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<entry dataset="TrEMBL" created="2010-10-05" modified="2022-01-19" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>D8WJ38</accession>
    <name>D8WJ38_9MONO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-structural protein V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">V/P</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Tuhoko virus 3</name>
        <dbReference type="NCBI Taxonomy" id="798074"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Orthornavirae</taxon>
            <taxon>Negarnaviricota</taxon>
            <taxon>Haploviricotina</taxon>
            <taxon>Monjiviricetes</taxon>
            <taxon>Mononegavirales</taxon>
            <taxon>Paramyxoviridae</taxon>
            <taxon>Rubulavirinae</taxon>
            <taxon>Pararubulavirus</taxon>
            <taxon>Tuhoko pararubulavirus 3</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2010" name="Virology" volume="404" first="106" last="116">
            <title>Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China.</title>
            <authorList>
                <person name="Lau S.K."/>
                <person name="Woo P.C."/>
                <person name="Wong B.H."/>
                <person name="Wong A.Y."/>
                <person name="Tsoi H.W."/>
                <person name="Wang M."/>
                <person name="Lee P."/>
                <person name="Xu H."/>
                <person name="Poon R.W."/>
                <person name="Guo R."/>
                <person name="Li K.S."/>
                <person name="Chan K.H."/>
                <person name="Zheng B.J."/>
                <person name="Yuen K.Y."/>
            </authorList>
            <dbReference type="PubMed" id="20537670"/>
            <dbReference type="DOI" id="10.1016/j.virol.2010.03.049"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the paramyxoviruses V protein family.</text>
    </comment>
    <dbReference type="EMBL" id="GU128082">
        <property type="protein sequence ID" value="ADI80725.1"/>
        <property type="molecule type" value="Viral_cRNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009094076.1">
        <property type="nucleotide sequence ID" value="NC_025350.1"/>
    </dbReference>
    <dbReference type="GeneID" id="20964366"/>
    <dbReference type="KEGG" id="vg:20964366"/>
    <dbReference type="Proteomes" id="UP000162341">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039502">
        <property type="term" value="P:suppression by virus of host type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039554">
        <property type="term" value="P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024279">
        <property type="entry name" value="Paramyx_V_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025909">
        <property type="entry name" value="Soyouz_module"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14313">
        <property type="entry name" value="Soyouz_module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13008">
        <property type="entry name" value="zf-Paramyx-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="8" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="8" id="KW-1090">Inhibition of host innate immune response by virus</keyword>
    <keyword evidence="6" id="KW-1114">Inhibition of host interferon signaling pathway by virus</keyword>
    <keyword evidence="8" id="KW-1089">Inhibition of host MDA5 by virus</keyword>
    <keyword evidence="8" id="KW-1113">Inhibition of host RLR pathway by virus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0691">RNA editing</keyword>
    <keyword evidence="8" id="KW-0899">Viral immunoevasion</keyword>
    <feature type="domain" description="Soyouz_module" evidence="11">
        <location>
            <begin position="4"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="zf-Paramyx-P" evidence="10">
        <location>
            <begin position="186"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ADI80725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000162341"/>
        </source>
    </evidence>
    <sequence length="244" mass="26364" checksum="DDE7D7D6929B14DD" modified="2010-10-05" version="1">MEPTPSDAEISAWIEKGLATAKHFAPNPVSSQSSLGKSTIKKGNTKVLVSSAEQIASSQPAASHTVKVQAQVHPQQPTASQPCTGARPKTKRTATPAPTPSVQQAVKIEPVYEDIVSNPTHQAENAPLIATQSSAKQSLLCTEPLPSQPSSATRCGEQSFKRGRFSSCSTGKRSNSHPGHRREFDLVWGSGKFEVREWCNPTCSPITPIPRRYQCRCGECPRICKQCEGDYQVLESHGGQNDTN</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>