<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="Swiss-Prot" created="1989-07-01" modified="2022-02-23" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>P09715-2</accession>
    <name>IRS1_HCMVA</name>
    <protein>
        <recommendedName>
            <fullName>Isoform IRS1-263 of Protein IRS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>HQRF1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">IRS1</name>
    </gene>
    <organism>
        <name type="scientific">Human cytomegalovirus (strain AD169)</name>
        <name type="common">HHV-5</name>
        <name type="synonym">Human herpesvirus 5</name>
        <dbReference type="NCBI Taxonomy" id="10360"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Cytomegalovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1986" name="J. Mol. Biol." volume="192" first="177" last="208">
            <title>Sequence of the short unique region, short repeats, and part of the long repeats of human cytomegalovirus.</title>
            <authorList>
                <person name="Weston K.M."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="3031311"/>
            <dbReference type="DOI" id="10.1016/0022-2836(86)90359-1"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1990" name="Curr. Top. Microbiol. Immunol." volume="154" first="125" last="169">
            <title>Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Bankier A.T."/>
                <person name="Beck S."/>
                <person name="Bohni R."/>
                <person name="Brown C.M."/>
                <person name="Cerny R."/>
                <person name="Horsnell T."/>
                <person name="Hutchison C.A.III."/>
                <person name="Kouzarides T."/>
                <person name="Martignetti J.A."/>
            </authorList>
            <dbReference type="PubMed" id="2161319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1997" name="J. Virol." volume="71" first="1485" last="1496">
            <title>Characterization of the human cytomegalovirus irs1 and trs1 genes: a second immediate-early transcription unit within irs1 whose product antagonizes transcriptional activation.</title>
            <authorList>
                <person name="Romanowski M.J."/>
                <person name="Shenk T."/>
            </authorList>
            <dbReference type="PubMed" id="8995674"/>
        </citation>
        <scope>ISOFORM IRS1-263</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="17" last="28">
            <title>The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.</title>
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
            <dbReference type="PubMed" id="12533697"/>
            <dbReference type="DOI" id="10.1099/vir.0.18606-0"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="1053" last="1053">
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:8995674</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="10960" last="10966">
            <title>Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome.</title>
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
            <dbReference type="PubMed" id="15452216"/>
            <dbReference type="DOI" id="10.1128/JVI.78.20.10960-10966.2004"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="13395" last="13395">
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:15452216</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2006" name="J. Virol." volume="80" first="11817" last="11826">
            <title>Binding and nuclear relocalization of protein kinase R by human cytomegalovirus TRS1.</title>
            <authorList>
                <person name="Hakki M."/>
                <person name="Marshall E.E."/>
                <person name="De Niro K.L."/>
                <person name="Geballe A.P."/>
            </authorList>
            <dbReference type="PubMed" id="16987971"/>
            <dbReference type="DOI" id="10.1128/JVI.00957-06"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HOST EIF2AK2</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2009" name="J. Virol." volume="83" first="4112" last="4120">
            <title>Essential role for either TRS1 or IRS1 in human cytomegalovirus replication.</title>
            <authorList>
                <person name="Marshall E.E."/>
                <person name="Bierle C.J."/>
                <person name="Brune W."/>
                <person name="Geballe A.P."/>
            </authorList>
            <dbReference type="PubMed" id="19211736"/>
            <dbReference type="DOI" id="10.1128/JVI.02489-08"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2010" name="J. Gen. Virol." volume="91" first="2167" last="2175">
            <title>Association of human cytomegalovirus proteins IRS1 and TRS1 with the viral DNA polymerase accessory subunit UL44.</title>
            <authorList>
                <person name="Strang B.L."/>
                <person name="Geballe A.P."/>
                <person name="Coen D.M."/>
            </authorList>
            <dbReference type="PubMed" id="20444996"/>
            <dbReference type="DOI" id="10.1099/vir.0.022640-0"/>
        </citation>
        <scope>INTERACTION WITH UL44</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative initiation"/>
        <isoform>
            <id>P09715-1</id>
            <name>IRS1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P09715-2</id>
            <name>IRS1-263</name>
            <sequence type="described" ref="VSP_043923"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000008991">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008992">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="263" mass="30102" checksum="FCB346DC5B5F6B55" modified="1989-07-01" version="1">MTERQSQLPEKYIGFYQIRKPPWLMEQPPPPSRQTKPDAATMPPPLSAQASVSYALRYDDESWRPLSTVDDHKAWLDLDESHWVLGDSRPDDIKQRRLLKATQRRGAEIDRPMPVVPEECYDQRFTTEGHQVIPLCASEPEDDDEDPTYDELPSRPPQKHKPPDKPPRLCKTGPGPPPLPPKQRHGSTDGKVSAPRQSEHHKRQTRPPRPPPPKFGDRTAAHLSQNMRDMYLDMCTSSGHRPRPPAPPRPKKCQTHAPHHVHH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>P16753-2</accession>
    <name>SCAF_HCMVA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform pAP of Capsid scaffolding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protease precursor</fullName>
            <shortName evidence="1">pPR</shortName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">Assemblin</fullName>
                <ecNumber evidence="1">3.4.21.97</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Protease</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Assembly protein</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Capsid assembly protein</fullName>
            </alternativeName>
        </component>
    </protein>
    <gene>
        <name type="primary">UL80</name>
        <name type="synonym">APNG</name>
    </gene>
    <organism>
        <name type="scientific">Human cytomegalovirus (strain AD169)</name>
        <name type="common">HHV-5</name>
        <name type="synonym">Human herpesvirus 5</name>
        <dbReference type="NCBI Taxonomy" id="10360"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Cytomegalovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="Curr. Top. Microbiol. Immunol." volume="154" first="125" last="169">
            <title>Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Bankier A.T."/>
                <person name="Beck S."/>
                <person name="Bohni R."/>
                <person name="Brown C.M."/>
                <person name="Cerny R."/>
                <person name="Horsnell T."/>
                <person name="Hutchison C.A.III."/>
                <person name="Kouzarides T."/>
                <person name="Martignetti J.A."/>
            </authorList>
            <dbReference type="PubMed" id="2161319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="Nature" volume="383" first="272" last="275">
            <title>A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease.</title>
            <authorList>
                <person name="Tong L."/>
                <person name="Qian C."/>
                <person name="Massariol M.-J."/>
                <person name="Bonneau P.R."/>
                <person name="Cordingley M.G."/>
                <person name="Lagace L."/>
            </authorList>
            <dbReference type="PubMed" id="8805706"/>
            <dbReference type="DOI" id="10.1038/383272a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF PROTEASE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1996" name="Nature" volume="383" first="275" last="279">
            <title>Unique fold and active site in cytomegalovirus protease.</title>
            <authorList>
                <person name="Qiu X."/>
                <person name="Culp J.S."/>
                <person name="Dilella A.G."/>
                <person name="Hellmig B."/>
                <person name="Hoog S.S."/>
                <person name="Janson C.A."/>
                <person name="Smith W.W."/>
                <person name="Abdel-Meguid S.A."/>
            </authorList>
            <dbReference type="PubMed" id="8805707"/>
            <dbReference type="DOI" id="10.1038/383275a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF PROTEASE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1996" name="Nature" volume="383" first="279" last="282">
            <title>Three-dimensional structure of human cytomegalovirus protease.</title>
            <authorList>
                <person name="Shieh H.-S."/>
                <person name="Kurumbail R.G."/>
                <person name="Stevens A.M."/>
                <person name="Stegeman R.A."/>
                <person name="Sturman E.J."/>
                <person name="Pak J.Y."/>
                <person name="Wittwer A.J."/>
                <person name="Palmier M.O."/>
                <person name="Wiegand R.C."/>
                <person name="Holwerda B.C."/>
                <person name="Stallings W.C."/>
            </authorList>
            <dbReference type="PubMed" id="8805708"/>
            <dbReference type="DOI" id="10.1038/383279a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF PROTEASE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1997" name="J. Virol." volume="71" first="179" last="190">
            <title>Human cytomegalovirus capsid assembly protein precursor (pUL80.5) interacts with itself and with the major capsid protein (pUL86) through two different domains.</title>
            <authorList>
                <person name="Wood L.J."/>
                <person name="Baxter M.K."/>
                <person name="Plafker S.M."/>
                <person name="Gibson W."/>
            </authorList>
            <dbReference type="PubMed" id="8985337"/>
        </citation>
        <scope>MULTIMERIZATION</scope>
        <scope>INTERACTION WITH UL86</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="17" last="28">
            <title>The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.</title>
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
            <dbReference type="PubMed" id="12533697"/>
            <dbReference type="DOI" id="10.1099/vir.0.18606-0"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="1053" last="1053">
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:12533697</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="10960" last="10966">
            <title>Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome.</title>
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
            <dbReference type="PubMed" id="15452216"/>
            <dbReference type="DOI" id="10.1128/JVI.78.20.10960-10966.2004"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="13395" last="13395">
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:15452216</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2008" name="Curr. Top. Microbiol. Immunol." volume="325" first="187" last="204">
            <title>Structure and formation of the cytomegalovirus virion.</title>
            <authorList>
                <person name="Gibson W."/>
            </authorList>
            <dbReference type="PubMed" id="18637507"/>
        </citation>
        <scope>REVIEW</scope>
        <scope>ISOFORM UL80.4 PROTEIN AND UL80.3 PROTEIN</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative promoter"/>
        <isoform>
            <id>P16753-3</id>
            <name>UL80.4 protein</name>
            <sequence type="described" ref="VSP_037424"/>
        </isoform>
        <isoform>
            <id>P16753-4</id>
            <name>UL80.3 protein</name>
            <sequence type="described" ref="VSP_037425"/>
        </isoform>
        <isoform>
            <id>P16753-2</id>
            <name>pAP</name>
            <name>Assembly protein</name>
            <name>UL80.5</name>
            <sequence type="described" ref="VSP_037423"/>
        </isoform>
        <isoform>
            <id>P16753-1</id>
            <name>Capsid scaffolding protein</name>
            <name>UL80a</name>
            <name>pPR</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.21.97" evidence="1"/>
    <dbReference type="Proteomes" id="UP000008991">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008992">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04008"/>
        </source>
    </evidence>
    <sequence length="373" mass="38252" checksum="E98A2DA99A5E1597" modified="1990-08-01" version="1">MSHPLSAAVPAATAPPGATVAGASPAVSSLAWPHDGVYLPKDAFFSLLGASRSAVPVMYPGAVAAPPSASPAPLPLPSYPASYGAPVVGYDQLAARHFADYVDPHYPGWGRRYEPAPSLHPSYPVPPPPSPAYYRRRDSPGGMDEPPSGWERYDGGHRGQSQKQHRHGGSGGHNKRRKETAAASSSSSDEDLSFPGEAEHGRARKRLKSHVNSDGGSGGHAGSNQQQQQRYDELRDAIHELKRDLFAARQSSTLLSAALPSAASSSPTTTTVCTPTGELTSGGGETPTALLSGGAKVAERAQAGVVNASCRLATASGSEAATAGPSTAGSSSCPASVVLAAAAAQAAAASQSPPKDMVDLNRRIFVAALNKLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>P16753-3</accession>
    <name>SCAF_HCMVA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform UL80.4 protein of Capsid scaffolding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protease precursor</fullName>
            <shortName evidence="1">pPR</shortName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">Assemblin</fullName>
                <ecNumber evidence="1">3.4.21.97</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Protease</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Assembly protein</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Capsid assembly protein</fullName>
            </alternativeName>
        </component>
    </protein>
    <gene>
        <name type="primary">UL80</name>
        <name type="synonym">APNG</name>
    </gene>
    <organism>
        <name type="scientific">Human cytomegalovirus (strain AD169)</name>
        <name type="common">HHV-5</name>
        <name type="synonym">Human herpesvirus 5</name>
        <dbReference type="NCBI Taxonomy" id="10360"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Cytomegalovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="Curr. Top. Microbiol. Immunol." volume="154" first="125" last="169">
            <title>Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Bankier A.T."/>
                <person name="Beck S."/>
                <person name="Bohni R."/>
                <person name="Brown C.M."/>
                <person name="Cerny R."/>
                <person name="Horsnell T."/>
                <person name="Hutchison C.A.III."/>
                <person name="Kouzarides T."/>
                <person name="Martignetti J.A."/>
            </authorList>
            <dbReference type="PubMed" id="2161319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="Nature" volume="383" first="272" last="275">
            <title>A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease.</title>
            <authorList>
                <person name="Tong L."/>
                <person name="Qian C."/>
                <person name="Massariol M.-J."/>
                <person name="Bonneau P.R."/>
                <person name="Cordingley M.G."/>
                <person name="Lagace L."/>
            </authorList>
            <dbReference type="PubMed" id="8805706"/>
            <dbReference type="DOI" id="10.1038/383272a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF PROTEASE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1996" name="Nature" volume="383" first="275" last="279">
            <title>Unique fold and active site in cytomegalovirus protease.</title>
            <authorList>
                <person name="Qiu X."/>
                <person name="Culp J.S."/>
                <person name="Dilella A.G."/>
                <person name="Hellmig B."/>
                <person name="Hoog S.S."/>
                <person name="Janson C.A."/>
                <person name="Smith W.W."/>
                <person name="Abdel-Meguid S.A."/>
            </authorList>
            <dbReference type="PubMed" id="8805707"/>
            <dbReference type="DOI" id="10.1038/383275a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF PROTEASE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1996" name="Nature" volume="383" first="279" last="282">
            <title>Three-dimensional structure of human cytomegalovirus protease.</title>
            <authorList>
                <person name="Shieh H.-S."/>
                <person name="Kurumbail R.G."/>
                <person name="Stevens A.M."/>
                <person name="Stegeman R.A."/>
                <person name="Sturman E.J."/>
                <person name="Pak J.Y."/>
                <person name="Wittwer A.J."/>
                <person name="Palmier M.O."/>
                <person name="Wiegand R.C."/>
                <person name="Holwerda B.C."/>
                <person name="Stallings W.C."/>
            </authorList>
            <dbReference type="PubMed" id="8805708"/>
            <dbReference type="DOI" id="10.1038/383279a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF PROTEASE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1997" name="J. Virol." volume="71" first="179" last="190">
            <title>Human cytomegalovirus capsid assembly protein precursor (pUL80.5) interacts with itself and with the major capsid protein (pUL86) through two different domains.</title>
            <authorList>
                <person name="Wood L.J."/>
                <person name="Baxter M.K."/>
                <person name="Plafker S.M."/>
                <person name="Gibson W."/>
            </authorList>
            <dbReference type="PubMed" id="8985337"/>
        </citation>
        <scope>MULTIMERIZATION</scope>
        <scope>INTERACTION WITH UL86</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="17" last="28">
            <title>The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.</title>
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
            <dbReference type="PubMed" id="12533697"/>
            <dbReference type="DOI" id="10.1099/vir.0.18606-0"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="1053" last="1053">
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:12533697</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="10960" last="10966">
            <title>Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome.</title>
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
            <dbReference type="PubMed" id="15452216"/>
            <dbReference type="DOI" id="10.1128/JVI.78.20.10960-10966.2004"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="13395" last="13395">
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:15452216</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2008" name="Curr. Top. Microbiol. Immunol." volume="325" first="187" last="204">
            <title>Structure and formation of the cytomegalovirus virion.</title>
            <authorList>
                <person name="Gibson W."/>
            </authorList>
            <dbReference type="PubMed" id="18637507"/>
        </citation>
        <scope>REVIEW</scope>
        <scope>ISOFORM UL80.4 PROTEIN AND UL80.3 PROTEIN</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative promoter"/>
        <isoform>
            <id>P16753-1</id>
            <name>Capsid scaffolding protein</name>
            <name>UL80a</name>
            <name>pPR</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P16753-2</id>
            <name>pAP</name>
            <name>UL80.5</name>
            <name>Assembly protein</name>
            <sequence type="described" ref="VSP_037423"/>
        </isoform>
        <isoform>
            <id>P16753-4</id>
            <name>UL80.3 protein</name>
            <sequence type="described" ref="VSP_037425"/>
        </isoform>
        <isoform>
            <id>P16753-3</id>
            <name>UL80.4 protein</name>
            <sequence type="described" ref="VSP_037424"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.21.97" evidence="1"/>
    <dbReference type="Proteomes" id="UP000008991">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008992">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04008"/>
        </source>
    </evidence>
    <sequence length="316" mass="32700" checksum="7E2E5EC4F9E51BF5" modified="1990-08-01" version="1">MYPGAVAAPPSASPAPLPLPSYPASYGAPVVGYDQLAARHFADYVDPHYPGWGRRYEPAPSLHPSYPVPPPPSPAYYRRRDSPGGMDEPPSGWERYDGGHRGQSQKQHRHGGSGGHNKRRKETAAASSSSSDEDLSFPGEAEHGRARKRLKSHVNSDGGSGGHAGSNQQQQQRYDELRDAIHELKRDLFAARQSSTLLSAALPSAASSSPTTTTVCTPTGELTSGGGETPTALLSGGAKVAERAQAGVVNASCRLATASGSEAATAGPSTAGSSSCPASVVLAAAAAQAAAASQSPPKDMVDLNRRIFVAALNKLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>P16753-4</accession>
    <name>SCAF_HCMVA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform UL80.3 protein of Capsid scaffolding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Protease precursor</fullName>
            <shortName evidence="1">pPR</shortName>
        </alternativeName>
        <component>
            <recommendedName>
                <fullName evidence="1">Assemblin</fullName>
                <ecNumber evidence="1">3.4.21.97</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Protease</fullName>
            </alternativeName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Assembly protein</fullName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">Capsid assembly protein</fullName>
            </alternativeName>
        </component>
    </protein>
    <gene>
        <name type="primary">UL80</name>
        <name type="synonym">APNG</name>
    </gene>
    <organism>
        <name type="scientific">Human cytomegalovirus (strain AD169)</name>
        <name type="common">HHV-5</name>
        <name type="synonym">Human herpesvirus 5</name>
        <dbReference type="NCBI Taxonomy" id="10360"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Cytomegalovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="Curr. Top. Microbiol. Immunol." volume="154" first="125" last="169">
            <title>Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Bankier A.T."/>
                <person name="Beck S."/>
                <person name="Bohni R."/>
                <person name="Brown C.M."/>
                <person name="Cerny R."/>
                <person name="Horsnell T."/>
                <person name="Hutchison C.A.III."/>
                <person name="Kouzarides T."/>
                <person name="Martignetti J.A."/>
            </authorList>
            <dbReference type="PubMed" id="2161319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1996" name="Nature" volume="383" first="272" last="275">
            <title>A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease.</title>
            <authorList>
                <person name="Tong L."/>
                <person name="Qian C."/>
                <person name="Massariol M.-J."/>
                <person name="Bonneau P.R."/>
                <person name="Cordingley M.G."/>
                <person name="Lagace L."/>
            </authorList>
            <dbReference type="PubMed" id="8805706"/>
            <dbReference type="DOI" id="10.1038/383272a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF PROTEASE</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1996" name="Nature" volume="383" first="275" last="279">
            <title>Unique fold and active site in cytomegalovirus protease.</title>
            <authorList>
                <person name="Qiu X."/>
                <person name="Culp J.S."/>
                <person name="Dilella A.G."/>
                <person name="Hellmig B."/>
                <person name="Hoog S.S."/>
                <person name="Janson C.A."/>
                <person name="Smith W.W."/>
                <person name="Abdel-Meguid S.A."/>
            </authorList>
            <dbReference type="PubMed" id="8805707"/>
            <dbReference type="DOI" id="10.1038/383275a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF PROTEASE</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="1996" name="Nature" volume="383" first="279" last="282">
            <title>Three-dimensional structure of human cytomegalovirus protease.</title>
            <authorList>
                <person name="Shieh H.-S."/>
                <person name="Kurumbail R.G."/>
                <person name="Stevens A.M."/>
                <person name="Stegeman R.A."/>
                <person name="Sturman E.J."/>
                <person name="Pak J.Y."/>
                <person name="Wittwer A.J."/>
                <person name="Palmier M.O."/>
                <person name="Wiegand R.C."/>
                <person name="Holwerda B.C."/>
                <person name="Stallings W.C."/>
            </authorList>
            <dbReference type="PubMed" id="8805708"/>
            <dbReference type="DOI" id="10.1038/383279a0"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS) OF PROTEASE</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="1997" name="J. Virol." volume="71" first="179" last="190">
            <title>Human cytomegalovirus capsid assembly protein precursor (pUL80.5) interacts with itself and with the major capsid protein (pUL86) through two different domains.</title>
            <authorList>
                <person name="Wood L.J."/>
                <person name="Baxter M.K."/>
                <person name="Plafker S.M."/>
                <person name="Gibson W."/>
            </authorList>
            <dbReference type="PubMed" id="8985337"/>
        </citation>
        <scope>MULTIMERIZATION</scope>
        <scope>INTERACTION WITH UL86</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="17" last="28">
            <title>The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.</title>
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
            <dbReference type="PubMed" id="12533697"/>
            <dbReference type="DOI" id="10.1099/vir.0.18606-0"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="1053" last="1053">
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:12533697</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="10960" last="10966">
            <title>Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome.</title>
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
            <dbReference type="PubMed" id="15452216"/>
            <dbReference type="DOI" id="10.1128/JVI.78.20.10960-10966.2004"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="13395" last="13395">
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:15452216</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2008" name="Curr. Top. Microbiol. Immunol." volume="325" first="187" last="204">
            <title>Structure and formation of the cytomegalovirus virion.</title>
            <authorList>
                <person name="Gibson W."/>
            </authorList>
            <dbReference type="PubMed" id="18637507"/>
        </citation>
        <scope>REVIEW</scope>
        <scope>ISOFORM UL80.4 PROTEIN AND UL80.3 PROTEIN</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative promoter"/>
        <isoform>
            <id>P16753-4</id>
            <name>UL80.3 protein</name>
            <sequence type="described" ref="VSP_037425"/>
        </isoform>
        <isoform>
            <id>P16753-2</id>
            <name>pAP</name>
            <name>Assembly protein</name>
            <name>UL80.5</name>
            <sequence type="described" ref="VSP_037423"/>
        </isoform>
        <isoform>
            <id>P16753-3</id>
            <name>UL80.4 protein</name>
            <sequence type="described" ref="VSP_037424"/>
        </isoform>
        <isoform>
            <id>P16753-1</id>
            <name>Capsid scaffolding protein</name>
            <name>pPR</name>
            <name>UL80a</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="EC" id="3.4.21.97" evidence="1"/>
    <dbReference type="Proteomes" id="UP000008991">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008992">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04008"/>
        </source>
    </evidence>
    <sequence length="231" mass="23601" checksum="19D7AC8C58798835" modified="1990-08-01" version="1">MDEPPSGWERYDGGHRGQSQKQHRHGGSGGHNKRRKETAAASSSSSDEDLSFPGEAEHGRARKRLKSHVNSDGGSGGHAGSNQQQQQRYDELRDAIHELKRDLFAARQSSTLLSAALPSAASSSPTTTTVCTPTGELTSGGGETPTALLSGGAKVAERAQAGVVNASCRLATASGSEAATAGPSTAGSSSCPASVVLAAAAAQAAAASQSPPKDMVDLNRRIFVAALNKLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>P16762-2</accession>
    <name>UL26_HCMVA</name>
    <protein>
        <recommendedName>
            <fullName>Isoform 21kDa of Tegument protein UL26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">UL26</name>
    </gene>
    <organism>
        <name type="scientific">Human cytomegalovirus (strain AD169)</name>
        <name type="common">HHV-5</name>
        <name type="synonym">Human herpesvirus 5</name>
        <dbReference type="NCBI Taxonomy" id="10360"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Cytomegalovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="Curr. Top. Microbiol. Immunol." volume="154" first="125" last="169">
            <title>Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Bankier A.T."/>
                <person name="Beck S."/>
                <person name="Bohni R."/>
                <person name="Brown C.M."/>
                <person name="Cerny R."/>
                <person name="Horsnell T."/>
                <person name="Hutchison C.A.III."/>
                <person name="Kouzarides T."/>
                <person name="Martignetti J.A."/>
            </authorList>
            <dbReference type="PubMed" id="2161319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="J. Virol." volume="76" first="4836" last="4847">
            <title>Open reading frame UL26 of human cytomegalovirus encodes a novel tegument protein that contains a strong transcriptional activation domain.</title>
            <authorList>
                <person name="Stamminger T."/>
                <person name="Gstaiger M."/>
                <person name="Weinzierl K."/>
                <person name="Lorz K."/>
                <person name="Winkler M."/>
                <person name="Schaffner W."/>
            </authorList>
            <dbReference type="PubMed" id="11967300"/>
            <dbReference type="DOI" id="10.1128/JVI.76.10.4836-4847.2002"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ALTERNATIVE INITIATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="17" last="28">
            <title>The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.</title>
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
            <dbReference type="PubMed" id="12533697"/>
            <dbReference type="DOI" id="10.1099/vir.0.18606-0"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="1053" last="1053">
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:12533697</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="10960" last="10966">
            <title>Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome.</title>
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
            <dbReference type="PubMed" id="15452216"/>
            <dbReference type="DOI" id="10.1128/JVI.78.20.10960-10966.2004"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="13395" last="13395">
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:15452216</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative initiation"/>
        <isoform>
            <id>P16762-2</id>
            <name>21kDa</name>
            <sequence type="described" ref="VSP_036205"/>
        </isoform>
        <isoform>
            <id>P16762-1</id>
            <name>27kDa</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000008991">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008992">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <sequence length="188" mass="21155" checksum="57EA40349212FEB8" modified="2009-01-20" version="2">MTSRRAPDGGLNLDDFMRRQRGRHLDLPYPRGYTLFVCDVEETILTPRDVEYWKLLVVTQGQLRVIGTIGLANLFSWDRSVAGVAADGSVLCYEISRENFVVRAADSLPQLLERGLLHSYFEDVERAAQGRLRHGNRSGLRRDADGQVIRESACYVSRVLLRHRVTPGKQEITDAMFEAGNVPSALLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>P16766-2</accession>
    <name>UL35_HCMVA</name>
    <protein>
        <recommendedName>
            <fullName>Isoform UL35A of Protein UL35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">UL35</name>
    </gene>
    <organism>
        <name type="scientific">Human cytomegalovirus (strain AD169)</name>
        <name type="common">HHV-5</name>
        <name type="synonym">Human herpesvirus 5</name>
        <dbReference type="NCBI Taxonomy" id="10360"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Cytomegalovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="Curr. Top. Microbiol. Immunol." volume="154" first="125" last="169">
            <title>Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Bankier A.T."/>
                <person name="Beck S."/>
                <person name="Bohni R."/>
                <person name="Brown C.M."/>
                <person name="Cerny R."/>
                <person name="Horsnell T."/>
                <person name="Hutchison C.A.III."/>
                <person name="Kouzarides T."/>
                <person name="Martignetti J.A."/>
            </authorList>
            <dbReference type="PubMed" id="2161319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2002" name="J. Virol." volume="76" first="2460" last="2468">
            <title>The human cytomegalovirus UL35 gene encodes two proteins with different functions.</title>
            <authorList>
                <person name="Liu Y."/>
                <person name="Biegalke B.J."/>
            </authorList>
            <dbReference type="PubMed" id="11836424"/>
            <dbReference type="DOI" id="10.1128/jvi.76.5.2460-2468.2002"/>
        </citation>
        <scope>ISOFORM UL35A</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="17" last="28">
            <title>The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.</title>
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
            <dbReference type="PubMed" id="12533697"/>
            <dbReference type="DOI" id="10.1099/vir.0.18606-0"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="1053" last="1053">
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:12533697</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="9512" last="9523">
            <title>Human cytomegalovirus tegument proteins ppUL82 (pp71) and ppUL35 interact and cooperatively activate the major immediate-early enhancer.</title>
            <authorList>
                <person name="Schierling K."/>
                <person name="Stamminger T."/>
                <person name="Mertens T."/>
                <person name="Winkler M."/>
            </authorList>
            <dbReference type="PubMed" id="15308743"/>
            <dbReference type="DOI" id="10.1128/JVI.78.17.9512-9523.2004"/>
        </citation>
        <scope>INTERACTION WITH UL82</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="10960" last="10966">
            <title>Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome.</title>
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
            <dbReference type="PubMed" id="15452216"/>
            <dbReference type="DOI" id="10.1128/JVI.78.20.10960-10966.2004"/>
        </citation>
        <scope>IDENTIFICATION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="13395" last="13395">
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:15452216</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2005" name="J. Virol." volume="79" first="3084" last="3096">
            <title>Human cytomegalovirus tegument protein ppUL35 is important for viral replication and particle formation.</title>
            <authorList>
                <person name="Schierling K."/>
                <person name="Buser C."/>
                <person name="Mertens T."/>
                <person name="Winkler M."/>
            </authorList>
            <dbReference type="PubMed" id="15709028"/>
            <dbReference type="DOI" id="10.1128/JVI.79.5.3084-3096.2005"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2011" name="Virology" volume="414" first="119" last="129">
            <title>Nuclear body formation and PML body remodeling by the human cytomegalovirus protein UL35.</title>
            <authorList>
                <person name="Salsman J."/>
                <person name="Wang X."/>
                <person name="Frappier L."/>
            </authorList>
            <dbReference type="PubMed" id="21489587"/>
            <dbReference type="DOI" id="10.1016/j.virol.2011.03.013"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2012" name="J. Virol." volume="86" first="806" last="820">
            <title>Proteomic profiling of the human cytomegalovirus UL35 gene products reveals a role for UL35 in the DNA repair response.</title>
            <authorList>
                <person name="Salsman J."/>
                <person name="Jagannathan M."/>
                <person name="Paladino P."/>
                <person name="Chan P.K."/>
                <person name="Dellaire G."/>
                <person name="Raught B."/>
                <person name="Frappier L."/>
            </authorList>
            <dbReference type="PubMed" id="22072767"/>
            <dbReference type="DOI" id="10.1128/jvi.05442-11"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HOST UBP7 AND DCAF1 (ISOFORM UL35)</scope>
        <scope>INTERACTION WITH HOST UBP7 (ISOFORM UL35A)</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2018" name="J. Virol." volume="92" first="0" last="0">
            <title>Interaction of Human Cytomegalovirus Tegument Proteins ppUL35 and ppUL35A with Sorting Nexin 5 Regulates Glycoprotein B (gpUL55) Localization.</title>
            <authorList>
                <person name="Maschkowitz G."/>
                <person name="Gaertner S."/>
                <person name="Hofmann-Winkler H."/>
                <person name="Fickenscher H."/>
                <person name="Winkler M."/>
            </authorList>
            <dbReference type="PubMed" id="29444945"/>
            <dbReference type="DOI" id="10.1128/jvi.00013-18"/>
        </citation>
        <scope>FUNCTION (ISOFORM UL35)</scope>
        <scope>FUNCTION (ISOFORM UL35A)</scope>
        <scope>INTERACTION WITH HOST SNX5 (ISOFORM UL35)</scope>
        <scope>INTERACTION WITH HOST SNX5 (ISOFORM UL35A)</scope>
    </reference>
    <reference key="12">
        <citation type="journal article" date="2020" name="Microorganisms" volume="8" first="0" last="0">
            <title>The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription.</title>
            <authorList>
                <person name="Fabits M."/>
                <person name="Goncalves Magalhaes V."/>
                <person name="Chan B."/>
                <person name="Girault V."/>
                <person name="Elbasani E."/>
                <person name="Rossetti E."/>
                <person name="Saeland E."/>
                <person name="Messerle M."/>
                <person name="Pichlmair A."/>
                <person name="Lisnic V.J."/>
                <person name="Brinkmann M.M."/>
            </authorList>
            <dbReference type="PubMed" id="32466380"/>
            <dbReference type="DOI" id="10.3390/microorganisms8060790"/>
        </citation>
        <scope>FUNCTION (ISOFORM UL35)</scope>
        <scope>INTERACTION WITH HOST TBK1 (ISOFORM UL35)</scope>
        <scope>SUBCELLULAR LOCATION (ISOFORM UL35)</scope>
    </reference>
    <comment type="function">
        <text evidence="3 5">Promotes cytoplasmic UL82 accumulation and inhibits UL35-containing nuclear bodies formation (PubMed:21489587). Regulates viral assembly by controlling the localization of the essential gB through regulation of a retrograde transport pathway. This modulation occurs via binding and inhibition of host sorting nexin 5/SNX5 (PubMed:29444945).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 4 5">Interacts with UL82. Interacts with isoform UL35. Interacts with host UBP7; this interaction significantly inhibits the ability of USP7 to form nuclear bodies (PubMed:22072767). Interacts with host SNX5; this interaction allows proper gB localization during viral assembly (PubMed:29444945).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative initiation"/>
        <isoform>
            <id>P16766-1</id>
            <name>UL35</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P16766-2</id>
            <name>UL35A</name>
            <sequence type="described" ref="VSP_044013"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000008991">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008992">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="11836424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15308743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="21489587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="22072767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="5">
        <source>
            <dbReference type="PubMed" id="29444945"/>
        </source>
    </evidence>
    <sequence length="193" mass="20898" checksum="2D5D47BA7E80B033" modified="1990-08-01" version="1">MMIEGASRQTGLTPKRFMELLDRAPLGQESEPEITEHRDLFADVFRRPVTDAASSSSASSSSSSASPNSVSLPSARSSSTRTTTPASTYTSAGTSSTTGLLLSSSLSGSHGISSADLEQPPRQRRRMVSVTLFSPYSVAYSHHRRHRRRRSPPPAPRGPAHTRFQGPDSMPSTSYGSDVEDPRDDLAENLRHL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2022-02-23" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>P16770-2</accession>
    <name>UL117_HCMVA</name>
    <protein>
        <recommendedName>
            <fullName>Isoform UL117.5 of Protein UL117</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">UL117</name>
    </gene>
    <organism>
        <name type="scientific">Human cytomegalovirus (strain AD169)</name>
        <name type="common">HHV-5</name>
        <name type="synonym">Human herpesvirus 5</name>
        <dbReference type="NCBI Taxonomy" id="10360"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Cytomegalovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1990" name="Curr. Top. Microbiol. Immunol." volume="154" first="125" last="169">
            <title>Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Bankier A.T."/>
                <person name="Beck S."/>
                <person name="Bohni R."/>
                <person name="Brown C.M."/>
                <person name="Cerny R."/>
                <person name="Horsnell T."/>
                <person name="Hutchison C.A.III."/>
                <person name="Kouzarides T."/>
                <person name="Martignetti J.A."/>
            </authorList>
            <dbReference type="PubMed" id="2161319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="17" last="28">
            <title>The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.</title>
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
            <dbReference type="PubMed" id="12533697"/>
            <dbReference type="DOI" id="10.1099/vir.0.18606-0"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="1053" last="1053">
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:12533697</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2008" name="J. Virol." volume="82" first="3452" last="3465">
            <title>The full-length protein encoded by human cytomegalovirus gene UL117 is required for the proper maturation of viral replication compartments.</title>
            <authorList>
                <person name="Qian Z."/>
                <person name="Xuan B."/>
                <person name="Hong T.T."/>
                <person name="Yu D."/>
            </authorList>
            <dbReference type="PubMed" id="18216115"/>
            <dbReference type="DOI" id="10.1128/JVI.01964-07"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>ISOFORM UL117.5</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2010" name="PLoS Pathog." volume="6" first="E1000814" last="E1000814">
            <title>Human cytomegalovirus protein pUL117 targets the mini-chromosome maintenance complex and suppresses cellular DNA synthesis.</title>
            <authorList>
                <person name="Qian Z."/>
                <person name="Leung-Pineda V."/>
                <person name="Xuan B."/>
                <person name="Piwnica-Worms H."/>
                <person name="Yu D."/>
            </authorList>
            <dbReference type="PubMed" id="20333247"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1000814"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="alternative products">
        <event type="alternative initiation"/>
        <isoform>
            <id>P16770-2</id>
            <name>UL117.5</name>
            <sequence type="described" ref="VSP_044012"/>
        </isoform>
        <isoform>
            <id>P16770-1</id>
            <name>UL117</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000008991">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008992">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="18216115"/>
        </source>
    </evidence>
    <sequence length="294" mass="31068" checksum="211269D4EF3B5800" modified="1990-08-01" version="1">MDHSEFLTSFRREVDRQTVLTAESAPATAEVCLGDALPGGVMGGGGLPAGVGSASAAVAAAAAAVAGVPVAANPVMPATATVTTPPMIDLTSHHRPLTLFTPASAAAAPAVATNGGNATYILPADCRYAPLFASKYKYVFEEVSRLMRLHDSTAVQLQISASCGNAFQALKSALLKLHNVTVLAGQQLITQTMPHTPQAVATFKFFHQDPNRVLDCIRPVVPRSTSYHETGVYQMWVSGATKKDLFDAVTLCASIVEKQPDVFNINVSLLTYPSIAAPHLPLYNEFTSFRLPTS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2021-06-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>P16778-2</accession>
    <name>VGLI_HCMVA</name>
    <protein>
        <recommendedName>
            <fullName>Isoform vMIA of UL37 immediate early glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">UL37</name>
    </gene>
    <organism>
        <name type="scientific">Human cytomegalovirus (strain AD169)</name>
        <name type="common">HHV-5</name>
        <name type="synonym">Human herpesvirus 5</name>
        <dbReference type="NCBI Taxonomy" id="10360"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Cytomegalovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1988" name="Virology" volume="165" first="151" last="164">
            <title>An immediate early gene of human cytomegalovirus encodes a potential membrane glycoprotein.</title>
            <authorList>
                <person name="Kouzarides T."/>
                <person name="Bankier A.T."/>
                <person name="Satchwell S.C."/>
                <person name="Preddy E."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2838954"/>
            <dbReference type="DOI" id="10.1016/0042-6822(88)90668-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1990" name="Curr. Top. Microbiol. Immunol." volume="154" first="125" last="169">
            <title>Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Bankier A.T."/>
                <person name="Beck S."/>
                <person name="Bohni R."/>
                <person name="Brown C.M."/>
                <person name="Cerny R."/>
                <person name="Horsnell T."/>
                <person name="Hutchison C.A.III."/>
                <person name="Kouzarides T."/>
                <person name="Martignetti J.A."/>
            </authorList>
            <dbReference type="PubMed" id="2161319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ISOFORM PUL37M</scope>
        <scope>ISOFORM VMIA</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1996" name="J. Virol." volume="70" first="7198" last="7208">
            <title>The human cytomegalovirus UL37 immediate-early regulatory protein is an integral membrane N-glycoprotein which traffics through the endoplasmic reticulum and Golgi apparatus.</title>
            <authorList>
                <person name="Al-Barazi H.O."/>
                <person name="Colberg-Poley A.M."/>
            </authorList>
            <dbReference type="PubMed" id="8794367"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="17" last="28">
            <title>The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.</title>
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
            <dbReference type="PubMed" id="12533697"/>
            <dbReference type="DOI" id="10.1099/vir.0.18606-0"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="1053" last="1053">
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:12533697</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="22605" last="22614">
            <title>An anti-apoptotic viral protein that recruits Bax to mitochondria.</title>
            <authorList>
                <person name="Poncet D."/>
                <person name="Larochette N."/>
                <person name="Pauleau A.L."/>
                <person name="Boya P."/>
                <person name="Jalil A.A."/>
                <person name="Cartron P.F."/>
                <person name="Vallette F."/>
                <person name="Schnebelen C."/>
                <person name="Bartle L.M."/>
                <person name="Skaletskaya A."/>
                <person name="Boutolleau D."/>
                <person name="Martinou J.C."/>
                <person name="Goldmacher V.S."/>
                <person name="Kroemer G."/>
                <person name="Zamzami N."/>
            </authorList>
            <dbReference type="PubMed" id="15004026"/>
            <dbReference type="DOI" id="10.1074/jbc.M308408200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HOST BAX</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="J. Gen. Virol." volume="85" first="1989" last="1994">
            <title>Internal cleavage of the human cytomegalovirus UL37 immediate-early glycoprotein and divergent trafficking of its proteolytic fragments.</title>
            <authorList>
                <person name="Mavinakere M.S."/>
                <person name="Colberg-Poley A.M."/>
            </authorList>
            <dbReference type="PubMed" id="15218184"/>
            <dbReference type="DOI" id="10.1099/vir.0.80094-0"/>
        </citation>
        <scope>CLEAVAGE SITE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7988" last="7993">
            <title>Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria.</title>
            <authorList>
                <person name="Arnoult D."/>
                <person name="Bartle L.M."/>
                <person name="Skaletskaya A."/>
                <person name="Poncet D."/>
                <person name="Zamzami N."/>
                <person name="Park P.U."/>
                <person name="Sharpe J."/>
                <person name="Youle R.J."/>
                <person name="Goldmacher V.S."/>
            </authorList>
            <dbReference type="PubMed" id="15148411"/>
            <dbReference type="DOI" id="10.1073/pnas.0401897101"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2010" name="J. Virol." volume="84" first="7898" last="7903">
            <title>Trafficking of UL37 proteins into mitochondrion-associated membranes during permissive human cytomegalovirus infection.</title>
            <authorList>
                <person name="Bozidis P."/>
                <person name="Williamson C.D."/>
                <person name="Wong D.S."/>
                <person name="Colberg-Poley A.M."/>
            </authorList>
            <dbReference type="PubMed" id="20504938"/>
            <dbReference type="DOI" id="10.1128/JVI.00885-10"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Mitochondrion" volume="11" first="935" last="945">
            <title>Human cytomegalovirus infection increases mitochondrial biogenesis.</title>
            <authorList>
                <person name="Kaarbo M."/>
                <person name="Ager-Wick E."/>
                <person name="Osenbroch P.O."/>
                <person name="Kilander A."/>
                <person name="Skinnes R."/>
                <person name="Muller F."/>
                <person name="Eide L."/>
            </authorList>
            <dbReference type="PubMed" id="21907833"/>
            <dbReference type="DOI" id="10.1016/j.mito.2011.08.008"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2011" name="Science" volume="332" first="1093" last="1097">
            <title>Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity.</title>
            <authorList>
                <person name="Seo J.Y."/>
                <person name="Yaneva R."/>
                <person name="Hinson E.R."/>
                <person name="Cresswell P."/>
            </authorList>
            <dbReference type="PubMed" id="21527675"/>
            <dbReference type="DOI" id="10.1126/science.1202007"/>
        </citation>
        <scope>INTERACTION WITH HOST RSAD2</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="2">Transported from the endoplasmic reticulum (ER) through the mitochondrial associated membrane (MAMs) to the mitochondrial outer membrane. Associates with internal lipid rafts (LRs) in the MAM.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P16778-1</id>
            <name>gpUL37</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P16778-2</id>
            <name>vMIA</name>
            <sequence type="described" ref="VSP_044015 VSP_044014"/>
        </isoform>
        <isoform>
            <id>P16778-3</id>
            <name>pUL37m</name>
            <sequence type="described" ref="VSP_044016"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000008991">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008992">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15218184"/>
        </source>
    </evidence>
    <sequence length="163" mass="19115" checksum="B657342BB57AEC21" modified="2000-05-30" version="2" precursor="true">MSPVYVNLLGSVGLLAFWYFSYRWIQRKRLEDPLPPWLRKKKACALTRRSRHRLRRQHGVIDGENSETERSVDLVAALLAEAGEESVTEDTEREDTEEEREDEEEENEARTPEVNPIDAEGLSGLAREACEALKKALRRHRFLWQRRQRARMLQHNGPQQSHQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2021-06-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>P16778-3</accession>
    <name>VGLI_HCMVA</name>
    <protein>
        <recommendedName>
            <fullName>Isoform pUL37m of UL37 immediate early glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">UL37</name>
    </gene>
    <organism>
        <name type="scientific">Human cytomegalovirus (strain AD169)</name>
        <name type="common">HHV-5</name>
        <name type="synonym">Human herpesvirus 5</name>
        <dbReference type="NCBI Taxonomy" id="10360"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Cytomegalovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1988" name="Virology" volume="165" first="151" last="164">
            <title>An immediate early gene of human cytomegalovirus encodes a potential membrane glycoprotein.</title>
            <authorList>
                <person name="Kouzarides T."/>
                <person name="Bankier A.T."/>
                <person name="Satchwell S.C."/>
                <person name="Preddy E."/>
                <person name="Barrell B.G."/>
            </authorList>
            <dbReference type="PubMed" id="2838954"/>
            <dbReference type="DOI" id="10.1016/0042-6822(88)90668-X"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1990" name="Curr. Top. Microbiol. Immunol." volume="154" first="125" last="169">
            <title>Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Bankier A.T."/>
                <person name="Beck S."/>
                <person name="Bohni R."/>
                <person name="Brown C.M."/>
                <person name="Cerny R."/>
                <person name="Horsnell T."/>
                <person name="Hutchison C.A.III."/>
                <person name="Kouzarides T."/>
                <person name="Martignetti J.A."/>
            </authorList>
            <dbReference type="PubMed" id="2161319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <scope>ISOFORM PUL37M</scope>
        <scope>ISOFORM VMIA</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1996" name="J. Virol." volume="70" first="7198" last="7208">
            <title>The human cytomegalovirus UL37 immediate-early regulatory protein is an integral membrane N-glycoprotein which traffics through the endoplasmic reticulum and Golgi apparatus.</title>
            <authorList>
                <person name="Al-Barazi H.O."/>
                <person name="Colberg-Poley A.M."/>
            </authorList>
            <dbReference type="PubMed" id="8794367"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="17" last="28">
            <title>The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.</title>
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
            <dbReference type="PubMed" id="12533697"/>
            <dbReference type="DOI" id="10.1099/vir.0.18606-0"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="1053" last="1053">
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:12533697</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2004" name="J. Biol. Chem." volume="279" first="22605" last="22614">
            <title>An anti-apoptotic viral protein that recruits Bax to mitochondria.</title>
            <authorList>
                <person name="Poncet D."/>
                <person name="Larochette N."/>
                <person name="Pauleau A.L."/>
                <person name="Boya P."/>
                <person name="Jalil A.A."/>
                <person name="Cartron P.F."/>
                <person name="Vallette F."/>
                <person name="Schnebelen C."/>
                <person name="Bartle L.M."/>
                <person name="Skaletskaya A."/>
                <person name="Boutolleau D."/>
                <person name="Martinou J.C."/>
                <person name="Goldmacher V.S."/>
                <person name="Kroemer G."/>
                <person name="Zamzami N."/>
            </authorList>
            <dbReference type="PubMed" id="15004026"/>
            <dbReference type="DOI" id="10.1074/jbc.M308408200"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HOST BAX</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="J. Gen. Virol." volume="85" first="1989" last="1994">
            <title>Internal cleavage of the human cytomegalovirus UL37 immediate-early glycoprotein and divergent trafficking of its proteolytic fragments.</title>
            <authorList>
                <person name="Mavinakere M.S."/>
                <person name="Colberg-Poley A.M."/>
            </authorList>
            <dbReference type="PubMed" id="15218184"/>
            <dbReference type="DOI" id="10.1099/vir.0.80094-0"/>
        </citation>
        <scope>CLEAVAGE SITE</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2004" name="Proc. Natl. Acad. Sci. U.S.A." volume="101" first="7988" last="7993">
            <title>Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria.</title>
            <authorList>
                <person name="Arnoult D."/>
                <person name="Bartle L.M."/>
                <person name="Skaletskaya A."/>
                <person name="Poncet D."/>
                <person name="Zamzami N."/>
                <person name="Park P.U."/>
                <person name="Sharpe J."/>
                <person name="Youle R.J."/>
                <person name="Goldmacher V.S."/>
            </authorList>
            <dbReference type="PubMed" id="15148411"/>
            <dbReference type="DOI" id="10.1073/pnas.0401897101"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2010" name="J. Virol." volume="84" first="7898" last="7903">
            <title>Trafficking of UL37 proteins into mitochondrion-associated membranes during permissive human cytomegalovirus infection.</title>
            <authorList>
                <person name="Bozidis P."/>
                <person name="Williamson C.D."/>
                <person name="Wong D.S."/>
                <person name="Colberg-Poley A.M."/>
            </authorList>
            <dbReference type="PubMed" id="20504938"/>
            <dbReference type="DOI" id="10.1128/JVI.00885-10"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2011" name="Mitochondrion" volume="11" first="935" last="945">
            <title>Human cytomegalovirus infection increases mitochondrial biogenesis.</title>
            <authorList>
                <person name="Kaarbo M."/>
                <person name="Ager-Wick E."/>
                <person name="Osenbroch P.O."/>
                <person name="Kilander A."/>
                <person name="Skinnes R."/>
                <person name="Muller F."/>
                <person name="Eide L."/>
            </authorList>
            <dbReference type="PubMed" id="21907833"/>
            <dbReference type="DOI" id="10.1016/j.mito.2011.08.008"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2011" name="Science" volume="332" first="1093" last="1097">
            <title>Human cytomegalovirus directly induces the antiviral protein viperin to enhance infectivity.</title>
            <authorList>
                <person name="Seo J.Y."/>
                <person name="Yaneva R."/>
                <person name="Hinson E.R."/>
                <person name="Cresswell P."/>
            </authorList>
            <dbReference type="PubMed" id="21527675"/>
            <dbReference type="DOI" id="10.1126/science.1202007"/>
        </citation>
        <scope>INTERACTION WITH HOST RSAD2</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="2">Not cleaved or N-glycosylated.</text>
    </comment>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P16778-2</id>
            <name>vMIA</name>
            <sequence type="described" ref="VSP_044015 VSP_044014"/>
        </isoform>
        <isoform>
            <id>P16778-1</id>
            <name>gpUL37</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P16778-3</id>
            <name>pUL37m</name>
            <sequence type="described" ref="VSP_044016"/>
        </isoform>
    </comment>
    <dbReference type="Proteomes" id="UP000008991">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008992">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="15218184"/>
        </source>
    </evidence>
    <sequence length="402" mass="46435" checksum="BDFD81E69DC4753E" modified="2000-05-30" version="2" precursor="true">MSPVYVNLLGSVGLLAFWYFSYRWIQRKRLEDPLPPWLRKKKACALTRRSRHRLRRQHGVIDGENSETERSVDLVAALLAEAGEESVTEDTEREDTEEEREDEEEENEARTPEVNPIDAEGLSGLAREACEALKKALRRHRFLWQRRQRARMLQHNGPQQSHHAAVFCRVHGLRGFQYHLEGWFPLRVLNESREINVTEVHGEVACFRNDTNVTVGQLTLNFTGHSYVLRAIAHTSPFESYVRWEETNVTDNATSSENTTTVMSTLTKYAESDYIFLQDMCPRFLKRTVKLTRNKTKHNVTVTGNNMTTLPVWTPECKGWTYWTTLSVMWRNRRSALLRAKSRALGHWALLSICTVAAGSIALLSLFCILLIGLRRDLLEDFRYICRDEGSSSTKNDVHRIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>P17151-2</accession>
    <name>EP84_HCMVA</name>
    <protein>
        <recommendedName>
            <fullName>Isoform p50 of Early phosphoprotein p84</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName>p20</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>p26</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>p28</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name type="primary">UL112/UL113</name>
    </gene>
    <organism>
        <name type="scientific">Human cytomegalovirus (strain AD169)</name>
        <name type="common">HHV-5</name>
        <name type="synonym">Human herpesvirus 5</name>
        <dbReference type="NCBI Taxonomy" id="10360"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Cytomegalovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1988" name="J. Virol." volume="62" first="331" last="340">
            <title>Four phosphoproteins with common amino termini are encoded by human cytomegalovirus AD169.</title>
            <authorList>
                <person name="Wright D.A."/>
                <person name="Staprans S.I."/>
                <person name="Spector D.H."/>
            </authorList>
            <dbReference type="PubMed" id="2824853"/>
        </citation>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1989" name="J. Virol." volume="63" first="3117" last="3127">
            <title>Posttranscriptional regulation of a class of human cytomegalovirus phosphoproteins encoded by an early transcription unit.</title>
            <authorList>
                <person name="Wright D.A."/>
                <person name="Spector D.H."/>
            </authorList>
            <dbReference type="PubMed" id="2542619"/>
        </citation>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1990" name="Curr. Top. Microbiol. Immunol." volume="154" first="125" last="169">
            <title>Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Bankier A.T."/>
                <person name="Beck S."/>
                <person name="Bohni R."/>
                <person name="Brown C.M."/>
                <person name="Cerny R."/>
                <person name="Horsnell T."/>
                <person name="Hutchison C.A.III."/>
                <person name="Kouzarides T."/>
                <person name="Martignetti J.A."/>
            </authorList>
            <dbReference type="PubMed" id="2161319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM P84)</scope>
    </reference>
    <reference key="4">
        <citation type="submission" date="1997-05" db="EMBL/GenBank/DDBJ databases">
            <title>Regulation of major immediate early gene promoter by early phosphoproteins of human cytomegalovirus.</title>
            <authorList>
                <person name="Wang S.-K."/>
                <person name="Duh C.-Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P34; P43; P50 AND P84)</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="17" last="28">
            <title>The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.</title>
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
            <dbReference type="PubMed" id="12533697"/>
            <dbReference type="DOI" id="10.1099/vir.0.18606-0"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="1053" last="1053">
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:12533697</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="10960" last="10966">
            <title>Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome.</title>
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
            <dbReference type="PubMed" id="15452216"/>
            <dbReference type="DOI" id="10.1128/JVI.78.20.10960-10966.2004"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="13395" last="13395">
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:15452216</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2006" name="J. Virol." volume="80" first="2718" last="2727">
            <title>Interactions among four proteins encoded by the human cytomegalovirus UL112-113 region regulate their intranuclear targeting and the recruitment of UL44 to prereplication foci.</title>
            <authorList>
                <person name="Park M.-Y."/>
                <person name="Kim Y.-E."/>
                <person name="Seo M.-R."/>
                <person name="Lee J.-R."/>
                <person name="Lee C.H."/>
                <person name="Ahn J.-H."/>
            </authorList>
            <dbReference type="PubMed" id="16501081"/>
            <dbReference type="DOI" id="10.1128/JVI.80.6.2718-2727.2006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2009" name="J. Gen. Virol." volume="90" first="2840" last="2848">
            <title>Novel virus-associated proteins encoded by UL112-113 of human cytomegalovirus.</title>
            <authorList>
                <person name="Wang S.K."/>
                <person name="Hu C.H."/>
                <person name="Lu M.C."/>
                <person name="Duh C.Y."/>
                <person name="Liao P.C."/>
                <person name="Tyan Y.C."/>
            </authorList>
            <dbReference type="PubMed" id="19656965"/>
            <dbReference type="DOI" id="10.1099/vir.0.013037-0"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2015" name="J. Gen. Virol." volume="96" first="1115" last="1126">
            <title>Calpains mediate the proteolytic modification of human cytomegalovirus UL112-113 proteins.</title>
            <authorList>
                <person name="Wang S.K."/>
                <person name="Jiang M.J."/>
                <person name="Lin S.R."/>
                <person name="Chen M.Y."/>
                <person name="Wang H.H."/>
                <person name="Duh C.Y."/>
            </authorList>
            <dbReference type="PubMed" id="25564485"/>
            <dbReference type="DOI" id="10.1099/vir.0.000040"/>
        </citation>
        <scope>CLEAVAGE BY HOST CAPN1 AND CAPN2</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P17151-2</id>
            <name>p50</name>
            <name>50 kDa phosphoprotein</name>
            <sequence type="described" ref="VSP_034769 VSP_034772"/>
        </isoform>
        <isoform>
            <id>P17151-3</id>
            <name>p43</name>
            <name>43 kDa phosphoprotein</name>
            <sequence type="described" ref="VSP_034771 VSP_034770"/>
        </isoform>
        <isoform>
            <id>P17151-1</id>
            <name>p84</name>
            <name>84 kDa phosphoprotein</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P17151-4</id>
            <name>p34</name>
            <name>34 kDa phosphoprotein</name>
            <sequence type="described" ref="VSP_034768 VSP_034767"/>
        </isoform>
        <text>Isoforms 1, 2, 3 and 4 share a common N-terminus.</text>
    </comment>
    <dbReference type="Proteomes" id="UP000008991">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008992">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="423" mass="44045" checksum="E3D7635CE917B284" modified="2000-05-30" version="2">MDLPTTVVRKYWTFANPNRILHQSVNQTFDVRQFVFDTARLVNCVDGDGKVLHLNKGWLCATIMQHGEASAGAKTQQGFMSIDITGDGELQEHLFVRGGIVFNKSVSSVVGSSGPNESALLTMISENGNLQVTYVRHYLKNHGESSSGGGGCGAASTASAVCVSSLGGSGGTRDGPSAEEQQRRRQEQRHEERRKKSSSSAGGGGGGGAGGGGGGGGSGGQHSSDSANGLLRDPRLMNRQKERRPPPSSENDGSPPLREAKRQKTTAQHEGHGGGGKNETEQQSGGAGGGGGGGSGRMSLPLDTSEAVAFLNYSSSSSAVSSSSNNHHHHHHHHNAVTDVAAGTDDSCQRRRAGLSSSTTAASRGPPQLSPQPALAPQQPHVRHSSPPVLYPQVPSPVSRPLPPQSKHQLLLPGPCVKSSPTW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>P17151-3</accession>
    <name>EP84_HCMVA</name>
    <protein>
        <recommendedName>
            <fullName>Isoform p43 of Early phosphoprotein p84</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName>p20</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>p26</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>p28</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name type="primary">UL112/UL113</name>
    </gene>
    <organism>
        <name type="scientific">Human cytomegalovirus (strain AD169)</name>
        <name type="common">HHV-5</name>
        <name type="synonym">Human herpesvirus 5</name>
        <dbReference type="NCBI Taxonomy" id="10360"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Cytomegalovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1988" name="J. Virol." volume="62" first="331" last="340">
            <title>Four phosphoproteins with common amino termini are encoded by human cytomegalovirus AD169.</title>
            <authorList>
                <person name="Wright D.A."/>
                <person name="Staprans S.I."/>
                <person name="Spector D.H."/>
            </authorList>
            <dbReference type="PubMed" id="2824853"/>
        </citation>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1989" name="J. Virol." volume="63" first="3117" last="3127">
            <title>Posttranscriptional regulation of a class of human cytomegalovirus phosphoproteins encoded by an early transcription unit.</title>
            <authorList>
                <person name="Wright D.A."/>
                <person name="Spector D.H."/>
            </authorList>
            <dbReference type="PubMed" id="2542619"/>
        </citation>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1990" name="Curr. Top. Microbiol. Immunol." volume="154" first="125" last="169">
            <title>Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Bankier A.T."/>
                <person name="Beck S."/>
                <person name="Bohni R."/>
                <person name="Brown C.M."/>
                <person name="Cerny R."/>
                <person name="Horsnell T."/>
                <person name="Hutchison C.A.III."/>
                <person name="Kouzarides T."/>
                <person name="Martignetti J.A."/>
            </authorList>
            <dbReference type="PubMed" id="2161319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM P84)</scope>
    </reference>
    <reference key="4">
        <citation type="submission" date="1997-05" db="EMBL/GenBank/DDBJ databases">
            <title>Regulation of major immediate early gene promoter by early phosphoproteins of human cytomegalovirus.</title>
            <authorList>
                <person name="Wang S.-K."/>
                <person name="Duh C.-Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P34; P43; P50 AND P84)</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="17" last="28">
            <title>The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.</title>
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
            <dbReference type="PubMed" id="12533697"/>
            <dbReference type="DOI" id="10.1099/vir.0.18606-0"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="1053" last="1053">
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:12533697</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="10960" last="10966">
            <title>Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome.</title>
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
            <dbReference type="PubMed" id="15452216"/>
            <dbReference type="DOI" id="10.1128/JVI.78.20.10960-10966.2004"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="13395" last="13395">
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:15452216</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2006" name="J. Virol." volume="80" first="2718" last="2727">
            <title>Interactions among four proteins encoded by the human cytomegalovirus UL112-113 region regulate their intranuclear targeting and the recruitment of UL44 to prereplication foci.</title>
            <authorList>
                <person name="Park M.-Y."/>
                <person name="Kim Y.-E."/>
                <person name="Seo M.-R."/>
                <person name="Lee J.-R."/>
                <person name="Lee C.H."/>
                <person name="Ahn J.-H."/>
            </authorList>
            <dbReference type="PubMed" id="16501081"/>
            <dbReference type="DOI" id="10.1128/JVI.80.6.2718-2727.2006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2009" name="J. Gen. Virol." volume="90" first="2840" last="2848">
            <title>Novel virus-associated proteins encoded by UL112-113 of human cytomegalovirus.</title>
            <authorList>
                <person name="Wang S.K."/>
                <person name="Hu C.H."/>
                <person name="Lu M.C."/>
                <person name="Duh C.Y."/>
                <person name="Liao P.C."/>
                <person name="Tyan Y.C."/>
            </authorList>
            <dbReference type="PubMed" id="19656965"/>
            <dbReference type="DOI" id="10.1099/vir.0.013037-0"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2015" name="J. Gen. Virol." volume="96" first="1115" last="1126">
            <title>Calpains mediate the proteolytic modification of human cytomegalovirus UL112-113 proteins.</title>
            <authorList>
                <person name="Wang S.K."/>
                <person name="Jiang M.J."/>
                <person name="Lin S.R."/>
                <person name="Chen M.Y."/>
                <person name="Wang H.H."/>
                <person name="Duh C.Y."/>
            </authorList>
            <dbReference type="PubMed" id="25564485"/>
            <dbReference type="DOI" id="10.1099/vir.0.000040"/>
        </citation>
        <scope>CLEAVAGE BY HOST CAPN1 AND CAPN2</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P17151-2</id>
            <name>p50</name>
            <name>50 kDa phosphoprotein</name>
            <sequence type="described" ref="VSP_034769 VSP_034772"/>
        </isoform>
        <isoform>
            <id>P17151-3</id>
            <name>p43</name>
            <name>43 kDa phosphoprotein</name>
            <sequence type="described" ref="VSP_034771 VSP_034770"/>
        </isoform>
        <isoform>
            <id>P17151-4</id>
            <name>p34</name>
            <name>34 kDa phosphoprotein</name>
            <sequence type="described" ref="VSP_034768 VSP_034767"/>
        </isoform>
        <isoform>
            <id>P17151-1</id>
            <name>p84</name>
            <name>84 kDa phosphoprotein</name>
            <sequence type="displayed"/>
        </isoform>
        <text>Isoforms 1, 2, 3 and 4 share a common N-terminus.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Most abundant product which level of expression remains constant throughout infection.</text>
    </comment>
    <dbReference type="Proteomes" id="UP000008991">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008992">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="358" mass="36951" checksum="269BE524C6E85CE9" modified="2000-05-30" version="2">MDLPTTVVRKYWTFANPNRILHQSVNQTFDVRQFVFDTARLVNCVDGDGKVLHLNKGWLCATIMQHGEASAGAKTQQGFMSIDITGDGELQEHLFVRGGIVFNKSVSSVVGSSGPNESALLTMISENGNLQVTYVRHYLKNHGESSSGGGGCGAASTASAVCVSSLGGSGGTRDGPSAEEQQRRRQEQRHEERRKKSSSSAGGGGGGGAGGGGGGGGSGGQHSSDSANGLLRDPRLMNRQKERRPPPSSENDGSPPLREAKRQKTTAQHEGHGGGGKNETEQQSGGAGGGGGGGSGRMSLPLDTSEAVAFLNYSSSSSAVSSSSNNHHHHHHHHNAVTDVAAGTDGIRGASASSQSAF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="1990-08-01" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>P17151-4</accession>
    <name>EP84_HCMVA</name>
    <protein>
        <recommendedName>
            <fullName>Isoform p34 of Early phosphoprotein p84</fullName>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName>p20</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>p26</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName>p28</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name type="primary">UL112/UL113</name>
    </gene>
    <organism>
        <name type="scientific">Human cytomegalovirus (strain AD169)</name>
        <name type="common">HHV-5</name>
        <name type="synonym">Human herpesvirus 5</name>
        <dbReference type="NCBI Taxonomy" id="10360"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Duplodnaviria</taxon>
            <taxon>Heunggongvirae</taxon>
            <taxon>Peploviricota</taxon>
            <taxon>Herviviricetes</taxon>
            <taxon>Herpesvirales</taxon>
            <taxon>Herpesviridae</taxon>
            <taxon>Betaherpesvirinae</taxon>
            <taxon>Cytomegalovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1988" name="J. Virol." volume="62" first="331" last="340">
            <title>Four phosphoproteins with common amino termini are encoded by human cytomegalovirus AD169.</title>
            <authorList>
                <person name="Wright D.A."/>
                <person name="Staprans S.I."/>
                <person name="Spector D.H."/>
            </authorList>
            <dbReference type="PubMed" id="2824853"/>
        </citation>
        <scope>ALTERNATIVE SPLICING</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>PHOSPHORYLATION</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1989" name="J. Virol." volume="63" first="3117" last="3127">
            <title>Posttranscriptional regulation of a class of human cytomegalovirus phosphoproteins encoded by an early transcription unit.</title>
            <authorList>
                <person name="Wright D.A."/>
                <person name="Spector D.H."/>
            </authorList>
            <dbReference type="PubMed" id="2542619"/>
        </citation>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1990" name="Curr. Top. Microbiol. Immunol." volume="154" first="125" last="169">
            <title>Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169.</title>
            <authorList>
                <person name="Chee M.S."/>
                <person name="Bankier A.T."/>
                <person name="Beck S."/>
                <person name="Bohni R."/>
                <person name="Brown C.M."/>
                <person name="Cerny R."/>
                <person name="Horsnell T."/>
                <person name="Hutchison C.A.III."/>
                <person name="Kouzarides T."/>
                <person name="Martignetti J.A."/>
            </authorList>
            <dbReference type="PubMed" id="2161319"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM P84)</scope>
    </reference>
    <reference key="4">
        <citation type="submission" date="1997-05" db="EMBL/GenBank/DDBJ databases">
            <title>Regulation of major immediate early gene promoter by early phosphoproteins of human cytomegalovirus.</title>
            <authorList>
                <person name="Wang S.-K."/>
                <person name="Duh C.-Y."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS P34; P43; P50 AND P84)</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="17" last="28">
            <title>The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome.</title>
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
            <dbReference type="PubMed" id="12533697"/>
            <dbReference type="DOI" id="10.1099/vir.0.18606-0"/>
        </citation>
        <scope>GENOME REANNOTATION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2003" name="J. Gen. Virol." volume="84" first="1053" last="1053">
            <authorList>
                <person name="Davison A.J."/>
                <person name="Dolan A."/>
                <person name="Akter P."/>
                <person name="Addison C."/>
                <person name="Dargan D.J."/>
                <person name="Alcendor D.J."/>
                <person name="McGeoch D.J."/>
                <person name="Hayward G.S."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:12533697</scope>
    </reference>
    <reference key="7">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="10960" last="10966">
            <title>Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome.</title>
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
            <dbReference type="PubMed" id="15452216"/>
            <dbReference type="DOI" id="10.1128/JVI.78.20.10960-10966.2004"/>
        </citation>
        <scope>IDENTIFICATION</scope>
    </reference>
    <reference key="8">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="13395" last="13395">
            <authorList>
                <person name="Varnum S.M."/>
                <person name="Streblow D.N."/>
                <person name="Monroe M.E."/>
                <person name="Smith P."/>
                <person name="Auberry K.J."/>
                <person name="Pasa-Tolic L."/>
                <person name="Wang D."/>
                <person name="Camp D.G. II"/>
                <person name="Rodland K."/>
                <person name="Wiley S."/>
                <person name="Britt W."/>
                <person name="Shenk T."/>
                <person name="Smith R.D."/>
                <person name="Nelson J.A."/>
            </authorList>
        </citation>
        <scope>ERRATUM OF PUBMED:15452216</scope>
    </reference>
    <reference key="9">
        <citation type="journal article" date="2006" name="J. Virol." volume="80" first="2718" last="2727">
            <title>Interactions among four proteins encoded by the human cytomegalovirus UL112-113 region regulate their intranuclear targeting and the recruitment of UL44 to prereplication foci.</title>
            <authorList>
                <person name="Park M.-Y."/>
                <person name="Kim Y.-E."/>
                <person name="Seo M.-R."/>
                <person name="Lee J.-R."/>
                <person name="Lee C.H."/>
                <person name="Ahn J.-H."/>
            </authorList>
            <dbReference type="PubMed" id="16501081"/>
            <dbReference type="DOI" id="10.1128/JVI.80.6.2718-2727.2006"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="10">
        <citation type="journal article" date="2009" name="J. Gen. Virol." volume="90" first="2840" last="2848">
            <title>Novel virus-associated proteins encoded by UL112-113 of human cytomegalovirus.</title>
            <authorList>
                <person name="Wang S.K."/>
                <person name="Hu C.H."/>
                <person name="Lu M.C."/>
                <person name="Duh C.Y."/>
                <person name="Liao P.C."/>
                <person name="Tyan Y.C."/>
            </authorList>
            <dbReference type="PubMed" id="19656965"/>
            <dbReference type="DOI" id="10.1099/vir.0.013037-0"/>
        </citation>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="11">
        <citation type="journal article" date="2015" name="J. Gen. Virol." volume="96" first="1115" last="1126">
            <title>Calpains mediate the proteolytic modification of human cytomegalovirus UL112-113 proteins.</title>
            <authorList>
                <person name="Wang S.K."/>
                <person name="Jiang M.J."/>
                <person name="Lin S.R."/>
                <person name="Chen M.Y."/>
                <person name="Wang H.H."/>
                <person name="Duh C.Y."/>
            </authorList>
            <dbReference type="PubMed" id="25564485"/>
            <dbReference type="DOI" id="10.1099/vir.0.000040"/>
        </citation>
        <scope>CLEAVAGE BY HOST CAPN1 AND CAPN2</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P17151-2</id>
            <name>p50</name>
            <name>50 kDa phosphoprotein</name>
            <sequence type="described" ref="VSP_034769 VSP_034772"/>
        </isoform>
        <isoform>
            <id>P17151-1</id>
            <name>p84</name>
            <name>84 kDa phosphoprotein</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P17151-3</id>
            <name>p43</name>
            <name>43 kDa phosphoprotein</name>
            <sequence type="described" ref="VSP_034770 VSP_034771"/>
        </isoform>
        <isoform>
            <id>P17151-4</id>
            <name>p34</name>
            <name>34 kDa phosphoprotein</name>
            <sequence type="described" ref="VSP_034767 VSP_034768"/>
        </isoform>
        <text>Isoforms 1, 2, 3 and 4 share a common N-terminus.</text>
    </comment>
    <dbReference type="Proteomes" id="UP000008991">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000008992">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <sequence length="268" mass="28142" checksum="BD5906F4EAB28FC9" modified="2000-05-30" version="2">MDLPTTVVRKYWTFANPNRILHQSVNQTFDVRQFVFDTARLVNCVDGDGKVLHLNKGWLCATIMQHGEASAGAKTQQGFMSIDITGDGELQEHLFVRGGIVFNKSVSSVVGSSGPNESALLTMISENGNLQVTYVRHYLKNHGESSSGGGGCGAASTASAVCVSSLGGSGGTRDGPSAEEQQRRRQEQRHEERRKKSSSSAGGGGGGGAGGGGGGGGSGGQHSSDSANGLLRDPRLMNRQKERRPPPSSENDGESRPSSRHGAFRVDS</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>