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<entry dataset="Swiss-Prot" created="1987-08-13" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>P04613-2</accession>
    <name>TAT_HV1MA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isoform Short of Protein Tat</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Transactivating regulatory protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tat</name>
    </gene>
    <organism>
        <name type="scientific">Human immunodeficiency virus type 1 group M subtype A (isolate MAL)</name>
        <name type="common">HIV-1</name>
        <dbReference type="NCBI Taxonomy" id="11697"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Pararnavirae</taxon>
            <taxon>Artverviricota</taxon>
            <taxon>Revtraviricetes</taxon>
            <taxon>Ortervirales</taxon>
            <taxon>Retroviridae</taxon>
            <taxon>Orthoretrovirinae</taxon>
            <taxon>Lentivirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1986" name="Cell" volume="46" first="63" last="74">
            <title>Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients.</title>
            <authorList>
                <person name="Alizon M."/>
                <person name="Wain-Hobson S."/>
                <person name="Montagnier L."/>
                <person name="Sonigo P."/>
            </authorList>
            <dbReference type="PubMed" id="2424612"/>
            <dbReference type="DOI" id="10.1016/0092-8674(86)90860-3"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC RNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Microbes Infect." volume="7" first="1364" last="1369">
            <title>Decoding Tat: the biology of HIV Tat posttranslational modifications.</title>
            <authorList>
                <person name="Hetzer C."/>
                <person name="Dormeyer W."/>
                <person name="Schnolzer M."/>
                <person name="Ott M."/>
            </authorList>
            <dbReference type="PubMed" id="16046164"/>
            <dbReference type="DOI" id="10.1016/j.micinf.2005.06.003"/>
        </citation>
        <scope>REVIEW</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2006" name="Front. Biosci." volume="11" first="708" last="717">
            <title>The multiple functions of HIV-1 Tat: proliferation versus apoptosis.</title>
            <authorList>
                <person name="Peruzzi F."/>
            </authorList>
            <dbReference type="PubMed" id="16146763"/>
            <dbReference type="DOI" id="10.2741/1829"/>
        </citation>
        <scope>REVIEW</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2006" name="Microbes Infect." volume="8" first="1347" last="1357">
            <title>HIV tat and neurotoxicity.</title>
            <authorList>
                <person name="King J.E."/>
                <person name="Eugenin E.A."/>
                <person name="Buckner C.M."/>
                <person name="Berman J.W."/>
            </authorList>
            <dbReference type="PubMed" id="16697675"/>
            <dbReference type="DOI" id="10.1016/j.micinf.2005.11.014"/>
        </citation>
        <scope>REVIEW</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P04613-1</id>
            <name>Long</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P04613-2</id>
            <name>Short</name>
            <sequence type="described" ref="VSP_022414"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Expressed in the late stage of the infection cycle, when unspliced viral RNAs are exported to the cytoplasm by the viral Rev protein.</text>
    </comment>
    <dbReference type="Proteomes" id="UP000007696">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_04079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="72" mass="8425" checksum="A150D8194062BC07" modified="1987-08-13" version="1">MDPVDPNLEPWNHPGSQPRTPCNKCYCKKCCYHCQMCFITKGLGISYGRKKRRQRRRPPQGNQAHQDPLPEQ</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>