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<entry dataset="TrEMBL" created="2017-06-07" modified="2022-05-25" version="12" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1V0JHV5</accession>
    <name>A0A1V0JHV5_9VIRU</name>
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        <submittedName>
            <fullName evidence="3">ORF0</fullName>
        </submittedName>
    </protein>
    <organism evidence="3 4">
        <name type="scientific">Tobacco virus 2</name>
        <dbReference type="NCBI Taxonomy" id="1972995"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Pisuviricota</taxon>
            <taxon>Pisoniviricetes</taxon>
            <taxon>Sobelivirales</taxon>
            <taxon>Solemoviridae</taxon>
            <taxon>Polerovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2017" name="Arch. Virol." volume="162" first="2159" last="2162">
            <title>Sequencing and phylogenetic analysis of tobacco virus 2, a polerovirus from Nicotiana tabacum.</title>
            <authorList>
                <person name="Zhou B."/>
                <person name="Wang F."/>
                <person name="Zhang X."/>
                <person name="Zhang L."/>
                <person name="Lin H."/>
            </authorList>
            <dbReference type="PubMed" id="28342033"/>
            <dbReference type="DOI" id="10.1007/s00705-017-3339-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">TV2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KY038943">
        <property type="protein sequence ID" value="ARD08873.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000202933">
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    </dbReference>
    <dbReference type="GO" id="GO:0016021">
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        <property type="entry name" value="Virus_P0"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04662">
        <property type="entry name" value="Luteo_PO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0941">Suppressor of RNA silencing</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="21"/>
            <end position="43"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ARD08873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000202933"/>
        </source>
    </evidence>
    <sequence length="247" mass="28201" checksum="9E8DE6F74EBAB96D" modified="2017-06-07" version="1">MFVLTPTGSIAFDETKKLTKLVFVNLVIGFPTLLAQAHILFHYNYEQIYNISRSVFYLLPLLSRCKGWISSSGLSISRHWHSQCLKWGLLCGTHPAIQIGHTSLTIKIGEPSTAAAYRRELSRIDSNSYVQNARGLYNSWGQDMATFVKNAVCFLEIRKRCYPKRGLNATLDYNFNLVRSLLDACQDTGHLFVDVQYTVLLHNLAVFYNQLDFQGCEILFRELTGLPIYVPSEAYLEGSFLQKELQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1V0JHV7</accession>
    <name>A0A1V0JHV7_9VIRU</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ORF3</fullName>
        </submittedName>
    </protein>
    <organism evidence="4 5">
        <name type="scientific">Tobacco virus 2</name>
        <dbReference type="NCBI Taxonomy" id="1972995"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Pisuviricota</taxon>
            <taxon>Pisoniviricetes</taxon>
            <taxon>Sobelivirales</taxon>
            <taxon>Solemoviridae</taxon>
            <taxon>Polerovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2017" name="Arch. Virol." volume="162" first="2159" last="2162">
            <title>Sequencing and phylogenetic analysis of tobacco virus 2, a polerovirus from Nicotiana tabacum.</title>
            <authorList>
                <person name="Zhou B."/>
                <person name="Wang F."/>
                <person name="Zhang X."/>
                <person name="Zhang L."/>
                <person name="Lin H."/>
            </authorList>
            <dbReference type="PubMed" id="28342033"/>
            <dbReference type="DOI" id="10.1007/s00705-017-3339-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">TV2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KY038943">
        <property type="protein sequence ID" value="ARD08876.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="SMR" id="A0A1V0JHV7"/>
    <dbReference type="Proteomes" id="UP000202933">
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    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
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        <property type="project" value="InterPro"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029053">
        <property type="entry name" value="Viral_coat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00894">
        <property type="entry name" value="Luteo_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00915">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <end position="62"/>
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            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ARD08876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000202933"/>
        </source>
    </evidence>
    <sequence length="208" mass="23153" checksum="E3A35A7DA37571CD" modified="2017-06-07" version="1">MSTVVVKGNVNGGVQQPRMRRRQSLRRRANRVQPVVMVTAPGQPRRRRRRRGGNRRSRRTGVPRGRGSSETFVFTKDNLVGNTQGSFTFGPSLSDCPAFKDGILKAYHEYKITSILLQFVSEASSTSSGSIAYELDPHCKVSSLQSYVNKFQITKGGAKTYQARMINGVEWHDSSEDQCRILWKGNGKSSDSAGSFRVTIKVALQNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="14" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1V0JHV8</accession>
    <name>A0A1V0JHV8_9VIRU</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ORF4</fullName>
        </submittedName>
    </protein>
    <organism evidence="7 8">
        <name type="scientific">Tobacco virus 2</name>
        <dbReference type="NCBI Taxonomy" id="1972995"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Pisuviricota</taxon>
            <taxon>Pisoniviricetes</taxon>
            <taxon>Sobelivirales</taxon>
            <taxon>Solemoviridae</taxon>
            <taxon>Polerovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2017" name="Arch. Virol." volume="162" first="2159" last="2162">
            <title>Sequencing and phylogenetic analysis of tobacco virus 2, a polerovirus from Nicotiana tabacum.</title>
            <authorList>
                <person name="Zhou B."/>
                <person name="Wang F."/>
                <person name="Zhang X."/>
                <person name="Zhang L."/>
                <person name="Lin H."/>
            </authorList>
            <dbReference type="PubMed" id="28342033"/>
            <dbReference type="DOI" id="10.1007/s00705-017-3339-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">TV2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host cell junction</location>
            <location evidence="2">Host plasmodesma</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polerovirus movement protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KY038943">
        <property type="protein sequence ID" value="ARD08877.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000202933">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044219">
        <property type="term" value="C:host cell plasmodesma"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001964">
        <property type="entry name" value="Luteo_VPG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01659">
        <property type="entry name" value="Luteo_Vpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00912">
        <property type="entry name" value="LVIRUSORF5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1031">Host cell junction</keyword>
    <keyword evidence="4" id="KW-1040">Host Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ARD08877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000202933"/>
        </source>
    </evidence>
    <sequence length="156" mass="17427" checksum="8A4C6791DC266B05" modified="2017-06-07" version="1">MSMVVYNNQECEEGNPFAGALTEFSQWLWSRPLGNPGAEDAEEEAIAAQEELEFPEDEAQARHSCLQRTTSWATPKEVSPSGRVYQTVRHSRMEYSRPTMSIRSQASYFSSSARPLPPPPVPSLMSWTPIAKYHPSSPTSTSSKLRRAAPKLIKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1V0JHV9</accession>
    <name>A0A1V0JHV9_9VIRU</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ORF1</fullName>
        </submittedName>
    </protein>
    <organism evidence="8 9">
        <name type="scientific">Tobacco virus 2</name>
        <dbReference type="NCBI Taxonomy" id="1972995"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Pisuviricota</taxon>
            <taxon>Pisoniviricetes</taxon>
            <taxon>Sobelivirales</taxon>
            <taxon>Solemoviridae</taxon>
            <taxon>Polerovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2017" name="Arch. Virol." volume="162" first="2159" last="2162">
            <title>Sequencing and phylogenetic analysis of tobacco virus 2, a polerovirus from Nicotiana tabacum.</title>
            <authorList>
                <person name="Zhou B."/>
                <person name="Wang F."/>
                <person name="Zhang X."/>
                <person name="Zhang L."/>
                <person name="Lin H."/>
            </authorList>
            <dbReference type="PubMed" id="28342033"/>
            <dbReference type="DOI" id="10.1007/s00705-017-3339-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">TV2</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KY038943">
        <property type="protein sequence ID" value="ARD08874.1"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016032">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018019">
        <property type="entry name" value="Luteovirus_Orf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043504">
        <property type="entry name" value="Peptidase_S1_PA_chymotrypsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000382">
        <property type="entry name" value="Peptidase_S39B_luteovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02122">
        <property type="entry name" value="Peptidase_S39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00913">
        <property type="entry name" value="LVIRUSORF2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51868">
        <property type="entry name" value="PEPTIDASE_S39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0688">Ribosomal frameshifting</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S39" evidence="7">
        <location>
            <begin position="207"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="439"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="541"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="439"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ARD08874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000202933"/>
        </source>
    </evidence>
    <sequence length="636" mass="69468" checksum="6C8EFA2140EBABCE" modified="2017-06-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-01-19" version="17" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1V0JHW1</accession>
    <name>A0A1V0JHW1_9VIRU</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF5</fullName>
        </submittedName>
    </protein>
    <organism evidence="2 3">
        <name type="scientific">Tobacco virus 2</name>
        <dbReference type="NCBI Taxonomy" id="1972995"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Pisuviricota</taxon>
            <taxon>Pisoniviricetes</taxon>
            <taxon>Sobelivirales</taxon>
            <taxon>Solemoviridae</taxon>
            <taxon>Polerovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2017" name="Arch. Virol." volume="162" first="2159" last="2162">
            <title>Sequencing and phylogenetic analysis of tobacco virus 2, a polerovirus from Nicotiana tabacum.</title>
            <authorList>
                <person name="Zhou B."/>
                <person name="Wang F."/>
                <person name="Zhang X."/>
                <person name="Zhang L."/>
                <person name="Lin H."/>
            </authorList>
            <dbReference type="PubMed" id="28342033"/>
            <dbReference type="DOI" id="10.1007/s00705-017-3339-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">TV2</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KY038943">
        <property type="protein sequence ID" value="ARD08878.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000202933">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002929">
        <property type="entry name" value="PLrV_ORF5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01690">
        <property type="entry name" value="PLRV_ORF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ARD08878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000202933"/>
        </source>
    </evidence>
    <sequence length="476" mass="53162" checksum="3274F23AE0353A43" modified="2017-06-07" version="1">MLTIQARENDDQIILGSLGSQRMKYIEDENQNYTKFSSEYYSQSSMQAVPMYYFNVPKGQWSVDISCEGYQPTSSTSDPNRGRSDGMIAYSNADSDYWNVGEADGVKISKLRNDNTYRQGHPELEINSCHFREGQLLERDATISFHVEAPTDGRFFLVGPAIQKTAKYNYTISYGDWTDRDMELGLITVVLDEHLEGTGSANRVRRPPREGHTYMASPHEPEGKPVGNKPRDETPIQTQERQPDQTPSDDVSDAGSVNSGGPTESLRLEFGVNSDSTYDATVDGTDWPRIPPPRHPPEPRVSGNSRTVTDFSSKADLLENWDAEHFDPGYSKEDVAAATIIAHGSIQDGRSMLEKREENVKNKTSSWKPPSLKAVSPAIAKLRSIRKSQPLEGGTLNKDATDGVSSIGSGSLTGGTLKRKATIEERLLQTLTTEQRLWYENFKKTNPPAATQWLFEYQPPPQVDRNIAEKPFQGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2017-06-07" modified="2022-08-03" version="15" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1V0JHW2</accession>
    <name>A0A1V0JHW2_9VIRU</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RNA-directed RNA polymerase</fullName>
            <ecNumber evidence="13">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15 16">
        <name type="scientific">Tobacco virus 2</name>
        <dbReference type="NCBI Taxonomy" id="1972995"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Pisuviricota</taxon>
            <taxon>Pisoniviricetes</taxon>
            <taxon>Sobelivirales</taxon>
            <taxon>Solemoviridae</taxon>
            <taxon>Polerovirus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2017" name="Arch. Virol." volume="162" first="2159" last="2162">
            <title>Sequencing and phylogenetic analysis of tobacco virus 2, a polerovirus from Nicotiana tabacum.</title>
            <authorList>
                <person name="Zhou B."/>
                <person name="Wang F."/>
                <person name="Zhang X."/>
                <person name="Zhang L."/>
                <person name="Lin H."/>
            </authorList>
            <dbReference type="PubMed" id="28342033"/>
            <dbReference type="DOI" id="10.1007/s00705-017-3339-8"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">TV2</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="13"/>
    <dbReference type="EMBL" id="KY038943">
        <property type="protein sequence ID" value="ARD08875.1"/>
        <property type="molecule type" value="Genomic_RNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000202933">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039694">
        <property type="term" value="P:viral RNA genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001795">
        <property type="entry name" value="RNA-dir_pol_luteovirus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007094">
        <property type="entry name" value="RNA-dir_pol_PSvirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02123">
        <property type="entry name" value="RdRP_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00914">
        <property type="entry name" value="LVIRUSRNAPOL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50507">
        <property type="entry name" value="RDRP_SSRNA_POS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 13" id="KW-0693">Viral RNA replication</keyword>
    <feature type="domain" description="RdRp catalytic" evidence="14">
        <location>
            <begin position="113"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ARD08875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000202933"/>
        </source>
    </evidence>
    <sequence length="316" mass="35837" checksum="8C340CB6DB6B858A" modified="2017-06-07" version="1">MSEANFESMTPEELVQEGLCDPIRLFVKGEPHKQSKLDEGRYRLIMSVSLIDQLVARVLFQSQNKKEIALWRSIPSKPGFGLSTDFQTTEFLECLKQEAGAPSMEKLCENYREYLRPTDCSGFDWSVAFWMLEDDMEVRNRLTYNNTELTKRLRAAWLKCIGNSVLCLSDGTLLAQQVPGVQKSGSYNTSSSNSRIRVMAAYHCGADWAVAMGDDALESPHSNLEEYKNLGFKVEVSRELEFCSHIFRTPTLAIPVNTNKMLYKLIHGYNPECGNPEVIANYLAAVLSVLHELRYDPELVARLHKWLAPSATTKEH</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>