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    <accession>A0A024B543</accession>
    <name>A0A024B543_9POLY</name>
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        <name type="scientific">New Jersey polyomavirus-2013</name>
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            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Sepolyvirales</taxon>
            <taxon>Polyomaviridae</taxon>
            <taxon>Alphapolyomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2014" name="J. Infect. Dis." volume="210" first="1595" last="1599">
            <title>Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy.</title>
            <authorList>
                <person name="Mishra N."/>
                <person name="Pereira M."/>
                <person name="Rhodes R.H."/>
                <person name="An P."/>
                <person name="Pipas J.M."/>
                <person name="Jain K."/>
                <person name="Kapoor A."/>
                <person name="Briese T."/>
                <person name="Faust P.L."/>
                <person name="Lipkin W.I."/>
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            <dbReference type="PubMed" id="24795478"/>
            <dbReference type="DOI" id="10.1093/infdis/jiu250"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5">NJ-PyV-2013</strain>
        </source>
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            <begin position="275"/>
            <end position="297"/>
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            <end position="213"/>
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            <begin position="196"/>
            <end position="211"/>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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            <dbReference type="Proteomes" id="UP000145802"/>
        </source>
    </evidence>
    <sequence length="299" mass="34279" checksum="FBA89A1C6B9F4D5C" modified="2014-07-09" version="1">MEKVLEKSDKEMLIELLGIPRYAYGNFPIMKTAYKRASKIYHPDKGGSSEKMMLLNSLWQKFQEGLIEVRDSEVCQVSFSDCYDSSLLKCCSPKVFHELFLRSPQCLLKGPTSCSCITSCLYNQHRQIKLCGKKRSFLIPMAAPTSERDMQAGAPQYLPMKSLTREQIYTVMSPPSPPPLMKKMKPKVQDTTLSPLLPPQPLPPPLPPKKYPRRSVSLNSPRVRLHPEALLQEEIQRLRESLHQREEEVLKIWMDLILTRKQALRAHHQNKKGKVLIVLLICLLVCLILSVTLYLAIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-07-09" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A024B5E3</accession>
    <name>A0A024B5E3_9POLY</name>
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            <fullName evidence="6">Minor capsid protein VP2</fullName>
        </recommendedName>
        <alternativeName>
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        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">VP2</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">New Jersey polyomavirus-2013</name>
        <dbReference type="NCBI Taxonomy" id="1497391"/>
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            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Sepolyvirales</taxon>
            <taxon>Polyomaviridae</taxon>
            <taxon>Alphapolyomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="J. Infect. Dis." volume="210" first="1595" last="1599">
            <title>Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy.</title>
            <authorList>
                <person name="Mishra N."/>
                <person name="Pereira M."/>
                <person name="Rhodes R.H."/>
                <person name="An P."/>
                <person name="Pipas J.M."/>
                <person name="Jain K."/>
                <person name="Kapoor A."/>
                <person name="Briese T."/>
                <person name="Faust P.L."/>
                <person name="Lipkin W.I."/>
            </authorList>
            <dbReference type="PubMed" id="24795478"/>
            <dbReference type="DOI" id="10.1093/infdis/jiu250"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NJ-PyV-2013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
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        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the polyomaviruses capsid protein VP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KF954417">
        <property type="protein sequence ID" value="AHZ11643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009030018.1">
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    <dbReference type="GO" id="GO:0044167">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001070">
        <property type="entry name" value="Polyoma_coat_VP2"/>
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    <dbReference type="Pfam" id="PF00761">
        <property type="entry name" value="Polyoma_coat2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1038">Host endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-1043">Host membrane</keyword>
    <keyword evidence="8" id="KW-0426">Late protein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1160">Virus entry into host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00004370"/>
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    </evidence>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00004625"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00006444"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022269"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AHZ11643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000145802"/>
        </source>
    </evidence>
    <sequence length="232" mass="25003" checksum="42D3F27D10273852" modified="2014-07-09" version="1">MGGLLSSLVDMIVMATELSAASGLTMEALLTGEALAALETEVFSLMTVEGLSGIEALAQLGWTAEQFSNMAFISTTFSNAIGYGVLFQTVSGISSLISAGIRLGTSVSSVNRHQTEQELETIFGKIAHLIHVNLAFHLNPFNWCESIGGTVPTEFNFLSLDQLSKLGVVIENGRWVIQTTPSFDPMFESGILIERYEPPGGAYQRATPDWMLPLILRLNGASQEKTPVCPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-07-09" modified="2020-08-12" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>A0A024B5E8</accession>
    <name>A0A024B5E8_9POLY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small T antigen</fullName>
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    <organism evidence="4 5">
        <name type="scientific">New Jersey polyomavirus-2013</name>
        <dbReference type="NCBI Taxonomy" id="1497391"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Sepolyvirales</taxon>
            <taxon>Polyomaviridae</taxon>
            <taxon>Alphapolyomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2014" name="J. Infect. Dis." volume="210" first="1595" last="1599">
            <title>Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy.</title>
            <authorList>
                <person name="Mishra N."/>
                <person name="Pereira M."/>
                <person name="Rhodes R.H."/>
                <person name="An P."/>
                <person name="Pipas J.M."/>
                <person name="Jain K."/>
                <person name="Kapoor A."/>
                <person name="Briese T."/>
                <person name="Faust P.L."/>
                <person name="Lipkin W.I."/>
            </authorList>
            <dbReference type="PubMed" id="24795478"/>
            <dbReference type="DOI" id="10.1093/infdis/jiu250"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">NJ-PyV-2013</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="KF954417">
        <property type="protein sequence ID" value="AHZ11648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="GeneID" id="19394661"/>
    <dbReference type="KEGG" id="vg:19394661"/>
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        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
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    </dbReference>
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        <property type="entry name" value="Papo_T_antigensf"/>
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    <dbReference type="Pfam" id="PF02380">
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AHZ11648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000145802"/>
        </source>
    </evidence>
    <sequence length="183" mass="21193" checksum="E9F18BE8F2A388BC" modified="2014-07-09" version="1">MEKVLEKSDKEMLIELLGIPRYAYGNFPIMKTAYKRASKIYHPDKGGSSEKMMLLNSLWQKFQEGLIEVRDSEVCQVSFSDCYDSSLLKCCSPKVFHELFLRSPQCLLKGPTSCSCITSCLYNQHRQIKLCGKKRCLTWGNCFCFSCFILWFGLRETWKTFEIWKHVIAQMPAALLQLSPSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-07-09" modified="2021-09-29" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A024B5J2</accession>
    <name>A0A024B5J2_9POLY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">VP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">VP1</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">New Jersey polyomavirus-2013</name>
        <dbReference type="NCBI Taxonomy" id="1497391"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Sepolyvirales</taxon>
            <taxon>Polyomaviridae</taxon>
            <taxon>Alphapolyomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2014" name="J. Infect. Dis." volume="210" first="1595" last="1599">
            <title>Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy.</title>
            <authorList>
                <person name="Mishra N."/>
                <person name="Pereira M."/>
                <person name="Rhodes R.H."/>
                <person name="An P."/>
                <person name="Pipas J.M."/>
                <person name="Jain K."/>
                <person name="Kapoor A."/>
                <person name="Briese T."/>
                <person name="Faust P.L."/>
                <person name="Lipkin W.I."/>
            </authorList>
            <dbReference type="PubMed" id="24795478"/>
            <dbReference type="DOI" id="10.1093/infdis/jiu250"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">NJ-PyV-2013</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2020" name="MBio" volume="11" first="0" last="0">
            <title>Structural Basis and Evolution of Glycan Receptor Specificities within the Polyomavirus Family.</title>
            <authorList>
                <person name="Stroh L.J."/>
                <person name="Rustmeier N.H."/>
                <person name="Blaum B.S."/>
                <person name="Botsch J."/>
                <person name="Rossler P."/>
                <person name="Wedekink F."/>
                <person name="Lipkin W.I."/>
                <person name="Mishra N."/>
                <person name="Stehle T."/>
            </authorList>
            <dbReference type="PubMed" id="32723915"/>
            <dbReference type="DOI" id="10.1128/mbio.00745-20"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 36-323</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="subunit">
        <text evidence="5">Homomultimer; disulfide-linked. The virus capsid is composed of 72 icosahedral units, each one composed of five disulfide-linked copies of VP1. Interacts with minor capsid proteins VP2 and VP3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the polyomaviruses coat protein VP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="KF954417">
        <property type="protein sequence ID" value="AHZ11645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009030020.1">
        <property type="nucleotide sequence ID" value="NC_024118.1"/>
    </dbReference>
    <dbReference type="PDB" id="6Y5X">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J=36-323"/>
    </dbReference>
    <dbReference type="PDB" id="6Y5Y">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J=36-323"/>
    </dbReference>
    <dbReference type="SMR" id="A0A024B5J2"/>
    <dbReference type="GeneID" id="19394658"/>
    <dbReference type="KEGG" id="vg:19394658"/>
    <dbReference type="Proteomes" id="UP000145802">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.175.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000662">
        <property type="entry name" value="Capsid_VP1_Polyomavir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011222">
        <property type="entry name" value="dsDNA_vir_gr_I_capsid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036931">
        <property type="entry name" value="Polyomavir_VP1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00718">
        <property type="entry name" value="Polyoma_coat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88648">
        <property type="entry name" value="SSF88648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="8" id="KW-0426">Late protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="433"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain" evidence="12 13">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AHZ11645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000145802"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="6Y5X"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="6Y5Y"/>
        </source>
    </evidence>
    <sequence length="489" mass="53787" checksum="8B1F8E9FD931991C" modified="2014-07-09" version="1">MAPPRKRPRCAPPSKVTCVPKKCPIPTPVPKLLVKGGVEVLNIITGPDATTEIELWLEPRMGVNAPTGDRKEWYGYSEVIHHADGYDNNLLSVQMPQYSCARVQLPMLNTDMTCETLMMWEAVSCKTEVVGIGSLISVHLLEAKMEAGPNSDGPSRPIEGMNYHMFAVGGEPLDLQGIESNGQTKYATAIPAKSIHPNDIAKLPEEDKAQLQGLVPKAKAKLDKDGFYPVEEWSPDPSRNENSRYYGSFVGGLQTPPNLQFTNAVSTVLLDENGVGPLCKGDGLFVSCADICGVLVKADNEAIRYRGLPRYFKVTLRKRAVKNPYPITSLLGSLFTGLMPKMDGQPMSGPDAQVEEVRIYQGKEGLPADPDMKRYIDQFGQEQTPTPTPAAPAAVAALMEKWKEMYSEEHKFDQIHKWGFSYPGYLFTEKESAKQKPREVQMPQKTQTQGTEVLTEQNLITEEYTTSASPPPSLGGTTDLQKLPGTESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-07-09" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>A0A024B605</accession>
    <name>A0A024B605_9POLY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Minor capsid protein VP2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Minor structural protein VP2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">VP3</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">New Jersey polyomavirus-2013</name>
        <dbReference type="NCBI Taxonomy" id="1497391"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Sepolyvirales</taxon>
            <taxon>Polyomaviridae</taxon>
            <taxon>Alphapolyomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2014" name="J. Infect. Dis." volume="210" first="1595" last="1599">
            <title>Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy.</title>
            <authorList>
                <person name="Mishra N."/>
                <person name="Pereira M."/>
                <person name="Rhodes R.H."/>
                <person name="An P."/>
                <person name="Pipas J.M."/>
                <person name="Jain K."/>
                <person name="Kapoor A."/>
                <person name="Briese T."/>
                <person name="Faust P.L."/>
                <person name="Lipkin W.I."/>
            </authorList>
            <dbReference type="PubMed" id="24795478"/>
            <dbReference type="DOI" id="10.1093/infdis/jiu250"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">NJ-PyV-2013</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Host endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the polyomaviruses capsid protein VP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="KF954417">
        <property type="protein sequence ID" value="AHZ11644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009030019.1">
        <property type="nucleotide sequence ID" value="NC_024118.1"/>
    </dbReference>
    <dbReference type="GeneID" id="19394657"/>
    <dbReference type="KEGG" id="vg:19394657"/>
    <dbReference type="Proteomes" id="UP000145802">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044167">
        <property type="term" value="C:host cell endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001070">
        <property type="entry name" value="Polyoma_coat_VP2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00761">
        <property type="entry name" value="Polyoma_coat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1038">Host endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-1043">Host membrane</keyword>
    <keyword evidence="8" id="KW-0426">Late protein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1160">Virus entry into host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AHZ11644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000145802"/>
        </source>
    </evidence>
    <sequence length="187" mass="20462" checksum="0F1D1D55B3817105" modified="2014-07-09" version="1">MTVEGLSGIEALAQLGWTAEQFSNMAFISTTFSNAIGYGVLFQTVSGISSLISAGIRLGTSVSSVNRHQTEQELETIFGKIAHLIHVNLAFHLNPFNWCESIGGTVPTEFNFLSLDQLSKLGVVIENGRWVIQTTPSFDPMFESGILIERYEPPGGAYQRATPDWMLPLILRLNGASQEKTPVCPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2014-07-09" modified="2022-08-03" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>A0A024B6C0</accession>
    <name>A0A024B6C0_9POLY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Large T antigen</fullName>
        </recommendedName>
    </protein>
    <organism evidence="30 31">
        <name type="scientific">New Jersey polyomavirus-2013</name>
        <dbReference type="NCBI Taxonomy" id="1497391"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Sepolyvirales</taxon>
            <taxon>Polyomaviridae</taxon>
            <taxon>Alphapolyomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="30 31" key="1">
        <citation type="journal article" date="2014" name="J. Infect. Dis." volume="210" first="1595" last="1599">
            <title>Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy.</title>
            <authorList>
                <person name="Mishra N."/>
                <person name="Pereira M."/>
                <person name="Rhodes R.H."/>
                <person name="An P."/>
                <person name="Pipas J.M."/>
                <person name="Jain K."/>
                <person name="Kapoor A."/>
                <person name="Briese T."/>
                <person name="Faust P.L."/>
                <person name="Lipkin W.I."/>
            </authorList>
            <dbReference type="PubMed" id="24795478"/>
            <dbReference type="DOI" id="10.1093/infdis/jiu250"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">NJ-PyV-2013</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="22">Forms homohexamers in the presence of ATP. Interacts with host HDAC1. Interacts (via LXCXE domain) with host RB1; the interaction induces the aberrant dissociation of RB1-E2F1 complex thereby disrupting RB1's activity. Interacts (via LXCXE domain) with host pRB-related proteins RBL1 and RBL2. Interacts (via C-terminus) with host TOP1 and POLA1 allowing DNA replication. Interacts with host preinitiation complex components TBP, TFIIA and TFIID to regulate transcription initiation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="KF954417">
        <property type="protein sequence ID" value="AHZ11646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009030021.1">
        <property type="nucleotide sequence ID" value="NC_024118.1"/>
    </dbReference>
    <dbReference type="GeneID" id="19394659"/>
    <dbReference type="KEGG" id="vg:19394659"/>
    <dbReference type="Proteomes" id="UP000145802">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039645">
        <property type="term" value="P:modulation by virus of host G1/S transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039576">
        <property type="term" value="P:suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039502">
        <property type="term" value="P:suppression by virus of host type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016392">
        <property type="entry name" value="Lg_T_Ag_polyomavir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010932">
        <property type="entry name" value="Lg_T_Ag_Polyomavir_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003133">
        <property type="entry name" value="T_Ag_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017910">
        <property type="entry name" value="Znf_lg_T-Ag_D1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037102">
        <property type="entry name" value="Znf_lg_T-Ag_D1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06431">
        <property type="entry name" value="Polyoma_lg_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02217">
        <property type="entry name" value="T_Ag_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003368">
        <property type="entry name" value="Large_T_antigen_polyomaV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51287">
        <property type="entry name" value="T_AG_OBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51341">
        <property type="entry name" value="ZF_LTAG_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="17" id="KW-0007">Acetylation</keyword>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18 23" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0244">Early protein</keyword>
    <keyword evidence="20" id="KW-1078">G1/S host cell cycle checkpoint dysregulation by virus</keyword>
    <keyword evidence="7" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="8" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1090">Inhibition of host innate immune response by virus</keyword>
    <keyword evidence="14" id="KW-1114">Inhibition of host interferon signaling pathway by virus</keyword>
    <keyword evidence="21" id="KW-1096">Inhibition of host JAK1 by virus</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1121">Modulation of host cell cycle by virus</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="31" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0899">Viral immunoevasion</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="12 24" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="26">
        <location>
            <begin position="12"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="T-ag OBD" evidence="28">
        <location>
            <begin position="221"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="T-ag D1-type" evidence="29">
        <location>
            <begin position="347"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="SF3 helicase" evidence="27">
        <location>
            <begin position="476"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="T-ag OBD" evidence="23">
        <location>
            <begin position="221"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="102"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00026077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="AHZ11646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="Proteomes" id="UP000145802"/>
        </source>
    </evidence>
    <sequence length="711" mass="80282" checksum="C9CB13AFBC7BE641" modified="2014-07-09" version="1"> </sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>