<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-01-19" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1B2RWA4</accession>
    <name>A0A1B2RWA4_9PAPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major capsid protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">L1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Sparus aurata papillomavirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1885928"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Zurhausenvirales</taxon>
            <taxon>Papillomaviridae</taxon>
            <taxon>Secondpapillomavirinae</taxon>
            <taxon>Alefpapillomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2016" name="J. Virol." volume="90" first="8768" last="8779">
            <title>Concurrence of Iridovirus, Polyomavirus, and a Unique Member of a New Group of Fish Papillomaviruses in Lymphocystis Disease-Affected Gilthead Sea Bream.</title>
            <authorList>
                <person name="Lopez-Bueno A."/>
                <person name="Mavian C."/>
                <person name="Labella A.M."/>
                <person name="Castro D."/>
                <person name="Borrego J.J."/>
                <person name="Alcami A."/>
                <person name="Alejo A."/>
            </authorList>
            <dbReference type="PubMed" id="27440877"/>
            <dbReference type="DOI" id="10.1128/JVI.01369-16"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">SA9pv</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the papillomaviridae L1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KX643372">
        <property type="protein sequence ID" value="AOC55279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009272705.1">
        <property type="nucleotide sequence ID" value="NC_030839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28619807"/>
    <dbReference type="KEGG" id="vg:28619807"/>
    <dbReference type="Proteomes" id="UP000131472">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039620">
        <property type="term" value="C:T=7 icosahedral viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019062">
        <property type="term" value="P:virion attachment to host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.175.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002210">
        <property type="entry name" value="Capsid_L1_Papillomavir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036973">
        <property type="entry name" value="Capsid_L1_sf_Papillomavir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011222">
        <property type="entry name" value="dsDNA_vir_gr_I_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00500">
        <property type="entry name" value="Late_protein_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88648">
        <property type="entry name" value="SSF88648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="1 4" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3 4" id="KW-0426">Late protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1145">T=7 icosahedral capsid protein</keyword>
    <keyword evidence="4" id="KW-1161">Viral attachment to host cell</keyword>
    <keyword evidence="2 4" id="KW-0946">Virion</keyword>
    <keyword evidence="4" id="KW-1160">Virus entry into host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AOC55279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000131472"/>
        </source>
    </evidence>
    <sequence length="185" mass="20584" checksum="76C3D8206921EE51" modified="2016-11-02" version="1">MYQFLLSLIRKVNLFMYIEKEGVLRGEENVVLSIPYNCFTVYTSGRVPVALEYTEGGVPTEPYIKSTDEFVHETPITYIVKSDPIRIQGHPYKYVPAKTVNSKTLPAVPFVNPSRINVCRVDVPDLNKLIIPPLPGNLSLQTTTNVWKLVGFRIDIQGVQCPAVTGLSQSTVQSTDSGLERGTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-11-02" modified="2022-01-19" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>A0A1B2RWD2</accession>
    <name>A0A1B2RWD2_9PAPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major capsid protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">L1</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Sparus aurata papillomavirus 1</name>
        <dbReference type="NCBI Taxonomy" id="1885928"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Papovaviricetes</taxon>
            <taxon>Zurhausenvirales</taxon>
            <taxon>Papillomaviridae</taxon>
            <taxon>Secondpapillomavirinae</taxon>
            <taxon>Alefpapillomavirus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2016" name="J. Virol." volume="90" first="8768" last="8779">
            <title>Concurrence of Iridovirus, Polyomavirus, and a Unique Member of a New Group of Fish Papillomaviruses in Lymphocystis Disease-Affected Gilthead Sea Bream.</title>
            <authorList>
                <person name="Lopez-Bueno A."/>
                <person name="Mavian C."/>
                <person name="Labella A.M."/>
                <person name="Castro D."/>
                <person name="Borrego J.J."/>
                <person name="Alcami A."/>
                <person name="Alejo A."/>
            </authorList>
            <dbReference type="PubMed" id="27440877"/>
            <dbReference type="DOI" id="10.1128/JVI.01369-16"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">SA9pv</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Self-assembles into homopentamers. The capsid has an icosahedral symmetry and consists of 72 capsomers, with each capsomer being a pentamer of L1. Interacts with the minor capsid protein L2; this interaction is necessary for viral genome encapsidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the papillomaviridae L1 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="KX643372">
        <property type="protein sequence ID" value="AOC55281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="YP_009272706.1">
        <property type="nucleotide sequence ID" value="NC_030839.1"/>
    </dbReference>
    <dbReference type="GeneID" id="28619806"/>
    <dbReference type="KEGG" id="vg:28619806"/>
    <dbReference type="Proteomes" id="UP000131472">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039620">
        <property type="term" value="C:T=7 icosahedral viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019062">
        <property type="term" value="P:virion attachment to host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.175.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002210">
        <property type="entry name" value="Capsid_L1_Papillomavir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036973">
        <property type="entry name" value="Capsid_L1_sf_Papillomavir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011222">
        <property type="entry name" value="dsDNA_vir_gr_I_capsid"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00500">
        <property type="entry name" value="Late_protein_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00865">
        <property type="entry name" value="HPVCAPSIDL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88648">
        <property type="entry name" value="SSF88648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="1 4" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3 4" id="KW-0426">Late protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1145">T=7 icosahedral capsid protein</keyword>
    <keyword evidence="4" id="KW-1161">Viral attachment to host cell</keyword>
    <keyword evidence="2 4" id="KW-0946">Virion</keyword>
    <keyword evidence="4" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AOC55281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000131472"/>
        </source>
    </evidence>
    <sequence length="383" mass="42862" checksum="2526255FA8F99814" modified="2016-11-02" version="1">MGPFISSSVTAGEERPEEGSSWSQDYHPAHDAELESTDVKNYVWGLEHAQRQIICVGCKPALGYYEQWNPDTNVFFRGTDPLQDGVIHEFGYGNHWAGDSVDETVVPLEMLAGSEAEEKEKNFTYCLDKIGMDNDNTGDSNFLIIERQAEGVRHTLSAGNNDAEFTAGTGAYKNVTMSADPLCAKTAGMVSNSTDIFNKSYWLNKAKGVNNGILWGNKLYITFVDNMRGFIYRRNETSTASGSSYDPTKIQYRLRHIKEYQVSVIVRKCTVKLEAKLITSLLQLNKEWLANLGFKFNSPTAESLLHQNGIFRTVSDIVKIPEEEINETGDDIKCVVIDCNGSAEMKNVHHSSHILARHYREAGNVEKEEPSRAIKRKAKASQQ</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>