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<entry dataset="Swiss-Prot" created="1987-08-13" modified="2022-02-23" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>P04605-2</accession>
    <name>TAT_HV2RO</name>
    <protein>
        <recommendedName>
            <fullName>Isoform Short of Protein Tat</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Transactivating regulatory protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">tat</name>
    </gene>
    <organism>
        <name type="scientific">Human immunodeficiency virus type 2 subtype A (isolate ROD)</name>
        <name type="common">HIV-2</name>
        <dbReference type="NCBI Taxonomy" id="11720"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Riboviria</taxon>
            <taxon>Pararnavirae</taxon>
            <taxon>Artverviricota</taxon>
            <taxon>Revtraviricetes</taxon>
            <taxon>Ortervirales</taxon>
            <taxon>Retroviridae</taxon>
            <taxon>Orthoretrovirinae</taxon>
            <taxon>Lentivirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1987" name="Nature" volume="326" first="662" last="669">
            <title>Genome organization and transactivation of the human immunodeficiency virus type 2.</title>
            <authorList>
                <person name="Guyader M."/>
                <person name="Emerman M."/>
                <person name="Sonigo P."/>
                <person name="Clavel F."/>
                <person name="Montagnier L."/>
                <person name="Alizon M."/>
            </authorList>
            <dbReference type="PubMed" id="3031510"/>
            <dbReference type="DOI" id="10.1038/326662a0"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1997" name="J. Virol." volume="71" first="8048" last="8055">
            <title>The sequence and structure of the 3' arm of the first stem-loop of the human immunodeficiency virus type 2 trans-activation responsive region mediate Tat-2 transactivation.</title>
            <authorList>
                <person name="Browning C."/>
                <person name="Hilfinger J.M."/>
                <person name="Rainier S."/>
                <person name="Lin V."/>
                <person name="Hedderwick S."/>
                <person name="Smith M."/>
                <person name="Markovitz D.M."/>
            </authorList>
            <dbReference type="PubMed" id="9311903"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1999" name="J. Virol." volume="73" first="5777" last="5786">
            <title>Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes.</title>
            <authorList>
                <person name="Bieniasz P.D."/>
                <person name="Grdina T.A."/>
                <person name="Bogerd H.P."/>
                <person name="Cullen B.R."/>
            </authorList>
            <dbReference type="PubMed" id="10364329"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>INTERACTION WITH HUMAN CCNT1 AND CCNT2</scope>
        <scope>MUTAGENESIS OF CYS-50</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2005" name="Microbes Infect." volume="7" first="1364" last="1369">
            <title>Decoding Tat: the biology of HIV Tat posttranslational modifications.</title>
            <authorList>
                <person name="Hetzer C."/>
                <person name="Dormeyer W."/>
                <person name="Schnolzer M."/>
                <person name="Ott M."/>
            </authorList>
            <dbReference type="PubMed" id="16046164"/>
            <dbReference type="DOI" id="10.1016/j.micinf.2005.06.003"/>
        </citation>
        <scope>REVIEW</scope>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P04605-2</id>
            <name>Short</name>
            <sequence type="described" ref="VSP_022444"/>
        </isoform>
        <isoform>
            <id>P04605-1</id>
            <name>Long</name>
            <sequence type="displayed"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Expressed in the late stage of the infection cycle, when unspliced viral RNAs are exported to the cytoplasm by the viral Rev protein.</text>
    </comment>
    <dbReference type="Proteomes" id="UP000007426">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000246871">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="99" mass="11433" checksum="489D8A28AC6B7005" modified="1987-08-13" version="1">METPLKAPESSLKSCNEPFSRTSEQDVATQELARQGEEILSQLYRPLETCNNSCYCKRCCYHCQMCFLNKGLGICYERKGRRRRTPKKTKTHPSPTPDK</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>