<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2006-03-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>Q2KSJ1</accession>
    <name>Q2KSJ1_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Orf6/7 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">E4</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="2 4 5" key="1">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">GB</strain>
            <strain evidence="2">NHRC 1276</strain>
        </source>
    </reference>
    <reference evidence="3 6" key="2">
        <citation type="journal article" date="2017" name="J. Med. Virol." volume="89" first="1387" last="1394">
            <title>Adenovirus type 4 respiratory infections with a concurrent outbreak of coxsackievirus A21 among United States Army Basic Trainees, a retrospective viral etiology study using next-generation sequencing.</title>
            <authorList>
                <person name="Hang J."/>
                <person name="Vento T.J."/>
                <person name="Norby E.A."/>
                <person name="Jarman R.G."/>
                <person name="Keiser P.B."/>
                <person name="Kuschner R.A."/>
                <person name="Binn L.N."/>
            </authorList>
            <dbReference type="PubMed" id="28198541"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 6">T382/Ft Jackson South Carolina USA/2002</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY599836">
        <property type="protein sequence ID" value="AAW33277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KX384958">
        <property type="protein sequence ID" value="ANQ44554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000126446">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000320097">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAW33186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAW33277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ANQ44554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000126446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000320097"/>
        </source>
    </evidence>
    <sequence length="83" mass="9374" checksum="79EC746F585F60D1" modified="2006-03-07" version="1">MTVIQTPESHPQQLDCESALKDYPDAFLCITDPRLARSETVWNVESKTMSISNGIQMFKAVRGERLVYSVKWEGGGKITTRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-07" modified="2022-08-03" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>Q2KSR4</accession>
    <name>Q2KSR4_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="1">14.3 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">E4</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">GB</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="SMR" id="Q2KSR4"/>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAW33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <sequence length="129" mass="14350" checksum="95797D1B67485D45" modified="2006-03-07" version="1">MLERSAVTYCICIPTVLNVSLENFSFIQFLQETLPDYISSNFDDITGGSQYAYSNLVFAGANWGGLRLYCTVASPAIVPGGLLAKQFGDNMREYLQLELREELRAKGMSIDDAILNLLQVTQEQDILSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-07" modified="2022-08-03" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>Q2KST3</accession>
    <name>Q2KST3_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="5">33 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">L4</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenoviridae splicing factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019073">
        <property type="term" value="P:viral DNA genome packaging"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021304">
        <property type="entry name" value="Adeno_L4-33K/L4-22K"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11081">
        <property type="entry name" value="DUF2890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0231">Viral genome packaging</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAW33173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <sequence length="245" mass="27591" checksum="D9F3533190E2C9BB" modified="2006-03-07" version="1">MSHRRGSKKLKVQLSPPEDMKEDWDSQAEEEMEDWDSQAEEVDSLEEDSLEEEDEEAEEVEEATAAKQLSSAAETSKSPDSSTATISAPGRGAQRRPNSRWDETGRFPNPTTASKTGKKERQGYKSWPPTAVSKSRQPRQKNTAATTVTRKPAVRKSTTSAPGGGLRITANEPAQTRELRNRIFPTLYAIFQQSRGQEQELKVKNRSLRSLTRSCLYHKSEDQLQRTLEDAEALFNKYCALTLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-07" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>Q2KSU3</accession>
    <name>Q2KSU3_ADE03</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Packaging protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">L1-52/55 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Packaging protein 52K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">L1</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in viral genome packaging through its interaction with packaging proteins 1 and 2. After proteolyic cleavage by adenovirus protease, L1 52/55k protein is removed from the capsid during viral maturation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of the genome packaging complex composed of packaging proteins 1, 2 and 3; this complex specifically binds to the packaging sequence on the left end of viral genomic DNA and performs packaging of the viral genome. Interacts with hexon-linking protein IIIa; this interaction is required to promote correct genome packaging.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Host nucleus</location>
        </subcellularLocation>
        <text evidence="3">Nuclear protein present in empty capsids and assembly intermediates.</text>
    </comment>
    <comment type="induction">
        <text evidence="3">Expressed in the early phase and late phase of the viral replicative cycle.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Cleaved at different sites by the viral protease during virion maturation.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adenoviridae packaging protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019073">
        <property type="term" value="P:viral DNA genome packaging"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04058">
        <property type="entry name" value="ADV_PKG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037536">
        <property type="entry name" value="ADV_PKG3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004292">
        <property type="entry name" value="L1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03052">
        <property type="entry name" value="Adeno_52K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="3" id="KW-0426">Late protein</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0231">Viral genome packaging</keyword>
    <keyword evidence="1 3" id="KW-1188">Viral release from host cell</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by host" evidence="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAW33162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <sequence length="378" mass="42885" checksum="4C778118C15FE4D0" modified="2006-03-07" version="1">MRPQQQAPSQQQPQKALLAPATTAAAAVSGAGQPAYDLDLEEGEGLARLGAPSPERHPRVQLKKDSREAYVPQQNLFRDRSGEEPEEMRASRFNAGRELRHGLDRRRVLQDEDFEVDEVTGISPARAHVAAANLVSAYEQTVKEERNFQKSFNNHVRTLIAREEVTLGLMHLWDLMEAIAQNPTSKPLTAQLFLVVQHSRDNEAFREALLNITEPDGRWLYDLINILQSIIVQERSLGLAEKVAAINYSVLSLGKYYARKIYKTPYVPIDKEVKIDGFYMRMTLKVLTLSDDLGVYRNDRMHRAVSASRRRELSDRELMHSLQRALTGAGTDGENYFDMGADLQWQPSRRAMEAAGCELPYIEEVDEVEDEEGEYLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-07" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q2KSU5</accession>
    <name>Q2KSU5_ADE03</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Preterminal protein</fullName>
            <shortName evidence="1">pTP</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bellett protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Precursor terminal protein</fullName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">Intermediate terminal protein</fullName>
                <shortName evidence="1">iTP</shortName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Terminal protein</fullName>
                <shortName evidence="1">TP</shortName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="3" type="primary">E2B</name>
        <name evidence="1" type="synonym">PTP</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">GB</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protein covalently bound to the viral DNA that acts as a primer for viral genomic replication by DNA strand displacement. Assembles on the viral origin of replication in an initiation complex with viral polymerase, DBP, host NFIA and host POU2F1/OCT1. During initiation, the polymerase covalently couples the first dCTP with Ser-580 of pTP. The terminal protein stimulates the template activity over 20 fold compared to protein-free templates. Neo-synthesized viral genomes are linked to two preterminal proteins, one for each 5' end. These new genomes are encapsidated in the nucleus, and during capsid maturation by viral protease, preterminal protein is first cleaved into intermediary (iTP), then into mature TP. May play a role in host nuclear matrix localization of genomic DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer with the polymerase; this heterodimer binds to bp 9 to 18 of the genome. Interacts with host POU2F1; POU2F1 binds to the auxiliary sequences in the inverted terminal repeats and tethers the pTP-POL heterodimer to the origin DNA thereby participating in the assembly of the pre-initiation complex (POL-TP-DBP-NFIA-POU2F1).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Preterminal protein is used to replicate viral genome, upon genomic encapsidation it is processed first into iTP and finally into TP by adenovirus protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenoviridae terminal protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044204">
        <property type="term" value="C:host cell nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039687">
        <property type="term" value="P:viral DNA strand displacement replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04061">
        <property type="entry name" value="ADV_TERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003391">
        <property type="entry name" value="Adeno_preterminal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02459">
        <property type="entry name" value="Adeno_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1194">Viral DNA replication</keyword>
    <feature type="chain" id="PRO_5023463430" description="Preterminal protein" evidence="1">
        <location>
            <begin position="1"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023463431" description="Intermediate terminal protein" evidence="1">
        <location>
            <begin position="176"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023463432" description="Terminal protein" evidence="1">
        <location>
            <begin position="339"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="632"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by adenovirus protease" evidence="1">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by adenovirus protease" evidence="1">
        <location>
            <begin position="338"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="site" description="Priming of strand displacement replication by covalently linking the first nucleotide of the new DNA chain" evidence="1">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(5'-phospho-DNA)-serine" evidence="1">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAW33160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <sequence length="658" mass="75657" checksum="30BF2088EC0AF545" modified="2006-03-07" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2006-03-07" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>Q2KSV4</accession>
    <name>Q2KSV4_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="2">6 kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">E1A</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAW33149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <sequence length="62" mass="7316" checksum="1E969EB35AB1881D" modified="2006-03-07" version="1">MRHLRFLPQEVISSETGIEILEFVVNTLMVLCLMMSHLLLIQLPHLLKFRRPHLQTYASPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0F1</accession>
    <name>Q2Y0F1_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="2">13.9 kDa protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">E4 ORF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">E4</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="DIP" id="DIP-61719N"/>
    <dbReference type="IntAct" id="Q2Y0F1">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAW33192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB17792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="125" mass="14148" checksum="09F94AC76BEF6FEB" modified="2005-12-20" version="1">MADEALYVYLEGPGATLPEQQQRNNYIFYSPVPFTLYPRGVALLYLKLSIIIPRGYVGCFFSLTDANMSGLYASSRIIHAGHREELSVLLFNHNDRFYEGRAGDPVACLVMERLIFPPVRQATMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0F3</accession>
    <name>Q2Y0F3_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="1">11 kDa protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">E4 ORF3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">E4</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">GB</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009699">
        <property type="entry name" value="Mastadenovirus_E4/Orf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038368">
        <property type="entry name" value="Mastadenovirus_E4/Orf3_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06931">
        <property type="entry name" value="Adeno_E4_ORF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAW33190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB17794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="117" mass="13608" checksum="5D5549A3113D5940" modified="2005-12-20" version="1">MRVCLRMVVEGALRDLFVMCGLDLPQELTRIIQGWKAENYLGMVQECNMMFEELENAPSFGILLFLDVRVEALLEATVEHLENRISFDLAVLFHQHSGGDRCHLRDLQFEVLRDRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0F5</accession>
    <name>Q2Y0F5_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="1">13.6 kDa protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">E4 ORF4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">E4</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="2 4" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1 3" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">GB</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008680">
        <property type="entry name" value="M_adenovirusE4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05385">
        <property type="entry name" value="Adeno_E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAW33188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB17795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="122" mass="14337" checksum="6D7CC8593A89CC99" modified="2005-12-20" version="1">MILPSLPSPLLLETQSSCIAWLGFAYATVDDFLRTIKYDGVLITTEASILLTNLRVWLYLNYQTEHTKRQDRRRRRVCCARAAFCYTKYENVRKQLHYDKVARTLHIMRQTSPLHQSPITTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0F9</accession>
    <name>Q2Y0F9_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="4">14 kDa protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="5">E3 15.3-kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">E3B</name>
        <name evidence="4" type="synonym">E3</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">GB</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenoviridae E3_15 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019049">
        <property type="term" value="P:mitigation of host antiviral defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039650">
        <property type="term" value="P:suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004985">
        <property type="entry name" value="Adeno_E3-15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03307">
        <property type="entry name" value="Adeno_E3_15_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0244">Early protein</keyword>
    <keyword evidence="3" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3" id="KW-1085">Inhibition of host caspases by virus</keyword>
    <keyword evidence="3" id="KW-1119">Modulation of host cell apoptosis by virus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAW33183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB17791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="136" mass="15266" checksum="DFD57C08897A82D8" modified="2005-12-20" version="1">MTDPIATSSTAAKELLDMDGRASEQRLIQLRIRQQQERAVKELRDAIGIHQCKKGIFCLVKQSKISYEITATDHRLSYELGPQRQKFTCMVGINPIVITQQSGDTKGCIQCSCDSTECIYTLLKTLCGLRDLLPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0G1</accession>
    <name>Q2Y0G1_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="7">10.3 kDa protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="9">E3 10.2-kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">E3B</name>
        <name evidence="7" type="synonym">E3</name>
    </gene>
    <organism evidence="9 43">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="9 43" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 42 44" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">GB</strain>
            <strain evidence="8">NHRC 1276</strain>
        </source>
    </reference>
    <reference evidence="10 45" key="3">
        <citation type="journal article" date="2017" name="J. Med. Virol." volume="89" first="1387" last="1394">
            <title>Adenovirus type 4 respiratory infections with a concurrent outbreak of coxsackievirus A21 among United States Army Basic Trainees, a retrospective viral etiology study using next-generation sequencing.</title>
            <authorList>
                <person name="Hang J."/>
                <person name="Vento T.J."/>
                <person name="Norby E.A."/>
                <person name="Jarman R.G."/>
                <person name="Keiser P.B."/>
                <person name="Kuschner R.A."/>
                <person name="Binn L.N."/>
            </authorList>
            <dbReference type="PubMed" id="28198541"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 45">T382/Ft Jackson South Carolina USA/2002</strain>
        </source>
    </reference>
    <reference evidence="11" key="4">
        <citation type="submission" date="2021-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Duan Y."/>
                <person name="Zhu Y."/>
                <person name="Chen X."/>
                <person name="Xie Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="11">BJ20160214</strain>
            <strain evidence="12">BJ20170281</strain>
            <strain evidence="13">BJ20170284</strain>
            <strain evidence="14">BJ20170320</strain>
            <strain evidence="15">BJ20170379</strain>
            <strain evidence="16">BJ20180075</strain>
            <strain evidence="17">BJ20180080</strain>
            <strain evidence="18">BJ20180274</strain>
            <strain evidence="19">BJ20180444</strain>
            <strain evidence="20">BJ20180567</strain>
            <strain evidence="21">BJ20180581</strain>
            <strain evidence="22">BJ20180612</strain>
            <strain evidence="23">BJ20180641</strain>
            <strain evidence="24">BJ20180681</strain>
            <strain evidence="25">BJ20180705</strain>
            <strain evidence="26">BJ20180708</strain>
            <strain evidence="27">BJ20180718</strain>
            <strain evidence="28">BJ20180730</strain>
            <strain evidence="29">BJ20180734</strain>
            <strain evidence="30">BJ20180775</strain>
            <strain evidence="31">CC20150103</strain>
            <strain evidence="32">GZ20150036</strain>
            <strain evidence="33">HB20140057</strain>
            <strain evidence="34">HB20150126</strain>
            <strain evidence="35">SH20160051</strain>
            <strain evidence="36">SH20160055</strain>
            <strain evidence="37">WZ20150066</strain>
            <strain evidence="38">WZ20150082</strain>
            <strain evidence="39">ZJ20150106</strain>
            <strain evidence="40">ZJ20150111</strain>
            <strain evidence="41">ZJ20150114</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY599836">
        <property type="protein sequence ID" value="AAW33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KX384958">
        <property type="protein sequence ID" value="ANQ44549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748641">
        <property type="protein sequence ID" value="QTW00077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748642">
        <property type="protein sequence ID" value="QTW00114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748643">
        <property type="protein sequence ID" value="QTW00151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748645">
        <property type="protein sequence ID" value="QTW00225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748646">
        <property type="protein sequence ID" value="QTW00262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748647">
        <property type="protein sequence ID" value="QTW00299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748648">
        <property type="protein sequence ID" value="QTW00336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748649">
        <property type="protein sequence ID" value="QTW00373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748650">
        <property type="protein sequence ID" value="QTW00410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748651">
        <property type="protein sequence ID" value="QTW00447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748652">
        <property type="protein sequence ID" value="QTW00484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748653">
        <property type="protein sequence ID" value="QTW00521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748654">
        <property type="protein sequence ID" value="QTW00558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748655">
        <property type="protein sequence ID" value="QTW00595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748656">
        <property type="protein sequence ID" value="QTW00632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748657">
        <property type="protein sequence ID" value="QTW00669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748658">
        <property type="protein sequence ID" value="QTW00706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748659">
        <property type="protein sequence ID" value="QTW00743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748660">
        <property type="protein sequence ID" value="QTW00780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748661">
        <property type="protein sequence ID" value="QTW00817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748662">
        <property type="protein sequence ID" value="QTW00854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748663">
        <property type="protein sequence ID" value="QTW00891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748664">
        <property type="protein sequence ID" value="QTW00928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748665">
        <property type="protein sequence ID" value="QTW00965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748666">
        <property type="protein sequence ID" value="QTW01002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748667">
        <property type="protein sequence ID" value="QTW01039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748668">
        <property type="protein sequence ID" value="QTW01076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748669">
        <property type="protein sequence ID" value="QTW01113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748670">
        <property type="protein sequence ID" value="QTW01150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748671">
        <property type="protein sequence ID" value="QTW01187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748672">
        <property type="protein sequence ID" value="QTW01224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000126446">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000320097">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000675949">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000676114">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000676124">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000676286">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677202">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677359">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677400">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677516">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678076">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678238">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678261">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678392">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678455">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678994">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000679053">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000679582">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680298">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680322">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680510">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680661">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680901">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680993">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681024">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681206">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681318">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681613">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681683">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000682026">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000682366">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000682781">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000683097">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005041">
        <property type="entry name" value="Adeno_E3B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03376">
        <property type="entry name" value="Adeno_E3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0244">Early protein</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="42" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAW33181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAW33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB17789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ANQ44549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QTW00077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QTW00114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QTW00151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QTW00225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QTW00262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QTW00299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QTW00336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QTW00373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QTW00410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QTW00447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QTW00484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QTW00521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="QTW00558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="QTW00595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="QTW00632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="QTW00669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="QTW00706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="QTW00743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="QTW00780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="QTW00817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="QTW00854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="QTW00891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="QTW00928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="QTW00965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="QTW01002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="QTW01039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EMBL" id="QTW01076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="EMBL" id="QTW01113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="EMBL" id="QTW01150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="EMBL" id="QTW01187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="EMBL" id="QTW01224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="Proteomes" id="UP000126446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Proteomes" id="UP000320097"/>
        </source>
    </evidence>
    <sequence length="91" mass="10330" checksum="0C85346008CE2C54" modified="2005-12-20" version="1">MIPRNFFFTILICAFNVCATFTAVATASPDCIGPFASYALFAFVTCICVCSIVCLVINFFQLVDWIFVRIAYLRHHPEYRNQNVAALLRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="30" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0G2</accession>
    <name>Q2Y0G2_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="2">9 kDa glycoprotein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">E3 9-kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">E3B</name>
        <name evidence="2" type="synonym">E3</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAW33180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB17788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="77" mass="9014" checksum="3B77061A20AE68B1" modified="2005-12-20" version="1">MILFQSNTTTSYAYTNIQPKYAMQLEITILIVIGILILSVILYFIFCRQIPNVHRNSKRRPIYSPMISRPHMALNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0G4</accession>
    <name>Q2Y0G4_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="5">20.1 kDa protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">E3 20.1-kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">E3B</name>
        <name evidence="5" type="synonym">E3</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenoviridae E3_20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003471">
        <property type="entry name" value="Adeno_E3_CR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003470">
        <property type="entry name" value="Adeno_E3_CR2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02440">
        <property type="entry name" value="Adeno_E3_CR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02439">
        <property type="entry name" value="Adeno_E3_CR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Adeno_E3_CR1" evidence="4">
        <location>
            <begin position="14"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Adeno_E3_CR2" evidence="3">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAW33178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB17786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="179" mass="20059" checksum="A5E214BB78B14D51" modified="2005-12-20" version="1">MASVTALIIASIVTVAHGQTIVHITLGHNHTLVGPPITSEVIWTKLGSVDYFDIICNKTKPIFVICNRQNLTLINVSKIYNGYYYGYDRSSSQYKNYLVRITQPKLTVPTMTIIKMANKALENFTSPTTPNEKNIPNSMIAIIAAVALGMALIIICMLLYACYYKKFQHKQDPLLNFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0G6</accession>
    <name>Q2Y0G6_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="2">16 kDa protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">E3 16-kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">E3A</name>
        <name evidence="2" type="synonym">E3</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="3 5" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 4" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009266">
        <property type="entry name" value="Adeno_E3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06040">
        <property type="entry name" value="Adeno_E3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAW33176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB17784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="146" mass="16047" checksum="67FE8379B90C6338" modified="2005-12-20" version="1">MKAFAVLFVLSLIKTELRPSYGLPLLQSGLYNTNQIFQKTQTLPPFIQDSNSTLPAPSTTNLPETNKLASHLQHRLSRSLLSANTTTPKTGGELRGLPTDDPWVVAGFVTLGVVAGGLVLILCYLYTPCCAYLVILCCWFKKWGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0G7</accession>
    <name>Q2Y0G7_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="4">12.1 kDa protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="3">12.2 kDa glycoprotein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="1">12.5 kDa glycoprotein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="2">E3 12.1-kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">E3A</name>
        <name evidence="1" type="synonym">E3</name>
    </gene>
    <organism evidence="2 36">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="2 36" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="1 35" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">GB</strain>
        </source>
    </reference>
    <reference evidence="3 37" key="3">
        <citation type="journal article" date="2017" name="J. Med. Virol." volume="89" first="1387" last="1394">
            <title>Adenovirus type 4 respiratory infections with a concurrent outbreak of coxsackievirus A21 among United States Army Basic Trainees, a retrospective viral etiology study using next-generation sequencing.</title>
            <authorList>
                <person name="Hang J."/>
                <person name="Vento T.J."/>
                <person name="Norby E.A."/>
                <person name="Jarman R.G."/>
                <person name="Keiser P.B."/>
                <person name="Kuschner R.A."/>
                <person name="Binn L.N."/>
            </authorList>
            <dbReference type="PubMed" id="28198541"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 37">T382/Ft Jackson South Carolina USA/2002</strain>
        </source>
    </reference>
    <reference evidence="4" key="4">
        <citation type="submission" date="2021-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Duan Y."/>
                <person name="Zhu Y."/>
                <person name="Chen X."/>
                <person name="Xie Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">BJ20160214</strain>
            <strain evidence="5">BJ20170281</strain>
            <strain evidence="6">BJ20170284</strain>
            <strain evidence="7">BJ20170287</strain>
            <strain evidence="8">BJ20170320</strain>
            <strain evidence="9">BJ20170379</strain>
            <strain evidence="10">BJ20180075</strain>
            <strain evidence="11">BJ20180080</strain>
            <strain evidence="12">BJ20180274</strain>
            <strain evidence="13">BJ20180444</strain>
            <strain evidence="14">BJ20180567</strain>
            <strain evidence="15">BJ20180581</strain>
            <strain evidence="16">BJ20180612</strain>
            <strain evidence="17">BJ20180641</strain>
            <strain evidence="18">BJ20180681</strain>
            <strain evidence="19">BJ20180705</strain>
            <strain evidence="20">BJ20180718</strain>
            <strain evidence="21">BJ20180730</strain>
            <strain evidence="22">BJ20180734</strain>
            <strain evidence="23">BJ20180775</strain>
            <strain evidence="24">CC20150103</strain>
            <strain evidence="25">GZ20150036</strain>
            <strain evidence="26">HB20140057</strain>
            <strain evidence="27">HB20150126</strain>
            <strain evidence="28">SH20160051</strain>
            <strain evidence="29">SH20160055</strain>
            <strain evidence="30">WZ20150066</strain>
            <strain evidence="31">WZ20150082</strain>
            <strain evidence="32">ZJ20150106</strain>
            <strain evidence="33">ZJ20150111</strain>
            <strain evidence="34">ZJ20150114</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KX384958">
        <property type="protein sequence ID" value="ANQ44545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748641">
        <property type="protein sequence ID" value="QTW00072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748642">
        <property type="protein sequence ID" value="QTW00109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748643">
        <property type="protein sequence ID" value="QTW00146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748644">
        <property type="protein sequence ID" value="QTW00183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748645">
        <property type="protein sequence ID" value="QTW00220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748646">
        <property type="protein sequence ID" value="QTW00257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748647">
        <property type="protein sequence ID" value="QTW00294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748648">
        <property type="protein sequence ID" value="QTW00331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748649">
        <property type="protein sequence ID" value="QTW00368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748650">
        <property type="protein sequence ID" value="QTW00405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748651">
        <property type="protein sequence ID" value="QTW00442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748652">
        <property type="protein sequence ID" value="QTW00479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748653">
        <property type="protein sequence ID" value="QTW00516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748654">
        <property type="protein sequence ID" value="QTW00553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748655">
        <property type="protein sequence ID" value="QTW00590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748656">
        <property type="protein sequence ID" value="QTW00627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748658">
        <property type="protein sequence ID" value="QTW00701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748659">
        <property type="protein sequence ID" value="QTW00738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748660">
        <property type="protein sequence ID" value="QTW00775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748661">
        <property type="protein sequence ID" value="QTW00812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748662">
        <property type="protein sequence ID" value="QTW00849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748663">
        <property type="protein sequence ID" value="QTW00886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748664">
        <property type="protein sequence ID" value="QTW00923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748665">
        <property type="protein sequence ID" value="QTW00960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748666">
        <property type="protein sequence ID" value="QTW00997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748667">
        <property type="protein sequence ID" value="QTW01034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748668">
        <property type="protein sequence ID" value="QTW01071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748669">
        <property type="protein sequence ID" value="QTW01108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748670">
        <property type="protein sequence ID" value="QTW01145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748671">
        <property type="protein sequence ID" value="QTW01182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748672">
        <property type="protein sequence ID" value="QTW01219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000320097">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000676114">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000676124">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000676286">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677202">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677359">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677400">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677516">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678076">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678238">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678261">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678392">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678455">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678994">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000679053">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000679582">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680298">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680322">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680510">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680661">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680901">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680993">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681024">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681206">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681318">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681613">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681683">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000682026">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000682324">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000682366">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000682781">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000683097">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007912">
        <property type="entry name" value="Adeno_E3A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05248">
        <property type="entry name" value="Adeno_E3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAW33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB17783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ANQ44545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="QTW00072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="QTW00109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QTW00146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QTW00183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QTW00220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QTW00257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QTW00294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QTW00331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QTW00368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QTW00405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QTW00442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QTW00479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QTW00516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QTW00553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QTW00590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QTW00627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QTW00701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QTW00738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QTW00775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="QTW00812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="QTW00849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="QTW00886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="QTW00923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="QTW00960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="QTW00997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="QTW01034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="QTW01071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="QTW01108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="QTW01145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="QTW01182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="QTW01219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000320097"/>
        </source>
    </evidence>
    <sequence length="106" mass="12124" checksum="C0374ACAB6CEEEC0" modified="2005-12-20" version="1">MSNGGAAELARLRHLDHCRRFRCFARELTEFIYFELSEEHPQGPAHGVRITIEGGIDSRLHRIFSQRPVLIERDQGNTTISIYCICNHPGLHESLCCLVCAEFNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0G8</accession>
    <name>Q2Y0G8_ADE03</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pre-hexon-linking protein VIII</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pre-protein VIII</fullName>
            <shortName evidence="1">pVIII</shortName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">Hexon-linking protein-N</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">12.1 kDa protein VIII</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Protein VIII-N</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Hexon-linking protein-C</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">7.6 kDa protein VIII</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Protein VIII-C</fullName>
            </alternativeName>
        </component>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">L4</name>
    </gene>
    <organism evidence="4 37">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="4 37" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="2 36 38" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">GB</strain>
            <strain evidence="3">NHRC 1276</strain>
        </source>
    </reference>
    <reference evidence="5 39" key="3">
        <citation type="journal article" date="2017" name="J. Med. Virol." volume="89" first="1387" last="1394">
            <title>Adenovirus type 4 respiratory infections with a concurrent outbreak of coxsackievirus A21 among United States Army Basic Trainees, a retrospective viral etiology study using next-generation sequencing.</title>
            <authorList>
                <person name="Hang J."/>
                <person name="Vento T.J."/>
                <person name="Norby E.A."/>
                <person name="Jarman R.G."/>
                <person name="Keiser P.B."/>
                <person name="Kuschner R.A."/>
                <person name="Binn L.N."/>
            </authorList>
            <dbReference type="PubMed" id="28198541"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 39">T382/Ft Jackson South Carolina USA/2002</strain>
        </source>
    </reference>
    <reference evidence="6" key="4">
        <citation type="submission" date="2021-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Duan Y."/>
                <person name="Zhu Y."/>
                <person name="Chen X."/>
                <person name="Xie Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">BJ20160214</strain>
            <strain evidence="7">BJ20170281</strain>
            <strain evidence="8">BJ20170284</strain>
            <strain evidence="9">BJ20170320</strain>
            <strain evidence="10">BJ20170379</strain>
            <strain evidence="11">BJ20180075</strain>
            <strain evidence="12">BJ20180080</strain>
            <strain evidence="13">BJ20180274</strain>
            <strain evidence="14">BJ20180444</strain>
            <strain evidence="15">BJ20180567</strain>
            <strain evidence="16">BJ20180581</strain>
            <strain evidence="17">BJ20180612</strain>
            <strain evidence="18">BJ20180641</strain>
            <strain evidence="19">BJ20180681</strain>
            <strain evidence="20">BJ20180705</strain>
            <strain evidence="21">BJ20180708</strain>
            <strain evidence="22">BJ20180718</strain>
            <strain evidence="23">BJ20180730</strain>
            <strain evidence="24">BJ20180734</strain>
            <strain evidence="25">BJ20180775</strain>
            <strain evidence="26">CC20150103</strain>
            <strain evidence="27">GZ20150036</strain>
            <strain evidence="28">HB20140057</strain>
            <strain evidence="29">HB20150126</strain>
            <strain evidence="30">SH20160051</strain>
            <strain evidence="31">SH20160055</strain>
            <strain evidence="32">WZ20150066</strain>
            <strain evidence="33">WZ20150082</strain>
            <strain evidence="34">ZJ20150106</strain>
            <strain evidence="35">ZJ20150114</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Hexon-linking protein-C: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Hexon-linking protein-N: Structural component of the virion that acts as a cement protein on the capsid interior and which glue the peripentonal hexons and group-of-nine hexons together.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the peripentonal hexons as well as the hexons in the facets. Part of a complex composed of the core-capsid bridging protein, the endosome lysis protein VI and the hexon-linking protein VIII; these interactions bridge the virus core to the capsid.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Hexon-linking protein-N</molecule>
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <text evidence="1">Located on the inner side of the capsid shell. Present in 120 copies per virion.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Hexon-linking protein-C</molecule>
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
        <text evidence="1">Located on the inner side of the capsid shell. Present in 120 copies per virion.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Pre-hexon-linking protein VIII</molecule>
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">Expressed in the late phase of the viral replicative cycle.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Cleaved by the viral protease during virion maturation. May cause the middle segment to be shed from the capsid.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenoviridae hexon-linking protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY599836">
        <property type="protein sequence ID" value="AAW33266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KX384958">
        <property type="protein sequence ID" value="ANQ44544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748641">
        <property type="protein sequence ID" value="QTW00071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748642">
        <property type="protein sequence ID" value="QTW00108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748643">
        <property type="protein sequence ID" value="QTW00145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748645">
        <property type="protein sequence ID" value="QTW00219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748646">
        <property type="protein sequence ID" value="QTW00256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748647">
        <property type="protein sequence ID" value="QTW00293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748648">
        <property type="protein sequence ID" value="QTW00330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748649">
        <property type="protein sequence ID" value="QTW00367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748650">
        <property type="protein sequence ID" value="QTW00404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748651">
        <property type="protein sequence ID" value="QTW00441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748652">
        <property type="protein sequence ID" value="QTW00478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748653">
        <property type="protein sequence ID" value="QTW00515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748654">
        <property type="protein sequence ID" value="QTW00552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748655">
        <property type="protein sequence ID" value="QTW00589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748656">
        <property type="protein sequence ID" value="QTW00626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748657">
        <property type="protein sequence ID" value="QTW00663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748658">
        <property type="protein sequence ID" value="QTW00700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748659">
        <property type="protein sequence ID" value="QTW00737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748660">
        <property type="protein sequence ID" value="QTW00774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748661">
        <property type="protein sequence ID" value="QTW00811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748662">
        <property type="protein sequence ID" value="QTW00848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748663">
        <property type="protein sequence ID" value="QTW00885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748664">
        <property type="protein sequence ID" value="QTW00922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748665">
        <property type="protein sequence ID" value="QTW00959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748666">
        <property type="protein sequence ID" value="QTW00996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748667">
        <property type="protein sequence ID" value="QTW01033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748668">
        <property type="protein sequence ID" value="QTW01070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748669">
        <property type="protein sequence ID" value="QTW01107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748670">
        <property type="protein sequence ID" value="QTW01144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748672">
        <property type="protein sequence ID" value="QTW01218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000126446">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000320097">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000675949">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000676114">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000676124">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000676286">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677202">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677359">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677400">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677516">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678076">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678238">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678261">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678392">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678994">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000679053">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000679582">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680298">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680322">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680510">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680661">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680901">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680993">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681024">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681206">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681318">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681613">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681683">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000682026">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000682366">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000682781">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000683097">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031423">
        <property type="term" value="F:hexon binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04049">
        <property type="entry name" value="ADV_CAP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000646">
        <property type="entry name" value="Adeno_PVIII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01310">
        <property type="entry name" value="Adeno_PVIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="1" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="1" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="1" id="KW-0426">Late protein</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="36" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_5035345147" description="Pre-hexon-linking protein VIII" evidence="1">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_5035345148" description="Hexon-linking protein-N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_5035345145" evidence="1">
        <location>
            <begin position="112"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="peptide" id="PRO_5035345146" description="Hexon-linking protein-C" evidence="1">
        <location>
            <begin position="158"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by viral protease" evidence="1">
        <location>
            <begin position="111"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by viral protease" evidence="1">
        <location>
            <begin position="157"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by host" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by host" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine; by host" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAW33174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAW33266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB17808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ANQ44544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="QTW00071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="QTW00108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="QTW00145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="QTW00219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QTW00256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="QTW00293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="QTW00330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QTW00367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QTW00404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QTW00441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QTW00478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QTW00515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QTW00552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QTW00589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QTW00626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QTW00663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QTW00700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="QTW00737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="QTW00774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="QTW00811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="QTW00848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="QTW00885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="QTW00922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="QTW00959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="QTW00996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="QTW01033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="QTW01070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="QTW01107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="QTW01144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="QTW01218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="Proteomes" id="UP000126446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="Proteomes" id="UP000320097"/>
        </source>
    </evidence>
    <sequence length="227" mass="24916" checksum="72A70E8E833F4A59" modified="2005-12-20" version="1">MSKEIPTPYMWSYQPQMGLAAGASQDYSTRMNWLSAGPSMISRVNDIRAYRNQLLLEQSALTTTPRQHLNPRNWPATLVYQENPAPTTVLLPRDAQAEVQMTNAGVQLAGGSALCRHRPQQSIKRLVIRGRGIQLNDESVSSSLGLRPDGVFQIAGCGRSSFTPRQAVLTLESSSSQPRSGGIGTLQFVEEFTPSVYFNPFSGSPGQYPDEFIPNFDAISESVDGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0G9</accession>
    <name>Q2Y0G9_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="5">22 kDa protein</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="6">L4 22-kDa protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">L4</name>
    </gene>
    <organism evidence="6 8">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="6 8" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenoviridae splicing factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019073">
        <property type="term" value="P:viral DNA genome packaging"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021304">
        <property type="entry name" value="Adeno_L4-33K/L4-22K"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11081">
        <property type="entry name" value="DUF2890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0231">Viral genome packaging</keyword>
    <keyword evidence="2" id="KW-1188">Viral release from host cell</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAW33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB17806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="199" mass="22533" checksum="86FC29BB360EC294" modified="2005-12-20" version="1">MSHRRGSKKLKVQLSPPEDMKEDWDSQAEEEMEDWDSQAEEVDSLEEDSLEEEDEEAEEVEEATAAKQLSSAAETSKSPDSSTATISAPGRGAQRRPNSRWDETGRFPNPTTASKTGKKERQGYKSWRGHKNAIISCLHECGGNISFTRRYLLFHHGVNFPRNILHYYRHLHSPYCSQQVPATPTEKYSSDNGDQKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0H3</accession>
    <name>Q2Y0H3_ADE03</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protease</fullName>
            <ecNumber evidence="6">3.4.22.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Adenain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenovirus protease</fullName>
            <shortName evidence="6">AVP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenovirus proteinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Endoprotease</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">L3</name>
    </gene>
    <organism evidence="11 43">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="11 43" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="9 42 44" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">GB</strain>
            <strain evidence="10">NHRC 1276</strain>
        </source>
    </reference>
    <reference evidence="12 45" key="3">
        <citation type="journal article" date="2017" name="J. Med. Virol." volume="89" first="1387" last="1394">
            <title>Adenovirus type 4 respiratory infections with a concurrent outbreak of coxsackievirus A21 among United States Army Basic Trainees, a retrospective viral etiology study using next-generation sequencing.</title>
            <authorList>
                <person name="Hang J."/>
                <person name="Vento T.J."/>
                <person name="Norby E.A."/>
                <person name="Jarman R.G."/>
                <person name="Keiser P.B."/>
                <person name="Kuschner R.A."/>
                <person name="Binn L.N."/>
            </authorList>
            <dbReference type="PubMed" id="28198541"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 45">T382/Ft Jackson South Carolina USA/2002</strain>
        </source>
    </reference>
    <reference evidence="13" key="4">
        <citation type="submission" date="2021-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Duan Y."/>
                <person name="Zhu Y."/>
                <person name="Chen X."/>
                <person name="Xie Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="13">BJ20170281</strain>
            <strain evidence="14">BJ20170284</strain>
            <strain evidence="15">BJ20170287</strain>
            <strain evidence="16">BJ20170320</strain>
            <strain evidence="17">BJ20170379</strain>
            <strain evidence="18">BJ20180075</strain>
            <strain evidence="19">BJ20180080</strain>
            <strain evidence="20">BJ20180274</strain>
            <strain evidence="21">BJ20180444</strain>
            <strain evidence="22">BJ20180567</strain>
            <strain evidence="23">BJ20180581</strain>
            <strain evidence="24">BJ20180612</strain>
            <strain evidence="25">BJ20180641</strain>
            <strain evidence="26">BJ20180681</strain>
            <strain evidence="27">BJ20180705</strain>
            <strain evidence="28">BJ20180708</strain>
            <strain evidence="29">BJ20180718</strain>
            <strain evidence="30">BJ20180730</strain>
            <strain evidence="31">BJ20180734</strain>
            <strain evidence="32">BJ20180775</strain>
            <strain evidence="33">CC20150103</strain>
            <strain evidence="34">GZ20150036</strain>
            <strain evidence="35">HB20140057</strain>
            <strain evidence="36">SH20160051</strain>
            <strain evidence="37">SH20160055</strain>
            <strain evidence="38">WZ20150082</strain>
            <strain evidence="39">ZJ20150106</strain>
            <strain evidence="40">ZJ20150111</strain>
            <strain evidence="41">ZJ20150114</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cleaves viral precursor proteins (pTP, pIIIa, pVI, pVII, pVIII, and pX) inside newly assembled particles giving rise to mature virions. Protease complexed to its cofactor slides along the viral DNA to specifically locate and cleave the viral precursors. Mature virions have a weakened organization compared to the unmature virions, thereby facilitating subsequent uncoating. Without maturation, the particle lacks infectivity and is unable to uncoat. Late in adenovirus infection, in the cytoplasm, may participate in the cytoskeleton destruction. Cleaves host cell cytoskeletal keratins K7 and K18.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>Cleaves proteins of the adenovirus and its host cell at two consensus sites: -Yaa-Xaa-Gly-Gly-|-Xaa- and -Yaa-Xaa-Gly-Xaa-|-Gly- (in which Yaa is Met, Ile or Leu, and Xaa is any amino acid).</text>
            <dbReference type="EC" id="3.4.22.39"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="6">Requires DNA and protease cofactor for maximal activation. Inside nascent virions, becomes partially activated by binding to the viral DNA, allowing it to cleave the cofactor that binds to the protease and fully activates it. Actin, like the viral protease cofactor, seems to act as a cofactor in the cleavage of cytokeratin 18 and of actin itself.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with protease cofactor pVI-C; this interaction is necessary for protease activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Virion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Host nucleus</location>
        </subcellularLocation>
        <text evidence="6">Present in about 10 copies per virion.</text>
    </comment>
    <comment type="induction">
        <text evidence="6">Expressed in the late phase of the viral replicative cycle.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="6">All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase C5 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.39" evidence="6"/>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY599836">
        <property type="protein sequence ID" value="AAW33261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="KX384958">
        <property type="protein sequence ID" value="ANQ44539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748642">
        <property type="protein sequence ID" value="QTW00103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748643">
        <property type="protein sequence ID" value="QTW00140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748644">
        <property type="protein sequence ID" value="QTW00177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748645">
        <property type="protein sequence ID" value="QTW00214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748646">
        <property type="protein sequence ID" value="QTW00251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748647">
        <property type="protein sequence ID" value="QTW00288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748648">
        <property type="protein sequence ID" value="QTW00325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748649">
        <property type="protein sequence ID" value="QTW00362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748650">
        <property type="protein sequence ID" value="QTW00399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748651">
        <property type="protein sequence ID" value="QTW00436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748652">
        <property type="protein sequence ID" value="QTW00473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748653">
        <property type="protein sequence ID" value="QTW00510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748654">
        <property type="protein sequence ID" value="QTW00547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748655">
        <property type="protein sequence ID" value="QTW00584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748656">
        <property type="protein sequence ID" value="QTW00621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748657">
        <property type="protein sequence ID" value="QTW00658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748658">
        <property type="protein sequence ID" value="QTW00695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748659">
        <property type="protein sequence ID" value="QTW00732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748660">
        <property type="protein sequence ID" value="QTW00769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748661">
        <property type="protein sequence ID" value="QTW00806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748662">
        <property type="protein sequence ID" value="QTW00843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748663">
        <property type="protein sequence ID" value="QTW00880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748664">
        <property type="protein sequence ID" value="QTW00917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748666">
        <property type="protein sequence ID" value="QTW00991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748667">
        <property type="protein sequence ID" value="QTW01028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748669">
        <property type="protein sequence ID" value="QTW01102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748670">
        <property type="protein sequence ID" value="QTW01139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748671">
        <property type="protein sequence ID" value="QTW01176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748672">
        <property type="protein sequence ID" value="QTW01213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="MEROPS" id="C05.001"/>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000126446">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000320097">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000675949">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000676114">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000676124">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000676286">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677202">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677359">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677400">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000677516">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678076">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678238">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678261">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678392">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678455">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000679053">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000679582">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680298">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680322">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680510">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680661">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680901">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000680993">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681024">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681206">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681318">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681613">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000681683">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000682324">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000682366">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000683097">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044423">
        <property type="term" value="C:virion component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04059">
        <property type="entry name" value="ADV_PRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000855">
        <property type="entry name" value="Peptidase_C5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00770">
        <property type="entry name" value="Peptidase_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001218">
        <property type="entry name" value="Protease_ADV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00703">
        <property type="entry name" value="ADVENDOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="2 6 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 6" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 7" id="KW-0426">Late protein</keyword>
    <keyword evidence="6 7 11" id="KW-0645">Protease</keyword>
    <keyword evidence="42" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0946">Virion</keyword>
    <feature type="active site" evidence="6 8">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="6">
        <location>
            <begin position="57"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with C-10 in cleaved protease cofactor pVI-C)" evidence="6">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001218-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAW33169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAW33261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB17804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ANQ44539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="QTW00103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="QTW00140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="QTW00177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="QTW00214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="QTW00251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="QTW00288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="QTW00325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="QTW00362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="QTW00399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="QTW00436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="QTW00473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="QTW00510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="QTW00547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="QTW00584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="QTW00621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="QTW00658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="QTW00695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="EMBL" id="QTW00732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="QTW00769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="QTW00806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="QTW00843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="QTW00880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="EMBL" id="QTW00917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="QTW00991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="EMBL" id="QTW01028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="38">
        <source>
            <dbReference type="EMBL" id="QTW01102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="39">
        <source>
            <dbReference type="EMBL" id="QTW01139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="40">
        <source>
            <dbReference type="EMBL" id="QTW01176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="41">
        <source>
            <dbReference type="EMBL" id="QTW01213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="42">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="43">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="44">
        <source>
            <dbReference type="Proteomes" id="UP000126446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="45">
        <source>
            <dbReference type="Proteomes" id="UP000320097"/>
        </source>
    </evidence>
    <sequence length="209" mass="23808" checksum="AFF2BAA48BEE074B" modified="2005-12-20" version="1">MTCGSGNGSSEQELKAIVRDLGCGPYFLGTFDKRFPGFMAPDKLACAIVNTAGRETGGEHWLAFGWNPRYNTCYLFDPFGFSDERLKQIYQFEYEGLLRRSALATKDRCITLEKSTQSVQGPRSAACGLFCCMFLHAFVHWPDRPMDGNPTMKLLTGVSNSMLQSPQVQPTLRRNQEVLYRFLNTHSSYFRSHRARIERATAFDRMDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0H5</accession>
    <name>Q2Y0H5_ADE03</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pre-protein VI</fullName>
            <shortName evidence="5">pVI</shortName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="5">Endosome lysis protein</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="5">Protease cofactor</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="5">pVI-C</fullName>
            </alternativeName>
        </component>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">L3</name>
    </gene>
    <organism evidence="8 10">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="8 10" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="7 9" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">GB</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endosome lysis protein: Structural component of the virion that provides increased stability to the particle shell through its interaction with the core-capsid bridging protein and the hexon-linking protein VIII. Fibers shedding during virus entry into host cell allows the endosome lysis protein to be exposed as a membrane-lytic peptide. Exhibits pH-independent membrane fragmentation activity and probably mediates viral rapid escape from host endosome via organellar membrane lysis. It is not clear if it then remains partially associated with the capsid and involved in the intracellular microtubule-dependent transport of capsid to the nucleus, or if it is lost during endosomal penetration.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Pre-protein VI: During virus assembly, promotes hexon trimers nuclear import through nuclear pore complexes via an importin alpha/beta-dependent mechanism. By analogy to herpesviruses capsid assembly, might act as a chaperone to promote the formation of the icosahedral capsid.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Protease cofactor: Cofactor that activates the viral protease. Binds to viral protease in a 1:1 ratio.</text>
    </comment>
    <comment type="subunit">
        <molecule>Endosome lysis protein</molecule>
        <text evidence="5">Interacts (via PPxY motif) with host NEDD4 ubiquitine ligase; this interaction might play a role in virus intracellular transport during entry. Part of a complex composed of the core-capsid bridging protein, the endosome lysis protein VI and the hexon-linking protein VIII; these interactions bridge the virus core to the capsid. Interacts with peripentonal hexons; this interaction stabilizes the capsid by gluing two peripentonal hexons together and joining them with an adjacent group-of-nine hexon.</text>
    </comment>
    <comment type="subunit">
        <molecule>Pre-protein VI</molecule>
        <text evidence="5">Interacts with hexon protein; this interaction allows nuclear import of hexon trimers and possibly pre-capsid assembly. Interacts (via C-terminal NLS) with importin alpha/beta.</text>
    </comment>
    <comment type="subunit">
        <molecule>Protease cofactor</molecule>
        <text evidence="5">Heterodimer with the viral protease; disulfide-linked. Interacts with the viral protease.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Pre-protein VI</molecule>
        <subcellularLocation>
            <location evidence="5">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Host cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">Shuttles between host cytoplasm and nucleus.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Endosome lysis protein</molecule>
        <subcellularLocation>
            <location evidence="5">Virion</location>
        </subcellularLocation>
        <text evidence="5">Associates with the base of each peripentonal hexon on the capsid interior. Present in around 360 copies per virion.</text>
    </comment>
    <comment type="induction">
        <text evidence="5">Expressed in the late phase of the viral replicative cycle.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">Late-budding domains (L domains) are short sequence motifs essential for viral particle release. They can occur individually or in close proximity within structural proteins. They interacts with sorting cellular proteins of the multivesicular body (MVB) pathway. Most of these proteins are class E vacuolar protein sorting factors belonging to ESCRT-I, ESCRT-II or ESCRT-III complexes. Minor capsid protein 6 contains one L domain: a PPXY motif which binds to the WW domains of HECT (homologous to E6-AP C-terminus) E3 ubiquitin ligases, like NEDD4. In adenoviruses, this motif seems to play a role in microtubule-dependent intracellular trafficking toward the nucleus during virus entry into host cell and in suppression of DAXX-mediated repression of the immediate early E1A promoter.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">N-terminal amphipathic alpha-helix domain is essential for the membrane lytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Protease cofactor: Contains the major nuclear import and export signals. Proteolytically removed during virion maturation. The processing of the C-terminus turns the precursor into a mature viral structural protein and abrogates its ability to promote hexon import and act as a potential chaperone protein.</text>
    </comment>
    <comment type="PTM">
        <text evidence="5">Ubiquitinated by Nedd4 following partial capsid disassembly; which might play a role in intracellular virus movement during entry.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="5">All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adenoviridae protein VI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042025">
        <property type="term" value="C:host cell nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046729">
        <property type="term" value="C:viral procapsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039664">
        <property type="term" value="P:lysis of host organelle involved in viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075521">
        <property type="term" value="P:microtubule-dependent intracellular transport of viral material towards nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019076">
        <property type="term" value="P:viral release from host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04048">
        <property type="entry name" value="ADV_CAP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004243">
        <property type="entry name" value="McpVI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02993">
        <property type="entry name" value="MCPVI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="5" id="KW-0167">Capsid protein</keyword>
    <keyword evidence="5" id="KW-1176">Cytoplasmic inwards viral transport</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 5" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="5" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="5" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="5" id="KW-0426">Late protein</keyword>
    <keyword evidence="5" id="KW-1177">Microtubular inwards viral transport</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="5" id="KW-0118">Viral capsid assembly</keyword>
    <keyword evidence="1 5" id="KW-1162">Viral penetration into host cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-1174">Viral penetration via lysis of host organellar membrane</keyword>
    <keyword evidence="2 5" id="KW-1188">Viral release from host cell</keyword>
    <keyword evidence="5" id="KW-0946">Virion</keyword>
    <keyword evidence="5" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="chain" id="PRO_5035345150" description="Pre-protein VI" evidence="5">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_5035345152" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035345151" description="Endosome lysis protein" evidence="5">
        <location>
            <begin position="34"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035345149" description="Protease cofactor" evidence="5">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amphipathic alpha-helix essential for membrane lytic activity" evidence="5">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in endosomal membrane lysis" evidence="5">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with hexon protein" evidence="5">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="174"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with hexon protein" evidence="5">
        <location>
            <begin position="233"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Binds to importin alpha/beta, involved in hexon nuclear import" evidence="5">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear export signal" evidence="5">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal" evidence="5">
        <location>
            <begin position="132"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PPXY motif" evidence="5">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear export signal" evidence="5">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nuclear localization signal" evidence="5">
        <location>
            <begin position="245"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by viral protease" evidence="5">
        <location>
            <begin position="33"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by viral protease" evidence="5">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by host" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with Adenovirus protease)" evidence="5">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAW33167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB17802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="250" mass="27128" checksum="4989B3D98FC04C1D" modified="2005-12-20" version="1">MEDINFSSLAPRHGTRPYMGTWSDIGTSQLNGGAFNWSSIWSGLKNFGSTVKTYGNKAWNSSTGQALRNKLKEQNFQQKVVDGIASGINGVVDLANQAVQKQINSRLDPPPATPGEMEVEEELPPLEKRGDKRPRPELEQTLVTRADEPPSYEEAVKLGMPTTRPVAHMATGVMKPSQSHRPATLDLPPPPASAAPVPKPVATRKPTAVQPVAVARPRPGGTPRPKANWQSTLNSIVGLGVQSVKRRRCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0H7</accession>
    <name>Q2Y0H7_ADE03</name>
    <protein>
        <submittedName>
            <fullName evidence="5">L2 protein pV</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Protein V</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">L2</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">GB</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenoviridae core-capsid bridging protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044423">
        <property type="term" value="C:virion component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005608">
        <property type="entry name" value="Adeno_V"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03910">
        <property type="entry name" value="Adeno_PV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0426">Late protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAW33166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB17801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="349" mass="40171" checksum="45E12B5B8DBBB6EA" modified="2005-12-20" version="1">MSKRKYKEEMLQVIAPEIYGPPVKDEKKPRKIKRVKNNKKEEDDDDGLVEFVREFAPRRRVQWRGRKVRQVLRPGTTVVFTPGERSSTTFKRSYDEVYGDDDILEQAADRLDEFAYGKRTRSSPKEEAVSIPLDHGNPTPSLKPVTLQQVLPVPARRGVKREGEDLYPTMQLMVPKRQRLEDVLEKMKVDADIQPEVKVRPIKEVAPGLGVQTFDIKIPTESMEVQTEPAKPTTSIEVQTEPWMPAPVAAPSTTRRSRRKYGPASLLMPNYALHPSIIPTPGYRGTRYYRNRSNTSRRRKPPASRTRRRRRRNTASKLTPAALVRRVYRDGRAEPLTLPRARYHPSITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0H8</accession>
    <name>Q2Y0H8_ADE03</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-histone-like nucleoprotein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pre-core protein VII</fullName>
            <shortName evidence="3">pVII</shortName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="3">Histone-like nucleoprotein</fullName>
                <shortName evidence="3">NP</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Core protein VII</fullName>
            </alternativeName>
        </component>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">L2</name>
    </gene>
    <organism evidence="5 7">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="5 7" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="4 6" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">GB</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the inhibition of host immune response within the nucleus. Interacts with cellular nucleosomes and immobilizes the host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1 release out of the cell and thus decreases inflammation. Plays also a role in the wrapping and condensation of the viral DNA. May also promote viral genome import into the nucleus.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with the core-capsid bridging protein; this interaction bridges the virus core to the capsid. Interacts with host NPM1; this interaction might play a role in placing the pre-histone-like nucleoprotein on the viral DNA or regulating viral gene expression. Interacts with host HMGB1; this interaction inhibits host immune response.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Histone-like nucleoprotein</molecule>
        <subcellularLocation>
            <location evidence="3">Virion</location>
        </subcellularLocation>
        <text evidence="3">Located inside the capsid in association with the viral DNA (core). Present in about 1070 copies per virion.</text>
    </comment>
    <comment type="subcellular location">
        <molecule>Pre-histone-like nucleoprotein</molecule>
        <subcellularLocation>
            <location evidence="3">Host nucleus</location>
            <location evidence="3">Host nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="3">Expressed in the late phase of the viral replicative cycle.</text>
    </comment>
    <comment type="PTM">
        <text evidence="3">Cleaved near the N-terminus by the viral protease during virion maturation to form the mature protein.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="3">All late proteins expressed from the major late promoter are produced by alternative splicing and alternative polyadenylation of the same gene giving rise to non-overlapping ORFs. A leader sequence is present in the N-terminus of all these mRNAs and is recognized by the viral shutoff protein to provide expression although conventional translation via ribosome scanning from the cap has been shut off in the host cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the adenoviridae histone-like nucleoprotein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044196">
        <property type="term" value="C:host cell nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075732">
        <property type="term" value="P:viral penetration into host nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_04056">
        <property type="entry name" value="ADV_PVII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004912">
        <property type="entry name" value="Adeno_VII"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03228">
        <property type="entry name" value="Adeno_VII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="3" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="3" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="3" id="KW-0426">Late protein</keyword>
    <keyword evidence="2 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-1163">Viral penetration into host nucleus</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <keyword evidence="3" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="initiator methionine" description="Removed" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035346387" description="Pre-histone-like nucleoprotein" evidence="3">
        <location>
            <begin position="2"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="propeptide" id="PRO_5035346386" evidence="3">
        <location>
            <begin position="2"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5035346388" description="Histone-like nucleoprotein" evidence="3">
        <location>
            <begin position="25"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by viral protease" evidence="3">
        <location>
            <begin position="24"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylserine; by host" evidence="3">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; by host" evidence="3">
        <location>
            <position position="27"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-acetyllysine; by host" evidence="3">
        <location>
            <position position="48"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by host" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAW33165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB17800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="192" mass="21233" checksum="8ED784BBF11AA97B" modified="2005-12-20" version="1">MSILISPSNNTGWGLYAPTKMYGGARKRSTQHPVRVRGHFRAPWGALKGRTRTRTTVDDVIDQVVADARNYTPTAPTSTVDAVIDSVVADARAYARRKSRRRRIARRHRATPAMRAAKAILRRAKRVGRRAMLRAARRAASGASSGRSRRRAATAAAAAIANMAQPRRGNVYWVRDATTGQRVPVRTRPPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-12-20" modified="2022-08-03" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q2Y0J3</accession>
    <name>Q2Y0J3_ADE03</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">E1B protein, small T-antigen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">E1B</name>
        <name evidence="8" type="synonym">EIB</name>
    </gene>
    <organism evidence="9 12">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="9 12" key="1">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="8 11" key="2">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">GB</strain>
        </source>
    </reference>
    <reference evidence="10" key="3">
        <citation type="submission" date="2021-03" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Duan Y."/>
                <person name="Zhu Y."/>
                <person name="Chen X."/>
                <person name="Xie Z."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">ZJ20150111</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Putative adenovirus Bcl-2 homolog that inhibits apoptosis induced by TNF or FAS pathways, as well as p53-mediated apoptosis. Without E1B 19K function, virus production is compromised because of premature death of host cell. Interacts with Bax protein in cell lysates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Host cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Host nucleus envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Host nucleus lamina</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the adenoviridae E1B 19 kDa protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="MW748671">
        <property type="protein sequence ID" value="QTW01162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000678455">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044203">
        <property type="term" value="C:host cell nuclear lamina"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019050">
        <property type="term" value="P:suppression by virus of host apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002924">
        <property type="entry name" value="Adenovir_t-Ag_E1B_19kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002475">
        <property type="entry name" value="Bcl2-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01691">
        <property type="entry name" value="Adeno_E1B_19K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50062">
        <property type="entry name" value="BCL2_FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3 7" id="KW-0244">Early protein</keyword>
    <keyword evidence="7" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="7" id="KW-1043">Host membrane</keyword>
    <keyword evidence="7" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="4 7" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="5 7" id="KW-1081">Inhibition of host apoptosis by viral BCL2-like protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 7" id="KW-1119">Modulation of host cell apoptosis by virus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAW33152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB17770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="QTW01162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="178" mass="20521" checksum="AE902B4E7F018238" modified="2005-12-20" version="1">MEVWAILEDLRQTKLLLENASDGVSGLWRFWFGGDLARLVFRIKQDYREEFEKLLDDSPGLFEALNLGHQAHFKEKVLSVLDFSTPGRTAAAVAFLTFILDKWIRQTHFSKGYVLDFIAAALWRTWKARRMRTILDYWPVQPLGVAGILRHPPTMPAVLQEEQQEDNPRAGLDPPVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2002-10-01" modified="2022-08-03" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q8JSK3</accession>
    <name>Q8JSK3_ADE03</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Early E1A protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">E1A</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Human adenovirus B serotype 3</name>
        <name type="common">HAdV-3</name>
        <name type="synonym">Human adenovirus 3</name>
        <dbReference type="NCBI Taxonomy" id="45659"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Preplasmiviricota</taxon>
            <taxon>Tectiliviricetes</taxon>
            <taxon>Rowavirales</taxon>
            <taxon>Adenoviridae</taxon>
            <taxon>Mastadenovirus</taxon>
            <taxon>Human mastadenovirus B</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2002" name="J. Virol." volume="76" first="7968" last="7975">
            <title>Comparative sequence analysis of the largest E1A proteins of human and simian adenoviruses.</title>
            <authorList>
                <person name="Avvakumov N."/>
                <person name="Wheeler R."/>
                <person name="D'Halluin J.C."/>
                <person name="Mymryk J.S."/>
            </authorList>
            <dbReference type="PubMed" id="12134001"/>
            <dbReference type="DOI" id="10.1128/JVI.76.16.7968-7975.2002"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
    </reference>
    <reference evidence="6 8" key="2">
        <citation type="journal article" date="2005" name="Virology" volume="343" first="283" last="298">
            <title>The nucleotide sequence and a first generation gene transfer vector of species B human adenovirus serotype 3.</title>
            <authorList>
                <person name="Sirena D."/>
                <person name="Ruzsics Z."/>
                <person name="Schaffner W."/>
                <person name="Greber U.F."/>
                <person name="Hemmi S."/>
            </authorList>
            <dbReference type="PubMed" id="16169033"/>
            <dbReference type="DOI" id="10.1016/j.virol.2005.08.024"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference evidence="5 7" key="3">
        <citation type="journal article" date="2006" name="Genome Res." volume="16" first="527" last="535">
            <title>Broad-spectrum respiratory tract pathogen identification using resequencing DNA microarrays.</title>
            <authorList>
                <person name="Lin B."/>
                <person name="Wang Z."/>
                <person name="Vora G.J."/>
                <person name="Thornton J.A."/>
                <person name="Schnur J.M."/>
                <person name="Thach D.C."/>
                <person name="Blaney K.M."/>
                <person name="Ligler A.G."/>
                <person name="Malanoski A.P."/>
                <person name="Santiago J."/>
                <person name="Walter E.A."/>
                <person name="Agan B.K."/>
                <person name="Metzgar D."/>
                <person name="Seto D."/>
                <person name="Daum L.T."/>
                <person name="Kruzelock R."/>
                <person name="Rowley R.K."/>
                <person name="Hanson E.H."/>
                <person name="Tibbetts C."/>
                <person name="Stenger D.A."/>
            </authorList>
            <dbReference type="PubMed" id="16481660"/>
            <dbReference type="DOI" id="10.1101/gr.4337206"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">GB</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adenoviridae E1A protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AF492352">
        <property type="protein sequence ID" value="AAM46820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY599834">
        <property type="protein sequence ID" value="AAW33151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="DQ086466">
        <property type="protein sequence ID" value="ABB17768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000108010">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000113319">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039645">
        <property type="term" value="P:modulation by virus of host G1/S transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014410">
        <property type="entry name" value="Aden_E1A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02703">
        <property type="entry name" value="Adeno_E1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003669">
        <property type="entry name" value="Aden_E1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0244">Early protein</keyword>
    <keyword evidence="2" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0899">Viral immunoevasion</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="156"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR003669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAM46820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAW33151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB17768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000108010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000113319"/>
        </source>
    </evidence>
    <sequence length="230" mass="24648" checksum="06670AFFBB04D01D" modified="2002-10-01" version="1">MRHLRFLPQEVISSETGIEILEFVVNTLMGDDPEPPVQPFDPPTLHDLYDLEIDGPEDPNEEAVNGFFTDSMLLAADEGLDINPPPETLVTPGVVVESGIGGKKLPDLGAAEMDLRCYEEGFPPSDDEDGETEQSIHTAVNEGVKAASDVFKLDCPELPGHGCPVSDDESPSPDSTTSPPEIQAPAPANVCKPIPVKPKPGKRPAVDKLEDLLEGGDGPLDLSTRKLPRQ</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>