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<entry dataset="Swiss-Prot" created="1986-07-21" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>P03137-2</accession>
    <name>CAPSD_MUMIP</name>
    <protein>
        <recommendedName>
            <fullName>Isoform VP2 of Capsid protein VP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>Coat protein VP1</fullName>
        </alternativeName>
    </protein>
    <organism>
        <name type="scientific">Murine minute virus (strain MVM prototype)</name>
        <name type="common">MVM</name>
        <name type="synonym">Murine minute virus (strain MVM(p))</name>
        <dbReference type="NCBI Taxonomy" id="648235"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Quintoviricetes</taxon>
            <taxon>Piccovirales</taxon>
            <taxon>Parvoviridae</taxon>
            <taxon>Parvovirinae</taxon>
            <taxon>Protoparvovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Mus musculus</name>
        <name type="common">Mouse</name>
        <dbReference type="NCBI Taxonomy" id="10090"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1983" name="Nucleic Acids Res." volume="11" first="999" last="1018">
            <title>The complete DNA sequence of minute virus of mice, an autonomous parvovirus.</title>
            <authorList>
                <person name="Astell C.R."/>
                <person name="Thomson M."/>
                <person name="Merchlinsky M."/>
                <person name="Ward D.C."/>
            </authorList>
            <dbReference type="PubMed" id="6298737"/>
            <dbReference type="DOI" id="10.1093/nar/11.4.999"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1986" name="J. Virol." volume="60" first="1170" last="1174">
            <title>Three splicing patterns are used to excise the small intron common to all minute virus of mice RNAs.</title>
            <authorList>
                <person name="Morgan W.R."/>
                <person name="Ward D.C."/>
            </authorList>
            <dbReference type="PubMed" id="3783817"/>
        </citation>
        <scope>ALTERNATIVE SPLICING</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2005" name="Proc. Natl. Acad. Sci. U.S.A." volume="102" first="17148" last="17153">
            <title>Parvoviral virions deploy a capsid-tethered lipolytic enzyme to breach the endosomal membrane during cell entry.</title>
            <authorList>
                <person name="Farr G.A."/>
                <person name="Zhang L.G."/>
                <person name="Tattersall P."/>
            </authorList>
            <dbReference type="PubMed" id="16284249"/>
            <dbReference type="DOI" id="10.1073/pnas.0508477102"/>
        </citation>
        <scope>FUNCTION OF VP1</scope>
        <scope>PHOSPHOLIPASE A2-LIKE REGION</scope>
        <scope>NUCLEAR LOCALIZATION SIGNALS</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P03137-1</id>
            <name>VP1</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P03137-2</id>
            <name>VP2</name>
            <sequence type="described" ref="VSP_041135"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Major splicing isoform (approximately 70% of the molecules), produced by deletion of the initiating AUG for VP1 and downstream translation of VP2.</text>
    </comment>
    <dbReference type="Proteomes" id="UP000007019">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="587" mass="64534" checksum="9B8A75280D755056" modified="2011-05-31" version="3">MSDGTSQPDSGNAVHSAARVERAADGPGGSGGGGSGGGGVGVSTGSYDNQTHYRFLGDGWVEITALATRLVHLNMPKSENYCRIRVHNTTDTSVKGNMAKDDAHEQIWTPWSLVDANAWGVWLQPSDWQYICNTMSQLNLVSLDQEIFNVVLKTVTEQDLGGQAIKIYNNDLTACMMVAVDSNNILPYTPAANSMETLGFYPWKPTIASPYRYYFCVDRDLSVTYENQEGTVEHNVMGTPKGMNSQFFTIENTQQITLLRTGDEFATGTYYFDTNSVKLTHTWQTNRQLGQPPLLSTFPEADTDAGTLTAQGSRHGTTQMGVNWVSEAIRTRPAQVGFCQPHNDFEASRAGPFAAPKVPADITQGVDKEANGSVRYSYGKQHGENWASHGPAPERYTWDETSFGSGRDTKDGFIQSAPLVVPPPLNGILTNANPIGTKNDIHFSNVFNSYGPLTAFSHPSPVYPQGQIWDKELDLEHKPRLHITAPFVCKNNAPGQMLVRLGPNLTDQYDPNGATLSRIVTYGTFFWKGKLTMRAKLRANTTWNPVYQVSAEDNGNSYMSVTKWLPTATGNMQSVPLITRPVARNTY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-05-14" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>P0DJZ2-2</accession>
    <name>NS2_MUMIP</name>
    <protein>
        <recommendedName>
            <fullName>Isoform NS2P of Non-structural protein NS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NS2</name>
    </gene>
    <organism>
        <name type="scientific">Murine minute virus (strain MVM prototype)</name>
        <name type="common">MVM</name>
        <name type="synonym">Murine minute virus (strain MVM(p))</name>
        <dbReference type="NCBI Taxonomy" id="648235"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Quintoviricetes</taxon>
            <taxon>Piccovirales</taxon>
            <taxon>Parvoviridae</taxon>
            <taxon>Parvovirinae</taxon>
            <taxon>Protoparvovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Mus musculus</name>
        <name type="common">Mouse</name>
        <dbReference type="NCBI Taxonomy" id="10090"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1983" name="Nucleic Acids Res." volume="11" first="999" last="1018">
            <title>The complete DNA sequence of minute virus of mice, an autonomous parvovirus.</title>
            <authorList>
                <person name="Astell C.R."/>
                <person name="Thomson M."/>
                <person name="Merchlinsky M."/>
                <person name="Ward D.C."/>
            </authorList>
            <dbReference type="PubMed" id="6298737"/>
            <dbReference type="DOI" id="10.1093/nar/11.4.999"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="J. Virol." volume="67" first="1034" last="1043">
            <title>NS2 is required for efficient translation of viral mRNA in minute virus of mice-infected murine cells.</title>
            <authorList>
                <person name="Naeger L.K."/>
                <person name="Salome N."/>
                <person name="Pintel D.J."/>
            </authorList>
            <dbReference type="PubMed" id="8419637"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1999" name="J. Virol." volume="73" first="7769" last="7779">
            <title>Nuclear export factor CRM1 interacts with nonstructural proteins NS2 from parvovirus minute virus of mice.</title>
            <authorList>
                <person name="Bodendorf U."/>
                <person name="Cziepluch C."/>
                <person name="Jauniaux J.C."/>
                <person name="Rommelaere J."/>
                <person name="Salome N."/>
            </authorList>
            <dbReference type="PubMed" id="10438867"/>
        </citation>
        <scope>INTERACTION WITH HOST XPO1</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="J. Virol." volume="76" first="6364" last="6369">
            <title>Minute virus of mice small nonstructural protein NS2 interacts and colocalizes with the Smn protein.</title>
            <authorList>
                <person name="Young P.J."/>
                <person name="Jensen K.T."/>
                <person name="Burger L.R."/>
                <person name="Pintel D.J."/>
                <person name="Lorson C.L."/>
            </authorList>
            <dbReference type="PubMed" id="12021369"/>
            <dbReference type="DOI" id="10.1128/JVI.76.12.6364-6369.2002"/>
        </citation>
        <scope>INTERACTION WITH HOST SNRPN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2002" name="J. Virol." volume="76" first="10307" last="10319">
            <title>The NS2 proteins of parvovirus minute virus of mice are required for efficient nuclear egress of progeny virions in mouse cells.</title>
            <authorList>
                <person name="Eichwald V."/>
                <person name="Daeffler L."/>
                <person name="Klein M."/>
                <person name="Rommelaere J."/>
                <person name="Salome N."/>
            </authorList>
            <dbReference type="PubMed" id="12239307"/>
            <dbReference type="DOI" id="10.1128/JVI.76.20.10307-10319.2002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="J. Virol." volume="79" first="12375" last="12381">
            <title>Replication of minute virus of mice DNA is critically dependent on accumulated levels of NS2.</title>
            <authorList>
                <person name="Choi E.Y."/>
                <person name="Newman A.E."/>
                <person name="Burger L."/>
                <person name="Pintel D."/>
            </authorList>
            <dbReference type="PubMed" id="16160164"/>
            <dbReference type="DOI" id="10.1128/JVI.79.19.12375-12381.2005"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P0DJZ2-2</id>
            <name>NS2P</name>
            <sequence type="described" ref="VSP_054677"/>
        </isoform>
        <isoform>
            <id>P0DJZ2-1</id>
            <name>NS2Y</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P0DJZ2-3</id>
            <name>NS2L</name>
            <sequence type="described" ref="VSP_054678"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Major splicing isoform (approximately 85% of the molecules).</text>
    </comment>
    <dbReference type="Proteomes" id="UP000007019">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="188" mass="21640" checksum="4A43C8D6A2EBE2AA" modified="2014-05-14" version="1">MAGNAYSDEVLGATNWLKEKSNQEVFSFVFKNENVQLNGKDIGWNSYKKELQEDELKSLQRGAETTWDQSEDMEWETTVDEMTKKFGTLTIHDTEKYASQPELCTNSTCIGSRGPGFRALEHTKYSCCGHCRNPEHWGSWFQSLPRWSTEPNLVRDRGGFESVLRCGTVEERLQRAAELGLRPEITWF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-05-14" modified="2021-06-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>P0DJZ2-3</accession>
    <name>NS2_MUMIP</name>
    <protein>
        <recommendedName>
            <fullName>Isoform NS2L of Non-structural protein NS2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">NS2</name>
    </gene>
    <organism>
        <name type="scientific">Murine minute virus (strain MVM prototype)</name>
        <name type="common">MVM</name>
        <name type="synonym">Murine minute virus (strain MVM(p))</name>
        <dbReference type="NCBI Taxonomy" id="648235"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Quintoviricetes</taxon>
            <taxon>Piccovirales</taxon>
            <taxon>Parvoviridae</taxon>
            <taxon>Parvovirinae</taxon>
            <taxon>Protoparvovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Mus musculus</name>
        <name type="common">Mouse</name>
        <dbReference type="NCBI Taxonomy" id="10090"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="1983" name="Nucleic Acids Res." volume="11" first="999" last="1018">
            <title>The complete DNA sequence of minute virus of mice, an autonomous parvovirus.</title>
            <authorList>
                <person name="Astell C.R."/>
                <person name="Thomson M."/>
                <person name="Merchlinsky M."/>
                <person name="Ward D.C."/>
            </authorList>
            <dbReference type="PubMed" id="6298737"/>
            <dbReference type="DOI" id="10.1093/nar/11.4.999"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1993" name="J. Virol." volume="67" first="1034" last="1043">
            <title>NS2 is required for efficient translation of viral mRNA in minute virus of mice-infected murine cells.</title>
            <authorList>
                <person name="Naeger L.K."/>
                <person name="Salome N."/>
                <person name="Pintel D.J."/>
            </authorList>
            <dbReference type="PubMed" id="8419637"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="1999" name="J. Virol." volume="73" first="7769" last="7779">
            <title>Nuclear export factor CRM1 interacts with nonstructural proteins NS2 from parvovirus minute virus of mice.</title>
            <authorList>
                <person name="Bodendorf U."/>
                <person name="Cziepluch C."/>
                <person name="Jauniaux J.C."/>
                <person name="Rommelaere J."/>
                <person name="Salome N."/>
            </authorList>
            <dbReference type="PubMed" id="10438867"/>
        </citation>
        <scope>INTERACTION WITH HOST XPO1</scope>
    </reference>
    <reference key="4">
        <citation type="journal article" date="2002" name="J. Virol." volume="76" first="6364" last="6369">
            <title>Minute virus of mice small nonstructural protein NS2 interacts and colocalizes with the Smn protein.</title>
            <authorList>
                <person name="Young P.J."/>
                <person name="Jensen K.T."/>
                <person name="Burger L.R."/>
                <person name="Pintel D.J."/>
                <person name="Lorson C.L."/>
            </authorList>
            <dbReference type="PubMed" id="12021369"/>
            <dbReference type="DOI" id="10.1128/JVI.76.12.6364-6369.2002"/>
        </citation>
        <scope>INTERACTION WITH HOST SNRPN</scope>
        <scope>SUBCELLULAR LOCATION</scope>
    </reference>
    <reference key="5">
        <citation type="journal article" date="2002" name="J. Virol." volume="76" first="10307" last="10319">
            <title>The NS2 proteins of parvovirus minute virus of mice are required for efficient nuclear egress of progeny virions in mouse cells.</title>
            <authorList>
                <person name="Eichwald V."/>
                <person name="Daeffler L."/>
                <person name="Klein M."/>
                <person name="Rommelaere J."/>
                <person name="Salome N."/>
            </authorList>
            <dbReference type="PubMed" id="12239307"/>
            <dbReference type="DOI" id="10.1128/JVI.76.20.10307-10319.2002"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <reference key="6">
        <citation type="journal article" date="2005" name="J. Virol." volume="79" first="12375" last="12381">
            <title>Replication of minute virus of mice DNA is critically dependent on accumulated levels of NS2.</title>
            <authorList>
                <person name="Choi E.Y."/>
                <person name="Newman A.E."/>
                <person name="Burger L."/>
                <person name="Pintel D."/>
            </authorList>
            <dbReference type="PubMed" id="16160164"/>
            <dbReference type="DOI" id="10.1128/JVI.79.19.12375-12381.2005"/>
        </citation>
        <scope>FUNCTION</scope>
    </reference>
    <comment type="alternative products">
        <event type="alternative splicing"/>
        <isoform>
            <id>P0DJZ2-2</id>
            <name>NS2P</name>
            <sequence type="described" ref="VSP_054677"/>
        </isoform>
        <isoform>
            <id>P0DJZ2-1</id>
            <name>NS2Y</name>
            <sequence type="displayed"/>
        </isoform>
        <isoform>
            <id>P0DJZ2-3</id>
            <name>NS2L</name>
            <sequence type="described" ref="VSP_054678"/>
        </isoform>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Minor splicing isoform.</text>
    </comment>
    <dbReference type="Proteomes" id="UP000007019">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <evidence type="ECO:0000305" key="1"/>
    <sequence length="197" mass="22487" checksum="05CBF76BEACF1BCF" modified="2014-05-14" version="1">MAGNAYSDEVLGATNWLKEKSNQEVFSFVFKNENVQLNGKDIGWNSYKKELQEDELKSLQRGAETTWDQSEDMEWETTVDEMTKKFGTLTIHDTEKYASQPELCTNSTCIGSRGPGFRALEHTKYSCCGHCRNPEHWGSWFQSLPRWSTEPNLVRDRGGFESVLRCGTVEERLQRAAELGLRLGASWLQVPGTREQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>Q76W03</accession>
    <name>Q76W03_MUMIP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein VP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">VP</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Murine minute virus (strain MVM prototype)</name>
        <name type="common">MVM</name>
        <name type="synonym">Murine minute virus (strain MVM(p))</name>
        <dbReference type="NCBI Taxonomy" id="648235"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Quintoviricetes</taxon>
            <taxon>Piccovirales</taxon>
            <taxon>Parvoviridae</taxon>
            <taxon>Parvovirinae</taxon>
            <taxon>Protoparvovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Mus musculus</name>
        <name type="common">Mouse</name>
        <dbReference type="NCBI Taxonomy" id="10090"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1983" name="Nucleic Acids Res." volume="11" first="999" last="1018">
            <title>The complete DNA sequence of minute virus of mice, an autonomous parvovirus.</title>
            <authorList>
                <person name="Astell C.R."/>
                <person name="Thomson M."/>
                <person name="Merchlinsky M."/>
                <person name="Ward D.C."/>
            </authorList>
            <dbReference type="PubMed" id="6298737"/>
            <dbReference type="DOI" id="10.1093/nar/11.4.999"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MVM prototype</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="1986" name="J. Virol." volume="57" first="656" last="669">
            <title>DNA sequence of the lymphotropic variant of minute virus of mice, MVM(i), and comparison with the DNA sequence of the fibrotropic prototype strain.</title>
            <authorList>
                <person name="Astell C.R."/>
                <person name="Gardiner E.M."/>
                <person name="Tattersall P."/>
            </authorList>
            <dbReference type="PubMed" id="3502703"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MVM prototype</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="1986" name="J. Virol." volume="60" first="1170" last="1174">
            <title>Three splicing patterns are used to excise the small intron common to all minute virus of mice RNAs.</title>
            <authorList>
                <person name="Morgan W.R."/>
                <person name="Ward D.C."/>
            </authorList>
            <dbReference type="PubMed" id="3783817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MVM prototype</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="J02275">
        <property type="protein sequence ID" value="AAA67113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_041247.1">
        <property type="nucleotide sequence ID" value="NC_001510.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1489591"/>
    <dbReference type="Proteomes" id="UP000007019">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAA67113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007019"/>
        </source>
    </evidence>
    <sequence length="14" mass="1927" checksum="12535381FB864D1B" modified="2011-07-27" version="1">MFNYLFYRPEITWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2011-07-27" modified="2020-08-12" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>Q76W04</accession>
    <name>Q76W04_MUMIP</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein VP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">VP</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Murine minute virus (strain MVM prototype)</name>
        <name type="common">MVM</name>
        <name type="synonym">Murine minute virus (strain MVM(p))</name>
        <dbReference type="NCBI Taxonomy" id="648235"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Quintoviricetes</taxon>
            <taxon>Piccovirales</taxon>
            <taxon>Parvoviridae</taxon>
            <taxon>Parvovirinae</taxon>
            <taxon>Protoparvovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Mus musculus</name>
        <name type="common">Mouse</name>
        <dbReference type="NCBI Taxonomy" id="10090"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="1983" name="Nucleic Acids Res." volume="11" first="999" last="1018">
            <title>The complete DNA sequence of minute virus of mice, an autonomous parvovirus.</title>
            <authorList>
                <person name="Astell C.R."/>
                <person name="Thomson M."/>
                <person name="Merchlinsky M."/>
                <person name="Ward D.C."/>
            </authorList>
            <dbReference type="PubMed" id="6298737"/>
            <dbReference type="DOI" id="10.1093/nar/11.4.999"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MVM prototype</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="1986" name="J. Virol." volume="57" first="656" last="669">
            <title>DNA sequence of the lymphotropic variant of minute virus of mice, MVM(i), and comparison with the DNA sequence of the fibrotropic prototype strain.</title>
            <authorList>
                <person name="Astell C.R."/>
                <person name="Gardiner E.M."/>
                <person name="Tattersall P."/>
            </authorList>
            <dbReference type="PubMed" id="3502703"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MVM prototype</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="3">
        <citation type="journal article" date="1986" name="J. Virol." volume="60" first="1170" last="1174">
            <title>Three splicing patterns are used to excise the small intron common to all minute virus of mice RNAs.</title>
            <authorList>
                <person name="Morgan W.R."/>
                <person name="Ward D.C."/>
            </authorList>
            <dbReference type="PubMed" id="3783817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">MVM prototype</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="J02275">
        <property type="protein sequence ID" value="AAA67112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_041246.1">
        <property type="nucleotide sequence ID" value="NC_001510.1"/>
    </dbReference>
    <dbReference type="GeneID" id="1489591"/>
    <dbReference type="Proteomes" id="UP000007019">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAA67112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007019"/>
        </source>
    </evidence>
    <sequence length="9" mass="1061" checksum="C3FD405863637862" modified="2011-07-27" version="1">MVGWWGINV</sequence>
</entry>
<entry dataset="TrEMBL" created="1996-11-01" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q84365</accession>
    <name>Q84365_MUMIP</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Initiator protein NS1</fullName>
            <ecNumber evidence="6">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="28">NCVP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="26">Non-capsid protein NS-1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="27">Non-structural protein NS1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="primary">NS1</name>
    </gene>
    <organism evidence="32">
        <name type="scientific">Murine minute virus (strain MVM prototype)</name>
        <name type="common">MVM</name>
        <name type="synonym">Murine minute virus (strain MVM(p))</name>
        <dbReference type="NCBI Taxonomy" id="648235"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Monodnaviria</taxon>
            <taxon>Shotokuvirae</taxon>
            <taxon>Cossaviricota</taxon>
            <taxon>Quintoviricetes</taxon>
            <taxon>Piccovirales</taxon>
            <taxon>Parvoviridae</taxon>
            <taxon>Parvovirinae</taxon>
            <taxon>Protoparvovirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Mus musculus</name>
        <name type="common">Mouse</name>
        <dbReference type="NCBI Taxonomy" id="10090"/>
    </organismHost>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="1983" name="Nucleic Acids Res." volume="11" first="999" last="1018">
            <title>The complete DNA sequence of minute virus of mice, an autonomous parvovirus.</title>
            <authorList>
                <person name="Astell C.R."/>
                <person name="Thomson M."/>
                <person name="Merchlinsky M."/>
                <person name="Ward D.C."/>
            </authorList>
            <dbReference type="PubMed" id="6298737"/>
            <dbReference type="DOI" id="10.1093/nar/11.4.999"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">MVM prototype</strain>
        </source>
    </reference>
    <reference evidence="31 32" key="2">
        <citation type="journal article" date="1986" name="J. Virol." volume="57" first="656" last="669">
            <title>DNA sequence of the lymphotropic variant of minute virus of mice, MVM(i), and comparison with the DNA sequence of the fibrotropic prototype strain.</title>
            <authorList>
                <person name="Astell C.R."/>
                <person name="Gardiner E.M."/>
                <person name="Tattersall P."/>
            </authorList>
            <dbReference type="PubMed" id="3502703"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">MVM prototype</strain>
        </source>
    </reference>
    <reference evidence="31 32" key="3">
        <citation type="journal article" date="1986" name="J. Virol." volume="60" first="1170" last="1174">
            <title>Three splicing patterns are used to excise the small intron common to all minute virus of mice RNAs.</title>
            <authorList>
                <person name="Morgan W.R."/>
                <person name="Ward D.C."/>
            </authorList>
            <dbReference type="PubMed" id="3783817"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32">MVM prototype</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the parvoviruses initiator protein NS1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="6"/>
    <dbReference type="EMBL" id="J02275">
        <property type="protein sequence ID" value="AAA67108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_041242.1">
        <property type="nucleotide sequence ID" value="NC_001510.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q84365"/>
    <dbReference type="GeneID" id="1489590"/>
    <dbReference type="KEGG" id="vg:1489590"/>
    <dbReference type="Proteomes" id="UP000007019">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039526">
        <property type="term" value="P:modulation by virus of host apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039645">
        <property type="term" value="P:modulation by virus of host G1/S transition checkpoint"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039592">
        <property type="term" value="P:suppression by virus of G2/M transition of host mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039693">
        <property type="term" value="P:viral DNA genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021972">
        <property type="entry name" value="Parvovirus_NS1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001257">
        <property type="entry name" value="Parvovirus_NS1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021076">
        <property type="entry name" value="Parvovirus_NS1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12117">
        <property type="entry name" value="NS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01057">
        <property type="entry name" value="Parvo_NS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12433">
        <property type="entry name" value="PV_NSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0190">Covalent protein-DNA linkage</keyword>
    <keyword evidence="19" id="KW-0235">DNA replication</keyword>
    <keyword evidence="21" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="24" id="KW-1078">G1/S host cell cycle checkpoint dysregulation by virus</keyword>
    <keyword evidence="10" id="KW-1079">Host G2/M cell cycle arrest by virus</keyword>
    <keyword evidence="9" id="KW-1048">Host nucleus</keyword>
    <keyword evidence="24" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1119">Modulation of host cell apoptosis by virus</keyword>
    <keyword evidence="8" id="KW-1121">Modulation of host cell cycle by virus</keyword>
    <keyword evidence="12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0804">Transcription</keyword>
    <keyword evidence="18" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="19" id="KW-1194">Viral DNA replication</keyword>
    <keyword evidence="23" id="KW-0231">Viral genome packaging</keyword>
    <keyword evidence="11" id="KW-1188">Viral release from host cell</keyword>
    <feature type="domain" description="SF3 helicase" evidence="30">
        <location>
            <begin position="422"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="29">
        <location>
            <begin position="664"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00029707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00032999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00033451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="AAA67108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000007019"/>
        </source>
    </evidence>
    <sequence length="721" mass="81896" checksum="18391758E42F0DCF" modified="1996-11-01" version="1">MISGSGSLNQGAKRKWAWFKVYKQLLKSVTYLFFHSVSRDAQKESNQLTMAGNAYSDEVLGATNWLKEKSNQEVFSFVFKNENVQLNGKDIGWNSYKKELQEDELKSLQRGAETTWDQSEDMEWETTVDEMTKKQVFIFDSLVKKCLFEVLNTKNIFPGDVNWFVQHEWGKDQGWHCHVLIGGKDFSQAQGKWWRRQLNVYWSRWLVTACNVQLTPAERIKLREIAEDNEWVTLLTYKHKQTKKDYTKCVLFGNMIAYYFLTKKKISTSPPRDGGYFLSSDSGWKTNFLKEGERHLVSKLYTDDMRPETVETTVTTAQETKRGRIQTKKEVSIKTTLKELVHKRVTSPEDWMMMQPDSYIEMMAQPGGENLLKNTLEICTLTLARTKTAFDLILEKAETSKLTNFSLPDTRTCRIFAFHGWNYVKVCHAICCVLNRQGGKRNTVLFHGPASTGKSIIAQAIAQAVGNVGCYNAANVNFPFNDCTNKNLIWVEEAGNFGQQVNQFKAICSGQTIRIDQKGKGSKQIEPTPVIMTTNENITVVRIGCEERPEHTQPIRDRMLNIHLTHTLPGDFGLVDKNEWPMICAWLVKNGYQSTMASYCAKWGKVPDWSENWAEPKVPTPINLLGSARSPFTTPKSTPLSQNYALTPLASDLEDLALEPWSTPNTPVAGTAETQNTGEAGSKACQDGQLSPTWSEIEEDLRACFGAEPLKKDFSEPLNLD</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>