus">FFONT_0279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of dihydroorotate to orotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(S)-dihydroorotate + A = AH2 + orotate</text>
            <dbReference type="Rhea" id="RHEA:18073"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="8">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.3.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0279"/>
    <dbReference type="EnsemblBacteria" id="AFH42269">
        <property type="protein sequence ID" value="AFH42269"/>
        <property type="gene ID" value="FFONT_0279"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0279"/>
    <dbReference type="eggNOG" id="arCOG00603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042042_0_0_2"/>
    <dbReference type="OMA" id="SCPHAKG"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 8" id="KW-0288">FMN</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHO_dh" evidence="9">
        <location>
            <begin position="7"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="73"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="193"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="244"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="308" mass="32776" checksum="28B6D1DB6B41EE24" modified="2012-06-13" version="1">MVILMTLNIELAGIILKNPLMNASGILGQNKEAIKRLYEYGFGAVVSKTITPMPRIGNKPPIILSLPNGGLINAVGLENPGKGTIKELVEEAKELNIPIIVSVGGTNEDEFSEVAKEAEISGANAIELNLSCPHTKGYGLEIGADPRNVFNVVKNVSSIIKIPVIAKLGLNDKIVEASGKALEAGAKALGLINTVKAIYIDVYTLKPVLSNIHGGLSGPPIHPIAVRVIYDVYREYRAEIIGSGGVKDWKDAAEFISAGAKAIQIGSALISNDDPKHTIKSILGGLENWLRFHNVTSLLELVGSAHRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZX9</accession>
    <name>H9ZZX9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">FFONT_0296</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0296"/>
    <dbReference type="EnsemblBacteria" id="AFH42286">
        <property type="protein sequence ID" value="AFH42286"/>
        <property type="gene ID" value="FFONT_0296"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0296"/>
    <dbReference type="eggNOG" id="arCOG01181">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018693_1_1_2"/>
    <dbReference type="OMA" id="GYTNFRE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO" evidence="12">
        <location>
            <begin position="66"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFH42286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="295" mass="34181" checksum="D64C8AC2528D885B" modified="2012-06-13" version="1">MITLKLGELYLKIPNEGFRILIAIESGLHKYEYVPISYIHQKARISSEKMNSILNLLSSLKLIRRQIGSIVGYKLTYLGLNMISLSAIVRKGLVTAIGDLTNVGKESEIYEAIGPGNLRLALKFHMVGRRSFKKTERLRSYVLEQRTSNWFDESKISAQREYKALDILSKYTKYVSEVVGYNRNLVVMKYVEGVELYKIKELKNPETVFLKILEVIDIAYNKVGIVHGDLSEYNIIIKLPDEIPVLIDWPQYFDKNHPNANSYLKRDIYNVCTFFNKKYNSQLNCEEFFIKILKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZZ7</accession>
    <name>H9ZZZ7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0314"/>
    <dbReference type="EnsemblBacteria" id="AFH42304">
        <property type="protein sequence ID" value="AFH42304"/>
        <property type="gene ID" value="FFONT_0314"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0314"/>
    <dbReference type="eggNOG" id="arCOG00751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_0_2"/>
    <dbReference type="OMA" id="TFVVIQF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="292"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="123"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="369" mass="40873" checksum="99FF879BF4051572" modified="2012-06-13" version="1">MASLSRTITLQIISNIAALIIIVAVISALLVFYSQTTLQGIVVEMVQDFARQLAKNPTIPPDQRQQLVNMYQQSLMVRFGLVGNPLTKVYHMMINIFMLNLGNSRQSYMAGTTSISGQVIFALKNTVILFLTATLISTLLGLGLGMYAARRPHGIIDSLVSFFAILSSSLPMWWVGMLMLLAFAFNLHWFPTQSLPVYFAIQQLHAQYASGAIGFFTYVFDYIQTWLYYMTLPLITVVLVSIGGWAYIVRNVVIGKMAEDFVMTARAKGVPERRVLFGHVLRAASPPIVTTAVLNIIVSLGGAIITETVFGWPGMGLLFWIAIENSEPMLIAGNVYITVLLFIIAVIILNILYVFLDPRVKTSGGQQIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZZ8</accession>
    <name>H9ZZZ8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Oligopeptide ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0315</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0315"/>
    <dbReference type="EnsemblBacteria" id="AFH42305">
        <property type="protein sequence ID" value="AFH42305"/>
        <property type="gene ID" value="FFONT_0315"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0315"/>
    <dbReference type="eggNOG" id="arCOG00749">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_10_0_2"/>
    <dbReference type="OMA" id="IKEQTYV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="296"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="500" mass="55944" checksum="02C331EC58965429" modified="2012-06-13" version="1">MDNKFSKGGIILSKRFSTKGLKRFFGELKRSKVGIAGFTLFLIFLLLALLFPYIGNMNDIKNWDNLQYWQDNPKAVPPCWATSNQFSTVRVVGEEKSDNLIVRTGEFENFTYKEYSFMYELKNVPPNEIIFSFNINYNSPVYVMLVLIRPDNKTLYLTGNPISGQYTSITNLFGVSPNSYTGSIRLPVSTYINNMVTDNTYILPWLQENNITLPIQDVYRLPSLAFNAIHEVLSPNMLETISPTYLTGTYNWTIMFYSTGNFTVNVKEITALGGCYGIFGTDNVGRDLFMGLIYGIRWALIIGFSVSVISVLFGGLYGVIGGYLGGKTDEILLRVAQIFYSIPILPILILLAIIFRPSIWNVISMLIIFGWPSTAIVTRSMALQIKEETYVEAAKALGASSSRILLRYIFPQVLPYLFASMALSVPGAILTEASLSFLGLGDPSIVTWGRILNEAEIAGATINGYWWWVIPPGLMITLIGLTFILIGQALDTILNPKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A003</accession>
    <name>I0A003_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0320"/>
    <dbReference type="EnsemblBacteria" id="AFH42310">
        <property type="protein sequence ID" value="AFH42310"/>
        <property type="gene ID" value="FFONT_0320"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0320"/>
    <dbReference type="eggNOG" id="arCOG01278">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_2"/>
    <dbReference type="OMA" id="DGGCIAN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="20"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="386" mass="42500" checksum="B22B5643C686165B" modified="2012-06-13" version="1">MSAFITGFGLTKISRDFYSTIEDMVYNAVKKMLDQFGNLSFVDTVIVANAFGYSMQRQNMFSSLISEELGIKGARTFNVEAGQISGHSGLILADSLIKSGYSKHVLLIGFEKMSDYNSEVYNSLISQLTNIEYEGIYGSTLASNFGIIARYYQEKYGLKEEEFASWPILMHENASETYHAQLRFKISTKQVLESEAVSLPIRMLHSPPISDGAAALLISREDRELVGKEKRVVEIRKGCISSGTFELSLRESLLFFDSLEYARQCYGINAFAEDIAKTEYISMSDDYTITAAVIAETIGLSKKGQFFADIYSGKFRIGDKQMINITGGTKARGYPIGALGVYEAAEISAMMSGEKIRSNQIDLNDAIMIGIGGAGSSSAILHLTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A010</accession>
    <name>I0A010_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0327</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0327"/>
    <dbReference type="EnsemblBacteria" id="AFH42317">
        <property type="protein sequence ID" value="AFH42317"/>
        <property type="gene ID" value="FFONT_0327"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0327"/>
    <dbReference type="eggNOG" id="arCOG01608">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_5_0_2"/>
    <dbReference type="OMA" id="MKSNYIS"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="4">
        <location>
            <begin position="22"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="5">
        <location>
            <begin position="266"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="404" mass="45391" checksum="C7B281DDD5762076" modified="2012-06-13" version="1">MSSKNINKKVLSGNHSVAYGVKLSKASVISAYPITPQTAIIEKLSEFVERGELKARIIKVESEHSALAATFGAALGGARAFTATSSHGLLYMHEWLHWVSRSRIPVVMAIVTRTIGLPWNIWPDHSDYMDQRDTGWIMTFGMDNQEVLDLTLQAFKLSEDPDIYLPVIVGLEGFVLGGTYMPVILPDEREAEDFVGERAQPYTIDPKNPIAIGNMTLPEGTEEMFMDMQKSMMNVYKKAKEIDSEYGKIFGRSYGGLTACYKCEDAKYMMVTMGAWSGDAIEAVNVLRSEGYPVGLLRVRYFRPMPTEDYKKYLFNSKMTIVFDRSISYGSTGSIYQDVISSLHLASSKINVVHNVIAGIGGVDMTLKDFYEIFRSFLKQYESGDESNKVVWYHKGVMNNFSFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A061</accession>
    <name>I0A061_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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    </dbReference>
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        <property type="term" value="F:phosphoglucosamine mutase activity"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
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        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
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    </dbReference>
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        <property type="entry name" value="A-D-PHexomutase_C"/>
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        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
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        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024086">
        <property type="entry name" value="GlmM_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03990">
        <property type="entry name" value="Arch_GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="8">
        <location>
            <begin position="3"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="9">
        <location>
            <begin position="154"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="10">
        <location>
            <begin position="260"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="452" mass="50702" checksum="B6E3D3AB359543AD" modified="2012-06-13" version="1">MGKIFGTDGIRLKVKNELQAEFLVKISQAICEEFGERSVFLLGRDVRYGGELIRHAIISGFLTSGCRVYDAGLITTPALQYVIKNEGFFDGGVMITASHNPPEYNGIKVIDSDGIEIPREKENEIEKIYLENRISGKISSEEKFFIPKYPDPLDKYLEGILDNVDDEIIKRRNFKVVVDGANSVGSLVIPKLVKLLGGKPISLNSHLDPDFSGRLPEPTPETLFDTSNVVKAVNADLGIAVDGDADRSIFLDEFGNVLWGDKTAVILSIYLSEKNPELPKKVYTGISSSYFIEELLKKRGIDVIWMKVGSVDIARKLKKEGGLLGFEENGGIMYPKHQYVRDAGMALALMLEVMSAERKKISELYSIYPKTYTIKTKYSIDISKAKEIIEKIKNCYRSYPMIDIDGVKVLQEDSWFLVRPSGTEPVLRVMVESKIQNKEKLILKELEKIILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0A4</accession>
    <name>I0A0A4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4Fe-4S ferredoxin, iron-sulfur binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0421"/>
    <dbReference type="EnsemblBacteria" id="AFH42411">
        <property type="protein sequence ID" value="AFH42411"/>
        <property type="gene ID" value="FFONT_0421"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0421"/>
    <dbReference type="eggNOG" id="arCOG00961">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="QFCGFCE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="109" mass="12185" checksum="68D25A3F6B9B3737" modified="2012-06-13" version="1">MEDAQSKDEEIVNEKIKVVLDDALSCAFCGNCEWVCPTLKIKKNRIYGPRGRITAILNFVRENVLTDGAVDAIFTCLQCGACVTQCPANIRIDEDVRTVKSYLINKNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0C4</accession>
    <name>I0A0C4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP-dependent dephospho-CoA kinase</fullName>
            <ecNumber evidence="3">2.7.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Dephospho-coenzyme A kinase</fullName>
            <shortName evidence="3">DPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0441</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3'-dephospho-CoA + GTP = CoA + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61156"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP-dependent DPCK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0441"/>
    <dbReference type="EnsemblBacteria" id="AFH42431">
        <property type="protein sequence ID" value="AFH42431"/>
        <property type="gene ID" value="FFONT_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0441"/>
    <dbReference type="eggNOG" id="arCOG04076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120795_1_0_2"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00590">
        <property type="entry name" value="Dephospho_CoA_kinase_GTP_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007164">
        <property type="entry name" value="GTP-dep_dephospho-CoA_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40732">
        <property type="entry name" value="PTHR40732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04019">
        <property type="entry name" value="DUF359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1 3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="174" mass="20003" checksum="EAF7F7EF86456B75" modified="2012-06-13" version="1">MNDKLKKVLSEPFGPIYSGSSFENLIKTTHNKFRYITIGDYVTEKYIEIAEKSPVLSFVDMQTKRERYDISKIKSYYTDIIEIYNKQGTISKETINEELSEVLINYIQGISSLVIVRGEEDLLSLYVPLLIPMNSSGRVIYGQPGMGAVVFDVNEKTKREISNILQDFYIEFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0D4</accession>
    <name>I0A0D4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">50S ribosomal protein L7Ae</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ribosomal protein L8e</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rpl7ae</name>
        <name evidence="10" type="ordered locus">FFONT_0451</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the 50S ribosomal subunit. Probably part of the RNase P complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0451"/>
    <dbReference type="EnsemblBacteria" id="AFH42441">
        <property type="protein sequence ID" value="AFH42441"/>
        <property type="gene ID" value="FFONT_0451"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0451"/>
    <dbReference type="eggNOG" id="arCOG01751">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084513_4_0_2"/>
    <dbReference type="OMA" id="KPFYVRF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00326">
        <property type="entry name" value="Ribosomal_L7Ae_Arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_L7Ae/L8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022481">
        <property type="entry name" value="Ribosomal_L7Ae_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_L7Ae_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000948">
        <property type="entry name" value="Ribosomal_L7Ae_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00884">
        <property type="entry name" value="RIBOSOMALHS6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03677">
        <property type="entry name" value="eL8_ribo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 8 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="9">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="126" mass="13667" checksum="705C438CD3D0F0B8" modified="2012-06-13" version="1">MSKQFYVTFNVPPEIADETYKLLEKVKQSGKIKKGTNETTKAVERGVAKLVVIAEDVDPPEVVAHLPLLCDEKKIPYTYVPSKKKLGESVGIDVQAAAVAIIDPGDAKEGLNSLISKISELRSKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0D8</accession>
    <name>I0A0D8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Isopentenyl-diphosphate delta-isomerase</fullName>
            <shortName evidence="7">IPP isomerase</shortName>
            <ecNumber evidence="7">5.3.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl diphosphate:dimethylallyl diphosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Isopentenyl pyrophosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Type 2 isopentenyl diphosphate isomerase</fullName>
            <shortName evidence="7">IDI-2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fni</name>
        <name evidence="9" type="ordered locus">FFONT_0455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homooctamer. Dimer of tetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the IPP isomerase type 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="7"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0455"/>
    <dbReference type="EnsemblBacteria" id="AFH42445">
        <property type="protein sequence ID" value="AFH42445"/>
        <property type="gene ID" value="FFONT_0455"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0455"/>
    <dbReference type="eggNOG" id="arCOG00613">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065515_1_0_2"/>
    <dbReference type="OMA" id="WDWGIPT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02811">
        <property type="entry name" value="IDI-2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00354">
        <property type="entry name" value="Idi_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011179">
        <property type="entry name" value="IPdP_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43665">
        <property type="entry name" value="PTHR43665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003314">
        <property type="entry name" value="IPP_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02151">
        <property type="entry name" value="IPP_isom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_dh" evidence="8">
        <location>
            <begin position="171"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="93"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="271"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="292"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="367" mass="40402" checksum="FB7BD24994026F9B" modified="2012-06-13" version="1">MNIANRKLDHIIIALSKKIETSDTLLKNIQLIHQALPELSFDSINTTVEFLGKKLSAPLMFTGITGGHVYAGDINRVLAKVAEENKIAIEVGSQRAALVDPSVSWTYRVVREEAISVPVIANLGAQQLGDKPVEIAEKAIKMIDADAIAIHLNVAQELFQLEGDRDFRNILKNIEILRNELSVPIIVKEIGYGISKEVASALVKAGVKYIDVAGAGGTSWIKVEILRRKLRGEKVDLPGIYEFYNWGIPTALSIIETRSVSSEIKIIASGGIRNGVEVAKSIAIGADIAGFALPALKEAARSKECLDRYVRNIIMELKIAMLLTSAKDVEELKNVPIVFDEKITNWLSQRGIDPIKFLENRKIKKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0E4</accession>
    <name>I0A0E4_FERFK</name>
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        <recommendedName>
            <fullName evidence="2 6">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
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        <name evidence="7" type="ordered locus">FFONT_0461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0461"/>
    <dbReference type="EnsemblBacteria" id="AFH42451">
        <property type="protein sequence ID" value="AFH42451"/>
        <property type="gene ID" value="FFONT_0461"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0461"/>
    <dbReference type="eggNOG" id="arCOG04243">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_4_0_2"/>
    <dbReference type="OMA" id="FMGQAEA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019958">
        <property type="entry name" value="Ribosomal_S9_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="uS9_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="131" mass="15086" checksum="C46E7017D48D679C" modified="2012-06-13" version="1">MVLSVGKRKSAIAKVVIKPGKGRVLVNEMPIELHPVELFRNKIVEVLKLLGKDHREQVDIIASVNGGGFMAQADATRTAIARGLVKYFESERLKTIFQEYDRVLLAGDPRRTEPEKYMRYSARRRWQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0F5</accession>
    <name>I0A0F5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0472"/>
    <dbReference type="EnsemblBacteria" id="AFH42462">
        <property type="protein sequence ID" value="AFH42462"/>
        <property type="gene ID" value="FFONT_0472"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0472"/>
    <dbReference type="eggNOG" id="arCOG03694">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="FLWWYLF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021741">
        <property type="entry name" value="DUF3311"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11755">
        <property type="entry name" value="DUF3311"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="73" mass="8985" checksum="53116E750E562B24" modified="2012-06-13" version="1">MERGKLSKGKHFIKILLLMLIPWTALVFTAPIYNRKEPYLGGWPFLYWYLFSWIFIQPVLTFIVFKFIDRERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0G3</accession>
    <name>I0A0G3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydroxyacylglutathione hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0480"/>
    <dbReference type="EnsemblBacteria" id="AFH42470">
        <property type="protein sequence ID" value="AFH42470"/>
        <property type="gene ID" value="FFONT_0480"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0480"/>
    <dbReference type="eggNOG" id="arCOG00504">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_2_2"/>
    <dbReference type="OMA" id="GAWGTNC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="23"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="222" mass="25155" checksum="24097630AB9911BB" modified="2012-06-13" version="1">MQAIKKFSIGNLAIYAIKHGVLRTNTYIIFSKDPKKALMIDPGESSNVIVDFLKNRDLNSIWVIGTHGHFDHVCGVDEIKSAYNAKFFMSSEDLFLKEHNKKVLKRFNLNEKDCPLDPDIDLKDLEKIEFDDQEIEVLKTPGHTPGSILLYLREVDLAFSGDTIFAGSIGRTDFFGGNEEEMKKSIKLILERVNADALVLPGHGIEFRLAKYIDFFNSIIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0G8</accession>
    <name>I0A0G8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Polysacc_synt_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0485</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42475">
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        <property type="gene ID" value="FFONT_0485"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="69"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="183"/>
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            <end position="284"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="318"/>
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        <location>
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            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="494" mass="54265" checksum="5BAED609DC005C44" modified="2012-06-13" version="1">MSRESHVGKVISSGFWLYLSTIISNLQGFFYWLIISRIAGGSVVGTVSAIVGLSSLISGLISLGITTGLSRYTGLCIGIKKSNECASEYLWTSVYFSLLIYIIGGILVFIYSKFFGGAGSYSTEELTIAALLVFVGFAGSFTSFLQSLLLTKYIFISVVAAAIFKFTLGVLLVYFGYGWVGAALGYFVSTVVQFVINSYHSLKITGFKIYFSKDKLKELLRAGIPSWLPGVISTIGQWFGVILLYGTIGSLETGSYFIASQLANVVLNISNILNGLLLPVLSGLSDGRKRVGSRVFRISLALMLPVSFYIMVYPTLLLDIFGKELSSGSIPLVILLFGSIPVAFSGFVSSLVYAYGDYLTILKSGLITNVPRVILYFILVPKMSGIGAAISFTTGSYLGALYLLYIAYKLQVQFKKKEIAILISVPLIFSVLLFFVRLSWYLGMLIMASSYLIYIKEKIVTKEDLKEISRALLGEERTSLLYQKMRPILEPLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0H0</accession>
    <name>I0A0H0_FERFK</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccaceae</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42477">
        <property type="protein sequence ID" value="AFH42477"/>
        <property type="gene ID" value="FFONT_0487"/>
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    <dbReference type="Proteomes" id="UP000007391">
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        <property type="term" value="F:catalytic activity"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <end position="304"/>
        </location>
    </feature>
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            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="317" mass="36438" checksum="833F8B6EE347759A" modified="2012-06-13" version="1">MNKLKEVPAIKLIPTWAFKDVIGDEMGRTRNLEYINTIKERLKKFGLEFALFHEVPLTSIAISSDSDCIQTFSPTTGEEDLSLIATFTGKRIIFSNPYYFNGNSIVFKEDELKEEGCMSYASNPNIPLGFFMNEEKIVEIAKKLNGLVVVDSTYDFLFDNDLNQIIINEKLARLLDQFREAEVLVIKKLHKIFGLYENPLILLYTNSHRVFETLSLITNNEERLCIDCLSLYGRILSDNELLNRINIIKEKLEEKKKELINVIRSNGGIVFESLAPYFVASSLNEKVLKELSKKAELEKAGEYLFLGEKYYVIFPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0H6</accession>
    <name>I0A0H6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14e</name>
        <name evidence="4" type="ordered locus">FFONT_0493</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH42483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42483">
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        <property type="gene ID" value="FFONT_0493"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0493"/>
    <dbReference type="eggNOG" id="arCOG04167">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_183474_0_0_2"/>
    <dbReference type="OMA" id="RRCNIKH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="KOW_RPL14"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023651">
        <property type="entry name" value="Ribosomal_L14e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_protein_L14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041985">
        <property type="entry name" value="RPL14_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="98" mass="10825" checksum="DFDD5B190A6F2464" modified="2012-06-13" version="1">MPAIEIGRVCVKTYGREAGRKCVIIDIVDENFVLVTGPKNISGVRRRKVNINHIEVLDAKVPINKGASDEEVEKAINAAGLTQFMRERIKISKLPAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0H9</accession>
    <name>I0A0H9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Adenylate kinase</fullName>
            <shortName evidence="8">AK</shortName>
            <ecNumber evidence="3 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">adkA</name>
        <name evidence="10" type="ordered locus">FFONT_0496</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the archaeal adenylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="3 8"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0496"/>
    <dbReference type="EnsemblBacteria" id="AFH42486">
        <property type="protein sequence ID" value="AFH42486"/>
        <property type="gene ID" value="FFONT_0496"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0496"/>
    <dbReference type="eggNOG" id="arCOG01039">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119371_0_0_2"/>
    <dbReference type="OMA" id="HRDEMRK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00234">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023477">
        <property type="entry name" value="Adenylate_kinase_AdkA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="6"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="14"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="206" mass="22921" checksum="AA4530F834B1C378" modified="2012-06-13" version="1">MVTRNAFKTIIVTGVPGVGKTTVLNELKLEASKKSIYIKVLNFGDYMFFEAQKSKLVNNRDELRKLPHRVQLQLQEVAARKIIDEANVSLKANDVLIIDTHAVVKTKTGFWPGLPQHVITQLYPDSIVLIEAEPREIIDRQAKDTTRERKDISGKGIQDLVELMNMARIAAMSSATLVGASVFIVENPQGKANEAAQKILELAMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0I1</accession>
    <name>I0A0I1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl15</name>
        <name evidence="8" type="ordered locus">FFONT_0498</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0498"/>
    <dbReference type="EnsemblBacteria" id="AFH42488">
        <property type="protein sequence ID" value="AFH42488"/>
        <property type="gene ID" value="FFONT_0498"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0498"/>
    <dbReference type="eggNOG" id="arCOG00779">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109163_0_0_2"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.990.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027386">
        <property type="entry name" value="Rbsml_prot_L15/27a_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_L15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="7">
        <location>
            <begin position="31"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="148" mass="16616" checksum="A215637276EDB824" modified="2012-06-13" version="1">MVVRFRRKVRKLRGRTRTMGWGRIGQHRKTGSKGGRGAAGMLKHKESWMRKYAPGWIGKHGFTSPYEKKEKVYEINLLQLDELVEELASKGVLKEDSGKPIIELDKLGFTKLLGTGRISRPIKVVVKEASEKAIEKVKSVGGEVITEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0I7</accession>
    <name>I0A0I7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl6</name>
        <name evidence="5" type="ordered locus">FFONT_0504</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0504"/>
    <dbReference type="EnsemblBacteria" id="AFH42494">
        <property type="protein sequence ID" value="AFH42494"/>
        <property type="gene ID" value="FFONT_0504"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0504"/>
    <dbReference type="eggNOG" id="arCOG04090">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_0_0_2"/>
    <dbReference type="OMA" id="VFQDGIY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="16"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L6" evidence="4">
        <location>
            <begin position="112"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="185" mass="20669" checksum="A060BB51F5C32C88" modified="2012-06-13" version="1">MESLVKSVHVVEEVEIPEGVKISIEGMKVVVEGPKGKIEKDFSHTRNVAISLSDGKVVVESYFARREQKALVGTIAAHIRNMITGVQKGYRYKLKIISSHFPISLEQKGDVILVKNFLGEKSPRKARIMPGVKVKIEKEDVIVEGLDIEAVGQTAANLEQATKVKEYDRRVFMDGIYIYEKGEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0I9</accession>
    <name>I0A0I9_FERFK</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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    </gene>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds 16S rRNA, required for the assembly of 30S particles.</text>
    </comment>
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            <name>Zn(2+)</name>
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        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42496">
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        <property type="gene ID" value="FFONT_0506"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <feature type="binding site" evidence="3">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
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        <location>
            <position position="22"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="37"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="40"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="54" mass="6605" checksum="B0C7A8F022986566" modified="2012-06-13" version="1">MTKYVQPRERKYGKAVIKCQRCGSRKGVIRRYNLYLCRQCFRELAYEMGFKKYS</sequence>
</entry>
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    <accession>I0A0Q2</accession>
    <name>I0A0Q2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0569"/>
    <dbReference type="EnsemblBacteria" id="AFH42559">
        <property type="protein sequence ID" value="AFH42559"/>
        <property type="gene ID" value="FFONT_0569"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0569"/>
    <dbReference type="HOGENOM" id="CLU_2783869_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="68" mass="8025" checksum="572F6E6916237A8E" modified="2012-06-13" version="1">MGPVIGRTQNAVEEISNILKLSEKHILYSGVQVLYKFIDQYYPLISIPLHPDPDWFYMWLRGFREQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Q9</accession>
    <name>I0A0Q9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Na_H_Exchanger domain containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ordered locus">FFONT_0576</name>
    </gene>
    <organism evidence="6 7">
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0576"/>
    <dbReference type="EnsemblBacteria" id="AFH42566">
        <property type="protein sequence ID" value="AFH42566"/>
        <property type="gene ID" value="FFONT_0576"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0576"/>
    <dbReference type="eggNOG" id="arCOG01955">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_476202_0_0_2"/>
    <dbReference type="OMA" id="KWSAKER"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006812">
        <property type="term" value="P:cation transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2020-12-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A101</accession>
    <name>I0A101_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">tRNA wyosine derivatives biosynthesis protein Taw3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">taw3</name>
        <name evidence="7" type="ordered locus">FFONT_0669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TYW3 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.282" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0669"/>
    <dbReference type="EnsemblBacteria" id="AFH42658">
        <property type="protein sequence ID" value="AFH42658"/>
        <property type="gene ID" value="FFONT_0669"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0669"/>
    <dbReference type="eggNOG" id="arCOG04156">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047426_2_1_2"/>
    <dbReference type="OMA" id="GKWHHYA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00266">
        <property type="entry name" value="TYW3_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022908">
        <property type="entry name" value="Taw3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSF111278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TYW3" evidence="6">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="191" mass="22069" checksum="872C6DBF0E3F63CE" modified="2012-06-13" version="1">MADPWERRKSAFLERIKRDREIGYLDPGIEETLDLINSREKSYTTSSCSGRISAVDSEFPWKRDDEHPIFKKHAPITEEELEDFLKVEPKDIIWLIVSGPILHICCRDIEEAREMLRVARQAGFKHSGIMSISEDCFMVELISGTQLFLPLKSRTKLFIEAGSMNDILFLVNESLSEGRNRLKRLNEALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A104</accession>
    <name>I0A104_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon monoxide dehydrogenase small chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0673"/>
    <dbReference type="EnsemblBacteria" id="AFH42661">
        <property type="protein sequence ID" value="AFH42661"/>
        <property type="gene ID" value="FFONT_0673"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0673"/>
    <dbReference type="eggNOG" id="arCOG01925">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_1_2"/>
    <dbReference type="OMA" id="YPRIHKA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="157" mass="17342" checksum="217CAA5DDF73FBF1" modified="2012-06-13" version="1">MARTITLKLNGRMRTVEVEDNETLLEVLRDRLGEMSVKAACWKGECGLCTVLFNGRPVKSCMVLGVEADGGEVVTAAGISRDGELAPVQKAFIEHGAFQCGFCTPAFVVATHYFLQKNPNPTREEVKEFLSGILCRCTGYKQIIDAVMDAAKYYRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A140</accession>
    <name>I0A140_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">p-loop ATPase/GTPase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0709"/>
    <dbReference type="EnsemblBacteria" id="AFH42697">
        <property type="protein sequence ID" value="AFH42697"/>
        <property type="gene ID" value="FFONT_0709"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0709"/>
    <dbReference type="eggNOG" id="arCOG04328">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084678_0_0_2"/>
    <dbReference type="OMA" id="NGWYQYE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="288" mass="32628" checksum="5A2E3F6438753882" modified="2012-06-13" version="1">MKKILIAGLLPYDSGKTTFSISLILHLRDMGIKAHPFKPVSSHNIFTQSSSFSESINMKLLAGGDALQYKHAFDFDIDMLKATNPLDLLLSPTDPSIYLKNSRLPSYYEDQENLFKLVSLMRITECKTMSAKHYFIRDNTDLFPPSFRKNIEHLSSITEALPISLDEALKILRSRELEDNFDICLERIGKGFNTIIVESFSDSLFPYFSSLKDSSMIIVVSPGRAFAYFDEEKVKKIKELKGIPKGSPRTMYLISRYEPDLDEALDLKDPLSSSSKLSSEISKRIDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A147</accession>
    <name>I0A147_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42704">
        <property type="protein sequence ID" value="AFH42704"/>
        <property type="gene ID" value="FFONT_0716"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0716"/>
    <dbReference type="eggNOG" id="arCOG04321">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064235_0_0_2"/>
    <dbReference type="OMA" id="SISPWME"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007841">
        <property type="entry name" value="UPF0210"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37560">
        <property type="entry name" value="PTHR37560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05167">
        <property type="entry name" value="DUF711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="355" mass="40375" checksum="77549AF8C98E6B75" modified="2012-06-13" version="1">MIDLRIRALTLHLNLSRERKEEEALKNAVSDLYSAKEKIEKEIGLEVWSLRVSIPINWELSDSSMDVLKKEKEIKAVIYTSTSDLLNEEKVFRAVSRGYNAGIFLRSERDLSKILDLIYNLSLKDPAFSTRFAVEMSGLGITTPYFPLSIHDSSVKEDYFSIALLYPKDVEGGEDLRAVELAIEKAYRSLSKFIREGIGKKKLRGIDYSLSPWMEESVGRALEKIGRCKLSDLKCMKTVYEVNSILSDFASKHEGLGFNEIMLPLGEDSYLMSLALNGELTIKDLLLLSYVCVAGMDMIPVRGKKEQFEDLLRDIYAVARVKRRPYGVRLIYINEDFKDKEVNLGDFGKAPILNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A177</accession>
    <name>I0A177_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ordered locus">FFONT_0746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0746"/>
    <dbReference type="EnsemblBacteria" id="AFH42734">
        <property type="protein sequence ID" value="AFH42734"/>
        <property type="gene ID" value="FFONT_0746"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0746"/>
    <dbReference type="eggNOG" id="arCOG01703">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074522_0_0_2"/>
    <dbReference type="OMA" id="GATHIQD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="2"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="94"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="196" mass="21641" checksum="32094BC8CB1AF562" modified="2012-06-13" version="1">MKRIVVALTGASGIIYGKKLIEVLVEKSYNMEIIYTEHANLVSKLEEGVSLEEFLVGISKKHSDKIKIYKEKDFMSPLASSSNIGDAMVIVPCSVKTLSQISYGISDNLVVRAALAFLRMKKKLVVVPRETPLGLIELNAMVELAKAGAIILPAMPAFYHKPKGIDDIVNFIVGKILDALGIENDLYERWGKENSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A189</accession>
    <name>I0A189_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative permease (Drug/metabolite transporter superfamily)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0758</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0758"/>
    <dbReference type="EnsemblBacteria" id="AFH42746">
        <property type="protein sequence ID" value="AFH42746"/>
        <property type="gene ID" value="FFONT_0758"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0758"/>
    <dbReference type="eggNOG" id="arCOG00271">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_978689_0_0_2"/>
    <dbReference type="OMA" id="MTLYQLA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="138"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="291" mass="32784" checksum="E6335CBF6046075F" modified="2012-06-13" version="1">MKEEGKALVFFLIYVIGSVPLNFFVKDLLEYFSIGFSLFIRFIIMLLFTILFSKKIILNKNIAVLSFFVFLSTTLWLYSLIYLSPADSLVLSYSMPLIASLIGRRILNEKSGEIYGVLVAFLGYIAYSYNLMKGFTLYGTVLSFINAFAWAYYSVLYRKLRTFDVFVLNSSVFLICSLFSLAVLPLYQPIIKAGADDNVFADVIWFATIGGAIQFLSWNRVLSIWSASKATVLSYIVPILTFIIQCFSNKESPSLLQVIGIALITIGVILTFRNELKNHSNSSLSDESISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A194</accession>
    <name>I0A194_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Prenyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FFONT_0763</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <property type="protein sequence ID" value="AFH42784"/>
        <property type="gene ID" value="FFONT_0796"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0796"/>
    <dbReference type="eggNOG" id="arCOG00367">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_714961_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018977">
        <property type="entry name" value="NurA_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09376">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00933">
        <property type="entry name" value="NurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NurA" evidence="1">
        <location>
            <begin position="55"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="386" mass="44233" checksum="667A0D9C7B90870A" modified="2012-06-13" version="1">MAFHEDLFEAAIRKRDLIISKLKKFIDMYDKDIIKQFNEVQDFSNTKREDLYRPTKIAGIDGGSLPKSFLGFDLYFIKTYAIRLHLNEEKNEYVRGSTYKIADIDMLIPPGSLQDRITVYRQVTELRAILDSLKNNYFTLEDGSAESLISRPTHIRPRILNGLSEYSCEDIGKIVNKSFNDEFTSMGIKSLIEEIYEKEKKSDLNELAFKLELGEKFYYISEILKEITKGKELFFVTKTGRSNDFFNSSLSDQYIISMKTKVAGFITRSPLPLSKVVEESKTSFCGVSDLMDEVYLLTGYARLENFGPVLKVELLLPKFKAESISDPNKFYYEKLLQISSISVSGYPYVLSLAHQEAHIYLNTVEVIVDALGLGEEPTGREEIEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1I1</accession>
    <name>I0A1I1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hexulose-6-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. PHI subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0850"/>
    <dbReference type="EnsemblBacteria" id="AFH42838">
        <property type="protein sequence ID" value="AFH42838"/>
        <property type="gene ID" value="FFONT_0850"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0850"/>
    <dbReference type="eggNOG" id="arCOG00068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094236_1_0_2"/>
    <dbReference type="OMA" id="KTIQPMG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05005">
        <property type="entry name" value="SIS_PHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017552">
        <property type="entry name" value="PHI/rmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43443">
        <property type="entry name" value="PTHR43443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03127">
        <property type="entry name" value="RuMP_HxlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SIS" evidence="2">
        <location>
            <begin position="34"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="200" mass="21896" checksum="DC84C148AECF5F72" modified="2012-06-13" version="1">MEYEYEAMKEIATFINKSIDELKFDEVDRVVKRLVDAYNSKSKILVMGAGRSGLVGRAFAMRLMHLGFNSYVLGDTITPSISKGDIVVAISGSGRTELIITAARAAKKTGAEIIAVTSFLNSPLGEISDLVLEVPGRTKLADEHDYFARQILGIHEPLAPLGTLFEDTALVVLDGIVVGLMYRLGKKEEDLKQKHANIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1K0</accession>
    <name>I0A1K0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myo-inositol-1-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0869"/>
    <dbReference type="EnsemblBacteria" id="AFH42857">
        <property type="protein sequence ID" value="AFH42857"/>
        <property type="gene ID" value="FFONT_0869"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0869"/>
    <dbReference type="eggNOG" id="arCOG04213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050011_0_0_2"/>
    <dbReference type="OMA" id="GTKEWAD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inos-1-P_synth" evidence="2">
        <location>
            <begin position="193"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="368" mass="40420" checksum="2CF1E0492D68B5FF" modified="2012-06-13" version="1">MGKIKVGLIGIGNCASAIVQGVLLSKKDPNKTKEILFTDIGGYKIEDIDFTLAIDVDVRKIGKDLGDAIFEGPNLFPKIVDDTKTGVKVIAGPVLDGVADHMRNIFMPHNKEVTMEEIVSAIKSSGTEVLVNMLPVGSEEATRFYAEAAIKAGVAFINGMPVFIASDPKGEWQEKFKKAGLPVLGDDVKGQFGATILHSSLTALMRERGLRINETYQLNIGGNTDFLNMKEEERLRSKRESKTSAVLNTLTNPKEILEKNRIRIGPSDWVPFLGNTKIAYIYVRATSFLGFPVELDVKLKVDDKSQYAAAMIDVIRLAKLALDNGLSGAIHEASAYYMKHPPKPVSSPYEARSLLEEFIRKYGKKSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1K4</accession>
    <name>I0A1K4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0873</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA damage repair.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a predicted C4 metal binding domain at the N-terminus, which could be a zinc finger DNA binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nre family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0873"/>
    <dbReference type="EnsemblBacteria" id="AFH42861">
        <property type="protein sequence ID" value="AFH42861"/>
        <property type="gene ID" value="FFONT_0873"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0873"/>
    <dbReference type="eggNOG" id="arCOG04269">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039703_0_0_2"/>
    <dbReference type="OMA" id="EIYPGFN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02096">
        <property type="entry name" value="Nre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033167">
        <property type="entry name" value="Nre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006979">
        <property type="entry name" value="Nre_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006978">
        <property type="entry name" value="Nre_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38136">
        <property type="entry name" value="PTHR38136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04895">
        <property type="entry name" value="Nre_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04894">
        <property type="entry name" value="Nre_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nre_N" evidence="2">
        <location>
            <begin position="17"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Nre_C" evidence="3">
        <location>
            <begin position="296"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="407" mass="46971" checksum="5B862B991015AE71" modified="2012-06-13" version="1">MKIDTRLCVLCRGRGYCGLAYCPIIARNTALTKLKGLTEKKEIYGSSPPSVFVGRIGYPKVRIGPSSPPLSGDTQIYELPESWLKLRIEDILDYRYSLITGYNYASVNQVNEKFVNEVRDIAMSIKPVEIEMKLIKPPVPIVIFDEEQPPFGPSSPIERFKIVNNPSIPKIIDSLYYDEIKAKDAIIYLYERNFPVSYISKVMSIGTFGEREKRRLVPTRWSITAVDSTISEELLKKVKGFQEISEIEVYELKIHDNLFISILFPRSWSFEWMEAWWPGSTWNPQNGDVEIEGDYEYYRGRKNYPSIGGCYYSARLATAELLLNKKRQATAVLLREIYPGFNVPIGVWFVRESIREMYKRGPVMKTYDINEVVSFLNKETKLGSAKWIASSKIIQLIMTEKKITEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1K7</accession>
    <name>I0A1K7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lysine-specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0876"/>
    <dbReference type="EnsemblBacteria" id="AFH42864">
        <property type="protein sequence ID" value="AFH42864"/>
        <property type="gene ID" value="FFONT_0876"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0876"/>
    <dbReference type="eggNOG" id="arCOG00009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007946_16_0_2"/>
    <dbReference type="OMA" id="FAGFINF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
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            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
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        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
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        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="483"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="546" mass="60395" checksum="5943CC9161353F3B" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1M6</accession>
    <name>I0A1M6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dCTP deaminase</fullName>
            <ecNumber evidence="2">3.5.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Deoxycytidine triphosphate deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dcd</name>
        <name evidence="4" type="ordered locus">FFONT_0895</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the deamination of dCTP to dUTP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>dCTP + H(+) + H2O = dUTP + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="EC" id="3.5.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dCTP deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.13" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0895"/>
    <dbReference type="EnsemblBacteria" id="AFH42883">
        <property type="protein sequence ID" value="AFH42883"/>
        <property type="gene ID" value="FFONT_0895"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0895"/>
    <dbReference type="eggNOG" id="arCOG04048">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087476_3_0_2"/>
    <dbReference type="OMA" id="FENHRYP"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00665"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008829">
        <property type="term" value="F:dCTP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006229">
        <property type="term" value="P:dUTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00146">
        <property type="entry name" value="dCTP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011962">
        <property type="entry name" value="dCTP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02274">
        <property type="entry name" value="dCTP_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="3">
        <location>
            <begin position="63"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="100"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>dCTP</name>
            <dbReference type="ChEBI" id="CHEBI:61481"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="177" mass="20190" checksum="F679BBECD0F946C3" modified="2012-06-13" version="1">MILGDRDLKYYIKTKRIVIEPFDEEIVRENGLDLRLSNEIARFKSNSEPVDSKANFLDPFQYYTIEKGESFVIQPNERVLLNTLEYVKLPDDLMAFVNLRSTFARLGLIAPPTIVDAGFEGNITIEVVGGAFPVKLHVGDRFIHLIFAKLLSPVEKPYSGDYQGQKGVMFPKMFNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1P0</accession>
    <name>I0A1P0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FFONT_0909</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_0909"/>
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    <dbReference type="eggNOG" id="arCOG00707">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OMA" id="AHHKDAW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="10">
        <location>
            <begin position="4"/>
            <end position="206"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012818"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="608" mass="68159" checksum="AF2E7FB8C1D1132A" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1S1</accession>
    <name>I0A1S1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase, family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42928">
        <property type="protein sequence ID" value="AFH42928"/>
        <property type="gene ID" value="FFONT_0940"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="F:GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR45919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="419" mass="47718" checksum="13DBD5F3E30FF895" modified="2012-06-13" version="1">MKSAEIDAFKSDALVAHHFWNTAGGSELLSASVALAFSLIGYMPTLVSVSKIDDLVIKKSFGIDLSSFPRTHAAISINSFGLMMRILLRREINKVIKSTDPEFLFVDSPFYDGNKVRKNGIKVIEYIHFPIEAYFMSLNDRKINLNGDPYIKENYNGIIGSLYFSMFGKISSKFKRENPFDSAHLVLVNSEYVAKIVSSIYSQKPKVLNPPIPPNNIDPSELKDFSSRENSIVLLGRFSREKRYHWVIENIVPKVVNEVGDSKFYFVGYSKGRRSASYVNELVSILNKLNISYSFDIRKNARVYLLENLDKEIVNEVLRRSKVLLHATINEHWGISIAEGMSFGLPVVIHKSGGLWSDLALAGKSGVGYENAEEAIQEIVKLINDEKTWRHYSSMSLRRSDDLRIEKFVQRFNEYIKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1T3</accession>
    <name>I0A1T3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">V-type ATP synthase alpha chain</fullName>
            <ecNumber evidence="11">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">V-ATPase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">atpA</name>
        <name evidence="13" type="ordered locus">FFONT_0952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="11"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0952"/>
    <dbReference type="EnsemblBacteria" id="AFH42940">
        <property type="protein sequence ID" value="AFH42940"/>
        <property type="gene ID" value="FFONT_0952"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0952"/>
    <dbReference type="eggNOG" id="arCOG00868">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008162_3_1_2"/>
    <dbReference type="OMA" id="TAFVQVY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="PTHR43607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="12">
        <location>
            <begin position="209"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="217"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFH42940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="574" mass="64307" checksum="E878BE2B589C43BD" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1T6</accession>
    <name>I0A1T6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">V-type ATP synthase subunit I</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FFONT_0955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0955"/>
    <dbReference type="EnsemblBacteria" id="AFH42943">
        <property type="protein sequence ID" value="AFH42943"/>
        <property type="gene ID" value="FFONT_0955"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0955"/>
    <dbReference type="eggNOG" id="arCOG04138">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025558_0_0_2"/>
    <dbReference type="OMA" id="MAVNIMA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="PTHR11629"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="522"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="578"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="222"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="667" mass="75448" checksum="8538114696E98D11" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1T8</accession>
    <name>I0A1T8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="1">FDTS</shortName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidylate synthase ThyX</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thyX</name>
        <name evidence="2" type="ordered locus">FFONT_0957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0957"/>
    <dbReference type="EnsemblBacteria" id="AFH42945">
        <property type="protein sequence ID" value="AFH42945"/>
        <property type="gene ID" value="FFONT_0957"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0957"/>
    <dbReference type="eggNOG" id="arCOG01883">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077585_0_0_2"/>
    <dbReference type="OMA" id="ESTRYCN"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="1">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="160"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="272" mass="32082" checksum="8E22A101EB50E3D6" modified="2012-06-13" version="1">MKVTLISYTKECEKLIAVAAKQTITQKEFSESWNEMKEDEKKEWLKETMSRGHTSPWEHCTYTFLIEDVSRVLTHQLVRHRLASYSQLSQRYKRIKEIENYYVIPKSILKKGDKALEKYINSIKKSFEEYQELINMGMPPEDARYVLPQAVKTKIVVTMNARELLNFFGLRMCMKAQWEIRALAWNIYYIVKSIHPDLWKFVGPRCLQLENMARMKPIELEELLKNDNINLIIEKCPEGVARENIKLCVRTALNDIREFLESANPNNGENKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
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        <submittedName>
            <fullName evidence="3">Carboxyl transferase, catalytic subunit</fullName>
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        <name evidence="3" type="ordered locus">FFONT_0966</name>
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    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH42954">
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        <property type="gene ID" value="FFONT_0966"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="266"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="521" mass="57245" checksum="A07AFB3658E8FDF1" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1U8</accession>
    <name>I0A1U8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxyl transferase, biotin-binding subunit</fullName>
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    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0967</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="70" mass="7840" checksum="52E0B9B2CF14A750" modified="2012-06-13" version="1">MVVVTSKVPGKIVDILVKDGDEVKKNQVLLKIESMKMIIETRSPKDGKVEKIFVSKGDFVQKDKPLLEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Y5</accession>
    <name>I0A1Y5_FERFK</name>
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        <submittedName>
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        <name evidence="2" type="ordered locus">FFONT_1004</name>
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    <organism evidence="2 3">
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="KDAPNRE"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="378" mass="42057" checksum="3D37CFFD313C67DC" modified="2012-06-13" version="1">MISMNKYWYLTIGIIIGLAIGGVLVYTIQNHEIKANPATNITTFNVGAAGTLKFSFSQLLSIYSNYFPSVQQGSPFFAGSGEVAQKEVTTKSYSIVAAADTSTIPSVLFPANLSDYEIAFGYTQMTIIVDLNTPYGREVYSLWNQSIQQIPYSDTWNDTWRKIFNIIALNPNTVVGVSNPFTDPSGYQAQCMLKLAGLTFYGNSSYLWSAIYSNPSKYIMRNTETDLLSLMTANNTVQFILSAYLSNAIPQVQYYQQNGYNITYITLPSAINLGDLSYVNYYKQVNVTWTQLGTTKTFSCKPVIYTITIPSNVQNKQASIDFILLIYSPIGQQVLKSYGIQPINPGIVYGNYTDVPQEIKIFTIPLDNVTNMKGLFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Y7</accession>
    <name>I0A1Y7_FERFK</name>
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        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
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    <gene>
        <name evidence="6" type="ordered locus">FFONT_1006</name>
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    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="228"/>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="348" mass="39423" checksum="B8574FA958DCD9DE" modified="2012-06-13" version="1">MSIKKSEIAAIYGNKLPVGCNLCFSGIKAVIFLTGLCNEKCFYCPVSYLRRNKDLIYVNERKIENFEEIFEEIERSGAKSASITGGEPLIVFDRTTKIIELLKQNFGSNFHIHLYTNGILINEDVLKKLEKAGLDELRIHPTIDGIEKKVVIAKKVTSLSVGVEIPSLPGKEEWMIKLAEFLDKAGADFLNINELEANETNIKNLRINGFVISDNGIVVNGSRETAMKVIEYAKKHSLKIPIHFCPAIFKDAVQTRNRFIITAQNDIKIYEKADGGLIKFGILEPESTDIEIEKFIDEGLIQRCRDSLCFHLDDLKKLKDLINKKGKAYVVEAHPTRERFIVNKSRLF</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AFH43017">
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        <property type="gene ID" value="FFONT_1029"/>
    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AFH43017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="196" mass="22038" checksum="781CB89F5165B9DD" modified="2012-06-13" version="1">MSLSQEKDKIFIGIDLSAKENKPSPICIFFSLSRTFNFFTIHKNEEIINIIDSLYGLKKRTKIYVLFDSPLFSESGVKFRSMDLIALKLGGKLLPLSFKSIKELGQRGELLSHQLLSKYKELVIFETHPYTASKILGYSNTKQLSEKLLGTSLNKGLSDAFACCISGIIFFKIGGIAIEDDYSHFTMIFPKNISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A215</accession>
    <name>I0A215_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="304" mass="35790" checksum="2CB94EEAD4C8C024" modified="2012-06-13" version="1">MYKMIEGFIVEYKNTYWIIRSYYDFGDYLFAIPRYVFDMNRTIKEVKEAIEFVSTYYPEKLQECKCFGRKVPFLKKSEVGRVLDPRSVALEVSNPLHKKAMKLLSELREHTNSVDIGITGGILVGKRTSDIDVIVYGRKTCEEVYKFLMESKTLEKYGRNEVLNLLENRREKYYNELIVKREMEKILQGKFEGVDVYIRLVPYTPKCPQKCTRSIEKLGTITTNVTITDSSLSYLYPCSYRAFDNKSRKEITITSDRGRFCEILKPGDFAFVRGELERVNDEGKTFLQLYLWDNEHFLLPIEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
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    <name>I0A220_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sugar phosphate nucleotidyltransferase</fullName>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1039"/>
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        <property type="protein sequence ID" value="AFH43027"/>
        <property type="gene ID" value="FFONT_1039"/>
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        <property type="term" value="F:transferase activity"/>
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        <property type="entry name" value="Hexapep"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="385" mass="42781" checksum="57C7E64A7A1AB064" modified="2012-06-13" version="1">MVSLIYLSHNEIESVYPITESGEPLPNLKLLGKPIGVRVIESFENEGINDMSVYYSNISSEVYELIGKRVKLEETGKLDFLNSLKNAVENSNSQEIILVLGSFLLNEGFIRELLYKWNEKGSSMLIALVPGSQKLEDLVWKIGVDVEFVEGNVKKAYLIKNNASSFYIFSGIIVSEKEFLLRKIDLSIKDYNQALLKLINETNPPFYIYTGEYVSFASPWSILNAMKMLLQKISGQFISKEAKVSPTAVLEGPVLIEDGAVIDHYTVIKGPVYIGKRSFIGAHSLVRNYVSLEESSVLGSGVEVKRSYIGPRVTIGSNCLVTDSILGENATFKPFVVTLNYDPHEAKRLGEFYIKRGVILGKGSLINGGSVLKPGTIIESRKIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A243</accession>
    <name>I0A243_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thermosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1062</name>
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    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Mardanov A.V."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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            <begin position="32"/>
            <end position="51"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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</entry>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Gumerov V.M."/>
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                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS51151"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43072.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="124" mass="13913" checksum="54DD875F8B1EB645" modified="2012-06-13" version="1">MFKMNPSDMKKMMKRMGINVDVEEVKDAERVLIETSGDKNFVVEQPSVTFLKMKGQTIIYVIGSLKEIEKEETTHQKRELEILEDDVQLVAAEAGVSLEEARKALEITNGDIAQAIMLLSAKKG</sequence>
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        <submittedName>
            <fullName evidence="2">50S ribosomal protein L44e</fullName>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
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    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1092"/>
    <dbReference type="EnsemblBacteria" id="AFH43080">
        <property type="protein sequence ID" value="AFH43080"/>
        <property type="gene ID" value="FFONT_1092"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1092"/>
    <dbReference type="eggNOG" id="arCOG04109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114645_3_0_2"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_L44e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="PTHR10369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="72" mass="8512" checksum="EAD700B77C3C3A6A" modified="2012-06-13" version="1">MIYKAGKRRALSIGQRRYVRKQEGYGSKRKPEQKRYAKTTKKQVIKLKCSECGYIQHRKGLRLKKLELTEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A276</accession>
    <name>I0A276_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcn</name>
        <name evidence="6" type="ordered locus">FFONT_1095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1095"/>
    <dbReference type="EnsemblBacteria" id="AFH43083">
        <property type="protein sequence ID" value="AFH43083"/>
        <property type="gene ID" value="FFONT_1095"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1095"/>
    <dbReference type="eggNOG" id="arCOG00488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_1_0_2"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PTHR11352:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="4">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="5">
        <location>
            <begin position="109"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="229" mass="25687" checksum="F712FF4048E42DE3" modified="2012-06-13" version="1">MGISKILEEVAIKADKDGIRLRAMDPSHVMLIDLFFPSSSFESYEANSEIIGINLENLSDMLKRAKKGDKLEIVTEGNKFQLKFIGKFSRIFTESTVDVPYQELPDINLEFKADIRLSAQIFKDSIEDVEFLGDNIYFIANESKFTILNESEIGKAIVELDKDSGNIISLVCEGEQKSLYGLEYLESLLYSAEVADIVSIQFSSGIPTKITFEFPQGARLVSYIAPREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A293</accession>
    <name>I0A293_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1112"/>
    <dbReference type="EnsemblBacteria" id="AFH43100">
        <property type="protein sequence ID" value="AFH43100"/>
        <property type="gene ID" value="FFONT_1112"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1112"/>
    <dbReference type="eggNOG" id="arCOG00109">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_6_2_2"/>
    <dbReference type="OMA" id="FIDINPV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004557">
        <property type="entry name" value="PrmC-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00537">
        <property type="entry name" value="hemK_rel_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="211" mass="23459" checksum="951E50A814AB06C8" modified="2012-06-13" version="1">MCRSNRKVRWGYFLCIPEGVYDPSDDTYMILEYLSSHPEIVKNKKVLDIGTGSGIIALHSLVLGASDVVATDVNCLASYSTCLNLSSFDKQQERFSVVIGNKVTFLRSRSGFDTIIINPPYLPIEPKNANDPFELQWAGGKEGIDFSLSILDEIPEILSSGGTLLLVSSSLGNLEILYRKMSEIDMKFGIVSSKSFFFEDLYLIKGEKNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I0A296</accession>
    <name>I0A296_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal recognition particle 54 kDa protein</fullName>
            <shortName evidence="8">SRP54</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">srp54</name>
        <name evidence="12" type="ordered locus">FFONT_1115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="8">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1115"/>
    <dbReference type="EnsemblBacteria" id="AFH43103">
        <property type="protein sequence ID" value="AFH43103"/>
        <property type="gene ID" value="FFONT_1115"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1115"/>
    <dbReference type="eggNOG" id="arCOG01228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_2"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 8" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="9">
        <location>
            <begin position="98"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="10">
        <location>
            <begin position="99"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="188"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="248"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH43103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="453" mass="50901" checksum="D668EB5B5973B372" modified="2012-06-13" version="1">MSNIFSGIKEAIKKFLSSTSPYEQSVEEFIRELQRILIKSDVNVKVVFEFTSKIRKRALEEKPPQGVSRRDWFIKIVYEELISLLGGEEELNVLPKKKPYVIMLVGVQGSGKTTTAAKLAWYYKNRGYRVGLIAADTFRAGAYEQLKQLAEKVGVEFWGDKGLNDPAEISRKGLEYHLSKKAEIIIIDTAGRHGYGEESKLIDEMKAIADAVKPDEVILVLDASIGQKAYDLAKKFHEATPIGSIIITKLDGTAKGGGAISAIAATGAKVKFVGTGEKVDEIEPFRPKNFASRILGMGDIEAILERVYSTMSQNELEEMADSLMSGNLNMKLIYKQIKQIRSMGPIGKILRMIPGLSMSLPEDEGALKVSEKKMDMWLNIINSMTYEEMEKPELLEREKSRIRRIAIGAGVAQEDVRELLNYYNYIKKLLKQLKRRKSLLKKFGGADEFLEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2A0</accession>
    <name>I0A2A0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1119"/>
    <dbReference type="EnsemblBacteria" id="AFH43107">
        <property type="protein sequence ID" value="AFH43107"/>
        <property type="gene ID" value="FFONT_1119"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1119"/>
    <dbReference type="eggNOG" id="arCOG01259">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="275" mass="29263" checksum="5F2294EE40654067" modified="2012-06-13" version="1">MGIIVMTKVYVITGGGGGIGKATAKLLAKKGSLLLADIVPEALKKVESELKGEVNGSIETMVTDVSNERDVKELAKKASELGDLGAIVHTAGISPTMADAKRIFDVNLVGTAYVLKHFHNIATSGSVGVMIASMSAYMVPRDTNVSNLLKDPLSQGFSEKLSVIAKSDPGMAYSLSKLGVILLVEDQAEAWAKKGARLVSISPGIIDTTMGRRELEMQPAMRQLLQMTPLSRMGRPEEIANVIEFLVSEKSSYINGTDILVDGGVISSLKKAFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2D2</accession>
    <name>I0A2D2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Linocin_M18 bacteriocin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_1151</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Encapsulin nanocompartment</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1151"/>
    <dbReference type="EnsemblBacteria" id="AFH43139">
        <property type="protein sequence ID" value="AFH43139"/>
        <property type="gene ID" value="FFONT_1151"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1151"/>
    <dbReference type="eggNOG" id="arCOG05908">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067492_0_0_2"/>
    <dbReference type="OMA" id="EKTHFGE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007544">
        <property type="entry name" value="Linocin_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04454">
        <property type="entry name" value="Linocin_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1284">Encapsulin nanocompartment</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="360" mass="40767" checksum="FD6BD0439C72CE22" modified="2012-06-13" version="1">MLSKNPLEIPMDRKLKANEIADALRLSIIAELDAINLYLQLSKSVEDENVKKVFEDVAKEEKTHVGEFLALLNSLDAEQKSELEAGLKEVKELTSMNIKDDPSNLVSNEEKKEENKVKNSNGDFLSIVVNEYQKALEEMRIFRKYLPIKRIEKGTQAIFVEKSDEKGEREIIPLNEIESYFIVSQMSIDSIDKNGELEAPDLYRSALELSNNEDRLILETILNREGTIKLPVDEWNEPSQSVNDIANAFTEILRSGATKPFALFISPKKYVKLLAISDKTGTTDLERIKAFIDNIVILPILPDNVTIIVSLQPRILELVIGIDSEIRYLGPEKGYHNFRAREKLALKVKDARGIAILEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2D3</accession>
    <name>I0A2D3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1152"/>
    <dbReference type="EnsemblBacteria" id="AFH43140">
        <property type="protein sequence ID" value="AFH43140"/>
        <property type="gene ID" value="FFONT_1152"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1152"/>
    <dbReference type="eggNOG" id="arCOG00022">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140805_0_0_2"/>
    <dbReference type="OMA" id="WKDSPWH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="158" mass="18546" checksum="11C8630CBC8A6AFD" modified="2012-06-13" version="1">MVEEEIKKEVKEFAILEKEYAKILLELSKKIKHKALSSIFESLSKDSEKHATLYETISELLSNEQPFISEEDFRLIERTINEHITTEAKMIEESRKILNNIKDPRVRLLAAIIYEDEEKHHKLLLTVKEDIAKKETFSETDFWNMVWRDSPYHGAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2D9</accession>
    <name>I0A2D9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1158"/>
    <dbReference type="EnsemblBacteria" id="AFH43146">
        <property type="protein sequence ID" value="AFH43146"/>
        <property type="gene ID" value="FFONT_1158"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1158"/>
    <dbReference type="HOGENOM" id="CLU_2504814_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="85" mass="9573" checksum="2054DE5408162552" modified="2012-06-13" version="1">MRKMGELCMLKIANSEEGISAEISLYDESTGKMVRREELGKEKNIRQISIKNSVLITSGIFGFTITLIVKDVTDIRLNNDILIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2G4</accession>
    <name>I0A2G4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="8">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">tyrS</name>
        <name evidence="10" type="ordered locus">FFONT_1183</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="8"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1183"/>
    <dbReference type="EnsemblBacteria" id="AFH43171">
        <property type="protein sequence ID" value="AFH43171"/>
        <property type="gene ID" value="FFONT_1183"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1183"/>
    <dbReference type="eggNOG" id="arCOG01886">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035267_1_1_2"/>
    <dbReference type="OMA" id="YIGFEIS"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02009">
        <property type="entry name" value="Tyr_tRNA_synth_type4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023678">
        <property type="entry name" value="Tyr-tRNA-ligase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="234"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>L-tyrosine</name>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH43171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="364" mass="41497" checksum="BE05963400FCD1B0" modified="2012-06-13" version="1">MDVEEKIKLITRNTEEVVTVEELRDLLIRGEKLEGYLGYEPSGLFHIGWMVWAYKAKDLVEAGVNLRLLEATWHAWVNDKFNGNMQVIKDDAKYIRHSLKAIGIPVEKIKFIDAEDLVSDKDYWALLLKVAKNTTLARAKRTLTIMGRKEEEAELDSSKIIYPFMQATDIYYMGLNIALGGIDQRKVHMLVRELAEKVGAKKIVAIHTPLLTGLQGSGRAGGGSSKDEIMSEVKMSKSKPESTIIIHDSPEDIREKIMNAYCPKQVVEFNPIIEINKYLLFSQDNFSLYVERPSEYGGPIEIYSYDELERMYLKGEIHPLDLKKATADALIKKLEPARKYFEDNKEAKELALKIASELKIEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2H2</accession>
    <name>I0A2H2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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            <begin position="4"/>
            <end position="226"/>
        </location>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="319" mass="36461" checksum="E49F3B99BAEFCDB2" modified="2012-06-13" version="1">MTRALVIGANGQIGFELVPVLRKLYGSENVIAGYYPEKIDIKLEAPREYIDVLNVDLVESVVKKYDVDEIYNLAAILSATGEKNPQLAFKTNLLGVFNVLEVARKYGTRVFWPSSIAVFGPTTPKYSTPQHTIIEPTTMYGITKYAGELLSRYYVNKYDLDVRGVRWPGIISSEALPGGGTTDYAVEIFYYAIEGKKYTCYLHEDTMLPMMYMPDAIKSIIQLMNADKSKLETFVGYNVSAFSFTPKQLEKEIKKYIPEFQVEYKPDYRQQIADSWPRTIDDCVARKEWGWSPEWVFESMVKDMLMKISKKLGKSINIK</sequence>
</entry>
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    <accession>I0A2I2</accession>
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
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        <property type="entry name" value="SSF141000"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43189.1"/>
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    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="96" mass="11264" checksum="4C732F7389737CD2" modified="2012-06-13" version="1">MEKENDINREIINHLSFLSRIKLDEDEVEKMIEDLKMIKSYIDEVLSIEVEDEGEIYLTTGRLREDEVTNQMINPADFIKPEFIEDGYVKGPKVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2J8</accession>
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        <submittedName>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP5/NOP56 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_1217"/>
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        <property type="term" value="C:box C/D RNP complex"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0030515">
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            <end position="379"/>
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            <end position="424"/>
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            <end position="424"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43205.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="424" mass="48098" checksum="78B1E063C6089F72" modified="2012-06-13" version="1">MMKKYLTQHIVGAFLIDEKGEVIKKSFSNKDIDENVEEMLQFESGNLTKQIIGLIEDISSGDTVVVETDALSRALLKQKPSLNVVVEKNAEVFRTFRGKIREIAISGGFFKGEDEFQMYIHQFNMEYTRRKLRKAAQKRDQLAAQAIRAIDDLDKTYNLFVIRLREWYSVHFPELDNLVPNHEQYVRLVAELGHRDNFEVSSIVNLGFSQDKAEKLTDAAKKSIGADLSDFDIKPIQTLARMAWDTYVLREDLAGYIESVMKEVAPNITALVGSLLGARLISLAGSLENLAKLPASTIQVLGAEKALFRALKTGSRPPKHGIIFQYPEIHKAPRWQRGKMARTLAAKLAIAAKVDAFTGRWIGDKLVEDLQKRLEEIKKIYAKPPARKPTEAVQQQTRPEAKRREFPKQKKMKGKKRGFGGKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2K6</accession>
    <name>I0A2K6_FERFK</name>
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        <recommendedName>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH43213">
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        <property type="gene ID" value="FFONT_1225"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1225"/>
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    <dbReference type="OMA" id="NPNYVRR"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="129" mass="14246" checksum="39DD21EB59613CD7" modified="2012-06-13" version="1">MGIYQENDLKKSSGGKKTRPYKVKRKALFGGYFTETKVHSEDEKEIIKVRGGNIKIKLKKASKAVIMSKDGKTVKVEKISRVVETPSNKEFARRGIITKGSIIEVESGKALVVSRPGQDGVINAVLIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2M2</accession>
    <name>I0A2M2_FERFK</name>
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    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43229">
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        <property type="gene ID" value="FFONT_1241"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1275387_0_0_2"/>
    <dbReference type="OMA" id="KWGYLIV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="240" mass="27510" checksum="F33F7077B6B0D7BB" modified="2012-06-13" version="1">MIMKSFSIQVSSKDSRSYDVKQCEKSGIEGIDELVGCIPKGIIAEFYGDFQLVLQTSYKVIANFHCIDGTAVGIMQNELINYDFYMLRMYARSFGCNTNDMLVSRAFRLEDAINMLKSASNIDAENIAIIDPYIHSPSEPRNYWKLARLIAMMRALSAEGKRVLLFNRVSKFGRFLPEGGNLSHHSAYMIVRLEIVDRRSYRATLIKHPSRPEKSLVRSINEILSVRDKWEGQLPLLEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2M9</accession>
    <name>I0A2M9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">D-3-phosphoglycerate dehydrogenase (SerA)</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ordered locus">FFONT_1248</name>
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    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1248"/>
    <dbReference type="EnsemblBacteria" id="AFH43236">
        <property type="protein sequence ID" value="AFH43236"/>
        <property type="gene ID" value="FFONT_1248"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1248"/>
    <dbReference type="eggNOG" id="arCOG01755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="KVISCHS"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
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    </dbReference>
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        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
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        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
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    </dbReference>
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        <location>
            <begin position="9"/>
            <end position="320"/>
        </location>
    </feature>
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        <location>
            <begin position="112"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="324" mass="36303" checksum="C3F14FCF918E6D80" modified="2012-06-13" version="1">MVIQIKVLYIHKPNEVELEFLKKEGLEVSFHQHPQQTYEEWLEKEIINADIIVVPPAHPFGKEFIGKAKNLKLIMVSGSGLDKIDIEEASKRGIYVANAPDSIAEAVADHIIALILAHYRNIIKGEEYLRSGKWVGRIPSELIGHTIHGKKIGIIGMGRIGAELAKRMIAFGAEVSYWDRKVKPEVEHLININRIELDKLLEESDIIAVTIALTPETKHLLNKERILKVKKGALIVNTSRGSIIDEQALIERLKSGEIYAALDVYETEPLPTSSPLLSMKNVILTPHIGGYSWEATKETSEYVARSIVEFAKEGKLPKTVVNRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2P4</accession>
    <name>I0A2P4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1263"/>
    <dbReference type="EnsemblBacteria" id="AFH43251">
        <property type="protein sequence ID" value="AFH43251"/>
        <property type="gene ID" value="FFONT_1263"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1263"/>
    <dbReference type="eggNOG" id="arCOG01341">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1801620_0_0_2"/>
    <dbReference type="OMA" id="PIENAMN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00293">
        <property type="entry name" value="TIGR00293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="143" mass="16506" checksum="2FE37E8F42F2EF1C" modified="2012-06-13" version="1">MEYMSRTVQIDAEALLQTVANLEKYLESLRNAIGLLNERLLEVKIAREALKRINSENTSDIIVSMDKDSNLMVKLKANIDGNPLVHLGLDIYAELPYDRAESVLAERENSITEELKRMSKEYDEKNKEYQKLQSLIYALSQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Q4</accession>
    <name>I0A2Q4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl1</name>
        <name evidence="6" type="ordered locus">FFONT_1273</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds directly to 23S rRNA. Probably involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1273"/>
    <dbReference type="EnsemblBacteria" id="AFH43261">
        <property type="protein sequence ID" value="AFH43261"/>
        <property type="gene ID" value="FFONT_1273"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1273"/>
    <dbReference type="eggNOG" id="arCOG04289">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_4_0_2"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_A">
        <property type="entry name" value="Ribosomal_L1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023669">
        <property type="entry name" value="Ribosomal_L1_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="219" mass="24641" checksum="07F25F1B3D03F57D" modified="2012-06-13" version="1">MAQATTLTEKIENALREVLEKSPKRNFKQSIEMIITFKEIDPKKPEFKIRENVFLPNAPKKEPEICIVADGDLALQAKNLNVKQVIDKAILDEISKDKKKAKKIAKNCDVILVQTDLMSQVGRTLGPALGPRGKAPIPLPPRSDLQSILERYKKIAIVRIKDQPQIQVKIGTEDNTLKELTENAIAILNVIENKLKTLSNVDAIYFKKAMGPPVKIRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2V3</accession>
    <name>I0A2V3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Electron transfer flavoprotein beta-subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1322"/>
    <dbReference type="EnsemblBacteria" id="AFH43310">
        <property type="protein sequence ID" value="AFH43310"/>
        <property type="gene ID" value="FFONT_1322"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1322"/>
    <dbReference type="eggNOG" id="arCOG00448">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_2_1_2"/>
    <dbReference type="OMA" id="YYVYDAE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ETF" evidence="1">
        <location>
            <begin position="31"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="270" mass="29457" checksum="8DF0D9627DDFF94E" modified="2012-06-13" version="1">MDDAIMEGSFKIVVLMKPVPDMEKVKFNVEKGTIERESSELVINPFDLHALEVAAQIKEKVNGTVTTISMAPPHAADALKESIARGSDRAILLSDRKFGGADTLATAYALASAIRKLGIPDLIVAGEKSVDGDTAQVPPLVAEMLGIPHASYVSKVIDIKEKAIEVITEQEAPYRVELRLPALIQVTKEVAKPRVPTLKDKLKAKKYEIEVWSADKLSDVANPDFFGLKGSPTWVSKIIVPKPKPRSKQVFNAEEGIKKIIEILSKEGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2W4</accession>
    <name>I0A2W4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="7">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">t(6)A37 threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA threonylcarbamoyladenosine biosynthesis protein Kae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">kae1</name>
        <name evidence="9" type="ordered locus">FFONT_1333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="7">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="7"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1333"/>
    <dbReference type="EnsemblBacteria" id="AFH43321">
        <property type="protein sequence ID" value="AFH43321"/>
        <property type="gene ID" value="FFONT_1333"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1333"/>
    <dbReference type="eggNOG" id="arCOG01183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_2_2_2"/>
    <dbReference type="OMA" id="MRIMCEE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022449">
        <property type="entry name" value="Kae1_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="PTHR11735:SF14"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TsaD" evidence="8">
        <location>
            <begin position="39"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="142"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
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        <location>
            <position position="125"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH43321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="345" mass="37500" checksum="4D52FF215D241C85" modified="2012-06-13" version="1">MRIHGVLGEEKLIRVLGIESTAHTIGVGIAQNREPHILANEKDKYEPEKGGIHPRDASRHHAEKIGSIISRALKKANLKIDDIDAVAVALGPGMGPCLRVGATAARAISSYFGKPLIPVNHAIAHIEIGNLLSGFSDPLVVYISGGNTSIIAYKQKRYRVFGETQDIALGNLIDTFAREAGLAPPYVVNGRHVVELCAERSKEKKLLDLPYIVKGQDVSYGGLLTSSLKMIGKEDLGDVCYSLVEISYSMITEVAERGLAHTRKKEVILTGGVSASKVLTEKLEKMSALHGAKFFSVPPAFAGDNGAMIAWTGLLEYVHGIIIDPSMAYISQRWRVEEVEVVWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2W7</accession>
    <name>I0A2W7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Shwachman-Bodian-Diamond syndrome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_1336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43324">
        <property type="protein sequence ID" value="AFH43324"/>
        <property type="gene ID" value="FFONT_1336"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1336"/>
    <dbReference type="eggNOG" id="arCOG04187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043216_2_0_2"/>
    <dbReference type="OMA" id="AVNPQMD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EFG_III/V"/>
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    </dbReference>
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        <property type="entry name" value="Ribosome_mat_Sdo1/SBDS_C"/>
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    </dbReference>
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        <property type="entry name" value="Sdo1/SBDS"/>
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    </dbReference>
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        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
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        <property type="entry name" value="PTHR10927"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SBDS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SBDS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="SBDS_C" evidence="3">
        <location>
            <begin position="99"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="232" mass="26140" checksum="48DBE6168F5F32BF" modified="2012-06-13" version="1">MSSKEYIIAKYESKGKHFEILVDPELVFEYKESGKPNIEEVVKSEFIYKDAKKGLKASPEDIKSVFGTEDFLAVAEKILKGGELQLTTEQRRKMLESKRKMIITYISRNAIDPTTKLPIPPQRIEKAMEEARVSVNLNESVEKQAINIVKAIARQIPIKMAKALLEVNIPSSYASKAYSNAKTLGIVHKTNWNQDGSVTFELEIPAGMQEEVIDKLNKLTKGEVSVKVLKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2W8</accession>
    <name>I0A2W8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exosome complex component Rrp4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rrp4</name>
        <name evidence="5" type="ordered locus">FFONT_1337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RRP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1337"/>
    <dbReference type="EnsemblBacteria" id="AFH43325">
        <property type="protein sequence ID" value="AFH43325"/>
        <property type="gene ID" value="FFONT_1337"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1337"/>
    <dbReference type="eggNOG" id="arCOG00678">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071769_0_0_2"/>
    <dbReference type="OMA" id="GPYIPEV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00623">
        <property type="entry name" value="Exosome_Rrp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023474">
        <property type="entry name" value="Rrp4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PTHR21321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="68"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="242" mass="27248" checksum="163507BB9ADDB865" modified="2012-06-13" version="1">MEKPVFYVQQRDIVLPGDLVGEGKIETNSLYIYNIGNKYFSSIIGMVEIKDDKLFFYPKEQIYIPKPNDLVIGLITDVGPTYWDVDLNSPYEGQLPVSETPLRQTHATVDTMRKFLSIGDFVALKVLSFDRLRDPLLTMRGKGLGKIYGGKVIDIAQHAVNSLINRKRALVEAIVKETKTEILISNNGRVWIKGTDSILEDLAVLAIKKLESVDLYSITSSEIINFIQIEKQKRGIGDVAQQ</sequence>
</entry>
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        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
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        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="17"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="327" mass="37054" checksum="7CE1987356F375DD" modified="2012-06-13" version="1">MGPPEGSYEVVERCIKSGVLERYPDYNYEKLKRAISSFYGCREEDIVPTSGAGEAINLAIFALKPKWIYVLEPSYGEYEVLSKALGISYKPVFYRKSGDVFSLNFSDLEEACGREDSLIVITNPSNPLGIYIERGEIIEKLSRCRARVLMDEAYSELCSRCAIELGSGIPENFLLVRSMTKWLSLPGIRLGFLFSSSREVLEKIDAVRQPWNVGSLADCFARELLSRKDEAREFIMRSRRYIEGERKRMLNELKSLGLKPYDSSANFILVESPRGLDLSFLLKGEGIHVRSCASFKGLGSSFIRIGIRKPHEDDELINALKRVIENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ70</accession>
    <name>H9ZZ70_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0284 protein FFONT_0031</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0284 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0031"/>
    <dbReference type="EnsemblBacteria" id="AFH42027">
        <property type="protein sequence ID" value="AFH42027"/>
        <property type="gene ID" value="FFONT_0031"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0031"/>
    <dbReference type="eggNOG" id="arCOG04272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053134_0_0_2"/>
    <dbReference type="OMA" id="TRWVAED"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01086">
        <property type="entry name" value="UPF0284"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002805">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38811">
        <property type="entry name" value="PTHR38811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00303">
        <property type="entry name" value="TIGR00303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="351" mass="36791" checksum="A5D353FF0E2F52C8" modified="2012-06-13" version="1">MHGSFKTEEMRKGKAVVVCVIASTLTSTIPNISLAGEMAAATLFTPALDVEYVQYGKPQSIDSIPTTPSGIPTPAVITRAALQLSNAPFIVVNSGSYVEPKLPALTLPSRRVGGRIDKEEALPRGTSKRLFSEAKTAGKTFSSLSDVVLIGESMPGGTTTALSILKGLGMGDCSSVSSSSNVNPIDIKKSVVEAALKRAEGMDDPFEINDVLGDPLHISIAGIAIGALSGGSHVILAGGTQMLAALALMRASGEEFDKEKVSIATTKWVFDDKGEKMGKLVGSLAPGASLVYADLSFSDSPFEGLKAYDEGFVKEGVGAGGTSVLALLKGRSVEDLKRSIYIEYERLMKMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ72</accession>
    <name>H9ZZ72_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0033"/>
    <dbReference type="EnsemblBacteria" id="AFH42029">
        <property type="protein sequence ID" value="AFH42029"/>
        <property type="gene ID" value="FFONT_0033"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0033"/>
    <dbReference type="HOGENOM" id="CLU_3147817_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="48" mass="5479" checksum="2D3AB26DFBEC8EAB" modified="2012-06-13" version="1">MLLVRPSSGAASHKMQLDEGGEDELLWNRPAQMIWGIELFKKYVFKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ86</accession>
    <name>H9ZZ86_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0048"/>
    <dbReference type="EnsemblBacteria" id="AFH42043">
        <property type="protein sequence ID" value="AFH42043"/>
        <property type="gene ID" value="FFONT_0048"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0048"/>
    <dbReference type="eggNOG" id="arCOG05931">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1551755_0_0_2"/>
    <dbReference type="OMA" id="YRHESED"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="172" mass="19714" checksum="DB57CB153F7F900F" modified="2012-06-13" version="1">MEECSGCKELIWDYRTGDIICSESGEICEKIYVEEDAPARVEGEGKKSRGRKKDLQRSYRAYFRLLKKAKRKGLLISEEGFMRYLSSGKQVMVFSHPKTPSLMRFIMENEIIRRAFERVSRDPRFSGRTLRAKAAAAMILASSDSIARIAEVTGLSPEHIARLRKLLKEDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZA4</accession>
    <name>H9ZZA4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas1</name>
        <name evidence="9" type="ordered locus">FFONT_0067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0067"/>
    <dbReference type="EnsemblBacteria" id="AFH42061">
        <property type="protein sequence ID" value="AFH42061"/>
        <property type="gene ID" value="FFONT_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0067"/>
    <dbReference type="eggNOG" id="arCOG01452">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_0_0_2"/>
    <dbReference type="OMA" id="FIRLECY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="327" mass="36677" checksum="6012A163F39F6E28" modified="2012-06-13" version="1">MRLLVITGYGKRLSVEGKVFKIEDRNKSSSKVNPADIESIVIESSGVSITSAAIELASMAGIPIFIIRGRGSPTVISPIYSVKTAETRRKQYSATTGKSGCTLAKSLVRSKISNQAECLRNLNRYFNDEDVRKEVEKLRENSKRAQELQCSENWSSQLRQIESSAARAYWGSLAVFLPESIGFDGRDVDSGDAFNCSLNYIYALLYSECFKKLSIAGLDPYGGIYHVDKAGRMSLVYDFSDPVKPFLDYSLTKERQLLLNIKVSDGVLDEDARKNIILLYDGARKSKVRIYDKTSVTFQEALTSFAFNLAESFRKSEEARMDMSMKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZB5</accession>
    <name>H9ZZB5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated RAMP protein, Cmr4 family</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccales</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42072">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RAMP_III_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36700">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03787">
        <property type="entry name" value="RAMPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02580">
        <property type="entry name" value="cas_RAMP_Cmr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="305" mass="34402" checksum="66A07E6B7D1EDF7D" modified="2012-06-13" version="1">MGLNYNREKALLLLIRAITPLHVGVGEGEHVDLSVQRDEFGFPIIWGTSLKGAIKSQFNRIYGKDEKFIKELFGDDEKPSKLRVLDARLFLIPARTYKKVWTYVTSKQVIERLEPYAELAGFKLDTGVESKGSSTVGNAGAHEPIEKVDVIVNKDYLLEDGKITLNEIFDLTAKSNPTEFNMINTLINKISSIKNEKIEKLIKRIEERGICLVTDEESKSRAIINKSIVIQYRIRLKGDEKVVKEGGLWSEELLPSETLMLSALVVNESDLSKLKNLVEKNPFYLFIGGKESVGRGLAEIYLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZB9</accession>
    <name>H9ZZB9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42076">
        <property type="protein sequence ID" value="AFH42076"/>
        <property type="gene ID" value="FFONT_0082"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0082"/>
    <dbReference type="eggNOG" id="arCOG11242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1840478_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="160" mass="17968" checksum="D086D66144447244" modified="2012-06-13" version="1">MEKERKCQLKSKAKVREKGSSKAISILLILMLLFIGAFLWSYHEENRFSNIVSLKYSETLETNRAIAIPSMGQVTMNYTLPYAGYLKISYSSTSPVYILIGGNFSQQFPGGSYFSRYPLQKESSSGTFIVPVLPGETYITIHNPSILLGTAVTISIEYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZC7</accession>
    <name>H9ZZC7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42084">
        <property type="protein sequence ID" value="AFH42084"/>
        <property type="gene ID" value="FFONT_0091"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0091"/>
    <dbReference type="HOGENOM" id="CLU_3322794_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="38" mass="4152" checksum="3618D47F826DF7D7" modified="2012-06-13" version="1">MVTTVGGKELRSKSLPREVIEIIEAGGLIEKLKKELVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZE8</accession>
    <name>H9ZZE8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
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                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
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</entry>
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                <person name="Perevalova A.A."/>
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        </source>
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    <sequence length="164" mass="18150" checksum="26234BFC0AC05E24" modified="2012-06-13" version="1">MFSIVVVSDRVFKGEAEDESGKLMKGLLESKGFKVDYIFTVPNDPKEILRVLRKSNSKAFIFIGGTGPSPRDITLDTLEEVAWRKIPGFGEAFRMKSFEKVGAAGLISRSEMFLLYDGRVSVVIPGSLDAVKTGFELIAGIVPHLLEEAERFEGEHKKPNVSNK</sequence>
</entry>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR023131">
        <property type="entry name" value="Mth639-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40696">
        <property type="entry name" value="PTHR40696"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04027">
        <property type="entry name" value="DUF371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="153" mass="17091" checksum="8AD02710322B9B0E" modified="2012-06-13" version="1">MPLREIKLIVAASDWIVAYGHYNVLATHRTTFEITKDNYLTKRGNCIIGIKSSKSLKDLSEDMKNNLRNSNTIVRLILYVDGKSDAVTCMGNENLILNSDSKIIVRKSGYIDGSTLCINADKSSNELSREVVKKLREGKKVTLGLIVYSLSLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZP0</accession>
    <name>H9ZZP0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0206"/>
    <dbReference type="EnsemblBacteria" id="AFH42197">
        <property type="protein sequence ID" value="AFH42197"/>
        <property type="gene ID" value="FFONT_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0206"/>
    <dbReference type="eggNOG" id="arCOG01143">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004962_0_10_2"/>
    <dbReference type="OMA" id="HGQFWDM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SER_THR_PHOSPHATASE" evidence="1">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="309" mass="35888" checksum="4C2C4548147996DD" modified="2012-06-13" version="1">MEIAEAVASIINSYINDPYKVEEKLNSFRIYLEERSRNNDKFYVREVTHSGRVFFIGDLHGDFETLKNILSKIDYNSLEKGDLKIIFLGDYVDRGLYQTETLLSVLELESMYPEEIFVLRGNHELLKHAPPYPHDFPTELYSRYGFTRGIRIYNTFVSLVDYLDAAIILNKNIIALHGGLPVTTFQKVSNIYEYLLGRNESEKINVITEILWNDPIEENIDKLPSYRGIGYLWGKQVTNWVADNFGIKMVIRGHEYTELGYKINHDGRVLTLFTTKGYPYKNKTGAYAVIDLSTQTYEENLMDSIHFIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZP9</accession>
    <name>H9ZZP9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0215"/>
    <dbReference type="EnsemblBacteria" id="AFH42206">
        <property type="protein sequence ID" value="AFH42206"/>
        <property type="gene ID" value="FFONT_0215"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0215"/>
    <dbReference type="eggNOG" id="arCOG00185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_2"/>
    <dbReference type="OMA" id="QFRRIQM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="7"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="241"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="273"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="428" mass="48076" checksum="D994EEEAEB75F85C" modified="2012-06-13" version="1">MNISQKVFVDNLSISYKNDEQIVKNINFSLNEGELLLLIGKTGTGKTSILNVLAGNTPRLIKAKVEGNVRINGIDPRDSPSEVLLRNVGLVPQEPSDGVIGDTVEDEVLLSLMFRNDDADVEGWLRLFNLERLYERTTFTLSAGETQKLAILSRVLLNAHVLLFDEPTTYLDEESREGFKEVVFSLLKAGKTVIITGHGATFWDNIPKKIVELPRKAEEVNVEEFSRIEVDRLNKMTYVKVKGLEYQYYPSKVPIFKNINLSFDGPGIILLKGPNGSGKTTFLKLLSGIVRPKRGKIEMSHSALFIPDNPLLYFSKPTPKEELELFAGNLKKEEKERLLKIKIFAKKMKELSSGERRLISLISASLSHHPIILMDEPTVGLDPEYKSTVLDIFKKLSDSGRLLIISSHDREVEKVATEVVEVNKLSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZR0</accession>
    <name>H9ZZR0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FFONT_0226</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an aldehyde + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = a carboxylate + 3 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16421"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.5" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0226"/>
    <dbReference type="EnsemblBacteria" id="AFH42217">
        <property type="protein sequence ID" value="AFH42217"/>
        <property type="gene ID" value="FFONT_0226"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0226"/>
    <dbReference type="eggNOG" id="arCOG00706">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_2"/>
    <dbReference type="OMA" id="PVAIMEM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033726">
        <property type="term" value="F:aldehyde ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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    <sequence length="192" mass="20952" checksum="91AC44ECD7E42B5D" modified="2012-06-13" version="1">MEVFLIKGMCNTYLTSEGILIDAGAKPSDVLLIAKEHGISIKYVLITHYHYDHIKYASEIAERTKAKVVAPEAEADIIEGSARPKFPSLSLRIMSLFATIKPVKVDIKVKDGDEVAGMKAVAAPGHTPGSTAYVSGDIMFSGDAIESDNGKPSLPPRKFTLDQIMAEKSMKKLLELRPKIIYPGHGRPITMQ</sequence>
</entry>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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    <sequence length="272" mass="32181" checksum="1F5664E063C1F756" modified="2012-06-13" version="1">MSSEKERVEALLKKVEEISQESKKSDYKMPVILPFLPAILYFVAVILLAIGMLYSSPSIEYPYSSYSYLQESSHSFNDSVFSSLLILFGFLVIIISIFINFYVIYKWVKRRNDHFLRNMSFYENIAEITNLLKFKRVYSIKSRLNELKDINNNIKSAIVNSILIIVPFYILYVYHFINKDFVKHSQKERLLLSEVIDEIREKVPLFTRRIEEFAEVPDRSTLLYVILYFITCGLFGIYWVYTLTNDPNRHFESHQIIEKELITALKEILSKQ</sequence>
</entry>
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    <accession>H9ZZT1</accession>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZT2</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0248"/>
    <dbReference type="EnsemblBacteria" id="AFH42239">
        <property type="protein sequence ID" value="AFH42239"/>
        <property type="gene ID" value="FFONT_0248"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0248"/>
    <dbReference type="eggNOG" id="arCOG00947">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982127_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="283" mass="33089" checksum="E2C8C9C850E5940E" modified="2012-06-13" version="1">MSFAGAFLTSNEKAGLFHYSISQRVVEILIDDYEETEKGRNLPWSMFSKIKDELTSEEVGNLARRYNPRLIMFNGSNPLKHEWILRSIEPIKKMNIDVGISYSCHKIDENFSSSTAGYYAPKIFNASIIYKNIEKIERCIEFSNLKKEATELQVFLENKGDKAIVDLLLDHFNEFEFPVHIYNWIDEMSKEEINKIMSISLNTYFHDHTGKSINYFATRCQKCRNVVVTRHEENLMKNNLNGENCPFCGYKILYKSPLKKYNISKTFVSKKVEINWLMNIELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZU1</accession>
    <name>H9ZZU1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="7">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="7">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pheS</name>
        <name evidence="9" type="ordered locus">FFONT_0257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="7"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0257"/>
    <dbReference type="EnsemblBacteria" id="AFH42248">
        <property type="protein sequence ID" value="AFH42248"/>
        <property type="gene ID" value="FFONT_0257"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0257"/>
    <dbReference type="eggNOG" id="arCOG00410">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_2_2_2"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00282">
        <property type="entry name" value="Phe_tRNA_synth_alpha2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022917">
        <property type="entry name" value="Phe_tRNA_ligase_alpha_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002831">
        <property type="entry name" value="Tscrpt_reg_TrmB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01978">
        <property type="entry name" value="TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="242"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="499" mass="57997" checksum="441D85294A7CD58B" modified="2012-06-13" version="1">MESKYELSDNEQKVVKFLADKNEVFSIEELASGCNIPISTANAVVELLKSKGLVREEVNYKIQYKLTEEGKKVLEKGFPEEALLDALREKQEIDMKELEKNIDRKILPIALAAGKKRGLIDIKNGKVKLIPEKVEELKKDKEILLKIERSESVEGFKERIEILIKRGLIEKKILKERKIKPEAKKIKEVLEKGESVVSKITSSIIVSGKWREVKFKEYNVEAEPPKVYPGIQHFYSKFIEKIKMILLELGFKEVYGSIIEQEFWNFDVLFQAQDHPSREIHDTFWIDKEVKEIFARKELIEKTREVHEYGGKTGSIGWRYKWDQEVAKRLILRTQTTVVSGRTLSLSPEAPFRFFTIGKVFRPDVIDARHLPEFYQFDAIISEKDMSFSKFLGMLKLFFKKMGFEELIFKPAYFPFTEPSVEGYVKIGNLGYVEVFGAGMFRPEVLEIFDIKHPVGAWGMGLDRLAMALLNLSDIRMLYDRNLENLRNSYSNALKYLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZU6</accession>
    <name>H9ZZU6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RHH_1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42253">
        <property type="protein sequence ID" value="AFH42253"/>
        <property type="gene ID" value="FFONT_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0263"/>
    <dbReference type="eggNOG" id="arCOG03846">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206914_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="4"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="58" mass="6764" checksum="12BC78CEA8739B9C" modified="2012-06-13" version="1">MKIITFKLDEELLERIDMLAQESGTNRSDIIRKAIIMYLSKAEKESAVKKPRIKIIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZU8</accession>
    <name>H9ZZU8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
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                <person name="Perevalova A.A."/>
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</entry>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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        </source>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="447" mass="48938" checksum="1DE08B4E81BEA5C1" modified="2012-06-13" version="1">MADSHGLKRQVGWFVSASLVLGTLGSNGLFGNYPVTYRIAGPAASFVWIVTMIFGGFLAMTLAYDFTIWPDKAGSEYAPVRIALGKYLGGLTAWGFYVSWGTAATIGTLITGWYIWPTNTTYQTIFTGVTVTVFFIINYFGIKLAGLAEVIMTLLRIVPTIFVGLVAIPYVNLSNFHPFWVASSEIPGASANSLYGMFMLFLAASLYSTWSTYATDIFASIVPEIKDPEKNVPRAGLASTLIPLLFVSLITITGIGVLGSDLGTGEAPLFEYSRIVLGGVGLALMWTALISGTLTNANVAMIGGSRVLYQMAVEGDIPKIFAKTNKYGVPIIGLIFTYIINIAMLLYTPIYAILVAMFQVPYMLTIFLLSVANLKIRATKEWHEKAAWKAPWWLIIGFFIIGVLSLMYCWAYGILFGWHDIILGAASEVVMLVLLAIPDIMKRREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I0A044</accession>
    <name>I0A044_FERFK</name>
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        <submittedName>
            <fullName evidence="5">AAA family ATPase-domain containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="5" type="ordered locus">FFONT_0361</name>
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48_2" evidence="3">
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            <begin position="111"/>
            <end position="174"/>
        </location>
    </feature>
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            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="489"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="731" mass="82211" checksum="F0618648ECEA59ED" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A058</accession>
    <name>I0A058_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Binding-protein-dependent transport systems inner membrane component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
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            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccales</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0375"/>
    <dbReference type="EnsemblBacteria" id="AFH42365">
        <property type="protein sequence ID" value="AFH42365"/>
        <property type="gene ID" value="FFONT_0375"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0375"/>
    <dbReference type="eggNOG" id="arCOG00174">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036171_2_0_2"/>
    <dbReference type="OMA" id="FGTQWYI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="167"/>
        </location>
    </feature>
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            <end position="208"/>
        </location>
    </feature>
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    </feature>
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        <location>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
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            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
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            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="317"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="528" mass="59371" checksum="DEEB743C46D5ADB8" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I0A059</accession>
    <name>I0A059_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CTP synthase</fullName>
            <ecNumber evidence="9">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="9">CTP synthetase</shortName>
            <shortName evidence="9">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pyrG</name>
        <name evidence="12" type="ordered locus">FFONT_0376</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="9">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="9"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0376"/>
    <dbReference type="MEROPS" id="C26.964"/>
    <dbReference type="EnsemblBacteria" id="AFH42366">
        <property type="protein sequence ID" value="AFH42366"/>
        <property type="gene ID" value="FFONT_0376"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0376"/>
    <dbReference type="eggNOG" id="arCOG00063">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_2"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP_synth_N" evidence="11">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="GATase" evidence="10">
        <location>
            <begin position="291"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="9">
        <location>
            <begin position="1"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="L-glutamine binding" evidence="9">
        <location>
            <begin position="373"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="9">
        <location>
            <position position="372"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="3"/>
            <end position="8"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="177"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH42366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="520" mass="58836" checksum="7566AB384E07E1BC" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0A6</accession>
    <name>I0A0A6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase (NDP forming), alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0423"/>
    <dbReference type="EnsemblBacteria" id="AFH42413">
        <property type="protein sequence ID" value="AFH42413"/>
        <property type="gene ID" value="FFONT_0423"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0423"/>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_2_3_2"/>
    <dbReference type="OMA" id="CVPPIFI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="476" mass="51770" checksum="80AB90E864D1AD50" modified="2012-06-13" version="1">MQSDLKYFFYPSSVAIIGASEDPLKIGGLVFRNVISGYKGKVFPINPKHNMLNGYKVYRSILDVPDEVDLAIVVIPAAGVLSAIEEACKKKVKASIIITSGFAETGEQGRKLQEQVIARAKSCGMRVIGPNSFGIVSTAVDLNATFGVGIRRKGSTAFISQSGAIADGTFDWFQDEGIGFSILVNLGNRGDVNEAEIIGFLKEDETTNTIGIYLEGLPNGLGREFLKAVEETISEKPIVVLKSGRSSSGARGAMSHTGSLAGSYNIYKTAIQQHHAFVVESMQDLIDYIRALSMQKNRTTNSEIRGIGILSNSGGLGILAADEAEKVGFNVPMLPQNVIDEIRKIIPPYGAPYNPIDVTAQGTPKQQYEFYSKTFKVLEEHNVVDGYVVIIEGSFPRETVEAITDAIINEIVPITKKPIVVNWYAAKSIIEDLAKKIENEKVPVYPTPERAIHGLQALINYSLARKKAQIKALISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0A7</accession>
    <name>I0A0A7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Indolepyruvate:ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0424"/>
    <dbReference type="EnsemblBacteria" id="AFH42414">
        <property type="protein sequence ID" value="AFH42414"/>
        <property type="gene ID" value="FFONT_0424"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0424"/>
    <dbReference type="eggNOG" id="arCOG01602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_1_1_2"/>
    <dbReference type="OMA" id="IGMSQRG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="204" mass="22347" checksum="F19FCA29EE319FD5" modified="2012-06-13" version="1">MSNETKQVIVTGIGGQGNVLMARILVAAAIDSGLEGRVGELYGSAQRGGPVASHVKFGKKAFSPIILEHEADAIISLELSESLRRLNMLKPNGAILINDYRIIPSSVMLGESKYPTKEEVIEAIKKVTDKICIIPATDMAKQLGNARIANVLMLGAFRVFFDTGIDREYFIQAIKENVRPKYVELNIKAFEKGEELGRELCKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0C1</accession>
    <name>I0A0C1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0438"/>
    <dbReference type="EnsemblBacteria" id="AFH42428">
        <property type="protein sequence ID" value="AFH42428"/>
        <property type="gene ID" value="FFONT_0438"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0438"/>
    <dbReference type="eggNOG" id="arCOG00666">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_0_1_2"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Bifunctiontional_GlmU_arc-type"/>
    </dbReference>
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        <property type="entry name" value="NTP_transferase_dom"/>
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        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03992">
        <property type="entry name" value="Arch_glmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="427" mass="47181" checksum="3186E3A3148C6311" modified="2012-06-13" version="1">MSKNITAVILAAGKGERMWPLTYDTPKPLLPILCKPLLNIHLNALEEADLLNSAIVLTYKNKEKIFEYLNGYNNLTGKKIKLMEQSLPLGTGHAIKEILEGAEDLGDEILVVYGDIFVPSKEMSRILKNILEFDGNIIAVKEVNNLSKYGLVKVDEHGNLLEIQEKRKDIPPDVNGYVNAGIMKLRIGDLKKYIDKTEISPRGEIELTSVLNLIAKNNSVKIYPIESSWMDVGTPWDLLKANIIELDHYCSELGKNPEDCLIYDKSTVEIIEPVSLEGPIYISGKAEIGPCSHLREHTILCGENKIGFSVQIKSSIIMRGAKIPHLNYVGDSVIGEYVNLGAGTVTANLRHDGKNVKSLVKGEYIDTGMRKLGAIVGNYTKTGINTSILPGIKIGANTWINAGCIIDRDVPDDAIVYCSQEKKIKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0E1</accession>
    <name>I0A0E1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein FFONT_0458</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0458"/>
    <dbReference type="EnsemblBacteria" id="AFH42448">
        <property type="protein sequence ID" value="AFH42448"/>
        <property type="gene ID" value="FFONT_0458"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0458"/>
    <dbReference type="eggNOG" id="arCOG01728">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_2_0_2"/>
    <dbReference type="OMA" id="EQEAQYG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="287" mass="32591" checksum="F738D7CB0B01BD13" modified="2012-06-13" version="1">MSGDLVRDPVVAGEFYELRKEKLLEQIRWAFLHPIGPGKEAIFSNSITKNNFGYIAPHAGYIYSGPVAAHTYYNISLEKKPDTFIIIGPNHTGLGAQVSLAPWKQWRTPLGLINVDIELRDYLITKSKVLVPDYNAHLYEHSIEVQLPFLQYIFQKDFQILPIVLMRQTPKVVEKIAEELLDATEHLGRDFTIIASSDMSHYEPYDVAKRKDLKAFEMIKKRDINLFYNYLETENVSMCGPGGVMILMTISKMKNGREPEILKYATSGDLTGDKDAVVGYLSAKFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0F2</accession>
    <name>I0A0F2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Metalloexopeptidase, family M42</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FFONT_0469</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0469"/>
    <dbReference type="EnsemblBacteria" id="AFH42459">
        <property type="protein sequence ID" value="AFH42459"/>
        <property type="gene ID" value="FFONT_0469"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0469"/>
    <dbReference type="eggNOG" id="arCOG01518">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_2"/>
    <dbReference type="OMA" id="FGWPAIH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="367" mass="40418" checksum="ADD74D1F9F5CE0EB" modified="2012-06-13" version="1">MQNFNKDEYKKCLRKYSQANGPSGMEDEVRDLLIEDLKPYADRIWIDSMGNVISLKKGVSGKKLMIAAHMDEISLIVKYIDDNGFLRFSPVGGWSERILPATRVKVRTNKGDWIPGVIGVKPPHLITPEEEKKVIEMNKLFIDVGASSRQEALSMGIEHGSRVLLDYDFADLIGNRVTGKAFDDRAGLVVALKTFMEVEPNDIDLYFVATVQEEVGLKGARTSAYQISPDVAIALDVTTANDVPDVDEQDQVAKLGKGPAIKIIDGRSGSGLITNTAVLEKMISVAKERGIPYQAEVLTGGTTDSSAIQLTKEGVPAGTISIPARYIHSPVEVIDLVDIHYSVELLKAFYESLKPEWIDSIKEKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0H4</accession>
    <name>I0A0H4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">H/ACA RNA-protein complex component Cbf5p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0491</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0491"/>
    <dbReference type="EnsemblBacteria" id="AFH42481">
        <property type="protein sequence ID" value="AFH42481"/>
        <property type="gene ID" value="FFONT_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0491"/>
    <dbReference type="eggNOG" id="arCOG00987">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_3_0_2"/>
    <dbReference type="OMA" id="KICHDMG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="PTHR23127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TruB_N" evidence="2">
        <location>
            <begin position="18"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="TruB_C_2" evidence="3">
        <location>
            <begin position="82"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="236" mass="26996" checksum="D046C194F522AED2" modified="2012-06-13" version="1">MPYVVHSVKEYVCVMELHDEVNNEELKRVIEMFKGRIYQRPPVRSNVKRRIRIRKIHDIELLERKGNHVLMRIKCDAGTYMRKLCHDIGLLLGVGAHMRELRRTVSGPFTEDHAVRMQELSEAIYLWKNYGNDSALRKMILPVELSTCILPKILVKDSAISSLLYGAPLAKGGVAAYSEDLQTNKIAAVFTSKIELIGIYEILNNPKKNKNGKVVGRPLAVIMERNSYPKNWGKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0K4</accession>
    <name>I0A0K4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rpl23</name>
        <name evidence="8" type="ordered locus">FFONT_0521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 50S ribosomal subunit. Contacts protein L29.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0521"/>
    <dbReference type="EnsemblBacteria" id="AFH42511">
        <property type="protein sequence ID" value="AFH42511"/>
        <property type="gene ID" value="FFONT_0521"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0521"/>
    <dbReference type="eggNOG" id="arCOG04072">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_4_2_2"/>
    <dbReference type="OMA" id="MDPYKVI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_L23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019985">
        <property type="entry name" value="Ribosomal_L23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03636">
        <property type="entry name" value="uL23_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="86" mass="10009" checksum="EDB9847D94DB5F88" modified="2012-06-13" version="1">MSEEFVIISPLHTELALNYIEKYNTIVFVVDRKATKLRIKEEVEKRFGVKVEKVRTEITPKGEKRAFVKLTPEYKAEEVATRLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0L5</accession>
    <name>I0A0L5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1616 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0532"/>
    <dbReference type="EnsemblBacteria" id="AFH42522">
        <property type="protein sequence ID" value="AFH42522"/>
        <property type="gene ID" value="FFONT_0532"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0532"/>
    <dbReference type="eggNOG" id="arCOG02884">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134835_0_0_2"/>
    <dbReference type="OMA" id="ALVFELW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011674">
        <property type="entry name" value="DUF1616"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07760">
        <property type="entry name" value="DUF1616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1616" evidence="2">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="172" mass="19199" checksum="A6F736694243C7EC" modified="2012-06-13" version="1">MVGEEKMSFIMDEEVFAVILAIIVVGSVLGVAMIIRPSSEEPFTALGLLDQNCQIGSYPSTVVNGTNVNLCLFVYNHMGHPIYYEVVYKIGNNLTIPTNTTPSSSLAIKNWRGVLNNDDNETFHVSVPVYANNNETSVALIFELWIYNLTTNEWQYTGIWNHLYVNITFPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0M3</accession>
    <name>I0A0M3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0540"/>
    <dbReference type="EnsemblBacteria" id="AFH42530">
        <property type="protein sequence ID" value="AFH42530"/>
        <property type="gene ID" value="FFONT_0540"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0540"/>
    <dbReference type="eggNOG" id="arCOG04189">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182708_0_0_2"/>
    <dbReference type="OMA" id="YGWLVFF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="102" mass="11361" checksum="585E50064E397CF3" modified="2012-06-13" version="1">MSKDKYIGILLISVSAIVIVLYGYILFLTSYSGILIELTAFIAILGIFGIVGWIGYTLATTPPPKPIEEIEKEIDEELKKLEQEQNVEQKTRSEGNAQGEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0P0</accession>
    <name>I0A0P0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidophosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0557"/>
    <dbReference type="EnsemblBacteria" id="AFH42547">
        <property type="protein sequence ID" value="AFH42547"/>
        <property type="gene ID" value="FFONT_0557"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0557"/>
    <dbReference type="eggNOG" id="arCOG00094">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_0_2"/>
    <dbReference type="OMA" id="CPYGVKM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="423" mass="47652" checksum="F2A63D6BBA2158D2" modified="2012-06-13" version="1">MYLEMPLGFLGLVAFENDWDIFPYASYGLLALQHRGGERQIICGDFKGSLKCMNLNEYESDKNEIKMSFIAATMNGTSGSIEEVQLDGEKIIAISEYERDTLRDLLSEIIKLKDEKVTKLKKLIDEYSEHEVPSFMAITNRNEVIVWRSPNGITPLSIGNYGFDMVLFSSETSAIDVLDCDFRKHLIPGEVAYASPKIFKIFKGKNSKEKGSICLFELLYTARHDSIIDGVPVYDFRKELGKELALNFSHDVDIVVGVPETAYPYAIGFSQAIRKPFELSFIPTAGRMRSMLKASGIERLIAVHLKMNPVKSAMEGKRIALIDDSMVTGSTIKTVSQILRNRVGVEEIHLLIASPKIVSSCPYRIFPLEERNLIASNLEDTNITRYLDVDSLTWLSNESVKKVADKYGISFCDRCFNKNSEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0P2</accession>
    <name>I0A0P2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formate-dependent phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="3">6.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5'-phosphoribosylglycinamide transformylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Formate-dependent GAR transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">GAR transformylase 2</fullName>
            <shortName evidence="3">GART 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Non-folate glycinamide ribonucleotide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphoribosylglycinamide formyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purT</name>
        <name evidence="6" type="ordered locus">FFONT_0559</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24829"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PurK/PurT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.21" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0559"/>
    <dbReference type="EnsemblBacteria" id="AFH42549">
        <property type="protein sequence ID" value="AFH42549"/>
        <property type="gene ID" value="FFONT_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0559"/>
    <dbReference type="eggNOG" id="arCOG01598">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_1_3_2"/>
    <dbReference type="OMA" id="GMVTMIT"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043815">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase 2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01643">
        <property type="entry name" value="PurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005862">
        <property type="entry name" value="PurT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="120"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="3">
        <location>
            <begin position="374"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="404" mass="45023" checksum="6E97A425A914CDA9" modified="2012-06-13" version="1">MRNSLPLTTLSKPIKVMLLGSGELGKEISIEAQRLGAETIAVDRYDFAPAMHVSSKRYIVDMMNKEAIKALAYRERPDVIIPEVEAISFEALEELEDEGFEVIPNSDAVRIAMNRIELRNVASVQLNLPTTRYFVAENEEEAIEGCEKVGYPCIIKPEMSSSGHGHFKIKEGSKEEIRKGYTYAIGHARGKSKRVIVEEFVELETELTVLVYRYESESGGISTETCEPVEHWRYGKYHYIESWQPSVKDKNILASAKSIAIKVANRLGGKGIFGVELFLTKDGRVLFSEVAPRPHDTGMVTMVTQDFNEFAIHVRAALGLPVPKVDIISPGASLAIYSSLENSWSSVIEGVYSALSIPGVGLRIFGKPFSYKDRRMALLLARGKNTEEALEKVRKASSFLKIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Q1</accession>
    <name>I0A0Q1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase</fullName>
            <ecNumber evidence="3">6.3.4.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">purP</name>
        <name evidence="6" type="ordered locus">FFONT_0568</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24836"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.23" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0568"/>
    <dbReference type="EnsemblBacteria" id="AFH42558">
        <property type="protein sequence ID" value="AFH42558"/>
        <property type="gene ID" value="FFONT_0568"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0568"/>
    <dbReference type="eggNOG" id="arCOG04346">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065084_0_0_2"/>
    <dbReference type="OMA" id="CIHYFYS"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00134"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01163">
        <property type="entry name" value="IMP_biosynth_PurP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023656">
        <property type="entry name" value="IMP_biosynth_PurP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009720">
        <property type="entry name" value="IMP_biosynth_PurP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010672">
        <property type="entry name" value="IMP_biosynth_PurP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38147">
        <property type="entry name" value="PTHR38147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06849">
        <property type="entry name" value="DUF1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06973">
        <property type="entry name" value="DUF1297"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004602">
        <property type="entry name" value="ATPgrasp_PurP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="5">
        <location>
            <begin position="125"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</name>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</name>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</name>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="355" mass="40386" checksum="C90A01CF4EBFF3BC" modified="2012-06-13" version="1">MSVKSLIEKYDLENLTIATLASHSSLQIVHGAKKEGFKTALITLHDREHFYRNFENLIDHLIVVNSWNEICTEKVEKKLESLNSIFVPHGSLVEYVGIKCAESFKIPYFGTRKMFRIEADQYKKMSLLYQAGIPIPKEYSLEDDIEKPVIVKLPGAKGGKGYFIATSKKDIKEKLSDLKKSGIIDDEKNVIIQEYVIGTPAYFHYFYSPIKNRIEILGADIRYESNIDGLKRLPSEFGITNFIEPSFVVVGNLPMVLRESLLPKVLDYGERFVKASKTEAQPGIIGPFSIETIIRDDLEIIAFEFSGRIVAGTNLYISGSPYSWLYFNEEMSMGRRIAREIKMAKENNSLELVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Q8</accession>
    <name>I0A0Q8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0575"/>
    <dbReference type="EnsemblBacteria" id="AFH42565">
        <property type="protein sequence ID" value="AFH42565"/>
        <property type="gene ID" value="FFONT_0575"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0575"/>
    <dbReference type="eggNOG" id="arCOG03871">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2327154_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="98" mass="10997" checksum="5988A09AF2CD58BE" modified="2012-06-13" version="1">MSEQIRIEGVSIKLSENKPGIYKITIFIKNVGEVKADINSAYVFNIYGNVFCSEILNISLQPGEVNTISLECKLEERAPYFAKVATKKGQESLYSFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0S7</accession>
    <name>I0A0S7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps7</name>
        <name evidence="9" type="ordered locus">FFONT_0594</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5 7">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0594"/>
    <dbReference type="EnsemblBacteria" id="AFH42584">
        <property type="protein sequence ID" value="AFH42584"/>
        <property type="gene ID" value="FFONT_0594"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0594"/>
    <dbReference type="eggNOG" id="arCOG04254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063975_0_0_2"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_A">
        <property type="entry name" value="Ribosomal_S7_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_S5/S7_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026018">
        <property type="entry name" value="Ribosomal_S7_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_S7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_S7" evidence="8">
        <location>
            <begin position="60"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="200" mass="22809" checksum="BE7F03F048FF3EB5" modified="2012-06-13" version="1">MVIVLAENEEIKAVEIKLFDKWSYEGIEIRDPSLKKYISLRPVFLPHTGGRHEHVRFGKSRIPIVERLINNLMKHGRNMGKKHLAYNIVKNAFEIIYLQTKQNPLQVLVRAIENAAPREETTRIMYGGIIYHVAVDVAPQRRVDLALRNITDGARNCAFNGPKPIEECLADEIIAVANNDPKSYSIAKKEEVERIALSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0T2</accession>
    <name>I0A0T2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L30e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl30e</name>
        <name evidence="7" type="ordered locus">FFONT_0599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0599"/>
    <dbReference type="EnsemblBacteria" id="AFH42589">
        <property type="protein sequence ID" value="AFH42589"/>
        <property type="gene ID" value="FFONT_0599"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0599"/>
    <dbReference type="eggNOG" id="arCOG01752">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130502_1_0_2"/>
    <dbReference type="OMA" id="RPHKIMA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00481">
        <property type="entry name" value="Ribosomal_L30e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="L30/L30e/YlxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000231">
        <property type="entry name" value="Ribosomal_L30e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_L30e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="PTHR11449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449:SF1">
        <property type="entry name" value="PTHR11449:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="6">
        <location>
            <begin position="4"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="91" mass="9879" checksum="F0711F83F949F532" modified="2012-06-13" version="1">MVIRTGKLEIGSQSTIKTLKHGKSKMVVIASNADPSVKKDIEYYAKLSQTPIYVFQGTSVELGTLLGKPFPIQALSIIDVGDSKILELVET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0U9</accession>
    <name>I0A0U9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nitro_FeMo-Co domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0616</name>
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
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</entry>
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                <person name="Mardanov A.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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</entry>
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    <accession>I0A124</accession>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Bidzhieva S.Kh."/>
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        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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    </evidence>
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    <sequence length="198" mass="22239" checksum="6ED8AF6DF37EFAC9" modified="2012-06-13" version="1">MRASSELISTVILIAAVLAMSSGLWYYAQDFSSNLSNNQYISSEISQSAMSLNLLKVYSDPSSSNLVYQVGYVQGSTIYLAVLTIQKNSFIYLGQEQISEPSQGLGFFNLSDPSEWTSLPVIQVQSSQVMVQPIYSSDSSYYPLSLWLGSNGINLYPLYFNTSSVQLLNIKVNSNYDNVMVFFTYLNGKYWAFSYFYV</sequence>
</entry>
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    <accession>I0A133</accession>
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                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH42723">
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42723.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="376" mass="42260" checksum="1218B1D800FBC5BE" modified="2012-06-13" version="1">MRKISSSIYERDIFLKKLKKIEEIAQEKGISKIVLMNDTNIRYLTGLELSGAAILDFVNKEHTIIIPFMENWKIKKLFGGYFRVIGVTRYDFGLEEGVEKFIGSINEAVAKFLIESDKIGIDLDLNKSSDSNIKSKVKSVVQINDEMIRVRRTKLPEEIDLIKKAVEITEKALSQTIENLRNGMREKEIYSEHICQLYKSGAEYLAFDPIVAITENASNPHAISGNRELKADDILLIDTGAKFGGYASDMTRTIIPEKGEFKKYIELLEEAYFSSLDALKTGAGAKEIDGIARNILKKYGLEKYFIHSLGHGVGIDVHEAPNIGPTSNEVFMENEVVAIEPGIYFPEKIGFRLENTVIVGKNGAIPLNSLEFVIQR</sequence>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AFH42749">
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="133" mass="14927" checksum="3A355046560FEA16" modified="2012-06-13" version="1">MVQISTERISAEKVSEIPPPMMRYNTQLNVTKISEDPHTGIGAYEFRISLLSDPMVVNIVITGKVRIQAQNQDEIKEIFTKKSNEERANFVAGLVLPHLMGTLILISRELQVPPPLPMAPPPPQKTKEDFHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1D1</accession>
    <name>I0A1D1_FERFK</name>
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        <submittedName>
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    <organism evidence="11 12">
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            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
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    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_0800"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0800"/>
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        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_013350_3_0_2"/>
    <dbReference type="OMA" id="PLGYDWK"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:GTP binding"/>
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        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fe2_transport_prot-B"/>
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        <property type="entry name" value="Fe2_transport_prot_B_C"/>
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        <property type="entry name" value="G_FEOB_dom"/>
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    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
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    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
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    <dbReference type="Pfam" id="PF07664">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17910">
        <property type="entry name" value="FeoB_Cyto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07670">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="9">
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="AFH42788.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="710" mass="78825" checksum="2B82271F019B006C" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1F2</accession>
    <name>I0A1F2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NMD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0821"/>
    <dbReference type="EnsemblBacteria" id="AFH42809">
        <property type="protein sequence ID" value="AFH42809"/>
        <property type="gene ID" value="FFONT_0821"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0821"/>
    <dbReference type="eggNOG" id="arCOG04149">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065087_1_1_2"/>
    <dbReference type="OMA" id="NYEVAGM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMD3" evidence="2">
        <location>
            <begin position="5"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="336" mass="38849" checksum="027A2CC52E232AE5" modified="2012-06-13" version="1">MRKICPICGREESKNLPFVGGICVECYLNKNPLEIKAITLNKCKICGKIRYKNDWIFANENFYSEIFAKEVEKNNKKKFIQFGLDLKAVPYKEKVLVTVQNEIGKYETYLDPIIDYKFTICPQCLARKAGSYDSVIQIRGTNKLDFEDKKIIMNLIEKLPYDLKQHIVTITENKDWIDVEIVGHEKARLIASFLSEKLGGETKQTFKLISTKKGERNSRLTISLRIDKRREVGEIVEHQGSPAVIIERTSRFLKLFKLKERKEIKLDLKEIRKNVKTFEGEIKSVTVQAVLPDRVIVIDDSYNVDNISFQNVYGEPSKGEKGRIVFTENDLFLVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1I0</accession>
    <name>I0A1I0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AIR synthase related protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0849"/>
    <dbReference type="EnsemblBacteria" id="AFH42837">
        <property type="protein sequence ID" value="AFH42837"/>
        <property type="gene ID" value="FFONT_0849"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0849"/>
    <dbReference type="eggNOG" id="arCOG00636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041631_0_0_2"/>
    <dbReference type="OMA" id="TINDLAC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="42"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="151"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="337" mass="36097" checksum="8A1BDB6C89A682D9" modified="2012-06-13" version="1">MSGKLPISALEKIVLSYTGIKDNRVLVGAKVGEDASIIDIGNEKVIVTHVDPITSAIDSIGWLSIHVVANDIVSSGARPRWFLTVLLLPVGTSYDDIIKIMSGINEALKEINGTLVGGHTEFTDSVNRSVIITTAIGEASKNQVRLTGMAQPGDYIIMTKYAALEATALAALDHGDLLVKSGVSSDEINFAKSLIRKISVYKEAMLLSENGLANSMHDPTEGGIIASSFEMAYASRNDVRIYLDKIPVLPLTFKILKIIGADPLTSLSSGSLLATVPKEKANEAIGLLKDNGIECTIIGEVLKGGGKLRIVKKSSEEVIIDDIPQDSYINAIERRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1J7</accession>
    <name>I0A1J7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Xanthine/uracil/vitamin C permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0866"/>
    <dbReference type="EnsemblBacteria" id="AFH42854">
        <property type="protein sequence ID" value="AFH42854"/>
        <property type="gene ID" value="FFONT_0866"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0866"/>
    <dbReference type="eggNOG" id="arCOG02807">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_0_1_2"/>
    <dbReference type="OMA" id="RKGSYFF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="496" mass="52875" checksum="C78FE17488D142CC" modified="2012-06-13" version="1">MRGLSFKDALYKYFELKERNTTAKVEIIAGITTFLSMAYILFVNPSILTDGFTIALHQALGIPMTQPIPQEYMPLVYNVKLGFTLATALSAATATLIMSLYAKMPFGLAPGMGENAFIGYTAIPLFASILITSHDLQGVAPAIFAIYLALVSVFFNGILFLIFSVGRIREFILNSVPESIRLGISIGIGLFITLIGFSNIGIVEPGVGTPISFNTAALKTAAFYLGLLSFFIAAVLMAKKVIGGFIIAILGSTAIAILLSITGLTPGLISTSSSLFTMPSFTTSILNDLPKSFYLYFTLFGLGFPIAFSLFLVDFFDGIGTLTGLAMKAGLVKDGKVMNINKALISDALASIISPFYGTSTTVVYVESASGIEAGGKSGLTSLIIAILFFISAIFAPLFTYIPTFTTGGVLVLVGLLFLGLAGKLTSMEDLTEVIPAFFTLVAIPFTYSITTGIGFGFISYIVIKIASGKFKDVKPGIVLIALLFIIYFWLAARGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1K3</accession>
    <name>I0A1K3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0872</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0872"/>
    <dbReference type="EnsemblBacteria" id="AFH42860">
        <property type="protein sequence ID" value="AFH42860"/>
        <property type="gene ID" value="FFONT_0872"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0872"/>
    <dbReference type="eggNOG" id="arCOG01290">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015525_2_2_2"/>
    <dbReference type="OMA" id="CYARLYT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040086">
        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01084">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="30"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="271" mass="30840" checksum="9AFEA75B965634B9" modified="2012-06-13" version="1">MKVGNTEVHFIEVKSAISQSGLPDLDYALNPYLGCSHGCIYCYARLYTKDERASKNWGKVVLVKTNLVEVLKKEVKRKKKGIVGVGTITDAYQPLEAIYKLTRRSVKILLESGFYLSFQTKNPLILRDKEILLNYREKVDVGFTITSLKSSVSKFIEPNAPFPISRANAIRALSKEGIKTWIFYGPIIPRINDDRETADAIVTLAVETGSTLFYDSLHIKSFMLNDTYPLNEIIRTFDKARVKNFLNFLKKRCEEEGIICKGGFEEEKKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1M5</accession>
    <name>I0A1M5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0894"/>
    <dbReference type="EnsemblBacteria" id="AFH42882">
        <property type="protein sequence ID" value="AFH42882"/>
        <property type="gene ID" value="FFONT_0894"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0894"/>
    <dbReference type="HOGENOM" id="CLU_1754614_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="148" mass="17133" checksum="7F60EC7FC3B59D9D" modified="2012-06-13" version="1">MKIALKKIIKSITIGLIYSALLIILILTIQFFINTISFPILKEISPLFYFNLRNYIPYVVLFLFLSTASEILEGTVYSFIVKAISKIIVLMIIFTSFNNGFISYSITQGNSIVNIEINFNPLLYLFFAIFITFILLDFFSMINFYDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1P5</accession>
    <name>I0A1P5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42902">
        <property type="protein sequence ID" value="AFH42902"/>
        <property type="gene ID" value="FFONT_0914"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0914"/>
    <dbReference type="eggNOG" id="arCOG01688">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044290_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="266" mass="30412" checksum="39327BAC755F7F47" modified="2012-06-13" version="1">MERYPINGLFAYSAPIGTNVSCIDVLIRENMANNTNKTIAKILQEVVLMGLPILDMKYSLSEDGEAGIMFLVLASGEDQAKMLIERINGFSSNIKASLGRKYKRTCYSNIAFPVKFSGSRWIYMGPANLDGILFDLKKILGKQVESYILRQLGRYIGKNIYEYYTESLGHIDSLEETIRFLSMLFQISSWGIIEEYEISENRIMLIIRDLWEVVVLKEKQSSDKPKLTLGVIEGFYSSLTKRDIRSEVALVKKEEGVYKTEIQVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1S6</accession>
    <name>I0A1S6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Peptide chain release factor subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Translation termination factor aRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prf1</name>
        <name evidence="11" type="ordered locus">FFONT_0945</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0945"/>
    <dbReference type="EnsemblBacteria" id="AFH42933">
        <property type="protein sequence ID" value="AFH42933"/>
        <property type="gene ID" value="FFONT_0945"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0945"/>
    <dbReference type="eggNOG" id="arCOG01742">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035759_3_0_2"/>
    <dbReference type="OMA" id="GQEMEVV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <sequence length="378" mass="42927" checksum="D04088A03C375BFC" modified="2012-06-13" version="1">MFKSSRLKLVPEVSSSYLISKEHLKAIVKELKQWVAPATTLLSLYIPPGRPISDVVNMLREELSITDNIKLKRTKDAVQTSLSMAIDRLSSINKVPENGLVLFCGKNSDTNKEICLMFSPPEPVKIYFYRTDKWFHVEYLEDMISEKDYYGLILIERDEATIGLLKGTTIQMLDNFMSYIPGKHTKGGQSQRRFDRIIEQMVEDFYKTVAERAKQLFEPLLLEGKLKGILIGGPGYSKQDFVTGEYLEKRFRDLVINKLIDVGYQGEAGLRELVLKAEDVLQDHRYSDIVKKAEELKLHMAKADGLYVFGIEEVKHAAEIGALQTLLIIESHPNIDEMEAVAKKSNAEIVIVPEDTPEGEWLKSSFGGVAGILRYKLY</sequence>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="209" mass="24619" checksum="5CA81222E9A22EE9" modified="2012-06-13" version="1">MSFDKRSTLPTKINLIKLKRDLTLIRRVREVLEEKRSALLLYLNTMIKEYEKLYNETSSELKKAYDTLQASLLTIGYNRSKEISDIVPSTLRVNVKIRALFAVKVPYISIAENSFPKMDFPSDVPPSLIESREKLKEVFEKLLRLIEVENTLFTIINELKTTQRLINSIDYSIIPNYEKTIRYISLVLDEREREEFSRLKMIKKIHEEA</sequence>
</entry>
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    <accession>I0A1V1</accession>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="gene ID" value="FFONT_0970"/>
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    </dbReference>
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            <dbReference type="EMBL" id="AFH42958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="44" mass="4965" checksum="8039DF5B01E4AC2D" modified="2012-06-13" version="1">MRGGLYPFSIWGGSEILSNALQMKDVFTNRYEEPMNSLRGTLAL</sequence>
</entry>
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    <accession>I0A1X1</accession>
    <name>I0A1X1_FERFK</name>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="gene ID" value="FFONT_0990"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UPF0020" evidence="1">
        <location>
            <begin position="160"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="336" mass="37894" checksum="0DECF78BB67DA502" modified="2012-06-13" version="1">MPLFYALLSGKYPCLSRSEFISLLEFYEGNIVLELTNTTIFEVEDETDAINIQVRSSTIKEVGRVIGIIPSKGEPLFFKYCPNGKIYIKPHRIQGFLKSLDGNALVSIALSFIKKNCIESRKEDKKTVRVIAADGVLIIGELLSDRGKGDIISQNPHNLPFYKPGALNFWFARLLVNLSISKEGRVFYDPFCGTGSLPLSALNDWEFISICSDIRKDMCYGAKRNLKTLSKVNEFEIIRADARHLPIRERSIGFVATDPPYGRSVKSLFSDSTNLSQDSLKELANILDFGGKIVFSLDRNIAEKLIIPEGLKIKSRCPMYVHNRLTRIIMVMQKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1X9</accession>
    <name>I0A1X9_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">FFONT_0998</name>
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    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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            <taxon>Archaea</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0998"/>
    <dbReference type="EnsemblBacteria" id="AFH42986">
        <property type="protein sequence ID" value="AFH42986"/>
        <property type="gene ID" value="FFONT_0998"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0998"/>
    <dbReference type="HOGENOM" id="CLU_2490301_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="86" mass="10137" checksum="1ACB42868116BDD1" modified="2012-06-13" version="1">MFFKPRFFKFSFLFGKFQILLITPITSESLVIYGGKNQVSYLTEGCDKVFNLKKQIAKDFILKIVLKMVGYMNHIKYDVNMEKLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A207</accession>
    <name>I0A207_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">FFONT_1026</name>
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    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1026"/>
    <dbReference type="EnsemblBacteria" id="AFH43014">
        <property type="protein sequence ID" value="AFH43014"/>
        <property type="gene ID" value="FFONT_1026"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1026"/>
    <dbReference type="eggNOG" id="arCOG00993">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1507326_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="178" mass="20490" checksum="18EC3CAD09445BB4" modified="2012-06-13" version="1">MSDEEKIKLKEIFPCEVGKKKVDVFLKKVFGYGVDKILNDCFIFYCNERKKRKDIFCMSKELENLYARLKENGILPYSIGLFLGSIMNNRYKPSLQLGSEISLKAKKLEKGIIYVKNAKISFGKTISLNEIALIKRNESGIYLVLLQDETFLGWGILKRKILVPLADIGLYLRGFEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A222</accession>
    <name>I0A222_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="5 9">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FFONT_1041</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + NAD(+) = 2-dehydropantoate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:61292"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="1">
            <dbReference type="Rhea" id="RHEA:61294"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="2">
            <dbReference type="Rhea" id="RHEA:16235"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="5 9"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1041"/>
    <dbReference type="EnsemblBacteria" id="AFH43029">
        <property type="protein sequence ID" value="AFH43029"/>
        <property type="gene ID" value="FFONT_1041"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1041"/>
    <dbReference type="eggNOG" id="arCOG04139">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_0_0_2"/>
    <dbReference type="OMA" id="NYSSMYQ"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="10">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="11">
        <location>
            <begin position="170"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH43029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="299" mass="33362" checksum="4FD3C0F9E9020472" modified="2012-06-13" version="1">MHEHEYCIIGAGNIGILLSYFLRNEDVAIIKKNNSEITYVRLLNGEKSWEQRFVSFEIENNFFCRKALIATKAYNVEEVVSKIKGKAENVFSFQNGLGIIEILVNNFGVKNSFGSSITYGVSSCGKYCTEIKGLGEIIVGQLGKKYDENVLSEFSYAIKKGGGNIEVVDDIMPYLWLKAIINSAINPITTLLGSKNKAVIENDFAQSLALKTIKEGEKVASALGIKLPSDPEKMLFEIATKTGENYSSMLQDIKNKKRTEIDYINGYIALQGEKLSLNVETNKTLYLMVKALEKELFIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A228</accession>
    <name>I0A228_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43035">
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        <property type="gene ID" value="FFONT_1047"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG04324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000007391">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="108" mass="12138" checksum="5007A7F8B9B620B8" modified="2012-06-13" version="1">MEEFKKTVEFEGKAKVGEMLGGLANIQLKPEDFSSPIALQMAISRMYEGILKAFEEGPKKKYIAEVRFTDSLGNQVSIGIDLGENPPPFSKQEVKARIIIELFEENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A251</accession>
    <name>I0A251_FERFK</name>
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            <fullName evidence="1">AcnX domain-containing protein</fullName>
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        <name evidence="2" type="ordered locus">FFONT_1070</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH43058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43058">
        <property type="protein sequence ID" value="AFH43058"/>
        <property type="gene ID" value="FFONT_1070"/>
    </dbReference>
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    <dbReference type="Pfam" id="PF04412">
        <property type="entry name" value="AcnX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AcnX" evidence="1">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="400" mass="43907" checksum="8860003A16A9F847" modified="2012-06-13" version="1">MFLTKEEESILNGAHGEIKALALKTIIKIGESLNAERLVDVSHVHASGLSYLTIGDAGLVFIESVVSKNAKVKVFSTLNPVGMDLDDWKKMGISEDFAEKQKRIVELVLKLGFDPTFTCTPYLIRKPFPGEHLAWGESSAVGMANTYYGAYTNREGGPITILSAIVGKIYEAGLHLKENRVPTVEIIIDGEIDLTDPSISGALGIIVGEKIKSGIPLFKRNRLTSFEAIKSYTAAVGANGDIAMSVIDGITPEYKDLIKKAGELEKVHIDANELKEIVKDSIDYIPDVVLMGCPHADLEEILNFSIQIKDCKKINVPVIISTSRYVSNKLNEMGLLQQLEEKGVIFIKDTCPVVSPFVSLKFKNIVTVSGKSLFYLPRMHDVKVAIVPFNKVGEVVCRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A259</accession>
    <name>I0A259_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43066">
        <property type="protein sequence ID" value="AFH43066"/>
        <property type="gene ID" value="FFONT_1078"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_171553_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="97" mass="11188" checksum="848D329CA6DEA163" modified="2012-06-13" version="1">MEKLINKIKNFFSFIKYFLPEYSKMNAIQSIEKEYSEYLSVFLLLVFGGMIGMPSPPSSVTIRILPMALDELKFLQNKGRRVDDTLGDIIDAINFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A271</accession>
    <name>I0A271_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor IF-2 subunit alpha</fullName>
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    </protein>
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        <name evidence="5" type="ordered locus">FFONT_1090</name>
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    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
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    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1163730.FFONT_1090"/>
    <dbReference type="EnsemblBacteria" id="AFH43078">
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        <property type="gene ID" value="FFONT_1090"/>
    </dbReference>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
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        <property type="entry name" value="S1_domain"/>
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    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
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    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
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        <property type="entry name" value="TIF2_asu_middle_sf"/>
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        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="PTHR10602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <feature type="domain" description="S1 motif" evidence="4">
        <location>
            <begin position="12"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="264" mass="30673" checksum="82EF61C8D5261087" modified="2012-06-13" version="1">MVRARKELPDANELVIATVKEIFDYGAYVELDEYNGMRAFLPWSEVATKWVKNIKEVLKENEKIVVKVIRVNKQKKQVDVSLKRVYDSEKKKKMHWYKRNQRAEKILELAAQKLGKTLDDAYNDIGWPLLDHYSDLYTALETAVMLGPDTLRVPNAKEEWIMPVYEEANKHIKIKQVKVTRIINLWSTSPSGIEDIRSVLLNMKNISEDNSSVNIYTIGAPKYKIEVISEDYKSAERIINSILEKAEKDAQKLKVNFEVVKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2A8</accession>
    <name>I0A2A8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">50S ribosomal protein L15e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl15e</name>
        <name evidence="6" type="ordered locus">FFONT_1127</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1127"/>
    <dbReference type="EnsemblBacteria" id="AFH43115">
        <property type="protein sequence ID" value="AFH43115"/>
        <property type="gene ID" value="FFONT_1127"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1127"/>
    <dbReference type="eggNOG" id="arCOG04209">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080796_1_0_2"/>
    <dbReference type="OMA" id="KYMQELY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00256">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rbsml_L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_L15e"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L15e_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_L15e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="PTHR11847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="235" mass="27573" checksum="18E288DCB41E329F" modified="2012-06-13" version="1">MLFSGMVCIEMSKSMYYYMARVWKRPYSGDHLQLMRARMIRWRREPAVVRINKPTRLNKARMLGYKAKQGIIVVRVRIRKGGQRRQRPNKGRRPKRMGVYGYAPAKSIRLIAEERAARKYPNLEVLNSYYVGEDGVHEWYEVIMVDPHHPAILSDPELKWIAEPQNRGRVFRGLTSAGKKMRGLKASRGLRGTMNYKFKKKQKEREQKRRHEASRGARLIAPAEILEKVHKGDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2A9</accession>
    <name>I0A2A9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1128"/>
    <dbReference type="EnsemblBacteria" id="AFH43116">
        <property type="protein sequence ID" value="AFH43116"/>
        <property type="gene ID" value="FFONT_1128"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1128"/>
    <dbReference type="eggNOG" id="arCOG01042">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131306_1_2_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002739">
        <property type="entry name" value="UPF0201"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01877">
        <property type="entry name" value="RNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="145" mass="16915" checksum="FC4F98B19DBBB70B" modified="2012-06-13" version="1">MSIKQIELRVIQHMTEEEDRVLRSLLNALPEDLREKVKPVAVSSKGHYGDTIIFYKVVLEKEDAEKAAEFIIRSFDKCSVFEIKNTFYNRFSDNSFHLRLDKFKLLENKFIISNSDDVVKIVIKESKKGSIKEIFERAGISIEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2F5</accession>
    <name>I0A2F5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dehydrogenase (Flavoprotein)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1174"/>
    <dbReference type="EnsemblBacteria" id="AFH43162">
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        <property type="gene ID" value="FFONT_1174"/>
    </dbReference>
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    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066799_0_0_2"/>
    <dbReference type="OMA" id="ETAYFIF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="335" mass="38801" checksum="24F5BA2931ED372E" modified="2012-06-13" version="1">MIKIVGGGPSGISFAISYLINSRKDEKIKVYDGERNYEKPCGEALLNLNMNIYYVEPEILHEIKDFYIYDGENLIEERHYSSGKWFIIDKRKWIEEHRRYAEKSGILLSYEKVNPFKEKNGSEDLVIDATGPFSFNKLRKIPIARAIISSDLSLESEVKLIFDAENIGFYWVFPSAGKLINVGYGSLLIKNPTSKLMEFMNKKFRNLRILNIKTSLITLQYRAKPIYTFGYTIGEANGTVFSLTGEGIRPSYVQSSLLGKFLIELRDFNKAYNTVINHADFKELSDQLKLQYNLLTIYQKLPLSMRRSLLRRIKHAIDDYITKNVIDPRKVLFKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2K0</accession>
    <name>I0A2K0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1219</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1219"/>
    <dbReference type="EnsemblBacteria" id="AFH43207">
        <property type="protein sequence ID" value="AFH43207"/>
        <property type="gene ID" value="FFONT_1219"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1219"/>
    <dbReference type="eggNOG" id="arCOG01921">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1820940_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002746">
        <property type="entry name" value="UPF0216"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01886">
        <property type="entry name" value="DUF61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="141" mass="16670" checksum="A3CD96C67BB7FFA6" modified="2012-06-13" version="1">MSQENNIAETLRKKVILDLSAINDPVEEYVRLNEVGNEDVLLKTKSKSFFILKKDDIAKLKENLPSYFHEMLALPIEINILVTPNNKIYMLNEDLWQRRAVRYILNKKLEYEPKKYITNDELNTLISLMPSVFKLKIKVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2L8</accession>
    <name>I0A2L8_FERFK</name>
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        <recommendedName>
            <fullName evidence="1">SO_alpha_A3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1237"/>
    <dbReference type="EnsemblBacteria" id="AFH43225">
        <property type="protein sequence ID" value="AFH43225"/>
        <property type="gene ID" value="FFONT_1237"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1237"/>
    <dbReference type="eggNOG" id="arCOG01299">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564558_0_0_2"/>
    <dbReference type="OMA" id="AMGFCQG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041117">
        <property type="entry name" value="SoxA_A3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17806">
        <property type="entry name" value="SO_alpha_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SO_alpha_A3" evidence="1">
        <location>
            <begin position="422"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="504" mass="56503" checksum="3FFD8B0E20C4BD88" modified="2012-06-13" version="1">MSNEKSFSLFEKETIPVASSPKFKRPRAPFYMESWCPWIRVHAQPVFYLYDPRISQSPSPKIGSSLSTKIRKKLGQAGFYHSFLVRSIWSQAWKKIVSYSENPELPNIDSEYENTEIEEVKKDFLILGDEGDAITFANFLYDEAKGSILMISSKSRKELENESKETLNDSVEFYTGLYLGKFDDGFVFLNKEKKKILKIDAKSFVIYPGFRDSFPIFENNDLPGIIGSSLAIKLLVNKGLLKEIKKVTVLIGNDERGYEVANEISKYKDTTIVDVKNNVKEIKAFGYPKIEGIIVDLPSGIEKINTDLLVSAVSFIPNIEPALQLGGNIVYSSNLNTITVHTKNGEIVGNNNMYFLGQASGTPKNLVKEEAEIAAKLASGKSLSTTESSKLAEIQKEKNLIDPNEVIVKERPVFILTSNTKGMKFVCPCQDVTLEDLIKAFDMGFSNLEEIKRFTALGTGTCQGRICRIAALHALSYFRNVPIGSIGNFRQRAPLVPVEIEYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2M5</accession>
    <name>I0A2M5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1244"/>
    <dbReference type="EnsemblBacteria" id="AFH43232">
        <property type="protein sequence ID" value="AFH43232"/>
        <property type="gene ID" value="FFONT_1244"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1244"/>
    <dbReference type="eggNOG" id="arCOG00600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1088215_0_0_2"/>
    <dbReference type="OMA" id="RVEELMW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="60"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="199"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="255" mass="29090" checksum="AE8B0F9631F1DF60" modified="2012-06-13" version="1">MTFKDAIFGLNFRRIRYPPVIEEDGRYMGLLRLQNIIEKTYEYYEKNTFAELQNIKALELSDNTVPPVTLMKPSIDELIDLMTSHKVGALAVVNKNEEVIGEITEKNLIDTIDIRKPFGILIGDIISGKEIIKVEATDILISAVELMRKHKVKRLPVVFQGELIGIITIRDVLKYFALQLRSYGSIREDSLKVPIWSISTPKPITIGIDDDIVKAIELFKTEDVGSLIVVDENYNLRGMLTEIDILRHYDLLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2P6</accession>
    <name>I0A2P6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Rpr2 multi-domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1265</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1265"/>
    <dbReference type="EnsemblBacteria" id="AFH43253">
        <property type="protein sequence ID" value="AFH43253"/>
        <property type="gene ID" value="FFONT_1265"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1265"/>
    <dbReference type="eggNOG" id="arCOG01346">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG04345">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1485841_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902555">
        <property type="term" value="C:endoribonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="4">
        <location>
            <begin position="88"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="181" mass="21059" checksum="D84CEEF629797282" modified="2012-06-13" version="1">MRLAYNEMERVFYKATFLFFEYRSVDFLRYGGRYIKSIAQKTNLPVRDDLKHFICKRCGAILIPGVNSSYRIHSKSGNSYLKVKCLNCGYSKKIIFKPRDVVKSKMVRADINIGKNGINERIIKEIDTRLKVKKVVKIRINKNFIESSGEEREEIAKKVSSLLNAELVEIRGNTFILKRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Q7</accession>
    <name>I0A2Q7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="11">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="11">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">alaS</name>
        <name evidence="13" type="ordered locus">FFONT_1276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="11"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1276"/>
    <dbReference type="EnsemblBacteria" id="AFH43264">
        <property type="protein sequence ID" value="AFH43264"/>
        <property type="gene ID" value="FFONT_1276"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1276"/>
    <dbReference type="eggNOG" id="arCOG01255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_4_0_2"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_A">
        <property type="entry name" value="Ala_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022429">
        <property type="entry name" value="Ala-tRNA_lgiase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03683">
        <property type="entry name" value="A-tRNA_syn_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 11" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="12">
        <location>
            <begin position="1"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="635"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="639"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFH43264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="843" mass="96890" checksum="45409E38AFACF10A" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2R3</accession>
    <name>I0A2R3_FERFK</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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        </lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43270">
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        <property type="gene ID" value="FFONT_1282"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG12282">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2327155_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="98" mass="11497" checksum="7B69796E85A4B298" modified="2012-06-13" version="1">MEVKIYAYEGKSSLIDKKTFDVVDDFLLRSMHIEAVYSILKLIGKVKIEDLEGILNEGELRNLKFLKECTISDREKIEKISSILKEEKKRDFLILKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2S6</accession>
    <name>I0A2S6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1295"/>
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        <property type="protein sequence ID" value="AFH43283"/>
        <property type="gene ID" value="FFONT_1295"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1295"/>
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        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_168009_0_0_2"/>
    <dbReference type="OMA" id="LYGLPMF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="121" mass="13790" checksum="7B07C6754F621136" modified="2012-06-13" version="1">MSEGISKKKMIEIELKSISDLARLCATTSPIGQTMHIIRYESNNETRLGIIAILRDFYELRGIPIFYYVKCAENDNCKKSHYISFRITENGENVAFADKNIPGTIMIPIIDIKELPGFLMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2S8</accession>
    <name>I0A2S8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, TrmB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="251" mass="29101" checksum="4C8C698A7560239A" modified="2012-06-13" version="1">MIENSNLPQFIISEVEPLLKLLKVYGMKKRDIEIYLRLLNSGGLTAKELSVMTGLPQSKVYESLSKLIEKGWVMKSSDRPSIFYPVNIAEVWNETKHEISKKMEEVETKVIPLLERASVGSPPLFRIFLLNEGKIQYYIEKVFSKASKEVLIAISHKEIINDEFFEKISSLKDKGAKIWMIITKGVYEFLKDKNIMVRENYKIADEMFGSGIISDEIILIFKNGNQLNALWSDHNYFVELGKIYFEHLWSH</sequence>
</entry>
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    <accession>I0A2T5</accession>
    <name>I0A2T5_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AFH43292">
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="TM_helix"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="67"/>
            <end position="90"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="110"/>
            <end position="134"/>
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        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="210" mass="23836" checksum="DDC3437D4633520B" modified="2012-06-13" version="1">MFGLSSFYDILFSVVIAVIIILVGYLIGRLMKYLIEASLKRTGFDNWLKKFTIGRALDKAGYSASEFFALVTSWFLYAFFILLGFEYIFINLNLGYFSSLILTIMKVYLWGLAKVIIIVIPGFILVDSFVGYIYSTSEIREEEIILSPIAEYLRILLYIVIVIFALDRSGMEVQVLESAMSPIIWGLTAVMIIVSVSIIISRMFKSNKSS</sequence>
</entry>
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    <accession>I0A2W0</accession>
    <name>I0A2W0_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Periplasmic binding protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">FFONT_1329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="58"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="376" mass="41963" checksum="D2E8E020C6D7337B" modified="2012-06-13" version="1">MNVRTVVLTAVVLILIIAFCCEYFYTHNPSSAQEKVSLQRYVIDDAGRNVTLPANVSRIVAIGPGMLRLICYLNATDMLVGIEQSELQWGPTGRDYAMAYYDEFKNLTVIGPGGPGKAPNPELLLSVKPDLIIMSEIYCQFIDPDTLQREVNATVIVLDYGPAGYLDFKELNNSLTILGIALNREDRAKSLINYIQSIVDDLNNRTNNITMRPKVYVGAVSYKGAQPFTSTQSPFPPLSLLNTKSIADNYSNKTGFVSLDFEYLISEQPDVVFIDEGNLQLVKQSFESNPSPYLQLNAFRNGEVYGILPFNYYDTNIATALADAYYMGKILYPDRFKDINPAEKANEIFNEFLGKPLYQEYSAAYGGFKCLSNAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Y1</accession>
    <name>I0A2Y1_FERFK</name>
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        <submittedName>
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    <organism evidence="2 3">
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
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        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="138" mass="16277" checksum="D1AC4E70660920D9" modified="2012-06-13" version="1">MSASQSAIYVSKEELLKKAEELYKSGYDHVISISAVDYPERNEIELVVHVSSYTRKDISPKILEIRTKLDRSSPRVNSLTKVWRSAEFQEREAHEMFGIFFEGHSDLKYLLLDPEEFRFKYPLRKDFKVIVEDIMLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Y3</accession>
    <name>I0A2Y3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane-bound oxidoreductase, subunit MbxM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1352"/>
    <dbReference type="EnsemblBacteria" id="AFH43340">
        <property type="protein sequence ID" value="AFH43340"/>
        <property type="gene ID" value="FFONT_1352"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1352"/>
    <dbReference type="eggNOG" id="arCOG01546">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_2_2"/>
    <dbReference type="OMA" id="WSGWASN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="342" mass="37608" checksum="C17207DA5956392A" modified="2012-06-13" version="1">MGIIEAILNIILYPPIFYLVIVPGLITVMGALIFLIWAERKIAGRIQMRYGPLEISPKIGGAIQLLADLMRYMFQEIIIPRNVDLLPYFIAPILGFVVALLPIASIPISPYYYPSPTSNSILVAVGLTTLPPLLTILAGWSSNNKFSLLGSTREAFLISAYELLIILSAVSAVIIYSTPDFTVAVQEQHIWGIVLNPISAITFYVSVLMATGRFPFEIAEADSEIVMGAYTEYSGLMYGLSMGIPYTRMFVYNLIFTLLFLGGWSPLIVIPGHAFISFVLIPAIIVVVKALIVSLTMVFTRAIYGRLRIDQALGGAWKFWFVVTMVGIAWSIALVWISGGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Z1</accession>
    <name>I0A2Z1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Replication factor C small subunit</fullName>
            <shortName evidence="6">RFC small subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Clamp loader small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rfcS</name>
        <name evidence="8" type="ordered locus">FFONT_1360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the activator 1 small subunits family. RfcS subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1360"/>
    <dbReference type="EnsemblBacteria" id="AFH43348">
        <property type="protein sequence ID" value="AFH43348"/>
        <property type="gene ID" value="FFONT_1360"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1360"/>
    <dbReference type="eggNOG" id="arCOG00469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042324_2_0_2"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01509">
        <property type="entry name" value="RfcS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023748">
        <property type="entry name" value="Rep_factor-C_ssu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="42"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="50"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH43348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="326" mass="37175" checksum="9FA655C80818B230" modified="2012-06-13" version="1">MSDENSENYLLWAEKYRPRSLDEIVDQEETIIRLKKFVKEKNAPHMLFAGPPGTGKTTAALAFAHDLYGKNYQQFVLELNASDERGIDVIRGKIKEFARTSVVGGVPFKLIILDESDNLTSDAQQALRRMMENFTLTSRFILIANYPSKIIEPIQSRTALFRFSPLKKEDVIKRLKWILENESVSYEESALEAVFEISEGDMRKAINVLQSASAIGKVTVDTVYKVVGLAHPKEIREMLNLALSGDFNGARERLRKLMMDYGLSGVDVIKQIHKEIFSNEIDLSEEMKLMIADYTGEILFRITEGSDDEIQLNSFLAWLVLLRKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Z3</accession>
    <name>I0A2Z3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1362"/>
    <dbReference type="EnsemblBacteria" id="AFH43350">
        <property type="protein sequence ID" value="AFH43350"/>
        <property type="gene ID" value="FFONT_1362"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1362"/>
    <dbReference type="eggNOG" id="arCOG08854">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1451365_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="186" mass="21009" checksum="7037AC311E6196A2" modified="2012-06-13" version="1">MPQKNNEKKNESPVKAVAYINVYTPESIEVRGIKLKAYVLNDKESAIKEITAPSVLDIVSKAREILKKHLSGELKNLSGGLITVDISGKGFSFYYGEYIGEERNKELLFPRPAKLLKIGYYVNENGEMKRKLAKKSFDKEYYVYEGEIQFPQGIEGIVLATEYGSRSIFRSGTGNEVARSNKEQQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A300</accession>
    <name>I0A300_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent DNA helicase Hel308</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hel308</name>
        <name evidence="4" type="ordered locus">FFONT_1369</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. Hel308 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1369"/>
    <dbReference type="EnsemblBacteria" id="AFH43357">
        <property type="protein sequence ID" value="AFH43357"/>
        <property type="gene ID" value="FFONT_1369"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1369"/>
    <dbReference type="eggNOG" id="arCOG00553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006553_3_0_2"/>
    <dbReference type="OMA" id="MFLNANI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00442">
        <property type="entry name" value="Helicase_Hel308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022965">
        <property type="entry name" value="Helicase_Hel308"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="1" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="2">
        <location>
            <begin position="33"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="3">
        <location>
            <begin position="233"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="708" mass="80033" checksum="4E2062D6CC6B3C2B" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I0A312</accession>
    <name>I0A312_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1381"/>
    <dbReference type="EnsemblBacteria" id="AFH43369">
        <property type="protein sequence ID" value="AFH43369"/>
        <property type="gene ID" value="FFONT_1381"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1381"/>
    <dbReference type="eggNOG" id="arCOG05990">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_948655_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="293" mass="32604" checksum="39A696F2B0F8CDA7" modified="2012-06-13" version="1">MKLTKRIANEYGGVVLEDSPIPPLLTREDDVLIKAERILLTPIDHMCMKGYLLAKARGTLGTFAYGRALESKELSGSPEFSTYPNSCDCFPIISREGVGYFHTTFPSKCAKVPPRGLEAKEFFFIYDLILEIERTSEGRVLVVGGEGLQTLLLSHVLEGAVFTGIDDRKFLKEGRRTVSLENIEGSRWDTVVINTLSVGKASLVLRRIEASKVVVNPFSLCLFKEISIPSSGEVEIVASFPRRSYYGGERYEELEEARRMSGLHTTAHAGELNYPLTSPPNQYFTLIAGNEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A324</accession>
    <name>I0A324_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1393"/>
    <dbReference type="EnsemblBacteria" id="AFH43381">
        <property type="protein sequence ID" value="AFH43381"/>
        <property type="gene ID" value="FFONT_1393"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1393"/>
    <dbReference type="eggNOG" id="arCOG01446">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1222483_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010163">
        <property type="entry name" value="Csa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01884">
        <property type="entry name" value="cas_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="226" mass="24669" checksum="A333A38C1C139850" modified="2012-06-13" version="1">MERCFIINIGFHADVGLRRITDSSIKPGEKIILISGPENPSSGKALSEFKLFATKAGIKESDIKVLHLDLDKPWESAVKLADLISKECSEGELVLELGGGMRGTAVLILLSAIASGKRVSIETTIEGSPQSLRIPWGFLRFVISGIGSRDGDILEALYNNRGSTPKDISRILNIGEKTIVNRITKLKKMGFIEKRGRGLPSLTPWGEAAAMLNSILKDRKEKQIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ54</accession>
    <name>H9ZZ54_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilT protein domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
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        <source>
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</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    <dbReference type="EnsemblBacteria" id="AFH42046">
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    </dbReference>
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            <dbReference type="EMBL" id="AFH42046.1"/>
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    </evidence>
    <sequence length="42" mass="4872" checksum="7E29975D3F60B18D" modified="2012-06-13" version="1">MLNYYILLIIISQKFLGIDGPFAIFSSESEKLLLIIPHKFMN</sequence>
</entry>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="AFH42064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="62" mass="6815" checksum="7D510C36BFB1906B" modified="2012-06-13" version="1">MSVKDIAKATGCGEKTVVNRISYLKKLGLVERKGRSPLKLTPWGEAAALLSEESRELLEKKS</sequence>
</entry>
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    <accession>H9ZZB1</accession>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    <feature type="domain" description="Cas_APE2256" evidence="1">
        <location>
            <begin position="51"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42068.1"/>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="247" mass="27525" checksum="03E30CCE41B252D1" modified="2012-06-13" version="1">MSEKKYHVIVTVGTSILRNTSSEDTERACSDPKSQKCLEFLVKKLNFDPSKVSAEVNSMRTYLNEKERKIASVTLLASDTDEGKVCAEALRSFFEDREIKAEVMVVEKLGKAFEVGTSNLMDAIAKAVATARKEGLEIILNLTGGYKAESAIAYVSALLLSVDKVLYIHETLRVPVELPALPLSIKGEELDRLSRLTELNPYCKDWLEAGFNVREIEDLVDKGLVEMDGGKCKVRDIVKEILKIYES</sequence>
</entry>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    <dbReference type="OMA" id="IWRWWAR"/>
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="417" mass="47488" checksum="4157E7FCAECAE14E" modified="2012-06-13" version="1">MIEEILRLKVTNFTPLLVGWYEPNIVDPIGLRPTELKGIWRWWARAFACGVLYDRGCNPLPSDLVKIVGKDLGLGYAGVNIGGKSAMPSKYIIRVNETFEPTNFKKASINKTDLKELQRIVLLLGGRPESLEPNNAEKVILKRRGKGGVERTLELYLPQSRFYTISLFSTESDSNKKAAAVLSFLSAIMLMGIGKGGRRGLGSLDIIEIEKQPEINGKRINELSLKVEDLVDKTYEHFRNLDSIKDPQCTKKSIDKNLPNFPCLSKNHEDITSIYHVEARDESKKAFDVFKDLHNLFNLSMRSRERNFPKICSNLKEYDWFLGIPRKGKYKEEKEGGKSEEWRRPSPVILSAHDNKIFGNGAFLTVLASADWPDIMINGKQIDSQQIGDAKKTFENCLKAYCSTKYKITRIWPRRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZC0</accession>
    <name>H9ZZC0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    <reference evidence="3" key="1">
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="56"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="105"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <end position="238"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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    </evidence>
    <sequence length="269" mass="31701" checksum="E15983D7B441CA6A" modified="2012-06-13" version="1">MSSDRERIEALLKKAEEISGESKRTDYKMPIILPFIPAILAVIAMILMLFGFFYYFPNPGHIYYAVSIYQDIPPNGMVIYPFREIGYGILLIAVLMYFYVVYKWIKRRNDHFARTLSFYENIAEAADILKFKRAYSIKSRFNELKEVDSNTKSAIANAILIIVPFYIFYVFHFLNKDFYKHSEKEKLLLSELFDEIKEKIPSFTRKAEEFAIVPDRSTFLYIILYLISSGLFGIYWVYTLTNDPNKHFESHELIEKELITALREISSKQ</sequence>
</entry>
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    </protein>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Gumerov V.M."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            <dbReference type="PubMed" id="24366681"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0092"/>
    <dbReference type="EnsemblBacteria" id="AFH42085">
        <property type="protein sequence ID" value="AFH42085"/>
        <property type="gene ID" value="FFONT_0092"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_3162949_0_0_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="47" mass="5559" checksum="C7B956878BF98EBE" modified="2012-06-13" version="1">MPNRATSQYSHELGKYYANTLINLQPSSFLHDVQRFSPEKLFTMHFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZF0</accession>
    <name>H9ZZF0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA primase large subunit PriL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">priL</name>
        <name evidence="8" type="ordered locus">FFONT_0115</name>
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    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
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        <cofactor evidence="7">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="7">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
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        <text evidence="7">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH42107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFH42107"/>
        <property type="gene ID" value="FFONT_0115"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0115"/>
    <dbReference type="eggNOG" id="arCOG03013">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OMA" id="KYMPYSC"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PriL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00701">
        <property type="entry name" value="DNA_primase_lrg_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
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        <property type="entry name" value="DNA_primase_lsu_PriL"/>
    </dbReference>
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        <property type="entry name" value="PTHR10537"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
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    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0639">Primosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="344"/>
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        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="387" mass="44396" checksum="8588A3588518A5C8" modified="2012-06-13" version="1">MNDMPSGRSIFRLLRYSFLLDDPIGYLRSYEGIPQGMSLIDIIEMHGAIPRIREIISSVIEKESYSFERDEKNLKREAVSLYSAMIVTSSVKDNWLMNRFSISIAKSFGEELNGFDEETMIKIARDYLKIGVRFLAEPLVIPIRKLSRGDQRKSFTFSITIFDYMRLGKRLEGDEKWRFSNQLISGGMVYIQRAELQRLMEEAVYYKVLDKLKRISNDISDISILPPQLKDIAVEVQSQVAKRRISFYGESQIGGEGGGAIAYKPELFPPCIKNILRKASNGENLSHQERFQIATFLLNLNISIDDVLEVFKQLPDYNEKIARYQVEHLAGKRGSGIKYKPYDCEKSKAIGLCVEDCGTKTPIQKYKIELRKHLKKGGDNNDKSRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZF2</accession>
    <name>H9ZZF2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Uridine phosphorylase</fullName>
            <ecNumber evidence="5 9">2.4.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FFONT_0117</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PNP/UDP phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.3" evidence="5 9"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0117"/>
    <dbReference type="EnsemblBacteria" id="AFH42109">
        <property type="protein sequence ID" value="AFH42109"/>
        <property type="gene ID" value="FFONT_0117"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0117"/>
    <dbReference type="eggNOG" id="arCOG01324">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068457_0_0_2"/>
    <dbReference type="OMA" id="MSDVFHL"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00633"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009164">
        <property type="term" value="P:nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018016">
        <property type="entry name" value="Nucleoside_phosphorylase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010058">
        <property type="entry name" value="Uridine_phosphorylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01718">
        <property type="entry name" value="Uridine-psphlse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01232">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="10">
        <location>
            <begin position="33"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="287" mass="31354" checksum="A826E0BDDCAD3021" modified="2012-06-13" version="1">MNSLEGGKIKADSPTTDGRKLYHLGISQGDVARYVLLPGDPERSELIAKTWDEWRFVARHREYVTYSGKYKGAEISVTSTGIGGPSAAIAVEELLRAGADTFIRVGTTGAIKGEIEIGDLIISSGAVRLDGTSKQYAIPEYPAVSSYEVLLALVEAAESLNKRYWVGITASTDSFYLGQGRPGYKNFMNSWAKSIISELKSLNVLNFEMEASTIFTMANIYGARASSICAVIANRVTNEFVPNAGVDDAVKVADEAVKILSEWDELKRNSGKRSFYPSLLLKDKMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZF3</accession>
    <name>H9ZZF3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0118"/>
    <dbReference type="EnsemblBacteria" id="AFH42110">
        <property type="protein sequence ID" value="AFH42110"/>
        <property type="gene ID" value="FFONT_0118"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0118"/>
    <dbReference type="HOGENOM" id="CLU_2177786_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="109" mass="12806" checksum="D837EFB988390049" modified="2012-06-13" version="1">MSEKKVKLLLNIELSDKGFLKIVNAGSDKIIVWKIELVYYITVTPLDQISQEQRYLKKQITETIDKNKELEPGGALLYYTKLPKDAIEEVNVYYQIGNMFKKETYKTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZF6</accession>
    <name>H9ZZF6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42113">
        <property type="protein sequence ID" value="AFH42113"/>
        <property type="gene ID" value="FFONT_0121"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0121"/>
    <dbReference type="eggNOG" id="arCOG06043">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161775_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="116" mass="13692" checksum="96FAC403C529F1E4" modified="2012-06-13" version="1">MCYSPLLPEPRADIVKKGICDGDELSYSRCKYYTKVLKDEGKNEEYLIQKYRPDPMLNMVSYEPKSGCEFFKVVKSKNGYVVFCDALQRYLTKHEIELCMKDFERCPIRRVLSLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZF9</accession>
    <name>H9ZZF9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NAD kinase</fullName>
            <ecNumber evidence="5">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nadK</name>
        <name evidence="6" type="ordered locus">FFONT_0124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
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        </reaction>
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        <cofactor evidence="5">
            <name>a divalent metal cation</name>
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        <text evidence="5">Belongs to the NAD kinase family.</text>
    </comment>
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        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
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        <property type="entry name" value="NADK"/>
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        <property type="entry name" value="SSF111331"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
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    <keyword evidence="3 5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
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            <end position="147"/>
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        </ligand>
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    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
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        <ligand>
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        </ligand>
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        <location>
            <begin position="186"/>
            <end position="191"/>
        </location>
        <ligand>
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        </ligand>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
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    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="280" mass="31784" checksum="0EA78C6B45501605" modified="2012-06-13" version="1">MESSGDLGMKKDECNWTALYVNYSSKIALEIADQILNEAREIGEEVKIIYRKTGLLEYDGYKVESKKPCRLIIVGGDGTLLNALQDETNHDAIIATVAGGRRNFYYDASSIQGRSILKRLLNGAYVEQKVWGLKLEMGRRKHFFFNDAVIASNHMKVIELNVFINGRKLYEVAGDGIIISTSSGSSAYNISCGGPLVDFSHPSILLSPLNSTILWNRPVVLDYLSSVDIEIERNIEYSKVILDGTKVLDPEEKIKIYMYEKPIRFARFERLQTYEKIFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZH9</accession>
    <name>H9ZZH9_FERFK</name>
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        <submittedName>
            <fullName evidence="9">Putative ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FFONT_0144</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
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            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccaceae</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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            <end position="301"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="351"/>
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        </location>
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            <end position="404"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="411" mass="43603" checksum="2D93C48469752CD2" modified="2012-06-13" version="1">MSIKRFFSLLGMSYKMAVKSLGSRKLRSILTILGIIIGPAVIVMMGAVVGGYSQYILNQVTSLGQNNIMITPSSDYTLTSSDLSYFKSFSYVVNAVPYYLTQATVTVGNSQEQIYIYCTDVNFVLHAIGGLEIEEGSAPSQGDVLDALIGHKVAYDQNGNLEYGVGDVVPLKVFTKITNGIPQYKTVNVIVSGVLKEYGGALIFSPDQTIFLDTDAGQKLLGLNSWSGILVQVSDPIYVKDFVSTVESTYGNKVSVISFSAIADIVSSITGAVNYINYVASLSAFAVAIAGTTATMVTSVIERTKEIGVMKSIGYTNREIIIMILSESTLMSFIAAVAGSLLGVAGSFVLGGSGMTIRAGTNTVVINSHPLFSAHLFITSIGLTILVGVVGGILPAYMASRIPPAVALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZI9</accession>
    <name>H9ZZI9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC-type carbohydrate transport system, ATPase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0154</name>
    </gene>
    <organism evidence="7 8">
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42146">
        <property type="protein sequence ID" value="AFH42146"/>
        <property type="gene ID" value="FFONT_0154"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0154"/>
    <dbReference type="eggNOG" id="arCOG00177">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="OMA" id="MNGNPKA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="329" mass="37146" checksum="870931B8C61B3A8D" modified="2012-06-13" version="1">MTLRLENLRKRYGQFELRIEEYTFKEKSYNVVLGSSGSGKTTTLRLIAGLELPDEGKIILDGVDITNVPAWKRDIGLVFQNYALYPHLTAYENISVPLKIKKLDRKTIDEKVKNVAEILGISSELHKYPHQLSGGQQQRVAIARALVKEPKILLLDEPLSNLDARLRLEVRVFLKELQRKLNMTVIHVTHDQEEAMAIADNIVILNSGKIVQDGSPAEIYRKPKNTFIFTFIGLSNLLPASFFGIDDADLVGFRPEDAEIVNTDGDISGLVEEIQYLGAYKLLEISIDEKHSVIVRVLPSEEISEGQKVGISIPRDLMLKFKNEERVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZJ2</accession>
    <name>H9ZZJ2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methylated-DNA--protein-cysteinemethyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0157"/>
    <dbReference type="EnsemblBacteria" id="AFH42149">
        <property type="protein sequence ID" value="AFH42149"/>
        <property type="gene ID" value="FFONT_0157"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0157"/>
    <dbReference type="eggNOG" id="arCOG02724">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_5_2"/>
    <dbReference type="OMA" id="DICEAVY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_binding_1" evidence="7">
        <location>
            <begin position="10"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="102" mass="11470" checksum="4D8689EA8DE4568F" modified="2012-06-13" version="1">MDKLELVKILLQLIPPGKVTSYSELSKITGWSPRSVGKILSKNDEPILVPCHRVVMKNGNLGGYSAFSGKEFKRRLLELEGVEFCSNGKIKRSNFYKLSEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZK7</accession>
    <name>H9ZZK7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42164">
        <property type="protein sequence ID" value="AFH42164"/>
        <property type="gene ID" value="FFONT_0172"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0172"/>
    <dbReference type="HOGENOM" id="CLU_3002985_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="56" mass="6436" checksum="CAD4EC50E4D6100E" modified="2012-06-13" version="1">MFSWRPSSEIFVRENFFYIGTSGGSLMNINAFSISLRKASYFFNIIAFNLLSNNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZN3</accession>
    <name>H9ZZN3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase, family S9c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0199"/>
    <dbReference type="MEROPS" id="S09.071"/>
    <dbReference type="EnsemblBacteria" id="AFH42190">
        <property type="protein sequence ID" value="AFH42190"/>
        <property type="gene ID" value="FFONT_0199"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0199"/>
    <dbReference type="eggNOG" id="arCOG01646">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG03383">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008615_2_1_2"/>
    <dbReference type="OMA" id="YIHGGPK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S9" evidence="3">
        <location>
            <begin position="432"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="647" mass="74440" checksum="2254B68BC388BF2F" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZQ0</accession>
    <name>H9ZZQ0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0216"/>
    <dbReference type="EnsemblBacteria" id="AFH42207">
        <property type="protein sequence ID" value="AFH42207"/>
        <property type="gene ID" value="FFONT_0216"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0216"/>
    <dbReference type="eggNOG" id="arCOG08849">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1159099_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="238" mass="27589" checksum="7589728158A4D235" modified="2012-06-13" version="1">MLREIISFLANTIINSIFINPSVPHRRAHIFSKLLFVISIAVPFYERPILGFFFIAEIFLIYLLSAKSFLEPTSMIIISSIPAFWMAISGMIVFALSGTISISWFAEILYKTLFYSLIAMLTVSLITPSDISSILRFFTKKIAYPYLLWSLIPYQLKDAVISLKVQELKKSPVSSSVFVVFSEQLERSDQITIANIHRLESNIKRFIYKRRSKKFTLFFFILFVINFALMLIFQYINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZS6</accession>
    <name>H9ZZS6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <shortName evidence="8">GAPDH</shortName>
            <ecNumber evidence="8 11">1.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">gap</name>
        <name evidence="13" type="ordered locus">FFONT_0242</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8 11">
            <text>D-glyceraldehyde 3-phosphate + NAD(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 11">
            <text>D-glyceraldehyde 3-phosphate + NADP(+) + phosphate = (2R)-3-phospho-glyceroyl phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10296"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.59"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8 11">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 11">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.59" evidence="8 11"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0242"/>
    <dbReference type="EnsemblBacteria" id="AFH42233">
        <property type="protein sequence ID" value="AFH42233"/>
        <property type="gene ID" value="FFONT_0242"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0242"/>
    <dbReference type="eggNOG" id="arCOG00493">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069533_0_0_2"/>
    <dbReference type="OMA" id="NAIVPNP"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047100">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00559">
        <property type="entry name" value="G3P_dehdrog_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006436">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_2_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01546">
        <property type="entry name" value="GAPDH-II_archae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 10 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 8 11" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="12">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="8">
        <location>
            <begin position="145"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="8">
        <location>
            <begin position="200"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8 9">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFH42233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="347" mass="38456" checksum="0E6629D6947135DA" modified="2012-06-13" version="1">MKSYARVLVMGYGVIGKRVADAVVLQDDMKLVGVGDVSSDWRIKLAQKKGINVYAVGNDAKEKMEKSGIKVEDTVESLLKSGAVDIVVDATPKDIGARNKETLYKKYGVNAIFQGGEKAEIVDVSFIAQRNYREALGKKFIRVVSCNTTAIGRVIGGLHEKIGIKKARVSIIRRAVDVWESHSTGIMNTVVPESSIPSHHGPDVKTVVKNLNIVTMAFKGSHNLFHMHSGFIEFNRPISKDEVLNVLNAEPRVSLIAYKDGLMGLNSVFELSRDLNRPRGDLYEVPVWSDLMKVEDNELYLIWATGNESIVVPESIDAIRASLEIEEEPEKSIQKTDKTLNITKSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZV8</accession>
    <name>H9ZZV8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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    </dbReference>
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            <end position="66"/>
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            <begin position="1"/>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42329.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="414" mass="46887" checksum="FA32DDB3BD90590D" modified="2012-06-13" version="1">MLLNLFRVKFLKILELSRKAYILKLKNALNIRWVEIFKDLSKKIRMDPFYVVMFIEGLAFGTYIVTIRTNIGMENYNAYSFLTLIAAMETIPGIFSVFAGGISDKIGRKKIIFFSGLMSSIFLILLSKVQLSQLPIFVFLFMSFYTMFYPIIFGISISKSKGSGYSLSKFLFFNSFGWSLGGILPGLILNLWNLNILYIIAAILIIIASVITVISYNEKEYQDPTVTLTDFKNEIKKAIPFLFPLILGSAGFYMLNSIMSLRLFISVNNILLYGIFYNTITGLLSSIARLIAGKAIEKIHPYKVTFSSFFSYLILALLMEKANSTLTILLWLLPIYPFFETSSYYVLGRMIKTTFHSTASGLFTTAVSLGGIINLSLSLVFYHSSYQTLLIIDSILLLIPSIYLIFLVKSSNRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I0A026</accession>
    <name>I0A026_FERFK</name>
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        <recommendedName>
            <fullName evidence="4">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FFONT_0343</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
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            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
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        </reaction>
    </comment>
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    <comment type="similarity">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
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            <end position="329"/>
        </location>
    </feature>
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            <end position="394"/>
        </location>
    </feature>
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        <location>
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            <end position="539"/>
        </location>
    </feature>
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            <end position="915"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="789"/>
        </location>
        <ligand>
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        </ligand>
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        <ligand>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="923" mass="103446" checksum="B8FFAABB97D35EEA" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A033</accession>
    <name>I0A033_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42340">
        <property type="protein sequence ID" value="AFH42340"/>
        <property type="gene ID" value="FFONT_0350"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0350"/>
    <dbReference type="eggNOG" id="arCOG07442">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200516_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="58" mass="6649" checksum="850E892B5F9FD9D5" modified="2012-06-13" version="1">MEYEAFDVKAKKKVKLTNVEVVTLKNGRLAIKGKSPETGITVYRLLSKKEIEKLQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A037</accession>
    <name>I0A037_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ZPR1-related zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0354</name>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="478" mass="52950" checksum="C8BDB14AFA52BBB5" modified="2012-06-13" version="1">MLKSKKTIAKDLSSIVSDGNVITDESTIKVYAKNASHMEGNAIAVVFPNNTEEVSEIVKYCYKNNIKIYPQASASELTGSSLPREDGVIVSFERMNKIKNINILDSYVVVEPGVRLYDLNLELSIYGFMFPIDPASIKIATVGGAINTGAGGMRGVKYGTMKDWVNELEIVIPNEYGTILKIGCKTSKCRQGYDLVRLIVGSEGTLALVTEATLKITPLPENVITLAAFFDDIEGLVNALLEIKKNKLDILIMEFVDDKSVELTLKVLKINIAGNGHYFVTSIITSPESSERVLSLVENILKRNGAKNVYKAKTLDEAESEGIFDIRRNYDIGLRDLVVKMRKNPASKIIDYNEDISVPPSKLPEAVRRIREIEKRYGLPLTLAGHVGDGNLHPVIKIEEKNIEQIETYEKMKSEILKAVIELGGTVSSEHGIGLDKKKDLIMELKSKNSVKAIDIMKSIKQTFDPKNILNPGKIFEV</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AFH42419">
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        <property type="gene ID" value="FFONT_0429"/>
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            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="61"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51740"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42419.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    <sequence length="141" mass="15970" checksum="2CB879E23F8894A4" modified="2012-06-13" version="1">MVSLKLSSVVKIDPKGRVTIPLFIRESMDISEGRYMVLIADVDKKEMILTPITTKNEELYEIRVELQDKPGALADLTKAFLDMKLDILISKCSTIKRGEIGECTMIVEPGNKEIKPEEIEKKISELPVIYMVSVKPVEKNF</sequence>
</entry>
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    <name>I0A0C3_FERFK</name>
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    </gene>
    <organism evidence="3 4">
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        <lineage>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="407" mass="45464" checksum="618F9B6C8E21520F" modified="2012-06-13" version="1">MVNYLPPLIGVIGKTNVGKSTFFSAATMTTVEISNRPFTTIKPNHGIGYVKITCPHLDFGLEACNPRTGYCQNGNRFVPIELLDVAGLIPGAHMGRGLGNKFMDDLRKADAFILVIDASGSTNEEGNPVPPGTYDPIEEVKQIINEVDLWLAKIVSSDWQKFSVSVETSRKNFVDALYDKISGLSIKRSHVIEVLERIDLTNKRPSNWKEEDFYIFAKELRKTAKPHIIAANKADLPTAYENIERLKKEFPEVPVVPVSSESELALRKAAKMNLIDYIPGDSIFFIKENVKLTPQQEVALKYIEEKVLKRYGSTGVQKVINSIIYDVLKKVVVFPVEDINKLTDKNGNILPDALIVDHEASPKVVAGLIHTELEKGFQYAIDARTKQKMGEGSRVYDRLVFKIVSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0E6</accession>
    <name>I0A0E6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L18e</fullName>
        </recommendedName>
    </protein>
    <gene>
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        <name evidence="5" type="ordered locus">FFONT_0463</name>
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    </organism>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0463"/>
    <dbReference type="EnsemblBacteria" id="AFH42453">
        <property type="protein sequence ID" value="AFH42453"/>
        <property type="gene ID" value="FFONT_0463"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0463"/>
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        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OMA" id="WRLERPR"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:ribosome"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_L18e/L15P" evidence="4">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="125" mass="14115" checksum="3174322A43D13001" modified="2012-06-13" version="1">MARTGPTNLLKRKLIKGLKKLSKDEQANIWERISEELSAPRRKMVEANISKINRNANEGEVVVVPGKVLGSGKLTKKIVIIAESYSMKAYEKLKKSGAEIYLLDDLLRNKELKDKIDSLPKRIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0I4</accession>
    <name>I0A0I4_FERFK</name>
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        <recommendedName>
            <fullName evidence="5">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rpl18</name>
        <name evidence="6" type="ordered locus">FFONT_0501</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42491">
        <property type="protein sequence ID" value="AFH42491"/>
        <property type="gene ID" value="FFONT_0501"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0501"/>
    <dbReference type="eggNOG" id="arCOG04088">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056222_2_0_2"/>
    <dbReference type="OMA" id="MAHGPRY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:5S rRNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rbsml_L5_euk/L18_arc"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
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    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="199" mass="22516" checksum="848C9F769EA054BD" modified="2012-06-13" version="1">MVVGGPRYKVARRRRREGKTNYRKRYTYVFSGRIRLVVRKTNKYIEAKIVDCDPKGDLVKVSAHSIELIKKYGWKGSGKSTPAAYLLGYLIGKRAIEKGLKDAVLDIGLYRVVKQSKLFAVVKGAIDAGLKVPVSEEMLPSEGRIRGEHIANYAKMLKESNPERYNRQFSKIINSGLLPEEYVAHFESVLNAIKNEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0I5</accession>
    <name>I0A0I5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl19e</name>
        <name evidence="7" type="ordered locus">FFONT_0502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0502"/>
    <dbReference type="EnsemblBacteria" id="AFH42492">
        <property type="protein sequence ID" value="AFH42492"/>
        <property type="gene ID" value="FFONT_0502"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0502"/>
    <dbReference type="eggNOG" id="arCOG04089">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083919_1_1_2"/>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01475">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_L19/L19e_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_L19/L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_L19/L19e_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015973">
        <property type="entry name" value="Ribosomal_L19e_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015974">
        <property type="entry name" value="Ribosomal_L19e_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="RPL19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="PTHR10722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="SSF48140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L19e" evidence="6">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="153" mass="18097" checksum="88CF4E2B9455D8C6" modified="2012-06-13" version="1">MSDYTLQKRLASKILGIGESRVRIYIKSDDDREDLENAITAEDIKKLIKRGVITEEPEKSNSRGRWRELKEKRSKGQRRGPGKRKGVASARIDPKRRWISSIRKMRRYLKYLRDKKIITTQQYRRYYKLAKGGAFSSLSVLRMHIEKEIGQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0N2</accession>
    <name>I0A0N2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase, family S54</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0549</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0549"/>
    <dbReference type="EnsemblBacteria" id="AFH42539">
        <property type="protein sequence ID" value="AFH42539"/>
        <property type="gene ID" value="FFONT_0549"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0549"/>
    <dbReference type="eggNOG" id="arCOG01768">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_611948_0_0_2"/>
    <dbReference type="OMA" id="IWFAEQV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="89"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="472" mass="53734" checksum="0533B2864CFD0A01" modified="2012-06-13" version="1">MNFFEKIFIITVFNKYIRNLKEVLSLVVIPREEQPALKKAWFTYSLILINIIVYVYTSYNNLLLTSTNESIYKLGFIPQILLEDPVQGVLRIFTSMFTHANIFHIFFNMYFLWIFGRSVENAIGHKRFLILYLLSGIAASIFYFAFIPIGGYDSLVIPAIGASGAISGILGAYLLLFPNTKLMFCLFFIFIPICIPVSSIIFLIIWFSEQVIYGFLELGGVAYFAHVGGFITGIFLSYVFFKDSSVRLNYHLLMEYSSMMEKIGIKGMPRRIGKWTKYFLTFLFILILLAFSSGTAEVYATNTNIYFLNVTANGQSDVVVLKLYSGKAEVSQSSVDEVRILLNRIPESFICNKELANKNITYREFYNVTINGVSVPVFLDAVFSYRYDGIVDYASGNISTYIVLTDIYGNSNLDGKVNISFNMTSQYTNIKEPLVISSSASILLTIGAIISLFRIEEALSVSFYDLWRERWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0N7</accession>
    <name>I0A0N7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Adenylosuccinate synthetase</fullName>
            <shortName evidence="7">AMPSase</shortName>
            <shortName evidence="7">AdSS</shortName>
            <ecNumber evidence="7 8">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">purA</name>
        <name evidence="9" type="ordered locus">FFONT_0554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 8">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="7 8"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0554"/>
    <dbReference type="EnsemblBacteria" id="AFH42544">
        <property type="protein sequence ID" value="AFH42544"/>
        <property type="gene ID" value="FFONT_0554"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0554"/>
    <dbReference type="eggNOG" id="arCOG04387">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_2"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 7 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="246"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="11"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="278"/>
            <end position="280"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="335" mass="36860" checksum="BC2C922E88E6BBAD" modified="2012-06-13" version="1">MLTVIVGGFFGDEGKGKIAAYLAIADNCRYAVRTGSINAGHTVYFEGKAYKLRSIPSGFVNKSTELLIAPGALIRLDVLWNELKELNVKERTKIDYNAGIIEEKHIELEKRDSVLTSIGSTFQGVGAAMSDRVLRKLKLAKDTEELRGMLIDVSEKVNYAVDSGENVIIEGTQGTFLSLYHGTYPYVTSRDTTASGIISEVGIGPKKVGDVILVFKSFVTRVGEGPLENEMSKEEAEKLGLVEKGTVTGRMRRVAPFNVNLAKRAIMLNSATQIAITKIDWLFKEAYGVKEWSKLPPEARKWIEGLEAELKVPITLVGTGEDTMQVVDRRKEVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0N9</accession>
    <name>I0A0N9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="6">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purC</name>
        <name evidence="8" type="ordered locus">FFONT_0556</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0556"/>
    <dbReference type="EnsemblBacteria" id="AFH42546">
        <property type="protein sequence ID" value="AFH42546"/>
        <property type="gene ID" value="FFONT_0556"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0556"/>
    <dbReference type="eggNOG" id="arCOG04421">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061495_0_0_2"/>
    <dbReference type="OMA" id="EFCYKND"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR_synt" evidence="7">
        <location>
            <begin position="8"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="245" mass="28008" checksum="5BD0F3B72DEF0AF6" modified="2012-06-13" version="1">MEPSFFPIYVGKSKNIYKHPYDEKLLIMEFKDDVTAGDGAIRTIAPHKGIINARTSHFFFKLLEGKGLKTHMVEFNGNNKMIVKRLKMIPIEFIARNYAYGSLLKRLPLFKLMQPLDPPLIEFHYKDDSLHDPLITHDDIILSGLLTKGQLGKIVSITADINMILRTFLEEKGLKLVDIKLEYGFDENGEIILADEITGDGFRVVDERGNHLDKEIFRKTKDVKLLIESYMKLASILGIDLSDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0R8</accession>
    <name>I0A0R8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, GT2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0585"/>
    <dbReference type="EnsemblBacteria" id="AFH42575">
        <property type="protein sequence ID" value="AFH42575"/>
        <property type="gene ID" value="FFONT_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0585"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014170_0_0_2"/>
    <dbReference type="OMA" id="HLVKSFY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="249" mass="27881" checksum="94E74BFB4072E432" modified="2012-06-13" version="1">MKEVSVIFPAKDEEKFIAHSVKTAKKAKNVREIILVDGGSVDNTPAIAKKLGAKVIFQSILKYPGKGVAMRDGYYYSTKDIIVFLDADIKNLTPDFINKLIEPILKGETDFVKGTFGRKSGRVTELVAKPLLRIFYPELSYLSQPLSGEIAGTSEAFSKVNWELGWGVDIGIVLDIYKAGFKIKEENLGFKDHDMKPLPMLTEMAYEVAQTIIRRATQDGKISESKGEELLAKYIEESKTQKYEEGEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0R9</accession>
    <name>I0A0R9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42576">
        <property type="protein sequence ID" value="AFH42576"/>
        <property type="gene ID" value="FFONT_0586"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0586"/>
    <dbReference type="HOGENOM" id="CLU_2230268_0_0_2"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023324">
        <property type="entry name" value="BH2638-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158504">
        <property type="entry name" value="SSF158504"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="105" mass="12148" checksum="51515D058DB9450E" modified="2012-06-13" version="1">MSEEEEVEEVEIEEEEEKEEASEMEEEESSIGFDISPDEINTMIEIVEKIEQASEGKISKEDLDKAYGELISHKAKEKEKKEKSERKKEKSNKSKKGRKPKAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0S9</accession>
    <name>I0A0S9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="162" mass="19513" checksum="129563130A9E9DD1" modified="2012-06-13" version="1">MSFKNFEEFNSLRVIGTEEYVLDVNLLKNASSDIYWRMTFKKYLKASKKKALIRYLDSLKEDDLRFSISEFLRVFLRFSLNTLFLFFLLLLPISYFASIKLFYLLLSADIINLFAFLLYKKMKGYPFLKGIVNRIKFMIFSFLVFIWTPYALREIRKFSKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A117</accession>
    <name>I0A117_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Iron-molybdenum cofactor-binding protein</fullName>
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        <name evidence="2" type="ordered locus">FFONT_0686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0686"/>
    <dbReference type="EnsemblBacteria" id="AFH42674">
        <property type="protein sequence ID" value="AFH42674"/>
        <property type="gene ID" value="FFONT_0686"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0686"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="FARAPEI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
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    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="1">
        <location>
            <begin position="21"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="120" mass="12535" checksum="8567AE84842019D5" modified="2012-06-13" version="1">MYFGDSMRKIAVVCEGSGGLEDIVASKFARAPKIVFVELEDEGRILDVKAIDNPGANAESGAAVKIIQTVIDEGAEAVVAPAFGPNAQAILDEVKVKGITVPAGTKVREAVEIAKRELGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A118</accession>
    <name>I0A118_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobyrinic acid a,c-diamide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0687"/>
    <dbReference type="EnsemblBacteria" id="AFH42675">
        <property type="protein sequence ID" value="AFH42675"/>
        <property type="gene ID" value="FFONT_0687"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0687"/>
    <dbReference type="eggNOG" id="arCOG04073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067767_1_0_2"/>
    <dbReference type="OMA" id="GIGCVVI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="323" mass="35840" checksum="159AC89A2522365B" modified="2012-06-13" version="1">MLEIAVASGKGGVGKSTLSSTLILYLKERGYDIIAVDADADAPNLHLIFEVERWDKEEPYSDSWVSEIDYFRCVNCGICHNVCTYGAVSLVEGRYYINPMICEGCLTCSLACPEKAIRRKRVNRGVIRLSYTKYGFPLWASELSPGRPNSGRLVTEIKNRAKAMAKENTISVVDSAAGIGCQVISSLSGANVALLVAEPTPASLSDLKRIHTIAKQFSLPSALVINKYDMNSEFVEEIIKYAREENIDVIGMVPYDDHVPKAMAEMRPLIKQYNEAPASKALVEIARIVEERIIRGWSDWSRSHRPSKPARYVPIIIKPGEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A168</accession>
    <name>I0A168_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0737"/>
    <dbReference type="EnsemblBacteria" id="AFH42725">
        <property type="protein sequence ID" value="AFH42725"/>
        <property type="gene ID" value="FFONT_0737"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0737"/>
    <dbReference type="eggNOG" id="arCOG04327">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OMA" id="ARERWVT"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="96" mass="10917" checksum="90D4D5F754CE0E4A" modified="2012-06-13" version="1">MINAMPKKREGGEEKPKARTMTEQAEMNVSVPDELLKRAERELKQVEYITPFMLSQKLSVSISTSKKILKMLAEKGTLKTIVQNRRAPIYVPADKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A195</accession>
    <name>I0A195_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SufBD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0764"/>
    <dbReference type="EnsemblBacteria" id="AFH42752">
        <property type="protein sequence ID" value="AFH42752"/>
        <property type="gene ID" value="FFONT_0764"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0764"/>
    <dbReference type="eggNOG" id="arCOG01715">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_736928_0_0_2"/>
    <dbReference type="OMA" id="MSHHRED"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SUF_FeS_clus_asmbl_SufBD"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR43575"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01458">
        <property type="entry name" value="SUFBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101960">
        <property type="entry name" value="SSF101960"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="378" mass="42232" checksum="0E84B32D17623FED" modified="2012-06-13" version="1">MASSELELEKMPYQKFKDSPTIKYYTDWATFDELLGYMPEGTVGWIDIGTLKKSPTILLKPDGFEYSGINDIGVEKFSRNALKLYDLSEGKVYAKHFLRIDKYISLLIKEGEKRNVKLAIIPPKKGSSSHHLSIKLERSASLNLEVIYAPISESSLSSFTLEIDGEGENKIKILNLVKAPNNSPFFYETRILGRGKDDISVRTATSGGIIHNRADIVILGSMSKANIKALSLVTNNNRADLTTNILNDSSQGIAEILVRGINAGGEIVHRGTLKAETNSIESENKLRSYLIKTSKNSINHSVPILEITTNLIKTAEHSTDISDIPEDILFYLSSRGLKREEAVFLLTQSMLIDMVEDLFENSNEAIEWSNNFLKNIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A198</accession>
    <name>I0A198_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0767"/>
    <dbReference type="EnsemblBacteria" id="AFH42755">
        <property type="protein sequence ID" value="AFH42755"/>
        <property type="gene ID" value="FFONT_0767"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0767"/>
    <dbReference type="eggNOG" id="arCOG07221">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1850542_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="138" mass="16168" checksum="6F05C0FE5A15B7E4" modified="2012-06-13" version="1">MNENKENYVKKLSFIIDDILANNIEKKCEICGKKERKNKCRICGREVCNDCYNKEKGMCIVCSETLCEICKRRNAVERCQICGKLVCPDCMVRIDKSRVVCRDCYEKLGLDGVRRIIEDKAISENLKMKKFFQEFCEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1C2</accession>
    <name>I0A1C2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0791"/>
    <dbReference type="EnsemblBacteria" id="AFH42779">
        <property type="protein sequence ID" value="AFH42779"/>
        <property type="gene ID" value="FFONT_0791"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0791"/>
    <dbReference type="eggNOG" id="arCOG01474">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_4_2"/>
    <dbReference type="OMA" id="IEMHLIV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="216"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="292" mass="33092" checksum="36B3500CFE15E6C7" modified="2012-06-13" version="1">MFKFKDVREAEKAEAVVSIIINVALWVIRLIAGILLNSIALITDAWHGLSDALTSLGVLIFSKIASKPPDKEHPFGHGRAADLGSFLIGIMLFIIGFYFLYDGIQGLMTEREIVYSYLGLSLIVTVITIFIKIFNYLYAQKLGKDYNSNLCKTDALHHKLDALVTAVVVVGLSMYYFFNIPKMDSILTIFVSSLIIYEGGETVYGIANILMDKNFEDISEEIKSILKEFKDIEKISDIRVRSIGSYYYVELNISLKKDMKLSRAHEISDKVEDELKKRIPQILEVHIHEEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1C5</accession>
    <name>I0A1C5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase Mre11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0794</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0794"/>
    <dbReference type="EnsemblBacteria" id="AFH42782">
        <property type="protein sequence ID" value="AFH42782"/>
        <property type="gene ID" value="FFONT_0794"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0794"/>
    <dbReference type="eggNOG" id="arCOG00397">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026621_5_2_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="4"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="419" mass="48296" checksum="6FEF69C473F30356" modified="2012-06-13" version="1">MVLIAHAADLHFGHTRRAEDIESSLREMIDILKKEHLKFLIIAGDVFDRDRPENIILKRFHEIMKDFYDSGGRVFAVRGDHDTPKASKKGNPLDTISTYIGGSFLNLEINLNGNPAYIIEESGEKIFLYSFPFVPKAVRRREDYLNIFKKIEKNAKENGGKSILIGHFPISELFPFEEGYSLSELPDYINYYALGHLHFRIIEKVKRGILAYPSSIEILNVNEINDWKKNGKGFYIVDFSEDVPNVQKVNLNIRPMELFRGEDVKLLIEEVKRYLSGNFSKSPYIKIELKVDRGKKREARIAIRSSINKEKVYELEIEIREKEAKDLFLNNERVRKESESVDIITSRLGDKNLALLLLELKECAIESKDFEKECNEILNSLFQNPTIKKISGSPCIEGVSQFLTKQEGENKNGLLSYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1D4</accession>
    <name>I0A1D4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0803"/>
    <dbReference type="EnsemblBacteria" id="AFH42791">
        <property type="protein sequence ID" value="AFH42791"/>
        <property type="gene ID" value="FFONT_0803"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0803"/>
    <dbReference type="eggNOG" id="arCOG04469">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028170_0_0_2"/>
    <dbReference type="OMA" id="HIALRKM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002823">
        <property type="entry name" value="DUF112_TM"/>
    </dbReference>
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        <property type="entry name" value="TctA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
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        <location>
            <begin position="69"/>
            <end position="87"/>
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        <location>
            <begin position="108"/>
            <end position="128"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="217"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="456" mass="48593" checksum="70B86965539054AC" modified="2012-06-13" version="1">MDVASIIIYSTVLAAISSIIYIFIGILPGTDETATMAPVALALLLAGLDPIVVLAWFMASIVAFKIADAIPVALAGIPGGVMAVPQVPDALVAKEHGLADTLLRKGNSAALVAAITVTIFVLVVSYVLMPLGAWLNTTDLIMSVKVARWFWLILGGVIFLAVTSKNKLLGLFAIPAFAILVQGIRGVYGKPVSISLFLGITIGPIIYEIFTSLNGELRKSMEKKGKKIVKLSKVGKISINPFKNLTKEEILHIFIWSPISSILATVMSPVGLTILIGDTLRETKRNRLQGSVLAYTVREGIKLGTYIGGTLIPLLVIGAATGPMSAGPAAPFFQMIPTINDKPFHYILTHYSYSFIVLIAIYSVIISLAISYPLIVKYSRRLTLFVFNRISAESLYGLFVAIAVLLAYYDAGIPGIFGMLLVSVISGALNKLGVSLGVLFMTLVGASIIVALLAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1F4</accession>
    <name>I0A1F4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Translation initiation factor 2 subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">aIF2-beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">eIF-2-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
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        <name evidence="11" type="ordered locus">FFONT_0823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 9">Heterotrimer composed of an alpha, a beta and a gamma chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0823"/>
    <dbReference type="EnsemblBacteria" id="AFH42811">
        <property type="protein sequence ID" value="AFH42811"/>
        <property type="gene ID" value="FFONT_0823"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0823"/>
    <dbReference type="eggNOG" id="arCOG01640">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="GKPDTRL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00232">
        <property type="entry name" value="eIF_2_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004458">
        <property type="entry name" value="TIF2_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="PTHR23001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="eIF2B_5"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF75689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF2B_5" evidence="10">
        <location>
            <begin position="30"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011243"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="145" mass="16536" checksum="115F4CFB7FADF2B9" modified="2012-06-13" version="1">MENVDDNYFKNYQNLLERLYKKVPAPASSGERFEPPKLIAHQMGNQTVIRNFREVADKLRREPELLARYFLKGLATSGNYDRESGTLLLNSKLNVETLNNILNKFIESYVICPTCGRPDTVIIKKGKIWILKCEACGAEGPVKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1H3</accession>
    <name>I0A1H3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-phosphopantoate--beta-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphopantothenate synthetase</fullName>
            <shortName evidence="1">PPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27930"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:61294"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeal phosphopantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.36" evidence="1"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0842"/>
    <dbReference type="EnsemblBacteria" id="AFH42830">
        <property type="protein sequence ID" value="AFH42830"/>
        <property type="gene ID" value="FFONT_0842"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0842"/>
    <dbReference type="eggNOG" id="arCOG04262">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078701_0_0_2"/>
    <dbReference type="OMA" id="PKSHPRY"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016881">
        <property type="term" value="F:acid-amino acid ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02224">
        <property type="entry name" value="PPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002855">
        <property type="entry name" value="PPS/PS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038138">
        <property type="entry name" value="PPS/PS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40695">
        <property type="entry name" value="PTHR40695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02006">
        <property type="entry name" value="PPS_PS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004853">
        <property type="entry name" value="UCP004853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="180"/>
            <end position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="198"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="256" mass="29102" checksum="D56B0B448F6950FF" modified="2012-06-13" version="1">MEYVPRDHPRYRSLMEREKIIEGFKNGIVVINGLISQGRGEAFDYIIGEKTIPLAEDSIEVAVAMLLLSNYPVISVNGNAAALVPDEIINLSNIIDAKIEVNLFYRTEERVKKIVDFLKERGAKEVLGLEYVEGIPGLSSERRKVDPRGILKADVVLVMLEDGDRTEALKKIGKRVIAIDLNPFSRTSMAADVSIMDNVTRAIPLMIDKARIMKKLPKEELKKKISNYNNRRRLGEYIIYIKERLENEAKRLMSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1H4</accession>
    <name>I0A1H4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0843</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0843"/>
    <dbReference type="EnsemblBacteria" id="AFH42831">
        <property type="protein sequence ID" value="AFH42831"/>
        <property type="gene ID" value="FFONT_0843"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0843"/>
    <dbReference type="eggNOG" id="arCOG01097">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095256_1_0_2"/>
    <dbReference type="OMA" id="AYAEFVH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="184" mass="20832" checksum="236030874044B78C" modified="2012-06-13" version="1">MVRAMTKDALIAAFGGESMAHMRYQIFADIAEKEGFKNVSRLFRGIAYAEKVHASNHYNALREYNEDQIAHSGVPIGPGNTSKNLELAIRGEEFEVKEMYPVYIDIAKMQGENEALKSFNFALKAEEIHAELYKQAKKDVDSGKDFNLKGRVYVCPVCGYTYVGEEPPERCPICGAKREMFRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1I3</accession>
    <name>I0A1I3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyoxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0852"/>
    <dbReference type="EnsemblBacteria" id="AFH42840">
        <property type="protein sequence ID" value="AFH42840"/>
        <property type="gene ID" value="FFONT_0852"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0852"/>
    <dbReference type="eggNOG" id="arCOG01755">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_2_2"/>
    <dbReference type="OMA" id="KMKPNCI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="6"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="110"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="337" mass="37911" checksum="79F4BD1D77A126D6" modified="2012-06-13" version="1">MSKPRVYITREIPSVGLELIKKYFEVEVWPEYWAPPREILLEKVKNIDGLVSLLTDKIDAELLDKAKNLKIISQYAVGYDNIDLSYATKKGVYVTNTPGVLTDSTADLTFALILAITRRIVEADKFVRDGSWERSRTGWHPLMLLGMELKGKTLGIIGMGRIGRAVAQRALGFEMNILYYDVNKLPPEEEKRLNAQYASLEELLEKSDVVSIHTDLNKSTYHLINEERLKRMKKTAYIINVARGPIIDTQALVKALKEGWIAGAGLDVFESEPLPSNHELTKLNNVVIVPHIGSATHEARNGMAMKVATNLIEFLNGRVPPDLVNKEVVNVRKPGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1I5</accession>
    <name>I0A1I5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0215 protein FFONT_0854</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0215 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0854"/>
    <dbReference type="EnsemblBacteria" id="AFH42842">
        <property type="protein sequence ID" value="AFH42842"/>
        <property type="gene ID" value="FFONT_0854"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0854"/>
    <dbReference type="eggNOG" id="arCOG00928">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095956_1_1_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00582">
        <property type="entry name" value="UPF0215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002802">
        <property type="entry name" value="DUF99"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39518">
        <property type="entry name" value="PTHR39518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01949">
        <property type="entry name" value="DUF99"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006380">
        <property type="entry name" value="UCP006380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="195" mass="22457" checksum="ABA10AE703DFF7DE" modified="2012-06-13" version="1">MLINKIAIGIDDGHFEKGKNKNTVIVGVKFNGFNPVSAFIRKIGVDRTDATERGIELIQSATEGINSKDVVVFLDGVTYAGFNFIDPEEIKEKTKMEIIAIFSRKPNQDKIENALRLHFSDWEYRWEHIYKVIKNVRSIVNFRGKLYFFTTIENAKDAEFLIESYQLISKLPEPIRVAHIIAKEISFFLIKENTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1J5</accession>
    <name>I0A1J5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Geranylgeranylglyceryl phosphate synthase</fullName>
            <shortName evidence="9">GGGP synthase</shortName>
            <shortName evidence="9">GGGPS</shortName>
            <ecNumber evidence="9">2.5.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">(S)-3-O-geranylgeranylglyceryl phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Phosphoglycerol geranylgeranyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FFONT_0864</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>(2E,6E,10E)-geranylgeranyl diphosphate + sn-glycerol 1-phosphate = diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23404"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57677"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="9">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GGGP/HepGP synthase family. Group II subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.41" evidence="9"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0864"/>
    <dbReference type="EnsemblBacteria" id="AFH42852">
        <property type="protein sequence ID" value="AFH42852"/>
        <property type="gene ID" value="FFONT_0864"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0864"/>
    <dbReference type="eggNOG" id="arCOG01085">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068610_0_0_2"/>
    <dbReference type="OMA" id="ADAIFFM"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047294">
        <property type="term" value="F:phosphoglycerol geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02812">
        <property type="entry name" value="PcrB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00112">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038597">
        <property type="entry name" value="GGGP/HepGP_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008205">
        <property type="entry name" value="GGGP_HepGP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010946">
        <property type="entry name" value="GGGP_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01884">
        <property type="entry name" value="PcrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01769">
        <property type="entry name" value="GGGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01768">
        <property type="entry name" value="GGGP-family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="207"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glycerol-1-phosphate binding" evidence="9">
        <location>
            <begin position="229"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="250" mass="27008" checksum="5F64993C7EEC62A5" modified="2012-06-13" version="1">MKVLKRMKVKEYLEERRKFGTLHFTLIDPHKTNAENAEKIASILKDIGTDAFLLGGSIGVDPIEASEIALKLKETGLPVIIFPGDLTNIVKTADAILFMSLLNSENPYHIIGAQVQGAFLVKKYGLETLPTAYIVIGYGGAAGYMGMARPIPWDQVNISIAYALAANMLGMRYIYLEAGSGSPQHIPPEVIKSIKKTVPEAFLIVGGGIRTKEAALSVAEAGADAIVTGNIVEEDIKKAEEIIKAIKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1J9</accession>
    <name>I0A1J9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PadR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0868"/>
    <dbReference type="EnsemblBacteria" id="AFH42856">
        <property type="protein sequence ID" value="AFH42856"/>
        <property type="gene ID" value="FFONT_0868"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0868"/>
    <dbReference type="eggNOG" id="arCOG00001">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063440_9_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005149">
        <property type="entry name" value="Tscrpt_reg_PadR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03551">
        <property type="entry name" value="PadR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PadR" evidence="1">
        <location>
            <begin position="40"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="110" mass="12953" checksum="54C1740860022B91" modified="2012-06-13" version="1">MEKESKSRAFERLKKKIENEVLWIYVSYVLIKKGALSINEIKKEINDLFGIKVNTLYLYSIIYRMEEEGLIVKVEGDPKSTYTITPEGELTYKKALVFLEEKLLQLKKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1K8</accession>
    <name>I0A1K8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyrrolidone-carboxylate peptidase</fullName>
            <ecNumber evidence="9">3.4.19.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">5-oxoprolyl-peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyroglutamyl-peptidase I</fullName>
            <shortName evidence="9">PGP-I</shortName>
            <shortName evidence="9">Pyrase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcp</name>
        <name evidence="12" type="ordered locus">FFONT_0877</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Removes 5-oxoproline from various penultimate amino acid residues except L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro.</text>
            <dbReference type="EC" id="3.4.19.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the peptidase C15 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.3" evidence="9"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0877"/>
    <dbReference type="MEROPS" id="C15.001"/>
    <dbReference type="EnsemblBacteria" id="AFH42865">
        <property type="protein sequence ID" value="AFH42865"/>
        <property type="gene ID" value="FFONT_0877"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0877"/>
    <dbReference type="eggNOG" id="arCOG05850">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043960_4_0_2"/>
    <dbReference type="OMA" id="KLAYNHK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016920">
        <property type="term" value="F:pyroglutamyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00501">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00417">
        <property type="entry name" value="Pyrrolid_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000816">
        <property type="entry name" value="Peptidase_C15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029762">
        <property type="entry name" value="PGP-I_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033694">
        <property type="entry name" value="PGPEP1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033693">
        <property type="entry name" value="PGPEP1_Glu_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PTHR23402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01470">
        <property type="entry name" value="Peptidase_C15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015592">
        <property type="entry name" value="Prld-crbxl_pptds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00706">
        <property type="entry name" value="PYROGLUPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="SSF53182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00504">
        <property type="entry name" value="pyro_pdase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01334">
        <property type="entry name" value="PYRASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01333">
        <property type="entry name" value="PYRASE_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="9 10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" evidence="9 11">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH42865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="222" mass="24836" checksum="A50E853D78226DB3" modified="2012-06-13" version="1">MEKYKILVTGFEPFGGYKQNPSQIIAEHLPEKIEKEMPNVELQTAILPVAYKKAKDKLLTLLDSYKPDIVLSMGLWAGISYVTMERVAVNIMDARIPDNDGYQPIDEPIYTEGPNAYFSTLPIKSIVKRLKESGIPASVSNTAGTFLCNYVMYIALHSRATKGYPRRSGYMHVPLLPEQTASVKSEFGIPPSMSLENMIRAAIITLKVTVEKFYVGDEKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1L9</accession>
    <name>I0A1L9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0888</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="2">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0888"/>
    <dbReference type="EnsemblBacteria" id="AFH42876">
        <property type="protein sequence ID" value="AFH42876"/>
        <property type="gene ID" value="FFONT_0888"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0888"/>
    <dbReference type="eggNOG" id="arCOG01068">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_2"/>
    <dbReference type="OMA" id="DAKYGEW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="11"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="3">
        <location>
            <begin position="342"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="464" mass="51273" checksum="FB4B63A780E65B9E" modified="2012-06-13" version="1">MKVLSTIKKEFDVAIIGSGTGGYPGAIYLAQKGLKVAVIEENLTGGECTNYGCVPSKAIYQFAESIRTLKNISANSSYEWEKLIEWADNSVKGVRNGIESLFDSYDNIAYFKGKGVLKAKNKISIIEENNSEIDAKNVILATGTDPSKIPVADFDKKGIISNREVFSLKEKPNSMLIVGGGVIGVELANMFSSLGIQTYLVELKERILPFLDKDVSQAIKGYLVEKGVKVMERTSLKGVSKVSENYQVLLSNDEKLEVDKVIISTGRSPKTKNIGLENLGIKIDERGFIKVNEKLETNASGIYATGDVVGGPLLAHKAIIESISAAKWISENNGFHVDYYSIPQVIFSGLEIAWIGMGENELNSKGINYEKIKLPIYYLAAVRIRNERRSFIKLLLDKESKKIYGIEIVAPHASEVISSYLPLYLNKITIEEASKITYPHLTVSESIRDIAEYLLGEPIHMIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1N2</accession>
    <name>I0A1N2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pyridoxal phosphate-dependent aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0901</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0901"/>
    <dbReference type="EnsemblBacteria" id="AFH42889">
        <property type="protein sequence ID" value="AFH42889"/>
        <property type="gene ID" value="FFONT_0901"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0901"/>
    <dbReference type="eggNOG" id="arCOG00915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OMA" id="FWGWQAH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="205"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="466" mass="52085" checksum="F8249CF8B9F1422F" modified="2012-06-13" version="1">MGKMKWDDILKFTSKKIEKNLEIVKLDEEYISSASALKYFPIAITKTEGSKVWDADGNEYIDFLTSAAVYNIGHRHPNVVNAIKEQTEKVLNYTIAYFYEENPVKLAKYLIEITPGSFEKKVAFGFSGSDSVDIALKVARAYKKKKGIISFYGSYHGTTYGALSATGIIDPQLKDTVFPSKDVLFVEYPDPYRNPWNIDGYEDPLELSNIALENIEKKIKNVNEDVSAVIFEPIQGDAGVIVPPKGFIEGLRKLAQNYNILLIDEEVQSGMGRTGKWWAIEHYNIEPDILISAKALGGGMPISAVIGKKEIIDSIPPPLLVFTHTGHAINASAAIATIETIKKEGLIKKAYELGNYAIKRFREMSEKFSIIGDIRGKGLMIGIDIVKNTKLKEPDKSLALKICWRAWEKGLILITFGKYGNVLRIAPPLNIDINELDKGIEIIEESIKDVLNGKVSDEILKYLRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1N4</accession>
    <name>I0A1N4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exopeptidase, family M19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0903"/>
    <dbReference type="EnsemblBacteria" id="AFH42891">
        <property type="protein sequence ID" value="AFH42891"/>
        <property type="gene ID" value="FFONT_0903"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0903"/>
    <dbReference type="eggNOG" id="arCOG04083">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_2_1_2"/>
    <dbReference type="OMA" id="YAMGDDP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="349" mass="39138" checksum="98866571CF31F124" modified="2012-06-13" version="1">MGGKMGNLFESLPIIDHHEDVSSYFLYPGEGGAPYGNFGEDIPGREADIPKYKRGKVRCVFSAIFPGIETFRPEESKELEKIYGKWLPATGYRVPQALLWEHVSIYYKLSDAYKIKIVERVEDVESCIKEERLCFVLHLEGAEALDEPYDLVLLKKIGLRSIGITWNYVNKYGTGCGAKKDTGLSEMGEELVKMANRLGIIVDLAHASKKTSVEAIEISKRPVMISHANVRKLIDRSRNVDDELLELLHKNGGILGFSVIGPLISNRPRPTLDELVDHVMYVYENYGAENIAIGTDFLGLMGLPSPEGLESVDKLPNLLEKLAEKGMNDSDVRKVAYENSLRLMRNNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Q8</accession>
    <name>I0A1Q8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal flagellar protein FlaF, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0927</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0927"/>
    <dbReference type="EnsemblBacteria" id="AFH42915">
        <property type="protein sequence ID" value="AFH42915"/>
        <property type="gene ID" value="FFONT_0927"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0927"/>
    <dbReference type="eggNOG" id="arCOG01824">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1559410_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="171" mass="18842" checksum="34CF4466A8B4EA4A" modified="2012-06-13" version="1">MGFSVTASGIIVMAVLIISVLSMVSVIMKGYGMITSSIERKALSSVRSSLSITYITNVTVNQNNLTMTFIFSNNGSWSFWDFDHFDFILIYTSNKTNSESSKVLVYGRDWNITAILINGGLVERFNGVVDPSESGIVYASLPPDISFSQPITIVFVNQYGFKASYTFYSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1V3</accession>
    <name>I0A1V3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42960">
        <property type="protein sequence ID" value="AFH42960"/>
        <property type="gene ID" value="FFONT_0972"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0972"/>
    <dbReference type="eggNOG" id="arCOG01009">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3210604_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="44" mass="5056" checksum="0F29F2571B1341FF" modified="2012-06-13" version="1">MASAIDRLVEDKIFQSRSEAIRYAIGSLISTHFNKKGKESWIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1V8</accession>
    <name>I0A1V8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Uridylate kinase</fullName>
            <shortName evidence="6">UK</shortName>
            <ecNumber evidence="6">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Uridine monophosphate kinase</fullName>
            <shortName evidence="6">UMP kinase</shortName>
            <shortName evidence="6">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pyrH</name>
        <name evidence="8" type="ordered locus">FFONT_0977</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UMP kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0977"/>
    <dbReference type="EnsemblBacteria" id="AFH42965">
        <property type="protein sequence ID" value="AFH42965"/>
        <property type="gene ID" value="FFONT_0977"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0977"/>
    <dbReference type="eggNOG" id="arCOG00858">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079546_0_0_2"/>
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</entry>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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            <dbReference type="Pfam" id="PF04010"/>
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            <dbReference type="EMBL" id="AFH43008.1"/>
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            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="227" mass="26170" checksum="DCCCBBF645F98974" modified="2012-06-13" version="1">MKDRIATYIKMVENALEQTECQKSSLNKEESDLINLAKLYLEDSKYYLEKEDLVTSLATISYAEGLLDALARLGKLKIEWKREKRKKVLITGTFDILHEGHIRLIEEASKLGDVYVIVSRDVNAKKNKGREVIFPENSRLKIVSSIKNVKMAMLGDENDYLKKVIEVSPDIIVLGPDQKFGEEQLKEELKKRGLNNVEVIRLKNRFNDFYPNSSTQVILEVMKKFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A203</accession>
    <name>I0A203_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Indolepyruvate:ferredoxin oxidoreductase subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_1022</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1022"/>
    <dbReference type="EnsemblBacteria" id="AFH43010">
        <property type="protein sequence ID" value="AFH43010"/>
        <property type="gene ID" value="FFONT_1022"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1022"/>
    <dbReference type="eggNOG" id="arCOG01602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_1_1_2"/>
    <dbReference type="OMA" id="HGMSQRF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="POR" evidence="3">
        <location>
            <begin position="12"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="203" mass="22446" checksum="9187043982CFF5DA" modified="2012-06-13" version="1">MKEYNIIISGVGGQGVITIANLIGLAAFKQGIKARVGEIHGLSQRFGSVFTHVRIGEDVYSSIVPLGRGDLLISLEAIETLRYLKYMKKDGLILMNTLMTEPFKTISVDPKIADINEIKKMMKSAFDGKILIINGNELTEKLKNSLLLNTAIIGIALTIPGFPLKEESIKASIEEMFDRKYVELNIRALEVGMNYGKEILSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A206</accession>
    <name>I0A206_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proliferating-cell nucleolar antigen p120-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1025"/>
    <dbReference type="EnsemblBacteria" id="AFH43013">
        <property type="protein sequence ID" value="AFH43013"/>
        <property type="gene ID" value="FFONT_1025"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1025"/>
    <dbReference type="eggNOG" id="arCOG00973">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_7_0_2"/>
    <dbReference type="OMA" id="EPEENEF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="4">
        <location>
            <begin position="45"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="331" mass="37896" checksum="76279DA6EDF9872E" modified="2012-06-13" version="1">MYINKKLFDIQITKEAVEIAEKFGISPFMAQRYIMFMGDKEAIEYLISAEKGIEKSFRCNSILVKDCNVVERSLTEKGFILEKTPYLNYAYYIKREPFSIGSTVEHLSGKIYVQGVGSMLASEVLSPVEDDKVVDMAAAPGGKTTHMAQLMKNKGIILSIDINRERIWKLRVNIERLNAKNVYVLRTDALKINGLDEYFDKVMLDAPCTGEGLIVYKKERKFSKGIEDYKKMIPLQISMLKKAFKLLKRGGKILYSTCSIAPEENEYVISQVLNELKDIEILPTRYNGVKGNEGLPEYNDIFFGDELKNCLRLYPNTDKTEGFFLCLMRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I0A208</accession>
    <name>I0A208_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1027"/>
    <dbReference type="EnsemblBacteria" id="AFH43015">
        <property type="protein sequence ID" value="AFH43015"/>
        <property type="gene ID" value="FFONT_1027"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1027"/>
    <dbReference type="eggNOG" id="arCOG00980">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073526_1_0_2"/>
    <dbReference type="OMA" id="IREFHRH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040825">
        <property type="entry name" value="FKBP26_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18046">
        <property type="entry name" value="FKBP26_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="258" mass="29610" checksum="03C0FE67559F27CB" modified="2012-06-13" version="1">MYAMPFKEKDFILIDYTATVKETNTVVDTTNSEKAKESNIYDENKTYEPTLVIIGEGRVVKGLEEALQEMNEGEQKVIELPPSKAYGERDPNRLRRIPIREFKKGDVEPVPGKVVEINGVPALIRDVTGGRVLVDFNHPLAGKTIVYEVKVIKYLQNDDEKVKALLKRRLRPKNIDDYNIKISKEEGFVQIKIPETEMINPDIQLAKRALAREIFNYIEGIKKVEFIEEIIAPEKPKEETAEEKEKPSEEKPKEEAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A227</accession>
    <name>I0A227_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1046"/>
    <dbReference type="EnsemblBacteria" id="AFH43034">
        <property type="protein sequence ID" value="AFH43034"/>
        <property type="gene ID" value="FFONT_1046"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1046"/>
    <dbReference type="HOGENOM" id="CLU_2032764_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="121" mass="13667" checksum="27B496460B9F5FAB" modified="2012-06-13" version="1">MSKLRFPKGYFAYDPSVNEYKDIIECLKKKNISYDEVLITCEPIYGLFNLYKNDKIVESEKLMVVSRGSIIARSDYCGLGGYELLKDAWGEGVVINAEKLKSVNADSFLDAFIKSCVEKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I0A269</accession>
    <name>I0A269_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-archaeol synthase</fullName>
            <ecNumber evidence="6">2.7.7.67</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">carS</name>
        <name evidence="7" type="ordered locus">FFONT_1088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:25690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58837"/>
            <dbReference type="ChEBI" id="CHEBI:58838"/>
            <dbReference type="EC" id="2.7.7.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CDP-archaeol synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.67" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1088"/>
    <dbReference type="EnsemblBacteria" id="AFH43076">
        <property type="protein sequence ID" value="AFH43076"/>
        <property type="gene ID" value="FFONT_1088"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1088"/>
    <dbReference type="eggNOG" id="arCOG04106">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105710_0_0_2"/>
    <dbReference type="OMA" id="GKTWRGT"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043338">
        <property type="term" value="F:CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01117">
        <property type="entry name" value="CDP_archaeol_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032690">
        <property type="entry name" value="CarS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002726">
        <property type="entry name" value="CarS_archaea"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39650">
        <property type="entry name" value="PTHR39650"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01864">
        <property type="entry name" value="CarS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH43076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="173" mass="19191" checksum="09948D2094DAE256" modified="2012-06-13" version="1">MDILRILIDFLKIYIPPMVANGIPVVVSKFIKGRPLDRGKYLSDGKRILGDGKTVEGTTFAILTGTLMGAIIGILNYYSLQYCFTGFLGSLGGILGDITKSFFKRRIGIERGGMLPLVDQLDFYLGSTLFIYLCPICAHPSLDVFLFGIIIIPLLHLSTNYIAFKLHLKSVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A275</accession>
    <name>I0A275_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA primase small subunit PriS</fullName>
            <ecNumber evidence="10">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">priS</name>
        <name evidence="13" type="ordered locus">FFONT_1094</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.</text>
    </comment>
    <comment type="function">
        <text evidence="12">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of a small subunit (PriS) and a large subunit (PriL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="10"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1094"/>
    <dbReference type="EnsemblBacteria" id="AFH43082">
        <property type="protein sequence ID" value="AFH43082"/>
        <property type="gene ID" value="FFONT_1094"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1094"/>
    <dbReference type="eggNOG" id="arCOG04110">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056123_1_0_2"/>
    <dbReference type="OMA" id="GYHVHVR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00700">
        <property type="entry name" value="DNA_primase_sml_arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023639">
        <property type="entry name" value="DNA_primase_ssu_PriS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="PTHR10536"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 10 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 10 11" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 10 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH43082.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="389" mass="44176" checksum="01612644A4FF044B" modified="2012-06-13" version="1">MSLTSHQEKRKRSIDRKEWLFQKLSAYYEKAKLELPDDINSREFAVQPIDYKGYVRHLSFKSEDELRSFLLKNPPMHLYYSSAIYTFPEIDDMEKKGMIGSEIIFDIDADEVPGCESIEQLHACLNCGSLLYGKSIKKCTKCGSQNVIEVEPIPKECILKAGIEAKKLIKVLRKDFGFEKIKIYFSGNRGFHVHPKCDDEWLKLTSEERSMIIKYITGSGVNIERIIGLGESIKGKNMYIPNPKEPGWRGRLGEILYKKMNLNDEKKITFGEAEVLLGEKINLNDIMKMASISIDEKVTVDVHRLIRIPGSINGKLGLPVFEIGESELESFSINCSYSPFKEDEDVKMNVSMQNKEILGIKINSLKGDIIKIPGCLAFLFISKGIADPA</sequence>
</entry>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </evidence>
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    </evidence>
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    <sequence length="304" mass="34232" checksum="F5233BFBA29687FC" modified="2012-06-13" version="1">MKLLTFSIKGEKKVGLLTEKGVLDLPQAFKKVYKSNYAPDFFYSMKKLILMEKEAKKLIEEIEAKSLDLDLEGNIYLKKGEFKWEPPVLDSEKFLCVAVNYKQHGQESGLKPPSRPYFFPKFPTSLVGHEDNILKPKVSEKVDWEVELGVVIGKAGKYIKKDDADEHIFGYTIVNDITMRDWQFPPLGSLGLDWIGGKTMDLSTPVGPYIVTKDEIDNPNNLKLYLRVNGSIEQNGSTNDLIFNVEELIEWSSKGITLRPGDIISTGTPSGVGHSKNKYLKGGDEVEAEVEKIGILRNFVVEEL</sequence>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
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</entry>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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    <sequence length="95" mass="10839" checksum="6BCB9D2103CC1864" modified="2012-06-13" version="1">MKLTLGQNSIKDEIIESIISAGLLEDLISYLSKNGIDIDGIKKITDIDEEVLLKYAKEKGLLFESDPSQVLEKTDEYEDIEPYEQRPKTPPKNKR</sequence>
</entry>
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                <person name="Gumerov V.M."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="OMA" id="DKWYTKP"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="AFH43158.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="81" mass="9518" checksum="E94277E8F7D1DFBC" modified="2012-06-13" version="1">MADYLEQLKEQISVKLNAAGIKILPKEKMLRLVKDMEIIMTITDKGDYIELSYKGQTYKYDKWYSKPEHLAPIILRTLNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2F4</accession>
    <name>I0A2F4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acylphosphatase</fullName>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Gumerov V.M."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Kublanov I.V."/>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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    </reference>
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                <person name="Ravin N.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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                <person name="Kublanov I.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="65"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH43258.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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            <end position="159"/>
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        <location>
            <begin position="300"/>
            <end position="463"/>
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    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="469"/>
            <end position="536"/>
        </location>
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        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH43274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="563" mass="64697" checksum="795FA33725581B44" modified="2012-06-13" version="1"> </sequence>
</entry>
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        <submittedName>
            <fullName evidence="2">Flavoprotein</fullName>
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        <name evidence="2" type="ordered locus">FFONT_1302</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <end position="397"/>
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    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="AFH43290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="402" mass="45660" checksum="0AB52A781E362316" modified="2012-06-13" version="1">MNEKILVVNLLNFKPIKLTEGIYWVGVKDWSRKIFDAFAPLERGTSYNSYLVKGSTSVALIDTVESDFQSEFFEKLESVVNIKDIKYVIMNHAEPDHSGSIPVVMEKASDAKLVTTAFGAKLAKVFYHVPDERIKIVRDGDIIDLGGRTLKFIEAPMLHWPETMFTYLVEDGVLFSCDFFSAHLAEGIWDDDVSDIIEFSKEYWATIMMPFRTNAISALKKISNLKIKMIAPSHGPIIRHPEKILEKYNEWTEGKTDKKVLILYVSMYKHTESIARLLESEFFNRGINVKLYDLVQANLSEVSKNMADSSAIVLAVPTIIGSIHPIPFNYLYLLKLLKPPIKYAGVIITFGWGTSADKQIEELLKDSKIEILDTIKVNVNLSEDNKKQILSLVEKIEAKLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2W5</accession>
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        <recommendedName>
            <fullName evidence="6">30S ribosomal protein S27ae</fullName>
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    <gene>
        <name evidence="6" type="primary">rps27ae</name>
        <name evidence="8" type="ordered locus">FFONT_1334</name>
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
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            <name>Zn(2+)</name>
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    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH43322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH43322">
        <property type="protein sequence ID" value="AFH43322"/>
        <property type="gene ID" value="FFONT_1334"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1334"/>
    <dbReference type="eggNOG" id="arCOG04183">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_179743_1_0_2"/>
    <dbReference type="OMA" id="CGYTIFE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00777">
        <property type="entry name" value="Ribosomal_S27ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_S27a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022845">
        <property type="entry name" value="Ribosomal_S27ae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Ribosomal_S27" evidence="7">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH43322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="56" mass="6781" checksum="3C2EF6057F3A2A26" modified="2012-06-13" version="1">MSQVHNYYEYDYKTKTIKLKNKRCPRCGSIMGHYKEPTERWYCGSCGYTEFLEKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2W9</accession>
    <name>I0A2W9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exosome complex component Rrp41</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rrp41</name>
        <name evidence="9" type="ordered locus">FFONT_1338</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'-&gt;5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase PH family. Rrp41 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1338"/>
    <dbReference type="EnsemblBacteria" id="AFH43326">
        <property type="protein sequence ID" value="AFH43326"/>
        <property type="gene ID" value="FFONT_1338"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1338"/>
    <dbReference type="eggNOG" id="arCOG01575">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063514_0_0_2"/>
    <dbReference type="OMA" id="KGKGQGW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11366">
        <property type="entry name" value="RNase_PH_archRRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00591">
        <property type="entry name" value="Exosome_Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011807">
        <property type="entry name" value="Rrp41"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02065">
        <property type="entry name" value="ECX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3 5" id="KW-0271">Exosome</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase_PH" evidence="7">
        <location>
            <begin position="24"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="RNase_PH_C" evidence="8">
        <location>
            <begin position="156"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH43326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="246" mass="27173" checksum="47A9D7D005A59426" modified="2012-06-13" version="1">MSHNSNRKLIDENGLRVDGRRPDQLRPISMKVGILKNAQGSALVSYGKTQVMAAVYGPREALPRHMTLPDRAILRIRYHMAPFSTSERKSPAPTRREIELSKVIREALEATVFSELFPRTTIDVFIEVLQADGGTRTTSLTAASLALADAGIPMKDLIAGVAVGKVDGVLVLDINEIEDSTGQADMPVAIMPNLNKIVLLQLNGTLTRDEFNEALKMAQKAIKEIYIMQKEALREKYSSMEEVEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2X3</accession>
    <name>I0A2X3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1342"/>
    <dbReference type="EnsemblBacteria" id="AFH43330">
        <property type="protein sequence ID" value="AFH43330"/>
        <property type="gene ID" value="FFONT_1342"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1342"/>
    <dbReference type="eggNOG" id="arCOG04414">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2366082_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="95" mass="11036" checksum="8419364B57E29CF4" modified="2012-06-13" version="1">MEKKEEIEKISFSLEIHHENEKLLKAYFESLKPEADSLVNQKKGKVFVEYNAEEKKLILKMETETISDFKALMNSYLYLIKAINDSLNSATSSMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2X5</accession>
    <name>I0A2X5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Prefoldin subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">GimC subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pfdB</name>
        <name evidence="9" type="ordered locus">FFONT_1344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 7">Heterohexamer of two alpha and four beta subunits.</text>
    </comment>
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        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the prefoldin subunit beta family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH43332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_1344"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1344"/>
    <dbReference type="eggNOG" id="arCOG01342">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
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        <property type="entry name" value="PfdB"/>
    </dbReference>
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        <property type="entry name" value="Prefoldin"/>
    </dbReference>
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        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="gimC_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
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    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="9"/>
            <end position="36"/>
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    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="87"/>
            <end position="114"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011716"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00016304"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH43332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="131" mass="15273" checksum="7119B04E7EA5405B" modified="2012-06-13" version="1">MAEKVPPEIEQVAQQLDELQEKYNNLLNQRLIVESELKEINKLLETLNNIPPETKIYRSVGNIFFAEDRDKLVKELTEKKETDELIYERFKKDEEDLKKQISTLQEKLRGLLSKYYQKVSTPVTKTGSGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A303</accession>
    <name>I0A303_FERFK</name>
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        <recommendedName>
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        </recommendedName>
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        <name evidence="4" type="ordered locus">FFONT_1372</name>
    </gene>
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Skryabin K.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <cofactor evidence="2">
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            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="3">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="170" mass="18839" checksum="44B2276C19D7B75B" modified="2012-06-13" version="1">MKIGIISDTHDNMKNISMFLEIMKSHEVELLIHLGDFSSPFAFKSIFSSYQNRGYAVFGNNDGDRVVLTKMAMRMGIEVAESVNPVSIGGRRFFLMHGFGSPELTSEIAEAVARSGKYDYVLFGHTHSLRISQMERALLINPGEASGALTQKATAVILEIPENRVEVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ43</accession>
    <name>H9ZZ43_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccaceae</taxon>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42000">
        <property type="protein sequence ID" value="AFH42000"/>
        <property type="gene ID" value="FFONT_0004"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0004"/>
    <dbReference type="HOGENOM" id="CLU_3245195_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="42" mass="4760" checksum="E2761DF50ED8462E" modified="2012-06-13" version="1">MEKNITADTVNRTTSEEVAFSIKNLDGESFVYLVTNFIDFEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ77</accession>
    <name>H9ZZ77_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0038"/>
    <dbReference type="EnsemblBacteria" id="AFH42034">
        <property type="protein sequence ID" value="AFH42034"/>
        <property type="gene ID" value="FFONT_0038"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0038"/>
    <dbReference type="eggNOG" id="arCOG02165">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG05201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_663241_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="50"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="414" mass="45687" checksum="AFBA615CD6D00153" modified="2012-06-13" version="1">MYVLAKKIFSKGSLSILISILLLILLTGFASYLYQLTSSSQTPQNTSGGSSSVQQSLENALRTISDLQQKLFYYNSSLSQLNQTYIETIAQLQQMNQNLTSTIEILNSSLASCNGNLSSLNETYSSLLSSYSQLMNEYSSLNASYSSLKANYSQLLTKMSELNETYSYAISELSSLNTSYANLLSQLSTISQLSFERGNPGAQLEAFFDYNSPAVISAMRSAVGNETTPYIGLYRLYNYVERSIRLNYDTPFLVVNQSGGSASFYLRELYFENATEVLNNGYGDAKDQALLLSTLYASYLSNYLNTSMPPIYMVLLNGTGYSKYPYWGFTLIIEGSGKVSLLDPAAAELAGINYQEFVQVDASGAYSAVTSYINRLNSLGLVYPNVVCMVGPTGFYWVNGTINDFLGLLYKLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ88</accession>
    <name>H9ZZ88_FERFK</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">FFONT_0050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0050"/>
    <dbReference type="EnsemblBacteria" id="AFH42045">
        <property type="protein sequence ID" value="AFH42045"/>
        <property type="gene ID" value="FFONT_0050"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0050"/>
    <dbReference type="eggNOG" id="arCOG13652">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_396203_0_0_2"/>
    <dbReference type="OMA" id="CFAHESE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="695" mass="77491" checksum="D5571260BE728985" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZE3</accession>
    <name>H9ZZE3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0107"/>
    <dbReference type="EnsemblBacteria" id="AFH42100">
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        <property type="gene ID" value="FFONT_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0107"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="82" mass="9008" checksum="68EF3838EC8C98A4" modified="2012-06-13" version="1">MEELEGRKLLDPFAGFGSIPLEGMRFGSNATAVELLPTAYVFLKGDVGISGSEAKQLEIEDIVRSFNDSRQLNNSIEYKLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZH0</accession>
    <name>H9ZZH0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0135"/>
    <dbReference type="EnsemblBacteria" id="AFH42127">
        <property type="protein sequence ID" value="AFH42127"/>
        <property type="gene ID" value="FFONT_0135"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0135"/>
    <dbReference type="HOGENOM" id="CLU_2190923_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="108" mass="12077" checksum="CB4FF19743CEE5E3" modified="2012-06-13" version="1">MNKITLYRDFSISGVKAERMLKEAVLGIALKYGLKTEFTTVLIPGESPEENEVKINEYRISANKISNASGTDEIEDLLLNILSEPYFSKVLSSSIEEGKNLERGLIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZJ0</accession>
    <name>H9ZZJ0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoesterase, DHHA1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0155</name>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0155"/>
    <dbReference type="EnsemblBacteria" id="AFH42147">
        <property type="protein sequence ID" value="AFH42147"/>
        <property type="gene ID" value="FFONT_0155"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0155"/>
    <dbReference type="eggNOG" id="arCOG00423">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076809_0_0_2"/>
    <dbReference type="OMA" id="WYDHHQW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA1" evidence="1">
        <location>
            <begin position="200"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="332" mass="38038" checksum="06A34F4125072AB3" modified="2012-06-13" version="1">MRNFKLISITHTDLDGVGSSSLYIRNTKPESYKVIFVEPYQLLKAVKSIAKSDESFDELVITDIGPNASTIKEVERALEKISREKGARIRWFDHHIWNNEWKDDLIKQGVDLRVDENHCATEVVYRNLNTDDIFSYMLSKSVCSADLWIFNDWAAPFLVRFVGNGRGKKWLEYVHSIFVKSPSFETLIEASKNKAVEVFDREIELMGFYREKAEDINIEGIKLTFVFKSHNDLSTSMLAQYLMSVRNSDIVVVVDKRGKYEFRSKKCNVREIAFKLGGGGHPEASGAPFPNFLTLLMKMKLYGLAVDLAKKKLLNTVKEVSCIPFNVIKKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZK6</accession>
    <name>H9ZZK6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="411" mass="45068" checksum="EFC63D84E2093B2C" modified="2012-06-13" version="1">MENLKEDLEDFLKMNLESIFTLTPARPVTYFGVGAIRMISEISKNLKSKGIDRAIIVTDPIVWQSTKVEQYIKPALEENGIEFTIYDKVRPNPTYASCDELANIAREFNAKVFITVGGGSHNDTAKTAAALLKNPGKTAKDLYEKIILINEAIPVVSINTTHGTGSELDKYAVAQSDGGYKPAIAGPGLYPVFAIEDPALTLTLPKRQTLSTALDAFHHSFEAATTKTRNPYSTLLSKTAIRLIAKWLPVAANEPNNIAARYWLMYASAIAGISFDIASLHLTHTLEHPMSALNPKTPHGIGLTAIFPAVLNVTYKIFPELSADLLSSIIPDLKGVPGEAEYAEREIEKWFASIGVPDKLTDLGFTDKDVDRLVENAITSPMTPLMAATSPVEVTKEVVRFIYERSLRPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZM3</accession>
    <name>H9ZZM3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gamma-glutamyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0189"/>
    <dbReference type="EnsemblBacteria" id="AFH42180">
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        <property type="gene ID" value="FFONT_0189"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="MFCLFYD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="514" mass="56877" checksum="6AB57D5AC0F440E9" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZQ1</accession>
    <name>H9ZZQ1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0217</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0217"/>
    <dbReference type="EnsemblBacteria" id="AFH42208">
        <property type="protein sequence ID" value="AFH42208"/>
        <property type="gene ID" value="FFONT_0217"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0217"/>
    <dbReference type="eggNOG" id="arCOG00953">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058377_0_0_2"/>
    <dbReference type="OMA" id="CIYCELG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040084">
        <property type="entry name" value="GTPase_Obg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01083">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RADICAL_SAM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="10"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="320" mass="36013" checksum="0C61DA7CA34FD4FD" modified="2012-06-13" version="1">MPMPKYTFGPIISRRLGLSLGVNNIPYKTCSYSCIYCQLGRTENFSIERREFYNWKEIVNDVERTVNELNGKVDYITFVPDGEPLLDKNIGIEISEIKKRVSPKVAVITNSSLLYLEGARSDLSESDLASVKVDATREDVWRRINRPHPKLSLSSILDGIKEFSKTYRGKLITETMLVDGVNSETKSIEEVASFINSINPAKAYISIPVRPPAEQFVKSPSPDKLVEAHEIFKRILGEEKVELLNLPEPPPPSAHGSSEDWILSVTSVHPQKLEYALNALSGITNDPEGVIARLEAEGMIKTVEYAGSKFIVRWFENRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZQ8</accession>
    <name>H9ZZQ8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0224</name>
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    <organism evidence="1 2">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0224"/>
    <dbReference type="EnsemblBacteria" id="AFH42215">
        <property type="protein sequence ID" value="AFH42215"/>
        <property type="gene ID" value="FFONT_0224"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0224"/>
    <dbReference type="eggNOG" id="arCOG11242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1840478_0_0_2"/>
    <dbReference type="OMA" id="ITFQATR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="139" mass="15599" checksum="710B6C23D3E0D45F" modified="2012-06-13" version="1">MTNAILLVIALLFICAFAWSYYKMSVLSNIANLNYSESLESNKALAIPSMSYVTLNYTLPYAGYLKISYSSTSAIYIWIGSNFSQQFPDGNYFSRYPPQRESSSGTFVVPVLPGEVYVTIYNPSIFNGVALTISIEYHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZR9</accession>
    <name>H9ZZR9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0235"/>
    <dbReference type="EnsemblBacteria" id="AFH42226">
        <property type="protein sequence ID" value="AFH42226"/>
        <property type="gene ID" value="FFONT_0235"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0235"/>
    <dbReference type="eggNOG" id="arCOG04252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005281_4_1_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="321" mass="36814" checksum="FC05DB09B8179809" modified="2012-06-13" version="1">MIYERIGINVFLTNSEGIEAGDFLERCSDFIVIERSFPPTNNEGKFYAYFLVKSGLSTESAVKIILTLIHKGKAFYYGLKDSNSLSVQNIVLTEFVGKNLCFGGKARLIYQGKTDFIPKKGGFNSNIFAIKFPDSIDAEKTLEEIKKLKAFPNFFGHQRFGFHEPFNHEIAIKLLKDGKLNTRSWKGEFLAESLQSYIFNVCLSRIDFKEDYNSKMGILLGTRHKEALKKKVLLKDHYECSLEVAEELGILELIEGKDFLKYQLRPLFIKNPLIKYYKSKEKLIAIAKMPPGSYASLIIREVFKNDESWMNKKCVAEKVCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZS5</accession>
    <name>H9ZZS5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psmB</name>
        <name evidence="10" type="ordered locus">FFONT_0241</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0241"/>
    <dbReference type="EnsemblBacteria" id="AFH42232">
        <property type="protein sequence ID" value="AFH42232"/>
        <property type="gene ID" value="FFONT_0241"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0241"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OMA" id="RVSYGFY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005059525" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="7"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023352429" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="8"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="199" mass="21815" checksum="1820111AA8EA58BD" modified="2012-06-13" version="1">MVETFQGATVVGLKFSNGAVIAGEERMTYRTFIMSSQAKKVYLINERLGAGTAGLMGDTQNIIRIFREEIRYYETEIKSKMSTKSAAKLLSNILYSYRGFPLYGEFILAGIDDKKPTLVVLDPAGSVLEDEYMAIGTGGPVAIGVLEELYQQNIDEKTAIDLAIRAVKQGVRRDAMSGGSIDYVVISDRGSYEGSVKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZU0</accession>
    <name>H9ZZU0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FFONT_0256</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0256"/>
    <dbReference type="EnsemblBacteria" id="AFH42247">
        <property type="protein sequence ID" value="AFH42247"/>
        <property type="gene ID" value="FFONT_0256"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0256"/>
    <dbReference type="eggNOG" id="arCOG00412">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020279_3_0_2"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="9">
        <location>
            <begin position="275"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="552" mass="62521" checksum="717D0FCA89DC7F5C" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZU4</accession>
    <name>H9ZZU4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphomethylpyrimidine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0261"/>
    <dbReference type="EnsemblBacteria" id="AFH42251">
        <property type="protein sequence ID" value="AFH42251"/>
        <property type="gene ID" value="FFONT_0261"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0261"/>
    <dbReference type="eggNOG" id="arCOG00020">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG00021">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035788_0_0_2"/>
    <dbReference type="OMA" id="AWIEIPA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019293">
        <property type="entry name" value="ThiN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10120">
        <property type="entry name" value="ThiP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phos_pyr_kin" evidence="1">
        <location>
            <begin position="20"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="459" mass="50087" checksum="91F6041E444AD723" modified="2012-06-13" version="1">MKTPWKKPFPPRCLTIAGSDSGGGAGIQADLKTFTVHGVYGMVAITSITAQNTKEVRAIYDVSPEVVASQIEAVSDDIGVDAAKTGMLSNKEIIHAVSGVLKKYDFPLVIDPVMVAKSGAKLLKDDAIEALKNELLPRAKIVTPNRMEAEILSNEKIQTIDDAIKAAKKIKKEYVPEAVVVKGGHISEDSKYAVDVLYVEDHAILLEGERVNGCTHGTGCSFSASIAANLAWGYDIIEAVKNAKEFITHSIKTGINYGSGHCPVNSSSWIYIPAEKFNIIKNLEQAVSLLVDNSEEFVKYYPEVGINLAMSLPSWYVKDENDVAGIPGRIIRIGKKLEACYKPEFGASKHVAKSIIAIQKHDPSIRAAMNLVYDESFLENAERLGYIISGFDRKFEPEDVKKTEGATTPWGIDFAIKKIGKVPDIIYDVGEPGKEALVFIFGQSAKDVVEKALRIIRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZX3</accession>
    <name>H9ZZX3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0282 protein FFONT_0290</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0282 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0290"/>
    <dbReference type="EnsemblBacteria" id="AFH42280">
        <property type="protein sequence ID" value="AFH42280"/>
        <property type="gene ID" value="FFONT_0290"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0290"/>
    <dbReference type="eggNOG" id="arCOG00969">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079268_0_0_2"/>
    <dbReference type="OMA" id="YHYDHHT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01406">
        <property type="entry name" value="UPF0282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014426">
        <property type="entry name" value="UPF0282_hydrls"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43546:SF4">
        <property type="entry name" value="PTHR43546:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004944">
        <property type="entry name" value="UCP004944_hydrls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="40"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="278" mass="32306" checksum="6ACD0EFF616EE423" modified="2012-06-13" version="1">MANIVEAKGFKIFIDPGAALAPYRYGLPPHEIELNELEKSIEKICKNLNDSNLIVITHFHRDHYLSNDYCIEAFKNKTIIMKHPEIDINYSQKMRAKEFIKKTKDISKLIFTNGEDFVFEGIKMKISFPLWHGSQNTPLGKVLVILIDDEEQRYLFASDTQGPGDDEAARWIINNKPTIVYISGPPYYLIGSIKGVEEVENGEKNLEKIFSINTLNTIIIDHHFAREKNYVNRLERLRINYNQKIKITDAAEFMGVERNPLESNRDELYNRKLHFSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZY1</accession>
    <name>H9ZZY1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0298"/>
    <dbReference type="EnsemblBacteria" id="AFH42288">
        <property type="protein sequence ID" value="AFH42288"/>
        <property type="gene ID" value="FFONT_0298"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0298"/>
    <dbReference type="eggNOG" id="arCOG00600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076812_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="118"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="310" mass="35096" checksum="EE59CB30EB7BEF5D" modified="2012-06-13" version="1">MGSNYFRSRIEGYRWLRSDGKPSFSTRVYRVEKELERLAKKIFVSVSQTSPVLDAIEKMYTFQEEQLLVLHGESNFSGLVTSENVIDYLGGGELYNIVMDRHGGEIHSALNEQVKTIMIKESPFVYINEKLPDVISSMIKNKTRALPVLYKDNTVYGIITQRDIVMLLAEKRTGVKAGEICSPIISVNSLDPLIVGMKMLVQTSLDSIYVKNEMDQIIGTLDSSGIVQLFGSHEAFKFVKKGYLTEVNSIPIKDVMQFNIERVYKQVDMGDVISKMFNKKLKTVLVTDENDEDIGMITFDDAFFVLALPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZY4</accession>
    <name>H9ZZY4_FERFK</name>
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        <recommendedName>
            <fullName evidence="1">Mut7-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0301"/>
    <dbReference type="EnsemblBacteria" id="AFH42291">
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        <property type="gene ID" value="FFONT_0301"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112469_1_0_2"/>
    <dbReference type="OMA" id="CGQIYWP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002782">
        <property type="entry name" value="Mut7-C_RNAse_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01927">
        <property type="entry name" value="Mut7-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mut7-C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="159" mass="18441" checksum="E0FB9FAED74FA0E1" modified="2012-06-13" version="1">MEKRFIVDCMLGNVARYLRILGYDTLYEIDISDDEIIEKAKKEDRIIITKDNLLWKKALSDGANAFLVKKSYSNTKDILCELKKNGLISLKFSPHNSRCPLCNGKLMISINQPLLKIHKNSEMRVYFVCQSCGNIYWIGKHFKNILKTLEDAEYEANRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZY6</accession>
    <name>H9ZZY6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0303"/>
    <dbReference type="EnsemblBacteria" id="AFH42293">
        <property type="protein sequence ID" value="AFH42293"/>
        <property type="gene ID" value="FFONT_0303"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0303"/>
    <dbReference type="HOGENOM" id="CLU_3245197_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="42" mass="4781" checksum="A6D95B61427E968D" modified="2012-06-13" version="1">MQQYPKASEGSIDFIAKHPKKFYNLLIAALWKSSLTLIEVCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZZ1</accession>
    <name>H9ZZZ1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyltransferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FFONT_0308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GtrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0308"/>
    <dbReference type="EnsemblBacteria" id="AFH42298">
        <property type="protein sequence ID" value="AFH42298"/>
        <property type="gene ID" value="FFONT_0308"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0308"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG02228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039727_0_0_2"/>
    <dbReference type="OMA" id="TAYIHGF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007267">
        <property type="entry name" value="GtrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04138">
        <property type="entry name" value="GtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
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        <location>
            <begin position="8"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="GtrA" evidence="8">
        <location>
            <begin position="243"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="377" mass="43012" checksum="5C5F842D6723D93B" modified="2012-06-13" version="1">MEELKEISIIIPTFNEAENIGALFERIAASLANYDYEVIIVDDNSPDNTSKVAVQEAKRLDIEKNVRVIVRNNERGLSTAVLRGMNEAKGKVLVVMDADLQHPPEKIPDLYRKIAIENYKIVIATRMGKNGYKNMPTYRRLISKIAGGLAKLLLPKLKNVSDPMSGFFALKREVYLETKDKLNPKGYKILLEIIVKSHVKQNDIGEIEYVFEKRYAGKSKLGLKEYINYILHLLSLNEYRILKFMLVGLSGTAVNEAALWIFHYIFHLPLYISGAFSIELSIINNFILNSIYTFKSSEKSITFKKFFRYHISSAIGISINYVILLFLSTILKVEPLISNLVGIIFGFVANYLLSEHYVWKIEDSGLNSQFSKRRVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A019</accession>
    <name>I0A019_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CDP-alcohol phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0336</name>
    </gene>
    <organism evidence="3 4">
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0336"/>
    <dbReference type="EnsemblBacteria" id="AFH42326">
        <property type="protein sequence ID" value="AFH42326"/>
        <property type="gene ID" value="FFONT_0336"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0336"/>
    <dbReference type="eggNOG" id="arCOG00671">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1227622_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="225" mass="26185" checksum="96D3DCF5E6C10CBF" modified="2012-06-13" version="1">MINRKDLPNLVTVINGLVGSFALLLAIRGETELSIRLIFLSLSLDVLDGLLARKLNAMSESGELLDRVFDRVYQVIAPSIIYCYMQNWNVGSMFYSASIITLSFWRIIRRTPSKEYFLGLPLFVHTFVILSSYLSGIALPYYLMLVLVIASLFPIKYFRRIRTLSPNETKGTFWQIRIIVPLFLSIIPYSKLEILFELLFYIFIIYALFGWIPLLRNKNFFLREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A048</accession>
    <name>I0A048_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="ordered locus">FFONT_0365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0365"/>
    <dbReference type="EnsemblBacteria" id="AFH42355">
        <property type="protein sequence ID" value="AFH42355"/>
        <property type="gene ID" value="FFONT_0365"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0365"/>
    <dbReference type="eggNOG" id="arCOG01337">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_2"/>
    <dbReference type="OMA" id="ITACDEV"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="12"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="318"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="384" mass="42257" checksum="67268FF26D3AE40A" modified="2012-06-13" version="1">MIKVKLFEYEAKEIYKLHGIKVPKGVVIAKSDDIEKKIEESKLKFPLVVKSQVLVAGRGKSGGVKFAKDINEAVTVSNNLFNLEIKGLKPNFLLIEEAVEHDNEYFASITIDRAERCPVILVSKSGGMEIEEVSKKSPESIIKYHVDPILGMRDFEARNIGYKLGLSGKELASFTSFLKSLYNIFEMYDGDLVESNPFTIVNGEVIALDSRIIIDDNSVYKHKELVANKEMSGEETEWEIRAKQRGFAFVELDGNIGIIGNGAGLTMATMDLIYEFGGSPANFLDIGGGANSERVKEAVSLLLEYPKAKSIFINIFGGITRCDEVARGIEGALKSVGKIKPIFVRLSGTNEEEGKRILKELGISSYNDPIEAARSTVNSVKGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A075</accession>
    <name>I0A075_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thiamine thiazole synthase</fullName>
            <ecNumber evidence="4">2.4.2.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">thi4</name>
        <name evidence="5" type="ordered locus">FFONT_0392</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>glycine + hydrogen sulfide + NAD(+) = ADP-5-ethyl-4-methylthiazole-2-carboxylate + H(+) + 3 H2O + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:55704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:139151"/>
            <dbReference type="EC" id="2.4.2.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
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    <comment type="subunit">
        <text evidence="4">Homooctamer; tetramer of dimers.</text>
    </comment>
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        <text evidence="4">Belongs to the THI4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:thiazole biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
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        <property type="entry name" value="TIGR00292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0784">Thiamine biosynthesis</keyword>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="56"/>
            <end position="57"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="129"/>
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        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
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            <end position="159"/>
        </location>
        <ligand>
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        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Fe cation</name>
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        </ligand>
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            <position position="174"/>
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        <ligand>
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        </ligand>
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            <position position="224"/>
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        <ligand>
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        </ligand>
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        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>glycine</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="259" mass="27986" checksum="2EF5FF1F0E08AD0A" modified="2014-02-19" version="1">MSENLEFKITKLILEHSMKDLIEFADSDVIIVGAGPSGMTAAKYLADKKLKVLVLERKLSFGGGIGGGGNLMHKIVIKSDALKIIKDFEIEYKKTEFEDLYTLDASELISKLATGAINSGAKILFGYSVEDLIVREKPLRVSGVVVKWSAIDLAQLHVDPIFFTGKAILDATGHDAELIKILAKKNPSFAINVKNESSAHAELGEKQVVEFSGKVCDGLYAAGMSVATLHGLYRMGPIFSGMLISGKKVAELISKELGK</sequence>
</entry>
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    <accession>I0A077</accession>
    <name>I0A077_FERFK</name>
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        <submittedName>
            <fullName evidence="1">3-isopropylmalate dehydratase</fullName>
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    </protein>
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        <name evidence="1" type="ordered locus">FFONT_0394</name>
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    <organism evidence="1 2">
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="PAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="AFH42384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="262" mass="29489" checksum="CF885F89544691A9" modified="2012-06-13" version="1">MVKSLNIIREEEIGGILIQEYEEFKLESPSFLIVGFPDAGLVGGISLNHLIRELNPKEIAGIDIPRLNPPIAIIRKGEYHPPIRIFKKDNILFLVSEIPIPANTVQPLSYAILEYCMRRRVDYVIGLTGIGSTERLNKEKPDVFIAYEGDQAKRMILINEGKVFDEGMLMGPFAIFLKEAKRFNLQSLIILAESFPDLPDPEAASVAVEYLSKILSIKISIDKLLEEAEYIRLRTKEIMKQTAKVMGQMGRSAEAQPGILYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A084</accession>
    <name>I0A084_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    <organism evidence="1 2">
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="127" mass="14918" checksum="BD58578224EFAFD6" modified="2012-06-13" version="1">MDILACPICKKFPLELIVIESVEKERKLSQKAPLCELYCAYRGDFIKNLTTPPPCEECFKREIETGVLYCPGCGRWYPIINGIPHMLPDYIRKEEKNKDIEFLKKYKDKLPEKIWKKGMPYNLGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A099</accession>
    <name>I0A099_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0416</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42406">
        <property type="protein sequence ID" value="AFH42406"/>
        <property type="gene ID" value="FFONT_0416"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0416"/>
    <dbReference type="eggNOG" id="arCOG03199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_4_1_2"/>
    <dbReference type="OMA" id="DDILGWK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="338" mass="37666" checksum="6FBA3344DE09F403" modified="2012-06-13" version="1">MYVDLFISAIVGIFFTYFFTFIVERFERRIGLLGEDVHKKPGRFLPKSGGLGFLFGWSFSILIYMFMNAGNKMIFNDLITILLIIWFVGIVGLYDDMKRLGGITKVLLTALPGIAIYFASLYRPFVFIPFLGNARLSIVYPILLPIIYAVASNAINMTDTFTGVAPGVVLILTIFTFLSFLFFPLLPKSDPLYQIAIILAVLTISSLIGYLPHNFYPGKSFNGDCGSLSWGAILATIAILSKTEFFLVMAAIPIVTNGFTILSSIKGIIEHHELKTRPTIPDRDNNIIKANPDENAPITLAHLLTLKNPLSEKELVISLYLLVSISSIFTMIFYAILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
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    <name>I0A0A0_FERFK</name>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
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    <name>I0A0B7_FERFK</name>
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        <submittedName>
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    </protein>
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    </gene>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000007391">
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    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42424.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="93" mass="10494" checksum="B6AAAFF964A502E4" modified="2012-06-13" version="1">MKKLNENLFNIKADIQISLTNENLCKSIINSLVPDDLTSSPELQVKTYNLKTSILIQIVYKGINILTVRNTIEDYINSIETVINSIKGAKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0F6</accession>
    <name>I0A0F6_FERFK</name>
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        <submittedName>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kublanov I.V."/>
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                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S8 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
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        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
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        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
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        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase_S8" evidence="5">
        <location>
            <begin position="182"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="1257" mass="137666" checksum="3DFAE8680602A151" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0F8</accession>
    <name>I0A0F8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0475"/>
    <dbReference type="EnsemblBacteria" id="AFH42465">
        <property type="protein sequence ID" value="AFH42465"/>
        <property type="gene ID" value="FFONT_0475"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0475"/>
    <dbReference type="eggNOG" id="arCOG03765">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1393530_0_0_2"/>
    <dbReference type="OMA" id="YGMPYSV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="194" mass="21830" checksum="DBA3424FEF74F8CA" modified="2012-06-13" version="1">MSERGKKRFLAISEDIITEAMNISEKVGIPFTTLIERALSDVFKVMKYKPQLIDALSYADAVDDIRKLGGIVIPMTFFKKNIEKLSDKELEDLANELYKMSLWYGELAKVKRGISVDELKRAISLWIPSSNIEVIENGSEMKIIVSLLDANDKVLSVSKRIIEGLLEGFDLKVKEISLGNSLIIAKVHGKIEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0I0</accession>
    <name>I0A0I0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecY</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protein transport protein SEC61 subunit alpha homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secY</name>
        <name evidence="4" type="ordered locus">FFONT_0497</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0497"/>
    <dbReference type="EnsemblBacteria" id="AFH42487">
        <property type="protein sequence ID" value="AFH42487"/>
        <property type="gene ID" value="FFONT_0497"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0497"/>
    <dbReference type="eggNOG" id="arCOG04169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031763_3_0_2"/>
    <dbReference type="OMA" id="KWGIGSG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="426"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Plug_translocon" evidence="3">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="465" mass="51454" checksum="089B17629CA453AA" modified="2012-06-13" version="1">MSNYLGFLDALAKFSYILPTVKKPSRKLSLYRRLGITGLVLVLYLIMADTPLYGVPYTSQSQISLFQILFAANTGTLMELGIGPIVTGGLILQILVGAKLIDLDLSDVDDRRKFTEAQKTLSFLFGIFEALAYVLASRYWPYVGNPITGSQASWAIRIGVLLQLTFATYLVMVFDEMLQKGWGIGSAISLFILAGVAKTMFWDLFGYTPQYAQQIGLIPYIVQATEANNLTSIVVRQGLPDVVGLLATIIAIIGLVYLQGMRVEIPVTSQKYGGIRSKIPLQFLYVTNIPILLVGIIVSDFQLFANAFASISGTQNLGYRILYELSYYLSPPRGLYSATADLTKLFIFIISWVVLSVLFGYMWVEIAGLGPKEQADRLIKGELDIPGVRRNPKFFEKMLAKYIYPLTVLSSLIVAFIAIVADIFGAYGSGTGILLAVGIINQYYMMIARERALEAYPLLKRIMGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0J1</accession>
    <name>I0A0J1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">30S ribosomal protein S4e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rps4e</name>
        <name evidence="9" type="ordered locus">FFONT_0508</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0508"/>
    <dbReference type="EnsemblBacteria" id="AFH42498">
        <property type="protein sequence ID" value="AFH42498"/>
        <property type="gene ID" value="FFONT_0508"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0508"/>
    <dbReference type="eggNOG" id="arCOG04093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060400_0_0_2"/>
    <dbReference type="OMA" id="FPVGLMD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_S4e_central_region"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_S4e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="PTHR11581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="S4" evidence="8">
        <location>
            <begin position="43"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="248" mass="27961" checksum="A0F96E8CD0993E26" modified="2012-06-13" version="1">MARMGGSKHLRSYSAPDFWPISTKERFWAIKPSPGPHSLSSSIPLGIVLRDYLKYARTKREVIRALSMGLVKVDGKVRKDYKYPVGAMDVIEIVPSSLFFRAVPNMDKFISFVEIPKEEASIKPLRIENKTTVNHGHIQLNLFDGSNILIKVSDPKNPTEVPYRTLSTVIVKIPEREIIDYIPLEEGVYAIIFGGKNTGIMGKVKEIRKGMKRYRSLVVIETDDGSIAQTSLDYVLAIGREKPIIKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0L2</accession>
    <name>I0A0L2_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0529"/>
    <dbReference type="EnsemblBacteria" id="AFH42519">
        <property type="protein sequence ID" value="AFH42519"/>
        <property type="gene ID" value="FFONT_0529"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AKR"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
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    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
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        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldo_ket_red" evidence="1">
        <location>
            <begin position="15"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="272" mass="30796" checksum="8D94BFBC54B2929C" modified="2012-06-13" version="1">MEKKCFKNIGCVSALGIGTWGIGGGFWTPDYSQDLENEKILKYAIRNGITLIDTAEMYGGGHSEEIVGNAIKGERRDELFIVTKVWNANASYDRVLKSAEMSSKRLGTYIDLYLLHWPSDTVNICETIRAFEELVERGIIRYYGVSNFSVERLEGAMNCQKKFEIVAVENQLSLKNKEDLYNVVEYAKRKGMLYLAYTPIDKGTIANSGILKEIGQKYNRSPVQVALNWLISIQPVVPIPKASNLKHLKENLGAVGWRISEEDWKLLEKAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0R2</accession>
    <name>I0A0R2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0579"/>
    <dbReference type="EnsemblBacteria" id="AFH42569">
        <property type="protein sequence ID" value="AFH42569"/>
        <property type="gene ID" value="FFONT_0579"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0579"/>
    <dbReference type="eggNOG" id="arCOG07486">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_089225_3_0_2"/>
    <dbReference type="OMA" id="GVIFWAW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017195">
        <property type="entry name" value="ABC_thiamin-permease_prd"/>
    </dbReference>
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        <property type="entry name" value="ABC_cobalt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="184" mass="19378" checksum="A09E45A8E456B35E" modified="2012-06-13" version="1">MNSAEKKEKKKTSYTGIDLAILALVGVVTGIIFAGSWSIYYAVEAVGGPVGARLASYGLWFIGAPLAATLIRKPLSALFGEVIGAFVETLIAPAGGITNIIYGLLQGLASEFVYFLFRYKRWDIISGVLSAIAAGPVAVALDALLFGTIGSSIEMSLWVIASMVSGAVYGFIATYAAKSIRRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0R7</accession>
    <name>I0A0R7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TrkA-N domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0584"/>
    <dbReference type="EnsemblBacteria" id="AFH42574">
        <property type="protein sequence ID" value="AFH42574"/>
        <property type="gene ID" value="FFONT_0584"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0584"/>
    <dbReference type="eggNOG" id="arCOG01957">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1187742_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RCK N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="233" mass="26019" checksum="787226750A9AA35D" modified="2012-06-13" version="1">MRHVIVGSTHFTTFALKGIREADPSGIIIVIERSIEVATIMAKQVNGKAVAGDLRDKKVLESAEINLADTFFSLTDSDALNIKLCSFAKKDFSVPIVVGLINNPMNYENMREAGADFIIDPTLFLENYVKSIIAIDRPVKYELPNFLGLDILALRPSKLLEGKEALVSFVKNINTKNEVKAIRVLSSKENKPKNIDEIEQGDYLIFAIEKEKSEGFQEKIKDFVKKTLGLKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0S3</accession>
    <name>I0A0S3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0590"/>
    <dbReference type="EnsemblBacteria" id="AFH42580">
        <property type="protein sequence ID" value="AFH42580"/>
        <property type="gene ID" value="FFONT_0590"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0590"/>
    <dbReference type="eggNOG" id="arCOG00663">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="TMCVREY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="6"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="235" mass="26761" checksum="CC215FC9F60A81AE" modified="2012-06-13" version="1">MKVETAAILAGGYGKRLRPLTDSIPKPMIEVGGRPILEWQMLWLRSLGIKKFVLLVGYLGEIIKSYFGNGEKLKVEIKYSFENEPLGTGGAIKNAYNVMKDEKYFFVVNGDIITNLNPYEMVSDLEDEIGVIALAPLQSQYGVVDVDTNGHIRGFREKPKIEGIWINAGVYLLKSEIFEMLPKKGDIEKETFPKVAEQNKLKGKKYFDIYWKSIDSHKDLEEVDKAIREKKVFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0S4</accession>
    <name>I0A0S4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42581">
        <property type="protein sequence ID" value="AFH42581"/>
        <property type="gene ID" value="FFONT_0591"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0591"/>
    <dbReference type="HOGENOM" id="CLU_2079320_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="117" mass="13319" checksum="FED2A4B2FCCC93BB" modified="2012-06-13" version="1">MERMILIARAQDVSEETALGLKKCIDDYSIKSFPLINPLIYDTRAFNWSEGKYTELVIKLLREQLSFEEVPAVIIVGDLIDIKGYACNKALKVCLLQKDFVKTDGVIKEILSALEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0T1</accession>
    <name>I0A0T1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable transcription termination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nusA</name>
        <name evidence="7" type="ordered locus">FFONT_0598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Participates in transcription termination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0598"/>
    <dbReference type="EnsemblBacteria" id="AFH42588">
        <property type="protein sequence ID" value="AFH42588"/>
        <property type="gene ID" value="FFONT_0598"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0598"/>
    <dbReference type="eggNOG" id="arCOG01760">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131906_0_0_2"/>
    <dbReference type="OMA" id="TDQIKYI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_A">
        <property type="entry name" value="NusA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010212">
        <property type="entry name" value="NusA_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01952">
        <property type="entry name" value="nusA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="KH" evidence="6">
        <location>
            <begin position="33"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="143" mass="15584" checksum="4D70119BD7577F37" modified="2012-06-13" version="1">MPEIKLTPEELRHIALFQDVTGTTVKDCIIDNENNMIIFVVKKGEAGAAIGRGGSNIKKLRKVLGKEIEIVEDGTTLEELAKNAVAPARVKAVKVVETPSKKTVYITVEPSDKGVAIGKNGKNVTRAKLLLKRYYDVSNVIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0U1</accession>
    <name>I0A0U1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42598">
        <property type="protein sequence ID" value="AFH42598"/>
        <property type="gene ID" value="FFONT_0608"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0608"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="52" mass="6153" checksum="2993DD60C42E7871" modified="2012-06-13" version="1">MKVSFNEAGMEWTTFNTGGPEKICEEPKRENNVIQLAFKYKIYPTREDVKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
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        <name evidence="4" type="ordered locus">FFONT_0627</name>
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    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
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    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PurM-like_C_sf"/>
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        <property type="entry name" value="PurM-like_N"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
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    </dbReference>
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        <property type="entry name" value="SSF55326"/>
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    </dbReference>
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        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="48"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="151"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="346" mass="37577" checksum="A428282B5D88B753" modified="2012-06-13" version="1">MVIKLPHEVMMKYVLNRVGREDPQVIMGPKIGEDASIIDLGDGRVLVSHVDPIVGAIESIGWLSVNIVSNDIAVRGVEPRWLLSDILLPESSSIDLLDRITSQIDEAAKEVGVMIVGGHTVFAPKLTRPIVSMTAIGIGEREKIVTTSGAREGDEIVMTKTAGIEGTAILVTDFKDVLLKKGIKEEVLERGREFLKMVSVVKEALALSRRGLANSMHDATNGGVLEGVAEMAYASRKTIELFEDRIPVAEETASMSKALGIDPLKLISSGVLIASVPSGRGREAVELLRSIGIKGSVVGRVKEFSGDYLLLHRKNGGIERIGDIYIEDELDNLWESYRKEVSKSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0W6</accession>
    <name>I0A0W6_FERFK</name>
    <protein>
        <submittedName>
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    </protein>
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        <name evidence="1" type="ordered locus">FFONT_0633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42623">
        <property type="protein sequence ID" value="AFH42623"/>
        <property type="gene ID" value="FFONT_0633"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="40" mass="4130" checksum="39BD06CACF805B53" modified="2012-06-13" version="1">MGVKGTSYPHNSLLHVIDKVASAISPGLAEILAIAAKPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Y2</accession>
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        <submittedName>
            <fullName evidence="2">UDP-glucose 4-epimerase</fullName>
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        <name evidence="2" type="ordered locus">FFONT_0649</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="9"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="220" mass="24002" checksum="7B9857E97784BC39" modified="2012-06-13" version="1">MKQERAMRVLVTGGAGFIGSHLVRSLVFSGFQVRVLDNLSRGSLDNIRGVLDSIEFVEGDVRDYGTVGDAVRGVDAVVHLAALTDVAESTVEPDLYFDVNVRGTYNVAKASRSVSVFVFASSSAVYGEPVKLPIPEDHPLQPKSPYAATKVAGEALVLSFSELYGYRPVVLRLFNVYGPRQSKSYTGVITEFIKRVSRGEPPVIYGWEADPGLCPRSRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Y7</accession>
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        <submittedName>
            <fullName evidence="6">Phosphate ABC transporter, permease protein</fullName>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH42644">
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        <property type="gene ID" value="FFONT_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0654"/>
    <dbReference type="eggNOG" id="arCOG00168">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OMA" id="GIARWKA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
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            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
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            <begin position="12"/>
            <end position="32"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="EMBL" id="AFH42684.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="3">
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</entry>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermoprotei</taxon>
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    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025105">
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        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
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    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
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            <end position="29"/>
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            <end position="124"/>
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            <end position="212"/>
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            <end position="440"/>
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            <end position="409"/>
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        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF13194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH42706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="441" mass="48263" checksum="A7C409D004C2EB8A" modified="2012-06-13" version="1">MLSFSINSSDVDMLATLIISFLEGGLLGLERYKVGMEKQDKIESEELPGVRTYGLMSILGTILALLNSDKISVSPFANEVLTVSGAIFVTILMVSYIYFRLYRLKIAGLTSYFVFFLTFIIGFLTGYGYYILSMSLTFLIAGILAFKRAITASLEKLSYDELTAGLELGMIIFILGPFVYATNYEIYGLNLQGVYIFFTLILAISYISYMAYKLKGEKSLLAVSLLGGLINSEATLMNILKIGVKGKKLAKLSSINNSGMVIRTALTVLIGAYPFLISDGYEIFARYIISGVLLSIMILYLTYTLSGREKKAEENGEKVLYLASPLEVKIATRGVILYILIFVLVKVSNYYLGSYALFITSFIGGFASSIATVLSLLSLGSTVSIKIISSASLLSMGAAMLNKIIYAKITTDDKDALKEVLVSSIPSGIALIILSLIFIYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A155</accession>
    <name>I0A155_FERFK</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0724"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="39" mass="4922" checksum="0F18B98C5F6B003A" modified="2012-06-13" version="1">MFPYQMNEETFYKQLFYLQNIKINYFSFGKKFLTRTVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2020-12-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A184</accession>
    <name>I0A184_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Probable deoxyhypusine synthase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="7" type="primary">dys</name>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <text evidence="3 7">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
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    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
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        </reaction>
    </comment>
    <comment type="cofactor">
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            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 7">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="7"/>
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        <property type="protein sequence ID" value="AFH42741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0753"/>
    <dbReference type="EnsemblBacteria" id="AFH42741">
        <property type="protein sequence ID" value="AFH42741"/>
        <property type="gene ID" value="FFONT_0753"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0753"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="FWSYFCQ"/>
    <dbReference type="UniPathway" id="UPA00354"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008612">
        <property type="term" value="P:peptidyl-lysine modification to peptidyl-hypusine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00153">
        <property type="entry name" value="DHS"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0386">Hypusine biosynthesis</keyword>
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    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="314" mass="35226" checksum="5A5D703462429764" modified="2012-06-13" version="1">MKDGREELLKEKIMDEPPTDEQIKSFKTLISYYSQIHGFMAGHLSKAAEILSEGRKESELRFLSFTGNLVSTGLRGLFAKLIRDGHFNVVVTTAGTLDHDIAKALGPGYFKGGFEYDDSMLYEYNIHRLGNVFVPFESYGEVVEKAVKEFMEEKKGKTLAVYEALWSIGEKIEDKNSILRAAYERKVPIIVPGMYDGSFGTNALIYGRIYNVKLDLSLDEKLLEDMTFESQDKKSLALIIGGGISKHHVIWWNQFKNGLDYAIYLTTAVEYDGSLSGAQTREAISWGKLKSKSKHIVVYGDATITLPILASALY</sequence>
</entry>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0770"/>
    <dbReference type="EnsemblBacteria" id="AFH42758">
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        <property type="gene ID" value="FFONT_0770"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="AFH42758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="111" mass="12481" checksum="CD0F0FCF1B024739" modified="2012-06-13" version="1">MLRSEGCKTKAESNNVLLFKCIHEDVEYSFALEIDSISGYVRISLLTDYAYEGDYKNISAKNFELYGIKVAIDPEGYLAFIAEIPLICLTKGGIDIILNLINLLEKIIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1A3</accession>
    <name>I0A1A3_FERFK</name>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0772"/>
    <dbReference type="EnsemblBacteria" id="AFH42760">
        <property type="protein sequence ID" value="AFH42760"/>
        <property type="gene ID" value="FFONT_0772"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG04224">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157709_0_0_2"/>
    <dbReference type="OMA" id="IPELEVW"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="120" mass="13514" checksum="D96DD2D3F6649847" modified="2012-06-13" version="1">MSEEENKEASEQKVEKKDIKSLVAIIPPAGALKPTQKKISEKRIRVRYSSTKPEHITINPKLASELGIKDKAYIVIAGKKRFLFNVILDENVPENEVYANNEFMKENGVSDNSIATIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1D6</accession>
    <name>I0A1D6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0805"/>
    <dbReference type="EnsemblBacteria" id="AFH42793">
        <property type="protein sequence ID" value="AFH42793"/>
        <property type="gene ID" value="FFONT_0805"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0805"/>
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        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OMA" id="NIAFHAH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
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    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="133" mass="14476" checksum="4C65ED9E0B16BA02" modified="2012-06-13" version="1">MQVIPLKIPEGSKLPDFVISFIQVNGLKGGYLVGIGGLEEVEIGVLNRKTNQYEVSKFTRNGDSTIELLSITGNYFVKSDGNIAFHAHATFATGHEKVAGGHLISAKVSPYVELFLVETGIQVKTAFKHRDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1E0</accession>
    <name>I0A1E0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-ribofuranosylaminobenzene 5'-phosphate synthase</fullName>
            <shortName evidence="1">Beta-RFA-P synthase</shortName>
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        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0809</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
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            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-hydroxybenzoate + 5-phospho-alpha-D-ribose 1-diphosphate + H(+) = 4-(beta-D-ribofuranosyl)phenol 5'-phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:48556"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:82767"/>
            <dbReference type="EC" id="2.4.2.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-RFA-P synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.54" evidence="1"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0809"/>
    <dbReference type="EnsemblBacteria" id="AFH42797">
        <property type="protein sequence ID" value="AFH42797"/>
        <property type="gene ID" value="FFONT_0809"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0809"/>
    <dbReference type="eggNOG" id="arCOG01026">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061764_0_0_2"/>
    <dbReference type="OMA" id="RLNGAWY"/>
    <dbReference type="UniPathway" id="UPA00065"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004422">
        <property type="entry name" value="RFAP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF6">
        <property type="entry name" value="PTHR20861:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004884">
        <property type="entry name" value="Sugar_kin_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00144">
        <property type="entry name" value="beta_RFAP_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="317" mass="35875" checksum="57D671D2849F2511" modified="2012-06-13" version="1">MIYVEAGSRLHLGFYNIKEGNWFYGSLGVYIEEPKTIVKIEEKKSDEYKKEEAKIFRYHLNICGEGNVSYSIVTSPPSQKGLGSTTQLSLSIAKGLSVICSKKINLKKIAVLAGRGTISGIGIYGFIYGGFLVDSGRFSKENKLEPPSKVKDLPQLITRISFPYGWKVVIIVPRKKIGLKEEDEKFMLSPNEEKELGRKLRLSLWEKTIRGLISKNIGLFGKGIEDIQKHMGEYFSKYQGGEFSSEETEKAVEVLRHSGTVGIGQSSWGPAAYGFYEVEKEEEIRKKIEKEIYKKDIDADVYFSGIRNHGYKIREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1H9</accession>
    <name>I0A1H9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0848"/>
    <dbReference type="EnsemblBacteria" id="AFH42836">
        <property type="protein sequence ID" value="AFH42836"/>
        <property type="gene ID" value="FFONT_0848"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0848"/>
    <dbReference type="HOGENOM" id="CLU_1976435_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="126" mass="14466" checksum="BD8BA08D30E64913" modified="2012-06-13" version="1">MLLKDEKYESALKMSLNEKEITERLCVSLTSYLSCCIINEEYADVQTLIKIVRNLGLENILEVKSFYSSLGSSEHTVIVVRFKVQVCEKKCENTCGSRESECFGKCFFECIEEYKKMAKEKLCGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1M8</accession>
    <name>I0A1M8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tryptophanyl-tRNA synthetase</fullName>
            <shortName evidence="7">TrpRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trpS</name>
        <name evidence="9" type="ordered locus">FFONT_0897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the attachment of tryptophan to tRNA(Trp).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + H(+) + L-tryptophanyl-tRNA(Trp)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="7"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0897"/>
    <dbReference type="EnsemblBacteria" id="AFH42885">
        <property type="protein sequence ID" value="AFH42885"/>
        <property type="gene ID" value="FFONT_0897"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0897"/>
    <dbReference type="eggNOG" id="arCOG01887">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032621_3_0_2"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00140_A">
        <property type="entry name" value="Trp_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020653">
        <property type="entry name" value="Tryptophan-tRNA-ligase_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="256"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="373" mass="42992" checksum="D8B3B670A803B85D" modified="2012-06-13" version="1">MEENKKEIILDPWGYSSIEDYDKLFTLFGIRPFKEVIHYFENPSILMKRGIVFGHRDFDVVLRAFKEGKKVTLLTGFMPSGKLHFGHKALFDQIIYYQKQGFHINLALADIEAYSVRKVERKETIRLAIEEYVANAIALGLEKKNLRIYFQSATKPAYYRLIQMFSQKVTMAEMTAIYGDLTPGKIVSVFTQAADILHPMLEEFGGYDYVFVPVGADQDPHIRFTRDISDRFSSELGFRRPASTYHRFMTGLDGGKMSSSRPESAIFLSDPPEIVVKKLNNALTGGRATIEEQKRLGGEPLKCAIYEMYLYHLMPNDKDLLDIFMRCRRGELLCGEDKKLAIEKTLKFLDDHRKKLEQAKDVAESYIEEIPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1N7</accession>
    <name>I0A1N7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Amidinotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0906"/>
    <dbReference type="EnsemblBacteria" id="AFH42894">
        <property type="protein sequence ID" value="AFH42894"/>
        <property type="gene ID" value="FFONT_0906"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0906"/>
    <dbReference type="eggNOG" id="arCOG03108">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049514_0_0_2"/>
    <dbReference type="OMA" id="MHLDTYF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="432" mass="50218" checksum="3B96B6423D440A7D" modified="2012-06-13" version="1">MGIKAEWDPLKKVVMHRPGIEMFFSLIEPYASLYDRAFSQNEALREHERLEHILMHEFRVDVIRLKDFILQEAERSSKVKEELVKMAEERVEFRGDEEDVKMAKDEFSRYKDIYDSEFFFNLILLSPKVTLERGRGERAIYYNVTVREPLGNLYFMRDQQAVTDKGIILSRMSKPQRRRETQVTKFLWKLMGEEIVHEIKEPGTFEGGDFIPMKDFALIGTGDRTNQEGIEQILKHGVSFDEVAVVHQPAHPLIPGDQTDPMINMHLDTYFNVPSSNVVIGCDTLLKRAKIDVYIKESEGNYRKEEERNLNLYDYIKEKGFEIINITTLEQMSYASNFLTIKDGTILAIETERIVKRTLANLEASARLNPERYGKLLEQAKKDYEHLKNEGQFFPHKKEMYKNGIDVYTVDLTNLTGGYGGAHCMTCSLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="AFH42898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_0910"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="entry name" value="OPT"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
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            <begin position="21"/>
            <end position="38"/>
        </location>
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            <begin position="44"/>
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    </feature>
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            <begin position="606"/>
            <end position="624"/>
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    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="633" mass="66137" checksum="E5185049490E86CD" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1R4</accession>
    <name>I0A1R4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0933</name>
    </gene>
    <organism evidence="6 7">
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        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0933"/>
    <dbReference type="EnsemblBacteria" id="AFH42921">
        <property type="protein sequence ID" value="AFH42921"/>
        <property type="gene ID" value="FFONT_0933"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0933"/>
    <dbReference type="eggNOG" id="arCOG01608">
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        <property type="term" value="F:2-oxobutyrate synthase activity"/>
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    </dbReference>
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        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
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        <property type="entry name" value="THDP-binding"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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            <end position="227"/>
        </location>
    </feature>
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            <end position="382"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="412" mass="45378" checksum="9B5388E5D36D8EF2" modified="2012-06-13" version="1">MSSEIKNIPPVAIEKPKFKVWNGARAIAEAVKVADVDVISAYPIRPYTGIMNALASMIANGEFIADVVIADSEHSQFEIVKHASAVGARTFVGSSGVGLAYAAEAIIVTALSQLPVVGAIGTRALDDPGNFGMEWSDVLMFRDYGWLISWAKTVQEAHDMTLVAYRVAEDKRVLLPHFVVLDGAALTHVATPIVPVTKEQATDFLPPYKPPYRIDPIDGPVTKAQHIAPSLIGPEQRKLVDVATKRAKEVIVEAWKDFATYTGREYPPFIEAIGMEDADFALIGMGAYMKDIEIVAKRMREKGVKIGTIRLRYVRPFPAEDLLRVIDGVKAAGVIEFGYSFGSPFGTGSLYHEIATSLYETNTRPELLDFLFLGGREPKVEHFMKAAEMIIESVHKKPQKKAYWLTLRGEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1R6</accession>
    <name>I0A1R6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multiple substrate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0935</name>
    </gene>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0935"/>
    <dbReference type="EnsemblBacteria" id="AFH42923">
        <property type="protein sequence ID" value="AFH42923"/>
        <property type="gene ID" value="FFONT_0935"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0935"/>
    <dbReference type="eggNOG" id="arCOG00492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_2"/>
    <dbReference type="OMA" id="MRLNFTY"/>
    <dbReference type="Proteomes" id="UP000007391">
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    </evidence>
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    </evidence>
    <sequence length="418" mass="47429" checksum="36AD7AF7CB279954" modified="2012-06-13" version="1">MKERSIEKTEALSLKHEKFFSKKALEMKASETRELLKLVENSNVISLAGGMPAPETFPVDIIGEITQEVIKNHAAQALQYGTTNGFTPLRNAIVEWMKKKYSIQISKDNLIITTGSQQALDLIGRVFINPGDVVIAEAPTYLSALQAFEYYKPEFVQIPLDDEGIRIDLLEEKLKELKSQGKSVKFVYTISIFQNPAGVTMSEKRRKEILELASQYDFIIIEDNPYGELRYSGSPIRPIKSWDDDGRVLYLGTLSKVLAPGFRIGWIAGDPRFINKLEIAKQSVDLCTSTFNQVIAWKYIEGGYLDKQIPKIVEFYKPRRDAMLKALEDFMPEGVKWTKPEGGMFIWVTAPEGIDTKLMFEKAVAKGVAYVPGEAFYAHREVKNAMRLNFTYVSEEKIREGISRLAETIKEEIKKSKI</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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        <source>
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    <sequence length="296" mass="33331" checksum="3A5DD817204416A7" modified="2012-06-13" version="1">MANEILEKAREFCEQEYEDSMLYAYIASKEKDENRRKILEAIAKDEEGHYKFWKKLYGKDCKTESINSKMLFFLFLRKLFGITFTLKYLENKEKKAIESYKKMLSELKGEDAQVLMKIIQDEEIHEKTEIQSLDEKVVRYMSFIILGLADAIVEINGVHAGFLGVTESTIVTGIAGMVVGVSAAISMASAAYLQAKHEAGKSPRTSALMTGLAYISAVSVLALPYFLIRKMLTAFLVSISIAILMIASFTYYGSTLQEKDFKREFIESTLLMLGTAFVTYFFGDLLGTAFGIRGIL</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00020756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="205" mass="23805" checksum="D6BAC586FF1409C5" modified="2012-06-13" version="1">MEEGNIESLLEYVINKVINEFKDTVEELRKDAHELLDDAYKNTKNSLVKELSDLYENYVESVNNLRSLRQYEIKIKTQEKKAEIVDLALKEVEKKIFYELDKEEKKIIYEAILSKLKESIKLTNGEIHIEKEDKDLVSKIIKKKLEDSKEKIKIIDDLPSGTGGIKFVSQDGSTVYDFTLKKIFELSKFELASIVYNVLFGGEEK</sequence>
</entry>
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    <accession>I0A1V9</accession>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        </source>
    </reference>
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    <proteinExistence type="predicted"/>
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        <source>
            <dbReference type="EMBL" id="AFH42966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
    <sequence length="63" mass="7227" checksum="220DD126786BB672" modified="2012-06-13" version="1">MMKALIMSSKVEDRLELINTYVINGIKRYVFRDMKTKIYLNVAADTEEEAKSKAKDILSKVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1W4</accession>
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        <submittedName>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0983"/>
    <dbReference type="EnsemblBacteria" id="AFH42971">
        <property type="protein sequence ID" value="AFH42971"/>
        <property type="gene ID" value="FFONT_0983"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0983"/>
    <dbReference type="eggNOG" id="arCOG01349">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_5_0_2"/>
    <dbReference type="OMA" id="RWGDERY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="276" mass="30895" checksum="3FAAA2E552B86C1B" modified="2012-06-13" version="1">MSNFDLNYEELMNISRKIAEEASKELAKISQDERSFEHLDKGKETIKADKLSEDLIIEMLKNEGIRGTIVTEESEVIKEGNENIIAIIDPLDGSKNYARGIKWCSVSIAFAEQRGNGINDIVAGTVKPVFFNESFSFYKRGGVFVNNEKYYIKKQPGIDKEKYYAVYFDNDNAIETVKNIREKLINRGYIATFRSLGSAALELALVSIGKIDGFIDARSKLRIVDAAAGIGMIIENGGVVRGLDGEDFLDIDLKKMYRFKSLIALSSIEEARTVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1W6</accession>
    <name>I0A1W6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0985"/>
    <dbReference type="EnsemblBacteria" id="AFH42973">
        <property type="protein sequence ID" value="AFH42973"/>
        <property type="gene ID" value="FFONT_0985"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0985"/>
    <dbReference type="eggNOG" id="arCOG00062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_8_2"/>
    <dbReference type="OMA" id="LVLPEYW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="270" mass="30685" checksum="A48A66BF12DA209B" modified="2012-06-13" version="1">MNSEFELIVVQHKREDDLEKNLMRLIKNLRAIKIEKNSIIVLPEVWLTKEILEYSTLKSFLTQLEILSNELGVWMVPGAFYVRENGKALSKSYIISPKGESKAISEKIFPSYPMKERNEISPGSFLKVEDLGFTKIGVIICVDAMYPELSRLLAIRGAELILNPSSIPENRVQLWESISVTRASENTVYWASVILTGTSYPDGRKVLGGSIVVDPGGRIILKSGASEEIVRVTLDKNVLENQRKRWVYLEDVKKSALWEVYKRLDSFIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Y8</accession>
    <name>I0A1Y8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1007"/>
    <dbReference type="EnsemblBacteria" id="AFH42995">
        <property type="protein sequence ID" value="AFH42995"/>
        <property type="gene ID" value="FFONT_1007"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1007"/>
    <dbReference type="eggNOG" id="arCOG04066">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1217517_0_0_2"/>
    <dbReference type="OMA" id="MATPWHL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009185">
        <property type="entry name" value="Nucleotidl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005928">
        <property type="entry name" value="Nucleotidltrnsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="30"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="241" mass="27688" checksum="5DE2F8511D3FBE64" modified="2012-06-13" version="1">MVREKVSKNYDEFYFEYGEKELKILNEKRKKARNIMGILESKNIRSFLHGSVARGDVHSKSDVDIVILQDIPSYVIELTLESFGILPVLKRIVQATPSNSPKAYLILDPEEEVVVSFPLTKLMKREVEFYSFGGIIDYGQLMKNVRVPGVNKKLELIKPIEEGYTKSSIIGREEEIASLLKISIDTILERERVLIRRDEKGRTGVYLNIELYPEDPIEDAVLKASEKNPALKKVLRERGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Z0</accession>
    <name>I0A1Z0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1009"/>
    <dbReference type="EnsemblBacteria" id="AFH42997">
        <property type="protein sequence ID" value="AFH42997"/>
        <property type="gene ID" value="FFONT_1009"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1009"/>
    <dbReference type="eggNOG" id="arCOG00492">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_0_6_2"/>
    <dbReference type="OMA" id="RACYVIP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="406" mass="46931" checksum="9B5C49FBCEF5D861" modified="2012-06-13" version="1">MNYNSFLNKEISDFLSLEVPGFPEPPQGRKVIMFSEGRPNFSRFPLDKALPYVQEVFKTEYQTMLQYPPIKGNPELMKELRKLMEKYVSLKGTEDDDMIIMSGSQQALYMVSRILVDPGDYIVVERPTYLEAIFAFTYNKAKMLGVNQDENGMKTDELETLLRKLKSEGKRIKFVYTVPNYQNPSGATLPMERRKHLYELASQYDFLIFEDDAYCYLSYEGKALPAIKSLDTEGRVIFTSTLSKILSPGLRIGWVFANKEIVKALLAAKEVIDLGVSGISQYLATIWLRNGIHEEFLKIAIPWYKQKRDIMLEMLDELFRNDAHWTKPKGGLFIYVQFNNKKVNTQKLLEYAKKKGVLFVSGQPFYHDFSVLNTIRLNFSMPTEDEIKEGIRLLKEAYDEYLSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Z5</accession>
    <name>I0A1Z5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase expression/formation protein HypC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1014"/>
    <dbReference type="EnsemblBacteria" id="AFH43002">
        <property type="protein sequence ID" value="AFH43002"/>
        <property type="gene ID" value="FFONT_1014"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1014"/>
    <dbReference type="eggNOG" id="arCOG04427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159381_2_2_2"/>
    <dbReference type="OMA" id="CWAVPAV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="78" mass="8619" checksum="4190C7A1E76CA02B" modified="2012-06-13" version="1">MCWATPALVKSVSSDNLKAIVDYGDGIQREVINAIPDENIQAGDTVLVHAGVIISKIDKNELEEQIEFLEGIFKDFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I0A221</accession>
    <name>I0A221_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="4">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="4">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">panB</name>
        <name evidence="8" type="ordered locus">FFONT_1040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="4 7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1040"/>
    <dbReference type="EnsemblBacteria" id="AFH43028">
        <property type="protein sequence ID" value="AFH43028"/>
        <property type="gene ID" value="FFONT_1040"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1040"/>
    <dbReference type="eggNOG" id="arCOG00584">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_2"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Alpha-ketoisovalerate binding" evidence="4 6">
        <location>
            <begin position="49"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4 5">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 6 7">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000388-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH43028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="267" mass="29419" checksum="3F80F525D92EB92A" modified="2012-06-13" version="1">MLFLDEKITMRKFIKKKELKEKIVMITAYDTPFARIADKAGVDSILVGDSLAMVVLGMENTINVSLRTMIDHVKAVARAKPRALIVGDMPFMSYEVSSKQALKNASLMIKGGAEAVKLEGGEEIIEQVKSLVRAGIPVMGHIGLTPQRFLRLGGYRMIGKKPFEEEQLLRDAEALQEAGVFSIVVEYTLSEVARKITEKLSIPTICIGSGPYCDGQVLVLHDLLGLTEKPPSFAKKYADLSKIAEEAISKYASEVRNGIFPGKEHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A240</accession>
    <name>I0A240_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ERCC4-type nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1059"/>
    <dbReference type="EnsemblBacteria" id="AFH43047">
        <property type="protein sequence ID" value="AFH43047"/>
        <property type="gene ID" value="FFONT_1059"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1059"/>
    <dbReference type="eggNOG" id="arCOG04206">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101253_0_0_2"/>
    <dbReference type="OMA" id="RDNRIWE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006259">
        <property type="term" value="P:DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
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            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43142.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="60" mass="6837" checksum="9001DC697CA62F4B" modified="2012-06-13" version="1">MIIISNKQKKIAEEKGGVFLNQYEDKNNFRAHYETTGPEIWSQMNGKIDAFVMGIGTRGM</sequence>
</entry>
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    <accession>I0A2E6</accession>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="446" mass="48506" checksum="1952A7D06FABA9D3" modified="2012-06-13" version="1">MSLKAKALFFIVVFLLLFLLFSESKISYAQSNNVIGNRVIVITVSGVIDSAVEEYVSNAIAVAEKEHAILVIYLNTPGGLLDSAMNIAIDIDKSTIPVIGFVVDKWAESAGTLIFVCTHIAAMQPGTIIGSMQPIEYDPTTGTYTLVNDTKIINPILKFLDEHAGNKDRNLTSIHDFVLENLNLGPQEALEYHVINYIAYNIDDLLRQINGTQVYLPGTNITYIINTSSYTLEYFDMNIREYIVHAISDPTLSTLMLSLGMMIILFGILSGHLGVVPAGILLLLLGFVGNGYSISATSILLILFGSILLVVEHFISSFGVAGGIGIVMIVLGIALAPTSIGFSFSEQYAQSVLYSAYAVGVVLGAITAFIIYKIIAVRRRKPFSWKLEGALGKAVDPISPDNEGFVVIDGEYWKAKSESESISPGDEVIVVKKEGPILIVRKRIEK</sequence>
</entry>
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    <accession>I0A2F6</accession>
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        <submittedName>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="AFH43163.1"/>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="115" mass="13218" checksum="1EC117420CDBC0F8" modified="2012-06-13" version="1">MPTRSIWLNNYERVTEVFSPELNTYVYFIDIFKQCKVLKNLECKEISSTEGKLSLFSCELKVEAINSAVSLEVLVDSEHDITQAISVHFSRSLPLDPQLLMKVKEEVSIFLDKNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2F7</accession>
    <name>I0A2F7_FERFK</name>
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    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_1176"/>
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    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:valine-tRNA ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anticodon_Ia_Val"/>
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        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
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        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
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        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
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        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
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        <property type="entry name" value="Valyl-tRNA_ligase"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="8">
        <location>
            <begin position="421"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH43164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="820" mass="96100" checksum="4FC82A69A69DE112" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2H1</accession>
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        <submittedName>
            <fullName evidence="3">Phosphoesterase, DHHA1</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ordered locus">FFONT_1190</name>
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    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH43178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43178">
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        <property type="gene ID" value="FFONT_1190"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DDH_dom"/>
    </dbReference>
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        <property type="entry name" value="DHH_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="192"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="303" mass="34898" checksum="DE6A603617067B23" modified="2012-06-13" version="1">MMRGIISHWDIDGIASAVILSINYGIPTRNIKLSSTIKIDKYFNEISKNKVQNVFITDLNPSFQIAENIIKIAEKKKIKLVWIDHHAWDEEAKNFLKTRGAEIIVDEKASCAAELVKNYLYGEQRPPSYIEDVLKLAIDDDTFSNKYEMTYKWRVLLRWGDWSIRYKTLESWIDGYIWPKWAQREFERIDLEYKKLIKSAIEASEYVQTEQGVIAFISSSEKLHPGDIVRELESEGKRPADLYVFIYDKGISLRSHKINVLQIASALGGGGHPYAAGISLIDDVQDKESIKSKIINLLKRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2I8</accession>
    <name>I0A2I8_FERFK</name>
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        <submittedName>
            <fullName evidence="3">2-oxoacid:ferredoxin oxidoreductase, gamma subunit</fullName>
        </submittedName>
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        <name evidence="3" type="ordered locus">FFONT_1207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1207"/>
    <dbReference type="EnsemblBacteria" id="AFH43195">
        <property type="protein sequence ID" value="AFH43195"/>
        <property type="gene ID" value="FFONT_1207"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
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        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="198" mass="22013" checksum="1E6BFE9DB545E482" modified="2012-06-13" version="1">MYPFQEELLNKDIIEVTWLGRGGQGAVTASELVAMSAIKEGKNAIAIPEFGAERRGVPVRAYTRVSKELKEIHKTPIVNPDIFVLLDPSLLSKAKNYIDLKDDGVVIANTQLSKDEAIKVMGIKVKEENFFVIDAKSIVMRILGRPIYNTVMVGAFIAIVPIVKLETVLESVRETFKGKLGDLNAQVIEEGYKHFLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2J7</accession>
    <name>I0A2J7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutamyl-tRNA(Gln) amidotransferase subunit E</fullName>
            <shortName evidence="6">Glu-ADT subunit E</shortName>
            <ecNumber evidence="6">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gatE</name>
        <name evidence="8" type="ordered locus">FFONT_1216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of GatD and GatE.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GatB/GatE family. GatE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1216"/>
    <dbReference type="EnsemblBacteria" id="AFH43204">
        <property type="protein sequence ID" value="AFH43204"/>
        <property type="gene ID" value="FFONT_1216"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1216"/>
    <dbReference type="eggNOG" id="arCOG01719">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OMA" id="SGFQRTM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00588">
        <property type="entry name" value="GatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004414">
        <property type="entry name" value="GatE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659:SF2">
        <property type="entry name" value="PTHR11659:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00134">
        <property type="entry name" value="gatE_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GatB_Yqey" evidence="7">
        <location>
            <begin position="492"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH43204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="643" mass="72774" checksum="46B19E691496D340" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-02-10" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2K7</accession>
    <name>I0A2K7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle 19 kDa protein</fullName>
            <shortName evidence="5">SRP19</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">srp19</name>
        <name evidence="6" type="ordered locus">FFONT_1226</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SRP19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1226"/>
    <dbReference type="EnsemblBacteria" id="AFH43214">
        <property type="protein sequence ID" value="AFH43214"/>
        <property type="gene ID" value="FFONT_1226"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1226"/>
    <dbReference type="eggNOG" id="arCOG01217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169299_1_0_2"/>
    <dbReference type="OMA" id="VIWPAYL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00305">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022938">
        <property type="entry name" value="SRP19_arc-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SSF69695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="102" mass="11857" checksum="2AC3E9EE8175A301" modified="2012-06-13" version="1">MSSRGFKGKKIVIYPSYLDCTSSRTHGRKIPKSLCVQKPSISEILEVAKGLSLNPILEDKKFPKKWWEIKQRVIVDKRWGKIETLKRICIAINDMRKKGKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2K9</accession>
    <name>I0A2K9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Glutamine synthetase</fullName>
            <ecNumber evidence="2 6">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_1228</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="2 6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1228"/>
    <dbReference type="EnsemblBacteria" id="AFH43216">
        <property type="protein sequence ID" value="AFH43216"/>
        <property type="gene ID" value="FFONT_1228"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1228"/>
    <dbReference type="eggNOG" id="arCOG01909">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_2"/>
    <dbReference type="OMA" id="VFPWESK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="7">
        <location>
            <begin position="102"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="3">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH43216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="465" mass="52964" checksum="C46AD145F5FDA016" modified="2012-06-13" version="1">MKIEELKNIIEDNKLKWINLQLTDLLGIFRQVVISSKMFDEDAINLGIGKLDGSSVYGFKEIYESDLTLRPVLDTLRTNPFEINTADIITEVFDTFGTKRLETDPRYVAQKTIAYTSSFGYNSLTAAELEFYIFDEIRSWLRPLFSGFEIKSGSAGYDEKTNHSLTIKGGYYVPPPFDESIKIRSEISDLLQDFYKITIESHHHEVGGAGQGEINMQALDPVSTSDNIQRIKYVSRFVAHKYGKIITFMPKPISDDAGNGMHVHVSLWNNGKNAFYDINDDYAGISQEARYFIGGLLSHGKALSAIVSPTVNSYKRLLPHYEAPIFLTWSKGNRSAAVRIPSYHKNYERRKRVEYRPPDPSCNPYLAISAIILAGIDGIVKKIDPGDPIDENIYKMAESKLRELKIERLPSSLDKALDELLNDNEFLRPAFSQSLIELYIELKRKEIEKINRTISPAEFYYYANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2L1</accession>
    <name>I0A2L1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription initiation factor IIB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1230"/>
    <dbReference type="EnsemblBacteria" id="AFH43218">
        <property type="protein sequence ID" value="AFH43218"/>
        <property type="gene ID" value="FFONT_1230"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1230"/>
    <dbReference type="eggNOG" id="arCOG01981">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043736_0_1_2"/>
    <dbReference type="OMA" id="NEYVCTR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="PTHR11618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="SSF47954"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CYCLIN" evidence="4">
        <location>
            <begin position="113"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CYCLIN" evidence="4">
        <location>
            <begin position="209"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="299" mass="33866" checksum="3EF2C3700ECB1016" modified="2012-06-13" version="1">MSDESSENKINCQHTIADMERGELICLDTGEVISTIIDSGPEWRDFSSQAERSRSRAGTPLTFRMHDHGLTTYTSESDIKKLPFRKRRKFIELKRKNTAIRMSKNKRMVKALQILNDEARKLGLPQKVTETAAYYIKKVVEKGLGRGEMIRAYVAASLFMACRLMKVPRTFYSVIISVGADEEKVRYAQRKIVEIQGGKINAKVTKPKDYIPMITSKLGLSMQSENLMYRLANAIEKLNMDHGKSPIALAAATAYIASSIFGEKKNQKDIASALGNFTDVAIRNRYREIIDKLYIEVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2M3</accession>
    <name>I0A2M3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase sliding clamp</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Proliferating cell nuclear antigen homolog</fullName>
            <shortName evidence="3">PCNA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcn</name>
        <name evidence="8" type="ordered locus">FFONT_1242</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 4">Belongs to the PCNA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1242"/>
    <dbReference type="EnsemblBacteria" id="AFH43230">
        <property type="protein sequence ID" value="AFH43230"/>
        <property type="gene ID" value="FFONT_1242"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1242"/>
    <dbReference type="eggNOG" id="arCOG00488">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043978_1_0_2"/>
    <dbReference type="OMA" id="TIRKDPN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
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        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCNA_N" evidence="6">
        <location>
            <begin position="13"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PCNA_C" evidence="7">
        <location>
            <begin position="183"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH43230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="251" mass="27899" checksum="21E5EA19BF762FD7" modified="2012-06-13" version="1">MNGLASVKIVYPDAKIFKSLFESMSKLIDEIRLEINENGLEIRAIDSANVALMSVSFPKESFSEFIINEKKSVGLNLSTLVKMMKRVRKEDRFEIEINEDEISLRLIGTTKREFKVNNLEVAIPEIPEGGIEFSTRLKVISETLKHALKDLELVGNQAIFEFDGNEKLMISSVGEGKYEMQLTKSSGSIIEVISGNPAKSTYSVEYLLNLLSLTKIADTISISFSSQMPIKLEIDLPTGGNISYLLAPAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2N5</accession>
    <name>I0A2N5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Daunorubicin resistance ATP-binding protein drrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1254"/>
    <dbReference type="EnsemblBacteria" id="AFH43242">
        <property type="protein sequence ID" value="AFH43242"/>
        <property type="gene ID" value="FFONT_1254"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1254"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="YRTGFWL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="3"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="236" mass="26499" checksum="4C1CACCAE2178D64" modified="2012-06-13" version="1">MLVTVRDLRKNYGEKEALKSISFNIDEGEIYGLIGPNGAGKSTTLRILATLLKPTSGEVYIDNINVAEEPEKVRKIISYLPEEAGAYPNMTGIEYLKYIAEIYGVDESFIEVGKEISGLGDALKDKIKTYSKGMKRRLQVARTLMVKPKLAILDEPTSGIDVLYSLQLRRSIKDFSKVKRITIILSSHNMLEVENLCDRVSFLYDGRLIVEGTPEEIKEKYDAKNLEEAFVRAVGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Q5</accession>
    <name>I0A2Q5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Acidic ribosomal protein P0 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpl10</name>
        <name evidence="2" type="synonym">rplP0</name>
        <name evidence="5" type="ordered locus">FFONT_1274</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1274"/>
    <dbReference type="EnsemblBacteria" id="AFH43262">
        <property type="protein sequence ID" value="AFH43262"/>
        <property type="gene ID" value="FFONT_1274"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1274"/>
    <dbReference type="eggNOG" id="arCOG04288">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053173_0_0_2"/>
    <dbReference type="OMA" id="MAHVAEW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00280">
        <property type="entry name" value="Ribosomal_L10_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022909">
        <property type="entry name" value="50S_L10_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="RL10_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="RL10P_insert"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RL10P_insert" evidence="4">
        <location>
            <begin position="120"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="347" mass="38406" checksum="8309E5F65C28F650" modified="2012-06-13" version="1">MSIMRLIVKQKVVPSWKEEEVNELVKLMKEYPVLGIIDAKDVPASLIQKIKVMLRDKVDDAIVIKSVKNNLFLIALEKADVKGKEKLKEVIKDQKIFVFSKLNPFMLAAMINRMRLPAPAKAGMKVDREIAVEPMDTHLQPGPLLSAFGKLKIPTKVQNGTIWIAKRTVLAKPGDVISADLASMLQRLGISPGEVGLSLQYALDDGVLLPAESLSLNIEEYRNSLIQSYIQAISLASEIAYPEPEALKLSLIKSYKRALHLSAEIGYITSDNAEYVLRVAASKAYSIVAAMGDKAKELGIEGVQLQRPPEGEKKEEKKEEKKEEKAEEEKKELSEEELSSGLGALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2T9</accession>
    <name>I0A2T9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1308"/>
    <dbReference type="EnsemblBacteria" id="AFH43296">
        <property type="protein sequence ID" value="AFH43296"/>
        <property type="gene ID" value="FFONT_1308"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1308"/>
    <dbReference type="eggNOG" id="arCOG00978">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025402_0_1_2"/>
    <dbReference type="OMA" id="VVYPKDA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016429">
        <property type="term" value="F:tRNA (adenine-N1-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="PTHR12133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="112"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="262" mass="29196" checksum="80A37965311A07BD" modified="2012-06-13" version="1">MRSGILLDEGMPVVLFFPDNTKKLVVLKRGKYTESKYGRIKHDDIIGKNLLGKFVKTNSGARILVQKPTIDEIIYSLFKRKSQVIYPKDAYAIISEAGLKRGDKVGEAGVGSGFLAAHILSIIGNEGEYYGYDLRDDMIETAINNLSLLGYDVSGKIRKKDVKEGIDESDLNAFFLDLPDPWNAVNAIYPSLAPDARIVIFVPTLNQVIKFLASIDDSSKFKINRIFETFSREYAVSKDALRPSPIQSSFTGYIISLVKISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2U5</accession>
    <name>I0A2U5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1314"/>
    <dbReference type="EnsemblBacteria" id="AFH43302">
        <property type="protein sequence ID" value="AFH43302"/>
        <property type="gene ID" value="FFONT_1314"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1314"/>
    <dbReference type="HOGENOM" id="CLU_2032765_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="121" mass="13729" checksum="A02BDFDEA946CCAE" modified="2012-06-13" version="1">MSDSKEGKKTVLKTASLGILSGVILIIIDLYFKNTLLSLKSYELLIGSIIIWMLTFFLKVFFYPTRFVLSFVISGFFLLFVYEVLIGRTEVVYAFLLGSLLGYLHSILKLTTETPSLKDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2V7</accession>
    <name>I0A2V7_FERFK</name>
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            <taxon>Archaea</taxon>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="94" mass="10694" checksum="FB69726C6662F227" modified="2012-06-13" version="1">MEDRKIEVPSEKLNEISKILRNIGEPNKLKILFLLKNGPLPVCVISYILGLDQTLISHLLKTLRDLGLIEYSRKGNFKLYSLSDSSIKVLDLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Z4</accession>
    <name>I0A2Z4_FERFK</name>
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        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH43351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1363"/>
    <dbReference type="EnsemblBacteria" id="AFH43351">
        <property type="protein sequence ID" value="AFH43351"/>
        <property type="gene ID" value="FFONT_1363"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1363"/>
    <dbReference type="eggNOG" id="arCOG03882">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="NECISYF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="239" mass="27148" checksum="B0EF36F345768CA1" modified="2012-06-13" version="1">MKWQEVIRNSRTEGLAEKCMLILASEDVAEETGVQPHLDFSSLTIYSESSDSYLEDYVAQNYSENIKILSEPPDSGSLPLESSYSEYLNMVLRELADLLIQVVKRTDSIDTEHALFLTKEGDLIVLEGERQKVVLPELKTCLFLHTHPNGVCLPSKRDIQSASSFFMNGGILFLILSSRCFFSMYRSSLINENDVYALKRLENEVEKAYLKSFNPIEYFNESLKGSNIKVRILPPPFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Z7</accession>
    <name>I0A2Z7_FERFK</name>
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        <recommendedName>
            <fullName evidence="1">HTH arsR-type domain-containing protein</fullName>
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    </protein>
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        <name evidence="2" type="ordered locus">FFONT_1366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="85" mass="9813" checksum="4A1E615DEF5D8853" modified="2012-06-13" version="1">MEEIVGSIGKVKILKVIYKLGEVNITRISRETGLNHKSVSIHLEELKKMGIVYERRFGRVRMLSLNYLNPKVLVLSDLLNFLNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Z8</accession>
    <name>I0A2Z8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATPase</fullName>
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    <organism evidence="2 3">
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1367"/>
    <dbReference type="EnsemblBacteria" id="AFH43355">
        <property type="protein sequence ID" value="AFH43355"/>
        <property type="gene ID" value="FFONT_1367"/>
    </dbReference>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022443">
        <property type="entry name" value="KaiC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010624">
        <property type="entry name" value="KaiC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
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    </dbReference>
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        <property type="entry name" value="KAIC"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KaiC" evidence="1">
        <location>
            <begin position="11"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="281" mass="32089" checksum="674C3DCCAD7AEEC3" modified="2012-06-13" version="1">MSETGQQAAVERLKTGVKGFDELIEGGIPRGFFISIVGEPGTGKTIFSIHFAWEGIKESDRVIYVTTEESKESIVQQASQFGMNFRKGLNEKKMIIIDALMKSKEEEWTLNDLNIEELVSKVIEAKKALGYGRTRLVIDSMSAFWIDKPAMARKMSYYIKRVLYKWDVTAYLISQYAVTTDLAYGFGLEHIADGIIRFKKILSRGVLKRYVLVEKMRQTNHDLTSHEVYIKPGIGMEIGPGTEKKREDFRINPEVAKKMVDAKNKGIREFLGEEESEWPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A302</accession>
    <name>I0A302_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sld5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ordered locus">FFONT_1371</name>
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    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43359">
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        <property type="gene ID" value="FFONT_1371"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sld5" evidence="2">
        <location>
            <begin position="44"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="186" mass="21939" checksum="89A79813AC0C518E" modified="2012-06-13" version="1">MEERLELLKQAFNNTSVKVIAVSDIDQTVLPNGAVLKAKKGEEVELPRWIANFLEERGLVKRKWDEISVQEVSKIHYREMSRRAVKDIEQLPSNFYWLVQEYLDYLEKKIRSEADPSFIEDRQNLLEFLSEIVEKRMRAVITYVFSYGDYTEISQKLTQEEIILAEELKNLLIQWKKIVIGGNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A306</accession>
    <name>I0A306_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PHP C-terminal domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1375"/>
    <dbReference type="EnsemblBacteria" id="AFH43363">
        <property type="protein sequence ID" value="AFH43363"/>
        <property type="gene ID" value="FFONT_1375"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1375"/>
    <dbReference type="eggNOG" id="arCOG00302">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072983_1_0_2"/>
    <dbReference type="OMA" id="AICDHDT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="229" mass="26251" checksum="8C94CC38B6EDE3FF" modified="2012-06-13" version="1">MERVRLSVDMHMHSNFSDGESDVESILLHAERIGLNAVSITDHNTFQGSFHASKVAKEKGIGIHVVMGSEVRTDVGDTLVYCREPIEIRKGMPFLELYDRARENSCFLAFAHPFDIFRNGISMGDLHRLWEKIDAIECFNSNSLFLTNSKAYRFAREHSIPCMASSDAHTLKNIGIFRMIVSLESSEDLYYSLFSSIKVGRVELIHRRVPISVRVDKLRWSIKRKLNMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A308</accession>
    <name>I0A308_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43365">
        <property type="protein sequence ID" value="AFH43365"/>
        <property type="gene ID" value="FFONT_1377"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1377"/>
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    <dbReference type="OMA" id="SDRNMAI"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002849">
        <property type="entry name" value="DUF131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01998">
        <property type="entry name" value="DUF131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="91" mass="9818" checksum="47629A71A8CF9CC0" modified="2012-06-13" version="1">MIDERSLLSIGFLLVFIGIIVIMGAFLYMFMKSPSSSSEVQGGGIIFIGPIPIIFGSSKNITKSLLIVAMVISLVLIVVYILSFLRGSGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A316</accession>
    <name>I0A316_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine decarboxylase proenzyme</fullName>
            <shortName evidence="10">AdoMetDC</shortName>
            <shortName evidence="10">SAMDC</shortName>
            <ecNumber evidence="10">4.1.1.50</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">S-adenosylmethionine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="10" type="primary">speH</name>
        <name evidence="11" type="ordered locus">FFONT_1385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>H(+) + S-adenosyl-L-methionine = CO2 + S-adenosyl 3-(methylsulfanyl)propylamine</text>
            <dbReference type="Rhea" id="RHEA:15981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57443"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="4.1.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="10">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.50" evidence="10"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_1385"/>
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    <dbReference type="KEGG" id="ffo:FFONT_1385"/>
    <dbReference type="eggNOG" id="arCOG00279">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125470_2_1_2"/>
    <dbReference type="OMA" id="VYTCGEH"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006557">
        <property type="term" value="P:S-adenosylmethioninamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00464">
        <property type="entry name" value="AdoMetDC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042286">
        <property type="entry name" value="AdoMetDC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003826">
        <property type="entry name" value="AdoMetDC_fam_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042284">
        <property type="entry name" value="AdoMetDC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
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        <property type="entry name" value="S-AdoMet_deCOase_pro-enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33866">
        <property type="entry name" value="PTHR33866"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02675">
        <property type="entry name" value="AdoMet_dc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56276"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03330">
        <property type="entry name" value="SAM_DCase_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="2 10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="9 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10" id="KW-0704">Schiff base</keyword>
    <keyword evidence="4 10" id="KW-0745">Spermidine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023439550" description="S-adenosylmethionine decarboxylase beta chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023439551" description="S-adenosylmethionine decarboxylase alpha chain" evidence="10">
        <location>
            <begin position="81"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for processing activity" evidence="10">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for catalytic activity" evidence="10">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autolysis" evidence="10">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH43373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="142" mass="16268" checksum="674DA92F8A204F0B" modified="2012-06-13" version="1">MEQAEEKSNIKTIDLQDMVVGKHVYGNLYDMDPKILGDEEYIRNIMLEAVKKANATLFDVRSWSFPGKKGGVSVLILVLESHLAIHTWTEYRYATLDIYTCGPHTHPEAAFDFVVEKLNPKKVVKHKTFRLSNVEAEPLLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A322</accession>
    <name>I0A322_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Silent information regulator protein Sir2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1391</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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            <taxon>Archaea</taxon>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_1391"/>
    </dbReference>
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    <dbReference type="OMA" id="EQCKKCR"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
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        <property type="entry name" value="Sirtuin"/>
    </dbReference>
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        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SIRTUIN"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="262" mass="29145" checksum="8E7C01C6B82E5DA8" modified="2012-06-13" version="1">MSAEEKLAKTLIDAGGKALFFTGAGASTESGVPDFRGPQGLWKRIPPEVFDIDLFYRDPEYSWRIYAEYVYSQISRASPNRAHIVIAELESLGLVEAVITQNIDKLHQKAGSKKVIELHGTYDKVQCLRCGFHGDIKDFIEDFIREKRVPRCPKCGRILKPAVVYFGEPLPSEELSSAFSLAKSSKLIIVVGSSLSVYPAALIPEIALDHGAKLFIINESPTHLDKDAELVVREKAGTFLEKVSNAVEEMMKSSKQKDESLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ41</accession>
    <name>H9ZZ41_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0001</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH41998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH41998">
        <property type="protein sequence ID" value="AFH41998"/>
        <property type="gene ID" value="FFONT_0001"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0001"/>
    <dbReference type="eggNOG" id="arCOG11614">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_470633_0_0_2"/>
    <dbReference type="OMA" id="TEFNDWF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH41998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="599" mass="68532" checksum="57703FAF352C43E0" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ52</accession>
    <name>H9ZZ52_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0013</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42009">
        <property type="protein sequence ID" value="AFH42009"/>
        <property type="gene ID" value="FFONT_0013"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0013"/>
    <dbReference type="eggNOG" id="arCOG06985">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192649_0_0_2"/>
    <dbReference type="OMA" id="PWRFRFY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="71" mass="8454" checksum="5E9F15AE97E823DF" modified="2012-06-13" version="1">MIKCPVCGHEGNEGEFKLFKEPWKFRFYDVKRLECPKCHAIFNYYSGTSPKGRKSEFVIKVKPREVKRVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ91</accession>
    <name>H9ZZ91_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Anaerobic ribonucleoside-triphosphate reductase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0053"/>
    <dbReference type="EnsemblBacteria" id="AFH42048">
        <property type="protein sequence ID" value="AFH42048"/>
        <property type="gene ID" value="FFONT_0053"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0053"/>
    <dbReference type="eggNOG" id="arCOG00952">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078147_2_1_2"/>
    <dbReference type="OMA" id="CPFCHNW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012840">
        <property type="entry name" value="NrdG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01094">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02495">
        <property type="entry name" value="NrdG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="15"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="253" mass="28556" checksum="C959FEF672583FDB" modified="2012-06-13" version="1">MSDARLIGAGWKSISLIDVVDSVTFTVWLCGCNLSCPFCHNWKLAGNNPERCDFLDNRRLLEDVEASRGLIDFLHVTGGEPLVQYIELGKLLRTLKESYGIEVSLNTNLTLTSPLSRIIEEDLVDHLATDFKVPPDKMFGLSSLLAQKLWQKYEEGLSLVADHQLPLELRIPIAKFTTPELLGEYLRRVERSLSRLSKLVIVINPLLGEPATTPRDREWCSSHCNPSNDRLDEIAESVKKLGFEVKIKKWVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZB4</accession>
    <name>H9ZZB4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CRISPR type III-B/RAMP module-associated protein Cmr5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0077</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR system Cmr5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0077"/>
    <dbReference type="EnsemblBacteria" id="AFH42071">
        <property type="protein sequence ID" value="AFH42071"/>
        <property type="gene ID" value="FFONT_0077"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0077"/>
    <dbReference type="eggNOG" id="arCOG02654">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1478857_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023101">
        <property type="entry name" value="AF1862-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010160">
        <property type="entry name" value="CRISPR-assoc_prot_Cmr5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09701">
        <property type="entry name" value="Cas_Cmr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158568">
        <property type="entry name" value="SSF158568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01881">
        <property type="entry name" value="cas_Cmr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="182" mass="20958" checksum="3C54935C6C9302F0" modified="2012-06-13" version="1">MKEMGNAYELKDPNVRLMEELIEIFDYLSKVAESKDKDVKEYLKALRSRARDAPTEIFTSGLALFTVTYLAKSKDCFPKMANELSKSPDRDILLKNLEKKLIVTDDGQEKKCESPDFGYGSYLLILMYLLKRQRIVGENTNLKDFLKMASSYPPLSEKALIISELIKRFSEAYLPEPESEQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZD9</accession>
    <name>H9ZZD9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0103"/>
    <dbReference type="EnsemblBacteria" id="AFH42096">
        <property type="protein sequence ID" value="AFH42096"/>
        <property type="gene ID" value="FFONT_0103"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0103"/>
    <dbReference type="eggNOG" id="arCOG05851">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG07844">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_402608_0_0_2"/>
    <dbReference type="OMA" id="PPWPFDI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="683" mass="74820" checksum="2D29AE9A002244EB" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZF1</accession>
    <name>H9ZZF1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative ATP-fructose-6-phosphate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0116"/>
    <dbReference type="EnsemblBacteria" id="AFH42108">
        <property type="protein sequence ID" value="AFH42108"/>
        <property type="gene ID" value="FFONT_0116"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0116"/>
    <dbReference type="eggNOG" id="arCOG00014">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_2_2"/>
    <dbReference type="OMA" id="ECALIVL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="318" mass="34886" checksum="59C74DEF707CCA4D" modified="2012-06-13" version="1">MKSFLKSGNSGKFGVHVSVGNLNIDIISSVPELPAEDDSVKAKSLFIGAGGGALNYSVAASRFGHTSYLIGITTPIFSSLGFFRYLIENGVKIDNVKIVEEGSPGVSNIIHLPNEQRRIISYRGVNNLLDDDYIARSVEKINSVDVVHFSSVKSSVALSAIKKIKEKRVLKSPIFSLDPGTESREYEKVIGEFTGLVDVLFLNEKFARNVWGYGFADFLYDMSWKTIVALKLGERGAEAFYEGKRTSRILKKVEYVDTTGAGDAFDAVFNCALIETRSVEESLELAVTAGALKSRNIGASSSPFRSEVFEKKREILLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZG8</accession>
    <name>H9ZZG8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enolase</fullName>
            <ecNumber evidence="7">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">eno</name>
        <name evidence="12" type="ordered locus">FFONT_0133</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cell surface</location>
        </subcellularLocation>
        <text evidence="7">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="7"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0133"/>
    <dbReference type="EnsemblBacteria" id="AFH42125">
        <property type="protein sequence ID" value="AFH42125"/>
        <property type="gene ID" value="FFONT_0133"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0133"/>
    <dbReference type="eggNOG" id="arCOG01169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_2"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Enolase_N" evidence="11">
        <location>
            <begin position="9"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase_C" evidence="10">
        <location>
            <begin position="142"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7 9">
        <location>
            <begin position="370"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7 8">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="7">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH42125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="430" mass="46920" checksum="50A755E86569FDA1" modified="2012-06-13" version="1">MIDSSDFAITEISAYEILDSRGDPTLRVCVSTKKARGCANVPSGLSKGKHEVAELRDGIGKLGGKGVSKAVETVKDYILQALVGEDVREQQKIDRIMMSLDGTEDKSKLGGNTMLGVSLAVARTAAILTSQELYSYLGGVGEFILPVPFLNIINGGKHASSGLDFQEFMIVPVGFDTFKDAIWASSEVYHKLKEIIKEKYGGIHTSVGDEGGFTPPIRDPEAAVILLEDAIKASGYAVGDNFYIAIDAASSNFYNEEKGVYTVNGKNYRKDELLEFYLKLIDAHPVKSIEDPFYEEDFESFSELNSKLRKKGVLVVGDDLLTTNPKRLEKALEKGSVSGVIVKPNQIGTLTETIRFSEMAMHSGIKAIVSHRSGETDDPFIADLSVALRNGAIKAGAPCRGERTSKYNRLIEIESLLSGYSEFAGRRFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZG9</accession>
    <name>H9ZZG9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0134"/>
    <dbReference type="EnsemblBacteria" id="AFH42126">
        <property type="protein sequence ID" value="AFH42126"/>
        <property type="gene ID" value="FFONT_0134"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0134"/>
    <dbReference type="eggNOG" id="arCOG04323">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2177997_0_0_2"/>
    <dbReference type="OMA" id="CGYKWRG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="108" mass="11890" checksum="FBFD1F0AF768C609" modified="2012-06-13" version="1">MVKKEKKPNVCPRCGTEVPNPTKTWNFVSPLPDDKGRITITVMGSYKCPNCGYSWKAAISKLKVGGGEVEIDAGGKEKKIAGEAPKQKPEEIELDLEDIINEDDINEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZH1</accession>
    <name>H9ZZH1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Putative methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="2">M1Pi</shortName>
            <shortName evidence="2">MTR-1-P isomerase</shortName>
            <ecNumber evidence="2">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">MTNA-like protein</fullName>
            <shortName evidence="2">aMTNA</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0136"/>
    <dbReference type="EnsemblBacteria" id="AFH42128">
        <property type="protein sequence ID" value="AFH42128"/>
        <property type="gene ID" value="FFONT_0136"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0136"/>
    <dbReference type="eggNOG" id="arCOG01123">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_2"/>
    <dbReference type="OMA" id="RLWVDET"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1 2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="66"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="266"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="2">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="364" mass="40709" checksum="4F61C34B855C067E" modified="2012-06-13" version="1">MSILSELDSVKKELQEVLKEVSIVPIEWKDGKLRWIDVTSLPWEERYVESSDIYRVAEAIKRLEIRGAPAIGVTTALAVAMVAYNSPNNKDEMMKNIEKAVEILSHTRPTAYNLFWALNIMKKTFYESIDLSPQEIKEKLLSKALKIQIEDIKNNLKMGEIGEKLIQDGDTILTHCNTGSLATAGHGTALGVIKTAWKNGKKIKVIATETRPLLQGARLTAWELKKEGIPFKLITDNMVGIVMMKEMVHKVFVGADRILRTGHVINKIGTYGIAVLASYHKIPFYAVAPTSTFDLTTSPEDVIIENRDESEVTTVLNKLRIAPEGTSAYNFAFDMTPPELVSGIVTEKGIVEKDYESNIKKLFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZH3</accession>
    <name>H9ZZH3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0138"/>
    <dbReference type="EnsemblBacteria" id="AFH42130">
        <property type="protein sequence ID" value="AFH42130"/>
        <property type="gene ID" value="FFONT_0138"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0138"/>
    <dbReference type="eggNOG" id="arCOG01252">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_2"/>
    <dbReference type="OMA" id="HGIGYYP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="1">
        <location>
            <begin position="36"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="506" mass="56969" checksum="5648734BC49E01D2" modified="2012-06-13" version="1">MNKDDRDFFSDIFEENKLGKRYKAFVLGKWIFGREEEQIFSPIDTNTIGTIPKLTYDDIEPYIKELYESGKWKIRNTPGYKRIEYLEKMAKLIEEHREDFIESLMIGAGKTRDQAAGEVNASINRLKSAMLDLRKVYGEYIPGDWDQTTLESESLVRKEPYGIVLAISPFNYPLFDTVAKFTYSVVAGNAVIIKPPTQVPVPSLMFARIAEVSGFPKESLMVLTVPGSEMEKVVSDPRIGVISLTGSSETGKKVLKAGGIKRYIMELGGGDPAIVLDDADIDEASRLISTGIYSYAGQRCDAIKMIIAHHSVKDELKKKIVENLAKVKVGDPRDPNTTMGPLISKKAVEEMMKGIQDAVEKGGKILYGGRRLNGNYVEPTLIEITDKSKLNSLLLYKEEVFAPVAIIFNYANEDEAVMLANNRKYGLDASIFAKDINRIRKIIRYLEYGAIYINDIPRHGIGYYPYGGRKESGIGRESIAYSIEEVMAIKAIVYNYRGRRIFEYLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZH8</accession>
    <name>H9ZZH8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Gumerov V.M."/>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="384" mass="44972" checksum="8F408D1990B44979" modified="2012-06-13" version="1">MSKGERKLETDYTLELWDSTVFLRPSLNMKYLYIELTTRCNLKCKMCFKQYWEDKEGDMDYNLFLKILNDTQEFPSIKMIFLGGIGEPTVYPKFTDAVKEIKDRGYALGLSTNGTLLNKSLIDFLINEQVDLIYFSMDALPVQSNQVRLGHVTSEITGANIKKIIEEKKRRVLPKPSISVEVVATKENYKQLPEMAKYLNELGVDSMLISNLLPMTEEQVNDIVYDGKVDMSKIVDELEKISSYGIYIKIPYFELKTERRCEFDENNAVVIRWDGEVSPCYRFLHTYYEYIFGRKKKVNAYSFGNVKNRSLKDIWLDPKYSKFRFVMKNYMYPSCTDCPLRNACDFVKTSDIDCWGNEPSCADCLWSRRLIFCPIPQYMYGKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZP3</accession>
    <name>H9ZZP3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0209"/>
    <dbReference type="EnsemblBacteria" id="AFH42200">
        <property type="protein sequence ID" value="AFH42200"/>
        <property type="gene ID" value="FFONT_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0209"/>
    <dbReference type="eggNOG" id="arCOG05956">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2230267_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="105" mass="12073" checksum="3ACE06BC2E1052A6" modified="2012-06-13" version="1">MRKPWQEEFTYSVIDLYLFNKGDLNSVSQILPMGLKAFGSELTDYIIKNTIKEANGDFYCGICSKGPFSKKGIKLHLLRVHQKDILEIIDEFVMSRISAIKKSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-02-19" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZS3</accession>
    <name>H9ZZS3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Riboflavin kinase</fullName>
            <shortName evidence="17">RFK</shortName>
            <ecNumber evidence="5 17">2.7.1.161</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">CTP-dependent riboflavin kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16 17">CTP:riboflavin 5'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Flavokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">ribK</name>
        <name evidence="19" type="ordered locus">FFONT_0239</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="20" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 17">Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>CTP + riboflavin = CDP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25021"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.1.161"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (CTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the archaeal riboflavin kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.161" evidence="5 17"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0239"/>
    <dbReference type="EnsemblBacteria" id="AFH42230">
        <property type="protein sequence ID" value="AFH42230"/>
        <property type="gene ID" value="FFONT_0239"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0239"/>
    <dbReference type="eggNOG" id="arCOG01904">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088476_0_0_2"/>
    <dbReference type="OMA" id="AYYVRQY"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00929"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01285">
        <property type="entry name" value="Riboflavin_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039063">
        <property type="entry name" value="RibK_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023470">
        <property type="entry name" value="Riboflavin_kinase_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023602">
        <property type="entry name" value="Riboflavin_kinase_CTP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40706">
        <property type="entry name" value="PTHR40706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01982">
        <property type="entry name" value="CTP-dep_RFKase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 17" id="KW-0288">FMN</keyword>
    <keyword evidence="12 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="18">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="101"/>
            <end position="106"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="201"/>
            <end position="204"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="AFH42230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="226" mass="25640" checksum="E56960637DCFA784" modified="2014-02-19" version="1">MNYEDARFGMLLILIFDGKKRTRTTQKALSEKIGLSQQSISRILRELEAQGIIYRIVEGKGEYLEITEKGLKLVETLWSKAESIVKEEKDVLILEGEIVEGLGEGRFYIKLPYYSKKIQELVGFVPYPGTLNVRLKGESVLKRAFLNPEKGLRIEGFRNEERYYGGATLFPVKVNGYERAAIIIPDRTSHEKDIIEIVAPDYLRGELGLKNGSKVVLEIKTKSVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZT5</accession>
    <name>H9ZZT5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallopeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_0251"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0251"/>
    <dbReference type="eggNOG" id="arCOG04217">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136010_0_0_2"/>
    <dbReference type="OMA" id="PHGKYVN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043998">
        <property type="entry name" value="Put_Metallopep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18894">
        <property type="entry name" value="PhageMetallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhageMetallopep" evidence="1">
        <location>
            <begin position="3"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="137" mass="15529" checksum="3851731796F47588" modified="2012-06-13" version="1">MIKYKRCYEIREVAKGIALDSDLKINFNNIAFVVSHGAKSNAYARIYGLSKAIQIGHVLPPLYTIEFLCNKIKSLNEREITGVLIHEFLHIPYNMSGGLRPHGNIVNSKNVKILLNRVSEDKMAKFYSLIKKCCSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZV3</accession>
    <name>H9ZZV3_FERFK</name>
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        <recommendedName>
            <fullName evidence="7">UPF0056 membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UPF0056 (MarC) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0270"/>
    <dbReference type="EnsemblBacteria" id="AFH42260">
        <property type="protein sequence ID" value="AFH42260"/>
        <property type="gene ID" value="FFONT_0270"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0270"/>
    <dbReference type="eggNOG" id="arCOG01997">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079909_2_1_2"/>
    <dbReference type="OMA" id="IRMIFPQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002771">
        <property type="entry name" value="Multi_antbiot-R_MarC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33508">
        <property type="entry name" value="PTHR33508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01914">
        <property type="entry name" value="MarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="206" mass="22470" checksum="457C1EDFDE25537C" modified="2012-06-13" version="1">MSIYMNISASEIIVLSLQLYAVMNPLVAIPKFTDLVESNQREGFFSITNKVFLTILFLSTIFVLAGGYILSFFGISYYSLKIAGGIILLTVAIDTLTTGHKPKEVETGDLIVVPIATPLIIGPGTMTSLIIFGELHGIINTLLAAYLSCFFVYLTLIVSIALLRLLGPTFINGLGKFMSLIIASFAIQMLLSGFYGYIIETYQVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZW3</accession>
    <name>H9ZZW3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dihydroorotase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_0280"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_1_2"/>
    <dbReference type="OMA" id="QHAQEPR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016812">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
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    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="4">
        <location>
            <begin position="47"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="418" mass="46891" checksum="7EE8D059563F91B5" modified="2012-06-13" version="1">MLKALIGKELKELTLIIEDGIVSKRLLNTDEAICRNIECIDLREKGIALPGFIDLHAHLRGLELSYKEDEESGTKAAARGGFTGIVDMPNTKPKIDNTKSLNLKIKSLYEKAYVNFGISVTIGKDVDDFIEMLKAKEVVSVGELFPEEHERLPEILKSFVANGIEKPIIIHLEHKDALGECGKGKRWACRPIESEMLALKEIGYMLESARIKAKLHITHVTNKYVYEMAKKYKFTTDTCPHYLYLSSEDEEKFGCLAKVNPPLRTRDIAKELIGLLPHFDAISTDHAPHSIEEKSLPFEKCPSGIASIEIAVPLMINLVNKGILNLEDLIQLLSMGPHKILNMKPGWGCFDIGCKANYTVVDLDKEWKIDSSKFYTKARFSPYDGLIIKGDVSSTIINGTVVYLDGEIIERPKISYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZX1</accession>
    <name>H9ZZX1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small-conductance mechanosensitive channel-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0288"/>
    <dbReference type="EnsemblBacteria" id="AFH42278">
        <property type="protein sequence ID" value="AFH42278"/>
        <property type="gene ID" value="FFONT_0288"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0288"/>
    <dbReference type="eggNOG" id="arCOG01573">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115707_0_0_2"/>
    <dbReference type="OMA" id="FGWQIVK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="42"/>
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        <location>
            <begin position="54"/>
            <end position="76"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="97"/>
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    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="204" mass="21945" checksum="7257ABC3634253C7" modified="2012-06-13" version="1">MSSNRKEIAKKFTYSIYKLTLWIAAYIIISALINGYVFKLLAEHNLNVSSYSSYINIPLAILFGYLIVASLSDVIYWNLRFKYDHSAAAGARNAIKIIGIGAILSSIAGGVAGGTAGVALGGFLGLVVGYASQQVLGQAISGLFLLTIRPFKIGDKVNIVGEDGEVLDIGVMFILLKKSDNTLVYIPNNSVISQKIYKKEIASS</sequence>
</entry>
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    <accession>H9ZZX7</accession>
    <name>H9ZZX7_FERFK</name>
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42284">
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        <property type="gene ID" value="FFONT_0294"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PTHR36697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01941">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="405" mass="45782" checksum="4956F1E5B2AD82DC" modified="2012-06-13" version="1">MTKNIYVEEVEWQLPQDMEIELVERKGIGHPDYIADSASEEVSIGLSNYYIEHYGRILHHNVDKVLIVGGQSDPKFRGGRVLHPIYILVSGRATTTVKTDDGIENVPIGTIIMSSVKKWIKNNMRYLDPEEHVIVDYKIGKGSEDLTGIFDRGLSVPHANDTSFGIGFYPYSTLENVVYQTERFLNSPEMKKKIPELGEDIKVMGLRNKKEIDLTIAGAMISKLVDDKDHYINIKEKVVEEVYKYTERLAPEYEIKIFFNTGDSPEKNIFYLTVTGTSAEHGDDGATGRGNRANGLITPMRPMSLEATAGKNPVNHVGKIYNIIAMLASKKIYEELHEEAHVIVQILSQIGRPIDDPLATSIKLTSKTKPITNDMKEEARNIIEQELKEITKYTKLILEKKVQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
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    <organism evidence="1 2">
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0318"/>
    <dbReference type="EnsemblBacteria" id="AFH42308">
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        <property type="gene ID" value="FFONT_0318"/>
    </dbReference>
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    <dbReference type="HOGENOM" id="CLU_1340695_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="204" mass="23918" checksum="72DF09B720FC0095" modified="2012-06-13" version="1">MVKILSHANVIIPMIFFEVKKDNERISSYVMENHYLCQLDEKERIILASKISPLDVSKINVTWFNSGFEHTLSMCINYKDIETHVKNWYNKASEDRYNDAKKEGGYVKKFLTTELNRIFLGGIFNKYNMPKGGKISKDYFLLGIYDEIFGKDFSIIRKDGFFVKAEVDKNLNAVRILDKRLKNIEKMLNLLIKKEKISIQKDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A002</accession>
    <name>I0A002_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0219 protein FFONT_0319</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ordered locus">FFONT_0319</name>
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    <organism evidence="3 4">
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    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. UPF0219 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0319"/>
    <dbReference type="EnsemblBacteria" id="AFH42309">
        <property type="protein sequence ID" value="AFH42309"/>
        <property type="gene ID" value="FFONT_0319"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0319"/>
    <dbReference type="eggNOG" id="arCOG01767">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
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        <property type="entry name" value="FabH-rel"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACP_syn_III_C" evidence="2">
        <location>
            <begin position="229"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="359" mass="38826" checksum="D7595B05FE2AF2C4" modified="2012-06-13" version="1">MKILIRIFPESKAGIIGWGAYIPIYRIKVEEIAGMWGNDLESIKGLNVEEKSVAGIDEDAITMGYEAAKNAIKRALINPKQIEAVFFGSESKPYAVKPSATVIADALGITPTTMASDLEFACRAGSEGIRASIGLVSSQMVNYALVIGSDTAQANPGDVLEYTASSGAAAFVIGPSNEAVAVFEASYTYVTDTTDFWRRSLSPYPLHGEAFTGDPAYFDHIVGAVKGLLNKTGLKVEDFDYAIFHQPNGKFPLRVAEKLGFPKEKVFPSIVVNKIGNTYNGSALLGLSKILDSVDPGKRILVAPFGSGAGSDAYSIVTTDKIKNKRDLAKKVSDYIEKKTYINYSTYSRYRNLIKKIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A045</accession>
    <name>I0A045_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0362"/>
    <dbReference type="EnsemblBacteria" id="AFH42352">
        <property type="protein sequence ID" value="AFH42352"/>
        <property type="gene ID" value="FFONT_0362"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0362"/>
    <dbReference type="eggNOG" id="arCOG07192">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189637_0_0_2"/>
    <dbReference type="OMA" id="NSRMITY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="81" mass="9365" checksum="2A332230D4356C9B" modified="2012-06-13" version="1">MEGVKIKSIWRNLPLQEIIYRVLQLKNGISTDKELYEAVNNAAEVSYSEFLKTIMKMELYGLLKTSLIKEDVLSIELNKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A062</accession>
    <name>I0A062_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-box-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Box A-binding protein</fullName>
            <shortName evidence="5">BAP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">TATA sequence-binding protein</fullName>
            <shortName evidence="5">TBP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">TATA-box factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">tbp</name>
        <name evidence="6" type="ordered locus">FFONT_0379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TBP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0379"/>
    <dbReference type="EnsemblBacteria" id="AFH42369">
        <property type="protein sequence ID" value="AFH42369"/>
        <property type="gene ID" value="FFONT_0379"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0379"/>
    <dbReference type="eggNOG" id="arCOG01764">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060161_4_3_2"/>
    <dbReference type="OMA" id="NCEYEPE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04518">
        <property type="entry name" value="TBP_archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033711">
        <property type="entry name" value="TBP_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="PTHR10126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="repeat" description="1" evidence="5">
        <location>
            <begin position="20"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="2" evidence="5">
        <location>
            <begin position="111"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="206" mass="23554" checksum="ECEC530DAEA85E5B" modified="2012-06-13" version="1">MLMVCYMKKTNSISKPVVQIENIVATVTLDQQLDLHEIERKVPRVEYNPDQFPGLVFRLDRPKITALIFKSGKMVVTGSKSTQELITAVKRIIKTFYNHGIKITGRPKIQIQNIVASANLNVDVNLEDAAYKLENNMYEPEQFPGLIHRMTDPYVVLLIFSSGKMVITGAKREEEVSKAVENIYKTLKELDCLVTKSEDEQEEEFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A069</accession>
    <name>I0A069_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0386"/>
    <dbReference type="EnsemblBacteria" id="AFH42376">
        <property type="protein sequence ID" value="AFH42376"/>
        <property type="gene ID" value="FFONT_0386"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0386"/>
    <dbReference type="eggNOG" id="arCOG04301">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062816_1_0_2"/>
    <dbReference type="OMA" id="ECQEVYD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003933">
        <property type="term" value="F:GTP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003801">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2/MptA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36445">
        <property type="entry name" value="PTHR36445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02649">
        <property type="entry name" value="GCHY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="275" mass="31845" checksum="5F92E5A0E2652D5F" modified="2012-06-13" version="1">MTKFSPDIHENPPEYKIAINKAGIEGLKKKIKIKIGNSCSEKLCTINLYIDLDKELRGVHLSRLVNSLNQELNSNECFKLNDLLEKTAKRVLNTHFSSSRSEIHVSFEDIIEDTRFVLHASYVREKNGSQEGKVSIELNGITSCPCAKEVFKFYENTEYEKTPTHMQRAELHITLNSKYNLDLLYNEYLLKAISVGKSSFSDILKETLNRDEEYEFIKKTINNPMFAEDVCRKAYFYLKKELPSDIGLKIKVISYESIHPYNVIAEVSDLEEHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0A9</accession>
    <name>I0A0A9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase U62, modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0426"/>
    <dbReference type="EnsemblBacteria" id="AFH42416">
        <property type="protein sequence ID" value="AFH42416"/>
        <property type="gene ID" value="FFONT_0426"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0426"/>
    <dbReference type="eggNOG" id="arCOG00322">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_4_1_2"/>
    <dbReference type="OMA" id="TCLWYIR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD_C" evidence="1">
        <location>
            <begin position="219"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="443" mass="50012" checksum="FA6E52B153A8B1C1" modified="2012-06-13" version="1">MSGEINNIAEDVAKKMKKGGFDDVVVKITYLEETMTKAANNTITITQNWSNKRLDLYLAKDKRISVMSTHFSSFEDIGKILDSSSNVISKIQPSELYAELPKPNAEHSSKILDIKVIEKMSEVPVYMQKMIEKSLESGAEKVAGVLSFIKEEKVLSINGEENFNEVSTAVKTYIRSFKGEKSGMWSFGSRYLDEKELLNTSEKATQFALLQNKKEKIDSGKYDIILSPLIAGNLLNYIMFSASAFNALAGLSFFKNNENNMYSEQLSLYDSPEETDLPGSTKFDDEGLATYTKPIIEKGMFKTFLHNSKTAKKFNTKSTANAGMLAPINWNIKVNTGDSSLEEMIRETKLGIFFNNNWYTRLHNYAEGIFSTAPRDAILLIKNGEIVGYLDRIRIADSFSNLLKKISMLSKDIYKIWWWEVSIPTKVPYIKVDSIRIATESLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0B8</accession>
    <name>I0A0B8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <dbReference type="Proteomes" id="UP000007391"/>
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    <sequence length="398" mass="45239" checksum="042456F0B5061A0A" modified="2012-06-13" version="1">MMSGILSNPSISEAYADDAKKLSEYISKDLPIFISAYPDKMSTHAGIFLASSLSLTRKKCFLKITYDKELSEEGLNILIGYNGMQNSSNEKVIVIPKTKSIQLKPSIDVIQFNPVYSILQILEGSMLIDQDKKVAVYSSIYQELKTPFETEHLISSYLSFTQLKILKKSLNLIGGSEKSLIDSLFFTIDPFYPSFSVADPGFIKQILEKEGIDPYLNYTQQSSEKVKRIAELLLNEYKKIDPNAGGKDLIRVSISATLNNIDFDLKEIAESIDIALEVSPASLYLFYAGMLPLHGLMVHRNFYIKIIADVFKKFLKKEDMTFEGNFLKIKCNEVMPVSFIGDFFRNRRLVDSKKIVVCERDGKLYTSIFELSNLDNETRNKILKSSNKLTFPYIEIIR</sequence>
</entry>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <location>
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    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00670"/>
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    </evidence>
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            <dbReference type="EMBL" id="AFH42434.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    <sequence length="142" mass="16956" checksum="8DEB70B6BEB1433A" modified="2012-06-13" version="1">MGDLEVIKNIYVVLDTNFLFMHLRKFDVFEEISSLINYKPEFICLESVLNELEKLERKNRKNDNEIKKRIGLIKEKCELQKSNYFSADKDILEIALNLTEKGIVIVATNDRELRRKLRQIGIKSIYYRESENSLETDFEFWL</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS2 family.</text>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42449.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="220" mass="25112" checksum="95C941A41B1DDD9B" modified="2012-06-13" version="1">MKNLSNEESKMVSEIHEKAFELLVPIEQYLAAGVHIGTYVCNKNMKEFVYRIRPDGLYVLDVRKIDERLRIASKMLARYEPQKILVVSVRQYGHNPVKKFSQYVGSKYIAGRVIPGILTNPHLEWYIEPDIVVVTDPRADQQIINEASKIGIPIISFTDTDNRIDNIDLIIPANNKGRKSLALLYWILTRQILREKGLLLQNADLQEPPDAFEARVGGKA</sequence>
</entry>
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    <accession>I0A0G2</accession>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
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        <property type="entry name" value="YjbQ-like_sf"/>
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        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="137" mass="15659" checksum="DBD17FD34F72956E" modified="2012-06-13" version="1">MKTFVKSISIDTKNRRELVNITSFVEQAVKESGINNGIVLIFVLHATATIVVNEDEQGLKKDIINWIDEFLDKERKYYHNLIDNNADSHIAASFFGPSKVFPLVNGKLIKGTWQEIMLFELDGPRNRRQVLIEVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0I3</accession>
    <name>I0A0I3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps5</name>
        <name evidence="8" type="ordered locus">FFONT_0500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit. Contacts protein S4.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 6">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0500"/>
    <dbReference type="EnsemblBacteria" id="AFH42490">
        <property type="protein sequence ID" value="AFH42490"/>
        <property type="gene ID" value="FFONT_0500"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0500"/>
    <dbReference type="eggNOG" id="arCOG04087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_0_1_2"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_A">
        <property type="entry name" value="Ribosomal_S5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_S5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="S5 DRBM" evidence="7">
        <location>
            <begin position="54"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="212" mass="23223" checksum="D3F730387B09B0AF" modified="2012-06-13" version="1">MAFEAQGVSLEEWVPRTKVGKMVKEGKITSINELFEMNLPILEPEIVDFLLPNLQHEVIDVGIVQKQTDAGELSRFKTVVVIGNGNGFIGIGTGKAKQLRYSIEKAITNAKLNIVPIRRGCGSWECMCGSPHSVPFITRGKSGSVEIVLYPAPKGTGLVAGDIAKIVLRLAGIKDVWSKSFGETRSTYNFAKATYNALKNTYSFVTQDDWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0I8</accession>
    <name>I0A0I8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">30S ribosomal protein S8P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0505"/>
    <dbReference type="EnsemblBacteria" id="AFH42495">
        <property type="protein sequence ID" value="AFH42495"/>
        <property type="gene ID" value="FFONT_0505"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0505"/>
    <dbReference type="eggNOG" id="arCOG04091">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_1_1_2"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="131" mass="14671" checksum="E2F16B7076A1F7D2" modified="2012-06-13" version="1">MLDTLSNALNELTNADRRAKKEVIISPASRLIIQTMRLLQSEGYIGEIEYIDDGRQGKLKIQLLGRINKAAAIKPRYSLKVSELSALPEWLKKKLPSREIGILIISTSKGIMSHHQTIKENIGGILLGYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0J3</accession>
    <name>I0A0J3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl14</name>
        <name evidence="5" type="ordered locus">FFONT_0510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0510"/>
    <dbReference type="EnsemblBacteria" id="AFH42500">
        <property type="protein sequence ID" value="AFH42500"/>
        <property type="gene ID" value="FFONT_0510"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0510"/>
    <dbReference type="eggNOG" id="arCOG04095">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_3_0_2"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019971">
        <property type="entry name" value="Ribosomal_L14P_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03673">
        <property type="entry name" value="uL14_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="138" mass="15096" checksum="398525CD5342DEF2" modified="2012-06-13" version="1">MAKRTGTAFSRRKTTYGVQVGTRVVVSDNSGAREAMIIGVPGYRGRLRRIPKAGIGDKVIVSVKKGIPEIRKQVLPAVVIRQRRPYRRSDGTWVAFEDNAVVIITPEGTLKGSEIRGPVAKEAAERWPSLANMASIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0J9</accession>
    <name>I0A0J9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">30S ribosomal protein S19P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rps19p</name>
        <name evidence="7" type="ordered locus">FFONT_0516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0516"/>
    <dbReference type="EnsemblBacteria" id="AFH42506">
        <property type="protein sequence ID" value="AFH42506"/>
        <property type="gene ID" value="FFONT_0516"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0516"/>
    <dbReference type="eggNOG" id="arCOG04099">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097347_1_0_2"/>
    <dbReference type="OMA" id="VIRTHCR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_S19A/S15e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="138" mass="15978" checksum="857BAEEB3209D48F" modified="2012-06-13" version="1">MSKPEIESEWKNFRYRGIKFDKLIEISMDELVSLFPARERRSITRGFTPEQIRFLQKIRRGKKEGKKVIKTHLRNMIVLPEMIGLTIAVYNGKEFIPVRITPEMLGKRLGEFAPTTKSVKHGEPGLKATRSSMFTAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0L3</accession>
    <name>I0A0L3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0530"/>
    <dbReference type="EnsemblBacteria" id="AFH42520">
        <property type="protein sequence ID" value="AFH42520"/>
        <property type="gene ID" value="FFONT_0530"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0530"/>
    <dbReference type="eggNOG" id="arCOG00894">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_3_2"/>
    <dbReference type="OMA" id="MGTYNEE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="313" mass="35420" checksum="6547CD151CAAEF31" modified="2012-06-13" version="1">MALELDGMEEAEQYKNLTVVIPVLNEEEAIGKVLEEVINQAKVPKDKILIVDGKSTDKTVEIAKSYGVKVIEQEGIGKSMAIKTALNYVGTEYILIMDGDYTYPAKYIVDLYREIKKEKDIVIGSRKKLEKGAQGLIYKIGNFGLTLTFNILFGTRISDVLSGMYVVRTDILREISFNSKNFGIESEILAHVVSEGGYAGEIQIEYRKRIGKKKLGVLHGFHIFVDMIKLMLNYNPTFFIFILGSLLLIPGLALGLYVAYYYFFTDITYYVKGLVAIMLTLAGFQSLLLAVLTLFIKRMEIRFLRLIRKSRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0M7</accession>
    <name>I0A0M7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Malate dehydrogenase (Oxaloacetate-decarboxylating)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0544</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0544"/>
    <dbReference type="EnsemblBacteria" id="AFH42534">
        <property type="protein sequence ID" value="AFH42534"/>
        <property type="gene ID" value="FFONT_0544"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0544"/>
    <dbReference type="eggNOG" id="arCOG00853">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034446_2_1_2"/>
    <dbReference type="OMA" id="HKYAAVV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="malic" evidence="4">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="3">
        <location>
            <begin position="166"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="441" mass="48936" checksum="4C1CDF772C4927AF" modified="2012-06-13" version="1">MSRGEKKDWASISEKLHKSYRGKIEVLPKVPITSLDDFSIWYTPGVAEPCKRINKDEDLSYEYTLRWNYAAVISDGTRVLGLGNIGPSAGLPVMEGKSLLFKYLGGVDAIPLVLGERDPEKFIAVVKALEPTFGAINLEDIESPKCFYILERLQEILNIPVWHDDQQGTALVILSALINALKLTGRRIKDTKIVLVGIGAANMATYRYLKVAGANPKNIIAVDKNGIVHPERDDIKREKDRNPWLFKVAEETSPEIRGGIPEAMNGADVVIAASAPGPGTIKKEWVSKMNKDAIVFAEANPIPEIWPWEAKETGAKIVATGRSDFPNQVNNSLGFPAVFRGVLSVGAKKMNDDMFLAAAYAIADYTEKTGLSKDRIIASMDEMELYVQEALAVALKAIDLGLARRKISKNELEREIREMIERPKKYMNIAIKNGIIEDRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0P7</accession>
    <name>I0A0P7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="6">ATase</shortName>
            <ecNumber evidence="6">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="6">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">purF</name>
        <name evidence="12" type="ordered locus">FFONT_0564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6 9">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6 10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0564"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="AFH42554">
        <property type="protein sequence ID" value="AFH42554"/>
        <property type="gene ID" value="FFONT_0564"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0564"/>
    <dbReference type="eggNOG" id="arCOG00093">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_3_2"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6 7 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="6 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="4"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6 8">
        <location>
            <position position="4"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 10">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH42554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="476" mass="53441" checksum="C6C79C650D21239F" modified="2012-06-13" version="1">MLMCGISAFLDEATFKEAIEEIAMMLYSLQHRGQEAFGISVLSKDRKFLVMRSRHQLFSLFLKSWKKELIEKKVIGGIGHVRYSTTGSYSAPSQPVLLESNDIKFSLAFNGTIANYKELDSKLARRKGEYRISPKIKNNDSITLANVLYSLYIDNEKDIVEALRYLPNYVIGGYSIVVETNEPRIVIAKDPYGFRPLSYSYESGFYAASENPALELIGKKSWKEVLPGEIVSYDGGKLERIYSERKVEPSPCLFEYVYFSRSDSVFNGISIYDARINMGRYLAEYAPVDGDVVIPVPDSGRVIALGYSKASGIPIEEGIVVNKYLGRGFITPPFQRPLVTKIKYNIVEEAVRGKEVVLIDDSIVRGTTMSDLVPKLKLKGAKKVHIRIGSPPYKCPCYMGIDVPTKSEVIAKNDEKVIAKMIGADSLIYNSLDNLIKAVPLRNLCHACFSCKYPFSEKSSCEYIKMLIDRGGRNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0P9</accession>
    <name>I0A0P9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">IMP biosynthesis enzyme PurP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0566</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="369" mass="42383" checksum="F321221872AC7AA4" modified="2012-06-13" version="1">MGRISSYEIERIIKNSGKISVSAVASHSALDVFDGAHDEGFKTIAICQKGREKTYERFISVISEVIILEKFSDIVKKEHQKKLQEKNSIFVPNRSFSVYVGYDKIEEEFEIPIFGNRFMLRYEERTGEKNYYKLLDKAGIRRPKTFANPDEIDRPVIVKMLHAVKKVERGFFIAIDREDFYRKFNRLVNDGIVNKEDINHASIEELVIGSHFNVNYFNSIAFNRNEIISIDRRIQTDLDGFLRLPADIQLDLKEFIDVEMIEIGHEPVTIRESMLEKLFEIGDKFVEASREIESPGIIGPYTLQLIVTKNLEPIVFDVATRIGGGTNAYMGIGSQYSKLYFGKPISLGRRISIELKECLTKGCLEEILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022691"/>
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    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <sequence length="177" mass="20458" checksum="CCFD4D1635C0614C" modified="2012-06-13" version="1">MHSNKKRLEENLLLELAQLSNEDVILDIGSGDGYYSFIFSKHAKKVYAIDKAYMDESLMNSLIQEGKEKGISNLEFLAKDVCEGLEIKYFNLAFFSNSFHDINCKKELLSYLYKNSAENGRLLIIEFKPSDSWLFGPPPHIRIKPEDLVKMATEVGFKLDKMIERDSQYIAIFKKEK</sequence>
</entry>
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    <accession>I0A0X2</accession>
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                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_0639"/>
    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="AFH42629.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="52" mass="6149" checksum="4A43FA9CCCB439FF" modified="2012-06-13" version="1">MGIRGVNMGFKSRQNMNDFYLPGYRIRGIRNEQLLALHYLKQSLNIIKSFVF</sequence>
</entry>
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    <accession>I0A103</accession>
    <name>I0A103_FERFK</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="90" mass="10103" checksum="107ECBB1F6E67752" modified="2012-06-13" version="1">MLPVVAGRNATGNASGTVVLAMIIIVTSMWMVGILKFWTLIILFAYMTYMLFLQFKYMRSGERAIAKRIFRGYTAFLGIAMVLMLLSALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A121</accession>
    <name>I0A121_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0690</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="MJ0683-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43432">
        <property type="entry name" value="PTHR43432"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Elp3"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="19"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="304" mass="34602" checksum="7CA590E44C0AF189" modified="2012-06-13" version="1">MERSIYPFSIFDPWQSSLCTCPKKYSLNPYTGCSFGCLYCYAKGYIGKRESTPKKDYVKLLERSARKLNRALPVNIGTSSDPYPDIEQKFKLTRASLSILINMNFKVLITTKGGELLLRDADLMKKGKVAVTPTVTTLNEDLAKKLEPMAPSPKERIRVMEEMNKNDIPLGARVDPIIPGLNDDEKELKELVNALAEAGARLIITSTYKARFVDFKDMINVFPDMREKWKRLYFEEGERIGGYMYLSKSLRERLLKLVVDEAKKLGLEYATCREGLTSPEYFKARSCDGTHLTEMGKRSGSEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I0A167</accession>
    <name>I0A167_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">FFONT_0736</name>
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    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42724">
        <property type="protein sequence ID" value="AFH42724"/>
        <property type="gene ID" value="FFONT_0736"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0736"/>
    <dbReference type="eggNOG" id="arCOG03878">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163797_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="123" mass="14741" checksum="F8720180B7D22CF0" modified="2012-06-13" version="1">MRKMKLKEIYEDEEVVVEVGPHDDEIPELIMDLFKKKQRPLTWQQLREHFSAIIGEDRLRRALRQLVSEERLVQLNRTTYADPETLTPEIIEELENKRRISSTRARNYIYDAMKKKSINGEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1B2</accession>
    <name>I0A1B2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Threonine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0781"/>
    <dbReference type="EnsemblBacteria" id="AFH42769">
        <property type="protein sequence ID" value="AFH42769"/>
        <property type="gene ID" value="FFONT_0781"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0781"/>
    <dbReference type="eggNOG" id="arCOG01431">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_2"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="339"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="417" mass="45555" checksum="A160BB6171F093DF" modified="2012-06-13" version="1">MLWRDKVLGKLVDNVWENILEAEKVLSGVIHKTPVDYSATFSKMTGNKLYFKLENMQKTGSFKVRGAYYKIFKHKDEIKGKGVIAASSGNHAQGVAFASNSLGIKSTIVMPEITPAFKVNATRNYGAEVVLYGKVYDEAYKKSIEISQQTGSVFIHPFNDIEIMGGQGTIGLEIASQLSDIDMVLVPVGGGGLISGIGTAIKKLKPSTKVIAVEPKNAPKYYVSRKNGKIETIEPLPSLADGVVTKGVGDLTFEVMSEVVDDVVVVDENSIATAIYLMLERSKIMVEGAGALPLAAMLEGYYNNMNKKIALVVSGGNIDLTMLYRIIMKGLSSIGRIVVLKVLTKDQPGELAKILNVLYKYKCNIVEVKHDRFSLRSPVGFASVEVIFEVPDIAVVERLKKDLIEMGIEVENSEHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1B5</accession>
    <name>I0A1B5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Translin family, DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0784"/>
    <dbReference type="EnsemblBacteria" id="AFH42772">
        <property type="protein sequence ID" value="AFH42772"/>
        <property type="gene ID" value="FFONT_0784"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0784"/>
    <dbReference type="eggNOG" id="arCOG04318">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099315_0_0_2"/>
    <dbReference type="OMA" id="EKTHGDI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033956">
        <property type="entry name" value="Translin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="PTHR10741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741:SF2">
        <property type="entry name" value="PTHR10741:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="SSF74784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="208" mass="24517" checksum="8CCDDF8FE89FAA45" modified="2012-06-13" version="1">MKEKLKEIISEIRGYLDERDMEREKLIVISRDVIRLSGNAIVLIEKGDFKGAEENINKMKELVEVFLSELKNFPELYYSGIAYNMLTEYAEAILLFHIMNENNIISYKEMNISPVPYLLGLGDVIGEIRRVIIDMIRKEDFENAWKLFEIMEEVFFQLSNMDYPDALVPGLRHKVDTARRLIDDTKYFLIDMESRHFLKKSLSIHIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1B6</accession>
    <name>I0A1B6_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Metal-binding protein-like protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0785"/>
    <dbReference type="EnsemblBacteria" id="AFH42773">
        <property type="protein sequence ID" value="AFH42773"/>
        <property type="gene ID" value="FFONT_0785"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0785"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147304_3_0_2"/>
    <dbReference type="OMA" id="SCFKAIN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014925">
        <property type="entry name" value="CGGC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08821">
        <property type="entry name" value="CGGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01078">
        <property type="entry name" value="CGGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CGGC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="148" mass="16950" checksum="D264867A2A0058F7" modified="2012-06-13" version="1">MEEKVKIGIIICDRYKNCAGGKCFRALRERVGGFSIYKDKEVEVVGYTTCGGCPGGNIEYAPEEMKKNGATVIHFATGMVVGYPPCPYIQYFKKYIEEKYNMKVVIGTHPIPEKYYTVHQKLGSWNSPEWQEMIKLVVTDEKTRRAYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1C9</accession>
    <name>I0A1C9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane-bound metal dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0798"/>
    <dbReference type="EnsemblBacteria" id="AFH42786">
        <property type="protein sequence ID" value="AFH42786"/>
        <property type="gene ID" value="FFONT_0798"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0798"/>
    <dbReference type="eggNOG" id="arCOG01744">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097802_3_2_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007404">
        <property type="entry name" value="YdjM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04307">
        <property type="entry name" value="YdjM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="149" mass="16912" checksum="B1A88E58B12EC866" modified="2012-06-13" version="1">MQKKTHLLFGTGLSLYIISLFGQISQISILFIVIFSIFPDLDLKNNHRKLFHNIFALLLIPAIAVVLSYNYLIDYQLTSESEILIYLSAVISYGLHLILDMLTKMGVYLFWPLSNKSIGLKLVRTDNNLLNAVLSIIGMLLIIKVFIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1E3</accession>
    <name>I0A1E3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0812"/>
    <dbReference type="EnsemblBacteria" id="AFH42800">
        <property type="protein sequence ID" value="AFH42800"/>
        <property type="gene ID" value="FFONT_0812"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0812"/>
    <dbReference type="eggNOG" id="arCOG00040">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080904_0_0_2"/>
    <dbReference type="OMA" id="MPVMLAP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="2">
        <location>
            <begin position="13"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="212" mass="24233" checksum="16364AC855C9DD6A" modified="2012-06-13" version="1">MSADNKFLTLKWEDIENAVAAISEKIIESNFNPNVVVGILRGGWIPARIFADFLGIKDIGAIEIKFYKGIEEKMERPVITQPLVLDIRNKNVLLVDDVADSGKSLQTALSAINFYGPKNLKTVSLYVKPWSVIIPDYYYGETDKWIVFPWEKRETIEALVQAEYKIISRATIDVEKISKEFSDKLGLSYEEVKRIITLIISERSFFNPETIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1E5</accession>
    <name>I0A1E5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S17e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps17e</name>
        <name evidence="5" type="ordered locus">FFONT_0814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0814"/>
    <dbReference type="EnsemblBacteria" id="AFH42802">
        <property type="protein sequence ID" value="AFH42802"/>
        <property type="gene ID" value="FFONT_0814"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0814"/>
    <dbReference type="eggNOG" id="arCOG01885">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176720_2_0_2"/>
    <dbReference type="OMA" id="TRDFEHN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_S17e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="RPS17e-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="PTHR10732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="SSF116820"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="68" mass="7850" checksum="298B49C563338F91" modified="2012-06-13" version="1">MGKVRTAMVKRTARKLITAHPDLFTEDFEENKQLIRKLVDVNSKRVSNKIAGYITHLVKVTKQRGELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1G5</accession>
    <name>I0A1G5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Major facilitator superfamily MFS_1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0834"/>
    <dbReference type="EnsemblBacteria" id="AFH42822">
        <property type="protein sequence ID" value="AFH42822"/>
        <property type="gene ID" value="FFONT_0834"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0834"/>
    <dbReference type="eggNOG" id="arCOG00130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040020_2_0_2"/>
    <dbReference type="OMA" id="FGFHRMM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="363" mass="39589" checksum="6BAC7A344F35721E" modified="2012-06-13" version="1">MTYEGARSVGGAYLEVLKAPLIFAGMLSIGELLAYLFRAFSGILVTKYRSSSFLWFLTITGYVTNLAVIPLLAISGNWIIAFILYMLERIGKGLRGPSRDIILSELIKGLGSGKGFGIHEFLDQLGAVSGPLIVAYYLAGHGGFYYAYLFLAIPATIAIALVFSAMIQYPKIESVHTDKRISFRVPRGTFRFFLVSIFLISVSFTQWGIISYRITLEGIGAQYAAILYVLAMAADAAVAIPLGMLFDKYGVKTIYPIPIISIFSNILLLFENSLFLLFLGSILWGTVTGYYESVFRAAVAELAKEDVAGGFGVYSLVQGIAMGIGGIIIAVFYIVSKSALIDYIIALNLIAMLFFALSTKRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1H7</accession>
    <name>I0A1H7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0846"/>
    <dbReference type="EnsemblBacteria" id="AFH42834">
        <property type="protein sequence ID" value="AFH42834"/>
        <property type="gene ID" value="FFONT_0846"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0846"/>
    <dbReference type="eggNOG" id="arCOG00084">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121272_0_0_2"/>
    <dbReference type="OMA" id="MITHEPG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THUMP" evidence="1">
        <location>
            <begin position="28"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="178" mass="20636" checksum="AA83EEB8AAF80F77" modified="2012-06-13" version="1">MRREPFNLIITHYPGYDNFVVAREQIKNIIENIRIVDTSQSIILAIVDEPYATIEKIKSLELKETPILRIIPVDRVTDIFVDRVKEVIHELFNTKVKKEETFKIKLDGHLYKRQEGSIEKIHKDEAIKILAEGLENPVNLKSPSWLVYVKTLRMYKATELASITVTKPENIISLAPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1K1</accession>
    <name>I0A1K1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ATP-NAD/AcoX kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0870"/>
    <dbReference type="EnsemblBacteria" id="AFH42858">
        <property type="protein sequence ID" value="AFH42858"/>
        <property type="gene ID" value="FFONT_0870"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0870"/>
    <dbReference type="eggNOG" id="arCOG01350">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064691_0_0_2"/>
    <dbReference type="OMA" id="RGNQQFS"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039065">
        <property type="entry name" value="AcoX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40697">
        <property type="entry name" value="PTHR40697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="378" mass="41600" checksum="6131DD5799503509" modified="2012-06-13" version="1">MKLTKIGFLANPIAGLGGALALKGSDDISWNDLGSLIGPGYKKALLFALILKERLKEKIEKVEFLVPDGMMGEDIFKRFGLSYTSVCSPNYPSTNLDTKNCAMEIKKEGAEVFFISGGDGTVYDVYTQVKTSIPIVGIPSGTKMYSSIFAKSINAAAILLEDFINENYVLEAGEILLVDENTIRENGSYRELFRGIAYTIESKNNLLHQQTKDLSYSEEESLEEIAEYVNEIVNDKVPLIIGPGRTCSKIAQKLNIKKDNVLSVAAGYKGKTYCSDCNSLQLSNFVDSLDNLDLLRIIVSPLGNSGYLFGRGNHQITGYILSKITIKNLLIVGSRNKMSRLKSLLIDIPKSNKLLTLSGYTRAIVGYEEEVVIKVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1K2</accession>
    <name>I0A1K2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="57" mass="6681" checksum="FD8778F0C8A96C9E" modified="2012-06-13" version="1">MFLLIRVIKMKKEKAIIEKWGKILYIKTETGKEALVPEEDLCNLIERFNLEVDGVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1N1</accession>
    <name>I0A1N1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Triosephosphate isomerase</fullName>
            <shortName evidence="2">TIM</shortName>
            <shortName evidence="2">TPI</shortName>
            <ecNumber evidence="2 3">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpiA</name>
        <name evidence="4" type="ordered locus">FFONT_0900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="2 3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0900"/>
    <dbReference type="EnsemblBacteria" id="AFH42888">
        <property type="protein sequence ID" value="AFH42888"/>
        <property type="gene ID" value="FFONT_0900"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0900"/>
    <dbReference type="eggNOG" id="arCOG01087">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104921_0_0_2"/>
    <dbReference type="OMA" id="IPVYAQH"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_A">
        <property type="entry name" value="TIM_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022891">
        <property type="entry name" value="Triosephosphate_isomerase_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="2 3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="1 2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="231" mass="24961" checksum="54B33C941335CEC6" modified="2012-06-13" version="1">MLPANKPIFVINYKAYETSYGHQALLIAKASEKAELEFSIKTIIAVPFTEIWRISKEVSIDVIAQHVDPIIPGQGTGFITAEMIAGSGGKGSILNHSEHKLKIFEIEKGIERLKLNNLYSIVCAETPRSSLAVANLGADIVAMEPPDLIGTGVSVSKSKPELVTKTVEKIRNSGFKKIPILVGAGIVDKEDARKAIKLGADGILVSSIIMKSKEPEKKIFELAEGLNSLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1N6</accession>
    <name>I0A1N6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exopeptidase, family M55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0905"/>
    <dbReference type="EnsemblBacteria" id="AFH42893">
        <property type="protein sequence ID" value="AFH42893"/>
        <property type="gene ID" value="FFONT_0905"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0905"/>
    <dbReference type="eggNOG" id="arCOG04080">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086038_1_0_2"/>
    <dbReference type="OMA" id="ATGVTWP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027476">
        <property type="entry name" value="DppA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007035">
        <property type="entry name" value="Peptidase_M55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036177">
        <property type="entry name" value="Peptidase_M55_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04951">
        <property type="entry name" value="Peptidase_M55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015853">
        <property type="entry name" value="Pep_DppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63992">
        <property type="entry name" value="SSF63992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="280" mass="30922" checksum="7D11E26BB7F68385" modified="2012-06-13" version="1">MKKAFLSVDLEGLPFIVNRGQLSTGNPLWEEGRRIASELTYAAVKAIHDEGFDEVIVADSHADMINIYYERLPKYAYLVRGYPRPRSMITGAEGCSAAFFLGYHAGVGTKDATYDHSFSSATIKELRLNSEKTSEFIFNTLALGEIGIPVIFVAGDEALREDVEKFAPWAVFVPLKKSYGRYSSISPSIEKLNEDLAQGVKEAVRRMSNGEANVASIDKPVNVKIDFLYSGYAEVAEYLPFVKRVSATAIEYISNSVLEAYNIMELLTIVASAVKVMTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1P3</accession>
    <name>I0A1P3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0912"/>
    <dbReference type="EnsemblBacteria" id="AFH42900">
        <property type="protein sequence ID" value="AFH42900"/>
        <property type="gene ID" value="FFONT_0912"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0912"/>
    <dbReference type="eggNOG" id="arCOG00169">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_951906_0_0_2"/>
    <dbReference type="OMA" id="LRWHPGY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="47"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="241" mass="26826" checksum="8260445C8D35C160" modified="2012-06-13" version="1">MGWIYLIIFLFILWIALERTYPYAIPSLSSVALYIEIQGIISIARNVFKTLENTFLGFALSFALAMISLIAYHINLHLRSFITALNTFIQSISVLVWSIIFVIIYGVTSGLPPIFVVSATSYPILLSIGISGMQSIEGKYRELFKVFGAKKRHELLYLIIPGTLPYLIGGSRAAIGSALRITVVAEALGASGGIGYMLLYSYDLGYKQGVFAWSILLVLLMILLDEAVLKPIEGWSRRWMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Q9</accession>
    <name>I0A1Q9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal flagellar protein FlaH</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0928"/>
    <dbReference type="EnsemblBacteria" id="AFH42916">
        <property type="protein sequence ID" value="AFH42916"/>
        <property type="gene ID" value="FFONT_0928"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0928"/>
    <dbReference type="eggNOG" id="arCOG04148">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094838_1_0_2"/>
    <dbReference type="OMA" id="IVKYNNA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014774">
        <property type="entry name" value="KaiC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06745">
        <property type="entry name" value="ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0966">Cell projection</keyword>
    <keyword evidence="2" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="234" mass="25862" checksum="2BA4A8D0313A429E" modified="2012-06-13" version="1">MKTTVSTGNDELDVRLQGGLPYPSLILIEGEQGTSKTVLAQQFVYGALRDGLRGIVLETEMPSVDFLRKMKLLKMDIVDYVIKGKVRLHSILSKNLEINDVVLSNALTVFEKYINSKLDNFDFLAIDSLSMLVKFAKYSEVLEFFSNLKKISTSGKLIFATMHSSILSEDILTKLRAFCDGYIKLGISNIGGRSVKVMNIVKLRGAPTSFDSVISFDVDPAFGIKLVPIALARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1T9</accession>
    <name>I0A1T9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0958</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional regulator.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="1">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0958"/>
    <dbReference type="EnsemblBacteria" id="AFH42946">
        <property type="protein sequence ID" value="AFH42946"/>
        <property type="gene ID" value="FFONT_0958"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0958"/>
    <dbReference type="eggNOG" id="arCOG01008">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113319_1_2_2"/>
    <dbReference type="OMA" id="AHNCLET"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010045">
        <property type="term" value="P:response to nickel cation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00476">
        <property type="entry name" value="NikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022988">
        <property type="entry name" value="Ni_resp_reg_NikR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0533">Nickel</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NikR_C" evidence="2">
        <location>
            <begin position="58"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="138" mass="15692" checksum="7F99CD49342A0308" modified="2012-06-13" version="1">MARLLVVKFGVSFPYELYKELEEVSKELGINSRSKALQNAASEFVARNRWLLSKGSVAGAIIMLYNHETGRLEEKITDIQHEYMDVIVSALHVHVSKEECLLIIAIKGEVSRIKRLYQSLSGLHGVMQIQYSIVPYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1V0</accession>
    <name>I0A1V0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42957">
        <property type="protein sequence ID" value="AFH42957"/>
        <property type="gene ID" value="FFONT_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0969"/>
    <dbReference type="eggNOG" id="arCOG10276">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059141_0_0_2"/>
    <dbReference type="OMA" id="IAYMFHA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="389" mass="42554" checksum="9EA735DFA0E54614" modified="2012-06-13" version="1">MWFFIAILFLSLLSFLDLGIFTYIGYSFNVSPLVYGIIAATWSLIYIISNKLFGNLADKGENKLLMLISLINIFVATFLFSRGSLAYIAIAYMFHAISVSTANLSVSSSIFELTDSESWWKYSAAQRLLVYLIRGTTLLLISTGILSLSIFQVLMIATAIAAISAIVLPSIGVNIERKLHLINKNVSNVIEYSNMKSLAAINLENPTGLQGVLEGFKLKEGGVSSKNILLSLFFAIAMGDFMFTIMPLLIKGDISLNTLWISHGITGIVIGISLVLMSKILKGSKKSATFFVLLRGLWLALGIPLLFKPSGLILYLIIMYLSSSAIDTIFYNLYSETNSGYGANNYFIVREMGTLFGSLIAGMIMTFGLTAIIISLALMCTIALISIDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Y3</accession>
    <name>I0A1Y3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1002"/>
    <dbReference type="EnsemblBacteria" id="AFH42990">
        <property type="protein sequence ID" value="AFH42990"/>
        <property type="gene ID" value="FFONT_1002"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1002"/>
    <dbReference type="eggNOG" id="arCOG00175">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="43"/>
            <end position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="349" mass="38557" checksum="9BD9F77EBFE3DBB7" modified="2012-06-13" version="1">MEGGIRLSDNSLDVIGLEAYLGGFHLGPINLNLKKNGVGLIIGPNGAGKSTLLKVILGLIDAKRGNIILNGREITKLPTEKRNIGYVPQSYALFENMTVRENIEFGLKVRKIPLNERNERVLNLARELKIEDLLNKKVSILSGGQKQRVALARALAILPDLLLLDEPFSNLDPQSFVNAIDLLDRTVARIGLSTIIVSQNASNLLKIATDVFFMKNGKMLYLGDPDKALRDPKVLEAAIYLGFDNFIKLSDVKKHANIFSDIQEKDGYLALRSNDISIVESEDNCEGFLIKGKLIKIYPEVNGSLYGELEIEEGTIIKARIQGKTSIKDSLDICINKNKASLILENFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Y6</accession>
    <name>I0A1Y6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein pelota homolog</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pelA</name>
        <name evidence="11" type="ordered locus">FFONT_1005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1005"/>
    <dbReference type="EnsemblBacteria" id="AFH42993">
        <property type="protein sequence ID" value="AFH42993"/>
        <property type="gene ID" value="FFONT_1005"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1005"/>
    <dbReference type="eggNOG" id="arCOG01741">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023334_0_0_2"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01853">
        <property type="entry name" value="PelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_1_Pelota"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023521">
        <property type="entry name" value="Pelota_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="Transl-rel_pelota"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PTHR10853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="SSF159065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1_1" evidence="10">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="373" mass="41745" checksum="5A9F69DA1814E43F" modified="2012-06-13" version="1">MKYEFIDNKKTVLKIKIENIDDLWLLYTILQKGDLITMKTLRDVKQSEGGKSRRLPMTLTISLSHMEFQPFTNKLRIRGIVKEGPDKFGILGSHHTLSVGEGDELIVFREEGWDQSTIKRMEKYKKSFGSVLIVAVDYDEYSIALFRRQGYKILVSNDLHIPGKGDESREKAITEAINEIASLVLSIINREKDIFGIVISGPGFFKEVVSEAIKNSINKLTIVLENTSMGGVYGIKETIAKGKPTEILKDEELKKSLQLLENILIKLSVKPEQVAIGLEECKNASEIGAVSDILILDELLSNQDLERRKEIEEVLNNVESFGGRVVILPSCSEASEKLYGLGSIVCLLRFPISTNKADFSSSTKNEGLSSSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Z9</accession>
    <name>I0A1Z9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sulfhydrogenase subunit delta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1018"/>
    <dbReference type="EnsemblBacteria" id="AFH43006">
        <property type="protein sequence ID" value="AFH43006"/>
        <property type="gene ID" value="FFONT_1018"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG02472">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_053270_0_0_2"/>
    <dbReference type="OMA" id="CKLNEYE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="2">
        <location>
            <begin position="14"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="260" mass="29019" checksum="E76CE1E3A1B61B4A" modified="2012-06-13" version="1">MNKLRIGVEKFASCSGCINEIVYALLSDPQIMEKIQIDYFPELQDKNNFEGKFDIFLVEGSVVNKEQIERLREIRSKTRFVLAVGTCSAYGGIQSLRDRTNVEDVKKSVYIKPEYIDIEGDVYSVSEIIKPDFIVPGCPVNGDKLLTLLRKVVLGGGEITITESLCAECKRRGNECILITKGKLCLGPIVSTGCGALCPSFGRGCIGCFGIRTDLSMNDIERFANKIEELGIASKEDVLSYVMRFSYSKDKEFFSKKQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A202</accession>
    <name>I0A202_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diphthine synthase</fullName>
            <ecNumber evidence="6">2.1.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Diphthamide biosynthesis methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dphB</name>
        <name evidence="9" type="ordered locus">FFONT_1021</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine-[translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36415"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="2.1.1.98"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.98" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1021"/>
    <dbReference type="EnsemblBacteria" id="AFH43009">
        <property type="protein sequence ID" value="AFH43009"/>
        <property type="gene ID" value="FFONT_1021"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1021"/>
    <dbReference type="eggNOG" id="arCOG04161">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066040_0_0_2"/>
    <dbReference type="OMA" id="TAGDPMV"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004164">
        <property type="term" value="F:diphthine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="PTHR10882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6 7">
        <location>
            <begin position="133"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 7">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH43009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="277" mass="31268" checksum="6E82045E8E20100B" modified="2012-06-13" version="1">MPIIMTNNEITNGKCLGELSFVGLGLSLSHISIEGIKKLKSSDFIFLEGYTSFYFPEINAAMKVIGIKSDRFKIISRRDIEEKSGQEIIDLLLKGKNISMAVIGDPFIATTHLSLKNYAKEKGCKVNYIPGINIFSYAMSATGLFNYKFGPSATIVYKREGILSVYPYLVLSGNLSRGLHTFFFLDIDAERGPLNASEAIKLLIEMEKEERLGIITPETKIVVLERLGWPDEKIYYGKISLLYNMRFNPPNSIIIPGKLHFMEEQSLEAFSIERNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A205</accession>
    <name>I0A205_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA synthetase (NDP forming), alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1024"/>
    <dbReference type="EnsemblBacteria" id="AFH43012">
        <property type="protein sequence ID" value="AFH43012"/>
        <property type="gene ID" value="FFONT_1024"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1024"/>
    <dbReference type="eggNOG" id="arCOG01340">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007415_2_3_2"/>
    <dbReference type="OMA" id="ICVVPTF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043758">
        <property type="term" value="F:acetate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043938">
        <property type="entry name" value="Ligase_CoA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19045">
        <property type="entry name" value="Ligase_CoA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="457" mass="49560" checksum="5043D94203F0A0E9" modified="2012-06-13" version="1">MNFDYRYFFEPKSIAVIGASNNETKLGHQVFKNLLSYKGKVFPVNVKEESIMGVKAYKTIKDIQDEIDLSVIVVPKPAVKQAVIESGEKGAKGIIIITAGFGETGERGKEEERELVRVAHDYGMRVIGPNCVGVMNTKIDLNATFIEKAKKGSVTFISQSGALGGGIVYKTIKENIGFAKFVSVGNMSDVDFSDLIEYFSRDPDTASILLYLEGVKSGKRFLEVLKEHSKEKPIIALKGGIYSTGARAVSSHTGSIAGNAEIFMTALKQGGAIKAKTIDEALSMARSFTQPLPKGKRVGVITNAGGAGVLISDLIEENGLEMSKLKDETISYLSSFLPPMASLKNPIDMIASATGNDYYRATKALLKDDDVDIIIESCVVPTFGGMTRTEHAEGIVKAINESEVKKPILAMFMAGDISEDAKRFLESNGIPTYERPEDVVSATRALYSFSLISSKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A217</accession>
    <name>I0A217_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1036"/>
    <dbReference type="EnsemblBacteria" id="AFH43024">
        <property type="protein sequence ID" value="AFH43024"/>
        <property type="gene ID" value="FFONT_1036"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1036"/>
    <dbReference type="HOGENOM" id="CLU_1801619_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="143" mass="16860" checksum="B84618FE0865A3A1" modified="2012-06-13" version="1">MRISNIMWGLSILFLAMFFIMSSNSPLYSEFVNIFGNSIKIYQSLFGFFSLILLLVAYYQNELESHPKKIAQLRFFNLVAYIAWLLSSLALYSLFLYRFGFPIGLVVSILILFPLFISILQYTKKMIKTIELHYEKNQKKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I0A219</accession>
    <name>I0A219_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="5">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glmS</name>
        <name evidence="8" type="ordered locus">FFONT_1038</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1038"/>
    <dbReference type="EnsemblBacteria" id="AFH43026">
        <property type="protein sequence ID" value="AFH43026"/>
        <property type="gene ID" value="FFONT_1038"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1038"/>
    <dbReference type="eggNOG" id="arCOG00057">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_7_0_2"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="6">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="304"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="477"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="5">
        <location>
            <position position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH43026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="626" mass="68964" checksum="05FE4B13F2AAA986" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A224</accession>
    <name>I0A224_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycosyltransferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_1043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1043"/>
    <dbReference type="EnsemblBacteria" id="AFH43031">
        <property type="protein sequence ID" value="AFH43031"/>
        <property type="gene ID" value="FFONT_1043"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1043"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_558540_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="73"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="3">
        <location>
            <begin position="182"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="488" mass="56273" checksum="DFFDE8218D412120" modified="2012-06-13" version="1">MYLDPSLITNYVDIQDLIQINMIILLIKYTFYTIWIVPAYRLAMTFKSWRKNFSFYSVQELAEEIKTIEGKISVLIPARNSENYIISSILSAFNQSVPPKSIYILNDNSTDNTIKKVMNFISQKNGKLKRVIYKDKYIFISYDVKRSDGIKVEINVVDFKEHMGKPSMINEVLPSLNDKVDYVLILDSDTIIERRYIEKMLVFLNRDSKLAGVNGTILLWKPEKEGRFSWFFAKAFRNLASLYYLLTLRFSETVFNSVNSLNGSCSIYKLKPLLEIGGIPTDTYVEDSSTSWHLQLLGYSVAYIPTAYSFTVDPSSPKRFFSKVLRITVGIQKLFLTRLPKLIKKKKYNLLLTSIYTSFGSLPFILMIANTINSIILASLGIYSSSILEKMYEIFQFTPISIILLAFLKYPIIYLILSYVTGVLEVVAAYYFLRIIYKDEKIIRNALDRSKSGLILVPLILWVQSFIALIAFPITVFQILAKKKLSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A241</accession>
    <name>I0A241_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="7">TC-AMP synthase</shortName>
            <ecNumber evidence="4 7">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FFONT_1060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + hydrogencarbonate + L-threonine = diphosphate + H2O + L-threonylcarbamoyladenylate</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the SUA5 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="4 7"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1060"/>
    <dbReference type="EnsemblBacteria" id="AFH43048">
        <property type="protein sequence ID" value="AFH43048"/>
        <property type="gene ID" value="FFONT_1060"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1060"/>
    <dbReference type="eggNOG" id="arCOG01952">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_0_0_2"/>
    <dbReference type="OMA" id="GMLKSHY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="9">
        <location>
            <begin position="14"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH43048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="355" mass="39262" checksum="D2C5ECE052928C45" modified="2012-06-13" version="1">MTIILKIDPSKIDAEKIKIASSIIKNGGLVAFPTETVYGLGANALNEHATRKIYQVKGRPSDNPIIVHISSIEMLEKIAVNVPEIAYKLIKKLWPGPLTLILKRSNAVPKLVTGGLDTVAVRMPAHPIAQNLIEQAELPIAAPSANISGKPSPTRAEHVIKDLYGKIEAIIDGGEVLYGVESTVINVLSEEPILLRPGAYSVEIIESIIDRKVKIPHFAKGIGEAEKAIAPGTRYRHYAPEAKLILIEPSTFTEDEIKKMISKIKDIANQYKNEVCIITSSENYYEYSRILDEKRLFVLGSRNNLFEIAKNVFDVLRKIDEYGCKVAISESFEERGLGLAVMNRLRKASSDIIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I0A267</accession>
    <name>I0A267_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1086"/>
    <dbReference type="EnsemblBacteria" id="AFH43074">
        <property type="protein sequence ID" value="AFH43074"/>
        <property type="gene ID" value="FFONT_1086"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1086"/>
    <dbReference type="eggNOG" id="arCOG03142">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1335012_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="205" mass="23490" checksum="F3CFF709BEA2C6A9" modified="2012-06-13" version="1">MLLLSIVSSKDYYLFVKNLREESIDFKSPSYLPFKCSEDDVVICDKKGCKEIIGTCRKFKIEKFTDEVFLSLIPFMIDGKEKYKEIIVGIDVGREIGYVVLADGKIIGKGKVIQDEIISVLKKYENVPHDNMIVKIGDYNDNNRLWNLTSTILENVSAELELVDEYKTSKIKRKQLEEKDPDVKAAYIIANRSGTIKLRKHGKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A270</accession>
    <name>I0A270_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Ribosome biogenesis protein Nop10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nop10</name>
        <name evidence="8" type="ordered locus">FFONT_1089</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NOP10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1089"/>
    <dbReference type="EnsemblBacteria" id="AFH43077">
        <property type="protein sequence ID" value="AFH43077"/>
        <property type="gene ID" value="FFONT_1089"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1089"/>
    <dbReference type="eggNOG" id="arCOG00906">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_196480_1_0_2"/>
    <dbReference type="OMA" id="FRIRKCP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00803">
        <property type="entry name" value="Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023532">
        <property type="entry name" value="Nop10_arc-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="SSF144210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 7" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH43077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="64" mass="7684" checksum="21FC8FB1AE4A0518" modified="2012-06-13" version="1">MMIKMKWLMRKCSKCKRYTLETGRCPYCGGELFVPHPHRFSPEDKYAKYRIAIKLTKERTLNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A290</accession>
    <name>I0A290_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit Rpo4</fullName>
            <ecNumber evidence="3">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA-directed RNA polymerase subunit F</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpo4</name>
        <name evidence="3" type="synonym">rpoF</name>
        <name evidence="4" type="ordered locus">FFONT_1109</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1109"/>
    <dbReference type="EnsemblBacteria" id="AFH43097">
        <property type="protein sequence ID" value="AFH43097"/>
        <property type="gene ID" value="FFONT_1109"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1109"/>
    <dbReference type="eggNOG" id="arCOG01016">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2190925_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00864">
        <property type="entry name" value="RNApol_arch_Rpo4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010924">
        <property type="entry name" value="Rpo4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="108" mass="12296" checksum="1573CE87845F5D19" modified="2012-06-13" version="1">MPRIIVSKEYLSNSQLEELLKSSSFDKDSIIIKKVEEYLSAVRKCKAENIKEILEELKKLSIPEELAVMIINVLPTESAELRALLPQQYQSLPSETVEKAVEIVSKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A291</accession>
    <name>I0A291_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1110"/>
    <dbReference type="EnsemblBacteria" id="AFH43098">
        <property type="protein sequence ID" value="AFH43098"/>
        <property type="gene ID" value="FFONT_1110"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1110"/>
    <dbReference type="eggNOG" id="arCOG04130">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076814_1_0_2"/>
    <dbReference type="OMA" id="IGKKLMW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007003">
        <property type="entry name" value="DUF655"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40734">
        <property type="entry name" value="PTHR40734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04919">
        <property type="entry name" value="DUF655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="227" mass="26371" checksum="8E5D5EA5549CDFA0" modified="2012-06-13" version="1">MSNEREGDRYFYGEAKKKREIPDDVAVVLDFLPHGNPFDKHVEHRRVPLAQVVGYKYFTLFELVVPEGENFEVGEKIYAGPDYVGKGPIKSIFGPISYEDLTTVAKENLVSVLSQIIKENEKYFLKFFNNAGSITLRMHMLELLPGIGKRTLNVMLDERKRKPFESFEDIVQRLTIRGVKIHNIEKVIAERIVKELIGGERYYLFIRPSPNESQAVYLRILDEIYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2A1</accession>
    <name>I0A2A1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uracil phosphoribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
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</entry>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
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    <sequence length="108" mass="12647" checksum="F7F26AA468FCF681" modified="2012-06-13" version="1">MKEVQELKKEKITTKYRKGEAFKIIVEPPQDEKTYILDVYLLKNLKGHISGRIKVINNNGDVVLECVYRKMKVRRVRGSSHLIWAVKKLLEKLKVPVKRYNVKTGEPI</sequence>
</entry>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        </location>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
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        <source>
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    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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        <location>
            <begin position="147"/>
            <end position="205"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <sequence length="329" mass="38663" checksum="87051CBA58ED6765" modified="2012-06-13" version="1">MKNESSWVNDYLQELLESTVKNIIKSGFEFVKIDRPDNFNERSIDILAWSKDEKKKKIHLKITLDTSFLSKEEIRDLIGITKSASSRPIIVSEYDKKIDIQDEVIYLKENVPTVNVTTLPKLLSCSKDLYIFLKKGEFVVRISGEKMRERREKLGLSLGELANRLGVTRKSIYEYEKNTFDVRIDYADKLFDTLGEEIVSPYNIFSDEVVEMVKMKKEEIPDNLFEEKIFNILNEKNMFFYHARKTFVDIIAKKGEEIFFIAIDHEHMPLTLEEKAEQLSKIKKLKDVEKMIVAKKEKAKELKKEYSDEIRIIPDDKINTISRILDERK</sequence>
</entry>
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    <accession>I0A2K2</accession>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <dbReference type="EMBL" id="AFH43209.1"/>
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    </evidence>
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    </evidence>
    <sequence length="188" mass="21409" checksum="6DEEECDE3233F41F" modified="2012-06-13" version="1">MKENRESVRIFLTGHPGIGKTTLVLKLASILTLEKVKFAGFATPEKRGKSGREGFELIIFPSNEVHELASKSIEKGYKMKLGSYYVNENMGAIILKIINEYLNDDSFKFFIGDEVGPMELMIPGIREGILKLLKAEEKSMLMSFHINLKQKDPEIYDLISKGDVYVLSTENRNQILNDIINKIRRKII</sequence>
</entry>
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    <accession>I0A2K8</accession>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    <sequence length="271" mass="31397" checksum="0231862F27F83211" modified="2012-06-13" version="1">MSEELKQKLAELVKKKIGQNSYERFSDIISEEINKALLNKKIAESLERKGKLDDASEVKKLIKKIKKRIYYSSRVFYSAEGEHVSILERGKNLTAILEFLKKLMIEKNINTIVDIGSGTFPIYFDAFLGEASPKLRYYAIEKNKKIYESLLIYSKKSKMLLTPILADADTDSLEEIYKNINNYDKSLTLLLRILHTLYRTKRLNLVEFVEKIGSKYLLISEPKFSLVKKNDISKKEKAFLLRLSNKLKANGTISDFEILDTEEEIFVLMTK</sequence>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
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            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
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            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
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        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH43220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_1232"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1232"/>
    <dbReference type="eggNOG" id="arCOG00809">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004174_0_0_2"/>
    <dbReference type="OMA" id="AWNMAFQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_A">
        <property type="entry name" value="Leu_tRNA_synth_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020791">
        <property type="entry name" value="Leu-tRNA-lgase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="PTHR45794"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="10">
        <location>
            <begin position="735"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="654"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH43220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="987" mass="114683" checksum="DDD387BE7F595C37" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2L4</accession>
    <name>I0A2L4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Diaminopimelate decarboxylase</fullName>
            <shortName evidence="2">DAP decarboxylase</shortName>
            <shortName evidence="2">DAPDC</shortName>
            <ecNumber evidence="2 3">4.1.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lysA</name>
        <name evidence="6" type="ordered locus">FFONT_1233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>H(+) + meso-2,6-diaminoheptanedioate = CO2 + L-lysine</text>
            <dbReference type="Rhea" id="RHEA:15101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="4.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 2 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.20" evidence="2 3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1233"/>
    <dbReference type="EnsemblBacteria" id="AFH43221">
        <property type="protein sequence ID" value="AFH43221"/>
        <property type="gene ID" value="FFONT_1233"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1233"/>
    <dbReference type="eggNOG" id="arCOG02268">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_2_2"/>
    <dbReference type="OMA" id="YCRSMAS"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02120">
        <property type="entry name" value="LysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01048">
        <property type="entry name" value="lysA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="4">
        <location>
            <begin position="241"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="233"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="378" mass="42153" checksum="0993BF2A33F9E193" modified="2012-06-13" version="1">MLLNNYERLKKSIKYRDLEVLYSCKANNNIDILKVLKEEGSGLDVVSPFEALLGVKLGFQKDKILFTGNNVSNEEMKFLKELGILINIDSISQLKRYGIMFPGTDISIRINPGIGYGHHEYAKTGGLTKFGIYLNEIEAAKEYVMKYNLRIRGIHIHIGSGILQTDPYISALNILLKIANEFKDLEFIDLGGGLGIPYRPGEEKFDLGDFGEKVSSILEDFSRKHGHVKLRIEPGRYIVGSCGVLLVRVVSIKDVSLNGKRKIFIGVDSGMNHLIRPSLYGSYHEIIDVTKASDEKEIVADIVGNICETGDFLALDRPMPKVEEGDVLAVMDAGAYGYSMSSNYNLRPRPAEIFVDGSTAKVSRRRETFEDLLSTFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2M1</accession>
    <name>I0A2M1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1240"/>
    <dbReference type="EnsemblBacteria" id="AFH43228">
        <property type="protein sequence ID" value="AFH43228"/>
        <property type="gene ID" value="FFONT_1240"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1240"/>
    <dbReference type="HOGENOM" id="CLU_2893082_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="62" mass="7249" checksum="8FEBF6DDFB457CE3" modified="2012-06-13" version="1">MEYIHDPEIRKVMNEIIASYKELAPVFKAVPPYDYPYAILLSGLIKALKRIDEIEQMVEHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2N6</accession>
    <name>I0A2N6_FERFK</name>
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        <recommendedName>
            <fullName evidence="3">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rps15</name>
        <name evidence="7" type="ordered locus">FFONT_1255</name>
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    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_1255"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S15P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="PTHR11885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal_S13_N" evidence="6">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH43243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="152" mass="17673" checksum="FE688E66D12AEC09" modified="2012-06-13" version="1">MNKKREKGKSHSTRPVSVGTPKWLRLEPEEIEELVVELAKKGYPPSMIGIILRDQYGIPLVKTVTNKKITQILKERGLLPQIPEDLYNLIRRAVNVRRHLSEHPKDENVKKGLQEIESKIRRLVRYYKRIGRLPPNWEYSPETAKLLASQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Q2</accession>
    <name>I0A2Q2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription elongation factor Spt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">spt5</name>
        <name evidence="6" type="ordered locus">FFONT_1271</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Stimulates transcription elongation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Spt5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1271"/>
    <dbReference type="EnsemblBacteria" id="AFH43259">
        <property type="protein sequence ID" value="AFH43259"/>
        <property type="gene ID" value="FFONT_1271"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1271"/>
    <dbReference type="eggNOG" id="arCOG01920">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113589_0_0_2"/>
    <dbReference type="OMA" id="FSEIEHF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
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    </dbReference>
    <dbReference type="HAMAP" id="MF_00950">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
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        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011590">
        <property type="entry name" value="Spt5_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00405">
        <property type="entry name" value="KOW_elon_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NGN" evidence="4">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="109"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="167" mass="18795" checksum="0A95424C19DA1081" modified="2012-06-13" version="1">MKKMENNEKINNGEKPAEKKSSFYLIRTVSRQELNVALLLERKIALSHSPIYSIILPPKLKGYLVLESQKSSAVEAVIKDMQHLRKRVYGTLTVEDVERMTKPKATIETLNPGDTVEVIAGPFQGIKAQVIEIDKVKQEVVLNILESAYPLKVTIPGEFVKPVKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Q3</accession>
    <name>I0A2Q3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl11</name>
        <name evidence="6" type="ordered locus">FFONT_1272</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1272"/>
    <dbReference type="EnsemblBacteria" id="AFH43260">
        <property type="protein sequence ID" value="AFH43260"/>
        <property type="gene ID" value="FFONT_1272"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1272"/>
    <dbReference type="eggNOG" id="arCOG04372">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_4_0_2"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_L11_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L11" evidence="5">
        <location>
            <begin position="68"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="167" mass="18824" checksum="3D3BD36C6A5A8EEE" modified="2012-06-13" version="1">MSEVKIINLSVKTGNVSQKDLEEAKKYGFNVDEIAEKINKRIGALKEKEVKITIYLYPSVKDYIIEVKPPTVTELLLWKAKAKEPSGDPAHKKVGDIKVADLAEVAIIMKNELLTRDLKKAVKMLLGSARSIGLTVEGKDPKDVQKELESGTYDKIIEDYIKDWEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Q6</accession>
    <name>I0A2Q6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl12</name>
        <name evidence="6" type="ordered locus">FFONT_1275</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1275"/>
    <dbReference type="EnsemblBacteria" id="AFH43263">
        <property type="protein sequence ID" value="AFH43263"/>
        <property type="gene ID" value="FFONT_1275"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1275"/>
    <dbReference type="eggNOG" id="arCOG04287">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114656_2_0_2"/>
    <dbReference type="OMA" id="EYIYAAM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05832">
        <property type="entry name" value="Ribosomal_L12p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_L12/P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022295">
        <property type="entry name" value="Ribosomal_L12_arc"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03685">
        <property type="entry name" value="ribo_P1_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="99" mass="10553" checksum="8FF53D4A437AE29C" modified="2012-06-13" version="1">MLHSAKKDINEENIKKVLESAGIQVDDVRVKALVAALQQINIDEVLKSALVTGAVAPAAPAAAPASEEKKEEKKEEKAEEEKKELSEEELSSGLGALFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2T2</accession>
    <name>I0A2T2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Reverse gyrase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="13">Helicase</fullName>
                <ecNumber evidence="13">3.6.4.12</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="13">Topoisomerase</fullName>
                <ecNumber evidence="13">5.6.2.2</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="primary">rgy</name>
        <name evidence="18" type="ordered locus">FFONT_1301</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="19" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13 14">Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1 13">Monomer.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="13"/>
    <dbReference type="EC" id="5.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1301"/>
    <dbReference type="EnsemblBacteria" id="AFH43289">
        <property type="protein sequence ID" value="AFH43289"/>
        <property type="gene ID" value="FFONT_1301"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1301"/>
    <dbReference type="eggNOG" id="arCOG01526">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002886_0_0_2"/>
    <dbReference type="OMA" id="GVATYYG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03361">
        <property type="entry name" value="TOPRIM_TopoIA_RevGyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01125">
        <property type="entry name" value="Reverse_gyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005736">
        <property type="entry name" value="Reverse_gyrase"/>
    </dbReference>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="8"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="211" mass="24323" checksum="E76A0A211B085310" modified="2012-06-13" version="1">MHLAYLMGFEISSFCSIAPKEEDSMLFHYPATRFLKVFEEAYGIPLLLLEGSGDEMEDLRNLLSECKSEGIEYVVSGALASDYQRIRYSIVAEELGLKTLNPLWRKDQKEYMKWLIEGGFEYIIVKISSFGLPFDLLGKTITYEDTLRIISLAEKYGFNPAFEGGEAETLVLDAPLMKKRLEVEGERRIEGNYVAYYDIRNIKLVEKRKIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ63</accession>
    <name>H9ZZ63_FERFK</name>
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        <submittedName>
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        </submittedName>
    </protein>
    <gene>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42020">
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        <property type="gene ID" value="FFONT_0024"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthami_syn_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="153" mass="17095" checksum="C436316B901072C6" modified="2012-06-13" version="1">MGKSPETILLTGRLVAAVKLNKGKEFEETADVLRKLGAEEIIAGDVYVEDHLKYMERLGEEVGAKLVESLWGIDPEELLHEEIASGIRTLVVGCEYSMSNWLGREISSESVENFLRDAKRGGSTTLSSSPDQCTEPRFHIQNPWLRITTVTKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ71</accession>
    <name>H9ZZ71_FERFK</name>
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        <recommendedName>
            <fullName evidence="2">UPF0235 protein FFONT_0032</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ordered locus">FFONT_0032</name>
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    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
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        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42028">
        <property type="protein sequence ID" value="AFH42028"/>
        <property type="gene ID" value="FFONT_0032"/>
    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="107" mass="11880" checksum="7B93D0C26B2EE132" modified="2012-06-13" version="1">MPGKNGVAKSSIQIGNGFVDLIIYVKPKSKDTGIISERGELIFHSTQPPERGKVNASLIKFLSKLTGISSNKIEINRGEKDRVKTVRIYCDDPEKIVGLFAEYLSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZ97</accession>
    <name>H9ZZ97_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ATP-dependent RNA helicase related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FFONT_0060</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0060"/>
    <dbReference type="EnsemblBacteria" id="AFH42054">
        <property type="protein sequence ID" value="AFH42054"/>
        <property type="gene ID" value="FFONT_0060"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0060"/>
    <dbReference type="eggNOG" id="arCOG01444">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_493152_0_0_2"/>
    <dbReference type="OMA" id="MLIHGRM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031:SF539">
        <property type="entry name" value="PTHR24031:SF539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="11"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="246"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.21" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0123"/>
    <dbReference type="EnsemblBacteria" id="AFH42115">
        <property type="protein sequence ID" value="AFH42115"/>
        <property type="gene ID" value="FFONT_0123"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0123"/>
    <dbReference type="eggNOG" id="arCOG02044">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_351153_0_0_2"/>
    <dbReference type="OMA" id="VAYSSWY"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004576">
        <property type="term" value="F:oligosaccharyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006486">
        <property type="term" value="P:protein glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="PTHR13872"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AFH42115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="755" mass="84416" checksum="E308574B5B19A0A7" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZM4</accession>
    <name>H9ZZM4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0190"/>
    <dbReference type="EnsemblBacteria" id="AFH42181">
        <property type="protein sequence ID" value="AFH42181"/>
        <property type="gene ID" value="FFONT_0190"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0190"/>
    <dbReference type="eggNOG" id="arCOG00555">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_312314_0_0_2"/>
    <dbReference type="OMA" id="IAFETIM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="65"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="333"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="1055" mass="121196" checksum="2079E6D423A8B62D" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZN7</accession>
    <name>H9ZZN7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="4">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pcm</name>
        <name evidence="5" type="ordered locus">FFONT_0203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0203"/>
    <dbReference type="EnsemblBacteria" id="AFH42194">
        <property type="protein sequence ID" value="AFH42194"/>
        <property type="gene ID" value="FFONT_0203"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0203"/>
    <dbReference type="eggNOG" id="arCOG00976">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_2"/>
    <dbReference type="OMA" id="TISAIHM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    <feature type="active site" evidence="4">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="229" mass="25545" checksum="CC69D9AB35520924" modified="2012-06-13" version="1">MIRGKRMKEKEWVIKNLESEGFRIPEKVRRAFLKVDRKLFVPQQYEDMANADTPLPIGYGQTISAMHMVLIMTTLLDPEVGDKVLEVGTGSGYQAAILAEIVAPSNTEIKKSGHVYTVERIKELAEFAKENLKKAGYCDRVTVFVGDGSQGLKEFSPYDRIIVTAASPKVPESLKDQLKVGGTLVIPIGSIEFQSLYVIRKNSEKTFNIKKSISCVFVPLIGKEGFDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZV7</accession>
    <name>H9ZZV7_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Nucleotide-binding protein, mrp/nbp35 family</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">FFONT_0274</name>
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    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_0274"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000007391">
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    </dbReference>
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        <property type="term" value="F:iron-sulfur cluster binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016226">
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    </dbReference>
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        <property type="entry name" value="NUBPL-like"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="YlxH/NBP35"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="254" mass="28384" checksum="572844B4451FF644" modified="2012-06-13" version="1">MSQKLIDPRIFGIRTKTANVKNIIGIVSSKGGVGKTTISTLLAIALNELGLKTGLLDLDLTNPNTHLILGADMKINFEEENGIKPVIINEIKYFSPVILTEGRISPLRGREIDSALKELLSILDWGSLDFLIIDTPPGMSDELYDLIELLPQIKLILVSSPDKLSLESIKNMIKNLEKENAKILGIVVNLYRTTFDAYKNHKELLNKGLKMLKLISYDDTFIFSLGSIDKVKNTTVFKEVYDIALEILKEARKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZX0</accession>
    <name>H9ZZX0_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42277">
        <property type="protein sequence ID" value="AFH42277"/>
        <property type="gene ID" value="FFONT_0287"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0287"/>
    <dbReference type="HOGENOM" id="CLU_3322797_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="38" mass="4463" checksum="D5D820FEACF56752" modified="2012-06-13" version="1">MLVRIYITIFLLLFAFLFVSNSKNRAYIGSNIILKIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZX4</accession>
    <name>H9ZZX4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0291"/>
    <dbReference type="EnsemblBacteria" id="AFH42281">
        <property type="protein sequence ID" value="AFH42281"/>
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    </dbReference>
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    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
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        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="44"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="187" mass="22208" checksum="4B3F2080A723269B" modified="2012-06-13" version="1">MEEKISIMQKYNITYDTYEMLYKIEQEEKYKLIDKLIDQIRGKILDAGIGTGLFEEYLFRNGKMINFDLIVGIDISIKMLDELIKKRDFLKEKIELVNGDIAFAPFREKIFDYTFSFTSLFLNNDYENELNELERVTKKSIVLSILKKGLKEKMLEILQHHNATMITQNDKDAVYLIKLKNHYQNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZZ0</accession>
    <name>H9ZZZ0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type-4 uracil-DNA glycosylase</fullName>
            <ecNumber evidence="3">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FFONT_0307</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0307"/>
    <dbReference type="EnsemblBacteria" id="AFH42297">
        <property type="protein sequence ID" value="AFH42297"/>
        <property type="gene ID" value="FFONT_0307"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0307"/>
    <dbReference type="eggNOG" id="arCOG00905">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044815_1_3_2"/>
    <dbReference type="OMA" id="NCRGYLE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005273">
        <property type="entry name" value="Ura-DNA_glyco_family4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00758">
        <property type="entry name" value="UDG_fam4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDG" evidence="9">
        <location>
            <begin position="31"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="195" mass="22710" checksum="78EB272D4F97D861" modified="2012-06-13" version="1">MMSFISYDEFIKQIENCKKCELYLSRTKPVVGEGNLNSKFVLIGEAPGKNEDIYGRPFVGRAGEVLNRALDEIKVDRINVYITNVVKCRPPKNRKPKTNEVLSCLHYLIFQLMYINPLKIVLLGGTAVKYLYDESFPYKKIPKEKKISEIRGKLGNFKAYDRSFQTYATYHPAMILRNPRLYEVFKEDLDMYLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A007</accession>
    <name>I0A007_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="7">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisS</name>
        <name evidence="9" type="ordered locus">FFONT_0324</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="7"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0324"/>
    <dbReference type="EnsemblBacteria" id="AFH42314">
        <property type="protein sequence ID" value="AFH42314"/>
        <property type="gene ID" value="FFONT_0324"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0324"/>
    <dbReference type="eggNOG" id="arCOG00404">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_3_0_2"/>
    <dbReference type="OMA" id="CDFDFIG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="434" mass="50646" checksum="765952FB082D9A82" modified="2012-06-13" version="1">MSSKPEVPRGFRDFPPEVMELRLKVINTVRNIFEINDFPPMDTPSIEYWETLAGKYGPEAENKLIWRFKDPFSEKEYALRYDLTVPLARYVASHPELQLPFKRHQISYVWRHEEPQRGRYREFLQADIDTVGSKFVESDAEIINTMSLVLEELGLDDFIVKINHRKILYIIFEKRLGSNVTSVLRAIDKLDKIGIDGVILELQKIGLDESSINWIINLISNRDSIDNLENIKKNLVEFDFSLEDPLNELIEFREFLAHRKHIVFDLSLVRGLDYYTGIIFEISLEKGSPGSIAGGGRYDNLIKMFKGSDLPATGGSLGIERIFDVLEERNITSKFKKKNKVFIITLNEDSYKYAWNFSYELRTRGIKTEIDLMRRNVDKQKKKGASENILFHVYIGKKEKEGRYITIVERDTGKRLELPYDKAIDYILIQLKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I0A023</accession>
    <name>I0A023_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Pyruvate kinase</fullName>
            <ecNumber evidence="3 11">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">FFONT_0340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="3 11"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0340"/>
    <dbReference type="EnsemblBacteria" id="AFH42330">
        <property type="protein sequence ID" value="AFH42330"/>
        <property type="gene ID" value="FFONT_0340"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0340"/>
    <dbReference type="eggNOG" id="arCOG04120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_1_1_2"/>
    <dbReference type="OMA" id="QVPIVQK"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="12">
        <location>
            <begin position="3"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="13">
        <location>
            <begin position="361"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AFH42330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="461" mass="51586" checksum="6C0446E1F2C453EC" modified="2012-06-13" version="1">MENKTKIIVTMGPSIEKYEVLLSLVKEGARGFRINFSHGDPSQWYNYINNLKSVEKELSIPLGIIGDLQGPNIRIGQLINQINLKKDDIVQFFYGNKSETNDIPLPYEEFFKTVERGDVIQLADGAIQLIVLETSPKSFIAKTIAGGVITSRKSISIKDKDIEIPYVTEKDERDIEFACNNDFSHLMASFVESKDNIFQLKELLNKKCNKQLNILAKIETKRGVYNVEEILKVADGIVVARGDLGTHFPMETLPTIQKDLISKSIVQGKPSIVATQLLSSMLNSPIPTRSEIVDIYNAVQESANALMLTNETSIGNYPIDAVRWLKKVIIEAEKNSAIVYPVKPIENSLAHRFALGISEFSRQLNAKISVYTKSGLTAQNISLYRPYGIIYAGVPDMHTARKLSIIWGVEPYVLAADSYENGLEKIRKVLISEGKLSKGDTLIETYRFKEGEVHTIKLVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A042</accession>
    <name>I0A042_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="6">PTH</shortName>
            <ecNumber evidence="6">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pth</name>
        <name evidence="7" type="ordered locus">FFONT_0359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0359"/>
    <dbReference type="EnsemblBacteria" id="AFH42349">
        <property type="protein sequence ID" value="AFH42349"/>
        <property type="gene ID" value="FFONT_0359"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0359"/>
    <dbReference type="eggNOG" id="arCOG04228">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073661_2_2_2"/>
    <dbReference type="OMA" id="GHAAVEC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00628">
        <property type="entry name" value="Pept_tRNA_hydro_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034759">
        <property type="entry name" value="Pept_tRNA_hydro_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PTHR12649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="SSF102462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="121" mass="13328" checksum="D2FD7F04C1E4359C" modified="2012-06-13" version="1">MQCKQVIVARKDLRLSPGKLAAQVAHASVECVLQILNSNRNEWKKWLEEWIKEGQKKVVLKVSSLDELLVYYNNAKSLGLPASLIKDAGLTQVPEGTITAVGIGPAPEELVDKITGMLDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A046</accession>
    <name>I0A046_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Flap endonuclease 1</fullName>
            <shortName evidence="10">FEN-1</shortName>
            <ecNumber evidence="10">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fen</name>
        <name evidence="13" type="ordered locus">FFONT_0363</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="10"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0363"/>
    <dbReference type="EnsemblBacteria" id="AFH42353">
        <property type="protein sequence ID" value="AFH42353"/>
        <property type="gene ID" value="FFONT_0363"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0363"/>
    <dbReference type="eggNOG" id="arCOG04050">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032444_0_0_2"/>
    <dbReference type="OMA" id="GSQDYDS"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="1"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0383"/>
    <dbReference type="EnsemblBacteria" id="AFH42373">
        <property type="protein sequence ID" value="AFH42373"/>
        <property type="gene ID" value="FFONT_0383"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0383"/>
    <dbReference type="eggNOG" id="arCOG00076">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_5_0_2"/>
    <dbReference type="OMA" id="MHINLHK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="445" mass="49324" checksum="5CAE749887BC636D" modified="2012-06-13" version="1">MSEIEVVRHYTRFTEESYGVDNGPVPLGSCTMKYNPRIATNYVNSEYLANIHPSLLKFETAQNILKLMYQLQEWLKEITGMDACTLQPPAGASGELTGVLIIKKYFQERGDTQRDEMLIPDSAHGSNPASSSMGGFKSVRIPSDEHGLVNLEALRASVSNKTAGLMLTNPNTLGLFEKNITEVTKILHENEAIVHYDGANLNGIIGIARPGDMGFDIVHLNLHKTFSAPHGGGGPGAGAVCVKKYLEDYLPGYIVSKDDNGRYFLKKMSKSIGDVYSTYGNLPGMIYAYIFILSYGSDIYKVAKYSTLNTNFFISLLKGVKGITLPYDEKTPRLHETVLSFKKLAEETGVTVEDVAKYLLDNGFYAPTIYFPLIVDEAFMIEFTETESYENIVKYAEVVKKAIEIAYTNPSELKQAPINTSVRRLDAVKANHPSTLKPSVKFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A098</accession>
    <name>I0A098_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha-L-glutamate ligase, RimK family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0415</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0415"/>
    <dbReference type="EnsemblBacteria" id="AFH42405">
        <property type="protein sequence ID" value="AFH42405"/>
        <property type="gene ID" value="FFONT_0415"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0415"/>
    <dbReference type="eggNOG" id="arCOG01589">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054353_2_0_2"/>
    <dbReference type="OMA" id="NPTMSWQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013651">
        <property type="entry name" value="ATP-grasp_RimK-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004666">
        <property type="entry name" value="RpS6_RimK/Lys_biosynth_LsyX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08443">
        <property type="entry name" value="RimK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00768">
        <property type="entry name" value="rimK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="109"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="295" mass="33239" checksum="46A56E3F4C6C7AEF" modified="2012-06-13" version="1">MKISVIHPSAIPPFSARQIIREAKARGHSANYIRPQELNVIYVNNSRIIIRGKREIKPEIAFIRGMSYPGSIEHFIWMTNIVKILEETGTFTINSYSSIMTARDKSLLPLILSKNGLPYPKTIITEDLQKALDVINEYGKVVVKPIIGSLGRGVMLLDNVDVAYTVLKQLLSWNQPILLQEFINKKDNRDIRILVINGEIYAAYYRKARPGLFKTNIAQGATPEPAVLDEELKELSIKTTELLGLFYAGIDIAESEKGERYILEANASPNWKGPLSMGLNPARKLVEEAEKTYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0A1</accession>
    <name>I0A0A1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ornithine carbamoyltransferase</fullName>
            <ecNumber evidence="3">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FFONT_0418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0418"/>
    <dbReference type="EnsemblBacteria" id="AFH42408">
        <property type="protein sequence ID" value="AFH42408"/>
        <property type="gene ID" value="FFONT_0418"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0418"/>
    <dbReference type="eggNOG" id="arCOG00912">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_2"/>
    <dbReference type="OMA" id="VYVKNWS"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="16"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="162"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="65"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="143"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ornithine binding" evidence="5">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carbamoyl phosphate binding" evidence="5">
        <location>
            <begin position="279"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="320" mass="37087" checksum="6B2D8E05AF783432" modified="2012-06-13" version="1">MKDMFDFSKIKNFRGRDFITTRAFSREEIDYLIDLAVELKQLRELEIEFLPLRGKTIGMLFRKPSTRTRSSFEVGIAELGGIPFYFRPDEMQLTRGEPVKDTARVLDRYLKGFVIRTFGQDEVEEFAKYMKVPVINALTDLEHPCQVLADLMTIREKKGKWDGLRVVYTGDIWNVAHSLIVEAPRHGMDFIIAVPKGYEPNEEIWKFAEQEARKRGTRLEIVHDLNEAVKGADVVIANTWWSMGKPEQEKDKRKEDFKPFTVTPSHMELAKPDVIFMHCLPAYRGNEMTEEVIEGKWSVVFDEAENRLHTEKAVLTAVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0A3</accession>
    <name>I0A0A3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative Fe-S oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0420"/>
    <dbReference type="EnsemblBacteria" id="AFH42410">
        <property type="protein sequence ID" value="AFH42410"/>
        <property type="gene ID" value="FFONT_0420"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0420"/>
    <dbReference type="eggNOG" id="arCOG00332">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023081_2_1_2"/>
    <dbReference type="OMA" id="VVIHDSC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="219"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="323" mass="37234" checksum="099E539CED3E7D27" modified="2012-06-13" version="1">MKKMTLPIKEILNMMVSFDKKYGIPFPVSTEIIYKWALGTDLPKNTDTVIYTGGLYQLVPYIKEFTNYLESIEEAKGTSIIMKFGERFISLTDFFAKIVVNVSKDELEKQYSIIRNIVELIKSTGTDFGYLYDKDMYTGVLLFDYGLKDAFKEHAESVHKNLKESGVKAVITIDPHTTYILKTIYPKILKDFNINVINYLELLYKFKMKPKREIHESFTIHDPCYYARNLNIITQPRELLLNGGVKINEPFRTKELTFCCGSPVETLSPSLSKEIAKTRLEELVLTSDRIITMCPMCNLSLSRVNEKNASIEDISEVLKKIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0E5</accession>
    <name>I0A0E5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpl13</name>
        <name evidence="5" type="ordered locus">FFONT_0462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0462"/>
    <dbReference type="EnsemblBacteria" id="AFH42452">
        <property type="protein sequence ID" value="AFH42452"/>
        <property type="gene ID" value="FFONT_0462"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0462"/>
    <dbReference type="eggNOG" id="arCOG04242">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076922_1_0_2"/>
    <dbReference type="OMA" id="GMLPWKT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_L13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_L13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="PTHR11545:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="149" mass="16710" checksum="8C10433990C939FD" modified="2012-06-13" version="1">MSEKEIVIVNAENLILGRMASKIAKMLLTGKRVVVVNAEKAMISGERNMVIEGYKKLWSVRTLRNPDKQGPRRPQSPRNIVKRAVRGMLPRKPKGKEALSNLKVYIGIPKEFHGKEMIKFEDVVADLSKGRYISVGELSEALGWRGVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0F1</accession>
    <name>I0A0F1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MATE efflux family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0468"/>
    <dbReference type="EnsemblBacteria" id="AFH42458">
        <property type="protein sequence ID" value="AFH42458"/>
        <property type="gene ID" value="FFONT_0468"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0468"/>
    <dbReference type="eggNOG" id="arCOG01731">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_2"/>
    <dbReference type="OMA" id="TGNQKVG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="458" mass="49616" checksum="CC09B153646C1270" modified="2012-06-13" version="1">MKKLISNVSPQEIQSGNVYKVLVKLGTPLALSEMVQVAYDLANLYWLGRVGKDAVAAPSASWPFTYTFIAAMNGLLASGTTLVSQYRGANNINMMNKSVAQTFVLAIISSLIISVSGILTIPYILYAAGIPSDVYPLSVVYSRIMFVALIFISLWESFRAVVSASGNTITPMKYNFFGVGLNMIFDPFLILGIGPFPMLGVAGAGISTLISRAIVAFISLNNIIQGKSDVRLIKSEMKIDKNILKMMVKIGTPLSVAWVMEALGFSILTAIISMEGSTALAAWGIGDRPLNLLNFATIGFINATGIMVGQSLGASNRKRAEESAEKSLMIISLIGVIGGLIFGAFGRHIASFFIQDPDVIEATIYYYIYMGSTIVFFYYIQLMGAIAQGSGHTRFVMVVSILRIWIIRNVLAYIFGPGPLNMGIPGIWIGMSLSNIISGLVALIWIFKADWKKGVIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0F3</accession>
    <name>I0A0F3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0470"/>
    <dbReference type="EnsemblBacteria" id="AFH42460">
        <property type="protein sequence ID" value="AFH42460"/>
        <property type="gene ID" value="FFONT_0470"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0470"/>
    <dbReference type="eggNOG" id="arCOG01108">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_0_1_2"/>
    <dbReference type="OMA" id="RAHACGH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="1">
        <location>
            <begin position="187"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="391" mass="43332" checksum="DEAF5510797CDDF7" modified="2012-06-13" version="1">MVNILELAREKEKEIVELRRLLHQHPEIAHKEYETHKILVEHLEKIGLHPRTLAGTGIIADIEGKEKGGKTVAIRADMDALPIKEENDVPYKSLNEGFMHACGHDAHMSMVYGAALILNELRDKLNGRVRLLYQPAEEEGTLGGAKPMIEEGALDGVDYILGMHVWPELPEGVIGYRKGPFFAAADTIKITVKGKGGHGAKPNLAVDPIMISAKVVDALHTISSREVDPLEPFVITIGSIHGGTAHNIIPDKVEMLGTVRTLSKELRDSMEERLRRIIRGVTSAFNGDFSLEYLYGYPVLINHQEVTEIMKNVVEGLLGKEKVVESKPTMGGEDFAYYLEKVPGTFMFLGTYNEKMGYIYGVHTSKFNLNEKILPIGSSVFVAGALELMKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0G9</accession>
    <name>I0A0G9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2 superfamily phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0486</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0486"/>
    <dbReference type="EnsemblBacteria" id="AFH42476">
        <property type="protein sequence ID" value="AFH42476"/>
        <property type="gene ID" value="FFONT_0486"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0486"/>
    <dbReference type="eggNOG" id="arCOG03056">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111005_0_0_2"/>
    <dbReference type="OMA" id="HVHWFSD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="73"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="211" mass="23498" checksum="9EB75E04F922296C" modified="2012-06-13" version="1">MIINTAVILALLILRIYGFFSFLDISINSSYGGKYNSFVEIFSETASIYSFVIIGGLIAIYQITRKKKFSKNLLDFASAFIISSVLVLILKDVTKVPRPNATVPPPAGFLSLLSDYYSFPSGHSTRASVASYYLSKKGKIASILSWIYTILIAISRIMLGVHWFSDVVFGIFLGIESSLLVEILSPQLDKLYIKLFGKNRIQLKNKEDGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0I2</accession>
    <name>I0A0I2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpl30</name>
        <name evidence="2" type="ordered locus">FFONT_0499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0499"/>
    <dbReference type="EnsemblBacteria" id="AFH42489">
        <property type="protein sequence ID" value="AFH42489"/>
        <property type="gene ID" value="FFONT_0499"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0499"/>
    <dbReference type="eggNOG" id="arCOG04086">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055156_6_0_2"/>
    <dbReference type="OMA" id="KDYITWG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_A">
        <property type="entry name" value="Ribosomal_L30_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005997">
        <property type="entry name" value="Ribosomal_L30_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_L7/L30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_L7_euk_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="PTHR11524"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01309">
        <property type="entry name" value="uL30_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="149" mass="17368" checksum="D1BCA62D355DB6BA" modified="2012-06-13" version="1">MKGRTNIRHDAEYTLRLFRLYRKYHASIYPSNFPGLSGMLNKIKNYATWGEISREMLIELLKKRGRIVGGEKFTQSILSEKLNVKSIEELADKIINGEIILHEQELIKPVFRLRPPKKGFKRSTRKTFSEGGELGYRGNEINELLKKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0J0</accession>
    <name>I0A0J0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl5</name>
        <name evidence="8" type="ordered locus">FFONT_0507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <text evidence="4">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH42497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0507"/>
    <dbReference type="EnsemblBacteria" id="AFH42497">
        <property type="protein sequence ID" value="AFH42497"/>
        <property type="gene ID" value="FFONT_0507"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0507"/>
    <dbReference type="eggNOG" id="arCOG04092">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_061015_3_0_2"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_A">
        <property type="entry name" value="Ribosomal_L5_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L5_arc"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Ribosomal_L5" evidence="6">
        <location>
            <begin position="21"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L5_C" evidence="7">
        <location>
            <begin position="79"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="188" mass="21320" checksum="F339B4677776E028" modified="2012-06-13" version="1">MISLSTVTEEVNKFIEAWNENPMLKPRITKVTVNVSLGQGGERLAKIAEVLKEITNQEPKLRKAKRTIRDFGIRKGENIAVAVTLRGEKATKFLKKALEAVGNKINKDSFDDNGNVSFGIKEHISIPGVKYDPEIGVFGMDVCITIERPGYRIKRRRVKKAKRIPRRHRVKKEEAIALLSNEFNVRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0K7</accession>
    <name>I0A0K7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0524"/>
    <dbReference type="EnsemblBacteria" id="AFH42514">
        <property type="protein sequence ID" value="AFH42514"/>
        <property type="gene ID" value="FFONT_0524"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0524"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
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    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="PTHR12150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="278" mass="31699" checksum="51529C804F3191EE" modified="2012-06-13" version="1">MKSIEILLPYCSLENEPDQIRITLKANIIARAASIFKVERITLYRSRSDKKSCKDQKEILGLLLRYFVTPPYLKKKIFGKRKELKYVGMAYPLQIPTHSLSKKAKEGDIRVGLVERVKESAIFADIGVGKQVKISNSNYELKRGDLIFVKVKKGDLSELEIIKNPDIYVGYSVRECENPLDYLKEKKKDGLVIGTSKFGDPIWENLKEVEEKLKSSDKVVVVFGEPYRGIFEIFKQLGGNTDDLFHGIYNLVRDQGTKTIRMEEALFIALSLLNVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0M1</accession>
    <name>I0A0M1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0538"/>
    <dbReference type="EnsemblBacteria" id="AFH42528">
        <property type="protein sequence ID" value="AFH42528"/>
        <property type="gene ID" value="FFONT_0538"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0538"/>
    <dbReference type="eggNOG" id="arCOG11497">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3210601_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="44" mass="5238" checksum="69C349B07A2E7C5D" modified="2012-06-13" version="1">MFVLEYAVLKAVVRPRRKGRDWLFIILIAVFAIFVSIRIYEVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0P4</accession>
    <name>I0A0P4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0561</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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</entry>
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</entry>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42600.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="project" value="InterPro"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="7"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="395" mass="44505" checksum="DCC0576F83998370" modified="2012-06-13" version="1">MSEKRGIVIIGGGAGGIITANILAEKGKDVTLISDSNIHPFQPGYLFIAFKGHEPSKYIRTVEELLDPRVKFIQDKVTEVDLKERSIKTEKGKSISYEKVVVATGASLNYDLIPGHRENYEKMGDYYSTPEAAVKVWNNIKDMKKGKLVIGVPDLVIKCPPAPHKGTFLSAGYFKEKRADVRVELLYPAPHVYGEKEVSKAIEEKMKEFGNIDYRTSFLIDSIDNEKKVVRSATGEEVSFDALIMIPMHKGTNIKFNPPEVLDDDRYVKVHKNYLNIEGYDDAFAVGDCTNLPTSKSGVTAHLGAFAIAKRILGEESYFTGRTNCPCITDDEGLFVISDYDHHAVPVRFTRFKRLLEDVFIVMYWASLRYPLKYESIFDTYFKATEPSVLGERGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0U6</accession>
    <name>I0A0U6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoenolpyruvate carboxykinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0613"/>
    <dbReference type="EnsemblBacteria" id="AFH42603">
        <property type="protein sequence ID" value="AFH42603"/>
        <property type="gene ID" value="FFONT_0613"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG06073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_458310_0_0_2"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="594" mass="67695" checksum="AAB96F808ADC1E75" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0U7</accession>
    <name>I0A0U7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0614"/>
    <dbReference type="EnsemblBacteria" id="AFH42604">
        <property type="protein sequence ID" value="AFH42604"/>
        <property type="gene ID" value="FFONT_0614"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011672">
        <property type="entry name" value="DUF1614"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
            <begin position="52"/>
            <end position="74"/>
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        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="254" mass="27809" checksum="3D5CA10DB420621B" modified="2012-06-13" version="1">MQVLSNSGRIIISNPFHPLMLVVYFVIFFPAFLIMPSVFSSLSFFIGLPQGISILIGLSMPMLSFVFSFMNIVIRRIRLEGFFYTIESRYVYFMGIPFPVYYPVYQRREIVIAINIGGAVIPITFSALLLARLYCMSSLYFIDALIVIAITSIITFLISRTVPNVGIATPSLIPPLVSGISALAICGTNYIFPVAYVGGVLGSLIGADVLRLSKDFSKFTHQLGPVFLSIGGAGTFDGVFLSGIIAAIFAYIFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0V1</accession>
    <name>I0A0V1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exopeptidase, family M19</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">FFONT_0618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0618"/>
    <dbReference type="EnsemblBacteria" id="AFH42608">
        <property type="protein sequence ID" value="AFH42608"/>
        <property type="gene ID" value="FFONT_0618"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0618"/>
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        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="400" mass="44570" checksum="A16E2904D017E810" modified="2012-06-13" version="1">MGKNKVYRGYKSWSFLEEGKDYRKFRLAKEIGRVPSKAIPLSKAEEERFESFLENNIVVSVHDHSLVYPEDPGEFMEYARTGRPFIGYEGLSASGLDAVFENMMDGETYTYSPDSWSWENQVFQIGMIQSDVDHQDMVFIGRRVEDIERAHNEGKIAMILSLESAPSIGDDIAKIDALYGLGVRVMGVVYGNNNEFGSGLTSKKDNGLTDLGYGLIERCNKLGILIDVSHAGDRTGMEAVEASKYPVVVTHAGARALWPTRRMKPDELIHAIAEKGGFFGIEAAPHSTLTKNHPVHSIESVMEHFQYVEKLVGIDHVAFGPDTLFGDHVAYHKIFGGASALKALYDLAPNFKSVEYVDGLENPSEFSNIIRWMIKNGYSDEEISKAVGGNVIRVLKSTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0X5</accession>
    <name>I0A0X5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0642</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_0642"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
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        <location>
            <begin position="241"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="419" mass="47690" checksum="B236E99BDB9C1182" modified="2012-06-13" version="1">MKLLAISHGLVLGGAQLSTLEFLELLKDRVEVKVLTCDNAVNSFTQGLRNLGLEVYKVTCLRKLNYPIMLYNPSVEKLVKWADIIWITDIEFTIAYQIKEIKKNIPIVAHLHSYALVCPWWGAYYSFRETCTRRCSIRRIIQCKLGINNELSKVGYLNKRKACIYNGASFLKGPLDYTRWRQLVGDVVDNIDGFIAVSNSLWKIHVAHIPHLGNKPHVIIKNPSVMPLKYISPKPHKAYGNYIVYASGENPLKGPHVLLKAWVAVSKELKDLKLYMIRCKDTCVERQAKKLALKNITFTDYVPPKEHYELMYRARAVVMPSLWPEPFGRIPIEANRLGVPAIVSDTGGLPEIIINDTTGFIFKRGDPGDLITKILKVFDLNFERQRIIDSSFEVVNPSESLNQLLDFFRDITSSSKGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0X6</accession>
    <name>I0A0X6_FERFK</name>
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    </protein>
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    <organism evidence="2 3">
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        <lineage>
            <taxon>Archaea</taxon>
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    </organism>
    <reference evidence="3" key="1">
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42633">
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    </dbReference>
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        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
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        <property type="entry name" value="PS_pyruv_trans"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PS_pyruv_trans" evidence="1">
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            <begin position="15"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="396" mass="45655" checksum="C54ED820F4B4C529" modified="2012-06-13" version="1">MVSVGVLTFHWANHVGAVLQAYCMQSILSDLGFDVEFINYIPKLESLVKTYSDVLKIPRKYSVIRGLLNLSMFSAFRTIVGELANSLYAYKMERLKNEEFEIFRKSHLKLTKPLTSLTELKQAAEKYDYVVVGSDQVWNPIFLMYSDYAYILPFKTSSKKMALAASIGVDPSNIPNHILNYFRLALRDFDFISVREKRHVSILSKLIGRDIYHIPDPVLLVRSEILSNLEQRVEFPFDEFVMVYNLDPTILPLIDKISEDLGLPVVIYSKPYVFPLSQYLQYRRWGKYVSIYNVGPKGFIYLIKKASYVITNSYHGVILSIRFKKSFAIVPGGVASKVPSRIIDLLEELGLLDRVVSNRLKLINTVKKDIDWDNVNLRVEEMSKNAYTLLREAFKR</sequence>
</entry>
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    <accession>I0A0X9</accession>
    <name>I0A0X9_FERFK</name>
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        <lineage>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0646"/>
    <dbReference type="EnsemblBacteria" id="AFH42636">
        <property type="protein sequence ID" value="AFH42636"/>
        <property type="gene ID" value="FFONT_0646"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0646"/>
    <dbReference type="eggNOG" id="arCOG07427">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2597545_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="79" mass="8595" checksum="0DA42601DFF0DF96" modified="2012-06-13" version="1">MEVLLSLKESQEEEGEGTLIECGRYDPVSREILVSLPCLLRSGGNIADKFLETVSHGLVHHCQFAGGPDKVCKVKLGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Z3</accession>
    <name>I0A0Z3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, family 2</fullName>
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    </protein>
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        <name evidence="2" type="ordered locus">FFONT_0661</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42650.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Glycos_transf_2"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
            <begin position="8"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="312" mass="35464" checksum="36167FB6DCB2920F" modified="2012-06-13" version="1">MAEERDTCVVTATYKRAWALPYFIGSLKRQSLLPSKVIFVLKPSGDESEEVIEKEAQGLNYEIVLQKSGNFVEAVELGIKACGGHSLILFIDDDAIASENWIEKYVQFFNLRKDAGGAGGAVYKAIFDGDDISPTGDHFYGRDTYKTKGGIHRRPLPEYEDYCEWLSTSGLPRGKECQGDAILSTLLSGVNMAFRDDAIFDCPLSRLFKNSRKGFHSEQTLAFCARRKGYHTYRLTGESSPVVYHIVEIESLKRRKGFMNDFWIHYDIARDFWRLRELGAEVNFLHYLIGMLILARKKPLARIPATLYALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Z7</accession>
    <name>I0A0Z7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0665</name>
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    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="85" mass="9649" checksum="DA649FFD0095E5B1" modified="2012-06-13" version="1">MLSKRDNLNISASGITVNLILAIAGLAFSYFFLPAFFINFSIINTWLALFNLIPFGPFDGAKIFKADKRVWVVLFVTSLFLFFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A145</accession>
    <name>I0A145_FERFK</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0714"/>
    <dbReference type="EnsemblBacteria" id="AFH42702">
        <property type="protein sequence ID" value="AFH42702"/>
        <property type="gene ID" value="FFONT_0714"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG01073">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="DYQVHPG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="183" mass="21657" checksum="0EA5D513F5196A39" modified="2012-06-13" version="1">MKNMNDFLEISKEELIYSGIRINVKKRKYIYENSEFEKEIVEFGKSAAVLPINDDRIVLIEQFRYPINKWIIEIPAGRVEKGEDPRNAALRELKEETGYTARNIEEVASFFVSPGYSDELMYLYIAEDLKKSEQSLEKGELIRLKELSIKEVKEMLKKREITDGKTLLALYYYLYYYFDKFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A153</accession>
    <name>I0A153_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyltransferase type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0722</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0722"/>
    <dbReference type="EnsemblBacteria" id="AFH42710">
        <property type="protein sequence ID" value="AFH42710"/>
        <property type="gene ID" value="FFONT_0722"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0722"/>
    <dbReference type="eggNOG" id="arCOG04348">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
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        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
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    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="258" mass="29881" checksum="50E0E4CFF6FBF1C7" modified="2012-06-13" version="1">MGVKTPINSENDNAFWKEIILSLSEIVGVYEKANNIMSLFTLKYVREKFFQFVFENIEDGKALRILDAGTGPGTSLVYILKKSGKEHYCIGLDPLPEMINTSRKNFIDLDNVDFVRGVFEHLPFREDTFDLEVSSFAYRDAINYLSVALELSRTLKRSGQLFILDLNKPYEKRIIANFMEKIYMSIFPIFAGTILMGKNGFELYRILKKTYIRLPSSAEIYLIFKKVFKHCKYYVMLHGAVMLLHLKEPIRISSQHKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A163</accession>
    <name>I0A163_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nadE</name>
        <name evidence="9" type="ordered locus">FFONT_0732</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0732"/>
    <dbReference type="EnsemblBacteria" id="AFH42720">
        <property type="protein sequence ID" value="AFH42720"/>
        <property type="gene ID" value="FFONT_0732"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0732"/>
    <dbReference type="eggNOG" id="arCOG00069">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_1_2"/>
    <dbReference type="OMA" id="MAFLYDY"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <source>
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    <sequence length="271" mass="30492" checksum="0B57E0B35475F77A" modified="2012-06-13" version="1">MSDDFAFLEKMDYIKVDGAISSCIKNYLERSNASGYVIGLSGGLDSTVTLYMLVRSVGREKVFGLIMPEIESNLEDINDAIYIAEKLGIKYSVLDITNVVRSALDLFGESYETADKKAKGNLKARARMMILYYFANKNNYLVAATSDKSEYLLGYFTKWGDGAGDIYPIANLYKTQVRQLALYLGVPEKISYKPSSPGLWPGQKATDELKYDYSILDKIIFLLVEKQETVENVSKMLNIEKSDVENIWNTILKNSHKRIPLNSCTVSGVRE</sequence>
</entry>
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                <person name="Ravin N.V."/>
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            <end position="189"/>
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</entry>
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                <person name="Ravin N.V."/>
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</entry>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH42754">
        <property type="protein sequence ID" value="AFH42754"/>
        <property type="gene ID" value="FFONT_0766"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03217">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
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    <dbReference type="InterPro" id="IPR010230">
        <property type="entry name" value="FeS-cluster_ATPase_SufC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43204">
        <property type="entry name" value="PTHR43204"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01978">
        <property type="entry name" value="sufC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="262" mass="29067" checksum="3EF3B907A5E15C2D" modified="2012-06-13" version="1">MEQLTVETISLTASVRDKIIIKNVSLKCNNGEVLAIMGPNGSGKTSLANVIMGHPRYEVISGKIYINGEDVTNLSAHERSLRGLMLLFQSPPEIPGVRLSNIILSSYNKKIGKEVELLKVHRPEVIKEMNEATSEVGLSTDFLYRELNVGFSGGERKRAELLQALVLKPINIIMDEPDSGLDVDGLKIVSNIIKRMKEEDRAVILITHYTRLFKYVEPEKVMLLFNGEKIAEGGSELAKQVDELGYKKFAEKLGITAGDLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1A8</accession>
    <name>I0A1A8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UBA/THIF-type NAD/FAD binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0777"/>
    <dbReference type="EnsemblBacteria" id="AFH42765">
        <property type="protein sequence ID" value="AFH42765"/>
        <property type="gene ID" value="FFONT_0777"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0777"/>
    <dbReference type="eggNOG" id="arCOG01676">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_4_2"/>
    <dbReference type="OMA" id="MIYDALE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="4"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="235" mass="26473" checksum="53306B22ADF25EFD" modified="2012-06-13" version="1">MERYTRQLKILSDEGQRKLKNSTVLIVGVGGLGSASSVYLAYSGIGKLLVVDKDKIEKSNLNRQILYKEEDVGKYKAIIAAERLREINKEIHVEPFVIDVNDENFEEIIKRADVVVDGLDNWKARLRVNKLAVRYLKPFVHAAVEEWYGQLFTVIPKKGPCLNCIFGETEETKKEIQVVPPLPGILGTMQAIEVIKIITGIGKVASDRIIYIDSKNLSIHEIQVTKDPNCKICSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1D8</accession>
    <name>I0A1D8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS</fullName>
            <shortName evidence="1">tRNA(Ile2)-agm2C synthetase</shortName>
            <ecNumber evidence="1">6.3.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA(Ile2) agmatidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tiaS</name>
        <name evidence="4" type="ordered locus">FFONT_0807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>agmatine + ATP + cytidine(34) in tRNA(Ile2) + H2O = 2-agmatinylcytidine(34) in tRNA(Ile2) + AMP + 2 H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:43608"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10626"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83545"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TiaS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.22" evidence="1"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0807"/>
    <dbReference type="EnsemblBacteria" id="AFH42795">
        <property type="protein sequence ID" value="AFH42795"/>
        <property type="gene ID" value="FFONT_0807"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0807"/>
    <dbReference type="eggNOG" id="arCOG01115">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_675459_0_0_2"/>
    <dbReference type="OMA" id="GMCTTYL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002101">
        <property type="term" value="P:tRNA wobble cytosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01892">
        <property type="entry name" value="tRNA_Ile2_agm2C_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013696">
        <property type="entry name" value="DUF1743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024913">
        <property type="entry name" value="tRNA_Ile2__agm2C_synt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08489">
        <property type="entry name" value="DUF1743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUF1743" evidence="3">
        <location>
            <begin position="147"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="2">
        <location>
            <begin position="275"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="443" mass="49671" checksum="2FD64E22572D5AC4" modified="2012-06-13" version="1">MKHLAITLDGYDTNFSGCTTHYTIFLIKKILKEINGAKLVKGPYLVRLNPNIPLKTRGNASVSFLVDVSSGSSVEKILSLHRRYSEKYSSTNERNGKGTILISEDPVDIVKKEAYNIYKKALSDYVPIIEGIRFADKFGLVFEGEKSIIGAVSALGYMYSGDDSTFELLAYRMPGETGERKIDNLTAGKVLLSYKTLFNNFDEKRKLLVASPKGPDPVLIGIRGYEPKDMVDAFYKLKIEEKIWEWCIFKTNQHTDAHKVFRRINDLRVYQAAYIYGTVTKKPEVKKGGHVLIEVSDGSGTIDVIFYSETNPMNEIASRLKEGDNIGILGGAVEKKDEGIIFEAEKLWVYFLSPTVKELNPLCPKCGKRLKSAGKGKGYKCDNCGFKTSEKLEKIKIIEKRDILFGPYTPRSGRIRHLVKPASLESIVLPKANDDIGNRTCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1G1</accession>
    <name>I0A1G1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA-cytosine methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0830"/>
    <dbReference type="REBASE" id="46813">
        <property type="entry name" value="M.Ffo940ORF830P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42818">
        <property type="protein sequence ID" value="AFH42818"/>
        <property type="gene ID" value="FFONT_0830"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0830"/>
    <dbReference type="eggNOG" id="arCOG04157">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006958_2_2_2"/>
    <dbReference type="OMA" id="EPFTGAN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="319" mass="35767" checksum="6A3D042C253226AC" modified="2012-06-13" version="1">MNPKEITVVDLFCGGGGFSRGFHDVGFKVKIAIDNEKNVARTYKYNFLETIVIAEDIKEVSGKDILDALGRAPDIVIGSPPCEPYTAANKKRMNKPLDRLYSDPMGILTLSFFRIVGELKPSIWIMENVPAILEDGLKDALEKEAERSGYKEIYFNILKAEEYCTPSKRTRIFISNIEIKPEKCNKKVTVAEALEGLPSPNPNFPPNHDLTNLSFKKERKVSKISPGEALIRYEGHGGRVLPNMIRLEGNRIAPTVLGSSRFLHPEENRLITVREQARLMGYPDEHVFLGGKDEQYNMIGESVPPTLSKAIAAFLIKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1G6</accession>
    <name>I0A1G6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mn2+-dependent serine/threonine protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0835"/>
    <dbReference type="EnsemblBacteria" id="AFH42823">
        <property type="protein sequence ID" value="AFH42823"/>
        <property type="gene ID" value="FFONT_0835"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0835"/>
    <dbReference type="eggNOG" id="arCOG01186">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1178097_0_0_2"/>
    <dbReference type="OMA" id="FISSMFR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="235" mass="27881" checksum="9639382055B2FD34" modified="2012-06-13" version="1">MSMKNRNIRISFLWQLASFFEQSEVREENGKKIVVKNYIKPNGLIKWFLLNIPIVWFFYQFTVDPLERMKREVNFFESYSGEVLVPKIIEKNFEKYYIKREYIDGRVPNLKSQEDLYRVGVALGNIHNKDFCLGDTRPQNFLILNEDMAIIDAEQSTHECKKKETKAWDLALLFLFEFWDDPLIEPERYFELIDAIYRGYLSSNEDVGWEEIKNIFPVIVLIPPSLLTSIKKALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1H1</accession>
    <name>I0A1H1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3" type="primary">coaBC</name>
        <name evidence="6" type="ordered locus">FFONT_0840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; coenzyme A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0840"/>
    <dbReference type="EnsemblBacteria" id="AFH42828">
        <property type="protein sequence ID" value="AFH42828"/>
        <property type="gene ID" value="FFONT_0840"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0840"/>
    <dbReference type="eggNOG" id="arCOG01704">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_3_2"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="UniPathway" id="UPA00241"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="5">
        <location>
            <begin position="194"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>CTP</name>
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        <ligand>
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            <dbReference type="EMBL" id="AFH42828.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    <sequence length="417" mass="46123" checksum="FA4FEC259F31041C" modified="2012-06-13" version="1">MEKHPSQKIIGEISKELEGKKIVLGVTSSVSAYKSIDLARTLMKNGAEVTVVMSSEATRFISPLMFEWATGNKVYYEKFGGETGHISLSEEYDAMVIAPATANTITKLSFGIADSAVTLAALSFLGAKKPVMVVPAMHIQLYRAPQVQQAINKLKEYGVSLHEPILERDKAKFPDLNELEWHIESFLLRGNDMNGIKFLVTAGPTREFIDTVRFISNPSSGKMGIAIASEALYRGGKVSFIHGPLSVEKIPSFHSTISVISTDEMLNSVISEMKMFDPDVIIMSAAPSDFKPIQTQTKKISSDKPLTLSLEPTPKILKEIVSRKKESSVVISFAADTVDSDEELIKKATEKIEKYRVDAVVANNVSRKDIGFSSDFNEVIIVKNDGEIEKIPRSEKKIVARKLIDVVGEIIEKKRRR</sequence>
</entry>
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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            <name>[4Fe-4S] cluster</name>
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            <end position="356"/>
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    </evidence>
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            <dbReference type="EMBL" id="AFH42833.1"/>
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    </evidence>
    <sequence length="590" mass="67984" checksum="9BB7CA73DAD5638E" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
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    <name>I0A1H8_FERFK</name>
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        <submittedName>
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    <organism evidence="11 12">
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
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    <comment type="similarity">
        <text evidence="2 6">Belongs to the phosphohexose mutase family.</text>
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        <property type="gene ID" value="FFONT_0847"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="term" value="P:carbohydrate metabolic process"/>
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    </dbReference>
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    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
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        <location>
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        </location>
    </feature>
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        <location>
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            <end position="251"/>
        </location>
    </feature>
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        <location>
            <begin position="261"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="7">
        <location>
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            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004326"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00408"/>
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    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="473" mass="52169" checksum="EE5E57AE86534EA1" modified="2012-06-13" version="1">MSGSSRLFGTDGIRGKYLEKVKPGLAYDIGLAVAAHVGGRGTITIGHDIRTTSPLLALSAGSGAMSGGTDAIFLGMVPTPVLAYSVPHTKSKAGIMITASHNPPPDNGIKVFQYNGMEYTERMEDELERIIQVKSEVHASWDQVGRLINAPEIGEDYVDELSSMMSPRTVKYVPRVYVDCSNGAASNYTPRLLRKMGAKVFSANCHPDGYFPAHEPEPRQDVLEPLINVAQPLSPDVILAHDGDADRLSALTIKRGFIKQDHLIALYAKEKLLEGKGTIIVSVDVGNSVSDIVEKYGGRLVRAKLGKLHEKLLEYPGALFAAEPWKLIDPKWGMWVDGIYQAIYLTKLMMEEGLSLDGLLSDIPCYPWARISIPIINDGEKKRELYMLIEENILSTFDGYKTLTKVDGIRLDFDDKTWFLIRMSGTEPKIRLYAEAPTTQKLEELVDKLSKIINEISSKLGVKLGNYNVNKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1I9</accession>
    <name>I0A1I9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">50S ribosomal protein L37e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rpl37e</name>
        <name evidence="12" type="ordered locus">FFONT_0858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
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            <taxon>Fervidicoccales</taxon>
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        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10 11">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 11">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0858"/>
    <dbReference type="EnsemblBacteria" id="AFH42846">
        <property type="protein sequence ID" value="AFH42846"/>
        <property type="gene ID" value="FFONT_0858"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0858"/>
    <dbReference type="eggNOG" id="arCOG04126">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_208825_0_0_2"/>
    <dbReference type="OMA" id="RIRRYSW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_L37ae/L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_L37e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_L37e_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 10 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="7 10 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH42846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="62" mass="7144" checksum="970410174916F5A9" modified="2012-06-13" version="1">MVKGTTSMGKHSNGLTHIRCRRCGRHSFNVAKGYCAACGYGRSKRIRRYSWQNKKVNKERLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1M0</accession>
    <name>I0A1M0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0889"/>
    <dbReference type="EnsemblBacteria" id="AFH42877">
        <property type="protein sequence ID" value="AFH42877"/>
        <property type="gene ID" value="FFONT_0889"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0889"/>
    <dbReference type="eggNOG" id="arCOG06090">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2044512_0_0_2"/>
    <dbReference type="OMA" id="IEPICSY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045057">
        <property type="entry name" value="Gcn5-rel_NAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031165">
        <property type="entry name" value="GNAT_YJDJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31435">
        <property type="entry name" value="PTHR31435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14542">
        <property type="entry name" value="Acetyltransf_CG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51729">
        <property type="entry name" value="GNAT_YJDJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="120" mass="14280" checksum="24A5EA87227ADFD2" modified="2012-06-13" version="1">MSDINVKRTKTVFVAIVGNEEEGEKPFLRYEIDEKNRVIKLIETYTPPKLRGRGIAEKLVDEAVKFAKENELKIEPICSYAIYYFIKHSEKRDLLVDWMKNKNEEELKKIFDEAIQRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1P8</accession>
    <name>I0A1P8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peroxiredoxin</fullName>
            <ecNumber evidence="6">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FFONT_0917</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodecamer. Pentamer of dimers that assemble into a ring structure.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="6"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0917"/>
    <dbReference type="EnsemblBacteria" id="AFH42905">
        <property type="protein sequence ID" value="AFH42905"/>
        <property type="gene ID" value="FFONT_0917"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0917"/>
    <dbReference type="eggNOG" id="arCOG00312">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_4_4_2"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00401">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022915">
        <property type="entry name" value="Peroxiredoxin_TDXH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="9"/>
            <end position="165"/>
        </location>
    </feature>
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            <position position="51"/>
        </location>
    </feature>
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        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
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    </feature>
    <feature type="disulfide bond" description="Interchain (with Cys-213); in linked form" evidence="6">
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            <position position="51"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="6">
        <location>
            <begin position="207"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with Cys-51); in linked form" evidence="6">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="HAMAP-Rule" id="MF_00401"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="217" mass="24790" checksum="960C418BE3AC6DEA" modified="2012-06-13" version="1">MSSNVNVMPKIGEKAPSFEASTTYGRIKFPDDFKGKWVVLFSHPADFTPVCTSEFVAFQKRIKQFEELNVQLIGLSVDQVFSHIKWDEWIREKFGIEITFPIIGDNTGRVASLFGMLHAQAEGSSTVRAVFIIDPEGIIRAILYYPQELGRNIDEILRMVKGLQTSDKYGVAIPANWPNNELIGDKVILSPVDNKNDIPERLKKHECFDWWFCYKSI</sequence>
</entry>
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    </protein>
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_0923"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000007391">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="122" mass="14352" checksum="6AD5C2D148BCC55D" modified="2012-06-13" version="1">MQKKSQEFLKSLVDGEIILAVYLLRLEEGIITYWPPEYYDDEIEKISDLTSVPLKEGLYFVLGGDRLKEKYIGLVINKNILLFRVRDDFNAEKIAEKLSSAYLKYLNDRGKLENNFFNDKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Q7</accession>
    <name>I0A1Q7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Archaeal flagellar protein FlaG</fullName>
        </submittedName>
    </protein>
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42914">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="162" mass="17341" checksum="8812081E813A3156" modified="2012-06-13" version="1">MGESTTITHALLTIAAITIASIFAFVMISKISAINSSITQMISSNVNNMESSITIIDFFYNSSGGSFVIYVKNVGTSDISLSALQNTDVYIGTYNSPLTLYTYLSSAYPGHWNYTLAIGGSNSWSAGSTIIIYLYNQTSISPPYYVKIVLPIGIGSELVEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1U1</accession>
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        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
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        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">Involved in protein export. The function of the beta subunit is unknown, but it may be involved in stabilization of the trimeric complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 14">Component of the protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. Can form oligomers of the heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cell membrane</location>
            <topology evidence="1 14">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC61-beta family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH42948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0960"/>
    <dbReference type="EnsemblBacteria" id="AFH42948">
        <property type="protein sequence ID" value="AFH42948"/>
        <property type="gene ID" value="FFONT_0960"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0960"/>
    <dbReference type="HOGENOM" id="CLU_208205_2_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023531">
        <property type="entry name" value="Preprot_translocase_SecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0811">Translocation</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 14" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFH42948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="58" mass="6179" checksum="5D13D28F895C81E0" modified="2012-06-13" version="1">MSSKSKEKKKKPSGLMSAAGLISFYEDTSAKITITPTTIIIISIAFIGIVVALRVLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1U3</accession>
    <name>I0A1U3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">RNA 3'-terminal phosphate cyclase</fullName>
            <shortName evidence="5">RNA cyclase</shortName>
            <shortName evidence="5">RNA-3'-phosphate cyclase</shortName>
            <ecNumber evidence="5">6.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rtcA</name>
        <name evidence="8" type="ordered locus">FFONT_0962</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 3'-end 3'-phospho-ribonucleotide-RNA + ATP = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10463"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83062"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.5.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.4" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0962"/>
    <dbReference type="EnsemblBacteria" id="AFH42950">
        <property type="protein sequence ID" value="AFH42950"/>
        <property type="gene ID" value="FFONT_0962"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0962"/>
    <dbReference type="eggNOG" id="arCOG04125">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027882_0_0_2"/>
    <dbReference type="OMA" id="PKPGLSH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003963">
        <property type="term" value="F:RNA-3'-phosphate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00200">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017770">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020719">
        <property type="entry name" value="RNA3'_term_phos_cycl-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="PTHR11096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF0">
        <property type="entry name" value="PTHR11096:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005378">
        <property type="entry name" value="RNA3'_term_phos_cycl_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52913">
        <property type="entry name" value="SSF52913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03399">
        <property type="entry name" value="RNA_3prim_cycl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01287">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RTC" evidence="6">
        <location>
            <begin position="12"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="RTC_insert" evidence="7">
        <location>
            <begin position="184"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="5">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="362" mass="39356" checksum="1E61552BA011107D" modified="2012-06-13" version="1">MNKIITIDGSLGEGGGQILRTSLALSAILGMPLKVINIRAKRENPGLQHQHITAVKVVSALSNAKTEGLYLGSKELLFYPNKLSGGNFEFDVGTAGSVMLVLQAILPILPFLETSTKIVLKGGTDVPGAPTFDYFKNVTLELLKRIGIDMKANIKRRGYYPKGGGIVDIFIESPKGRLKNIELVKRGELKKIKIFSVAHKLPSHIAKRQALSAQSFLEERLQGILYETEIEDDEKNHELASFSPGTSISIIAEAKESILGGDSLGKKGKPAEKVGEDAAKVLIEDISTQMALDRFMSDMIIPFLALAKGKSKVGGSRLTLHAITNILVIEKILNIKAKVLGKQEEPFIVEVDGIDPFSLYVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1U6</accession>
    <name>I0A1U6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
            <ecNumber evidence="9">3.4.25.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">20S proteasome beta subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Proteasome core protein PsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">psmB</name>
        <name evidence="11" type="ordered locus">FFONT_0965</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="9"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0965"/>
    <dbReference type="MEROPS" id="T01.002"/>
    <dbReference type="EnsemblBacteria" id="AFH42953">
        <property type="protein sequence ID" value="AFH42953"/>
        <property type="gene ID" value="FFONT_0965"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0965"/>
    <dbReference type="eggNOG" id="arCOG00970">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035750_7_2_2"/>
    <dbReference type="OMA" id="HKQAYAI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02113_A">
        <property type="entry name" value="Proteasome_B_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019983">
        <property type="entry name" value="Pept_T1A_Psome_bsu_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03634">
        <property type="entry name" value="arc_protsome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="7 9 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="8 9" id="KW-0865">Zymogen</keyword>
    <feature type="propeptide" id="PRO_5005059557" description="Removed in mature form; by autocatalysis" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023308971" description="Proteasome subunit beta" evidence="9">
        <location>
            <begin position="20"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9 10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="211" mass="23264" checksum="A34AF68640745B1B" modified="2012-06-13" version="1">MYFDRNVKNSEIYEKALHGTTTVGLIAKDAVILAADRRATAGTFIAHRKTRKILKITDKMALTTAGLVADAQVLADWLNTQMNYLTITKKQPVTVREAAHLLSLLLYRYKLFPFYVQLILGGYDTAPRLFSLDLYGSLVEEKYTSTGSGSPIAIGVLEDGYRENMSPEEARKLAVKAVQMALKRDSATGDGVDSVIITSEGIKEFSDPVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1V6</accession>
    <name>I0A1V6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0975"/>
    <dbReference type="EnsemblBacteria" id="AFH42963">
        <property type="protein sequence ID" value="AFH42963"/>
        <property type="gene ID" value="FFONT_0975"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0975"/>
    <dbReference type="HOGENOM" id="CLU_1248249_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="221" mass="26423" checksum="5DA406DA640A33A3" modified="2012-06-13" version="1">MFKNIPNYPEIPVLRESGMIYPPVAFIIYMINPFVSPDVLFLYNIYLRANLEANKEIFVGSYGEDVENLISVSSYPTPLISKLREFLSLTNIHYRYYTSIEEMIKSLELNFRSADHIYYYIPYLSENDEKMLFRLVQSVKKAKQNTNKNLTITFFIDENVIGNRNSYMLYDGDILFKAYFDEKTYRRYIKLIKMRFFEPRSINIEYVIDNDIIRFNLIRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1W0</accession>
    <name>I0A1W0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histidine triad (HIT) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0979</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0979"/>
    <dbReference type="EnsemblBacteria" id="AFH42967">
        <property type="protein sequence ID" value="AFH42967"/>
        <property type="gene ID" value="FFONT_0979"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0979"/>
    <dbReference type="eggNOG" id="arCOG00419">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_1_2_2"/>
    <dbReference type="OMA" id="YNPGHVM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="3">
        <location>
            <begin position="28"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2">
        <location>
            <begin position="123"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="167" mass="19250" checksum="B626561B4AAC91FE" modified="2012-06-13" version="1">MRKMKILWAPWRSVYIKEISKEEKGSCIFCKVIAEKDDNKNLVVFRGNKTFVIMNKYPYNSGHLMVVPYKHVSRIENLDNEELLELSTLIVRSVKVLTELYRPDGFNIGMNIGRAAGAGIEDHIHVHIVPRWIGDTNFMPVIGETRVISENLTEAYAKIKEAFQKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Z3</accession>
    <name>I0A1Z3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carbamoyltransferase</fullName>
            <ecNumber evidence="8">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">FFONT_1012</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="13" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1012"/>
    <dbReference type="EnsemblBacteria" id="AFH43000">
        <property type="protein sequence ID" value="AFH43000"/>
        <property type="gene ID" value="FFONT_1012"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1012"/>
    <dbReference type="eggNOG" id="arCOG01187">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009164_0_0_2"/>
    <dbReference type="OMA" id="VQHHYAH"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="10">
        <location>
            <begin position="4"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="11">
        <location>
            <begin position="203"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AFH43000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="770" mass="85521" checksum="9C21B2C053993069" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A209</accession>
    <name>I0A209_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FFONT_1028</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1028"/>
    <dbReference type="EnsemblBacteria" id="AFH43016">
        <property type="protein sequence ID" value="AFH43016"/>
        <property type="gene ID" value="FFONT_1028"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1028"/>
    <dbReference type="eggNOG" id="arCOG00403">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_0_1_2"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="PTHR11778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="210"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="41"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH43016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="459" mass="52957" checksum="C1154E48EC92E5DB" modified="2012-06-13" version="1">MPKWTVLEYLRNNPDEYMQMVKRRGLDESIVREAIEIDKAYRSKLREVENLRREHNSLTKELSKENNQEKKNELLRKAKEILQLLEEKEKEVSEAERNWYDSLKKLPNILAPDVPYGTSDEDNLPVKFWGRPKVTTDKLEEFKKQTEKWGFKVDFDLVENKSFIGHADMLEKVLNMADTNQAAKVAGSRFFYLIGDIVWLDFAISLYALDVITRKGFIPIIPPYMLRTEVLEGALDYSSFKDMIYKIENEDLNLIGTAEHPLMGLAYDNPIREQDLPLKLVGWSPCFRREAGAGNRDLKGIFRVHQFHKVEQFVFAHPDNSWKFLDEMVANTEEILQGLGLPYRVVNVVSGELGLPAAKKYDIEVWMPAQGKYREIASISQVLDWQAFRANLTYIKASDGRREYLHTLNGTGIPTTRAISAIVENFQDEEGNVAIPSVLKKYLENIPGAPTDVLKPRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A229</accession>
    <name>I0A229_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-guanine(15) transglycosylase</fullName>
            <ecNumber evidence="1">2.4.2.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-deazaguanine tRNA-ribosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Archaeal tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tgtA</name>
        <name evidence="3" type="ordered locus">FFONT_1048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:43164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10371"/>
            <dbReference type="Rhea" id="RHEA-COMP:10372"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82850"/>
            <dbReference type="EC" id="2.4.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; archaeosine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the archaeosine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.48" evidence="1"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1048"/>
    <dbReference type="EnsemblBacteria" id="AFH43036">
        <property type="protein sequence ID" value="AFH43036"/>
        <property type="gene ID" value="FFONT_1048"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1048"/>
    <dbReference type="eggNOG" id="arCOG00989">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030083_0_0_2"/>
    <dbReference type="OMA" id="FPCSCPV"/>
    <dbReference type="UniPathway" id="UPA00393"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01634">
        <property type="entry name" value="TgtA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
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        <property type="entry name" value="TgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00432">
        <property type="entry name" value="arcsn_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="2">
        <location>
            <begin position="10"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="505" mass="58579" checksum="3AB1A974E791029F" modified="2012-06-13" version="1">MDIMDKDLAGRIGRIKIKGKTIETPYLFPVIDPTRQEVPISSIKSMGFNGVITNAYLAYKRGWNRDIHELIGDGELVVMTDSGAYQLMQYNNIEVSNEEIIKIQKGLNSDIAVILDVPTGDSLDQNYAKWTAEETLRRASEAQKIIDRDNRMWVLPIQGGIHLSILEESSKKSSQLEYDIYAIGSPTKFMERYRYDVVLDMIRIVRENIRADVPLHLFGAGHPMIIPFAVAMGVDLFDSASYILFARDGRYMIEGGTLRLEDIEYFPCSCPICSRYTPKELKNMNKDERTRLLAEHNLYMIKKILNEVKQAINEGRLWELLQSYSRKHPSLYSAFNNIKNKHVEWMEKYTPRVKGEQKAIYLFDNDSMFNPKILRARKYIMQNYMPPSEFKEVVFLYATYKNQRKFEEGKHYIYYAPGIGLIPQELSGTYPWGQNVIPSKISYETMQSIANDVVKYIEKFSDKYLKVSIGICDEMSIMQEKISSLLDEETKEKVYFFKDSCENEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A238</accession>
    <name>I0A238_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Exonuclease of the beta-lactamase fold involved in RNA processing-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1057"/>
    <dbReference type="EnsemblBacteria" id="AFH43045">
        <property type="protein sequence ID" value="AFH43045"/>
        <property type="gene ID" value="FFONT_1057"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1057"/>
    <dbReference type="eggNOG" id="arCOG00545">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050517_0_0_2"/>
    <dbReference type="OMA" id="DHADFPS"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="354" mass="40427" checksum="48C153EB593CA7B7" modified="2012-06-13" version="1">MLFLLTELKPIINASITESGAILLGEFFEIDSYAGRPVRVVTHMHSDHTLYLSKSKRHSTYILATQPTLDSLTVLGEKLPENKTIPLGYNKPLRIVDETITFVKSTHVIGSAQVVVETKEGFRLGYTSDFKFPGTKIMSDLDVLVIDATYGQEHMIRPFKQEIETLLADLVNEILSKNKPVRILGYYGKLQEVMEILRKNNVSAPFVMPKKVYELTNVACKHGMKINDFFEEDSKEGSEVKKDNWYVYFQHMNSKKGTLSQTADLILSGWFFESPIKKIIEKNKYEKWLVAFSDHGDFQDVFAYVSESKPKMLIVDGSRTDRVTADFFSNFVKKKLNLKSSVLPSQKIQLKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A258</accession>
    <name>I0A258_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anion transporting atpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1077"/>
    <dbReference type="EnsemblBacteria" id="AFH43065">
        <property type="protein sequence ID" value="AFH43065"/>
        <property type="gene ID" value="FFONT_1077"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1077"/>
    <dbReference type="eggNOG" id="arCOG02849">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040761_4_0_2"/>
    <dbReference type="OMA" id="FGYKLDA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="Anion-transp_ATPase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="PTHR10803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ArsA_ATPase" evidence="1">
        <location>
            <begin position="13"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="306" mass="34728" checksum="6C7530B73FC2D331" modified="2012-06-13" version="1">MTLSQILPKEKGLVMIVGKGGVGKTTFSAILSIYASKQLPTFVTSIDPAHHLGDVLGYKLEHREKRIAENLIANEADIDELIREYLSKSINLLKNSYKDITALNLDKYFDTLKDSPGIEIEAMLHYIVSLVRKVDEYKYIIVDTPATSITSRLIGLPWVQGVWVDNLIDLRSKIAGLKEVIESVKAGKKVTIDDKILKELIQMREEIERNKKLFMNSDFTKIIGVTTTEKLPIVDLERLSNSLKNRGIKISSVVINKYKKDENGLSVINYLKEKFPEARLILVPQMNYEVISIEKIEKVIEKIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A295</accession>
    <name>I0A295_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1114"/>
    <dbReference type="EnsemblBacteria" id="AFH43102">
        <property type="protein sequence ID" value="AFH43102"/>
        <property type="gene ID" value="FFONT_1114"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1114"/>
    <dbReference type="eggNOG" id="arCOG01015">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028780_2_0_2"/>
    <dbReference type="OMA" id="DGGLYIK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005912">
        <property type="entry name" value="Pus10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="PTHR21568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01213">
        <property type="entry name" value="pseudo_Pus10arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="THUMP" evidence="5">
        <location>
            <begin position="25"/>
            <end position="191"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF02926"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH43102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="422" mass="47728" checksum="7F09C68F6D76E6BA" modified="2012-06-13" version="1">MENEVLSKAISIMEKYPLCDSCLGRMFSSFLKGFTNEERGKAIKIAIAMELIKKLKSGEEEAGKKLEAISQSLGPEFDKTLEEVNIKRRTGECYLCGGKLKKWVSLYKEAVPILKKKSVESFVVGITGSKEIETKEDELLREFSIDTAESIKSELRREVGKLITSSTGIDAGFTDPGAVIYIDLKSENLRVKVMPLFIKGRYIKAGRNISQVEWFDDDKKQQLSVKGMLSVLSEFYGGEVLLHASGREDVDVRMLGWGRPMVVEIKDPRTRRVPLSYISWLVNKNPYGIFILEEKGKRKDVREIKELDSKKRKIYRIVVAGDVPLNEKDADTIVRELKGKVIEQRTPTRVLVRRKDVARRKKVYDISLHAFSGVLIGLIETDGGLYIKELISGDNGRTKPNFSEILGKSVQCIELDVVKVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2A6</accession>
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            <fullName evidence="3">Major facilitator superfamily MFS_1</fullName>
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    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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            <taxon>Archaea</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43113">
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    </dbReference>
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    </evidence>
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            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH43113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="479" mass="51823" checksum="5294AB799B4F2791" modified="2012-06-13" version="1">MKTSDNRRILEVLSVTTLASFIAGFNARLAVVGLPTIAGEIGADVWSMIWIIQGFMLGSTIFQLIIGRLTDLYGRVRLFTIGIGIFTIGALLSGLSSNPAFLIISRTVQGIGGAFLMSISITILTDNVPPSRLGTWLGVNQVAWRIGALLGLTLSGFIIDLLSWHWIFLIQVPIGVIVLFWTRIRLKEVYKPKENIFIDIKGFTFFTLSLTLSLIGLTMVGYGYRDYSYILLALSVAFLAIFVYSELKTTHPALDLRLFKIWQFSGGIISQLLYSIGFGASLTLLAIYMQSVLGYSPSETGILLVPYEASFLVFGIIGGRLSDILGFAPVTVAGLAVGSISLFLLSLAGSIPMIIFAEVILGVGTGLFVSPNTSSIMTSVPPDRRGVASSIRTVSFNVGFAISLNIAILTMTQKIPYTLASHLIVLGGILPSDSSLTIELTELGEAIKHSFLVQALIMALAIPFSISRMKKVEMNKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2B2</accession>
    <name>I0A2B2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoglycerate mutase</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ordered locus">FFONT_1131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH43119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1131"/>
    <dbReference type="EnsemblBacteria" id="AFH43119">
        <property type="protein sequence ID" value="AFH43119"/>
        <property type="gene ID" value="FFONT_1131"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1131"/>
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        <property type="reaction ID" value="UER00194"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0046537">
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    </dbReference>
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        <property type="entry name" value="Metalloenzyme"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH43119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="426" mass="46667" checksum="4870AE382ABAF2AA" modified="2012-06-13" version="1">MKLVYLVLDGAAGDPNLGKTAYMIADKPNLDSLAYKSKCGLMYVIGKGIAPESDAAVLALLGYDPINEHPGRGPIEALGVDIELKEEKEVAFRGNFATVDPLTKKIIDRRAGRGINKEEANELASLIDGIQLLNGKGYAKVKATVGHRVVVVLGHKEKQLGDEVSNTDPAYERRGKVSVALENFDATIKPCIPLNQDEKNRITCELVNEFTERAIKILSSSKVNESRLKNGMLPANAILLRDAGTGKAKMKDISAMYSNLKFSALTEMPVEKGIAKAAGMKMIDVSSISGERKHVYEQWALKTIEALSVSDVVYVHLKGPDEPGHEGNLKLKTKIIEDIDKYYLGSIVKYLEKEDIAILVTSDHATPCEKKAHSDSPVPFLLYSKNFSDGDRIKRFDEVECKSGSFGLISEGKNLLKTVLSFLKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2C2</accession>
    <name>I0A2C2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine hydroxymethyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FFONT_1141</name>
    </gene>
    <organism evidence="10 11">
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        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1141"/>
    <dbReference type="EnsemblBacteria" id="AFH43129">
        <property type="protein sequence ID" value="AFH43129"/>
        <property type="gene ID" value="FFONT_1141"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1141"/>
    <dbReference type="eggNOG" id="arCOG00070">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_2"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SHMT" evidence="9">
        <location>
            <begin position="22"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH43129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="436" mass="48708" checksum="46875F4BE2867150" modified="2012-06-13" version="1">MVIKLSSPENLLRNVLQLTNEANEWRRKKSINLIASENVMSPLAEAVYLSDFMSRYAEGKPKKRYYQGTKYIDELEIMLAELMGKILNIQYIETRPISGTIANASVFKELGEPGDRALVAPVQAGSHVSHTKFGTLGALGMTQVYLPYDEERMNVDVDKAIKMIKEEKFKFLVLGGSVYLFPHPVKELADAVKERGAKIVYDAAHVFGLIVGGVWRNPLREGADVMTASTHKTFPGPQGGLIAFSDEGLYKQVSKTIFPYFLSNHHLHRIPATLVTTLEMMKYGEQYAKAVVENAKKFAEALAEEGFKVLGENLGYTMSHQVVVDVAKQGGGAKCATLLESANIITNKNLLPYDPPENVQNPSGLRLGTQEMTRYGMGKQEMYEIAHLMRRLLIDNEDPEKVKKDVIELRSGFLEVKYGFTLEDAGDLKDKILILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2C5</accession>
    <name>I0A2C5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1144"/>
    <dbReference type="EnsemblBacteria" id="AFH43132">
        <property type="protein sequence ID" value="AFH43132"/>
        <property type="gene ID" value="FFONT_1144"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1144"/>
    <dbReference type="HOGENOM" id="CLU_716890_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="385" mass="44614" checksum="DA3825D965314BB8" modified="2012-06-13" version="1">MNGFNIVGLKEIVQILKNNSAAKKALDEKFDNENIMIIDYYNEEVSIGNSIEKTRKILWSEATTPMKNTSWLPIKTIHETNTKISASNIIGIVNPFPITFIQEIEGEKYFFKGEGTGPYELNDNDRNVKKISRKNQTKIGKELNIGPININFNESCEKTLTPEITYYFCSGNELFMFKEGNMFQVNKKSDIRINTISINSLVQWIQPYRIVIDTLSHGEKLSSNFIILSQPSFSITFASLYPITLKHEEKEIFVENRGKTIISLDTLPNYSLLSYLRVFVDENNLFSSKLPKVQINDPSTFLHSQKIKDLSEREFEYELYACNVLSYDKVLRIYVKPPFYMREFYINNIEQNPEKISVDTNTIVLPLPKYKCLKIKLIAREKIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2F8</accession>
    <name>I0A2F8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Metal dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1177"/>
    <dbReference type="EnsemblBacteria" id="AFH43165">
        <property type="protein sequence ID" value="AFH43165"/>
        <property type="gene ID" value="FFONT_1177"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1177"/>
    <dbReference type="eggNOG" id="arCOG04230">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068640_0_0_2"/>
    <dbReference type="OMA" id="LHAILCH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039967">
        <property type="entry name" value="MJ1020-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40517">
        <property type="entry name" value="PTHR40517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="267" mass="29883" checksum="055B219DBF981CFD" modified="2012-06-13" version="1">MLQREEVVVSPQLLEKQLSKEPFLKKAYEIALRDEELQVLLEHSNVMAVKRLKYNDHGPTHAKIVSGSSLEIFDRIFSAGIEPTTIKDGIFQKTEEAKLVVLLGSLFHDIGNSIHRINHEFIGMLMSASILDRILSSIFPNDKRKAILMREEVLHAIYATSYTVPALTIEAGCVKVGDGTDMSEGRARIPYRLGKNDIHAISALSIDKVTISSEDETPVVITIYMKERAGVFQVEQVLYPKIATSGIKKYVKLKAVWGGKEMKMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2G0</accession>
    <name>I0A2G0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin reductase (TrxB-3)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1179"/>
    <dbReference type="EnsemblBacteria" id="AFH43167">
        <property type="protein sequence ID" value="AFH43167"/>
        <property type="gene ID" value="FFONT_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1179"/>
    <dbReference type="eggNOG" id="arCOG01296">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031864_5_3_2"/>
    <dbReference type="OMA" id="VDNFPGY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019430">
        <property type="term" value="P:removal of superoxide radicals"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005982">
        <property type="entry name" value="Thioredox_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01292">
        <property type="entry name" value="TRX_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="17"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="325" mass="36059" checksum="A373ECFD66071625" modified="2012-06-13" version="1">MSLRLQVKKPKEQSTEYDVAIIGSGPASLSCGLYSARYRMKTIIIGDTIGGQLNLTNIVENYLGFPKITATDLISRFKKHVEEYDVEFNLDRVNSIKKEGSYFIIRTVNGKEIKAKSIVLAIGLKRRKLNVPGENEFAGKGVSYCSICDAAFFKDAAAVAIVGGGDSALEGALLLSEYAKKVYLIHRRDQFRGQPILVNAVKSRKNIEIVYNSIVKEIKGDKKVNSVKIKNVVSGEERELQVNGIFIEIGFEPDIELPRSIGIELDENGFIKVNEYMSTNVEGVFAAGDCTNMWKGFRQIITATVQGAVAAYSAYKYLSEKWNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2G3</accession>
    <name>I0A2G3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1182"/>
    <dbReference type="EnsemblBacteria" id="AFH43170">
        <property type="protein sequence ID" value="AFH43170"/>
        <property type="gene ID" value="FFONT_1182"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1182"/>
    <dbReference type="eggNOG" id="arCOG00065">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="25"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="411" mass="46313" checksum="8A3DF0084F309B1A" modified="2012-06-13" version="1">MGLDVEQIREDFPILKQEVRGKQIVYFDNAATSQRPIQVINAIKKYNEELNSNVHRGHHYLSKKSTELYEEAHEIVAKHINADSWQEIIFSLNTSYAVNLMAYPLVMRGLKEGRDKIVITEMEHHSNMLPWRNAAKIFGARVEYARVDKDGYIDVKRLINKLDEKTSVLAITHASNVTGIINPIENISKEAKKYGITVFADVAQSIPHLSIDVKKLGADFIVFSGHKMLGPLGIGVLYGKLEMLREIDPFIVGGGTIKDVTLESVMYDEPPYKFEAGTPNVSAAVGLMEAVKYLEKVGKDNIIQHERMLLMKARKGLSEVEKIKLYPKDLKSESTGTLAFNIDGANPHIVGSVLNDFYAIAVRTGLHCAHPYHYAIGANEGTIRASFYLYNTESEIEYFIRSMSEIVKKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2H5</accession>
    <name>I0A2H5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_1194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1194"/>
    <dbReference type="EnsemblBacteria" id="AFH43182">
        <property type="protein sequence ID" value="AFH43182"/>
        <property type="gene ID" value="FFONT_1194"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1194"/>
    <dbReference type="eggNOG" id="arCOG04293">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_209471_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_S30"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="46" mass="5362" checksum="402DA6064871326A" modified="2012-06-13" version="1">MTKAGKVRNQTPKIEPKGRKNKPPIVRNRIEYFVRVVKPTLSSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2K4</accession>
    <name>I0A2K4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1223"/>
    <dbReference type="EnsemblBacteria" id="AFH43211">
        <property type="protein sequence ID" value="AFH43211"/>
        <property type="gene ID" value="FFONT_1223"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1223"/>
    <dbReference type="eggNOG" id="arCOG04153">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142666_0_0_2"/>
    <dbReference type="OMA" id="PANCEIL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="137" mass="15617" checksum="718CF3593A5511D9" modified="2012-06-13" version="1">MNLLKSKNTTLPKDIENTIIKILESSGNSGMNLSELQKILKIKEDKLKLVVARLSRKGIVKKEKIKKEDGKIDYKIQLSTIKPVELKIELSTVIKIPCFTCKYIKECGIGREWSPANCEILKNWLESETNKIEQASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2L5</accession>
    <name>I0A2L5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YbaK/prolyl-tRNA synthetase associated region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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            <begin position="20"/>
            <end position="136"/>
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    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43222.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="147" mass="16619" checksum="57B42FAE390BFDAB" modified="2012-06-13" version="1">MNYEVIDNLKVEVLEFSGTVETVEKASLLSGEPREKIAKTLLFKLNNEYVVFIVRGDRKVDYIKANDILGTKPQLASPEDVKRILGTEPGAVSPIDRQIKKLKIFLDPKILEEEYILCGGGSKNKLYKVKTSDLISYLNPNMLDIFK</sequence>
</entry>
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    <accession>I0A2L7</accession>
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            <fullName evidence="2">Aspartate aminotransferase</fullName>
        </submittedName>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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            <taxon>Fervidicoccus</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH43224">
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        <property type="project" value="UniProtKB-KW"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="367" mass="40759" checksum="010A487F48078342" modified="2012-06-13" version="1">MEVKIPISKPIIEQDEIDAVIEVLKSGMLTRGKNTELFEKEFASYIGTKYAVTVTNGTVALEAALKALGVGEGDEVIVPDFTFIATANAVVNVGGRPVFADIDERTYCIDPESVNEKITNRTRAIIPVHLFGHMADMNSINEIAIDNKLVVLEDSAQAHGAEMNGVKAGSIGHASAFSFYATKNMMTGEGGMVTTNLDAVYEFLVKWKKHGEAKRYLSDTLGTNLSMTEMQAAIGRVQLKKLDRFNEIRRQNAAYFTKELSKVKEIKTPVELPGYKHVYHQYVIRVPAEDRDKLIEHLNKLGIGTAIHYPYPLHIQPIYKAMGYPEKQNPVSLEVSKEVLSIPVHPLLSKSDLEYIVKGILSYFNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2N4</accession>
    <name>I0A2N4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC-type sodium efflux pump system, permease component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH43241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="AFH43241"/>
        <property type="gene ID" value="FFONT_1253"/>
    </dbReference>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="23"/>
            <end position="46"/>
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        <location>
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            <end position="273"/>
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        <location>
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            <end position="357"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
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            <end position="380"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="429" mass="47243" checksum="C8388941EF7063C5" modified="2012-06-13" version="1">MSRSEFLTLAKKEVKDLFRDPKIIITMLVVPIVIFFILGEVMGYSISKTSEISNMTGVNIAVINYDNGTFSQYFINFIKNDLNSNVKVFANGTVYDLMRNGNYLIVFVIPNNFTYNIVNGVSANIESYTYIKEISISSLSQVSLASNLIISSFNRMVLLSYLAKAYPNMNATFFLNPVSANESVFINGNILPANTIESLTGPYTALIIAPILMFSIASSISASSMGTEKEEKTLEITLSLPVKRSYILLSKVLSSFVVSLIGLIGMSTAMLYYEYKIFSSTGISEAGGLNISSASSIISPTVLFLFALGFLFAIFVILLISIVASSLANNIREAQIIASYIWLPFLIPYILLIYVNISQLGSFGAFIVSILPASTPIIAIKSVFLGNYIYLLTSFIANILYIAIILYIGTKWFSGERIISSRPILSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2N7</accession>
    <name>I0A2N7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">30S ribosomal protein S19e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rps19e</name>
        <name evidence="5" type="ordered locus">FFONT_1256</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in maturation of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1256"/>
    <dbReference type="EnsemblBacteria" id="AFH43244">
        <property type="protein sequence ID" value="AFH43244"/>
        <property type="gene ID" value="FFONT_1256"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1256"/>
    <dbReference type="eggNOG" id="arCOG01344">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108559_1_0_2"/>
    <dbReference type="OMA" id="YIDGPVG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01474">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_S19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027548">
        <property type="entry name" value="Ribosomal_S19e_archaeal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="PTHR11710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="154" mass="17635" checksum="AC5D2FF6BBE1E688" modified="2012-06-13" version="1">MVNAMQVPPSILVERLAKYLKENYSEVINPPEWSKFSKTGSYKEYIPLQEDWWYYRAASILRKLYKAKGPVGIERFRVIYGGKKRFGSSPPHFRKGSGAIARNILKQLEKAGLVTRISGKGRTLTPNAVSLLDRISKEIMSELAEQTPELKRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Q0</accession>
    <name>I0A2Q0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1269"/>
    <dbReference type="EnsemblBacteria" id="AFH43257">
        <property type="protein sequence ID" value="AFH43257"/>
        <property type="gene ID" value="FFONT_1269"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1269"/>
    <dbReference type="HOGENOM" id="CLU_2366081_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="95" mass="11051" checksum="5EDC5C1A9AA232C8" modified="2012-06-13" version="1">MFLAFILAIIFQPSGQKYEKIFLTIITLLGILFILLNYIFIFSFPENIKIYPLFIIETHGGYSVISLDFGQIVAVVVIIYLLLYFLIKKKNRVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Q9</accession>
    <name>I0A2Q9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1278"/>
    <dbReference type="EnsemblBacteria" id="AFH43266">
        <property type="protein sequence ID" value="AFH43266"/>
        <property type="gene ID" value="FFONT_1278"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1278"/>
    <dbReference type="eggNOG" id="arCOG00201">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_2"/>
    <dbReference type="OMA" id="TSHDPML"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="19"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="51"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="275" mass="31644" checksum="D8DDEEDBD6360B60" modified="2012-06-13" version="1">MEKAENIILKKEQTFEKYLLVEKIRFSYNSENIFENLSFSLPKKGLMQVVGPNGAGKTTLFKLLLGLYNPKEGKIIVNGEDITGNPRLASKYFSYVPQLIISSKSLNFPISAREFLEWELAFEERWPRFKINNNITNRIKNTLKFVRLEETAFEKDMRELSGGQKQKVFIAKALLKDKPVMLLDEPFSSIDPATRIDLAEIIVKLSREKLVIITSHDPNLLMKNTNYMLLLSRNYYTFGKPENVYKIDVLRNIYGGTAIEVGDKHLHICDEGCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2R0</accession>
    <name>I0A2R0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic solute binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1279"/>
    <dbReference type="EnsemblBacteria" id="AFH43267">
        <property type="protein sequence ID" value="AFH43267"/>
        <property type="gene ID" value="FFONT_1279"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1279"/>
    <dbReference type="eggNOG" id="arCOG01005">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067263_0_0_2"/>
    <dbReference type="OMA" id="YLPERWY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="370" mass="41635" checksum="8870142D02BC8CCB" modified="2012-06-13" version="1">MIKFINFVHVKKFFAQVRKMKRILFFITLVFLFVGFSLSIPNTALAETQNQTQGFIVTTFPSLVDDVKLITGNYFTVVSIVPPGVDPHDYSLTPQDVDILKNATLIISTLHTPMEVQIDNYFKSGLLHSYYIAIPNITGIVFVDNPNNGLPDPHMPIYDPNNYLKFLYNLTLTVSEIDPSHKQYYMQNYENISNQVESLIEKYEGKYRGTAVASTPEAVYAINWLGFNVTRLLLTEEEASVSPQDVNTITSMIENGTANAVAILVSFPPQNGSVSPYSQYDSSLYNIYTTYKKGFLLEVPSPVTGGSILSKLQFIVAQLSSYNNTSNYTSNSSISESTASSYVYIVIAIILIVLITVLLYYWRSRRQNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2R4</accession>
    <name>I0A2R4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Component HyfD of membrane-bound [Ni,Fe]-hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        </source>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
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                <person name="Bidzhieva S.Kh."/>
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                <person name="Ravin N.V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    <accession>H9ZZA0</accession>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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        <property type="entry name" value="SDR_fam"/>
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        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="65" mass="6659" checksum="9365C16DE7BA2A4E" modified="2012-06-13" version="1">MSLKNKISLVTGGGSGIGKAIAEKLSSMGSTVIIFDVSEQSGSSVAKQINDEGGNAHFFKVDVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZD0</accession>
    <name>H9ZZD0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="12">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">kdpB</name>
        <name evidence="13" type="ordered locus">FFONT_0094</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="14" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="12"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0094"/>
    <dbReference type="EnsemblBacteria" id="AFH42087">
        <property type="protein sequence ID" value="AFH42087"/>
        <property type="gene ID" value="FFONT_0094"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0094"/>
    <dbReference type="eggNOG" id="arCOG01577">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025728_2_0_2"/>
    <dbReference type="OMA" id="ILWLWFT"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="605"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="674"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="536"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AFH42087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="704" mass="76919" checksum="2DA90CF8467A7992" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZD6</accession>
    <name>H9ZZD6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0100"/>
    <dbReference type="EnsemblBacteria" id="AFH42093">
        <property type="protein sequence ID" value="AFH42093"/>
        <property type="gene ID" value="FFONT_0100"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0100"/>
    <dbReference type="HOGENOM" id="CLU_1346367_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="203" mass="22170" checksum="3559F2658B503268" modified="2012-06-13" version="1">MLNRKGGSLARVGMKLTPALLIYVSIVLIRAANASFIVSLVAAFHSISAYMQGIIQASYSLTEAIFGIFAGIIYEYLGSFRSILLSSSLLFASYAAMVVFSSIEVGPQAFAVPSALAGLSASFLLTSSFAVISEETTYARNPFGLRTLRPKYMKKAYMLGLPHMISPNDFLSDLDQPRIRLPAVELRLNEVLHYREQKFSGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZD8</accession>
    <name>H9ZZD8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0102"/>
    <dbReference type="EnsemblBacteria" id="AFH42095">
        <property type="protein sequence ID" value="AFH42095"/>
        <property type="gene ID" value="FFONT_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0102"/>
    <dbReference type="HOGENOM" id="CLU_2597544_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="79" mass="8688" checksum="13E1E007993831B7" modified="2012-06-13" version="1">MMGMGFPELIAYIWEREWNALTSHFSSVPQGLLAFLISVSLATLSVLLCRLIRKLAYASLIALWGIALISLLIIGAIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZE6</accession>
    <name>H9ZZE6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0111"/>
    <dbReference type="EnsemblBacteria" id="AFH42103">
        <property type="protein sequence ID" value="AFH42103"/>
        <property type="gene ID" value="FFONT_0111"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0111"/>
    <dbReference type="eggNOG" id="arCOG01292">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_3_2"/>
    <dbReference type="OMA" id="DRANMPG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="335" mass="36703" checksum="C3C483AD45E372AE" modified="2012-06-13" version="1">MKFLKCKAEEIAKEKNKIVSIIGGGPAGLSAAGYLVCKGYEIHVYDVHPELGGLMMFGIPEERLKKDGIRNGVKELISTGMVRAHLKTMVGEKVPLKEIIRSSDATLISTGTLKTKRMNVRCENAENVYPSVEWLIDYHLEKFGYQKLFNIRTYVKEPVGVIGAGFTAADAAFISSTAFKAKTFIFYRRTKKDAPMGANDIKMLEERGVLFYELLSPREVLCKNGVAEGMSFYVTEMRGSGRSAELIVHEDKVQTYYLNTIINAIGPIPTPPIDVGEAGIKLNSNGTIAANEKFETSVKGVFAAGDVKHGPSQIGPAVKSGLDAALKIEEFLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZG2</accession>
    <name>H9ZZG2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-strand DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0127"/>
    <dbReference type="EnsemblBacteria" id="AFH42119">
        <property type="protein sequence ID" value="AFH42119"/>
        <property type="gene ID" value="FFONT_0127"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0127"/>
    <dbReference type="eggNOG" id="arCOG01510">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110881_2_0_2"/>
    <dbReference type="OMA" id="AWTTSYR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="2">
        <location>
            <begin position="26"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="156" mass="17341" checksum="45AFB674BA62A227" modified="2012-06-13" version="1">MSEEKDMGEEPQNKKIMDLKQGESSVSIKARVLETGDTKTIETKKGTRTISEAILGDDTGRIKATFWGDKAGSVQEGQAVEVKGAWTTSFRGKVQLNVGSSSEVSQIDDSEVPQKDEVPESEPTAPMEDRGYGSRRQGGGRRDYRQGRNYPRKREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZI0</accession>
    <name>H9ZZI0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative transcription regulator, encoded next to RecA superfamily ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0145"/>
    <dbReference type="EnsemblBacteria" id="AFH42137">
        <property type="protein sequence ID" value="AFH42137"/>
        <property type="gene ID" value="FFONT_0145"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0145"/>
    <dbReference type="eggNOG" id="arCOG00921">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109226_0_0_2"/>
    <dbReference type="OMA" id="TRVTWVD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022285">
        <property type="entry name" value="CHP03879_regulat_dom_put"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03879">
        <property type="entry name" value="near_KaiC_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="164" mass="18690" checksum="32A55248F8E202A0" modified="2012-06-13" version="1">MNEFFKCKKYIEKNNYNLFGERMSEVPLKPVGKEEIRKLELALIIATLFREDVLQQALETKDKLTWLDSLIVAAGALARERAGIPASRIAEELERTEATIRNHLSGKTDAGKMVKETYEQLVKSGGSLSNIVPEILVKSSEEEKCKERLELVKQKIEEIKKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZI5</accession>
    <name>H9ZZI5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative signal transduction protein with CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0150"/>
    <dbReference type="EnsemblBacteria" id="AFH42142">
        <property type="protein sequence ID" value="AFH42142"/>
        <property type="gene ID" value="FFONT_0150"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0150"/>
    <dbReference type="eggNOG" id="arCOG00600">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1109541_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="273" mass="30599" checksum="5F4AEDB168B59409" modified="2012-06-13" version="1">MFCLIRDFIDKKPVVMNWADSLLAVSREMLKRNRNHSIIVDDSGRAWGVVSIRDIAKAIFVEGEEGIEILESGRLGKILESPIKYYASSPIISLNIESSLDDVIDLLVNKNIGFVPVIENNEIMGAIDERNLLKAIPEHIDLSPCEVPAPEPQSVDFDEEILVAVGLMLSTGVKQLLVMKGEEIYGMTSLLKILYYVLSEHSVDLLLKGSRKPVEEMVAYVSENPWQIDCTYSLKEAASLIYFERLGAVLVRINGSVKIISDRDLLKVLLFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZJ5</accession>
    <name>H9ZZJ5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaredoxin-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0160"/>
    <dbReference type="EnsemblBacteria" id="AFH42152">
        <property type="protein sequence ID" value="AFH42152"/>
        <property type="gene ID" value="FFONT_0160"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0160"/>
    <dbReference type="eggNOG" id="arCOG01218">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082677_0_0_2"/>
    <dbReference type="OMA" id="RMAHKFA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011903">
        <property type="entry name" value="Glutaredoxin-like_bact/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02187">
        <property type="entry name" value="GlrX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="4">
        <location>
            <begin position="44"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="4">
        <location>
            <begin position="154"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="237" mass="26693" checksum="80C70FEF303916D0" modified="2012-06-13" version="1">MSSEEETSEFNEEHPMVPGGELDEETLEALEEALRDMASPVIAEIFVKESCYYCQETIKLLSYFREKSPSVNGKKLFDFVVYDKEKDVEKFKQYGISRTPTVTLVEGRIRYTGIPSGEEIRSLVETIIRISQNDSGLEESSKQTIKSINRKVYIEVIITPSCPYCPYAALLANMIAFESYKSGNKSVIADTVEAYENPDIADKYNVMSVPVIAINGEVAFVGLPYEVDFVEKVKELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZL7</accession>
    <name>H9ZZL7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PflX-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0183</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0183"/>
    <dbReference type="EnsemblBacteria" id="AFH42174">
        <property type="protein sequence ID" value="AFH42174"/>
        <property type="gene ID" value="FFONT_0183"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0183"/>
    <dbReference type="eggNOG" id="arCOG00934">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_2"/>
    <dbReference type="OMA" id="GGEPTPN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="153"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="368" mass="43344" checksum="4C5D2C2DDAE41F7C" modified="2012-06-13" version="1">MTNFFYDEFAEGISLNSRIERALSWYYGILRGRYPPKYKIARSLEVDVKLTSLSLQELWSLHEEFEKEFHKLSNDIMKDESIELRDSSNNSYLDLKIEILKRMLTNCEYCERKCGSNRLTDKGKFCKVDYKTYISSYFLHYGEEYPLVPSGTIFYSGCNLRCVYCQNYEISQSFPLKGKVVAPQQLAAIQDKLVKEGAKNINHVGGEPTPYTHAIVESFKYLKTNTPQIWNSNFYMSEKLTILLRDLIDLWLPDFKYWDDSHAIVLSAAPRYREAVIRNLLLIENEGSIILRHLVLPNHVKCCSIPIIEWLSKNMPKDWLVVNIMDQYYPTYRVLSESERWRDLNRKVRKDEYFEVVDYAAKEDLILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZN0</accession>
    <name>H9ZZN0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde ferredoxin oxidoreductase</fullName>
            <ecNumber evidence="4">1.2.7.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FFONT_0196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Bidzhieva S.Kh."/>
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<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
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    <dbReference type="STRING" id="1163730.FFONT_0233"/>
    <dbReference type="EnsemblBacteria" id="AFH42224">
        <property type="protein sequence ID" value="AFH42224"/>
        <property type="gene ID" value="FFONT_0233"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0233"/>
    <dbReference type="HOGENOM" id="CLU_1485840_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="181" mass="20905" checksum="93FA3E080B1DFAD2" modified="2012-06-13" version="1">MLYYGGNFFNKMRKVYSIGILDRPLPKIFGRYGESAELLDREDAVELLNTAKEKSGITTSDAQIVKNMIEALFLPTSLIYSYFKKLSFSEAAETDEFFIMEFMGSQAKPMKFTLLIVYMWFVIPKSENGCRKSVELMRKIKQEVGTPPISKEEWEELKPLIEKFSRALPIQGSSKNLWDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZV0</accession>
    <name>H9ZZV0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0267"/>
    <dbReference type="EnsemblBacteria" id="AFH42257">
        <property type="protein sequence ID" value="AFH42257"/>
        <property type="gene ID" value="FFONT_0267"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0267"/>
    <dbReference type="eggNOG" id="arCOG02942">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095977_0_0_2"/>
    <dbReference type="OMA" id="CEPVNPG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13456">
        <property type="entry name" value="RVT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="144" mass="16897" checksum="8DA320C4823977DB" modified="2012-06-13" version="1">MRCSKITIKVFFDGLYVKKDEEGIGTYAFVIYRNKEKIYEEMGKVSRKEGRVTNNAAEYIALEKALRWIIERGLNDEKVIILGDSQLVIRQLNGEYKIKSENLYPLFLQIKNLLNKFKDVEISWIPREENQEADFLTKKALSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZV9</accession>
    <name>H9ZZV9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0276</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0276"/>
    <dbReference type="EnsemblBacteria" id="AFH42266">
        <property type="protein sequence ID" value="AFH42266"/>
        <property type="gene ID" value="FFONT_0276"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0276"/>
    <dbReference type="eggNOG" id="arCOG00202">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_2"/>
    <dbReference type="OMA" id="MFQETEL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="240" mass="26950" checksum="0D2F701CD3D5B9C3" modified="2012-06-13" version="1">MSNKLLKVSNLTVEFFKKVALEDITLELPPGVHAILGPNSSGKSTLLKAIASLIPIKKGEVIYDGISISKLPPKKRAQIVGYCWQNPYQGFFEDSVKREIEFILKNTNAKASEEVLEILGVNKLYEKNPFRLSGGEARRVSIASIVVADQPIILLDEPFNDMDLDGYLSIVNLLSFFRKRNKTVIIALNNSMHLNLVKPDDVFVIYSGRIVEKTTLRELNDDVLEKYNIVTRKLILESAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZW6</accession>
    <name>H9ZZW6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="5">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aspartate transcarbamylase</fullName>
            <shortName evidence="5">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrB</name>
        <name evidence="9" type="ordered locus">FFONT_0283</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterooligomer of catalytic and regulatory chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0283"/>
    <dbReference type="EnsemblBacteria" id="AFH42273">
        <property type="protein sequence ID" value="AFH42273"/>
        <property type="gene ID" value="FFONT_0283"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0283"/>
    <dbReference type="eggNOG" id="arCOG00911">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_1_2_2"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="OTCace_N" evidence="8">
        <location>
            <begin position="18"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="OTCace" evidence="7">
        <location>
            <begin position="164"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="319" mass="36349" checksum="C0752836B5EDDEE7" modified="2012-06-13" version="1">MKCLSKGVMINKDFYNQDVISIQQFTREDLETLFEYADRAKKHKDKKLELLKDKVVMLAFFEPSTRTRFSFEVAAKRLGADVVGFSGEEGTSISKGENFTDTIRMLDSYSNLIVIRHKLEGAAKYASEIAENPVINAGDGKQHHPTQAMIDLYTIREIFGTIDELTYAVVGDLRYGRASTSFIYGLLIYNPKKLYLVSPPNLGAREEVISYLKEKGVAFEEIRNLEEIIDEIDVLYTIRLQKERFPDITEYEKAKGSYKITLDLLKNAKKGLKIMHPLPKLDEIDKEIDSTEYAAYFQQAKNGVPVRMALLSLIFGVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZY0</accession>
    <name>H9ZZY0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FOG CBS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0297"/>
    <dbReference type="EnsemblBacteria" id="AFH42287">
        <property type="protein sequence ID" value="AFH42287"/>
        <property type="gene ID" value="FFONT_0297"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0297"/>
    <dbReference type="eggNOG" id="arCOG00602">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076812_4_0_2"/>
    <dbReference type="OMA" id="RQLMRDY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="78"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="143"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="214"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="271" mass="30826" checksum="1E5F8F63D0FCEA64" modified="2012-06-13" version="1">MISIPVGKVKAENILKKFPYLLPYDKASHARELIREYKIRVLAVANSPNNPKIVGLIKRVNILNISSTKSNLQVNDIMEQPIAIIREDDEVDVILNALLKNNEWYGIVTNSSGEYKGIVGLEDVINYYYKNEPEIFNVEASVLSKKLEYLYEDDEISKAWYKMLEHDYAGFPVVKRDLKVVGSLTQHDLISKGYTRIQLESQTSPRKILVKEAMNVPPICIKQSDKVTNAVDEMVNKNVGRVFIIDDGGKIKGIIDRSDIARLIFEKKIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZZ5</accession>
    <name>H9ZZZ5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclopropane fatty acid synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0312</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0312"/>
    <dbReference type="EnsemblBacteria" id="AFH42302">
        <property type="protein sequence ID" value="AFH42302"/>
        <property type="gene ID" value="FFONT_0312"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0312"/>
    <dbReference type="eggNOG" id="arCOG01631">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068443_2_1_2"/>
    <dbReference type="OMA" id="RVVSFCW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026170">
        <property type="entry name" value="FAM173A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13610">
        <property type="entry name" value="PTHR13610"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="4">
        <location>
            <begin position="41"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="185" mass="21436" checksum="7665308AD18BB6FF" modified="2012-06-13" version="1">MREDIPIWPKEEKVDAPWIPSSIKPIIFSFEIAKLNKDSKICDIGCGDGRVAIIASKYFGCSSTCIEKREDLCALALSNAIYNSVNDKFSVICEDARKIDYSEFDFIYIYMFPSFLREISLKLDKELKEGTKIVTLDFSIEGWIPILMKRIEDEKGIIRSIFLYFIGISNPSAWRIRRFYGYPRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A017</accession>
    <name>I0A017_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytidine deaminase</fullName>
            <ecNumber evidence="5">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">FFONT_0334</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine + H(+) + H2O = NH4(+) + uridine</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0334"/>
    <dbReference type="EnsemblBacteria" id="AFH42324">
        <property type="protein sequence ID" value="AFH42324"/>
        <property type="gene ID" value="FFONT_0334"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0334"/>
    <dbReference type="eggNOG" id="arCOG04173">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097262_4_1_2"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH42324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="139" mass="15445" checksum="93C6C7663CFFB32B" modified="2012-06-13" version="1">MKAISEKINLEKLLAIAKDIIKNSYSPYSHFPVAAVVKTKKGNIYTGVNIENASYGLSICAERVAIFKAVSEGDREIEILLVYTPTKQHIYPCGACRQVILEFNPNALVIIANKDGIFKSARIKDLLPMSFSKRSLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>I0A031</accession>
    <name>I0A031_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0348"/>
    <dbReference type="EnsemblBacteria" id="AFH42338">
        <property type="protein sequence ID" value="AFH42338"/>
        <property type="gene ID" value="FFONT_0348"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0348"/>
    <dbReference type="HOGENOM" id="CLU_3162951_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="47" mass="5680" checksum="A57EF60F989FCBFF" modified="2012-06-13" version="1">MNSRVELLCEGKRALPESSDKKIVEFLWMLRDKIYRTLRCFRILLHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A067</accession>
    <name>I0A067_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MAF_flag10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0384"/>
    <dbReference type="EnsemblBacteria" id="AFH42374">
        <property type="protein sequence ID" value="AFH42374"/>
        <property type="gene ID" value="FFONT_0384"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0384"/>
    <dbReference type="eggNOG" id="arCOG04303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093043_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027510">
        <property type="entry name" value="HMPDK_MptE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39648">
        <property type="entry name" value="PTHR39648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="SSF63999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MAF_flag10" evidence="5">
        <location>
            <begin position="14"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="212" mass="24796" checksum="8A79E44B45628E4B" modified="2012-06-13" version="1">MLDYPRISLEEIYSSVEGKKVIVIAGSKCYEDYINCKNPNEAIIFVADKGIKCLSRNDIKPTAIITDLDGINDNILFHPKYKNSYFFIHAHGDNQELIKKYLPSIMKQKIKIIGTTQTKPFYPLFNFGGFTDGDRTVFTALFFKAKEIEIYGIGEEYFNIDVFYNLNKLDIKAKKFLAGYLIINWLKCKWKYRISIPYENDEKCLEIYPWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A076</accession>
    <name>I0A076_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="ordered locus">FFONT_0393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0393"/>
    <dbReference type="EnsemblBacteria" id="AFH42383">
        <property type="protein sequence ID" value="AFH42383"/>
        <property type="gene ID" value="FFONT_0393"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0393"/>
    <dbReference type="eggNOG" id="arCOG01303">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_2_2"/>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="137" mass="15730" checksum="D9127344F5E4E494" modified="2012-06-13" version="1">MTEIVKIKDYNVRKDFYYTETDEWIKLEGMNARIGITDYAQKHLKDIIGIDLPEKGKKIKKGEVLATLDSIKATSEVYAPISGEILDVNETLLESPELMNSDPYESGWIALIKIENNDELNSLLTFEQYVKLLESRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
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        <name evidence="4" type="ordered locus">FFONT_0395</name>
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    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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            <taxon>Archaea</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
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    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="39"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="142" mass="16887" checksum="78AF0E0F4447C043" modified="2012-06-13" version="1">MYWYDDFERIREYIRKRIKEMEREFEDAFLSTSLPIEEFTAEDISSPLYTIYESEDSYYVVIDAPYMDTSSLTIEAHDNILNIEVKLKEKINLGNIGYRLHSCEIFNYRKTISLPPDADVSRLTYSIKSGRIIINIPKKHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A097</accession>
    <name>I0A097_FERFK</name>
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        <submittedName>
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SAM-dep_methyl-trfase"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA_3" evidence="5">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
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        <location>
            <begin position="173"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF10672"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF17785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="397" mass="45590" checksum="DA77C8CC7FFE1A1F" modified="2012-06-13" version="1">MKNMKTVEIKKGAKSLIEKHFYSIYSKWVKSDSSLSNGDFVKFLFNGEVIGYGFYEKIGSIGGRIISYISEYDNPDLNELIRWRVNQGYLIRKKIGEKKERGYRLLYGDCDGTPGLITDVFNDTSVIQTTSYGWDRNLSLLADAIVKAGISERVFLKNDQRGRKFFGLPIEKKFLHGEPPPYTYIKEDDLIFKIDFLNGQKTGFYLDQREARKKISSLSLDGAKILDLFSYTGSFSAHALKAGASFSLLVDEDDRALNIAKENLIKNGFEDKFEIIRGRVEKVIDSLLIKKMQFDIVIVDPPAFIPSKNLYEKGIKAYKKLFGNTLRLVKLGGYIYASSCSFHLSSDELLKILQEWINYYGYKSRVIYELSPFNVFPFTRPLDVELRYLKGFLLELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0B9</accession>
    <name>I0A0B9_FERFK</name>
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        <submittedName>
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                <person name="Kublanov I.V."/>
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                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0436"/>
    <dbReference type="EnsemblBacteria" id="AFH42426">
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        <property type="gene ID" value="FFONT_0436"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0436"/>
    <dbReference type="HOGENOM" id="CLU_2856947_0_0_2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="64" mass="7720" checksum="A32D0B20FC3402D9" modified="2012-06-13" version="1">MFLSDIFTYINKKAYSQVIDYFTTENLLTYEQKLKKIINFYTIHSNVVLVIINKRILIIFQNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0E0</accession>
    <name>I0A0E0_FERFK</name>
    <protein>
        <submittedName>
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        <lineage>
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0457"/>
    <dbReference type="EnsemblBacteria" id="AFH42447">
        <property type="protein sequence ID" value="AFH42447"/>
        <property type="gene ID" value="FFONT_0457"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="256" mass="28906" checksum="1D9E89FC9FB205D5" modified="2012-06-13" version="1">MEILSKIPLTLGVLIPKRNTPFLAYLTDSYLEISYKIKQSSEFSIEIRGLDERIAKASMEHVSYLIKKGSPLPLKVDIEARGIGNCSNLPSAVALILKGVILSLEEYYEEKFSNDEKIEILNGVMNSVGIFPEEILQSLIRATVREKSLIYSDTDGEIFLEDLKVRCNGIKEKGSISVEKEIDSGLLDMYSKLNSYLLILNVNGIVEKNKEKFEQSIRGLNSLYYAIYDVLPEKENLIVPSYKNELLSVEIKNAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-04-07" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0J8</accession>
    <name>I0A0J8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpl22</name>
        <name evidence="8" type="ordered locus">FFONT_0515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="4 6">This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 6">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0515"/>
    <dbReference type="EnsemblBacteria" id="AFH42505">
        <property type="protein sequence ID" value="AFH42505"/>
        <property type="gene ID" value="FFONT_0515"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0515"/>
    <dbReference type="eggNOG" id="arCOG04098">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_0_2_2"/>
    <dbReference type="OMA" id="ANAEYKG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_A">
        <property type="entry name" value="Ribosomal_L22_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_L22/L17_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="PTHR11593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="156" mass="17888" checksum="D2CCBFD753F998CC" modified="2012-06-13" version="1">MGGWNYSLKLEDESKIAKAVMRDLPISPKKVHNLARAVNGMMLQDAKKYLERVIAKEEAVPHFIHRKKIPHHKGLSERWGIPVGKYPVKAAKFLLKALNNVEANAESKELDAEKLKIIHLSVQQGYTLKRYMPRAFGRSTPKFKRYSNIEVIVKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0K2</accession>
    <name>I0A0K2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0519</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0519"/>
    <dbReference type="EnsemblBacteria" id="AFH42509">
        <property type="protein sequence ID" value="AFH42509"/>
        <property type="gene ID" value="FFONT_0519"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0519"/>
    <dbReference type="eggNOG" id="arCOG06081">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2433666_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="80" mass="9638" checksum="AFBA00F96A4F9787" modified="2012-06-13" version="1">MKAYRIFYTTFYDDDHENVKKKLNELIGIEALDHKSFVKEFRYLEYRSESLKPGLEEEIRRIAEEVLGKKSYIKVDFISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0L0</accession>
    <name>I0A0L0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DEAD/DEAH box helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0527"/>
    <dbReference type="EnsemblBacteria" id="AFH42517">
        <property type="protein sequence ID" value="AFH42517"/>
        <property type="gene ID" value="FFONT_0527"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0527"/>
    <dbReference type="eggNOG" id="arCOG00557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="OMA" id="LCLNCGW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013701">
        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="Lhr_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="51"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="255"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
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                <person name="Mardanov A.V."/>
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</entry>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="240" mass="27385" checksum="17DCFF70A1558D2E" modified="2012-06-13" version="1">MEHRKIKPSMLFIYAIAVSIMAFVFNLPSSLLIPSLLNFILGICYGRKTLPMKLIFVILMINAWGALINGIYFHNTGPMLFKIGGLSVRYNALTSFLLVNLRFFLIIGSTLFMLGMSGGSRELIRSLERDLGMPPWIAFSISHAFRLFPLISRDYRELQIARKERKAGTNILNPLILKEVLISILNVSYERAQWSGISAELRGVKLRKRIKKEKLSIYDIFILSLIAVEWAIAIIFVKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0R4</accession>
    <name>I0A0R4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0581"/>
    <dbReference type="EnsemblBacteria" id="AFH42571">
        <property type="protein sequence ID" value="AFH42571"/>
        <property type="gene ID" value="FFONT_0581"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0581"/>
    <dbReference type="eggNOG" id="arCOG00185">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_86_7_2"/>
    <dbReference type="OMA" id="MYRGEQV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="263"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="296"/>
            <end position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="482" mass="54431" checksum="8C6C71909F2ADD64" modified="2012-06-13" version="1">MLSVRINSAGYNESEKILNNISFDAESGKLILIGGHSGSGKTTLLFAITGVLTSLLKGWADGKVIYRSTDILKLDEPLSFSGKIFGFVLQDPDRQLLMPTPFDEVMFTLENFGFEESEAKKKTENLLETFGLKKKMFEHVENLSGGEKRRLSLASAIAHDPPIIIFDEPTASLDPWGINDVRNFIASEIRMGKSIIVVEHKVKYFIDMASELIVLGKNSDTTYFKDITISPEFLEKLDSLGVDSYPVSETKKKKDENRREKILEMRGVECWYDESDYILRNIDLDLRRGEVVALVGPNGSGKTTLLKTIAGFHKKYSGEIKIYAERKNVKPFYVPQVPDYLFIKNTLKEELEFLSKKTGKRKDELIALLDFYESRKNSSPYTLSLGQRRWLSAVIAWSYEPSIVLFDEPTVGLDKFMLFDFFSNVIKLKEKGTSFLISTHDPRVLSEIADRAYATYNGSIKEVDPIDEAKKLETISGVSHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0U4</accession>
    <name>I0A0U4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SirA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0611"/>
    <dbReference type="EnsemblBacteria" id="AFH42601">
        <property type="protein sequence ID" value="AFH42601"/>
        <property type="gene ID" value="FFONT_0611"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0611"/>
    <dbReference type="eggNOG" id="arCOG02062">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_1_2_2"/>
    <dbReference type="OMA" id="CPGPLMD"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="1">
        <location>
            <begin position="5"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="78" mass="8434" checksum="6E43BFDE90F01706" modified="2012-06-13" version="1">MGEKKVVDARGMACPGPISKLTRAYREAKNGDIIEALATDKGFIEDVKAWCQSTGNKLLELKVEGDVIRATIEVAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0W2</accession>
    <name>I0A0W2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, family 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0629"/>
    <dbReference type="EnsemblBacteria" id="AFH42619">
        <property type="protein sequence ID" value="AFH42619"/>
        <property type="gene ID" value="FFONT_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0629"/>
    <dbReference type="eggNOG" id="arCOG01389">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062567_0_0_2"/>
    <dbReference type="OMA" id="WRIRRAQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="46"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="367" mass="41752" checksum="9B4067F0BCB94AB5" modified="2012-06-13" version="1">MLEYIGLGLALIHFGTPLSYYVYMKKKYFGKPWDMKREEGFKPKITVIVPTYNEAKLIEKKLDDIYAQEYPRDRLEVILIDSASSDGTLEIAEKWKEEHGEINLKIIGEDSRRGKAHSLNEALKHSTGEIVVITDADSFWGTRDSLGRAAEWFSDPSVGAVSCLKDPEGSEAPSIELGYRGYYNVLRVAESKAYSTPIFHGELASFRKDLLEEVGEFPVDIGSDDSHTATKIAAMGYRAIIPEDVLCKELVPKRGYNSWRIRRAQHLVQHFMKAMKLKVKAPKNFDRILKVEEYLHLMNPWILLGGAVLLSASAIMGSLISLIFLALGIALLMYKPYRTWISMQLYLVIAAIKNLWSREIVWEKQEK</sequence>
</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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    <sequence length="159" mass="17684" checksum="DB6F9103090F6140" modified="2012-06-13" version="1">MPLLLLIVVKGFQNKGKSRHIVVRLFSIIIMVVVLLNFFANIYSSTKYSHPRIFGIENIRPLTKFICSNSGSHIQIAASDAYYAAFLTYFCVTSNSMFITVPLGKNAISLKLALHNVSMLTDFIIHNLKEGGITYLVYVDDGYPPIWGCLGVCGIFISV</sequence>
</entry>
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                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42635">
        <property type="protein sequence ID" value="AFH42635"/>
        <property type="gene ID" value="FFONT_0645"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0645"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="44" mass="4725" checksum="72B98781E84A54C9" modified="2012-06-13" version="1">MSLRGSCTFYLNMPVVNAGRSVDDVVQEVCEKLGLGIVKTSHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0Y6</accession>
    <name>I0A0Y6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
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        <lineage>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
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        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH42643">
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <source>
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        <source>
            <dbReference type="RuleBase" id="RU363032"/>
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    </evidence>
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            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="307" mass="34122" checksum="BF47A5378DD28558" modified="2012-06-13" version="1">MQRPPKHDKLFFLSLLPFASILIAIFMFLFYFLYEKSIPILSSEGMKFLIGSVWNPEMNEYQIFPMLLGTLETAAIALLISIPLSLAAVAFLNEYVPSGRVAKWITLIFELFAGMPSIIFGIWGAQYLAGALKDSLMVPLHNYFGFIPLFSCSPMSGFTLFTASILLSLMITPYMFSMLNSSYNSIPSHIREAAYSIGLRKYQVFRILLSYMKPGTYASLLLGFGKAAGETVAVSLVIGNINVASYCLFSPGMTISSLIASQFPESYLYPNMLSALYAGGLILLIIGMVFNYLGFVQTKKFRARLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>I0A111</accession>
    <name>I0A111_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ordered locus">FFONT_0680</name>
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    <organism evidence="1 2">
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    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
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                <person name="Bidzhieva S.Kh."/>
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                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42735">
        <property type="protein sequence ID" value="AFH42735"/>
        <property type="gene ID" value="FFONT_0747"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0747"/>
    <dbReference type="HOGENOM" id="CLU_1922693_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="131" mass="14366" checksum="84485E0455FEDB5D" modified="2012-06-13" version="1">MLLPLILASLILASIIYASQATGNLSTIVQNTTFNSENLFVLCYSVNSDSIAIQIKNEDNKESVETFDVIFINTRNETIATLNGINLTLSPGETKVIQISNVPFSLNQNVVFPKVVEISSNEYEIQVPVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A190</accession>
    <name>I0A190_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0759"/>
    <dbReference type="EnsemblBacteria" id="AFH42747">
        <property type="protein sequence ID" value="AFH42747"/>
        <property type="gene ID" value="FFONT_0759"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0759"/>
    <dbReference type="eggNOG" id="arCOG00972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108783_0_0_2"/>
    <dbReference type="OMA" id="NSVWVSH"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02166">
        <property type="entry name" value="NMNAT_Archaea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01527">
        <property type="entry name" value="arch_NMN_Atrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="182" mass="21231" checksum="B3DC8C2CC10B4E1A" modified="2012-06-13" version="1">MFEEIKERYNRILFPGRFQPLHYGHIEVIKWMLNFGDEIIIAIGSAQKSHMVDNPFTAGERMVMIREALKEEGFDLSKFYIVPVPDIEYNSIWISYLESLLPPFDAVCSRNPLVIRLAKEERYDVLVPPFFLRSEYSGKKIRKKMLSGEKWESYVPPSVARIIKQISGIQRLIDSSLSDELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1A2</accession>
    <name>I0A1A2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FFONT_0771</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0771"/>
    <dbReference type="EnsemblBacteria" id="AFH42759">
        <property type="protein sequence ID" value="AFH42759"/>
        <property type="gene ID" value="FFONT_0771"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0771"/>
    <dbReference type="eggNOG" id="arCOG00405">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015515_2_1_2"/>
    <dbReference type="OMA" id="EPSYGID"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="PTHR10745"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="8">
        <location>
            <begin position="5"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="547"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="575" mass="66438" checksum="62564D0EABDF9597" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1A6</accession>
    <name>I0A1A6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA-splicing endonuclease subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0775</name>
    </gene>
    <organism evidence="5 6">
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        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42763">
        <property type="protein sequence ID" value="AFH42763"/>
        <property type="gene ID" value="FFONT_0775"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0775"/>
    <dbReference type="eggNOG" id="arCOG01701">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114393_0_0_2"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
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            <end position="55"/>
        </location>
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        <location>
            <begin position="65"/>
            <end position="142"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="156" mass="18261" checksum="50EDB17A3164CDA4" modified="2012-06-13" version="1">MDGFYGKPFGIKKPERREYNEVLELSLVEALYLVEKGKLSVLNSEGKEMSFDELLNEAYNRIKSFKSLYIIYRDLREKGYVVRSGLKFGSDYSLYRHGPGIEHAPYLIHVYEGDEIIDPIELVRMGRLSHSVKKKFMLGIVRNGIPNYILFKWYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SSF53686"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="379" mass="42801" checksum="E833252CE89413CC" modified="2012-06-13" version="1">MIALLKGLKTICPSNNEEYDGIVLSDSRCDSPLMIEIGGAEWKVLHDVPSIWRYSNLMPKFSETVTRGEGFTPLRRWSEKDIYLKLEGFNPTGTYMDRGSSVLASFFKTYKPNDSAIIRYSKDFAISAATYLTPSHRTKVVIEDPLKADPEELTSLVYLNAELCTERYREAISYDNPLTIEGLKTIIFEIVERGITEGKILVPSESGVLALSIWKGIKDLEKANFETNFKIIAAVLEDNYPSYLKNIEGIQIEKIKLNELIDNFIELTRKGVKVKLVSALGVALAMKLGEGIVIVTGESKGVNLRGSQSFWNDIKKDIAKALEGKKGMTAYEIWRELKEKYTLRGIYKALESLEAEGIVISFFEMRKNKKVRKYSLFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1C0</accession>
    <name>I0A1C0_FERFK</name>
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        <submittedName>
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        <lineage>
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    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
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        <property type="protein sequence ID" value="AFH42777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0789"/>
    <dbReference type="EnsemblBacteria" id="AFH42777">
        <property type="protein sequence ID" value="AFH42777"/>
        <property type="gene ID" value="FFONT_0789"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0789"/>
    <dbReference type="eggNOG" id="arCOG01888">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="M29_N-terminal"/>
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        <property type="entry name" value="Peptidase_M29"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="371" mass="41941" checksum="E048EB2EA419116C" modified="2012-06-13" version="1">MSQLSSIEEKFALLLVDYCIGVKRLSEIQVSGTINAMPLINELFKKIVDRGGYPRIVITNEELSEYFYRYASKELLEYVSPIDKYVMENINGLIRILAPSHSKHLIGVDPERIKIATLAGKVISDIMLKRDAMGTLKWTITVYPTNAMAQEAGFSPIEWKNFVYSALKLYSSDPIEEWKKQALMQEKITKLLNKVDELLVLSDDTELFMKFAGRTWISDDGKNNMPGGEVFSAPIEDSIEGYITFTYPAIWKGVEVENVKLKFKSGTIIEANASKGEDFLKKMISTDEGSKRVGEFAFGLNYDITRFTKEILFDEKIGGTIHMALGAAYLQTGGKNTSSIHWDIVKDMRKGIIKADKEKIYENGRFIESVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1C3</accession>
    <name>I0A1C3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="protein sequence ID" value="AFH42853"/>
        <property type="gene ID" value="FFONT_0865"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0865"/>
    <dbReference type="eggNOG" id="arCOG05989">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="OMA" id="HNISKEC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="126" mass="14684" checksum="087224C8EC4A9778" modified="2012-06-13" version="1">MSAITFFRKLDRETRKKIIETIVLKRGGKKVAEDLGVSKAAISRYLKGEIFPSDKILSKIFEISDKEEREKISIIIGEYIVDLLKEYKNLFSSLEKDTIYKDIKMKIFEELESLVKELKSECDQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1L5</accession>
    <name>I0A1L5_FERFK</name>
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        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0884</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0884"/>
    <dbReference type="EnsemblBacteria" id="AFH42872">
        <property type="protein sequence ID" value="AFH42872"/>
        <property type="gene ID" value="FFONT_0884"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0884"/>
    <dbReference type="eggNOG" id="arCOG01054">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="LGYEMPC"/>
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    </dbReference>
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        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
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        <property type="project" value="UniProt"/>
    </dbReference>
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        <property type="entry name" value="DH_E1"/>
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        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <feature type="domain" description="E1_dh" evidence="5">
        <location>
            <begin position="17"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="335" mass="37820" checksum="836F51605165922A" modified="2012-06-13" version="1">MLLSEIPKEKILWMYKTMLLIRKNEEAVEKYYRIGKIPGSLHLYIGEEAVAVGVVANLNREDVITSTHRGHGHFLAKGGSLKKLWAELLGKRTGACKGKGGSMHLFDFENCNLGSNGIVGGGIPHAVGAALSFKLSESKNVAVSFFGEGATNQQNFHEGLNLASIWKLPVIFVCENNQYQISLHYSKQQAIEGVAKRGISYGIPAVEVDGQDVVAVYEVVKRAVERARSREGPTLIEAKTYRFTGHTIDDNELYRNRDEVEWWKKNKDPLAIFERKIIEEKIFGKEVLEKIAEDVEKEIEETIKFAEESPYPEPEELFEDLYSTKTKGTLIWNWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1M7</accession>
    <name>I0A1M7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0896"/>
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        <property type="protein sequence ID" value="AFH42884"/>
        <property type="gene ID" value="FFONT_0896"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="248" mass="28871" checksum="06DA97E3959EF622" modified="2012-06-13" version="1">MKIKGVILAGGEGKRLWPISYYIQKTMIPLGPEEKPLLEFIIRLLKLNGINDIVILIGYKGNQIKNYFGNGERFNVNIDYSEDDENYKGSAGALLKAYINGLFNDTENVLIYYGDILGDFNLKEMMMFHSSRNADATLMVTEKYNVPVGIAKIENDKIIELKEKPWLELNATIGILTMKTNLISLIKKIHKKETDIMSDFIPFLIKENYLILPYFFKDKWYDIGSIERYEKIDKTWLNSIYQKLFYQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1N0</accession>
    <name>I0A1N0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0899"/>
    <dbReference type="EnsemblBacteria" id="AFH42887">
        <property type="protein sequence ID" value="AFH42887"/>
        <property type="gene ID" value="FFONT_0899"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0899"/>
    <dbReference type="eggNOG" id="arCOG06075">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1418642_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="191" mass="21697" checksum="1F252350DA81CA51" modified="2012-06-13" version="1">MGKMPNAKQLAVIIIGIAFISLMVFAIVVPIFSGFGIQPIVNSEGVYVYYHNKWIKENTNNTAWFPKDNGTYLIYLRNLNCPACQNFDPVWSEYMTNYLLSKNPYNITPVEIVCTYFSSSCTDPSAKATFSFYEQLLGNYFGTPYLVLISNLSFIYYNFPPINNTGYFDASLLNQTISTVLYNYLNKNGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Q2</accession>
    <name>I0A1Q2_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0921"/>
    <dbReference type="EnsemblBacteria" id="AFH42909">
        <property type="protein sequence ID" value="AFH42909"/>
        <property type="gene ID" value="FFONT_0921"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0921"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1048069_0_0_2"/>
    <dbReference type="OMA" id="FTEDICF"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009198">
        <property type="entry name" value="UCP014484_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09973">
        <property type="entry name" value="DUF2208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="251" mass="28563" checksum="40BE24E0A1699CCB" modified="2012-06-13" version="1">MSMPFQSKRQIAIGQASIIIFSIAAGFLGRSGAVYWLFIILYFILYMIIMTKFGQPKLPNTAKADLISKGKVLFEENKAMEVASTDRQYVVEMQDQLKMLQFTTLFSFLVLIYFFIAIGPVTSLIAPKFSNEKIGYSVSYFILFEGSFLLSIFGQYLSVRNYSRSGKKFVTINMPRTFFVTSEGIVLKGMMSSTGLKFPLTAYKIVLNEERKFVELVNETQKAINKIRLYTKSPNKLYEVISNKNSSADEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1R3</accession>
    <name>I0A1R3_FERFK</name>
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        <submittedName>
            <fullName evidence="5">2-oxoacid:ferredoxin oxidoreductase, fused gamma and delta subunits</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0932</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterotetramer of one alpha, one beta, one delta and one gamma chain.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0932"/>
    <dbReference type="EnsemblBacteria" id="AFH42920">
        <property type="protein sequence ID" value="AFH42920"/>
        <property type="gene ID" value="FFONT_0932"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0932"/>
    <dbReference type="eggNOG" id="arCOG01603">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01605">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060916_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
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    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
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        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
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        <property type="entry name" value="PorD_KorD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43724">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02179">
        <property type="entry name" value="PorD_KorD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="322"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="374" mass="42682" checksum="C37A638486E75C69" modified="2012-06-13" version="1">MKFTPKIERYFDYEKLDWIISHGIGVDHTADMTAFSQTLAQVGALKGIETYYYMRYDDSPERNYIPMIFYTVFGNPNVPVLLHEEVEPVGELFNVIAVFSSSLLLQKTSQRALLFDGAKKNAILVVNTSISPDDVVKLVKKYNLAQDWFGRVVTISAARIDSAIAYPMLGAVASAWDRVDLDSLLAAADIFGKEKKKESIRKGYENSSVKEVHILAEETEMFKKIKNEIELPEYTGEFWTPEVYYTYQKAAAEAQTYSSRIASMPRWEVLAPGLIEFGPKPGNKNIGFTTQWRWQRPIIDYKRCTDCKLCHYYCPDGAISFNPIKIDYDYCKGCGICANVCPAKAISMVSELEHLEGLKDREVLRRFDQREYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1S2</accession>
    <name>I0A1S2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0941</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0941"/>
    <dbReference type="EnsemblBacteria" id="AFH42929">
        <property type="protein sequence ID" value="AFH42929"/>
        <property type="gene ID" value="FFONT_0941"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0941"/>
    <dbReference type="eggNOG" id="arCOG02569">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3130689_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="1">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="49" mass="5624" checksum="9EEE16B233E5683A" modified="2012-06-13" version="1">MELKVKDCESTKELVINSDDDANKALNVMLKHRLSSLPVIDKDDNFVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1T2</accession>
    <name>I0A1T2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">V-type ATP synthase beta chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">V-ATPase subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">atpB</name>
        <name evidence="9" type="ordered locus">FFONT_0951</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0951"/>
    <dbReference type="EnsemblBacteria" id="AFH42939">
        <property type="protein sequence ID" value="AFH42939"/>
        <property type="gene ID" value="FFONT_0951"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0951"/>
    <dbReference type="eggNOG" id="arCOG00865">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022916_0_0_2"/>
    <dbReference type="OMA" id="ICELRTP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="PTHR43389"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP-synt_ab_N" evidence="8">
        <location>
            <begin position="21"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-synt_ab" evidence="7">
        <location>
            <begin position="142"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="474" mass="52734" checksum="D77C34A729960DB9" modified="2012-06-13" version="1">MIILESTRRIHGVMESKEIEMIRGPLLFVKVSSGVAFDEVVEVELQDGEKRRGRVLDVSKNLAVIQIFEGTTGIGSLGTTVRFLGETFEVGVSEDMLGRIFDGLGNPIDGGPMVIATEKRDINGDPLNPASRAYPKDFIQTGVSAIDVMNTLVRGQKLPIFSGGGLPHNMLAAQIARQAVVRGEEEEFAVVFAAVGIKYDDFLFFKRFFEESGAKNKVAMFVNLANEPAMIRLITPRVALTLAEYLAYEKDMHILAIITDMTNYAEALREISAAREEIPGRQGYPGYMYSDFASIYERAGRAIGKKGSITQMPILSMPNDDITHPIPDLTGYITEGQIVLDRGLFNKGIYPPINVLMSLSRLMKEGIGPDKTREDHGDVYNQLYAAYSRAQELRSLATIIGEESLSSTDKLYLRFAESFERTFINQSPTENRSIEQSLDLAWSILSILPESELTNIRTELINKYYKKGMEAEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1U2</accession>
    <name>I0A1U2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 15">Fructose-1,6-bisphosphate aldolase/phosphatase</fullName>
            <shortName evidence="15">FBP A/P</shortName>
            <shortName evidence="15">FBP aldolase/phosphatase</shortName>
            <ecNumber evidence="6 15">3.1.3.11</ecNumber>
            <ecNumber evidence="15">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">fbp</name>
        <name evidence="16" type="ordered locus">FFONT_0961</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="17" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 15">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 15">Homooctamer; dimer of tetramers.</text>
    </comment>
    <comment type="domain">
        <text evidence="15">Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the FBP aldolase/phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="6 15"/>
    <dbReference type="EC" id="4.1.2.13" evidence="15"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0961"/>
    <dbReference type="EnsemblBacteria" id="AFH42949">
        <property type="protein sequence ID" value="AFH42949"/>
        <property type="gene ID" value="FFONT_0961"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0961"/>
    <dbReference type="eggNOG" id="arCOG04180">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041630_0_0_2"/>
    <dbReference type="OMA" id="YMRRHGP"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02067">
        <property type="entry name" value="FBP_aldolase_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002803">
        <property type="entry name" value="FBPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036076">
        <property type="entry name" value="FBPase_V_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38341">
        <property type="entry name" value="PTHR38341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01950">
        <property type="entry name" value="FBPase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015647">
        <property type="entry name" value="FBPtase_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111249">
        <property type="entry name" value="SSF111249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 15" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="11 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="FBP binding" evidence="15">
        <location>
            <begin position="107"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="FBP binding; shared with dimeric partner" evidence="15">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for FBP phosphatase activity" evidence="15">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor; for FBP aldolase activity" evidence="15">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DHAP; for FBP aldolase activity" evidence="15">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>dihydroxyacetone phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AFH42949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="366" mass="40529" checksum="095B6C17CF38E03E" modified="2012-06-13" version="1">MSTGKKVTLSIIKADVGGLAGHHVVHPDLIATATRMLSEAKESGIIEDFYVTNVGDDLQLIMTHYRGVDSKDVHSLAWDTFKEATKVAQKLGLYGAGQDLLSDAFSGNVRGMGPGVAEMEFIERTSEPVVAFMADKTEPGAFNLPFYKIYADPFNTAGLVIDPKLHSGFKFEIWDLIEHKQYFLNAPEDSYDILALIGTTGRFTIKRVYRKDNNEIAAAVSSERLNLIAGKYVGKDDPVAIARAQSGFPALGEILEPFSFPHLVAGWMRGSHNGPLMPVSQKDARCTRFDGPPRIIALGFNIKDGKLIGPTDLFDDPAFDETRRTAQIIADYMRRHGPFMPHRLGPEEMEYTTLPQVLKKLEEKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1U4</accession>
    <name>I0A1U4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="1">TMP kinase</shortName>
            <shortName evidence="1">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="1">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiL</name>
        <name evidence="4" type="ordered locus">FFONT_0963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="1"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0963"/>
    <dbReference type="EnsemblBacteria" id="AFH42951">
        <property type="protein sequence ID" value="AFH42951"/>
        <property type="gene ID" value="FFONT_0963"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0963"/>
    <dbReference type="eggNOG" id="arCOG00638">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046964_2_1_2"/>
    <dbReference type="OMA" id="DFGWRNV"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="46"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="196"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="126"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="327" mass="37329" checksum="402D2868F0A65BB2" modified="2012-06-13" version="1">MRSDKLSSVGEIKAIERLLKQYKAFYRKDFCFPIDDDVQAFYNCKISIKIDGYCEKYSRYPWERWSNWGWRAITGTVSDLYAKGYTPFGVVYSLGLPKNFPLSKLEDISIGIKKAMREYDLSFLGGDLNVSYKYAWIDVAALGTHSTSYIFPRSGAKAGDLVFTTLVNGYGTSSLLFFAYKNRLWNKLPREFLNYTPRAVKEFPLVSKAIKVNSSIDSSDGLAKSLWILAKSSNVVIHIDNIPIHGKVISYLKNFNLNIEEFALYGGEEYEVIFTTSEKEDRVIRVCKSAGIECIKIGKVIEKSDKPKIIFNNREIKPEGWDQFLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1U9</accession>
    <name>I0A1U9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFH42956">
        <property type="protein sequence ID" value="AFH42956"/>
        <property type="gene ID" value="FFONT_0968"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0968"/>
    <dbReference type="HOGENOM" id="CLU_3038891_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="54" mass="6799" checksum="B95C7B9D3D9ECDC3" modified="2012-06-13" version="1">MKWLEKYARRTIKNMLKENINEHVGYRYWISIDKKRNLIYVYDKKKGKRYVFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1Z8</accession>
    <name>I0A1Z8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfhydrogenase subunit gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1017</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="4">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1017"/>
    <dbReference type="EnsemblBacteria" id="AFH43005">
        <property type="protein sequence ID" value="AFH43005"/>
        <property type="gene ID" value="FFONT_1017"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1017"/>
    <dbReference type="eggNOG" id="arCOG02199">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_1_2"/>
    <dbReference type="OMA" id="NTARYGK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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                <person name="Ravin N.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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    </dbReference>
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            <dbReference type="EMBL" id="AFH43087.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
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    </evidence>
    <sequence length="213" mass="23955" checksum="55599BCC6C41E7AA" modified="2012-06-13" version="1">MSVLKLIKKKLVLRIPKNADVERFLDAIMGSTIATQVMYRIKGNSVEIRIIGDPVSVENSIHRIRSAVEDFAIKMGYPKEGRGITVFGSMLAKSLEVPVPLEGFKRLLELENIDFSYDEKEDLLVIYDDLEELKSLAKDLFDSYKSAREIARGIGAEIIAVLSVYSGLSPMEIASIGEEEGVFEKIEDMYMLKADKDKALNTIIEALKKKNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A292</accession>
    <name>I0A292_FERFK</name>
    <protein>
        <submittedName>
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    </protein>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
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                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
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        <property type="component" value="Chromosome"/>
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    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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            <begin position="46"/>
            <end position="214"/>
        </location>
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    </evidence>
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    <name>I0A297_FERFK</name>
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                <person name="Bidzhieva S.Kh."/>
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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    <sequence length="408" mass="45353" checksum="5265B8925E591B1C" modified="2012-06-13" version="1">MISEKKLNSKQRKGEVKPLNSNEAVAEAVKDADVDVVAAYPITPQTIVVETLAELIGNGELNAEMIHVESEHSALSAVIGASAVGARVFTATASQGLALMHEVLHITSGLRLPVVMSVAMRALSAPISIFNDQSDIMNQRNTGWITIIASSAQEAYDSILQAYKIAENPKVLLPVMVSYDGYVLSHTIERVETVGKSVVEEYIPKKVTWNTLDVKDPITMGTITSPEYYYEFKYAQERALEESLSVIKSADEEFERLYGRSYGIIEGYKIEDAEVALLATSSYYTNLKVATDLARKEGLKVGTIKLRVFRPFPREELYSMIKDLQVLGVIDRAIAFGQKPSGPIANDIASALQYKKDKPIIQSIIAGIGQRRMLIEDFVKLYRMLVKNMNEKKFYEESIFYGVKGIEF</sequence>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Gumerov V.M."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
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        <property type="protein sequence ID" value="AFH43206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="EnsemblBacteria" id="AFH43206">
        <property type="protein sequence ID" value="AFH43206"/>
        <property type="gene ID" value="FFONT_1218"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020813">
        <property type="entry name" value="Fibrillarin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    <dbReference type="PROSITE" id="PS00566">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="109"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="134"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="4">
        <location>
            <begin position="154"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="235" mass="26606" checksum="E17AB9DF89E21C44" modified="2012-06-13" version="1">MSEPIKVKPLELNERIFEIEFDDGSKKLATINLVPGKKVYGERLYRIAGTEYREWIPYRSKLAGAIMKGIKAVPIKEGEKVLYLGAASGTTPSHISDIVGEKGIIYSVEFAPRVMREFLLVASDRKNLIPIMSDARKPQLYSHIVELVDIIYADVAQPEQASIVVENAKWFLKSRGKIFLAIKARSIDVTKEPTEVYKKEISILQENRFEIIDVVHLDPYDKDHAMVLASYEPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2P7</accession>
    <name>I0A2P7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Plant-type l-asparaginase (L-asparagine amidohydrolase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_1266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43254">
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        <property type="gene ID" value="FFONT_1266"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000007391">
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    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="185"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="207"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="3">
        <location>
            <begin position="156"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH43254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="291" mass="30855" checksum="601332ECC99466A2" modified="2012-06-13" version="1">MVHGGAGSWSKIPKETKISAQQALKDAVTFGMEILKREKSAVEAVAEAIRILEDSGSLNAGLGSVTNSEGYMELDAGIMDGKKMDAGAVAAIRGIRNPILVAMKVMRETPHVILVGEGAQKFALSKGFKIDERINVKKDVKDISINIEKRSNWIHDTVGAIAISSDCDTAAGASTGGIRGKMPGRIGDTPIPGAGYYANHFAAAAATGIGEVIILTGATRWIVERGTLAGNVLFVGKDLIEYVNRMYSTNTIGIIMADIRGNYGRIFNTEALPYGVFTEDMQSPEVGGIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2R5</accession>
    <name>I0A2R5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Component HyfI of membrane-bound [Ni,Fe]-hydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1284"/>
    <dbReference type="EnsemblBacteria" id="AFH43272">
        <property type="protein sequence ID" value="AFH43272"/>
        <property type="gene ID" value="FFONT_1284"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1284"/>
    <dbReference type="eggNOG" id="arCOG01553">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088839_0_0_2"/>
    <dbReference type="OMA" id="LRIYHAM"/>
    <dbReference type="Proteomes" id="UP000007391">
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    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="1">
        <location>
            <begin position="32"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="251" mass="28360" checksum="5A58BB33858A9461" modified="2012-06-13" version="1">MILEEEGKKLKKRAYDLLSRSVFVLRVDSGSCNGCDISVLASLTPLYDVERFGVKVVYSPRQADVILITGPITRQFYPAMKIIYESTPKPCVVVACGSCASSGGIWYNTYDTLGGADKVVPVDVYIPGCPPRPAAIIHGMLVALDVLEQKIKKLEYSEEKEWKTTESELKFGGLLKSYSVFRSLKLDCRRYLGYKLGNKFLMDYAEIMRNCNSLEELKKKTTGLLSRWNNDSRIKEIIELLNKRVEDYLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2S7</accession>
    <name>I0A2S7_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="47" mass="5444" checksum="F25C0A720BF62203" modified="2012-06-13" version="1">MLTKIAKSFLEIDITTESSTNYSKDRGLGIFRELLFYLSLVIIFAER</sequence>
</entry>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
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            <name>FAD</name>
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    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
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    </feature>
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        <location>
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        <location>
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    </evidence>
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    </evidence>
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            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AFH43309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="386" mass="43005" checksum="34BD5A3F272ABE29" modified="2012-06-13" version="1">MEVLALESSIYAEETYKNLIDSVKSKLSEFRRYSMEVDEKEDYNLVKRNLLKLGEDKLLGIFVPESYGGRGLDFRAFSFFTEELSRHCTSTAFSYIAHILSISSILFGGSEEQKRELLPVMSREKIGAFALAEPQAGSDVSSIRTNAVKKGGKYIINGEKRFITNAYISDYLILFAKTDPERGNKGLSAFIIDSKRQGVKISEPQPKMGMRGAPVSQISFKDVEASEEELIGKENEGFKIAMKSLDIGRIGASSISLGISKRALEVSLSFAKSRVQFNQPIADFEGIQFKLADMYAKMKAAEALTYHVSYMLDRGRAEPSDIATAKLFSSEAVNYIVSEALQIFGGFGYIRGAEVERLYRDARILSIGEGTSEIQKIIIARKLLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2V8</accession>
    <name>I0A2V8_FERFK</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    <dbReference type="EnsemblBacteria" id="AFH43315">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <location>
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    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="251" mass="27860" checksum="8C983EA3B22E4623" modified="2012-06-13" version="1">MVIEIEVKDVKVYYKSTKAIDGVSLHIKKGEVLCVIGPNGAGKSTLLRVINGILKPKIGTVYVDKRSIYEIPHKSAAKIFGYVPQKLHSFGMISVYDFVMTGRKPHIGLVPTKADDERVFKALKLVNMENFAERTLEELSGGELQRVLIARALAGEPEVLILDEPTNNLDLKHQTELLNLVKVLSNEGLIVIMSLHDLTQAYRISDKVLLMNKGKVVAFGEPSKVLRADILSRVYGVPIAILKEYKIVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Y6</accession>
    <name>I0A2Y6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
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    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1355</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Oxidored_q2"/>
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    </dbReference>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="98" mass="10741" checksum="A9EBE5DCD27FCE5A" modified="2012-06-13" version="1">MDVYKLVIAALLATGLTVILSSKSLVRMLIGAEVMFNGALLYLTYIASLVPVQGAVYSFFAIIIASSELLIAVSIVILYYRTHKTLEINVEQSEEEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Z0</accession>
    <name>I0A2Z0_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Replication factor C large subunit</fullName>
            <shortName evidence="4">RFC large subunit</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Clamp loader large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rfcL</name>
        <name evidence="7" type="ordered locus">FFONT_1359</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the activator 1 small subunits family. RfcL subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1359"/>
    <dbReference type="EnsemblBacteria" id="AFH43347">
        <property type="protein sequence ID" value="AFH43347"/>
        <property type="gene ID" value="FFONT_1359"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1359"/>
    <dbReference type="eggNOG" id="arCOG00470">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027255_1_1_2"/>
    <dbReference type="OMA" id="GGWTRYG"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01508">
        <property type="entry name" value="RfcL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023935">
        <property type="entry name" value="Rep_factor-C_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="44"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH43347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="458" mass="52156" checksum="9E7C914667F52192" modified="2012-06-13" version="1">MSAEKGLPWIIKYRPKSLKEYVNQETAVAIITSWIKDWEKRAPTKKAVLLYGPPGVGKTSLIEALANDYGYEIVETNASDYRRRDDIYRKVYNSAIQGTLTGRKKLILLDEVDGLSSTGDKGGIEAIVQLITQTKNPIILTANNAFHPDLKPIRDLAVMIELKNLNQKHVLTVLKIICEREGVECEDAGLKVIYEKNRGDLRACINDLQSIAEVYGKVNEELATELTYYRDRELNPFDTLRNIFTSKYVWQSRNAISHSEVDTDTLIEWLSENIPVQLTDPEDAYLAFQALSRADVYRGIIKKTGNYDFLAYITEMIGPAISFSRKKTKFKWLKYNYPSKLKMLSETKRSRELLNSSLQKLSKRLSQSTSKSKKDLLPYLRSIYRLSPPHFVQICRSYGITVEEAAVIVGDKQVEKAFAEMAAERQEKSAEKAEISRTQAKRAKGRTSKKRGGQTQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A305</accession>
    <name>I0A305_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Beta-lactamase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1374"/>
    <dbReference type="EnsemblBacteria" id="AFH43362">
        <property type="protein sequence ID" value="AFH43362"/>
        <property type="gene ID" value="FFONT_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1374"/>
    <dbReference type="eggNOG" id="arCOG00503">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036012_0_0_2"/>
    <dbReference type="OMA" id="CSGWRAK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="293" mass="32737" checksum="FA46B45BE77D26BE" modified="2012-06-13" version="1">MEHGFGKLDKLKVFVLAEDSVLYNTPYLAQHGVSFFVQTYSGSERANVLVDVGQNTYALMHNMELMNIDSSTIDAIVLTHCHYDHTRGIAEVLRKIGKRDLPVIAHPDIFRLNLSNDPVLRHVGMTLEDSREKIEESGGRLILARDPLMVFPGLITTGEVRRQTDFEGRGYRLFTVTDNGGVVEDRMMDDISVVGITNSGIVILTGCSHAGIVNIIKHSAELAKEDRVLAVIGGFHLIDASDERIEKTVRALSQMKIDRIYAGHCTGFKAQVELYREFGERFSPLHTGMSFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A307</accession>
    <name>I0A307_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1376"/>
    <dbReference type="EnsemblBacteria" id="AFH43364">
        <property type="protein sequence ID" value="AFH43364"/>
        <property type="gene ID" value="FFONT_1376"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1376"/>
    <dbReference type="eggNOG" id="arCOG02448">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2433718_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <sequence length="37" mass="4244" checksum="2B85F8AA2CC2A2B7" modified="2012-06-13" version="1">MRARSGKIVDKEETYVEPFLIFISSIRGASLFPEISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0046"/>
    <dbReference type="EnsemblBacteria" id="AFH42041">
        <property type="protein sequence ID" value="AFH42041"/>
        <property type="gene ID" value="FFONT_0046"/>
    </dbReference>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07282">
        <property type="entry name" value="OrfB_Zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="tspaseT_teng_C"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
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    <feature type="domain" description="OrfB_Zn_ribbon" evidence="4">
        <location>
            <begin position="42"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="169" mass="19092" checksum="773716FF6B96C808" modified="2012-06-13" version="1">MREASKRGYAIVMERLGRRPGEKMVSRIRDRQLRHRIFQAAFRGMQKAIEEKAREHGLPVVYVNPRNTSRLCPIHCSEIAYENGSRLGRCTKGGEAWHRDVVAVWNLLKIRLGDGSTAPSLGRSPLDGSLVPLGSTTTHEPTAIARDLWARWKSLDATKNLYKMIGMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZD1</accession>
    <name>H9ZZD1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FFONT_0095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0095"/>
    <dbReference type="EnsemblBacteria" id="AFH42088">
        <property type="protein sequence ID" value="AFH42088"/>
        <property type="gene ID" value="FFONT_0095"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0095"/>
    <dbReference type="eggNOG" id="arCOG04805">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138948_0_0_2"/>
    <dbReference type="OMA" id="VSHAIAP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="KdpC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="161" mass="17738" checksum="A20478897FA5D1FF" modified="2012-06-13" version="1">MEFGGGEKMTYFKRFLGAALLLLAMIAFLGLLYPALVWGISSLVSPWRAGGSLYTSCGKVISSDLISVYNESSPLFHPFPPNSTSSGVDPYIPLEEAMKQVERVSKETGIPREKLVDLLMSNAAYNDMIDLHVFSPGYSIVNVEEVNMQIMEMMNVTCGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZE4</accession>
    <name>H9ZZE4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP dependent helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0109"/>
    <dbReference type="EnsemblBacteria" id="AFH42101">
        <property type="protein sequence ID" value="AFH42101"/>
        <property type="gene ID" value="FFONT_0109"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0109"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002025_0_0_2"/>
    <dbReference type="OMA" id="VVDEWHE"/>
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        <property type="component" value="Chromosome"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DEAD/DEAH_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017170">
        <property type="entry name" value="Lhr-like_ATP-dep_RNA_helic_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045628">
        <property type="entry name" value="Lhr_WH_dom"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08494">
        <property type="entry name" value="DEAD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19306">
        <property type="entry name" value="Lhr_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037307">
        <property type="entry name" value="Lhr-like_helic_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="33"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="250"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="878" mass="100264" checksum="318E039AD85E6334" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZF5</accession>
    <name>H9ZZF5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0120"/>
    <dbReference type="EnsemblBacteria" id="AFH42112">
        <property type="protein sequence ID" value="AFH42112"/>
        <property type="gene ID" value="FFONT_0120"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0120"/>
    <dbReference type="eggNOG" id="arCOG04266">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162442_0_0_2"/>
    <dbReference type="OMA" id="CPYYDKR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="91" mass="10681" checksum="0C1ECDCCC057EEE9" modified="2012-06-13" version="1">MIDFSGSKDAQGLSEKDKWIQKMIKSAKKHHKLCPYFDKKTQKCFIRLGKTCDRDGKFDMCPTFMEFLSSKYDEYVSKNKPLPVDFMDIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZK0</accession>
    <name>H9ZZK0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0165"/>
    <dbReference type="EnsemblBacteria" id="AFH42157">
        <property type="protein sequence ID" value="AFH42157"/>
        <property type="gene ID" value="FFONT_0165"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0165"/>
    <dbReference type="HOGENOM" id="CLU_2366079_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="95" mass="10232" checksum="D5061BC22379F33D" modified="2012-06-13" version="1">MDEIAYLGILYFAIFIGFLAGIFGRKRFENGKGVKKAIGYGLEISVLVIIFSVGMEMGSSWETADVFLITISSIMGVLSGILGAFLAKIVMKGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZK2</accession>
    <name>H9ZZK2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoesterase, DHH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0167"/>
    <dbReference type="EnsemblBacteria" id="AFH42159">
        <property type="protein sequence ID" value="AFH42159"/>
        <property type="gene ID" value="FFONT_0167"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0167"/>
    <dbReference type="eggNOG" id="arCOG00425">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_786668_0_0_2"/>
    <dbReference type="OMA" id="FVEVVKY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="340" mass="39049" checksum="83D003A5F024B906" modified="2012-06-13" version="1">MTILLLTKEDALIIGDWDADGAVSAAILSYMQNSRAYPSNKKLVVYVRPSGPRELRKVMNDYSGCPEFIAFLDIPYIQENFGIFEDIKKSCPNTQVIYVDHHFSTIDNVEVLRKFIDKFRLGKDKPTSMHLLDIAHEIKLQLPQRLELFAKALWYIELGRKPSDEIKETVRVVATISRALKLNREEKFWEKMVRWLSNPLPIPLGKSDLEILNKVEEEIKKRDEELEKAVEDLAISARRVGCFRFVDARKKWKRRGVSSLATRLARKFKAPVALLAKVKDGEILVIRTKNATAKKIADELYAIGMAVNTGGHRNISIVRLKSGYDLKKIEDVLVKYCRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZL1</accession>
    <name>H9ZZL1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-aminobutyrate aminotransferase-related aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0177"/>
    <dbReference type="EnsemblBacteria" id="AFH42168">
        <property type="protein sequence ID" value="AFH42168"/>
        <property type="gene ID" value="FFONT_0177"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0177"/>
    <dbReference type="eggNOG" id="arCOG00915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_0_2"/>
    <dbReference type="OMA" id="GMTTQIY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="440" mass="49450" checksum="B164BC47DDEFABD3" modified="2012-06-13" version="1">MNYALTEKYLQERKDYVISAVSLYHPITVIRGENAFLFDTEGKKYIDFTSGIGVTSLGHANPELIDAAVEQLRKLWHISIMNLNYPSYVELAKKISEVSPGKEKKRVAFWNSGSEAIDNAIKVARQATGRHVIVAFENAFHGRGTYGPALAATGKYMPYKESMEPFSQGVELLPYPYCYRCPFRHEYPECGLACLDYMKKWFTHARYPPNRIAAFLMEMIQGEGGFVVPPKEYVKELKSFLESNGILLIDDEVQAGFARTGKMWAVEHFDVEPDIMAFAKAVANGLPLSGIAVRESIAEKVHLGSLGGTFGGNPVSCAVGLKVLEIMKRDNLPARAEMLGRIIRKRLEEMYEKYEIIGDVRGLGIMQAIEIVKDRKTKEPDEDITKKIINTARERGLLLLIAGLYSNVIRLHPPLTIEEDVLKRGLDILDESIKEALKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZL3</accession>
    <name>H9ZZL3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Natural resistance-associated macrophage protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0179"/>
    <dbReference type="EnsemblBacteria" id="AFH42170">
        <property type="protein sequence ID" value="AFH42170"/>
        <property type="gene ID" value="FFONT_0179"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0179"/>
    <dbReference type="eggNOG" id="arCOG04531">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020088_3_1_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="PTHR11706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="227" mass="24337" checksum="E7B9A1E046106B27" modified="2012-06-13" version="1">MTGKLENLKRILAIGPATLVSVAYIDPGNFGTNIEAGSKYGLTLLWVVWLSGAMAIMFQYISGKVGIVTEKGLLDVSMAKLRKNEKKLYFFGLFIAILATDMAEFVGMAVGFHLILGIPLSISAGLSVVDVLLLFLLTEDLGRMEIVIAGLVGIVGLSYLIELVIVHANPEEILMHSFIPYLSGSEMILTATSIIGATIMPHAIILHSYLSAEKSAGKGGIKQKRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZN9</accession>
    <name>H9ZZN9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0205"/>
    <dbReference type="EnsemblBacteria" id="AFH42196">
        <property type="protein sequence ID" value="AFH42196"/>
        <property type="gene ID" value="FFONT_0205"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0205"/>
    <dbReference type="eggNOG" id="arCOG00033">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022610_0_1_2"/>
    <dbReference type="OMA" id="ANDANPW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="Met_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_TRM5_TYW2" evidence="3">
        <location>
            <begin position="18"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="268" mass="30084" checksum="FA4D84D4FB7916D3" modified="2012-06-13" version="1">MSQNQLSNNKNLDSSSSFLVIGDIALVNLKNENEIDRGKELAEKILRVNKYIKSVYGKIGTEGEFRVPKIIHLLGEKKTETIAKEYGLLFYVDISKVYYNPRLAEEHHYISQISEDGEVVLDLFSGIGGFSIHLAAAKRAIVFANDINPYAIKFLNASVLLNKKKIIGEVIASNLEANKLLLMMSKKAKFDRIIMNNPTMIEGFLQNVNAVVKTGTTLHIYALIVKDKLEEKVKGIASLIKSSRIDYIKEAIEYSPSKSIYRIDISVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZQ5</accession>
    <name>H9ZZQ5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0221</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0221"/>
    <dbReference type="EnsemblBacteria" id="AFH42212">
        <property type="protein sequence ID" value="AFH42212"/>
        <property type="gene ID" value="FFONT_0221"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0221"/>
    <dbReference type="eggNOG" id="arCOG00194">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_2"/>
    <dbReference type="OMA" id="RWFGNVV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="301" mass="33438" checksum="D61C6FAA3B512326" modified="2012-06-13" version="1">MIEINNISKYFGNVKAIENVSFNVSNGEIVGYVGLNGAGKTTTIRVAVGVLPPDSGDVSIDGFSITRDKRKASEKIGWVPELPIFETDFKALDYFVYLAGYYGLSSSEAKKMGKEMLERFGLENALNMKLSAFSQGMKKRFALAVSMINDPPNFIFDEVLNGLDPQGIAFFRDMAVDFKKRKKAILFSSHILGEVQNIADRVVFIHKGKVIGSYKVDEIINTVKPSIVIKLDKIDDNTVNLLEKYGKVSKQGEYVVISSPSVSSGEVVKVLVEKGLNVLEIKYEERSLEDFFFSLLKSRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZT3</accession>
    <name>H9ZZT3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0249"/>
    <dbReference type="EnsemblBacteria" id="AFH42240">
        <property type="protein sequence ID" value="AFH42240"/>
        <property type="gene ID" value="FFONT_0249"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0249"/>
    <dbReference type="eggNOG" id="arCOG00946">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_2"/>
    <dbReference type="OMA" id="YHFYPGS"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldolase_TIM"/>
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        <property type="entry name" value="AmmeMemoSam_rS"/>
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    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="83"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="354" mass="40627" checksum="35E344DF05CEA969" modified="2012-06-13" version="1">MVDEYRTPLNNSQNLRVAKFWDQVEGKEKTVKCKLCKRYCEISNNSYGACGVRKNIDGKLYTLVYGLLTAVAIDPIEKKPLFHFKPGSSVLSISTVGCNFFCQFCQNWEISQSRLEEGLYGNYYEPEEIVNIALSNRADGISYTYNEPTVFYEYMYDVAKIAKQKALFNTMVTNGYISEYALEEISSYMDAATVDFKGSGNKEFYQKYMGVPDPSPIFDTLTLMKEKKIHIEITDLVVPKIGDREEDIDKLTKWIVENLGDETPFHILRFYPQYKLNYLPITPVKTLEKFAEIAKNNGLKYVYIGNVPGHGLENTYCPSCGKVLIEREGFYIEKINLTEDGRCKYCGYKTNIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>H9ZZW7</accession>
    <name>H9ZZW7_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="5">OPRT</shortName>
            <shortName evidence="5">OPRTase</shortName>
            <ecNumber evidence="2 5">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pyrE</name>
        <name evidence="7" type="ordered locus">FFONT_0284</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0284"/>
    <dbReference type="EnsemblBacteria" id="AFH42274">
        <property type="protein sequence ID" value="AFH42274"/>
        <property type="gene ID" value="FFONT_0284"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0284"/>
    <dbReference type="eggNOG" id="arCOG00029">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_2_0_2"/>
    <dbReference type="OMA" id="MKAYQRQ"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="6">
        <location>
            <begin position="57"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="5">
        <location>
            <begin position="113"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="194" mass="21563" checksum="274E0BF94BF236C6" modified="2012-06-13" version="1">MSGIAVEFLKNGIIKIGKFKLTSGIESPFYIDLRRLYSFPSLREKVVEEIVKRFPTDQADVIVGIATSGIALASFIGCKTGKPIAYVRLDRKEHGTQALLEGEVRNKKAVVVDDVATTGGSLEHAISAVKEMGGNVMFSVVVVDREQGAREKLKSIGVELYSLFTAKELFKELYESNTIDEKTYKEIQEYLSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A006</accession>
    <name>I0A006_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">AIR synthase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0323"/>
    <dbReference type="EnsemblBacteria" id="AFH42313">
        <property type="protein sequence ID" value="AFH42313"/>
        <property type="gene ID" value="FFONT_0323"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0323"/>
    <dbReference type="eggNOG" id="arCOG00636">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041631_0_0_2"/>
    <dbReference type="OMA" id="PRVVMGH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="52"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="162"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="357" mass="39626" checksum="B7F54A9DB569FCF8" modified="2012-06-13" version="1">MNGLSLFKLGKLPNDIFDRIIYPNIGLLRDNVMVRPKHGVDVGVFDIGEYSIIVKTDPVFVVPEYGWEKSAWFAVHILASDVSTSGNPAQYMAIDLNLPKKITKEQFSVLWSKISDECKKLGISIVAGHTGIYDGTDYPMIGGATVLSVAKKGNYVTTEMAEEGDLILMTKGPAIEAVGILSTMYPEIVEKEGGNELRRKGESFFYKMSVVEDALSLSSLGLRTAITSMHDATEYGVWGALHDISRASNSLVEIQEESLFIDDDVEKILRIFEEKTKIPIDPYASISEGTLIATVKKEYADQAIDVLSRKGIKAGIIGRIREKGKRGVYIKGKNTIKELKFPEEDPFWKVFFALNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A049</accession>
    <name>I0A049_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_0366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0366"/>
    <dbReference type="EnsemblBacteria" id="AFH42356">
        <property type="protein sequence ID" value="AFH42356"/>
        <property type="gene ID" value="FFONT_0366"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0366"/>
    <dbReference type="eggNOG" id="arCOG05120">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1080107_0_0_2"/>
    <dbReference type="OMA" id="NERCWAN"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="5">
        <location>
            <begin position="40"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH42356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="263" mass="30864" checksum="AA02E628938187A2" modified="2012-06-13" version="1">MINSFIDNTGYNPIELGKTIEKIILKEDHGIWLRKYYRFRGGKWYGGIATADCIGCNLRCKFCWAWRQRDYPERFGNFYSPEQVASKLIRIANEKSYKNIRISGGEPTLGFEHLIQVLENLKNYDMTFILETNGIYFGYYNELSPELSNFENVHVRVSIKGCTPEDFHSITGAKKEFFQVQINALKNLIDSNVRAHPAVMESFSEEESCKDLREKLGDIDSSLYENYEEEFVFLYPHVVEILRKNKIWPRKAFYPNNIPEKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>I0A051</accession>
    <name>I0A051_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Peptidase, family S26B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">FFONT_0368</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0368"/>
    <dbReference type="EnsemblBacteria" id="AFH42358">
        <property type="protein sequence ID" value="AFH42358"/>
        <property type="gene ID" value="FFONT_0368"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0368"/>
    <dbReference type="eggNOG" id="arCOG01739">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_745187_0_0_2"/>
    <dbReference type="OMA" id="THRRYAL"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S24" evidence="10">
        <location>
            <begin position="29"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH42358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="354" mass="40198" checksum="C293BCF472C368BC" modified="2012-06-13" version="1">MKHLKKVIIGSISLILVLLLMGKIIGLPVALFVVSGNSMYPTLKTGDIVVGITDKNYKNGEVVVWCVSKTQCVIHRIVGTYNEYVITKGDNNPYIDPPILYSNVKYKELFVIPNYIWILIFLLVALYIFFNRKSFLPSGFSISVLVFGIYVLISVILLITMPVEIETSSILPYQPGVNLTGYNFNSDGSVSLNYSAENISFQNIKSCYILSPVSENLTQCFINNQTIVIEVPYVIYQRAYYNGSNILEVGISAELDKGNLSGIYYLNVPFQKLEFSIDNFTLFIRNGNFFPVDVNITLDYADFPGRQFDSKSFELRVPQNSELAYPFEKHAYEYVDVQYIYDGNQIFLKYYVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A087</accession>
    <name>I0A087_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_0404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="2"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1163730.FFONT_0404"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="entry name" value="AAA+_ATPase"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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    </dbReference>
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    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="63"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="453" mass="51288" checksum="CCCCA7386BF35E8E" modified="2012-06-13" version="1">MSIIEELPKVKEFKRIGFHSHIKGLGLDENGKAKQIADGLVGQIEAREAAGIVVQMIKEGKMAGRGILFVGPTGTGKTALAVAIARELGEDTPFVEFTGSEIYSTEMKKTEMLMQTLRKSIGVRIKEKRTVYEGAVKELKIRRLRNPYNPYMMIPREAKITLETKDENITLTVSEEITQQLLELGIKKGDVIWIDSQTGRIFKEGRLKEEAEEKSPYISSERIMEMPQGPIKKDKEIVHTITLHDLDIYFATRKAGLEILFGFSPLKEIGQDVRKEVDEQVKKWINDGMGEIIPGVLFIDDAHMLDLEAFSFLTRAMESELAPIIILATNRGITKIRGTDIESPHGMPLDLLDRLLIITTRPYNRDEIKQIILIRSEEEDIPLSDDAIEELTNIGVNRSLRYAIQLMVPAKVLAIRKNKQKVTKEEVIEASAKFIDLKSSIDYITKYEQLMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A090</accession>
    <name>I0A090_FERFK</name>
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        <submittedName>
            <fullName evidence="2">Putative stress protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0407</name>
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    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
            <taxon>Archaea</taxon>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0407"/>
    <dbReference type="EnsemblBacteria" id="AFH42397">
        <property type="protein sequence ID" value="AFH42397"/>
        <property type="gene ID" value="FFONT_0407"/>
    </dbReference>
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    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
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    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="16"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="140" mass="15349" checksum="3D7F32735199BBB8" modified="2012-06-13" version="1">MSSYVDRAFSLSYALRRILVAFDGSASSERGLKIALELSRMLGSEVHVIYACSNNSCNENIIKKAEILAKERGVEIISKVTKFNPEESSVSNELIKEINSKNYDLVIMGTRGKTISAEISKGSTAAGVFVNTDVSYLFIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0B4</accession>
    <name>I0A0B4_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ordered locus">FFONT_0431</name>
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    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0431"/>
    <dbReference type="EnsemblBacteria" id="AFH42421">
        <property type="protein sequence ID" value="AFH42421"/>
        <property type="gene ID" value="FFONT_0431"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0431"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2565560_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="81" mass="9707" checksum="DDFE05E3375935D5" modified="2012-06-13" version="1">MITLSIYWYRCDLCGKNSPTANCTIKNRKLNVCYRCFITFKLWNKCSDYGWKIEVKRLSNANTEEKLEKLEFILEEISKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0D2</accession>
    <name>I0A0D2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">50S ribosomal protein L24e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpl24e</name>
        <name evidence="11" type="ordered locus">FFONT_0449</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
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            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0449"/>
    <dbReference type="EnsemblBacteria" id="AFH42439">
        <property type="protein sequence ID" value="AFH42439"/>
        <property type="gene ID" value="FFONT_0449"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0449"/>
    <dbReference type="eggNOG" id="arCOG01950">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190191_0_0_2"/>
    <dbReference type="OMA" id="GTGKMYV"/>
    <dbReference type="Proteomes" id="UP000007391">
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</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
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                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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    <sequence length="105" mass="10947" checksum="F5E3FC3E60B90931" modified="2012-06-13" version="1">MSGAETASRVSGGMVVKADREKPSPYAAMISAARAAQQAMERGITAIHIKVRAPGGHGPKTPGPGAQAAIRALARSGFIIGRIEDVTPIPHDTTRRPGGRRGRRV</sequence>
</entry>
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    <accession>I0A0G4</accession>
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    <protein>
        <submittedName>
            <fullName evidence="2">Dolichol kinase</fullName>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
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                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="AFH42471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42471">
        <property type="protein sequence ID" value="AFH42471"/>
        <property type="gene ID" value="FFONT_0481"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
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            <end position="30"/>
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        <location>
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            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="227" mass="26105" checksum="9BFDC4ABFED19CE7" modified="2012-06-13" version="1">METYSIDVFIRDLAVAIPLAIYVFLLICYVTRKTYDAMIKRGVKERKAVYYNRKIIHIFVGGVVSAFIPFIFKEPFTPFLFAVLLGSFLLYKHKSRKKYYWFQVDENKYEVNFAFAWGFSILILWLYLGNPFVAMLPPMLISFGDGITGIVRNLLFGKRTKHWAGNLAMAALMIPIGYIYAGYWGVIASVVASFVERYEYNPLDDNILIVLSSSIILIIAKFFSFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0J2</accession>
    <name>I0A0J2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="primary">rpl24</name>
        <name evidence="5" type="ordered locus">FFONT_0509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <text evidence="2">Located at the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="2">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 50S ribosomal subunit.</text>
    </comment>
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        <text evidence="1 2">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
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        <property type="match status" value="1"/>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
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    </evidence>
    <sequence length="158" mass="18109" checksum="270E61B057ED8B4E" modified="2012-06-13" version="1">MSLTKSIKPKKQRKILFNAPLHIREKLVTSPLSKELRNKYGIKRLPVRSGDTVKIMRGNNAGLEGKVVKVNRKTGRVHIEKVTRDRADGTPVFIPIHASKVMITKLDLSDKERKQIIERKTGRKVIEEKEEEKKETETAEAKEEKEESKVEKSEEVGK</sequence>
</entry>
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    <accession>I0A0K0</accession>
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            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
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            <dbReference type="EMBL" id="AFH42507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="435" mass="50330" checksum="6BA58E93D0D88181" modified="2012-06-13" version="1">MLSDEINLDEVISIVQGIAGRLRERNVLVSTSEIENAVKLYITATQLSPYGYFPLKPVIESVFVKRKYDEEIFNDAWRDISKVSYGEKIRASEKPKEKLLKGKRIEEKEEHESLDIARMQKLSVGKLRKMGKFNEENKRKLEIARKINTLQKYYETGNRGYIDLLESELKASQKKKGSYESKDSYSASSRYEAIEKLLFRIVENPDNANALLALSKITGSDLPIEAIKYFVKKRKTFLVEKIAASIFKRSGGLLKGKKYEKGYIYGRVDIRKTLFELSRNHPEELVFKQKKRENGAILVIDKSDSMRKRSTSVIKIASQYYPFLKSLILFDTEVKVKKISRSSSRWNIVKDLLSMNFSGYTNISKALRQVIEISKPKDTVIIISDMEQTVEDEFYISLIDKLIRKKVRLIIFTSEEYAKIFKQIFPSSVNVKLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0L4</accession>
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        <recommendedName>
            <fullName evidence="2">DUF1616 domain-containing protein</fullName>
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    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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            <begin position="70"/>
            <end position="175"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42521.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="185" mass="21099" checksum="B7C50039DA2FFF7D" modified="2012-06-13" version="1">MGSLEETLEDYIARKKKNKKTEFELKKEVFNEFSSRNIYLVDPNPPLKFSNYITRMEYSLWFWTVLSFTLVSLTLIYVTNFLSILMPLRYIFGSIFVLFLPGYSLVEALYPGEGDLSPLERLALSIGLSLAVVPLIGLLLNYTPFGIRLLPIAASLSMFIIILSVYALYRKFSINSLLVASQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0L8</accession>
    <name>I0A0L8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methanol dehydrogenase regulatory-like protein</fullName>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0535"/>
    <dbReference type="EnsemblBacteria" id="AFH42525">
        <property type="protein sequence ID" value="AFH42525"/>
        <property type="gene ID" value="FFONT_0535"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0535"/>
    <dbReference type="eggNOG" id="arCOG00434">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_2"/>
    <dbReference type="OMA" id="GHPDILP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="36"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="317" mass="35712" checksum="826461377CB6BDEE" modified="2012-06-13" version="1">MSKKIDEKLRNVIEFLKSYIIGYEELFELLSISLLSGGHVLIEGPPGSGKTLTARLLALSIGGTFKRIQMTPDMLPSDILGGFFYDIGKGEWIFREGPIFANVIFIDELNRASPRTQSALLEAMQEGRASIEGVTKELPRPNLFIATQMTKSEVGIYPLTPTLLDRFAFSYITNYLETDKEKEVLDKVDAIDEVIKSTSVSPILSIKDILMLQEEIKKVYVDDKIKLYIASIVGELRKKEDMFVIAPSTRASVWLFKGSRALAFLEGNDYVSPDHVKKIARYVLRHRLFFNPEAELKNVTSENIISSVLEKVEVPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0L9</accession>
    <name>I0A0L9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0536"/>
    <dbReference type="EnsemblBacteria" id="AFH42526">
        <property type="protein sequence ID" value="AFH42526"/>
        <property type="gene ID" value="FFONT_0536"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0536"/>
    <dbReference type="eggNOG" id="arCOG01314">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_859483_0_0_2"/>
    <dbReference type="OMA" id="YIDEAHH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="324" mass="36578" checksum="0B1848DFDE214366" modified="2012-06-13" version="1">MKNYIILGTVLFLIIALFSIYIIPSTSDFSPYNPLYNGLADFVHEFNVTLIPINSLNNLKQGTVVFLIGPSKNFTEQEGMEILSYVENGGELVIMDDFGTSNELIKIMNLNGILNGSLLGDPLFMYKSFQLPIVKVNVNGTTLNVYYNYATVITSQNSNLNCIGESSYFSYLDLNLTGKYLNGYPKGPFCIAYMQNIGKGVVYVFSDSSPFINSMLNLGDNHKLATILISGKIPYLIDDKWYVNNYDVLRTNTFNFFSQILPSIVYPLALISVLASYIVGNYIYINLVKKRTKKKSNLEKILKVHPEWNKDVLIKLMKEADKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0N3</accession>
    <name>I0A0N3_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Threonyl/alanyl tRNA synthetase, SAD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">FFONT_0550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0550"/>
    <dbReference type="EnsemblBacteria" id="AFH42540">
        <property type="protein sequence ID" value="AFH42540"/>
        <property type="gene ID" value="FFONT_0550"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0550"/>
    <dbReference type="eggNOG" id="arCOG01254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_3_2_2"/>
    <dbReference type="OMA" id="LMRLHTA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II_ALA" evidence="3">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFH42540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="248" mass="28573" checksum="08DA6B737DFE11C8" modified="2012-06-13" version="1">MHYYYNKKVVNMTEHIYQLDSYLKEYDSIIVSIKDNSIILDKTIFHPRAGGLESDTGFLEVNGRRYKVLNVLQEKDSEDVLHQLDTVDGLNPGDRVHLALDWERRYKMMKLHTASHIIAAIIYNDYNALITGGNITPEYAYDDYSLESSDRSIFDKVVQKANEVVKKNIELKIYWLDREEAMKIPGIVKLAARMPPNVKKLRIVEIPGVDIQADGGPHVKNTGEIGEIVITKIENKGKNRKRMYYTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0P6</accession>
    <name>I0A0P6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="5">FGAM synthase</shortName>
            <ecNumber evidence="5">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="5">FGAR amidotransferase II</shortName>
            <shortName evidence="5">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">purL</name>
        <name evidence="9" type="ordered locus">FFONT_0563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_0583"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0583"/>
    <dbReference type="eggNOG" id="arCOG01158">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="216" mass="24483" checksum="D11538E4973661D6" modified="2012-06-13" version="1">MKAFIDLDLTITSERTAFVISRSFGLEEKTRQILLSREDEYIKSIKISNLLSGIDLRGINKAVLNTKIFDCTEKLLNLLKEKGFEINIVSLAYKQPIQALFKYKLNISNVNIFAPELVVERENSKVIGVKISIGKIETPWCLNCPVCKRYIVRRNKDEFTLAIGDSIVDLCMFLEADKSILIDNGNVPCFLKNKATYAVKDLCSAIRIIENLGDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>I0A0T0</accession>
    <name>I0A0T0_FERFK</name>
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        <recommendedName>
            <fullName evidence="2 4">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rps12</name>
        <name evidence="5" type="ordered locus">FFONT_0597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
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            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 4">With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_0597"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0597"/>
    <dbReference type="eggNOG" id="arCOG04255">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
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    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="term" value="F:structural constituent of ribosome"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_A">
        <property type="entry name" value="Ribosomal_S12_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_S12/S23"/>
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        <property type="entry name" value="Ribosomal_S12_arc"/>
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        <property type="entry name" value="Ribosomal_S23_euk/arc"/>
    </dbReference>
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        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="147" mass="16243" checksum="6EE82EC75DB41375" modified="2012-06-13" version="1">MPGKKSPLGLFAARTLRRKKLKFRWSQREFKRRMLNLKKKADPLEGAPRASGIVLEKVGVESRQPNSAVRKCVRVQLVKNGKVVTAFVPSDGGLNFIDEHDEVVIEGIGGPKGRSMGDIPGVRYKVVMVNGVSLDALLKGKKQKPVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A123</accession>
    <name>I0A123_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0692"/>
    <dbReference type="EnsemblBacteria" id="AFH42680">
        <property type="protein sequence ID" value="AFH42680"/>
        <property type="gene ID" value="FFONT_0692"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0692"/>
    <dbReference type="HOGENOM" id="CLU_2127731_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="113" mass="13067" checksum="EFF6AE3F644C7B8E" modified="2012-06-13" version="1">MDSLSVFFSGWKKVSVRKEEAEFSYFYTVSDVETWKALNEIEKGGIIEEILSVKDKCDLNDREKTYELNRLGWWVDVGIEGFSKEFELKEGNLRAVIGVSCMDGKVRIVIYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A156</accession>
    <name>I0A156_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA/RNA-binding protein Alba</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">albA</name>
        <name evidence="9" type="ordered locus">FFONT_0725</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
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            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="7">Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the histone-like Alba family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0725"/>
    <dbReference type="EnsemblBacteria" id="AFH42713">
        <property type="protein sequence ID" value="AFH42713"/>
        <property type="gene ID" value="FFONT_0725"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0725"/>
    <dbReference type="eggNOG" id="arCOG01753">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110989_1_0_2"/>
    <dbReference type="OMA" id="QFNEGAK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01122">
        <property type="entry name" value="AlbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013795">
        <property type="entry name" value="DNA/RNA-bd_Alba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028732">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="SSF82704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Alba" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="79" mass="8688" checksum="CE7ABA80913BBEF5" modified="2012-06-13" version="1">MNYVMAVLALLNQGVDEVIVKARGRAISKAVDAVEIIRNKLLAEKVEVKDIKIGSQVVQGQDRTSRVSTIEITLKLGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A158</accession>
    <name>I0A158_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FFONT_0727</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0727"/>
    <dbReference type="EnsemblBacteria" id="AFH42715">
        <property type="protein sequence ID" value="AFH42715"/>
        <property type="gene ID" value="FFONT_0727"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0727"/>
    <dbReference type="eggNOG" id="arCOG01352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_1_2_2"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016639">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01076">
        <property type="entry name" value="NAD_bind_1_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="183"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="71"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
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        <location>
            <position position="95"/>
        </location>
        <ligand>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="191"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="426" mass="47622" checksum="F276C9F8B693140C" modified="2012-06-13" version="1">MVMNLSKYFEWELGVLKEAVNLAGLPSEVFDYLSKPDRIIQVKIPLRLDNGKLVVFEGYRVQHNNALGPYKGGIRYHPEVTLETDMALALGMTLKNSLAGIPYGGGKGAVKVDPSKLSMRELEALSRTYVRGIYKLIGPEEDIPAPDVNTNPQIMAWMVDEYSKLTGKNVPAVFTAKPPELWGNPVRIYSTGYGVAVMAKEAADLWMGGLKDKKVAVHGFGNVGSYAAYWISKFGAKVIAISNAYGSVYDPEGIDVELALKSPEILKDVRNYPRGQKSNDPDTILYTDVDILLPCSLENVITAEKAKNIKAKLIVEGANGPTTPDAEKILYSRKDFVAVIPDILANAGGVIMSYLEWVENLQWYFWDEEETRQKLSSIMSNNFNRTNIYWNKLRERHPERLVTMRDAAFALAVERVYTAMKLRGWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A179</accession>
    <name>I0A179_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0748"/>
    <dbReference type="EnsemblBacteria" id="AFH42736">
        <property type="protein sequence ID" value="AFH42736"/>
        <property type="gene ID" value="FFONT_0748"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0748"/>
    <dbReference type="HOGENOM" id="CLU_1830515_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="140" mass="16208" checksum="E15C0A4288208DD5" modified="2012-06-13" version="1">MKTNPRNEELYRLIRKKLEGSPWLDDLLAQLTDCEGSAFDSIIIYDSSGKLHKGVKMRVKPVLESDGYSVDYAENITLLESESDWEELPKSTENCIDTRILKQGELVVIECIEPKLSLEEVFRIIKEMESPSVLCYYEWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A191</accession>
    <name>I0A191_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAM hydrolase / SAM-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0760"/>
    <dbReference type="EnsemblBacteria" id="AFH42748">
        <property type="protein sequence ID" value="AFH42748"/>
        <property type="gene ID" value="FFONT_0760"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0760"/>
    <dbReference type="eggNOG" id="arCOG04309">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059734_1_1_2"/>
    <dbReference type="OMA" id="EGYVGAM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002747">
        <property type="entry name" value="SAM_Chlor/Fluor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023227">
        <property type="entry name" value="SAM_OH_AdoTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023228">
        <property type="entry name" value="SAM_OH_AdoTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35092">
        <property type="entry name" value="PTHR35092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01887">
        <property type="entry name" value="SAM_adeno_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006779">
        <property type="entry name" value="UCP006779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101852">
        <property type="entry name" value="SSF101852"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102522">
        <property type="entry name" value="SSF102522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="270" mass="30186" checksum="FB15D306102AEDE9" modified="2012-06-13" version="1">MERSYEEGLIAILTDFGDIDNYVAVMKAVIMKENRRVKTLDISNNVLPFSIISGSYLLYTSYKYFPSGTVFLAVIDPGVGSDRKALIVKAGDWFFVGPDNGIFWPIIEENFSQAEAYSISIEKSDLRNISSTFHGRDVFAPIAARLAKNGDPGFFGDPLNLESLSKLSLIKMQKDGAYICFEIIHKDVFGNVVLSSKGKILSIMGKDVEVLKKSDNKKYIFKNVPTFSLLEENELAIYENSFGFLELAKNKGNLFADYGFKIGEKVCLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1B4</accession>
    <name>I0A1B4_FERFK</name>
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        <submittedName>
            <fullName evidence="1">Ornithine cyclodeaminase/mu-crystallin</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ordered locus">FFONT_0783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0783"/>
    <dbReference type="EnsemblBacteria" id="AFH42771">
        <property type="protein sequence ID" value="AFH42771"/>
        <property type="gene ID" value="FFONT_0783"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0783"/>
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        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042088_1_0_2"/>
    <dbReference type="OMA" id="AVKAFTY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023401">
        <property type="entry name" value="ODC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="PTHR13812"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001439">
        <property type="entry name" value="CryM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="324" mass="35407" checksum="6E6E83B5A74C3D24" modified="2012-06-13" version="1">MSPSVLLVSGNEIENLMDLNLVSKAIEDALIKFSKRETLTPERTVMRIKGNWWAVMQSYIPSEGIGVKVVSQIPENFSRGLPTIQAVTLLFNESNGELIGIFDGNILTALRTGAASAISIKYLAPKNTGPIGIIGTGYQAKYQLKFSSLFYKTRELMIFDINKNRENEFKTWAESLGYVVSSANSIEELVKSSKVVIEATTTKTPIILGEWLDDDKHIISIGAHSLEERALDDEAIKKIGKIVVDSRNATLNEAGDIAEPVKKGILDFEDITEIGEIAAGKKKGREGNEITLFKSVGLAVEDVAVALLAYNIAKSKGLGKEIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2020-08-12" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1C4</accession>
    <name>I0A1C4_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromatin protein Cren7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">creN7</name>
        <name evidence="3" type="ordered locus">FFONT_0793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="2">Methylated at multiple sites, to varying extents.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Cren7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0793"/>
    <dbReference type="EnsemblBacteria" id="AFH42781">
        <property type="protein sequence ID" value="AFH42781"/>
        <property type="gene ID" value="FFONT_0793"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0793"/>
    <dbReference type="eggNOG" id="arCOG04114">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2911298_0_0_2"/>
    <dbReference type="OMA" id="LAPEKAW"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01387">
        <property type="entry name" value="Chromatin_Cren7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038647">
        <property type="entry name" value="Cren7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020906">
        <property type="entry name" value="dsDNA-bd_Cren7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11520">
        <property type="entry name" value="Cren7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="60" mass="7226" checksum="46CD2CE56588672C" modified="2012-06-13" version="1">MEKRPVKVKDRITGKEYELVPIKVWKLSPNKKRGIKMGLFQNPETKIYFRARVPDDYPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1E1</accession>
    <name>I0A1E1_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">16S rRNA aminocarboxypropyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0810"/>
    <dbReference type="EnsemblBacteria" id="AFH42798">
        <property type="protein sequence ID" value="AFH42798"/>
        <property type="gene ID" value="FFONT_0810"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0810"/>
    <dbReference type="eggNOG" id="arCOG04733">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035060_4_1_2"/>
    <dbReference type="OMA" id="LGLFKWM"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:18S rRNA aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="PTHR20426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribo_biogen_C" evidence="7">
        <location>
            <begin position="50"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AFH42798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="183" mass="21036" checksum="57292D7C986E8D79" modified="2012-06-13" version="1">MLLQNYCSNLKIYVYRISEDYYKASTAVKLYKLKVATRVGDPRKLRGKFIVLDPFSQKVISKDDISYNLNGILVVDRSWNKILEKGGEVFPFKFGVRRRLPIFIASNPINYGIAYKLSSAEALAAALIILGCIERAKEILSYFKWGENFFSLNSKLIIDYVKASNEKDVLEIEEEFIKDIQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1F5</accession>
    <name>I0A1F5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0824"/>
    <dbReference type="EnsemblBacteria" id="AFH42812">
        <property type="protein sequence ID" value="AFH42812"/>
        <property type="gene ID" value="FFONT_0824"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0824"/>
    <dbReference type="eggNOG" id="arCOG00352">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011784_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G" evidence="1">
        <location>
            <begin position="171"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="339" mass="38851" checksum="FEA566F6469AE2ED" modified="2012-06-13" version="1">MPGDKNEDSISEIKHIHLPEYEEIYNKVYRRVGKIIAKQKTLKTSYGRENAIELLNTAYNIIKDKIEEYDKLYKLISKNEKVKGYLLIVLGEDAINKLKKASYLKYKLSQVYSLAKIEMLSSDDRDLRKKGIRAASRLISLVKRNKKLLEDIINIKKELQLIADTGEFPPIVIVGPPNSGKSTLVQKIAESRTIVASYPFTTKEVVPGRLKASQLINLTVLDTPGILRKNFSEMNIIERRAFATLKIFNGVIVFVMDPSKESTMNLKEQLELIKMFRVEVLNVIVAVNKVDLIENFEKDVIRSELEKIGVYDIFFISALNNINIGELVEYLKEKVLQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1G2</accession>
    <name>I0A1G2_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycerol-1-phosphate dehydrogenase [NAD(P)+]</fullName>
            <shortName evidence="11">G1P dehydrogenase</shortName>
            <shortName evidence="11">G1PDH</shortName>
            <ecNumber evidence="11">1.1.1.261</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Enantiomeric glycerophosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">sn-glycerol-1-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">egsA</name>
        <name evidence="15" type="ordered locus">FFONT_0831</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="16" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NAD(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:21412"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>NADP(+) + sn-glycerol 1-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.261"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the glycerol-1-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.261" evidence="11"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0831"/>
    <dbReference type="EnsemblBacteria" id="AFH42819">
        <property type="protein sequence ID" value="AFH42819"/>
        <property type="gene ID" value="FFONT_0831"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0831"/>
    <dbReference type="eggNOG" id="arCOG00982">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038362_0_0_2"/>
    <dbReference type="OMA" id="ALHGEQC"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106357">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106358">
        <property type="term" value="F:glycerol-1-phosphate dehydrogenase [NADP+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00497_A">
        <property type="entry name" value="G1P_dehydrogenase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023002">
        <property type="entry name" value="G1P_dehydrogenase_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032837">
        <property type="entry name" value="G1PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016205">
        <property type="entry name" value="Glycerol_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43616">
        <property type="entry name" value="PTHR43616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13685">
        <property type="entry name" value="Fe-ADH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000112">
        <property type="entry name" value="Glycerol_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 11" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0521">NADP</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="100"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 13">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000112-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="AFH42819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="354" mass="38331" checksum="99B671DAD5ECB6E4" modified="2012-06-13" version="1">MEKDVHIIDLMKRVVIGKDLLKDIIQYLPLNLSKNIKKVYVVTGPHVWDTYGKKLEEGLKSKELELYIKKSESPTIEEAKQIISDAKGKSIDLIIGFGGGKSIDLAKYAASQISIPFISIPTSASHDGIASPFASLKGGGWSTSVKAVEPICVIADLEIISSSPRKLLIAGAGDAIAKLTAVSDWRLAHLLRNEYYGSYAAGLSLLSAKHIIKYSDIISKTDVEATRIVLEALISSSVAIGIAGSTRPASGSEHLFSHALDKIAPKPALHGEQTGVGTIMMSKLHRMNWKKVRRVLKKVGAPTTAKELGIPENIIIEALTIAHKIRPERYTILGDRGLTWEAAEKLARDTGVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1I2</accession>
    <name>I0A1I2_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0851"/>
    <dbReference type="EnsemblBacteria" id="AFH42839">
        <property type="protein sequence ID" value="AFH42839"/>
        <property type="gene ID" value="FFONT_0851"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0851"/>
    <dbReference type="HOGENOM" id="CLU_2270934_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="102" mass="11812" checksum="86564085A604CA8D" modified="2012-06-13" version="1">MPGEVLVKFKDMLYKEAEETKKQALSTIKLSIEVYKDGEKELALVVLKESMRIAKSYLELMDKLDADKDTAISIITAIEEIEELMNQNEKVSYIYDIYNELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1I8</accession>
    <name>I0A1I8_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2, 5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 1-reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_0857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0857"/>
    <dbReference type="EnsemblBacteria" id="AFH42845">
        <property type="protein sequence ID" value="AFH42845"/>
        <property type="gene ID" value="FFONT_0857"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0857"/>
    <dbReference type="eggNOG" id="arCOG01484">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_4_1_2"/>
    <dbReference type="OMA" id="CECGQEV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RibD_C" evidence="1">
        <location>
            <begin position="3"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH42845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="228" mass="25874" checksum="152A3326223C5C73" modified="2012-06-13" version="1">MIHVRISMAMTADGKTADEEGEWYPLCQYERERFYRNIEWSDAVVVGADTVLTTNISFLSPSSLKNPLRAVIDPKLKTPIERKVYDTLRGPVLIFSSKEAYNAKRDKIEKLNSKGIEIVTINEKEGYLSTKEILNVLKKRGCEKILVVGGGRTNWFFLKEGLVDEFYITVTPYILGNTKYSPVSGSGFPFPGIKLELLSMEKCPCGEEVILKYKVHNNLQNILDKINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1J3</accession>
    <name>I0A1J3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="1">5.3.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_0862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH42850">
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        <property type="gene ID" value="FFONT_0862"/>
    </dbReference>
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    <dbReference type="eggNOG" id="arCOG01122">
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    </dbReference>
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        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
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    <dbReference type="PANTHER" id="PTHR11934">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00021">
        <property type="entry name" value="rpiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH42850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="233" mass="25484" checksum="ECD3762A23BB4514" modified="2012-06-13" version="1">MQKEEEKKIAASIATNLEEVKKAKVIGIGTGSTTSYFIDYLPEDILKGKVFVTSSFDSTLRLKQKGAKVLSIDSIESIDIYIDGVDAIDDNGTAIKGGGAALFREKLLASMSKYFVAIADTSKLKKELNNSFIPIEVKPEAVNYVIKKLKDIGVIGNVRYSKEGKWGPVISDSYGVIVDIQIKNWKISLEELNNTLKSITGVVETGLFIGMIDALIVGGEPPIVKQFYRKGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1K6</accession>
    <name>I0A1K6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase</fullName>
            <ecNumber evidence="5">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FFONT_0875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="5"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0875"/>
    <dbReference type="EnsemblBacteria" id="AFH42863">
        <property type="protein sequence ID" value="AFH42863"/>
        <property type="gene ID" value="FFONT_0875"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0875"/>
    <dbReference type="eggNOG" id="arCOG15272">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_6_0_2"/>
    <dbReference type="OMA" id="WIRNMLY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="8">
        <location>
            <begin position="147"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="7">
        <location>
            <begin position="519"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH42863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="938" mass="108209" checksum="825BE81AA78C3756" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1L6</accession>
    <name>I0A1L6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-oxoacid oxidoreductase (ferredoxin)</fullName>
            <ecNumber evidence="3">1.2.7.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0885</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + CoA + 2 oxidized [2Fe-2S]-[ferredoxin] = an acyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:42316"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="EC" id="1.2.7.11"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer composed of an alpha and a beta subunit.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.11" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0885"/>
    <dbReference type="EnsemblBacteria" id="AFH42873">
        <property type="protein sequence ID" value="AFH42873"/>
        <property type="gene ID" value="FFONT_0885"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0885"/>
    <dbReference type="eggNOG" id="arCOG01052">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_0_2"/>
    <dbReference type="OMA" id="SEAYYMA"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018491">
        <property type="term" value="F:2-oxobutyrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019164">
        <property type="term" value="F:pyruvate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="4">
        <location>
            <begin position="13"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="336" mass="36816" checksum="32496A6A40612367" modified="2012-06-13" version="1">MELGVSEMSERVITFREAINEALDQEMQENAKVILIGEDIGRYGGIFGVTKRLIDKYGEERVRDAPTAESGFIGAAIGAAMMGYRPVVELMFIDFIGVAFDQIINQAAKIRYMSGGGISVPIVIRTVSGAGFSGGAQHSQSLHSILLHIPGLKVVMPSNPFDAKGLLISSIEDDDPVVFIEHKGLYETRGVVPKEKYSIPLGVADIKKAGKDVTVIATAVMLHKTLSVVEKLREEGISVEVIDPRSLRPLDTETIANSVKKTGRLVVVDESYPRCSFATDIASFIASKYFEYLEAPIKIVTPPDTPVPYSLPLERAWIPNEEKIYDAIKKVIEYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1M4</accession>
    <name>I0A1M4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_0893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0893"/>
    <dbReference type="EnsemblBacteria" id="AFH42881">
        <property type="protein sequence ID" value="AFH42881"/>
        <property type="gene ID" value="FFONT_0893"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0893"/>
    <dbReference type="HOGENOM" id="CLU_1933178_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH42881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="130" mass="14829" checksum="11601BB7CBA90085" modified="2012-06-13" version="1">MKSVKVGFLIASLFVLFLFLLPLILFSIDALTNKNLISYSYEIVDSETPHLDFKLNYNGDIYLTDFNITINASNESFNFYAEKVLPNSSLNFSIPLNASNLKELEQFNIKSYTLSFKIMGLYLINTGVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1P6</accession>
    <name>I0A1P6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">NMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_0915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>ATP + beta-nicotinamide D-ribonucleotide + H(+) = diphosphate + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21360"/>
            <dbReference type="ChEBI" id="CHEBI:14649"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="EC" id="2.7.7.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the archaeal NMN adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.1" evidence="3"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH42903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_0915"/>
    <dbReference type="EnsemblBacteria" id="AFH42903">
        <property type="protein sequence ID" value="AFH42903"/>
        <property type="gene ID" value="FFONT_0915"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_0915"/>
    <dbReference type="eggNOG" id="arCOG00972">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108783_0_0_2"/>
    <dbReference type="OMA" id="RFQPFHY"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00600"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000309">
        <property type="term" value="F:nicotinamide-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00243">
        <property type="entry name" value="NMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006418">
        <property type="entry name" value="NMN_Atrans_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CTP_transf_like" evidence="4">
        <location>
            <begin position="8"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH42903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="187" mass="21482" checksum="B5E9CFDA6EDF4016" modified="2012-06-13" version="1">MKFPRRAIFFGRFQPFHKGHLYVAENILKEYEEIVFLVGMSTESHTERNPFTAGERIEMIRLAMKEAGFDLSRVITSALPTLEIHIASAHHAIYASPHSEAIFIGNPIVSQILREAGFNVIVPKPYKREIYNGTLIRRYMAEQNDKWRELVPKSVAEFLDSIKATERLKNITSPSERHILGEENSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1R1</accession>
    <name>I0A1R1_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Archaeal flagellar protein FlaJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">FFONT_0930</name>
    </gene>
    <organism evidence="8 9">
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    <reference evidence="9" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
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            <begin position="474"/>
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</entry>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
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                <person name="Mardanov A.V."/>
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                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <dbReference type="EMBL" id="AFH42947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
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            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="157" mass="17672" checksum="014A2FE7EA0255B5" modified="2012-06-13" version="1">MVEIVVGLHDISSTYRLSDFFKTVQAYKKFINTFAISRVTGAAAQYGIAEISKALFKSNVNFLILQDIGDFLQFFQGYKIFQFTQAYGVEFKSLEQLGLKDNDRILLIFSGNDVGFGKNELLPNATYLKISGIEKELPPQVEFGIFMSMLAKNILIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1U5</accession>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
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        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
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                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.</text>
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    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + H(+) + S-adenosyl-L-homocysteine</text>
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            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
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            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TYW3 family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="gene ID" value="FFONT_0964"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Taw3"/>
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        <property type="entry name" value="tRNA_yW-synthesising"/>
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        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
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        <location>
            <begin position="13"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
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    </evidence>
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        <source>
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        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH42952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="201" mass="23210" checksum="EE30769FEFECFE52" modified="2012-06-13" version="1">MLVADVNVWKNKKTMFIKRIESDREIGYLDPGIDETLSLINKREKSYTTSSCSGRISIVDTDYLWKRNELPLIFKKHSEVSSEELISIFKKEPMNTFWLIVSGPILHVRTLDIEEALFILNAGREAGFKHSGIMSYSEDGYLVELISGTQFNFPIKNKNGYLINIEKIDYIAKLANSALVDGRRKLEKLNQFLKEKENEIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A1W1</accession>
    <name>I0A1W1_FERFK</name>
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        <submittedName>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
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            <authorList>
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                <person name="Mardanov A.V."/>
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                <person name="Beletsky A.V."/>
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                <person name="Bidzhieva S.Kh."/>
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    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="54"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="212" mass="24168" checksum="7CC26E83DEF1615E" modified="2012-06-13" version="1">MTSFNKKMLEITIEKIKGPKNPKPQLEQHMTPSNIASETIWFALQHGLIINKKILDIGSGTGRLCLGSLIAGANECVSIEIDDEEIEEQIKYAKKLGIECKVEIIKADGASVPLRDSSLDVTLMNPPFGSVKRGIDWKFLKEALRVTRAVLSFHMYSEKSKDFFFKKVGEFGYKIEILKVYNMELKQIFEYHVSRKKKIPVMLLFIIKGEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>I0A294</accession>
    <name>I0A294_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="3">rRNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">FFONT_1113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1113"/>
    <dbReference type="EnsemblBacteria" id="AFH43101">
        <property type="protein sequence ID" value="AFH43101"/>
        <property type="gene ID" value="FFONT_1113"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1113"/>
    <dbReference type="eggNOG" id="arCOG01018">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056931_3_0_2"/>
    <dbReference type="OMA" id="PIMNLSH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="236" mass="26662" checksum="81D66BD552B2CE39" modified="2012-06-13" version="1">MDIRLVLVGIEGGANLGMIMRLAENFEVDDVVLVYPRELDMDEARRFSAKAVGRLDNLVVYKNLDEALSPCDVRVCTTAKFSLDGDILRSTIPSYDLPSFLERYKKPCIVFGRESSGLTRDELSKCDFVSTIPSSSEYSALNLANSVSIYLYEIYKSKRKRDLVNLAEREELEQAVSIFGDIASMALGDETKIMRARTAMRHVLFRSSPSKPEVRILTHVLRRVKRRIEGSSTKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2C8</accession>
    <name>I0A2C8_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CCA-adding enzyme</fullName>
            <ecNumber evidence="8">2.7.7.72</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCA tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA CCA-pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA adenylyl-/cytidylyl- transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">tRNA-NT</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cca</name>
        <name evidence="11" type="ordered locus">FFONT_1147</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a tRNA precursor + ATP + 2 CTP = a tRNA with a 3' CCA end + 3 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14433"/>
            <dbReference type="Rhea" id="RHEA-COMP:10465"/>
            <dbReference type="Rhea" id="RHEA-COMP:10468"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:83071"/>
            <dbReference type="EC" id="2.7.7.72"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">A single active site specifically recognizes both ATP and CTP and is responsible for their addition.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.72" evidence="8"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1147"/>
    <dbReference type="EnsemblBacteria" id="AFH43135">
        <property type="protein sequence ID" value="AFH43135"/>
        <property type="gene ID" value="FFONT_1147"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1147"/>
    <dbReference type="eggNOG" id="arCOG04249">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044679_1_0_2"/>
    <dbReference type="OMA" id="DVDLVPC"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052928">
        <property type="term" value="F:CTP:3'-cytidine-tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CTP:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016437">
        <property type="term" value="F:tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042245">
        <property type="term" value="P:RNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05400">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01264">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008229">
        <property type="entry name" value="CCA-adding_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042090">
        <property type="entry name" value="CCA_tRNA_nucleotrans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006116">
        <property type="entry name" value="NT_2-5OAS_ClassI-CCAase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015329">
        <property type="entry name" value="tRNA_NucTransf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39643">
        <property type="entry name" value="PTHR39643"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09249">
        <property type="entry name" value="tRNA_NucTransf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005335">
        <property type="entry name" value="CCA_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="SSF55003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03671">
        <property type="entry name" value="cca_archaeal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0692">RNA repair</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="9">
        <location>
            <begin position="34"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA_NucTransf2" evidence="10">
        <location>
            <begin position="154"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AFH43135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="485" mass="56157" checksum="CA9E88BECB7852B2" modified="2012-06-13" version="1">MTLSSIEVEILKKIKPTDEDRAKANAIFNIVKNKIIEGLKASNEKFEVLLEGSIAKDTWLRTSPEMDVFIVFENELDKKDFESIVNKLASILNEYEPAKQYAEHPYLTIKVDEYNVDIVPAIKYEKGKRTKTAVDRTPLHTLFILENTTPELRDEIRVAKKFARSIGVYGAETKIEGFSGYLIELLTIKYGGFRELLNKASEWRIPIKISFSSSESIKRLLSKYENCPMIVEDPTDSERNVAAAVSKRKIFEFSSASKLYLKKPTLYFFEEDNDEKVISTINFESLEPYYKNVVIIEFEIRKEISKDVIWGELKRMSKNAFNILKNEGFDVVKCEPWSDEKKEAYIACLLTSIFLPSKNVSIGPPMFFKEHFFAFINEHILRPVEGPWIGDDGRLWSLNERKFLNALQLLLERKKEIAISDFADSLVDMYILSWRTEKLSGKRGVWLKTFIMNKPKWIMPYYLSIFEEKISSLKSSKYSDTIKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2D4</accession>
    <name>I0A2D4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine synthase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1153"/>
    <dbReference type="EnsemblBacteria" id="AFH43141">
        <property type="protein sequence ID" value="AFH43141"/>
        <property type="gene ID" value="FFONT_1153"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1153"/>
    <dbReference type="eggNOG" id="arCOG01430">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2613443_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="1">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="78" mass="8550" checksum="451EBEB605877E29" modified="2012-06-13" version="1">MVSSAIKEHNLKLGEYIVEASSGNTAIYVAFVARKLGLNPIIVVSRQTSVAKVKLIKILGAEIFYGSDDKDADDYYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2E5</accession>
    <name>I0A2E5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Stomatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">FFONT_1164</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1164"/>
    <dbReference type="EnsemblBacteria" id="AFH43152">
        <property type="protein sequence ID" value="AFH43152"/>
        <property type="gene ID" value="FFONT_1164"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1164"/>
    <dbReference type="eggNOG" id="arCOG01915">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_3_2"/>
    <dbReference type="OMA" id="NAVLYFR"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="26"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFH43152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="282" mass="31425" checksum="03685AE0D212D339" modified="2012-06-13" version="1">MDAYTLVSNLTTIIFIIIILIIFLSMAIKVVREYERAVVFRLGRLLGAKGPGLFFIIPFVDRLLKVDLRIVAVDVPEQRSVTRDNVSVGVDAVIYYKVLDPVKAIMAVENYSYAVLMLAQTTLRDVIGQVELDDLLSKREELNKRIQGILDVLTDPWGIKVTAVTLKEVKLPDTMLRALAKQAEAERFRRARIIEAEGERQSASIMSEAATFYESHPMAMRLRELQTLIEIAREKNLIIVTPESRGEILGTVVGLTKGIQVGGKETSTSSPMKASSESESET</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2H0</accession>
    <name>I0A2H0_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SPP-like hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1189"/>
    <dbReference type="EnsemblBacteria" id="AFH43177">
        <property type="protein sequence ID" value="AFH43177"/>
        <property type="gene ID" value="FFONT_1189"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1189"/>
    <dbReference type="eggNOG" id="arCOG01213">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044146_2_0_2"/>
    <dbReference type="OMA" id="DTGYAYH"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="264" mass="29719" checksum="10D140B9239C89CF" modified="2012-06-13" version="1">MDNLKRGVELINKLANIDSIATDVDGTITANRDGYFIPSEVIECIREIRKYNIMLIFVSANAFPVLYGLARYIGAKAIVSENGCIIASLNEHGREMNIYEICGRGYRELVSKIVSEMGDFLKESWQNDYRKYDFALIQKDNRVSHIELIQKIKKIVIKNGYDSKVNVNYSGYAFHITPKEGGKSVGLKKISEILGIELKNTLGIGDSYMDLEFIQLTGVKVAVRNADEDLKRNVDIITDEESGYGFAQICETIIDAKKLKLQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2H9</accession>
    <name>I0A2H9_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="8">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thrS</name>
        <name evidence="10" type="ordered locus">FFONT_1198</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1198"/>
    <dbReference type="EnsemblBacteria" id="AFH43186">
        <property type="protein sequence ID" value="AFH43186"/>
        <property type="gene ID" value="FFONT_1198"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1198"/>
    <dbReference type="eggNOG" id="arCOG00401">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="eggNOG" id="arCOG01254">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_2"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="241"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="514"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AFH43186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="657" mass="75544" checksum="61C81287955C90DE" modified="2012-06-13" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2L9</accession>
    <name>I0A2L9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1238"/>
    <dbReference type="EnsemblBacteria" id="AFH43226">
        <property type="protein sequence ID" value="AFH43226"/>
        <property type="gene ID" value="FFONT_1238"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1238"/>
    <dbReference type="eggNOG" id="arCOG00755">
        <property type="taxonomic scope" value="Archaea"/>
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    <dbReference type="HOGENOM" id="CLU_007884_4_1_2"/>
    <dbReference type="OMA" id="PDHNALI"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="10"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="387" mass="43211" checksum="74AE9508B066B94F" modified="2012-06-13" version="1">MIYLNCKNSIIGGGVVGLSVAMNLAIANGKGNDICLFESKYLGYGSSLRNAGRFRVHFGDENNLEFAVESSKYLNSLSKITGMNVLFAKTGYLWIASDEASYNILKNANSTFKKWGVPLTEIPSEELYKKYKFLRKRNEIISGFLGKEDGTIHPDSVIFGMARKCKSLKVNIFEHSNVEDISIRSGKVESIKVNGSKVETERVIIANGAWMTFFSEKLGLNLPIEPVRKEISVTEPFAYRIEPFIVDSSLHTYVSQTLKGEIIGSTSTGAEPKGLVELGNSFLWLKKYAERLSRILAGAERIRIIRAWSGYYEMTPDRSHVVGRSNDWPEELYVIGGFSGHGFMLGPLAGKLMAEYIFTGTMPRLLRPYSPERFKTGKLINETFVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2P5</accession>
    <name>I0A2P5_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative signal recognition particle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1264</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1264"/>
    <dbReference type="EnsemblBacteria" id="AFH43252">
        <property type="protein sequence ID" value="AFH43252"/>
        <property type="gene ID" value="FFONT_1264"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1264"/>
    <dbReference type="eggNOG" id="arCOG01227">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_4_2"/>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
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    </dbReference>
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        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="5">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="307" mass="34174" checksum="840A5BD3C2FC5A0B" modified="2012-06-13" version="1">MFSRLKKSIESFSNSLAEKFKTKEIKPEDFDEIGNDFLLELVENDVAYSVAEEIINTLKNTIIGKRVPKNSDIKESIKEALVDFIKKNIPEPDLDIIEAIKNKQAKEKKPFIIIFMGINGVGKTTSIAKLANYIKKNGMTPLIVAADTFRAGSQEQLQVHADRLGVPIIRAKYNSDPASIAFDGIAYAEKKNIPVVLIDTAGRMHVDRDLINELKKIIDVVGYDLRLLVIDALSGNDSVEQAIAYEKNVGYEGFFLTKSDADTKGGVALSISVETKKPIYFLGTGQNYDDIVPFNKEWLIKTLLGEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2T4</accession>
    <name>I0A2T4_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cluster: Integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">FFONT_1303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1303"/>
    <dbReference type="EnsemblBacteria" id="AFH43291">
        <property type="protein sequence ID" value="AFH43291"/>
        <property type="gene ID" value="FFONT_1303"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1303"/>
    <dbReference type="eggNOG" id="arCOG01994">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099320_0_0_2"/>
    <dbReference type="OMA" id="IIPHGIV"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002798">
        <property type="entry name" value="SpoIIM-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01944">
        <property type="entry name" value="SpoIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="196" mass="21263" checksum="C053A107413539A9" modified="2012-06-13" version="1">MKLSLKKLMALMIFLFLIGGILGYLIVLSGQSDLISQLIGGVGEKAKTINFKPFSPSSVLAIFVNNLTVSLISILSGLTVVIPSFIVLANGIITGLVVGLLTQEGLSVFSGILSLMPHGIFELTAIFLSAAYGTSLGVNFWKFMFRRENNFFDVLKKMPKYVLNIVILLLIAAVIEVFISPLVLQFLLNSKTPVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-01-19" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2U3</accession>
    <name>I0A2U3_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoate--protein ligase</fullName>
            <ecNumber evidence="4">6.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">FFONT_1312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-lipoate + ATP + L-lysyl-[lipoyl-carrier protein] = (R)-N(6)-lipoyl-L-lysyl-[lipoyl-carrier protein] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10500"/>
            <dbReference type="Rhea" id="RHEA-COMP:10502"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.20" evidence="4"/>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1312"/>
    <dbReference type="EnsemblBacteria" id="AFH43300">
        <property type="protein sequence ID" value="AFH43300"/>
        <property type="gene ID" value="FFONT_1312"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1312"/>
    <dbReference type="eggNOG" id="arCOG03837">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2406216_0_0_2"/>
    <dbReference type="OMA" id="PKEDIWI"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00594"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016979">
        <property type="term" value="F:lipoate-protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019491">
        <property type="entry name" value="Lipoate_protein_ligase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10437">
        <property type="entry name" value="Lip_prot_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lip_prot_lig_C" evidence="8">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AFH43300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="92" mass="10618" checksum="6A06973C5868ABB0" modified="2012-06-13" version="1">MRETYSEYKAKKGLLKSRVLLSDDDKIEKIEITGDFFIYPEEFLWILEERLKGTKFDENAVKEVVTKLIDELSAEFVGMTPDDLVRAIIGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2U6</accession>
    <name>I0A2U6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">FFONT_1315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000007391">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFH43303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="41" mass="4867" checksum="F178B2EAF55CEACC" modified="2012-06-13" version="1">MRVRTEHKAIELFQRSRKVSELLSFLQMKDVNTNRCGEEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
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            <fullName evidence="3">Electron-transferring-flavoproteindehydrogenase</fullName>
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        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
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        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_1320"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="FAD/NAD-bd_sf"/>
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        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039651">
        <property type="entry name" value="FixC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43624">
        <property type="entry name" value="PTHR43624"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="2">
        <location>
            <begin position="8"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="424" mass="47194" checksum="AB9B0DC1F2A6F00A" modified="2012-06-13" version="1">MSNSLDFDAIVVGGGPAGATAAYFLAKKGYNTLLLERGKRYGSKNVYGGKIYSYYVKKLFPEFEKEAPIQRWVNRERYSITYNDSAVTFEYFSPQAPSFTAYLSDFTNWLCKKAEQQGATVISESKATGLIREGDKIVGIEAGEEKVKADVTIIAEGANRILLEKAGLVRPPDPMQVAVGIKETIKLDQKAINERFNIGDNEGLSWLFLGDVTNGLPDGAFLYTFKDAVSVGAVVTLGTAIDSINEHIYNFAEKLRIHPVMRNLLKDGEIVEYAAHLTVVDVESFIPEKLSGNGYMIIGDAGGLLANMGYTFRGVDFAMYSGYLAAEAYEKIRNNKESWNAFDSMVRSSSMFEEIMRYRKVHEVVKNPKLLTSYPKLLSDLMASKFHIEEKTATFKDAFFETLKKDNVGVVSLLRDLLNMVSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2V5</accession>
    <name>I0A2V5_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0147 protein FFONT_1324</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ordered locus">FFONT_1324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
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            <taxon>Fervidicoccus</taxon>
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    </organism>
    <reference evidence="4" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0147 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="gene ID" value="FFONT_1324"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1324"/>
    <dbReference type="eggNOG" id="arCOG04308">
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    <dbReference type="OMA" id="RTIIWEV"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ta0600-like_sf"/>
    </dbReference>
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        <property type="entry name" value="UPF0147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03685">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFH43312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="92" mass="10220" checksum="C9F087184543D43D" modified="2012-06-13" version="1">MSKMSTANLNEEKIKNAIVMLTKVVNDVSVPRNIRRVATDAINKLKDPSLSPGVRAANAIQVLDEISQDPNMPVHTRITIWNIVSLLETVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2X6</accession>
    <name>I0A2X6_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ordered locus">FFONT_1345</name>
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    <organism evidence="2 3">
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        <lineage>
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    <reference evidence="3" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
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                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP003423">
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    </dbReference>
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    <dbReference type="EnsemblBacteria" id="AFH43333">
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        <property type="gene ID" value="FFONT_1345"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1345"/>
    <dbReference type="HOGENOM" id="CLU_2299226_0_0_2"/>
    <dbReference type="Proteomes" id="UP000007391">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFH43333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="100" mass="11191" checksum="488DCEC49DA360F3" modified="2012-06-13" version="1">MEKILVESVSSVEDNIRKSKSDTSFLSVELNLDEKEEVLKASFDVEVISAVRTPFGPEDKAGRIADGLKRSLEEKISELRFKRTDKKGSREKEGNSDSNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2X9</accession>
    <name>I0A2X9_FERFK</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">FFONT_1348</name>
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    <organism evidence="7 8">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
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        <lineage>
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            <taxon>Fervidicoccus</taxon>
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    <reference evidence="8" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1348"/>
    <dbReference type="EnsemblBacteria" id="AFH43336">
        <property type="protein sequence ID" value="AFH43336"/>
        <property type="gene ID" value="FFONT_1348"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1348"/>
    <dbReference type="eggNOG" id="arCOG01557">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147805_1_0_2"/>
    <dbReference type="OMA" id="YGYRYAK"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFH43336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="128" mass="14587" checksum="E5E7A033E2E5A962" modified="2012-06-13" version="1">MTITAIFSYGVVPALLLFFLLAVISLLYFVLRKEEKTITGLKDERYEAGNPPKYKARVRVGFQYLGFFILFASFESVVVTFLLLSLSSGAYINKLAEFFLSIVLVSVPILLYGIKEAEKVENWVWDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-06-13" modified="2022-08-03" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>I0A2Z6</accession>
    <name>I0A2Z6_FERFK</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ORC1-type DNA replication protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">FFONT_1365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Fervidicoccus fontis (strain DSM 19380 / JCM 18336 / VKM B-2539 / Kam940)</name>
        <dbReference type="NCBI Taxonomy" id="1163730"/>
        <lineage>
            <taxon>Archaea</taxon>
            <taxon>Crenarchaeota</taxon>
            <taxon>Thermoprotei</taxon>
            <taxon>Fervidicoccales</taxon>
            <taxon>Fervidicoccaceae</taxon>
            <taxon>Fervidicoccus</taxon>
        </lineage>
    </organism>
    <reference evidence="7" key="1">
        <citation type="submission" date="2012-03" db="EMBL/GenBank/DDBJ databases">
            <title>Fervidicoccus fontis complete genome analysis confirms its distinct phylogenetic position and predicts its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Ravin N.V."/>
                <person name="Skryabin K.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2014" name="Extremophiles" volume="18" first="295" last="309">
            <title>Analysis of the complete genome of Fervidococcus fontis confirms the distinct phylogenetic position of the order Fervidicoccales and suggests its environmental function.</title>
            <authorList>
                <person name="Lebedinsky A.V."/>
                <person name="Mardanov A.V."/>
                <person name="Kublanov I.V."/>
                <person name="Gumerov V.M."/>
                <person name="Beletsky A.V."/>
                <person name="Perevalova A.A."/>
                <person name="Bidzhieva S.Kh."/>
                <person name="Bonch-Osmolovskaya E.A."/>
                <person name="Skryabin K.G."/>
                <person name="Ravin N.V."/>
            </authorList>
            <dbReference type="PubMed" id="24366681"/>
            <dbReference type="DOI" id="10.1007/s00792-013-0616-7"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">DSM 19380 / VKM B-2539 / Kam940</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in regulation of DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP003423">
        <property type="protein sequence ID" value="AFH43353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1163730.FFONT_1365"/>
    <dbReference type="EnsemblBacteria" id="AFH43353">
        <property type="protein sequence ID" value="AFH43353"/>
        <property type="gene ID" value="FFONT_1365"/>
    </dbReference>
    <dbReference type="KEGG" id="ffo:FFONT_1365"/>
    <dbReference type="eggNOG" id="arCOG00467">
        <property type="taxonomic scope" value="Archaea"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025112_3_2_2"/>
    <dbReference type="OMA" id="YLFYENE"/>
    <dbReference type="Proteomes" id="UP000007391">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08768">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01407">
        <property type="entry name" value="ORC1_type_DNA_replic_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015163">
        <property type="entry name" value="Cdc6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014277">
        <property type="entry name" value="Orc1/Cdc6_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09079">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01074">
        <property type="entry name" value="Cdc6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02928">
        <property type="entry name" value="TIGR02928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="57"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc6_C" evidence="5">
        <location>
            <begin position="316"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="69"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AFH43353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007391"/>
        </source>
    </evidence>
    <sequence length="407" mass="45937" checksum="A00AE835038E6392" modified="2012-06-13" version="1">MPSVEKIIEDEISSPSVFKEKHKLYPEYTPSSLPHREKQLKQLAQLFKSFFSSPGEEMQRVMLVGSFGTGKTVTSKLFGASASSLASRNGIRLKYVHVNCYKSRTLPQIIYNISLDLGITLPQRGLSAQELMRGLIEELERRNTYAIVALDEFDYFALMSSGLNSIYVLVRAYDEYVNKKKRLHFIFISRSISTLENIDPSSSTYFLKNIVEFSPYTYSELYDILKERADEALYPGVISDDELKYISMIEGYDKGGSGSARTALEILVRAGESADSEKRSSITLDDIRKAHVIVKPELAMLQDQVSALDRHELVLYLSVIKALKGSGSGFVRIGDVEKIYRVLCEAYNLQPRRHTQVYTHILELRSMGFIQTKSSGKGFRGKSTLIGISAAPLYVLESKVEELLKRE</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>