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<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVI7</accession>
    <name>Q6TVI7_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
            <strain evidence="1">OV-SA00</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957781.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957910.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947687"/>
    <dbReference type="GeneID" id="2947720"/>
    <dbReference type="KEGG" id="vg:2947687"/>
    <dbReference type="KEGG" id="vg:2947720"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="149" mass="15604" checksum="E2E06119A3DD96FF" modified="2004-07-05" version="1">MHPSLRRLLGALALVAAGFALGALFRPAAPPLPAAFAEAGPVRANGSASVTCLTVGDARHMAAVADAEGRLLSPAYPQGEGMHASFSSARKGALLLHVATVTVYDVRGLRDDFELTCVAVVGGYNSATAAARPRSEWLRQLERLRRAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVI8</accession>
    <name>Q6TVI8_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ORF132 vascular endothelial growth factor-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDGF/VEGF growth factor family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957909.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q6TVI8"/>
    <dbReference type="GeneID" id="2947618"/>
    <dbReference type="KEGG" id="vg:2947618"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008083">
        <property type="term" value="F:growth factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00135">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.90.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029034">
        <property type="entry name" value="Cystine-knot_cytokine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023581">
        <property type="entry name" value="PD_growth_factor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000072">
        <property type="entry name" value="PDGF/VEGF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00341">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00141">
        <property type="entry name" value="PDGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57501">
        <property type="entry name" value="SSF57501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00249">
        <property type="entry name" value="PDGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50278">
        <property type="entry name" value="PDGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0339">Growth factor</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDGF_2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAR98357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="149" mass="16246" checksum="59AC60AAA4F7F53C" modified="2004-07-05" version="1">MKLTATIQVVVALLICMYNLPKCVSQDNDSPPSTNDWVRTLDKSGCRPRDTVVYLGDEYPENTNLQYNPRCVTVKRCSGCCNGEGQICTAVETRNTTVVVSVTSVSSSSGANSGVSNNLQRISLTEHTKCDCIGRTTTPPPTTTREPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVI9</accession>
    <name>Q6TVI9_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ORF131 putative membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with G4; this interaction involves formation of a transient disulfide-bonded intermediate, allowing disulfide bond transfer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Virion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957908.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947719"/>
    <dbReference type="KEGG" id="vg:2947719"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003472">
        <property type="entry name" value="Virion_mem_poxvirus_L1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02442">
        <property type="entry name" value="L1R_F9L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAR98356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="226" mass="23656" checksum="D60E60791B710A69" modified="2004-07-05" version="1">MPPRTPPTPPHYPEPTPAAPGSLYDVFLARFLRRLAARAAPASAACAVRVGAVRGRLRNCELVVLNRCHADAADALALASAALAETLAALPAADRLAVARELGVDPEHPELTPDPACAGESALAQNIDVQTLDLGDCGDPRGRRLRVALVNSGHAAANCALARVATALTRHVPASRHGIAEGGTPPWTLLLAVAAVTVLGVVAISLLRRALQIRFRYSKPIQTLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVJ0</accession>
    <name>Q6TVJ0_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein kinase</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 6">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957907.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947718"/>
    <dbReference type="KEGG" id="vg:2947718"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008790">
        <property type="entry name" value="Poxvirus_ser/thr_kinase"/>
    </dbReference>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05445">
        <property type="entry name" value="Pox_ser-thr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="STPK_F10L"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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        <location>
            <begin position="1"/>
            <end position="53"/>
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        </location>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    </evidence>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="AAR98355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="498" mass="56856" checksum="1A135EEA85BB76D5" modified="2004-07-05" version="1">MILARAGGRPRTPAAAAAAAEDGEHSDRRKRKRKTPNCEDADNSDDELAQTPCDREWPDCRASSITSSDSVSLGDEIYLRYVASQVDFAQTWAPPVRLLRFFGNFSKETLNRMSRRGYVNRSYFQMAHARFSPTNDDMYHMATGGYGIVFRFDRYVVKYVFEHRNGMSEMDASTEYMVPRFLRNNLKGDEREFVVCALAMGLNYRLGFLHSLYRRVLHTLLLLMRAEEGQRPSVEMAKKPLLRWFEARKDSESFVRLISYFYPSAVQSNVNLINNFHHLVHFFEHEKRARYVFDRGAVIVFPLARGSADSISPEAAAALGFAPHSEFLKFVFLQIALLYLKIYELPGCTNFLHVDLKPDNVLIFDSTRALSVTAAGATFRFEEPVRAALNDFDFARVATIENRKIAGSVRVPQNWYYDFHFFSHTLLRAYPHIAAEDPGFHALLSELTVSCSRGTCDRFRLRVSSPHPIEHLARLVRRDVFSRWINAAADAPDAAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVJ1</accession>
    <name>Q6TVJ1_ORFSA</name>
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        <submittedName>
            <fullName evidence="2">ORF129 ankyrin repeat protein</fullName>
        </submittedName>
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        <name type="common">OV-SA00</name>
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        <lineage>
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            <taxon>Pokkesviricetes</taxon>
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            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="161"/>
            <end position="195"/>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <sequence length="516" mass="55506" checksum="C5EC439F58A69661" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVJ2</accession>
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    </organismHost>
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    </organismHost>
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        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
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                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
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                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-15718764">
            <id>Q6TVJ2</id>
        </interactant>
        <interactant intactId="EBI-307497">
            <id>P63208-1</id>
            <label>SKP1</label>
        </interactant>
        <organismsDiffer>true</organismsDiffer>
        <experiments>2</experiments>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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    </dbReference>
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    </dbReference>
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    </feature>
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            <end position="289"/>
        </location>
    </feature>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="501" mass="53574" checksum="5F8EB10F97243186" modified="2004-07-05" version="1">MDFLGAALYDYVADAENVRVDEVRRLLAAGASVEYAGEFGKTALHQYMGRSGTDPAVVRALLDAGARVDLPETCCGCTPVHLCLMSANIDVEVLRMLVHEGRVEDCGRAELASAVLKEFVVNRAFDENVTERVMHVLVSAGADVNAASVVDRTPLHVCLTGMSTHPGTIAALLRFGADVNAVDLCGMSPLAVLVRSRAATAELVRMLLDGGADTHAVDSRLDSLLHQHFQSARPRPEVVHELIRHGCSPRARNRIGNTPLHEAAKHSSCKHSLVGPLLAAGASVDARNNAGRTPLHLAAASNPRACRRLIALGADVVARSYAGVTPLAQLVADNNSALVTAALNTQPEPRAVAESLRATTPVGETACSRLCVAYVVARAPSEVLGEPERALHAAFVAECLAEVAAIHAVRCGTPPVSLLEILVAARPPRSLLSRRARRLAESRTTVYRAPLRARIAAMRHRSRLVERALRALRDCVLPREVLERVLRCLSTQDLRASGLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVJ4</accession>
    <name>Q6TVJ4_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF126 ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
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            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
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            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-15718558">
            <id>Q6TVJ4</id>
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            <label>SKP1</label>
        </interactant>
        <organismsDiffer>true</organismsDiffer>
        <experiments>2</experiments>
    </comment>
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        <property type="protein sequence ID" value="AAR98351.1"/>
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    </dbReference>
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    </dbReference>
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        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="2947680"/>
    <dbReference type="KEGG" id="vg:2947680"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="497" mass="52952" checksum="A8BB285807D5EE14" modified="2004-07-05" version="1">MADERGPDGALFRYLESEERPDVERMRRLLDEGADVNYAGPRGYAPLHMLMRGNPLDPDAVRLLLAAGADVNATSLCGFTPLHSYMCFGTVTPDTLCALMRHGARVSDLERNINALIEYFNRNGCMGGAEAAVIALLVEHGAYVNAKDDLGRTPLHIYLSGFFVSAPVALALIALGANPNATDAYGRTPLHAFLRSRDVDPAVLKTLIAAGADPLARDIIRRTALHYHCESFKTRASVIETLVAAGCDPASTDLLDNTALHSMAMGSSCRASLIRPLLAAGVSVNARNARLQTPLHLAAVFNPPACARLLAAGADPALSDLDETTPLLSMVRHNCARAVRTALPLAPDALVAGAVNRVNARTPSAATRECVMALALRGALDLLSAESARAHAAAIRACEAEVALLRRTRLGAPPTTLFSLLTGRPNTLISAKAARRAMADVCVYRAALAARVERVRRKSSLVERLTAMVCPCALPPELVTRILALLTVEELACAMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVJ5</accession>
    <name>Q6TVJ5_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957902.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947679"/>
    <dbReference type="KEGG" id="vg:2947679"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="173" mass="19043" checksum="99B0DCF835AAFB18" modified="2004-07-05" version="1">MANRDDIDASAVMAAYLAREYAEAVEEQLTLRERDALEALRVSGEEVRSPLLQELSNAGEHRTNPENSHIPAALVSALLETPTSPGRMVTAVELCAQMGRLWTRGRQLVDFMRLVYVLLDRLPPTADEDLGAWLQAVARVHGTRRRLHRALGVGAVVAGVGMLLLGVRVLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVJ7</accession>
    <name>Q6TVJ7_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF123 ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-15718586">
            <id>Q6TVJ7</id>
        </interactant>
        <interactant intactId="EBI-307497">
            <id>P63208-1</id>
            <label>SKP1</label>
        </interactant>
        <organismsDiffer>true</organismsDiffer>
        <experiments>2</experiments>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957900.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="DIP" id="DIP-48543N"/>
    <dbReference type="IntAct" id="Q6TVJ7">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="2947677"/>
    <dbReference type="KEGG" id="vg:2947677"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="91"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="235"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="270"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="525" mass="56481" checksum="2F801CCD0AE380E5" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVJ8</accession>
    <name>Q6TVJ8_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957899.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947663"/>
    <dbReference type="KEGG" id="vg:2947663"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="323" mass="35514" checksum="0537C5D07B65DCA3" modified="2004-07-05" version="1">MANRLVFLDPETLAEADGIPSQGVFEPGKKKCVFTKIRTSVALACRYAVSDGGLIDELVMATYGARRACRLVRHLTISAEGVMTRPASNCAPHMVLICLRGVAAVSSEDMVFGRCIMERGTMFMVKSAHSAVVCGNPACELLVLFYDHFTPIPRSLSGDEVLFTRDLAHVDYPPESAVVFKMDYDLATDVATLFVGGYIFRVRGLEMETREQVGDECDCCRHSSPVLVMDREKMMSSLRMIPSTVPGQRSICLRERGWAVLETDARGHCEPGVLRLALAGLRLFAGCLRSVVGRRELSLFCYGIVPKFGGEFDDAPRPMEIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVJ9</accession>
    <name>Q6TVJ9_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957898.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947662"/>
    <dbReference type="KEGG" id="vg:2947662"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="302" mass="34331" checksum="0DC55836AD20DAA2" modified="2004-07-05" version="1">MAGFLGAFRGVCSEIWQSLRGHGHHHSSNCPRRRANSMDERDRRRHRHREIPDSSASLNRDLMPRRSAGALRHHDRCPSEKSRHSSDRHRSADRHQSADRDRHRRGRKNYDSHPSRKNRDYERADYQGYPSQTHPDAPAQTSTLKVTSLSTSCSTLSQHHYETPDHVYDVPEDSRGASLPPCADLALPPLAMPNSKPSRRMRPASMSDFPMKHCGASKPNLQDDICTLCTDIETQLSALEKSLESELNFYRRYIQDTKTLLATRAANIGSKALIYTNDYNNSGNVGEEEHCSEECCKVEEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVK0</accession>
    <name>Q6TVK0_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957897.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947661"/>
    <dbReference type="KEGG" id="vg:2947661"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAR98345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="194" mass="20083" checksum="7F57F10971F38DE8" modified="2004-07-05" version="1">MRLILALVACLLAAPMPLSGRSTSTPNTPSALGSTSATPSSEDAAASSTTTSTTSTLTSSTSVDTTTTSGATTSNSTSAASVSSSTSATTEASTAPTTPLTPTTVKVTNGKENKASAYLAVPVMFMTMTTLAMVVVVVVLMYKQGLCNCFCKMFPCCKELKDYLDEEESAGLYDAVTWSHSNPGFRLVTRTDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVK1</accession>
    <name>Q6TVK1_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957896.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947660"/>
    <dbReference type="KEGG" id="vg:2947660"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="206" mass="22556" checksum="9625A0AD799DBE1C" modified="2004-07-05" version="1">MDSRRLALAVAFGGVLASMTQRRRLASLIASIGQRLMGGDGMRRVAVRLIDQLMAGPPDIDDEAFQREIRVGVGELFQALHRVVEQTRREKYFEVCGASNDADAPVSEMDTAAALPQPQPAPLAITPQNAFMFVPQSSHVHVDESVDPFFGMSPSIFGRDIPLQPPEELLSDYDPLMSQAGEPPSPRSPCEADLWCFETLNDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVK2</accession>
    <name>Q6TVK2_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957895.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947659"/>
    <dbReference type="KEGG" id="vg:2947659"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="102" mass="11504" checksum="105E3876839A5951" modified="2004-07-05" version="1">MSFQRGNRSIRPAMSEALQNDFSYNPRPPPPSAEEIDFFCVDMRKVLMEIEAKPSSSKYPDFIHPVDSSPPCTPARKRNGSGRKAPNKTPVPQHAKRDGYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-09-29" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVK3</accession>
    <name>Q6TVK3_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF117 GM-CSF/IL-2 inhibition factor-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957894.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q6TVK3"/>
    <dbReference type="GeneID" id="2947658"/>
    <dbReference type="KEGG" id="vg:2947658"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036540">
        <property type="entry name" value="Pox_vCCI-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49889">
        <property type="entry name" value="SSF49889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="265" mass="30117" checksum="890DD6909D5B5D3A" modified="2004-07-05" version="1">MACLRVFLAVFALCGSVHSAQWIGERDFCMAHAQDVFARLQVWMRIDRNVTAADNNSACALAIETPPSNFDADVYVAAAGINVSVSAINCGFFSMRQVETTYDTARRQMYVYMDTWDPWVLDDPQPLFSQEYENETLPYLLEVLELARLYIRVGCTVPGEQPFEVITGIDYPHTSMEFLQHVLRPNRRFAPAKLHMDLEVDYRCVSAVYVKAFLQDACSARKARTPLYFAGHGSNHPDRRPKNPVPRPQHVSSPMSRKCLMQTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVK5</accession>
    <name>Q6TVK5_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957892.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947700"/>
    <dbReference type="KEGG" id="vg:2947700"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="149" mass="16705" checksum="57BB53F01A877D3A" modified="2004-07-05" version="1">MACLIEWVDSIFNRRHRNFGPEDMYRPSDPTPPSKSRTPRTPHQHTPRNRCPERPRRHNSSPICGACVDSLPRNRKRFQHRHSCPGDYEQCQLSETISLEATLLTVTTTSISSISSIYSSSSSDSISLGQCRLSMVSATSTSTTFSSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVK6</accession>
    <name>Q6TVK6_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957891.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947699"/>
    <dbReference type="KEGG" id="vg:2947699"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009641">
        <property type="entry name" value="Vaccinia_virus_A37"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06822">
        <property type="entry name" value="DUF1235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="344" mass="37546" checksum="973B16657156C5AE" modified="2004-07-05" version="1">MPLFRKLMVSRALVKECLTLDFRQGERLPTRCFLPVPAGTTFHRVCDTSPLTNEVSRHVQEPVMGTGRVQYYYFESGQGMIGDNAGTPRMLVCTRSAYNGGDVVVRSTRSRADKTVVAPCQGMVLLLSPFCAFDITPVESGSAIFAEVTVGAPSMDHVEAVAGDGDAAVRIFNSHHPLWPRHGSNVCFALRLLRDARTGERVVEQMFIDGRWHTVLRTSCGNKVCVPADLVGQTNLEEVPFCDVTPDIMRRALAIDPPYEAVAHPRRCVYGAMDVRCANEYLVYCTFKTEPARRSTSSPGPDGPLSPATPSASQPAAARAPTTPQEVTSPTTKLVETCLRDALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVK7</accession>
    <name>Q6TVK7_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957890.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947698"/>
    <dbReference type="KEGG" id="vg:2947698"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAR98338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="200" mass="21316" checksum="7901F8A0B5A848BC" modified="2004-07-05" version="1">MEVLVIISIIVAVIFLTGAAIYLLIELGLAAERANKRARVKKNMRKLATQLGNGSVDSGIGPCTISRTMDFGPSRWDSDSEGDGDSLSTTSTSGGGTLPRVWVGGGPGPMYENFCGNGTHRHSPTNDPGYHSRETLCSGPPRQAPEPLTTPKPDEVKVEVGPGPDDRQGLYEEPEPVQIEVTVNGPGGEGEEEGEFFYDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVL1</accession>
    <name>Q6TVL1_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF109 EEV glycoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957886.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q6TVL1"/>
    <dbReference type="GeneID" id="2947639"/>
    <dbReference type="KEGG" id="vg:2947639"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009238">
        <property type="entry name" value="Chordopox_A33R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05966">
        <property type="entry name" value="Chordopox_A33R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="164" mass="18334" checksum="826CDD376310C4BF" modified="2004-07-05" version="1">MAHNTFETDSESANNANYVASVKRQKAIRRYIKLFFRIVAAIAIIVLAILVVLLALELDKCKEQSTHQDYHHTTNKTCDGLFPENKWCLTKFDPFTLRQAKSMCTGIGQTLPSEDIVKLYPWLGKYLTGTWSDKGGVFGSSGSTSEVWSGASEQEKAFFCVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVL3</accession>
    <name>Q6TVL3_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ORF107 virion morphogenesis</fullName>
        </submittedName>
    </protein>
    <organism evidence="5">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the association between the dense viroplasm and the viral membranes to form the mature virion (MV).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chordopoxvirinae A30 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957884.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947637"/>
    <dbReference type="KEGG" id="vg:2947637"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009257">
        <property type="entry name" value="Chordopox_A30L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06015">
        <property type="entry name" value="Chordopox_A30L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAR98332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="60" mass="6432" checksum="36BBD39499909E85" modified="2004-07-05" version="1">MEEDLNEAGLLHMLTRIAQICGGDAAAAAATIKMLMDLVNERIMILNKKAKKEMGQASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVL6</accession>
    <name>Q6TVL6_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ORF104 fusion protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957881.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q6TVL6"/>
    <dbReference type="GeneID" id="2947685"/>
    <dbReference type="KEGG" id="vg:2947685"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019064">
        <property type="term" value="P:fusion of virus membrane with host plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003436">
        <property type="entry name" value="Chordopox_Fusion/A27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02346">
        <property type="entry name" value="Vac_Fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01847">
        <property type="entry name" value="VIRALFUSION"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAR98329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="90" mass="10163" checksum="CADB8AEDB2B0A3FC" modified="2004-07-05" version="1">MEENDGENLLAQPDDDTGNSTNGVYAAGAPTKESVEERLVSLLDSYKTITDCCRETGNRLDRLEKHLETLRRALLDLNRKIDVQTGYSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVL7</accession>
    <name>Q6TVL7_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF103 A type inclusion protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957880.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947684"/>
    <dbReference type="KEGG" id="vg:2947684"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009285">
        <property type="entry name" value="Orthopox_A30L/A26L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06086">
        <property type="entry name" value="Pox_A30L_A26L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="516" mass="60266" checksum="7FCA7A4D52CF946D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVL8</accession>
    <name>Q6TVL8_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF102 A type inclusion protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957879.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947683"/>
    <dbReference type="KEGG" id="vg:2947683"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009285">
        <property type="entry name" value="Orthopox_A30L/A26L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06086">
        <property type="entry name" value="Pox_A30L_A26L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="520" mass="60382" checksum="0F2A6CC68DC4AB6F" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVM0</accession>
    <name>Q6TVM0_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Intermediate transcription factor 3 large subunit</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts with RNA polymerase to initiate transcription from intermediate gene promoters.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poxviruses A23 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957877.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947715"/>
    <dbReference type="KEGG" id="vg:2947715"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008789">
        <property type="entry name" value="Poxvirus_intermed-TF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05718">
        <property type="entry name" value="Pox_int_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAR98325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="380" mass="41902" checksum="E1B1E3737E29E481" modified="2004-07-05" version="1">MLALFEFLRSVEDCYRRTIFNFHIAHSAEAGDVYGVLRDRILAATRFEEVAPPGLADALAKVVYCDISTTKHLVNHAAFAARARSARRGGSLAQFFDVHVGEDAESRRTAEIFDRERSSLVSYVKTTAKRCKIDYGEIKRTIHGGRQTYFSGRRSDDFLSTTVRADPSKPWIKSISKQLRVDILHHAICTRGKSSILQTIEVVLTNRTCVKIFKDSTMHIILSKDDRERGLADLADKLFGTYATTFRVIAAITGNACFAAVADAAARVVALPDADAKLEAVRGLADCYGVRNFKIGMFNLTFTGAIEHTVFPSLIPAESKIKFFKGKKLNIVAVRSTEEGRECVEQAQALLAAMRERSARLAAADVATASVDFLKELLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVM1</accession>
    <name>Q6TVM1_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ORF099 Holliday junction resolvase</fullName>
        </submittedName>
    </protein>
    <organism evidence="4">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RuvC family. Poxviruses-type subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957876.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947714"/>
    <dbReference type="KEGG" id="vg:2947714"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006932">
        <property type="entry name" value="HJ-resolvase_A22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04848">
        <property type="entry name" value="Pox_A22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAR98324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="146" mass="16720" checksum="DD19183533C6D0A8" modified="2004-07-05" version="1">MIVAAFDLGTRNPARTVLEVLDGTVRVVDVAKLDWSRDWEKRVHRDVTAFPANVVLVERQCKMSPFSKFIYFIRGLLYDGRRRTRVLAVPPAMTGSTYRQRKRRSVRTFLALAESFGILDAVPARKKLDDVADSFNMAINYVLRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVM2</accession>
    <name>Q6TVM2_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase processivity factor component A20</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an essential role in viral DNA replication by acting as the polymerase processivity factor together with protein D4. May serve as a bridge which links the DNA polymerase E9 and the uracil DNA glycosylase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with the DNA polymerase catalytic subunit E9. Interacts with UDG. Component of the Uracil-DNA glycosylase(UDG)-A20-polymerase complex; A20 and UDG form a heterodimeric processivity factor that associates with E9 to form the processive polymerase holoenzyme. Interacts with D5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the poxviruses A20 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957875.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947713"/>
    <dbReference type="KEGG" id="vg:2947713"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010267">
        <property type="entry name" value="Chordopox_A20R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05941">
        <property type="entry name" value="Chordopox_A20R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAR98323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="429" mass="47287" checksum="EF12AEA7D631D5F5" modified="2004-07-05" version="1">MTSESDLYTLKELIRLRDSLHLATGAAVERYNALVEWAARTYWTVAVLPSAPCASIEKYYCVCKPDCALEPGEYSVSRLHFGLTHAWVRGAAFNSASGAEVEPPEEVRRACEALDAAFADLTFVRFSVFGREWTVDDAVTDHSSRDEVLAACAASGVRVARTLRVRVRAGESFAREDFDAVHAALRAEGDVARGTAVCLALRGSARRWIADRAPRCFVRVRRVELEPVDARHHCPVLISARGDRVLCRGVGHLADARAREGVFVAVRRYPECLVLCDEAAAGAADCSREEALRLLVRRFGRDFAVSEEGYVFRVQDMDLRGVSARLGLAPCASLEELRRAVERDRALMRRLRAEGAVRLACECMGYPRQNAVELINNMRFQITEEGAVANFELANASCLGNPTAESIFASFAQFVPIFNVLSAIARAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVM3</accession>
    <name>Q6TVM3_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Envelope protein part of the entry-fusion complex responsible for the virus membrane fusion with host cell membrane during virus entry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type III membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Virion membrane</location>
            <topology evidence="3">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the chordopoxvirinae A21 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957874.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947712"/>
    <dbReference type="KEGG" id="vg:2947712"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039663">
        <property type="term" value="P:membrane fusion involved in viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007987">
        <property type="entry name" value="Poxvirus_A21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05323">
        <property type="entry name" value="Pox_A21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1168">Fusion of virus membrane with host membrane</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1162">Viral penetration into host cytoplasm</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <keyword evidence="5" id="KW-1160">Virus entry into host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAR98322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="108" mass="11698" checksum="C164BF5B9B0F9C30" modified="2004-07-05" version="1">MISLFLLICYFVLIFNILVPRIFDKLRQEGAAFDRLAGSGNVYRCVGDVVVSYALGATGISARVMTDEKGAPLPCARIAEADSARFARCGARADLRDVCANAYADVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVM5</accession>
    <name>Q6TVM5_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ORF095 DNA helicase</fullName>
        </submittedName>
    </protein>
    <organism evidence="5">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957872.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947645"/>
    <dbReference type="KEGG" id="vg:2947645"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="104"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAR98320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="488" mass="53959" checksum="BD3D5F0DEF1D26C3" modified="2004-07-05" version="1">MFGGVQVDDKLYAYLKKLAGRGRPLCLFRDNGEFVEVFAGSAFRFVLPVGLFADLRVRTRGVAFPKLRDSARMRGVRVDAHTLPSLYPNQRIVVDEVLAARDQLLAAGRAVYVTLHLACGFGKTLTACHLIATHGRRAVVCVPNRMLVPQWRAAVAELRVPFAVSCDGAASLLRSGELDRAMVAIVVSRHFANDDFCRAVSRQFDVLVLDESHTYNLMNNTAVSRFLTKYPPPMCFFLTATPRTANRIYCNRVVNVSVVSRLTKVVRVVDAFFEPYTTPKIRTLERSLEGPQNKYHVFTEKILGEDVHRNKLIVDTVVAAMAAGEARRVLVLTKLREHMVGLHAALRERLGAETVFLGDAKNRKTPEVTRALRDKDRFVLVSTVFFSGTGLDLPNLDALAVAAAVLNRMVMEQMIGRVCRESHANTRTLFVFPDSSVRAIRDTVSAFAQRLVALAVDGLGFVRERSAAGAKNEPALYSAISGRDLAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVM6</accession>
    <name>Q6TVM6_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ORF094 putative phosphorylated IMV membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Envelope protein which participates in virus morphogenesis. Needed for an early step in viral crescent membrane formation by interacting with D13 scaffold protein. Its interaction with D13 scaffold protein leads to the formation of rigid, crescent-shaped membranes that assemble around the cytoplasmic virus factory. Membrane anchor for the protein A27. A17-A27 virus envelope protein might be involved in fusion or attachment, and can further associate to A26.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Virion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the chordopoxvirinae A17 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957871.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947644"/>
    <dbReference type="KEGG" id="vg:2947644"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007977">
        <property type="entry name" value="Poxvirus_P21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05313">
        <property type="entry name" value="Pox_P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAR98319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="196" mass="20907" checksum="721F87B38EF5B585" modified="2004-07-05" version="1">MESYFSYYNDEFTAGGVQDAELFSPEEQNAFLPKDPGTADSPLVPATPRPVPGGNIAPYSVLQYEDIRILTGIVIFVLALTSTPVLALVMIGIASLILPLPCLVIGYCAAMQIMHPYAANNTGMAIVCTIMSIVTIIVTHVTGSVGATTFMYIVLGLLFAIYAFRLTGRGIVRTRSAAPACPVYAGAKSEDLFFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVM9</accession>
    <name>Q6TVM9_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF091 putative IMV membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957868.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947641"/>
    <dbReference type="KEGG" id="vg:2947641"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009372">
        <property type="entry name" value="Poxvirus_A14.5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06269">
        <property type="entry name" value="DUF1029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="53" mass="6093" checksum="BC4FA849051EB566" modified="2004-07-05" version="1">MVSDYDPAVLVFIFCMALAANFCMPMKTKLSTIFVLQSVVFSWFLFHFVHSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVN0</accession>
    <name>Q6TVN0_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ORF090 putative IMV phosphorylated membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Envelope protein which is a major component of the mature virion (MV) membrane. Essential for membrane biogenesis. Is required, together with A17, to form bona fide crescents, which can progress to form the immature virion (IV) membrane. A14 and A17 form a lattice that is stabilized by disulfide bonds and serves as an anchor within the viral membrane to which several other proteins important in virion structure and morphogenesis attach.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer; disulfide-linked. Interacts with A17.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Virion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the chordopoxvirinae A14 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957867.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947710"/>
    <dbReference type="KEGG" id="vg:2947710"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008785">
        <property type="entry name" value="Poxvirus_A14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05767">
        <property type="entry name" value="Pox_A14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAR98315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="91" mass="10084" checksum="EA28C0F308735067" modified="2004-07-05" version="1">MDIFETLSSYYSGVLICGVLLLTAACVFAFVDFSKNTSNITDYVWRALCVTCFIVGAVLLLGLFVFSMYRKCSGSVPYARLNNTDIELTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-10-07" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVN1</accession>
    <name>Q6TVN1_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ORF089 virion membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="13">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for the encapsidation of DNA into immature virions (IV) and the subsequent maturation of IV into mature virions (MV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Virion membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the chordopoxvirinae A13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957866.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947709"/>
    <dbReference type="KEGG" id="vg:2947709"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009236">
        <property type="entry name" value="Chordopox_A13L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05961">
        <property type="entry name" value="Chordopox_A13L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0426">Late protein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="AAR98314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="92" mass="9767" checksum="70C5B66CA764FF4E" modified="2004-07-05" version="1">MGLLDALLTVIVISIVCYIVIMMYRRSCVSAPAVPRNKDLLPPGASSFEDKMTDDQVRAFHALVTSSSGDNPAPAPTAESPVARNRFSAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVN2</accession>
    <name>Q6TVN2_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25 kDa core protein A12L</fullName>
        </recommendedName>
    </protein>
    <organism evidence="8">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the virion core that undergoes proteolytic processing during the immature virion (IV) to mature virion (MV) transition. Essential for the formation of a structurally normal core.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chordopoxvirinae A12 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957865.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947708"/>
    <dbReference type="KEGG" id="vg:2947708"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006744">
        <property type="entry name" value="Poxvirus_A12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04651">
        <property type="entry name" value="Pox_A12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0426">Late protein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="59"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAR98313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="260" mass="26606" checksum="A02B033FEAF6B5A9" modified="2004-07-05" version="1">MASEKMAQRPQSSYDDYVNTLQKIAPHLRSLLTQLNNEQVIRGGATSGDVDCVGGAGALEASSSSTRRGSSSSSSRKRTTGTRSTGSRSTGSRSSGTRSSSSTRSRRSGAPSRRNNDGVYSGMNACDDETTIQAVSNCGKIVYGVVKNGKLDVQGTVGEVCEDLLGIDSVNGGRKKSSSGKSGTGTSRRGGTGTGTGRSSTSGTTGRRSTNSGTSSSASSSRRRASSSNTPCSTTSSASTGARRRASNLMNAMDLDSGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVN4</accession>
    <name>Q6TVN4_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major core protein 4a precursor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Virion core protein 4a precursor</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Core protein 4a is the most abundant virion protein. Major component of the virion core that undergoes proteolytic processing during the immature virion (IV) to mature virion (MV) transition.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with P39/A4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poxviridae protein P4a family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957863.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947706"/>
    <dbReference type="KEGG" id="vg:2947706"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044423">
        <property type="term" value="C:virion component"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005058">
        <property type="entry name" value="Poxvirus_P4A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03395">
        <property type="entry name" value="Pox_P4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAR98311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="905" mass="99903" checksum="8EC351BDA86FB74D" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVN5</accession>
    <name>Q6TVN5_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="16">ORF085 late virion membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="17">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Envelope protein. Required for an early step in virion morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Virion membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the chordopoxvirinae A9 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957862.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947724"/>
    <dbReference type="KEGG" id="vg:2947724"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006920">
        <property type="entry name" value="Poxvirus_A9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04835">
        <property type="entry name" value="Pox_A9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="9" id="KW-0426">Late protein</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="44"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="AAR98310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="93" mass="10293" checksum="AE41EB42E79F7DD8" modified="2004-07-05" version="1">MRPCYVTVIKSIGGLALFQVANGAIDLMRHLFMHFCEHRLRSNTFAAVVFKTVISMIMYLLLGVALIYMFSDPECSGGERTPTSMATRGTQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVN7</accession>
    <name>Q6TVN7_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Early transcription factor 82 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ETF large subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Acts with RNA polymerase to initiate transcription from early gene promoters. Is recruited by the RPO-associated protein of 94 kDa (RAP94) to form the early transcription complex, which also contains the core RNA polymerase. ETF heterodimer binds to early gene promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of a 70 kDa and a 82 kDa subunit. Part of the early transcription complex composed of ETF, RAP94, and the DNA-directed RNA polymerase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the poxviridae VETF large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957860.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947722"/>
    <dbReference type="KEGG" id="vg:2947722"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007532">
        <property type="entry name" value="Poxvirus_early-TF_lsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04441">
        <property type="entry name" value="Pox_VERT_large"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAR98308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="841" mass="95281" checksum="65631EA7CE095B7A" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-09-29" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVN8</accession>
    <name>Q6TVN8_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an essential role in immature virion (IV) to mature virion (MV) transition.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the chordopoxvirinae A6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957859.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947721"/>
    <dbReference type="KEGG" id="vg:2947721"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007008">
        <property type="entry name" value="Poxvirus_A6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04924">
        <property type="entry name" value="Pox_A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAR98307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="378" mass="43061" checksum="27D0B03EAD35A122" modified="2004-07-05" version="1">MDRLRTCYERFYDISRDHLSRGTGLCVDCLDFDTDVDTLVSMVPVLESSVCPIAPEMSEADVLALMKHFNYQALSFWFLKSNAVAKSVYNSIADAEGKREFARVFRDVLLAAQTLVSLNAMYRNMRNDTEEIIDDSKKIMEMISHVRGASGANAVMKILQNHYSFLVKCLNKVFSDENYVLKLVAVFDNSLMTDKQKLKEYQELLRVSAESAEHGIRCVSDLEVSSVSVDGDRAKYLNFMKKVMSSMLVFQNKDLKPAKFATVVCKLYVVLYNEFKTNVEIGKLVRDVFVSLREKFSPQDLKSVGVKNIQTLVRYVANHRALYKEVLAREYWEREGSLVDIAQSVISENGITYRGCPIVVRELLDMIKEKISEAAESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVP1</accession>
    <name>Q6TVP1_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major core protein 4b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Virion core protein 4b</fullName>
        </alternativeName>
    </protein>
    <organism evidence="9">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Major component of the virion core that undergoes proteolytic processing during the immature virion (IV) to mature virion (MV) transition. Essential for the formation of a structurally normal core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poxviridae protein P4b family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957856.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947727"/>
    <dbReference type="KEGG" id="vg:2947727"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004972">
        <property type="entry name" value="P4B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03292">
        <property type="entry name" value="Pox_P4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="64"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAR98304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="675" mass="74054" checksum="5D423AAE47DEDC48" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVP2</accession>
    <name>Q6TVP2_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF078 thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957855.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947726"/>
    <dbReference type="KEGG" id="vg:2947726"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007952">
        <property type="entry name" value="Poxvirus_A3L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05288">
        <property type="entry name" value="Pox_A3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="83" mass="9580" checksum="0133391F4623B146" modified="2004-07-05" version="1">MDRDDVWFAAYSVELDPPRRCTRCSLNLTRFINEDPENARMLLLSQPGRARALAGFLQFCRTRTLDTKVLDREILRVLGLGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVP3</accession>
    <name>Q6TVP3_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Viral late gene transcription factor 3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="12">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts with RNA polymerase to initiate transcription from late gene promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the late transcription elongation factor H5/VLTF-4. Interacts with the late transcription factors VLTF-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleo-cytoplasmic large DNA viruses (NCLDVs) VLTF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957854.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947725"/>
    <dbReference type="KEGG" id="vg:2947725"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046782">
        <property type="term" value="P:regulation of viral transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007031">
        <property type="entry name" value="Poxvirus_VLTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014900">
        <property type="entry name" value="VLTF-3_Zn_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08792">
        <property type="entry name" value="A2L_zn_ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04947">
        <property type="entry name" value="Pox_VLTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0426">Late protein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A2L_zn_ribbon" evidence="10">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAR98302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="224" mass="26333" checksum="CB3BB73C44D5FDBF" modified="2004-07-05" version="1">MNLRMCGGCRRNGLVSDADYEFCLFCETVFPMGIRVQKRSNFHVSNKLIHLRNVLRRLLSKQCSEEVIRDLRAMMDRHQIRPEDVDANYVSSFLKDSEMINKKDYKLVFEIINQVKNEKLDLSTEKINEVIEIFKQLVFFCQEITPTKTINYSFFLDKIFEVTGVTRNLRPQTVKNYAKNNSNQLTWENFLAHMRARKRAAQIPEFGHEYVFSPARFAACSLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVP5</accession>
    <name>Q6TVP5_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">62 kDa protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Rifampicin resistance protein</fullName>
        </alternativeName>
    </protein>
    <organism evidence="7">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poxviridae protein D13 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957852.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947675"/>
    <dbReference type="KEGG" id="vg:2947675"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005008">
        <property type="entry name" value="Poxvirus_Rif-R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03340">
        <property type="entry name" value="Pox_Rif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAR98300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="545" mass="60515" checksum="A1DD9A57E29ABDE6" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVP6</accession>
    <name>Q6TVP6_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF074 mRNA capping enzyme small subunit</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957851.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947674"/>
    <dbReference type="KEGG" id="vg:2947674"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005009">
        <property type="entry name" value="Poxvirus_mRNA-cap_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043096">
        <property type="entry name" value="Poxvirus_mRNA-cap_ssu_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03341">
        <property type="entry name" value="Pox_mRNA-cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="300" mass="33936" checksum="5E80826758A165D8" modified="2004-07-05" version="1">MKTDCASNKSAMDAVEAVRRSIREGLSVTLPTFDSTPALDLQLGVGHLPSLAYGTNYFLQCSRVNDINRMPTEMLSLYTHDLMIDERDVEKVLEAHGITSVRSRARGRADAVVLDLSARNRLYRKERGAIRSNNHLTENNLYVADYHAITFAVMRPLLEITQERFVVLKLPTLFGTDVVHALRVYCSLFGTVRLFKCVSDSWLKDSAVMVASEPRRAAIAAFVTHVRERTKAAAWRDSLAVPFRVLKDPVESEFVDRFVAFASRVYEALYVTHSLLYESMTSESKSIENESQRKLKLLLQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2017-12-20" modified="2022-02-23" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVP7</accession>
    <name>V073_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName>Protein ORFV073</fullName>
        </recommendedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2017" name="PLoS Pathog." volume="13" first="E1006561" last="E1006561">
            <title>A parapoxviral virion protein inhibits NF-kappaB signaling early in infection.</title>
            <authorList>
                <person name="Khatiwada S."/>
                <person name="Delhon G."/>
                <person name="Nagendraprabhu P."/>
                <person name="Chaulagain S."/>
                <person name="Luo S."/>
                <person name="Diel D.G."/>
                <person name="Flores E.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="28787456"/>
            <dbReference type="DOI" id="10.1371/journal.ppat.1006561"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>INTERACTION WITH HOST IKBKG</scope>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in the inhibition of the host NF-kappa-B pathway early during infection. Prevents the host RELA subunit from reaching the nucleus and activate transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with host IKBKG; this interaction inhibits host NF-kappa-B pathway activation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
            <location evidence="1">Host perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957850.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q6TVP7"/>
    <dbReference type="GeneID" id="2947673"/>
    <dbReference type="KEGG" id="vg:2947673"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-1035">Host cytoplasm</keyword>
    <keyword id="KW-1048">Host nucleus</keyword>
    <keyword id="KW-0945">Host-virus interaction</keyword>
    <keyword id="KW-1100">Inhibition of host NF-kappa-B by virus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0946">Virion</keyword>
    <feature type="chain" id="PRO_0000442579" description="Protein ORFV073">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="28787456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="188" mass="22075" checksum="CD8BEA953F2A9C7B" modified="2004-07-05" version="1">MARRARFSPRLHIPAARAALGPHLHFPRRRLVLRHCGVRAFVGDAIVSKKEMTNPLCAQAIVFGNGFVETYVRSLDPRLLGAYHALSRPVCERPLFAVRGWRRLFPIVARRLDAVERRTRRVLRSMCRTYTTCMSADRAAAVSHPVMRRRWFGHRATKTRRARLRRRCRNRSSKRRAERRKRFCNYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVP8</accession>
    <name>Q6TVP8_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleoside triphosphatase I</fullName>
            <ecNumber evidence="3">3.6.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nucleoside triphosphate phosphohydrolase I</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="EC" id="3.6.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. NPH I subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.15" evidence="3"/>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957849.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947672"/>
    <dbReference type="KEGG" id="vg:2947672"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013676">
        <property type="entry name" value="NPHI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08469">
        <property type="entry name" value="NPHI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="43"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAR98297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="638" mass="71025" checksum="D1CAC14A43DECA37" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVP9</accession>
    <name>Q6TVP9_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA-decapping protein D10</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Decapping enzyme required for the removal of the 5'-end m7GpppN cap tethered to viral and host mRNAs to allow their decay in cells. May therefore accelerate viral and cellular mRNA turnover to eliminate competing host mRNAs and allow stage-specific synthesis of viral proteins. Acceleration of the turnover of cellular transcripts may even promote the shutoff of host protein synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957848.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947613"/>
    <dbReference type="KEGG" id="vg:2947613"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003301">
        <property type="entry name" value="Vaccinia_D10_decapping"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013683">
        <property type="entry name" value="Vaccinia_D10_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08476">
        <property type="entry name" value="VD10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01364">
        <property type="entry name" value="VD10PROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="42"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAR98296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="224" mass="24704" checksum="20E5ADF2D16D5552" modified="2004-07-05" version="1">MRTYTSLLSKLLKSNRRLGSTRVFRDPLQHISATAFVHRRIDRHRRVSICAVLTTTDGLVVACRRRYSFLSSELAETRSPARRVLLATKHADALARLGAARPRDDVMFPGGAPLSGESPLACVLREVEEETGLRGDQVNVDERLFVHAFIDDLVSGRDFDAIIFTGAVALSSAEVAKQFRPNDEVKGLVFLRPEDAEGVGVMARLAAFARCAARLRCWGAAVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVQ1</accession>
    <name>Q6TVQ1_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ORF069 early transcription factor VETFs</fullName>
        </submittedName>
    </protein>
    <organism evidence="8">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957846.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947631"/>
    <dbReference type="KEGG" id="vg:2947631"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="32"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAR98294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="635" mass="71904" checksum="A017761D4A1AC415" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVQ3</accession>
    <name>Q6TVQ3_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ORF067 uracil DNA glycosidase</fullName>
        </submittedName>
    </protein>
    <organism evidence="9">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Also part of a heterodimeric processivity factor which potentiates the DNA polymerase activity. Binds to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957844.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947629"/>
    <dbReference type="KEGG" id="vg:2947629"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAR98292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="231" mass="26014" checksum="1C9303404711998F" modified="2004-07-05" version="1">MATPANAPALPVAALRHRPYRVEYHPDWEPVIETLVDEYDAVAPWLLRDATSPEPERFFAQLAKPLADKRVCVCGIDPYPRGGTGVPFQSPDFSKKTIRAIASSVARTTGTRGYANYDLDAVPGVLPWNYYLSCREGETKSHAMYWERISRLLLQHVAKHVSVLYCMGRTDFQNVRARLDVPVTLVVGFHPAARDGQFARERAFEVINALLELNGKSQVDWARGFSFYSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVQ5</accession>
    <name>Q6TVQ5_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ORF065 virion protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="7">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Late protein which is part of a large complex required for early virion morphogenesis. This complex participates in the formation of virosomes and the incorporation of virosomal contents into nascent immature virions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chordopoxvirinae D2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957842.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947627"/>
    <dbReference type="KEGG" id="vg:2947627"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006791">
        <property type="entry name" value="Pox_D2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04701">
        <property type="entry name" value="Pox_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0426">Late protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAR98290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="156" mass="17241" checksum="D1AEEB72992A3470" modified="2004-07-05" version="1">MEPSAMREDLHALKSLVALAPSLDRVGAALAWRHVLVERDHRGAPARVHRFDRALRLDNRSALRAVKAVFGHRSRMMRALFPSRAVFEALEPLPPAETLVLRAAREPPPDDGGPIDARETAAWLAELFNAFRAGAGAESTPWFCLPLAEDVQHVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVQ6</accession>
    <name>Q6TVQ6_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mRNA-capping enzyme catalytic subunit</fullName>
            <ecNumber evidence="3">2.1.1.56</ecNumber>
            <ecNumber evidence="4">2.7.7.50</ecNumber>
            <ecNumber evidence="5">3.1.3.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="23">Virus termination factor large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">mRNA-capping enzyme 97 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">mRNA-capping enzyme large subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="26">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the mRNA capping enzyme which catalyzes three enzymatic reactions: the 5' triphosphate end of the pre-mRNA is hydrolyzed to a diphosphate by RNA 5' triphosphatase; the diphosphate RNA end is capped with GMP by RNA guanylyltransferase and the GpppN cap is methylated by RNA (guanine-N7) methyltransferase. Heterodimeric mRNA capping enzyme catalyzes the linkage of a N7-methyl-guanosine moiety to the first transcribed nucleotide (cap 0 structure), whereas the polymerase associated VP39 is responsible for a second methylation at the 2'-O position of the ribose (cap 1 structure).</text>
    </comment>
    <comment type="function">
        <text evidence="19">The heterodimeric enzyme is also involved in early viral gene transcription termination and intermediate viral gene transcription initiation. Early gene transcription termination requires the termination factor VTF, the DNA-dependent ATPase NPH-I and the Rap94 subunit of the viral RNA polymerase, as well as the presence of a specific termination motif. Binds, together with RAP94, to the termination motif 5'-UUUUUNU-3' in the nascent early mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-(ribonucleoside) in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5'-end triphospho-(purine-ribonucleoside) in mRNA + H2O = a 5'-end diphospho-(purine-ribonucleoside) in mRNA + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11008"/>
            <dbReference type="Rhea" id="RHEA-COMP:13929"/>
            <dbReference type="Rhea" id="RHEA-COMP:13942"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138276"/>
            <dbReference type="ChEBI" id="CHEBI:138288"/>
            <dbReference type="EC" id="3.1.3.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="20">Heterodimer of a catalytic and a regulatory subunit. Intrinsic methyltransferase activity of the catalytic subunit is weak and needs to be stimulated 30- to 50-fold by the regulatory subunit, which is itself catalytically inert.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.56" evidence="3"/>
    <dbReference type="EC" id="2.7.7.50" evidence="4"/>
    <dbReference type="EC" id="3.1.3.33" evidence="5"/>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957841.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947657"/>
    <dbReference type="KEGG" id="vg:2947657"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019602">
        <property type="entry name" value="mRNA_cap_ATPase/GuylTrfase_vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="PTHR12189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10640">
        <property type="entry name" value="Pox_ATPase-GT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="Pox_MCEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="24">
        <location>
            <begin position="513"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00025126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00025807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00033397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="AAR98289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="841" mass="95261" checksum="C54A3CFF02F080F4" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-10-07" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVQ7</accession>
    <name>Q6TVQ7_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chordopoxvirinae H7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957840.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947656"/>
    <dbReference type="KEGG" id="vg:2947656"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006872">
        <property type="entry name" value="Poxvirus_H7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04787">
        <property type="entry name" value="Pox_H7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAR98288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="138" mass="15135" checksum="F2207564BA06655E" modified="2004-07-05" version="1">MDEALRVAARVVDGLRPLDVAVCLVQLRGAAPERRFPALDERSGEAFLDFEFAGGDVASRYLSAHTRELCAAERREHMAAIARCVTEADLALADRPRGKARAALRVCRNREKVSRLARLLRDAESSGADFAFIRAAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVQ8</accession>
    <name>Q6TVQ8_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase I</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957839.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947655"/>
    <dbReference type="KEGG" id="vg:2947655"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.66.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035447">
        <property type="entry name" value="DNA_topo_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027362">
        <property type="entry name" value="TopoI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015346">
        <property type="entry name" value="TopoI_N_vir"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09266">
        <property type="entry name" value="VirDNA-topo-I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55869">
        <property type="entry name" value="SSF55869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0426">Late protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="VirDNA-topo-I_N" evidence="8">
        <location>
            <begin position="4"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisom_I" evidence="7">
        <location>
            <begin position="91"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAR98287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="318" mass="36207" checksum="B7C44C4DCE076454" modified="2004-07-05" version="1">MRALHLSDGKLFFDKELTQPVPDDNPAYAVLAKIRIPPHLSDVVVYEQDLESAQQGLIFVGRDAKGRKQYFYGRGHVERRTAVRNAVFVRVHRVMHKINAFIDDHLASGSEAEAQMAAFLLMETSFFIRVGKTRYERESGTVGMLTLRNKHLAEAEGGEEIRVAFVGKDRVAHEFAVREGQRLFAALRRLWDPGAPDRLLFDRLSERRVYTFMRRFGIRVKDLRTYGVNYTFLYNFWSNVRSLEPRPSVKSLICTSVRQTAETVGHTPSISRSAYMATAVLELVRDGAFLDRVAATDTLDDFVDIVVDYVNNSEQVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVQ9</accession>
    <name>Q6TVQ9_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF061 late transcription factor VLTF-4</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957838.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947654"/>
    <dbReference type="KEGG" id="vg:2947654"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004966">
        <property type="entry name" value="Pox_Ag35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03286">
        <property type="entry name" value="Pox_Ag35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="227" mass="24593" checksum="2311D6DCC7C1DDBB" modified="2004-07-05" version="1">MSSWRLKMSKCSGSSSVQTLEDLRNRLRSEALGSDCQEPRDDLFPNGEECLDIDGPCSPCDEAEQELDQEQLPVPETVPELPAKTPKRRPAKKDKADKPEKSTKGAKKLCPPDDKDDELESNDVDNNEESGDAEGGASARSPSDIDNVDEMDDSDLMVAFSAILADFKDLTQRVKALSSVLTDVQATGIRRSFSTLGKALTEAAHIANTGAKPVTAPRKKKAATCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVR1</accession>
    <name>Q6TVR1_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ORF059 putative IMV protein VP55</fullName>
        </submittedName>
    </protein>
    <organism evidence="4">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957836.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q6TVR1"/>
    <dbReference type="GeneID" id="2947616"/>
    <dbReference type="KEGG" id="vg:2947616"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004900">
        <property type="entry name" value="Poxvirus_P35"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03213">
        <property type="entry name" value="Pox_P35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAR98284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="342" mass="37431" checksum="57A83C5F08962925" modified="2004-07-05" version="1">MDPPEITAYIIGVAEGRGTKEVFPTLPYLVGLADDPPKPQPAPAPSPAPAPAPAPAPAPSPAPAPAPKPSPPAPHPKGDHVLKAVEWKDVDSKDYPHFFTDMCKSTCPKEMQRRAAHHLNLWESISAGTVSTKYSDDDFILVVDNDMTFRKPEMVKPLIEAMKTNGWYMTQLKETYMTGALATNVPGTGDPELMVYPGGYDVSLDAYIINVGGMKKLYEAIIKEGGLRSGLLTEVFTLEKRLSLARVVLSGAEQVVYPEYYIQVKTRLGGAPSLWSLLATWLARFWPGAIYFLTTPLFSFMGLFDVDVVDVFILAYLLVLVLLLPNSRLLWFIAGLLVTAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVR2</accession>
    <name>Q6TVR2_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of a stable entry-fusion complex (EFC) which is at least composed of proteins A16, A21, A28, G3, G9, H2, J5, and L5. Formation of the viral membrane is necessary for the assembly of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Virion membrane</location>
            <topology evidence="2">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957835.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947615"/>
    <dbReference type="KEGG" id="vg:2947615"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039663">
        <property type="term" value="P:membrane fusion involved in viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005023">
        <property type="entry name" value="Pox_LP_H2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03356">
        <property type="entry name" value="Pox_LP_H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1168">Fusion of virus membrane with host membrane</keyword>
    <keyword evidence="5" id="KW-0426">Late protein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-1162">Viral penetration into host cytoplasm</keyword>
    <keyword evidence="3" id="KW-1160">Virus entry into host cell</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAR98283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="321" mass="35650" checksum="EFDBE5C464EC0DDB" modified="2004-07-05" version="1">MAAAPLRLTPATQCTSVGFFSASRRASSFTSAGMMEVMFVLSSSLSGMWYAVIPAGVEYLDMVMLTRHLKSTPESPRSTARASSALPKYTWSVSRVMPEGMASGGPARVHRNRSLAYHSLLSPIFIYMIQMADVTTLTANGLTLEFARERALRSLRAARTSTLVFFTLTLAASLFVLWLQLTEFPVFEELGKYARIKSAVRSWRPLVEAKTEIESDLGRQKTADRPELFEFRCVDFGKFYLPVRYSPTTFLPQAVRRGAGDGWMVHKAAAVDLAAQQFCESVLRHRANNVITCGSEMMRLVGYSGYFEDDHWCAATSGVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVR3</accession>
    <name>Q6TVR3_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TYR_PHOSPHATASE_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="15">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957834.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947614"/>
    <dbReference type="KEGG" id="vg:2947614"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039563">
        <property type="term" value="P:suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039502">
        <property type="term" value="P:suppression by virus of host type I interferon-mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="4" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1090">Inhibition of host innate immune response by virus</keyword>
    <keyword evidence="7" id="KW-1114">Inhibition of host interferon signaling pathway by virus</keyword>
    <keyword evidence="10" id="KW-1105">Inhibition of host STAT1 by virus</keyword>
    <keyword evidence="9" id="KW-0426">Late protein</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0899">Viral immunoevasion</keyword>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="13">
        <location>
            <begin position="88"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAR98282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="181" mass="20276" checksum="A17C1F7091A60591" modified="2004-07-05" version="1">MGDKSEWYARLLLRCTRAGPPLAMPSGMTRLTDHVYLGSAEDARAVLRGDSGVDFKCLVNMTMSKYSTPAGITAYHIPLRDDDKTNITSIMPALVKLLARLEAEKKPTLVHCVAGVNRSGAAAMGYVMHKRLAENPTMTQPARFVYFLKTYYEIRDLRGAFLENTNFRYQLIKMFVCDSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVR5</accession>
    <name>Q6TVR5_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF055 late membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957832.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947694"/>
    <dbReference type="KEGG" id="vg:2947694"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004251">
        <property type="entry name" value="Pox_virus_G9/A16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03003">
        <property type="entry name" value="Pox_G9-A16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="167" mass="18268" checksum="95E62542EDE8724A" modified="2004-07-05" version="1">MFFRRRAAPPTAPGPDAPDEEIYAFCDAHPDDERCACLKPSQAVVDTGRDTRLPYYCWYAPCKRADALLPRALKKNIAGCNVSDCVISLGDVRVADAVVRLTNACGSKVDSTAERFQAKYLNQHVFVPVADPRAWLPLCLVAAASLAVLPFVSRGPRTLSGRRPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVR8</accession>
    <name>Q6TVR8_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF052 putative IMV membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957829.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947691"/>
    <dbReference type="KEGG" id="vg:2947691"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005006">
        <property type="entry name" value="Poxvirus_J1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03338">
        <property type="entry name" value="Pox_J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="151" mass="16414" checksum="F7CA7249997B71BD" modified="2004-07-05" version="1">MDHEKYVLSMFLEEDNSFFSFVAALSDDEALGAVQSAAALLDFLLSVVVRGKEKLAAAGHHYDSIADGRARAAFEFRDLRELAQLFDRRPCGVQDRVRVRDGPARAFVDAALGLMRERGFDGAQAAERARYIAPNDLPALGAISATLSPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVS0</accession>
    <name>Q6TVS0_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Core protein VP8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">25 kDa major core protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">L4 core protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">P25K</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major core structural protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the chordopoxvirinae VP8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957827.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947610"/>
    <dbReference type="KEGG" id="vg:2947610"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019028">
        <property type="term" value="C:viral capsid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007586">
        <property type="entry name" value="VP8_pox_nuc-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04498">
        <property type="entry name" value="Pox_VP8_L4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0426">Late protein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAR98275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="259" mass="28569" checksum="BD8F0F7240979639" modified="2004-07-05" version="1">MTNLLSLVDQEDLAFCAGFPSFDETMLVIAGARVRFPRSLLSLFNVVPRTMTRYETELVGTEMVVGAVFTTAYNIRRNLGLGEDPVTMRDIEKYFLDSDNEVLTLIVHNTDFSAMSGVRRRGGRRITNPVIFRSGSTPLLIVMESRKKTNIYRERTAEQANASYREVGSSLALVTRYAGLQLVDVHTPSSVLTVSAVYGFTEDKGLKKLGSDKELADYQSTPLTDPIRLSDFSKLFDGVKKSIQLTNVPVPSAGAEAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVS1</accession>
    <name>Q6TVS1_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957826.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947609"/>
    <dbReference type="KEGG" id="vg:2947609"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005007">
        <property type="entry name" value="Poxvirus_L3/FP4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03339">
        <property type="entry name" value="Pox_L3_FP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="417" mass="45436" checksum="E559B6682548F9A7" modified="2004-07-05" version="1">MEEKRGRAKGGFARFGASRQAFRRGRGAPTGSTEPYVHRRVTFAPNAGRTRDGTSPAAQPAGDEADVRGDRNDRFEDASDEASKSNKSRERAPARRASRPTAAAARVERSSPPEPAPSRVPARITSPPAAHPSSGVGFLERRICDDVTAFTPVAMGMGEEEAGCWIELSTMVRCRKAVGFPVCRRSPHCPSTGMLTVCFESFGGWSCAQMRCADRPCAISDATAFQIVAILYHLYQRSIFLDDICLDVVSVPACTLTVSVSQLVFQMSTSSLVVLSPKTRLYRASLPQACYMDVVRLLMPAGSRFLCGGSGCAYFFEWIIRNHLDLLSKQFADMFRVQRRSVSGPPLHRRAEPGTLVLVSTNDAVVLGVTLTEVSVSDNVRVIWSADGSVFEIDDFPVQDVFAAPELVTRARAMVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVS2</accession>
    <name>Q6TVS2_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="10">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Early protein involved in early virion morphogenesis. Participates in the formation and elongation of crescent-shaped membrane precursors of immature virions in cytoplasmic factories.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chordopoxvirinae L2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957825.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947608"/>
    <dbReference type="KEGG" id="vg:2947608"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008447">
        <property type="entry name" value="Prot_L2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05803">
        <property type="entry name" value="Chordopox_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAR98273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="90" mass="10578" checksum="8D8C321658CE5333" modified="2004-07-05" version="1">MVRRVLLERVDGIVEHSRADRRYLEAIQRHLEGSTPGLRQMWRFIYDLLLTVFVVMYIVFRLIVRNPGICAILALAAAVYYLFLCLFSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVS3</accession>
    <name>Q6TVS3_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ORF047 putative myristylated IMV envelope protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with G4; this interaction involves formation of a transient disulfide-bonded intermediate, allowing disulfide bond transfer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Virion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957824.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947607"/>
    <dbReference type="KEGG" id="vg:2947607"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003472">
        <property type="entry name" value="Virion_mem_poxvirus_L1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02442">
        <property type="entry name" value="L1R_F9L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7" id="KW-0261">Viral envelope protein</keyword>
    <keyword evidence="4 7" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAR98272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="244" mass="26032" checksum="AE113C73F2696DA9" modified="2004-07-05" version="1">MGAAASIQTTVTTVSERIRNELEQSASASATADCDVTIGSLIIRKNLGCSVSVRNMCSANAGAQLDAVMKAVSSTFNDLSSDQKAYVPGLLTAALNIQTTVNTAVKDFETYVKQTCTADAVIHNKIKIQNIVMEECASLPGSPATHLEFVNTGTAAGNCGVKAVMDVLAKASTTVRNNQEAGKGYQTIIIAIVVAILAAIFAWYARHMLFMSTSDKIKLELAKKPVVHWTTYLDTFFTEFPPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVS4</accession>
    <name>Q6TVS4_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF046 putative myristylated protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957823.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947606"/>
    <dbReference type="KEGG" id="vg:2947606"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004251">
        <property type="entry name" value="Pox_virus_G9/A16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03003">
        <property type="entry name" value="Pox_G9-A16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="334" mass="36577" checksum="67F97F9374C14DEC" modified="2004-07-05" version="1">MGGSVSLPSRDLPPPVRTPEMNIVPERDLADTMARLSTADPPQPLGVGDDARMAVLKTTFPEFAISRPATGMLAAQRIRYDGDPRVCCGGFGISHYWEKGARRSNVAFEGAALHTCDPTRFDEGACDALLFRECAAGSVDADFCAHWINAAVTRRTNKQARDKLNNMFVSDCKNDASRPHCVAWIRAMRSTHKTADDTLIDNVLSVQSPEFKSKHMRCSYPSPATLAMAANVDEPRECWDPECVAGNVDFMLSDNYTNLGLCRLSRCSVGVTHLRMDARSRLRMRCAGALAGLTKAPVNQTVVVGDNLARAFEPRVETLGVLALCVVYLLIVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVS5</accession>
    <name>Q6TVS5_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Late transcription factor 1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with RNA polymerase to initiate transcription from late gene promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with the late transcription factors VLTF-2 and VLTF-3. Interacts with the late transcription elongation factor H5/VLTF-4. Interacts with itself.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chordopoxvirinae VLTF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957822.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947605"/>
    <dbReference type="KEGG" id="vg:2947605"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005022">
        <property type="entry name" value="Pox_TAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03355">
        <property type="entry name" value="Pox_TAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAR98270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="266" mass="30521" checksum="65CD232E7EAD0E13" modified="2004-07-05" version="1">MTLRIKLEKLKQIVTYFSEFSEEVSVNVDVGDGLMYIFAALGGSVNIWTIVPLSASVVYDGDVSRVFNLPVLKVKACLCSFHPDSVVSLEPDLEDNVVRLSSHHVVSVDCDNEPVAHRTNTAICLGINQRKSYVFNFRRYEEKCCGRTIVNLDLLLGFIKCIHQYQYITVCFRDKKMVLHTPGKVDNFFREYSMTEWAPDLERFSFKIPISSVNKLRGFKKRVVMFESRVVMDADDNIIGMLFTDRVGMYRVNVFMSFQDRSLSCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVS7</accession>
    <name>Q6TVS7_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957820.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947653"/>
    <dbReference type="KEGG" id="vg:2947653"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024453">
        <property type="entry name" value="Peptidase_C92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05708">
        <property type="entry name" value="Peptidase_C92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="185" mass="19824" checksum="F612C5809A5E8CA4" modified="2004-07-05" version="1">MREFGLAARMARAIEDVCPRGAVIFVSSAASMTDCLNPSVFKHAAIYAGRVDRALLLPPLPVPAEAVTEPCAIDAIAPYGARVVLLSELLRSCVAVQAYRLAVPGALALMNLAADAAFELVGTPYGFNSDRTYCFKLVADCFASVGVITKTRRIMGRDVVLSQDFLESGMWTKVLDSAAEPPWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVS9</accession>
    <name>Q6TVS9_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957818.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947651"/>
    <dbReference type="KEGG" id="vg:2947651"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007678">
        <property type="entry name" value="Poxvirus_G5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04599">
        <property type="entry name" value="Pox_G5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="452" mass="49218" checksum="F1D2B41169253923" modified="2004-07-05" version="1">MGIKNLKALLLSHGALTPHEPGGDERFPAVFVDGFSVMMTMAYSCADEDEFRAAVEERVQHWMSVSESGRIAVFIDRGEIPIKQPLRDQRRKATRDRAARHREFIAAAEADAAAEAVGAREDKQEDEHAEFAEEIRAEKQLRLQRIRFQLSIANHEVVKSLIESTLARAGDAVEIVFCDGVDAEMVMCVRGRAEAARCGRWPLLVTTDQDALLFTSTDRDEKIVSTVSACYAFRPTETTEYLCKLAALANGCDFFPGLGGICVSVESLRRATLFPEFSVRNAAVSLCTRPMRLSTQDALEPEAAAEVVEFIRRYASGDEGIYRAAPPSACCGRAFVRGALAAEWADALPAATGLGVVADMIACLPARRDPAPEEVERLLALEARARGARVTDAMLAQTAQLLGYGASAGADGTSAFAVSGTKGLMCRLRGTAMFFNAEYVEIESEPRLLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVT0</accession>
    <name>Q6TVT0_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutaredoxin-2</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Glutaredoxin necessary for virion morphogenesis and virus replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957817.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947650"/>
    <dbReference type="KEGG" id="vg:2947650"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008554">
        <property type="entry name" value="Glutaredoxin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05768">
        <property type="entry name" value="Glrx-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0249">Electron transport</keyword>
    <keyword evidence="1" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="137" mass="14963" checksum="30FFEB28C9BB8312" modified="2004-07-05" version="1">MASDASPTAAKLTLILLGKPLCSVCEVTRRMLARLEGEMELKCVNILSLFSKDGAVNVLGMGVYRLITEVTEHFGNEYVLLLKYDPVAKAMAAVDIRSFVVVAQIDEKKVDIDQLRDAILSAKPGVWPVGQPSSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVT3</accession>
    <name>Q6TVT3_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Metalloendopeptidase</fullName>
            <ecNumber evidence="4">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="6">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the peptidase M44 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="4"/>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957814.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947665"/>
    <dbReference type="KEGG" id="vg:2947665"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019058">
        <property type="term" value="P:viral life cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005072">
        <property type="entry name" value="Peptidase_M44"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03410">
        <property type="entry name" value="Peptidase_M44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015679">
        <property type="entry name" value="Peptidase_M44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAR98262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="603" mass="68096" checksum="35A1C47D303AA6BB" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVT4</accession>
    <name>Q6TVT4_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase NPH-II</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nucleoside triphosphatase II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Nucleoside triphosphate phosphohydrolase II</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">NTP-dependent helicase that catalyzes unidirectional unwinding of 3'tailed duplex RNAs and plays an important role during transcription of early mRNAs, presumably by preventing R-loop formation behind the elongating RNA polymerase. Might also play a role in the export of newly synthesized mRNA chains out of the core into the cytoplasm. Required for replication and propagation of viral particles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957813.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947664"/>
    <dbReference type="KEGG" id="vg:2947664"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021892">
        <property type="entry name" value="NPH-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12011">
        <property type="entry name" value="NPH-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="178"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="387"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAR98261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="683" mass="75974" checksum="14464EBAE47D71B5" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVT5</accession>
    <name>Q6TVT5_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ORF035 virion core protease</fullName>
        </submittedName>
    </protein>
    <organism evidence="8">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C57 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957812.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="MEROPS" id="C57.001"/>
    <dbReference type="GeneID" id="2947626"/>
    <dbReference type="KEGG" id="vg:2947626"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004970">
        <property type="entry name" value="Peptidase_C57"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03290">
        <property type="entry name" value="Peptidase_C57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAR98260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="430" mass="48708" checksum="1A7ABAFE1207F0CB" modified="2004-07-05" version="1">MDKYTDLVVSKIPELGFTNLLCHIYSVVGLSAHLDVSNFKTNCNGYVVRRFDESATAGRVSCIPLAALLDFAKRGLIDAAPPDTEKDEVAQKTALLASLKGRYGFREAIALEWKVPLGFFFKPSLREKVSEAVDFSQMPLNVDDLARAGVSTGVNTKVVPIAIKPDRGAWMSNVSIQSLVAPFAFGTEVAYLGQFNLNFLNGAAIHEKADRFRCNMISLTLKDKIERAGRRYVMFGFCYMFHWKCCIFDTVSRLVSFYDSGGNSPSEFHPCKYFYFYSFSDGFNVNAETADLDNRNCDVDVLMRFFVDNFKARRGCINLEVNQLMESECGMFTCIFMILCTIKHPDNFRTLRCIYTYFRFLADKKMTLLKSILFDPTAPKLEAVEVLSDGMKEYMKMERWTRKSVQVLSERITSRINSLLPPEPEKPAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVT6</accession>
    <name>Q6TVT6_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pox_I6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957811.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947625"/>
    <dbReference type="KEGG" id="vg:2947625"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016032">
        <property type="term" value="P:viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007674">
        <property type="entry name" value="Poxvirus_36kDa_major_membrane"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04595">
        <property type="entry name" value="Pox_I6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pox_I6" evidence="1">
        <location>
            <begin position="30"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="389" mass="41993" checksum="B32BFF56755A6996" modified="2004-07-05" version="1">MNHFFKQIGAGVRKPATRLTPSGAHEIRLFTVPVELPEFIYNNENLFQKPVNSVDTVLKALAVASAFREEWEAVRALARALQAAGVHVCDVFFSPVGWMAGTAPPPGAHAAVRVVAPSAASAARAVKQTVRALRPAAAMVPGEAREDAVVEVQEFSSAYAGHGPPPVGVMAVCPFDQDASVLVLFFGRTQDAHCGIAYRCATRTETDRMLATLLPIVSELHVVCDDVGRSTVTRHRGGGAATQFPDDRVTSIVGVVHPFDHRQFPSAPSASPSSDLVLYAPKRFVFVVDLPSGVDIRCASRSGTDFVTHINGRKLDAVLVIVKDAFMAGVTMDGVFQKENLVWRGKYTYRVTKSSFEVPEFRGKAGGHPPDGRVLASREFVTRSLYTVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVT7</accession>
    <name>Q6TVT7_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ORF033 putative IMV membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Virion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Chordopoxvirinae I5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957810.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947624"/>
    <dbReference type="KEGG" id="vg:2947624"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006803">
        <property type="entry name" value="Poxvirus_I5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04713">
        <property type="entry name" value="Pox_I5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0426">Late protein</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAR98258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="78" mass="8477" checksum="F8D7CB3D732CB3B5" modified="2004-07-05" version="1">MESRDLGVAVGATILMLLIVVTNGATIARRGAPSLGIRSRGALRVLTVLDFVSLLTTIPCTIILYFLYMQALNSRRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVT8</accession>
    <name>Q6TVT8_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein I3</fullName>
        </recommendedName>
    </protein>
    <organism evidence="4">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homoomultimer. Interacts with the small subunit of ribonucleotide reductase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Localizes in cytoplasmic virus factories, where it is associated with viral DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chordopoxvirinae I3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957809.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947623"/>
    <dbReference type="KEGG" id="vg:2947623"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030430">
        <property type="term" value="C:host cell cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006754">
        <property type="entry name" value="Poxvirus_I3_ssDNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04661">
        <property type="entry name" value="Pox_I3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003767">
        <property type="entry name" value="VAC_I3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-1035">Host cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAR98257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="285" mass="31308" checksum="C2E3281EF9489D06" modified="2004-07-05" version="1">MKRAVSKTTVASNRAPQQEDAAPARRFGENQAMSCTDAINFAKSLSSSQTKAIDAVTLTPSQYPSCSNINVCLVESLASKLVSPLIVVKGEFKIYPSKKTDMQRQNDNGYFGRLKPVSASPLLYQLLENIYENIKTGVRVPPSLRNFNTETSIDNTFKSGCLYLNRLTGALLEFTSDDDAQPQICPLIREIENLATRDAQMATLILAPVVFYRSGGEGKVTFAVKKITMPRECSLTVLGLEGEQTCVRMSETQPTFTEEQDVRGLGVVDPGTGFEDEELEAPFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVT9</accession>
    <name>Q6TVT9_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="12">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Late protein which probably plays a role in virus entry into the host cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Virion membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the chordopoxvirinae I2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957808.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947622"/>
    <dbReference type="KEGG" id="vg:2947622"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009175">
        <property type="entry name" value="Poxvirus_I2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12575">
        <property type="entry name" value="Pox_EPC_I2-L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003766">
        <property type="entry name" value="VAC_I2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0426">Late protein</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAR98256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="70" mass="7842" checksum="ADA2C8E44F06878A" modified="2004-07-05" version="1">MDKLYTGVFGSFLSNSDEDFEEFLNIVRTVMTEKPACDRPKGVPWTTVFLIGLIAAAIGVLLCFHYLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVU1</accession>
    <name>Q6TVU1_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957806.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947620"/>
    <dbReference type="KEGG" id="vg:2947620"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021155">
        <property type="entry name" value="Poxvirus_E2/O1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04497">
        <property type="entry name" value="Pox_E2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="806" mass="91158" checksum="D9A7101440A1D9C1" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVU2</accession>
    <name>Q6TVU2_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957805.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947619"/>
    <dbReference type="KEGG" id="vg:2947619"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021155">
        <property type="entry name" value="Poxvirus_E2/O1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006732">
        <property type="entry name" value="Poxvirus_O1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04497">
        <property type="entry name" value="Pox_E2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015980">
        <property type="entry name" value="VAC_O1L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAR98253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="709" mass="76873" checksum="CEAC30073C9CA569" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVU3</accession>
    <name>Q6TVU3_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ORF027 virion core protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="6">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chordopoxvirinae E11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957804.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947649"/>
    <dbReference type="KEGG" id="vg:2947649"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009201">
        <property type="entry name" value="Virion_core"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06138">
        <property type="entry name" value="Chordopox_E11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015797">
        <property type="entry name" value="Virion_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0426">Late protein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAR98252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="137" mass="15353" checksum="EEC96124E96C33CD" modified="2004-07-05" version="1">MEAINVFLETASGRTRILYSADTCECPTQCRATARRAAASVLEELDKYIVVSESTFTLAVRDYDIFYYLCDRGRLSLAENEFYLFNHGLLFTDDAGEEPVTGVGFVITDSMHVHVKPREGIAVTVYSDNSRAYEGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVU4</accession>
    <name>Q6TVU4_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="9">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR'</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957803.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947648"/>
    <dbReference type="KEGG" id="vg:2947648"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006890">
        <property type="entry name" value="Sulphydryl_Oase_FAD-link_ERV1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04805">
        <property type="entry name" value="Pox_E10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015696">
        <property type="entry name" value="VAC_E10R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="SSF69000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAR98251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="96" mass="11494" checksum="0E3D44CF33CE34A2" modified="2004-07-05" version="1">MEPRFWGRAMWAVIFIVLRRFEEHRDLERCKRQLYVICSTLPCIACRRHATAAIEKNNVLSSEDPNYVLFFFIKLFNNLAFDDRYKIDPAKVRPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVU5</accession>
    <name>Q6TVU5_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">DNA polymerase</fullName>
            <ecNumber evidence="2 12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="18">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with A20. Component of the Uracil-DNA glycosylase(UDG)-A20-polymerase complex; A20 and UDG form a heterodimeric processivity factor that associates with E9 to form the processive polymerase holoenzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2 12"/>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957802.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947647"/>
    <dbReference type="KEGG" id="vg:2947647"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039693">
        <property type="term" value="P:viral DNA genome replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013617">
        <property type="entry name" value="DNA-dir_DNA_pol_B_vir_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013660">
        <property type="entry name" value="DNApol_B_exo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08408">
        <property type="entry name" value="DNA_pol_B_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08452">
        <property type="entry name" value="DNAP_B_exo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-1194">Viral DNA replication</keyword>
    <feature type="domain" description="DNAP_B_exo_N" evidence="16">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="14">
        <location>
            <begin position="107"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B_3" evidence="15">
        <location>
            <begin position="355"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="13">
        <location>
            <begin position="494"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="AAR98250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="1012" mass="114428" checksum="5FD6F76790482E3C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVU6</accession>
    <name>Q6TVU6_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957801.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947646"/>
    <dbReference type="KEGG" id="vg:2947646"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="292" mass="32735" checksum="49D1C40CE7263811" modified="2004-07-05" version="1">MASYVSGASASANTAQGGNSQYPQYYSHTRTSQGDVRDESENRLHITDDEHLVLSDDCLGNGASYCGHSHNHAHNHSRRGGDRHRQRAPRLYEDPVPANIMVPTLSLEQLLEETSVAGGLLGGNAEKDVEQLLEEFSALCPGDQITALRCMAASFYRDALFAPYACMHLIASRMRVHYAREVVHVAEDLADAMSATSGVCFRRYRKRVLEDMLAEEMSVYTYLARANADICEDNLLSAVETLLRRFRRMGCYRSLCMLKILALQHEDLAGFIRRSIRKTCNFAHARTHTVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVU7</accession>
    <name>Q6TVU7_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF023 putative membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957800.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947635"/>
    <dbReference type="KEGG" id="vg:2947635"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005057">
        <property type="entry name" value="Poxvirus_E8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03394">
        <property type="entry name" value="Pox_E8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015690">
        <property type="entry name" value="VAC_E8R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="272" mass="31043" checksum="ACC515B828BA333D" modified="2004-07-05" version="1">MVDSGTHDVDSAAQERTPNQQTFFTKGLSPLMRHTYIYNNYAYGWIPETALWSSRLGDYRVTDFYPISLGMLKKFEFMFSLLADPGGACPAYEPKLNTEFLNRGSFSGRYVNPFHRFAALPEREYISFLLLSSVPIFNILFWFKGETFDTAKHSLLGAVYTTPERHIELARYLRRTGDYKPLFSRLGNDDTYSKPFSGFTRISNPTPIGRLPPSDFETLANLSTILYYTRYDPVLCFLVFYVPGLSATTKITPGVEFLMEKLSLAPENVVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVU9</accession>
    <name>Q6TVU9_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">DNA-directed RNA polymerase 30 kDa polypeptide</fullName>
            <ecNumber evidence="2 11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the poxviridae DNA-directed RNA polymerase 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="2 11"/>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957798.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947633"/>
    <dbReference type="KEGG" id="vg:2947633"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009162">
        <property type="entry name" value="RNA_pol_30_chordopoxvir-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024394">
        <property type="entry name" value="RNA_pol_30_chordopoxvir-type_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12410">
        <property type="entry name" value="rpo30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="TFIIS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000745">
        <property type="entry name" value="VAC_RPO30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="140"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAR98246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="193" mass="22012" checksum="D9322FE2F25813D9" modified="2004-07-05" version="1">MDEHRLRDLAAKHTDAAEAARIARWALDCAQRFALKNIVNTKTSNTDETNFEPAHNIGIEYSKDAKNRLSYKNKRSLEVDANEDYADLRAQIRATSGTEHDALRYLLFAVKCVAARVPYDIEEVPDHDYSGYFNVLDEKFNLPCPSCQSKNTMPMMIQTRSADEPPLIKYACKNCQKSFNPPKFCEKKGKQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVV0</accession>
    <name>Q6TVV0_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ORF020 dsRNA-binding PKR inhibitor</fullName>
        </submittedName>
    </protein>
    <organism evidence="5">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957797.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947632"/>
    <dbReference type="KEGG" id="vg:2947632"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003726">
        <property type="term" value="F:double-stranded RNA adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0039503">
        <property type="term" value="P:suppression by virus of host innate immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009179">
        <property type="entry name" value="E3L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042371">
        <property type="entry name" value="Z_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02295">
        <property type="entry name" value="z-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004008">
        <property type="entry name" value="VAC_E3L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00550">
        <property type="entry name" value="Zalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50139">
        <property type="entry name" value="Z_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Z-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="109"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAR98245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="183" mass="19925" checksum="5A7EFBB12D79E570" modified="2004-07-05" version="1">MACECASLILELLRKSDDKLPAKQIAKELGISKHEANRQLYRMLELDDVCCEDGNPPRWFVECAPSAPTEEDENSDTEPMETEAGCDTLFGGDIDIMTQSAVMRLKSLNPVSAVNEFCMMTHRSLEFCETRSGGKDHCPLFTCTITISGKVVAAADGASKKLARHTACASALTILINNCGISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVV1</accession>
    <name>Q6TVV1_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957796.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947671"/>
    <dbReference type="KEGG" id="vg:2947671"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007585">
        <property type="entry name" value="Poxvirus_E2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021155">
        <property type="entry name" value="Poxvirus_E2/O1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04497">
        <property type="entry name" value="Pox_E2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015692">
        <property type="entry name" value="VAC_E2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="725" mass="81010" checksum="D358F02D99F110A3" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-09-29" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVV3</accession>
    <name>Q6TVV3_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ORF017 DNA-binding phosphoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="8">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poxviridae F17 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957794.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947669"/>
    <dbReference type="KEGG" id="vg:2947669"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019082">
        <property type="term" value="P:viral protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006854">
        <property type="entry name" value="Phosphoprotein_F17"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04767">
        <property type="entry name" value="Pox_F17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003688">
        <property type="entry name" value="VAC_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAR98242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="105" mass="11641" checksum="B0F960B58DBD568A" modified="2004-07-05" version="1">MDGGVHKRPFIVNVEGMGRVLVLRYVRMCEVPEAKCEGSRASCVLKMDPPRSPGCERRPPLPPSPPCPVRTPPGSPLQAPLMRTQMLQGLFDTAKNNGEQMCRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-10-07" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVV4</accession>
    <name>Q6TVV4_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein F16</fullName>
        </recommendedName>
    </protein>
    <organism evidence="6">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Host nucleus</location>
            <location evidence="1">Host nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chordopoxvirinae F16 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957793.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947668"/>
    <dbReference type="KEGG" id="vg:2947668"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044196">
        <property type="term" value="C:host cell nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006798">
        <property type="entry name" value="Poxvirus_F16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04708">
        <property type="entry name" value="Pox_F16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AAR98241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="259" mass="28935" checksum="F5BCA62A0AC40778" modified="2004-07-05" version="1">MIRIGGRMEVEVDENATRAARGAMLLSTSFMESMVDIVRQEELARQFCYKNGMTPCVSVRMTGRIDASNIGEDTWDLARSHDVRHVVLFKASVVDWRVEELFVGISEKLGGLDALYFVADGFYVDASPTRFKPVDGMETMLRCVLRDVMEDVGGGVLHPREPSAASQCLMDRYMVPFGCLLAMQAHFARRPGRAPTPPARRASPRPGARRSPLHGYADSAMYIQALAAARRAGSQLRRRRARDDVLSLCRNLHSMRVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVV5</accession>
    <name>Q6TVV5_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957792.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947705"/>
    <dbReference type="KEGG" id="vg:2947705"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="539" mass="59668" checksum="A6BF5676A1210552" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVV6</accession>
    <name>Q6TVV6_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF014 modified RING finger protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957791.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947704"/>
    <dbReference type="KEGG" id="vg:2947704"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="93" mass="10176" checksum="CCBC770A94B1231A" modified="2004-07-05" version="1">MPIKVRQWRLAVSCTLACSDVCYICNKRSPEGCINAACPGACPFQVMVCGHGYHVHCLSPTNTEVCFVCRSALQKAELPDMSTSESASREFMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVV7</accession>
    <name>Q6TVV7_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957790.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947703"/>
    <dbReference type="KEGG" id="vg:2947703"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="79" mass="8668" checksum="25A604F433904315" modified="2004-07-05" version="1">MGVVMCGCLFVWAGWIARRVRGLCAALRRGVSRDKGYVAVIQTCDDDYFTEEEFNDGKQVVALLRDVSRVVAAPAGVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVV8</accession>
    <name>Q6TVV8_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957789.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947702"/>
    <dbReference type="KEGG" id="vg:2947702"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="89" mass="10252" checksum="E44C6D5F53B758F8" modified="2004-07-05" version="1">MLIYGPRLEVNDLIDRMMDDVQVNGDLMPSPDPIPEEVAQCSPEDMSIMLDQFLENIQLKSELQLLTSEEMDELLTELEELARLLKDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVV9</accession>
    <name>Q6TVV9_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF011 putative EEV envelope phospholipase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957788.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947733"/>
    <dbReference type="KEGG" id="vg:2947733"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032803">
        <property type="entry name" value="PLDc_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13918">
        <property type="entry name" value="PLDc_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="378" mass="41635" checksum="41516E11FA49EA89" modified="2004-07-05" version="1">MWPFSSIPVGADCRVVETLPAEVASLAQGNMSTLDCFTAIAESAKKFLYICSFCCNLSSTKEGVDVKDKLCTLAKEGVDVTLLVDVQSKDKDADELRAAGVNYYKVKVSTKEGVGNLLGSFWLSDTGNWYVGSASLTGGSVSTIKNLGLYSTNKHLAWDLMNRYNTFYSMIVEPKVPFTRLCCAVVTPTATNFHLNHSGGGVFFSDSPERFLGFYRTLDEDLVLHRIENAKNSIDLSLLSMVPVIKHAGAVEYWPRIIDALLRAAINRGVRVRVIITEWKNADPLSVSAARSLDDFGVGSVDMSVRKFVVPGRDDAANNTKLLIVDDTFAHLTVANLDGTHYRYHAFVSVNAEKGDIVKDLSAVFERDWRSEFCKPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVW0</accession>
    <name>Q6TVW0_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ORF010 putative EEV maturation protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="5">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Host endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the poxviridae F12 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957787.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947732"/>
    <dbReference type="KEGG" id="vg:2947732"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044174">
        <property type="term" value="C:host cell endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016032">
        <property type="term" value="P:viral process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005005">
        <property type="entry name" value="Poxvirus_F12L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03337">
        <property type="entry name" value="Pox_F12L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015793">
        <property type="entry name" value="VAC_EEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAR98235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="643" mass="69960" checksum="3F71B82F4EB63362" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVW3</accession>
    <name>Q6TVW3_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <ecNumber evidence="4">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <organism evidence="10">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="4"/>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957784.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947690"/>
    <dbReference type="KEGG" id="vg:2947690"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase" evidence="8">
        <location>
            <begin position="26"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAR98232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="169" mass="17919" checksum="9AF4BDF9C1B95A1B" modified="2004-07-05" version="1">MAARHTSLAMEFCCTETLRVVRLSQNATIPTRGSPGAAGLDLCSAYDCVVPSHCSCVVFTDLLIKLPPGCYGRIAPRSGLAVKHFIDVGAGVIDEDYRGNVGVVLFNFGNSDFEVKKGDRIAQLICERISHPAVQEVNRLDDTDRGDSGFGSTGSGACGGSGDTVWYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVW5</accession>
    <name>Q6TVW5_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957782.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947688"/>
    <dbReference type="KEGG" id="vg:2947688"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="115" mass="11564" checksum="4F6AFB6C160D7C91" modified="2004-07-05" version="1">MTPTSQESLLTTLLVEHLVRARRPSPVLVRALLAAGARAAGPDAAGRLPLAALLRAALRRGGPLDARLPLLLARRGAAASARDARGRSAAALLRAAGARGQRLAAALAAAGRAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVJ3</accession>
    <name>Q6TVJ3_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Viral interleukin-10 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="11">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functional viral cytokine homolog that plays a role in regulating host immune response.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the IL-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957904.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q6TVJ3"/>
    <dbReference type="GeneID" id="2947681"/>
    <dbReference type="KEGG" id="vg:2947681"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005125">
        <property type="term" value="F:cytokine activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006955">
        <property type="term" value="P:immune response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001817">
        <property type="term" value="P:regulation of cytokine production"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009079">
        <property type="entry name" value="4_helix_cytokine-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000098">
        <property type="entry name" value="IL-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020443">
        <property type="entry name" value="IL-10/19/20/22/24/26_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020423">
        <property type="entry name" value="IL-10_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00726">
        <property type="entry name" value="IL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01294">
        <property type="entry name" value="INTRLEUKIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00188">
        <property type="entry name" value="IL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47266">
        <property type="entry name" value="SSF47266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00520">
        <property type="entry name" value="INTERLEUKIN_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0202">Cytokine</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 9" id="KW-1125">Evasion of host immunity by viral interleukin-like protein</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0899">Viral immunoevasion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAR98352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="184" mass="21539" checksum="2DDCA7F9AF136525" modified="2004-07-05" version="1">MSNKKILVCVVIILTYTLYTDAYCVEYKESEEDRQQCSSSSFPASLPHMLRELRAAFGKVKTFFQMKDQLNSMLLTQSLLDDFKGYLGCQALSEMIQFYLEEVMPQAENHGPDIKEHVNSLGEKLKTLRLRLRRCHRFLPCENKSKAVEQVKRVFNMLQERGVYKAMSEFDIFINYIESYMTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVJ6</accession>
    <name>Q6TVJ6_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957901.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947678"/>
    <dbReference type="KEGG" id="vg:2947678"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="532" mass="57120" checksum="321639C00C613B57" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-06-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVK4</accession>
    <name>Q6TVK4_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957893.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947701"/>
    <dbReference type="KEGG" id="vg:2947701"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="206" mass="22233" checksum="8C8BB3EB0257744F" modified="2004-07-05" version="1">MSSSSNEPTPKPKPPAPMTQEEFNKEVEKRREQKKEKSRTVERESETVTVSADGTEKTRTYERESVKTTESEKNNNPSTNDNKDKVTDNQPKEDDKKLEETPKDSEKPTPTEKPANTSSGDNKKEGEEATLESQPTPAPTQPSNSEAPTQPPSSETPPTQPPSSTPSTQPPSSTPSTEPTPEPAPSTEPTTNANGTPAATTSETTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVK8</accession>
    <name>Q6TVK8_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF112 putative chemokine-binding protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957889.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947697"/>
    <dbReference type="KEGG" id="vg:2947697"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003184">
        <property type="entry name" value="Orthopox_35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036540">
        <property type="entry name" value="Pox_vCCI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02250">
        <property type="entry name" value="Orthopox_35kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49889">
        <property type="entry name" value="SSF49889"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="288" mass="31464" checksum="FC7BC839DB26C61E" modified="2004-07-05" version="1">MKVVLLLVLLGAFTNAAPLVGNQRLDSEEKANFCSTHQNEVYARFRLQMRVGVRHSPLYTPSNMCMMDIEDSIMDIENSTEKEYTSAATGDANGVNVSVALIGEGVSIPLSYIGLGFNPSLADGYLYVNVSSRAPWVQQTLDLSANGGWGINQILEKELLAIQIGCDNQKFPEEPTTTQPPSPVTTTLSSTTLDLTDENTDTTPLTTTSASVNRKRNPDDFDFSLLVDPRCVTSVDLHVELRDACIDYKEASQLSLKGKYGDGELVKKEIKDVGKDHNMCSLNLSPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVK9</accession>
    <name>Q6TVK9_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957888.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947696"/>
    <dbReference type="KEGG" id="vg:2947696"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009247">
        <property type="entry name" value="Chordopox_A35R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05989">
        <property type="entry name" value="Chordopox_A35R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="179" mass="20223" checksum="B51B4E49442442F1" modified="2004-07-05" version="1">MSRLQILTSFGQIYAPDEARLREIARDLGICTIKRAFGDMLYGFIDFNPVPLTQVNMLMSNCYFAVNGNLLPCTEDFRLRLPATEISAAYLTKTGRTILCGKDFNIIAPLGFKPSMRLRNLSHVSALVEILEFYSESGEYQFVLGPSAQFMLRLMEKENVCLFGSGWCIVDLRKLDVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVL0</accession>
    <name>Q6TVL0_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF110 EEV glycoprotein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957887.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947640"/>
    <dbReference type="KEGG" id="vg:2947640"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016186">
        <property type="entry name" value="C-type_lectin-like/link_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="167" mass="19006" checksum="069470700981FC39" modified="2004-07-05" version="1">MGCCRTPNRQCLLTLKRASCPVASLVSVLSVFTSICAIIKYTDLFLKEACENDWVPIKDLCVYNTQVITNVTLARDICASMDSDLPATPDTMFLKGIMFLVEATSFWMTHHDAYKNVYLPKRGSYLRSYVEEYNKDTHVCLINLQGLMHHDCNQNTTVVCVKKMYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVL2</accession>
    <name>Q6TVL2_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF108 DNA packaging protein/ATPase</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957885.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947638"/>
    <dbReference type="KEGG" id="vg:2947638"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006758">
        <property type="entry name" value="A32L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04665">
        <property type="entry name" value="Pox_A32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="274" mass="30894" checksum="80E00894DE2586DC" modified="2004-07-05" version="1">MDVVQEVRFKRESLIEAPFRMALVGGSGSGKTAYLLSLFRTLVRRFKHILLFTPVYNAAYDGFVWPDHIHKVTTHEELEYNLSVAKRKIERHAQTKKQKFLIILDDMGDTQTRSPTLLGLMNYGRHINVSLVLLCQTYKHIPVNGRASITHLCCCNVSDSDVENVLRSMSIRGSKKRLIRAMAIMRSAGTRRVLIIEDSVFCQNQERICYDFADESVVKRCLDPGILLAQFSHMKTRLADIVDAETKGDKGDRAGRGDGKDGSESDRGDADSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-02-10" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVL5</accession>
    <name>Q6TVL5_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="11">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Envelope protein required for virus entry into host cell and for cell-cell fusion (syncytium formation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poxviridae A28 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957882.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947686"/>
    <dbReference type="KEGG" id="vg:2947686"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019031">
        <property type="term" value="C:viral envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007664">
        <property type="entry name" value="Poxvirus_A28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04584">
        <property type="entry name" value="Pox_A28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0426">Late protein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0946">Virion</keyword>
    <keyword evidence="9" id="KW-1160">Virus entry into host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAR98330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="140" mass="15248" checksum="0124B34A9BE74634" modified="2004-07-05" version="1">MDAVSALCVALAAAAAMFVTLQLWAVYENYDNIREFNAANAALEFARTAGGPRVDRRVFDPNDEAFDVRKKWRCVLFKGAAVAASEFGFRSHDGVSPARFASVEACADEIFTAASDFRVFNPCLPPNQGSEACLFLKSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVM4</accession>
    <name>Q6TVM4_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the chordopoxvirinae A19 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957873.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947711"/>
    <dbReference type="KEGG" id="vg:2947711"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007769">
        <property type="entry name" value="Poxvirus_A19"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05077">
        <property type="entry name" value="DUF678"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAR98321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="90" mass="9179" checksum="C6358EA4E8CFD2D9" modified="2004-07-05" version="1">MSAVKAKAGAKGGSKGGVVDVAAGNKKRRRRRVTTVVEDGDPVCSSCNSRLVSIKDVDRLSTLSLGLACSSTLSCAACGSALTPLRDLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVM7</accession>
    <name>Q6TVM7_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF093 predicted myristylated protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957870.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947643"/>
    <dbReference type="KEGG" id="vg:2947643"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004251">
        <property type="entry name" value="Pox_virus_G9/A16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03003">
        <property type="entry name" value="Pox_G9-A16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="358" mass="38982" checksum="6AB1823AC70C5D2E" modified="2004-07-05" version="1">MGDTVSKVEVLDTPTPGEYALRVTHTSATDTFAFAEETETFSDPKLKTVRPRFCLLPTMDPGQCGRFLSPELASRARLVRGPPCDSLFFRPGSLLRADYVPEIAKPYLRQGTMCVFEIGASAPPTDAAMARCCTNPGPGCPSVFANGYKTAHCDGVMASRCAVEPDAPECMAWLRTGRYAALDTYAALCAKHMDARFCSEFVRVARPASFAFGDSALRRYCDAHRAAPECACVAGTTLGKYLGPRVCRAHECTDQSRDRKWLFFSQDEQRSRCRYVGCRIDVDSLVMQNSRAHMIADCGKAVGAGYADPDPGVRDNASANLPAVPPFLVAALAAGVIFYFVAVYSRRSVETKTINVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVM8</accession>
    <name>Q6TVM8_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957869.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947642"/>
    <dbReference type="KEGG" id="vg:2947642"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="89" mass="9305" checksum="A3636316DE8F10A2" modified="2004-07-05" version="1">MFLDSDTVVVAVPGTSFPEGLFDRQGRPLRPGSTPTMSYEDPVPRTARALLLVNPTAGQLAAVAAGAPAGVRVLVLVDVARQDMPFSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVN3</accession>
    <name>Q6TVN3_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="9">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for viral crescent formation early during virus morphogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the poxviridae A11 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957864.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947707"/>
    <dbReference type="KEGG" id="vg:2947707"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007755">
        <property type="entry name" value="Poxvirus_A11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05061">
        <property type="entry name" value="Pox_A11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0426">Late protein</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAR98312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="336" mass="37328" checksum="4D2652507B615907" modified="2004-07-05" version="1">MTAVPVTDIPGDYGPTSFSEDNYPLNKHYELTKGQLSILRTVNDKLLARTVQHSDGESDESESEEDDISSPLPPDEEEPDSCVARVMPRDADLAAPKKADGYIIAAEQQRQQRINILVSDREAVVEREPVQTSFARVSAIPIHGDGARRTTASFSATTPSLGAVFDDAKRVRLLEEEVKELRKKCATSQDNGNLENFTKVLFGKAPRASELNKRVVIVNYATLNNVTLSMEDLEKCSDEEVDRMYSVIRRYNETRKKKILVTNVVIIGITVLEHVLVKLGFSEVRGLSADLSSELIDVEIGEDCEHIAERLGFGNSPVLNVALFVVKLFVRKLNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVN6</accession>
    <name>Q6TVN6_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Intermediate transcription factor 3 small subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">VITF-3 32 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">VITF-3 small subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="11">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts with RNA polymerase to initiate transcription from intermediate gene promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a 45 kDa (A23R) and a 32 kDa (A8R) subunit to form the virus intermediate transcription factor (VITF)-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chordopoxvirinae A8 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957861.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947723"/>
    <dbReference type="KEGG" id="vg:2947723"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006834">
        <property type="entry name" value="Pox_A8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04745">
        <property type="entry name" value="Pox_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="AAR98309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="303" mass="34333" checksum="2F332D1523498BB3" modified="2004-07-05" version="1">MFQPVPDMAAEADIDLGDVSVDATRAGAREKTVFFARNKRMYPHRSKDEERKLSLGFFLQRLDFLTSREVNLQFRSLDALRTENVMKKNNVLVAPYILIATLAGRGFRMTETMVELYFPELYRETSKRFRFCAQIKVIQDFLGFAHDSYHTYDFETYFAFVALVLRGADSVAEAFDVRAESGLVRSLTEITYRLYVMQLRSDAAQWSVSTGAVVSQAVNTVLSVVGDLAARAEAERLTPVCDLARENPLSLDDLRKYGPRLRSLLTTMARARSFKTNRRDKDTLSRFCRLTAGPSPSACRASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVP0</accession>
    <name>Q6TVP0_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF080 virion core protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957857.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947728"/>
    <dbReference type="KEGG" id="vg:2947728"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="328" mass="33846" checksum="92ACD8263CD02A2A" modified="2004-07-05" version="1">MDLRRRFASDLAKTKLVLSETSSSLFTKCPQAVIPTPEQPCPPDEEVDSVDKYTVKEAGRYYQSRLKSTTACMQRPTGQSPLAPSPLPRGARIQSVPLNVMPAACSTPVAACSATAVVCPPAAPACPAPAPACPAPVPACPAPAPACPAPAPACPAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPLPTKPAPAAKPIFLQQSLPPPQYPASSCPTIKAPAASPVLEPRVPDKIIDADNDDKDLIKKELADIADSVRDLNAESLSLTRDIETAKSVTQSAIDDLRRLLGSVATRETPSTLRDRVDNTGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVP4</accession>
    <name>Q6TVP4_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Viral late gene transcription factor 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Trans-activator protein A1</fullName>
        </alternativeName>
    </protein>
    <organism evidence="8">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts with RNA polymerase to initiate transcription from late gene promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with itself. Interacts with the late transcription factors VLTF-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chordopoxvirinae VLTF-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957853.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947676"/>
    <dbReference type="KEGG" id="vg:2947676"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004975">
        <property type="entry name" value="Poxvirus_VLTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010507">
        <property type="entry name" value="Znf_MYM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03295">
        <property type="entry name" value="Pox_TAA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06467">
        <property type="entry name" value="zf-FCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MYM-type" evidence="6">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AAR98301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="150" mass="16553" checksum="A6B3C4D49ED106B0" modified="2004-07-05" version="1">MKRIALSRVDISAPRASACAPPAACRIEYVLPKYFNTVSAERLALRAADGTCWFCRQRVSTAALAVETLDGGAVGEFCSRLCRDSFAGSIRHLVALREEPKIELLPLEMYADPDRVRALINETRATEGVYGRCYLEADGRTVRMALKSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVQ2</accession>
    <name>Q6TVQ2_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Primase D5</fullName>
        </recommendedName>
    </protein>
    <organism evidence="10">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Primase which may have roles in initiation of DNA replication or lagging-strand synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with A20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poxviridae D5 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957845.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947630"/>
    <dbReference type="KEGG" id="vg:2947630"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004968">
        <property type="entry name" value="DNA_primase/NTPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014015">
        <property type="entry name" value="Helicase_SF3_DNA-vir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014818">
        <property type="entry name" value="Phage/plasmid_primase_P4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08706">
        <property type="entry name" value="D5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03288">
        <property type="entry name" value="Pox_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51206">
        <property type="entry name" value="SF3_HELICASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SF3 helicase" evidence="8">
        <location>
            <begin position="479"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="AAR98293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="787" mass="88683" checksum="D60300399E665579" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="33" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVQ4</accession>
    <name>Q6TVQ4_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF066 virion protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957843.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947628"/>
    <dbReference type="KEGG" id="vg:2947628"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="291" mass="30355" checksum="86D433FDBFC5C180" modified="2004-07-05" version="1">MRERWPNTALTARSAERLSSRSARSKRCTRAGAPRWSRSTSTCRHASAAPTRSRLGASATRLFSACKSSRMADGSIYYCGGTHVVAAAPGAALVLLDALGAVAAAAPAGQRVFFAEYGLEKRAGGPITARLRRSGFRGAANAWASVADFEAGGRPSAWTLRAEEASRVPLPTDAALVLAWGARDEPLRACVLARAADAEAPVGAALKEAAFDARAPAAALFAALGAPALAPPLRARLVAPPGAPPRTRLCENPAMLRAFAVGWFGAQLGEASENEKVFAAFDKARSCLDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVR0</accession>
    <name>Q6TVR0_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase-associated transcription-specificity factor RAP94</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Protein H4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">RPO-associated protein of 94 kDa</fullName>
        </alternativeName>
    </protein>
    <organism evidence="12">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">DNA-directed RNA polymerase-associated factor required for the transcription of viral early genes as well as for transcription termination. Within minutes after virus entry, recruits the core RNA polymerase, the early transcription factor (ETF) and other enzymes needed for transcription initiation, elongation, and termination thereby allowing synthesis of early mRNAs which are extruded through pores in the core particle. Recruits the multifunctional J3 protein, with poly(A) polymerase-stimulatory, cap nucleoside-2'-O-methyltransferase, and transcription elongation activities. Interacts with NPH-I, a DNA-dependent ATPase required for the termination of early transcripts. Acts as a transcription termination factor by binding, together with the capping enzyme/VTF, to the termination motif 5'-UUUUUNU-3' in the nascent mRNA. Involved as well in the packaging of RNA polymerase and other components needed for early transcription in assembling virus particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Part of the early transcription complex composed of ETF, RAP94, and the DNA-directed RNA polymerase. Interacts (via N-terminus) with NPH-I. Interacts with J3. Interacts with ETF heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the poxviridae protein RAP94 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957837.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947617"/>
    <dbReference type="KEGG" id="vg:2947617"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004974">
        <property type="entry name" value="Pox_Rap94"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03294">
        <property type="entry name" value="Pox_Rap94"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="5" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="AAR98285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="804" mass="92131" checksum="319AC8083152D836" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVR7</accession>
    <name>Q6TVR7_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase</fullName>
            <ecNumber evidence="3 9">2.1.1.57</ecNumber>
        </recommendedName>
    </protein>
    <organism evidence="15">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the mRNAs 5' end, methylates the ribose 2' OH group of the first transcribed nucleotide, thereby producing a 2'-O-methylpurine cap. At the 3' end, functions as a processivity factor which stimulates the activity of the viral poly(A) polymerase VP55 that creates mRNA's poly(A) tail. In the presence of VP39, VP55 does not dissociate from the RNA allowing tail elongation to around 250 adenylates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside) in mRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67020"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="Rhea" id="RHEA-COMP:17168"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167609"/>
            <dbReference type="EC" id="2.1.1.57"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Methyltransferase activity: Monomer, poly(A) polymerase activity: Heterodimer composed of a catalytic component, VP55, and a processivity factor, VP39. Interacts with Rap94 and NPH-I; these interactions might help linking transcription to capping and polyadenylation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.57" evidence="3 9"/>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957830.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q6TVR7"/>
    <dbReference type="GeneID" id="2947692"/>
    <dbReference type="KEGG" id="vg:2947692"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:mRNA (nucleoside-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20756">
        <property type="entry name" value="capping_2-OMTase_Poxviridae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000176">
        <property type="entry name" value="mRNA_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025804">
        <property type="entry name" value="Pox/kineto_cap_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030375">
        <property type="entry name" value="Poxvir_cap_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01358">
        <property type="entry name" value="PARP_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003726">
        <property type="entry name" value="PolA_polym_reg_poxV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51612">
        <property type="entry name" value="SAM_MT_2O_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="306"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="active site" description="For methyltransferase activity" evidence="10">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="178"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="206"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>mRNA</name>
            <dbReference type="ChEBI" id="CHEBI:33699"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR003726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR003726-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR003726-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="AAR98278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="336" mass="38611" checksum="154576229983419A" modified="2004-07-05" version="1">MEGVEMDKPLLYFDEIAGAREYDAAFAEKHEPPKIPGRGQMKLLVCELVFLNRLHLHGMLDGSVIVYVGSAPGRHICCLHSHFQELGVSLKWVLIDGRKHDPCLSGLRNVTTVTRFADEAYLRELRGELRRSKIVLISDIRSNRVDTEPTTADLLRDYALQNTMVSVLKPVASSLKWRCPFPDSWEKDFYVPCGKEMLQPFAPPFSAEMRLLTVYSETRPKLRLITLSDAVNYEKRMFYLNSVVRQRVILNFDYPNQEYDFFHMFCLLSSVVCSCEFKSPKEKVLSLQNRFFRFLRIPPSITLGLRQHDEPPQHAVPGQDPLPKGRGKKRPLRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVR9</accession>
    <name>Q6TVR9_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF051 putative membrane protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957828.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947611"/>
    <dbReference type="KEGG" id="vg:2947611"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006956">
        <property type="entry name" value="Poxvirus_L5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04872">
        <property type="entry name" value="Pox_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="128" mass="13736" checksum="BD1B7F048D36BA99" modified="2004-07-05" version="1">MAAPTTPVVHLTPVFVEPTIAHSLLRAESYLAIAVLELVLALALALVFFRDELGALFRRAPRAPSPLDAYLQASLVCDGDALLIELPEGRVPALALDGRPVAFPGCESLLYRINGPRKVRLVDVLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVS6</accession>
    <name>Q6TVS6_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Assembly protein G7</fullName>
        </recommendedName>
    </protein>
    <organism evidence="9">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Late protein which is a part of a large complex required for early virion morphogenesis. This complex participates in the formation of virosomes and the incorporation of virosomal contents into nascent immature virions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Part of a complex composed of A30, G7, F10 kinase, A15, D2, D3, and J1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chordopoxvirinae G7 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957821.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947604"/>
    <dbReference type="KEGG" id="vg:2947604"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008787">
        <property type="entry name" value="Poxvirus_G7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05503">
        <property type="entry name" value="Pox_G7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="AAR98269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="398" mass="42821" checksum="A01C8F211992C01B" modified="2004-07-05" version="1">MESSKQAPRAGARVFESLLKFVVRGAACGCLSSTVDIEAKARLLPGSSPQRRAQIANAIHDLCIANVRVTTREDLVEALARLRRRFVHAGNSADLARLHGALMRFTHSTSFFAVCTPTVRVTLATLVASVLVGELMQAVDMAEAVERVIYTKNRPMASELADLLELKYGLVNMAQYKLMPALMEEAGCCDELVRAGAPDACTDSVAEMEAERLLDMPVRSSALSRLCDFMVRRGASPVHAASEFAAGLKIEEMPADADSAAAAPVPAPAAADFGSVVARTEDLLERARKESRGEVLDGAVSSPLGVAGSSPFDGITLEKFVLLEYLHVMKMLANCIEQRSCKERIRVSVNTQPFRTTSATPTPVDPAETADAEAQCRALQQRLQVARPVLGTRAPPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVT1</accession>
    <name>Q6TVT1_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ORF038 late transcription elongation factor</fullName>
        </submittedName>
    </protein>
    <organism evidence="2">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957816.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947667"/>
    <dbReference type="KEGG" id="vg:2947667"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008446">
        <property type="entry name" value="Chordopox_G2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05796">
        <property type="entry name" value="Chordopox_G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AAR98264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="231" mass="25112" checksum="E92F856BB2D747AA" modified="2004-07-05" version="1">MTFRELILFHAATHVVTGDPEAPRRAASLCHGFGVDFRAIHAEFARRYPRTAAAVERAQPLPEVDAAFPPDARRQVVRLRLEAAALVVKESRALSASMRGVAVVDGCCVRVCRANDELLEFLARRYDPAVYRYAEVPSPSVRPGSKVFACAGRSVTFAAAHQSRITANRPLRVVVTEACVDGVLARGAAEVFDRGSGVLPRALREIFYRLDEDGCPTGQTPGFADSMASRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVT2</accession>
    <name>Q6TVT2_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="14">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of a stable entry-fusion complex (EFC) which is at least composed of proteins A16, A21, A28, G3, G9, H2, J5, and L5. Formation of the viral membrane is necessary for the assembly of the complex. Interacts with L5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Virion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the chordopoxvirinae G3 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957815.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947666"/>
    <dbReference type="KEGG" id="vg:2947666"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055036">
        <property type="term" value="C:virion membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019064">
        <property type="term" value="P:fusion of virus membrane with host plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046718">
        <property type="term" value="P:viral entry into host cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010367">
        <property type="entry name" value="Poxvirus_G3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06129">
        <property type="entry name" value="Chordopox_G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1169">Fusion of virus membrane with host cell membrane</keyword>
    <keyword evidence="4" id="KW-1168">Fusion of virus membrane with host membrane</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-1162">Viral penetration into host cytoplasm</keyword>
    <keyword evidence="8" id="KW-0946">Virion</keyword>
    <keyword evidence="4" id="KW-1160">Virus entry into host cell</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="AAR98263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="110" mass="12259" checksum="6BC6959E4A2D27B6" modified="2004-07-05" version="1">MSWAVEFVLFAAFLAAAYVFTFLPTNKMQLAVRELADARAWRQRTDAQLDGISETVLFPRPDAPQGSAVIASIDARRARVTVAHGREKSTFDLKRRGDVQTLLPILLLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVU0</accession>
    <name>Q6TVU0_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere-binding protein I1</fullName>
        </recommendedName>
    </protein>
    <organism evidence="5">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 3">Late DNA-binding protein which binds to the hairpin form of the viral telomeric sequence. Required for the production of mature virions (MV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the chordopoxvirinae I1 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957807.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947621"/>
    <dbReference type="KEGG" id="vg:2947621"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004969">
        <property type="entry name" value="Poxvirus_I1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03289">
        <property type="entry name" value="Pox_I1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015625">
        <property type="entry name" value="VAC_I1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR015625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AAR98255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="321" mass="35956" checksum="8DC52C21A58EF0D6" modified="2004-07-05" version="1">MEDERLIFNKVNANVLKAYLCSRISDIVDEMVDRRHLQKKKSVARRVEMRIPVDLLHAPFVQEFALGAYRDGVLASLVSSIVENNFFSPDDGKLVDGAERVLILTPLETRILGCVPRESSLYIDVSDVKALANRLKSPPAHIECGGTRYDIDARHVDDFINVVANDGLLVLDEKSSIKDSMYVVDEELLCAMRRRFMRSPQISQGLISRSRLHDYLMRSMTREEQKIFVALKDAESADVLGLETVCLGDFVYAKHTALVSALSASLDRCSKRMHEDMYARLAHLVPDNTRMNVSKLVESLTVQSTRMELGSGLSPPPCGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-08-03" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVU8</accession>
    <name>Q6TVU8_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein E6 homolog</fullName>
        </recommendedName>
    </protein>
    <organism evidence="7">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Virion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the chordopoxvirinae E6 family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957799.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947634"/>
    <dbReference type="KEGG" id="vg:2947634"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019068">
        <property type="term" value="P:virion assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006749">
        <property type="entry name" value="Pox_E6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04656">
        <property type="entry name" value="Pox_E6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015629">
        <property type="entry name" value="VAC_E6R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0426">Late protein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0946">Virion</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="AAR98247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="567" mass="64888" checksum="07EB37D656D0B834" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVV2</accession>
    <name>Q6TVV2_ORFSA</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12 14">Poly(A) polymerase catalytic subunit</fullName>
            <ecNumber evidence="4 12 14">2.7.7.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Poly(A) polymerase large subunit</fullName>
        </alternativeName>
    </protein>
    <organism evidence="19">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12 14">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12 14">
            <text>ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 12 14">Heterodimer of a large (catalytic) subunit and a small (regulatory) subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 14">Belongs to the poxviridae poly(A) polymerase catalytic subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4 12 14"/>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957795.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947670"/>
    <dbReference type="KEGG" id="vg:2947670"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004652">
        <property type="term" value="F:polynucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037265">
        <property type="entry name" value="PolyA_pol_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024231">
        <property type="entry name" value="Pox_polyA_pol_nucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038419">
        <property type="entry name" value="Pox_polyA_pol_nucTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004976">
        <property type="entry name" value="Poxviridae_polyA_pol_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024397">
        <property type="entry name" value="Poxvirus_polyA_pol_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024398">
        <property type="entry name" value="Poxvirus_polyA_pol_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038337">
        <property type="entry name" value="Poxvirus_polyA_pol_cat_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03296">
        <property type="entry name" value="Pox_polyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12629">
        <property type="entry name" value="Pox_polyA_pol_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12630">
        <property type="entry name" value="Pox_polyA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015693">
        <property type="entry name" value="VAC-48L_nuct"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160957">
        <property type="entry name" value="SSF160957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12 14" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pox_polyA_pol_N" evidence="17">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pox_polyA_pol" evidence="15">
        <location>
            <begin position="120"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Pox_polyA_pol_C" evidence="16">
        <location>
            <begin position="271"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR015693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR015693-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="AAR98243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="472" mass="52921" checksum="541EC3207BD7C678" modified="2004-07-05" version="1">MAPPVIEEYLGSRPSMERCVLLRAQRRNMSRVLNFDRKLFLSLVVKSRRRFFKKLGGSEKEIAARIEEYFSRQRRLEKLGQILTVLELQSVIVGEFTRTLGSLTTPTPAINAAVRRVDATRARALASRALDSYAVLPPPEEAAPMARHKHSDLVEVVKRLVKEHLRRHNKRCVCYGSYALHLLNPEIEYGDIDMVQTNARPFLINLAFLIYFVTGRQTVLLRVPYLKNYVVLQDEEGGHILDSFNVRQATLRALPTLLVDNIYVLHPFVQLMAMLKMFSQTDRVRDLASNFDKARARMETLLAFALEELGEAPADGRTPLPCAFLPPEGGASRVLEADARALDCGFARAVVFLDEPALVQTLLDMGVQDDEIVDFESVSNSAFLVRDNTLFTYFSNTVLMDGDAVHDLSRRGVSAHIVMFLLLTRHPAAEGAVRSMLGSLVSDARPVTGVVERERKTGTHGVIDIAKNVITH</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="36" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVW1</accession>
    <name>Q6TVW1_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="4">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poxviridae F11 protein family.</text>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957786.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947731"/>
    <dbReference type="KEGG" id="vg:2947731"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007027">
        <property type="entry name" value="Poxvirus_F11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04943">
        <property type="entry name" value="Pox_F11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AAR98234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="452" mass="50314" checksum="5C649269AA888180" modified="2004-07-05" version="1">MFFWLWCGRPRMSALARLFGRFGRGRNQCVPTAGCMPLRRPRDGADGGDSDDDYEYGDTDSVASSVAPVEARPLVLTVPGTNCPVLVDSVFETRIENTSSVVTHVGDWSSISLFESTFHRAPARICRSEFSRYVRDANMHFEVGESYGLKLKHDEWYMRHHMAPTVAAYVAILCVKNEGMAGISVNNTKFLKTNMQEGDVLVVPAARSMFFLPQVGGDAEYIIVTLVPTAELRDLGFEVFPPSIDQEAQVLVANVAETRRKACKIVNRIVKLRVDLEKCYYEICKLVIMITEFNERYNDVGAQMITASVDAIARGMGGAAQTALCRQSLRGRRPLSAALTRNHSILEHGITGLFAVFAQTPEGTPHPDSLMARMERDLRELYSRFSELWDDILQLASDLDSTLPRCECIERYIHHMVCVSEAGVKRNELVQRLTMIAGAGYRLTGSGEGVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVW2</accession>
    <name>Q6TVW2_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ORF008 ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <comment type="interaction">
        <interactant intactId="EBI-15718527">
            <id>Q6TVW2</id>
        </interactant>
        <interactant intactId="EBI-359390">
            <id>Q13616</id>
            <label>CUL1</label>
        </interactant>
        <organismsDiffer>true</organismsDiffer>
        <experiments>5</experiments>
    </comment>
    <comment type="interaction">
        <interactant intactId="EBI-15718527">
            <id>Q6TVW2</id>
        </interactant>
        <interactant intactId="EBI-307497">
            <id>P63208-1</id>
            <label>SKP1</label>
        </interactant>
        <organismsDiffer>true</organismsDiffer>
        <experiments>5</experiments>
    </comment>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957785.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="DIP" id="DIP-48542N"/>
    <dbReference type="IntAct" id="Q6TVW2">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="2947730"/>
    <dbReference type="KEGG" id="vg:2947730"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="59"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="530" mass="57443" checksum="C2E50A0018D1A60C" modified="2004-07-05" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2004-07-05" modified="2020-08-12" version="34" xmlns="http://uniprot.org/uniprot">
    <accession>Q6TVW4</accession>
    <name>Q6TVW4_ORFSA</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <organism evidence="3">
        <name type="scientific">Orf virus (strain Goat/Texas/SA00/2000)</name>
        <name type="common">OV-SA00</name>
        <name type="synonym">Orf virus-San Angelo 2000</name>
        <dbReference type="NCBI Taxonomy" id="647330"/>
        <lineage>
            <taxon>Viruses</taxon>
            <taxon>Varidnaviria</taxon>
            <taxon>Bamfordvirae</taxon>
            <taxon>Nucleocytoviricota</taxon>
            <taxon>Pokkesviricetes</taxon>
            <taxon>Chitovirales</taxon>
            <taxon>Poxviridae</taxon>
            <taxon>Chordopoxvirinae</taxon>
            <taxon>Parapoxvirus</taxon>
        </lineage>
    </organism>
    <organismHost>
        <name type="scientific">Homo sapiens</name>
        <name type="common">Human</name>
        <dbReference type="NCBI Taxonomy" id="9606"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Capra hircus</name>
        <name type="common">Goat</name>
        <dbReference type="NCBI Taxonomy" id="9925"/>
    </organismHost>
    <organismHost>
        <name type="scientific">Ovis aries</name>
        <name type="common">Sheep</name>
        <dbReference type="NCBI Taxonomy" id="9940"/>
    </organismHost>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="J. Virol." volume="78" first="168" last="177">
            <title>Genomes of the parapoxviruses ORF virus and bovine papular stomatitis virus.</title>
            <authorList>
                <person name="Delhon G."/>
                <person name="Tulman E.R."/>
                <person name="Afonso C.L."/>
                <person name="Lu Z."/>
                <person name="de la Concha-Bermejillo A."/>
                <person name="Lehmkuhl H.D."/>
                <person name="Piccone M.E."/>
                <person name="Kutish G.F."/>
                <person name="Rock D.L."/>
            </authorList>
            <dbReference type="PubMed" id="14671098"/>
            <dbReference type="DOI" id="10.1128/JVI.78.1.168-177.2004"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Goat/Texas/SA00/2000</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="AY386264">
        <property type="protein sequence ID" value="AAR98231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="NP_957783.1">
        <property type="nucleotide sequence ID" value="NC_005336.1"/>
    </dbReference>
    <dbReference type="GeneID" id="2947689"/>
    <dbReference type="KEGG" id="vg:2947689"/>
    <dbReference type="Proteomes" id="UP000000870">
        <property type="component" value="Genome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009748">
        <property type="entry name" value="Orthopox_C10L"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07020">
        <property type="entry name" value="Orthopox_C10L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AAR98231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000000870"/>
        </source>
    </evidence>
    <sequence length="79" mass="7614" checksum="FC6A8623CD93DF80" modified="2004-07-05" version="1">MPGEGQYHIYSHSGTSKGFASTPGGAVKRPSSGSGIWGPLEKRMCVGGGSGGFWGGSKSLSGGVNGGVNGGVNGGCGKI</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>