<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2020-02-26" modified="2022-08-03" version="9" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5P8PNA8</accession>
    <name>A0A5P8PNA8_9CIRC</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Replication-associated protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ATP-dependent helicase Rep</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">RepP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rep</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capybara associated cyclovirus 1</name>
        <dbReference type="NCBI Taxonomy" id="2604905"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cressdnaviricota</taxon>
            <taxon>Arfiviricetes</taxon>
            <taxon>Cirlivirales</taxon>
            <taxon>Circoviridae</taxon>
            <taxon>Cyclovirus</taxon>
            <taxon>Capybara associated cyclovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2019-05" db="EMBL/GenBank/DDBJ databases">
            <title>Diverse ssDNA viruses associated with Capybara (Hydrochoerus hydrochaeris) in Brazil.</title>
            <authorList>
                <person name="Fontenele R.S."/>
                <person name="Lamas N.S."/>
                <person name="Lacorte C."/>
                <person name="Varsani A."/>
                <person name="Ribeiro S.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Cap1_365</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nanoviruses/circoviruses replication-associated protein family.</text>
    </comment>
    <dbReference type="EMBL" id="MK947371">
        <property type="protein sequence ID" value="QFR58251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000683057">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016888">
        <property type="term" value="F:endodeoxyribonuclease activity, producing 5'-phosphomonoesters"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018142">
        <property type="term" value="P:protein-DNA covalent cross-linking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000605">
        <property type="entry name" value="Helicase_SF3_ssDNA/RNA_vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003365">
        <property type="entry name" value="Viral_rep_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00910">
        <property type="entry name" value="RNA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02407">
        <property type="entry name" value="Viral_Rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Viral_Rep" evidence="10">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_helicase" evidence="9">
        <location>
            <begin position="163"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QFR58251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000683057"/>
        </source>
    </evidence>
    <sequence length="285" mass="33791" checksum="A90AC82437CD1904" modified="2020-02-26" version="1">MPRVRRRIKRVCFTLNNYTEDDEQRIQQYANDYEYCIYGREIAPSTGTHHLQGFINFKVRREFATIKRIIGNTAHIEPSNGTDVQNKEYCSKGNNIWEYGKPSKQGKRSDLDSVVETIKSARTLADIVSQHPSMYIRYHRGIEKLFGYIGTRQKREWKTYTTILYGESGVGKSRAALEKAQGNVYYKTRGEWWDNYKGEETVIIDDFYGWIKLDEMLRITDRYALQVPVKGGFVEFLAYHIYITSNKEPLEWYKFTNDNLKKAFIRRLDKIYYCTQYYTEKIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2020-02-26" modified="2022-08-03" version="10" xmlns="http://uniprot.org/uniprot">
    <accession>A0A5P8PPN6</accession>
    <name>A0A5P8PPN6_9CIRC</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Capsid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cp</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Capybara associated cyclovirus 1</name>
        <dbReference type="NCBI Taxonomy" id="2604905"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cressdnaviricota</taxon>
            <taxon>Arfiviricetes</taxon>
            <taxon>Cirlivirales</taxon>
            <taxon>Circoviridae</taxon>
            <taxon>Cyclovirus</taxon>
            <taxon>Capybara associated cyclovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="11" key="1">
        <citation type="submission" date="2019-05" db="EMBL/GenBank/DDBJ databases">
            <title>Diverse ssDNA viruses associated with Capybara (Hydrochoerus hydrochaeris) in Brazil.</title>
            <authorList>
                <person name="Fontenele R.S."/>
                <person name="Lamas N.S."/>
                <person name="Lacorte C."/>
                <person name="Varsani A."/>
                <person name="Ribeiro S.G."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">Cap1_365</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the circoviridae capsid protein family.</text>
    </comment>
    <dbReference type="EMBL" id="MK947371">
        <property type="protein sequence ID" value="QFR58250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000683057">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039615">
        <property type="term" value="C:T=1 icosahedral viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019069">
        <property type="term" value="P:viral capsid assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075732">
        <property type="term" value="P:viral penetration into host nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019062">
        <property type="term" value="P:virion attachment to host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003383">
        <property type="entry name" value="Circovirus_capsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038652">
        <property type="entry name" value="Circovirus_capsid_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02443">
        <property type="entry name" value="Circo_capsid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="9" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1140">T=1 icosahedral capsid protein</keyword>
    <keyword evidence="9" id="KW-1161">Viral attachment to host cell</keyword>
    <keyword evidence="8" id="KW-1162">Viral penetration into host cytoplasm</keyword>
    <keyword evidence="6" id="KW-1163">Viral penetration into host nucleus</keyword>
    <keyword evidence="10" id="KW-0946">Virion</keyword>
    <keyword evidence="9" id="KW-1160">Virus entry into host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QFR58250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000683057"/>
        </source>
    </evidence>
    <sequence length="228" mass="26301" checksum="9C009B84840CE06A" modified="2020-02-26" version="1">MYGSRRFKGRRTRLPWRRSRFVRRRRGRFSRRTRRNYRRHTGNLVVLGRTTLKIVPNATTETTTIVQPMIDDFKEFDNFKYNFEMYKMLSVRIKVTPVNNIQDGQINGAIYWTAPWKRPVNTPAGFTAEAIQSLDKARSHHICSTMTRHFVPAIQNVVAINGTGEASSNLTNSQIIFKPWISVIEDAALTIRHHCGLVNFPAMPTTNAFTLTVTAKVMFKNQKNSQLN</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>